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Conserved domains on  [gi|111309363|gb|AAI20960|]
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Keratin associated protein 10-1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 73-247 3.27e-09

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 54.80  E-value: 3.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111309363   73 SSCTPSCCQQSSCQPACCTSSPCQQACCMPVCCKPVCCLPTCSkdsssccqqsscqptccassssqqSCCVPVCCKPVCY 152
Cdd:pfam01500  18 GTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQ------------------------PCCQTSCCQPTCC 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111309363  153 VPTCSESSSSCCQQSSCHPACCTSspCQQACCVPVRCKPVCCKPICCVPvcsgastSCCQQSSCQPACCTTSCCRPSSSV 232
Cdd:pfam01500  74 QTSSCQTGCGGIGYGQEGSSGAVS--SRTRWCRPDCRVEGTCLPPCCVV-------SCTPPTCCQLHHAQASCCRPSYCG 144

                         170
                  ....*....|....*
gi 111309363  233 SLLCRPVCQPACCMP 247
Cdd:pfam01500 145 QSCCRPACCCQCSEP 159
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 73-247 3.27e-09

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 54.80  E-value: 3.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111309363   73 SSCTPSCCQQSSCQPACCTSSPCQQACCMPVCCKPVCCLPTCSkdsssccqqsscqptccassssqqSCCVPVCCKPVCY 152
Cdd:pfam01500  18 GTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQ------------------------PCCQTSCCQPTCC 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111309363  153 VPTCSESSSSCCQQSSCHPACCTSspCQQACCVPVRCKPVCCKPICCVPvcsgastSCCQQSSCQPACCTTSCCRPSSSV 232
Cdd:pfam01500  74 QTSSCQTGCGGIGYGQEGSSGAVS--SRTRWCRPDCRVEGTCLPPCCVV-------SCTPPTCCQLHHAQASCCRPSYCG 144

                         170
                  ....*....|....*
gi 111309363  233 SLLCRPVCQPACCMP 247
Cdd:pfam01500 145 QSCCRPACCCQCSEP 159
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 73-247 3.27e-09

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 54.80  E-value: 3.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111309363   73 SSCTPSCCQQSSCQPACCTSSPCQQACCMPVCCKPVCCLPTCSkdsssccqqsscqptccassssqqSCCVPVCCKPVCY 152
Cdd:pfam01500  18 GTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQ------------------------PCCQTSCCQPTCC 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111309363  153 VPTCSESSSSCCQQSSCHPACCTSspCQQACCVPVRCKPVCCKPICCVPvcsgastSCCQQSSCQPACCTTSCCRPSSSV 232
Cdd:pfam01500  74 QTSSCQTGCGGIGYGQEGSSGAVS--SRTRWCRPDCRVEGTCLPPCCVV-------SCTPPTCCQLHHAQASCCRPSYCG 144

                         170
                  ....*....|....*
gi 111309363  233 SLLCRPVCQPACCMP 247
Cdd:pfam01500 145 QSCCRPACCCQCSEP 159
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 171-282 3.07e-08

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 52.10  E-value: 3.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111309363  171 PACCTSSPCQQACCVPVRCKPVCCKPICCVPVCSGA-STSCCQQSSCQPACCTTSC--------------------CRPS 229
Cdd:pfam01500  27 PCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCcQTSCCQPTCCQTSSCQTGCggigygqegssgavssrtrwCRPD 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 111309363  230 SSVSLLCRPVCQPACCMPVSscCAPASSCQASCCRPASCVSLLCRPACSRLAC 282
Cdd:pfam01500 107 CRVEGTCLPPCCVVSCTPPT--CCQLHHAQASCCRPSYCGQSCCRPACCCQCS 157
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
72-113 6.82e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 48.15  E-value: 6.82e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 111309363   72 TSSCTPSCCQQSSCQPACCTSSPCQQACCMPVCCKPVCCLPT 113
Cdd:pfam13885   4 PSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
74-114 1.75e-07

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 46.99  E-value: 1.75e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 111309363   74 SCTPSCCQQSSCQPACCTSSPCQQACCMPVCCKPVCCLPTC 114
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSC 41
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
193-239 2.83e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 43.52  E-value: 2.83e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 111309363  193 CCKPICCVPVCSgaSTSCCQQSSCQPACCTTSCCRPSSSVSLLCRPV 239
Cdd:pfam13885   1 CCQPSCCQPSCC--QPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 25-203 3.16e-06

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 46.32  E-value: 3.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111309363   25 SCCEPHCCALSCCALAPCLTLVCTPVSRVSSPCCQAACEPspcqsgcTSSCTPSCCQQSSCQPACCTSspCQQACCMPVC 104
Cdd:pfam01500   2 ACCGTSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQ-------TSCCQPTTFQSSCCRPTCQPC--CQTSCCQPTC 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111309363  105 CKPVCCLPTCSkdSSSCCQQSSCQPTCCASSSSQQSCCVPVCCKPVCYVPTCSEssssccqqsschPACCTSSPCQQACC 184
Cdd:pfam01500  73 CQTSSCQTGCG--GIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTP------------PTCCQLHHAQASCC 138

                         170
                  ....*....|....*....
gi 111309363  185 VPVRCKPVCCKPICCVPVC 203
Cdd:pfam01500 139 RPSYCGQSCCRPACCCQCS 157
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 193-270 2.79e-05

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 43.63  E-value: 2.79e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 111309363  193 CCKPICCVPVCSGASTscCQQSSCQPACCTTSCCRPSSSVSLLCRPVC-QPACCMPVSSCCAPASSCQASCCRPASCVS 270
Cdd:pfam01500   4 CGTSFCGFPTCSTGGT--CGSGCCQPCCCQSSCCRPSCCQTSCCQPTTfQSSCCRPTCQPCCQTSCCQPTCCQTSSCQT 80
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
210-255 1.14e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 38.90  E-value: 1.14e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 111309363  210 CCQQSSCQPACCTTSCCRPSSSVSLLCRPV-CQPACCmpVSSCCAPA 255
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPScCRPSCC--RSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
171-203 2.36e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 38.13  E-value: 2.36e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 111309363  171 PACCTSSPCQQACCVPVRCKPVCCKPICCVPVC 203
Cdd:pfam13885   9 PSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSC 41
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
79-155 8.84e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 36.59  E-value: 8.84e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 111309363   79 CCQQSSCQPACCTSSPCQQACCMPVCCKPVCClptcskdsssccqqsscqptccassssqqsccVPVCCKPVCYVPT 155
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCC--------------------------------RPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
146-202 9.95e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 36.21  E-value: 9.95e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 111309363  146 CCKPVCYVPTCSEssssccqqsschPACCTSSPCQQACCVPVRCKPVCCKPICCVPV 202
Cdd:pfam13885   1 CCQPSCCQPSCCQ------------PSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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