|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
54-701 |
7.45e-171 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 510.39 E-value: 7.45e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVvGVTQPRRVAAVTVAGRVAEERGAVLGHEVG 133
Cdd:COG1643 10 LPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGGRI-GMLEPRRLAARAAAERMAEELGEPVGETVG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 134 YCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKK-RGDLRLIVASATLD 212
Cdd:COG1643 89 YRVRFEDKVSA-ATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPAlRPDLKLLVMSATLD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 213 ADKFRDFFNqnetsdPARdtcvILTVEGRTFPVDIFYL--QSPVPDYIKSTVETVVKIHQtEGDGDVLAFLTGQEEvetv 290
Cdd:COG1643 168 AERFARLLG------DAP----VIESSGRTYPVEVRYRplPADERDLEDAVADAVREALA-EEPGDILVFLPGERE---- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 291 vsmlIEQARALARTGMKRHLRVLPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDCGFVKLRAYNP 370
Cdd:COG1643 233 ----IRRTAEALRGRLPPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDP 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 371 RTAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDKLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMSP 450
Cdd:COG1643 309 RSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDP 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 451 PPAQSMVQALELLYALGGLDKDCRLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNIFvvppnqksh 530
Cdd:COG1643 389 PPARAIADARALLQELGALDADGRLT-PLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPR--------- 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 531 airvhRKFAveEGDHLTMLNIYEAFIKHnkdskwcQEHFLNYKGLVRAATVREQLKKLLvkfQVPRKSSEGDPDLVLRCI 610
Cdd:COG1643 459 -----RGAA--GSDLLARLNLWRRLREQ-------QREFLSYLRLREWRDLARQLRRLL---GEGANEEPADYEAIGLLL 521
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 611 VSGFFAN-AARFHSTGAYRTIRdDHELHIHPASVLYAEKpprWVIYNEVIQT---SKyyMRDVTAIESAWLLELAPHFYQ 686
Cdd:COG1643 522 ALAYPDRiARRRGEGGRYLLAR-GRGAALFPGSPLAKKE---WLVAAELVGGaaeAR--IRLAAPIDPEWLEELAAHLIK 595
|
650
....*....|....*
gi 124375832 687 QGTHLSLKAKRAKVQ 701
Cdd:COG1643 596 RYSEPHWDKKRGRVV 610
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
52-683 |
1.13e-150 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 470.40 E-value: 1.13e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 52 QKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGrVVGVTQPRRVAAVTVAGRVAEERGAVLGHE 131
Cdd:TIGR01967 64 DNLPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLELGRGSHG-LIGHTQPRRLAARTVAQRIAEELGTPLGEK 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 132 VGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATL 211
Cdd:TIGR01967 143 VGYKVRFHDQVSS-NTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKIIITSATI 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 212 DADKFRDFFNQNEtsdpardtcvILTVEGRTFPVDIFY-----LQSPVP-DYIKSTVETVVKIHQtEGDGDVLAFLTGQE 285
Cdd:TIGR01967 222 DPERFSRHFNNAP----------IIEVSGRTYPVEVRYrplveEQEDDDlDQLEAILDAVDELFA-EGPGDILIFLPGER 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 286 EVEtvvsmliEQARALARTGMkRHLRVLPMYAGLPSFEQMKVFErvSRSVRKVIVATNVAETSITISGIVYVIDCGFVKL 365
Cdd:TIGR01967 291 EIR-------DAAEILRKRNL-RHTEILPLYARLSNKEQQRVFQ--PHSGRRIVLATNVAETSLTVPGIHYVIDTGTARI 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 366 RAYNPRTAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDKLPQSTVPEMQRSNLAPVILQLKALGIDNVLRF 445
Cdd:TIGR01967 361 SRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSRPEFTDPEILRTNLASVILQMLALRLGDIAAF 440
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 446 HFMSPPPAQSMVQALELLYALGGLDKD---CRLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNIFV 522
Cdd:TIGR01967 441 PFIEAPDPRAIRDGFRLLEELGALDDDeaePQLT-PIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLIIASALSIQDPRE 519
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 523 VPPNQKSHAIRVHRKFAVEEGDHLTMLNIYEAF------IKHNKDSKWCQEHFLNYKGLVRAATVREQLKKLLVKFQVPR 596
Cdd:TIGR01967 520 RPMEKQQAADQAHARFKDPRSDFLSRVNLWRHIeeqrqaLSANQFRNACRKQYLNYLRVREWQDIYRQLTQVVKELGLKL 599
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 597 KSSEGDPDLVLRCIVSGFFANAARFHSTGAYRTIRdDHELHIHPASVLyAEKPPRWVIYNEVIQTSKYYMRDVTAIESAW 676
Cdd:TIGR01967 600 NEEPADYDAIHKALLSGLLSQIGMKDEKHEYDGAR-GRKFHIFPGSPL-FKKPPKWVMAAELVETSKLYARLVAKIEPEW 677
|
....*..
gi 124375832 677 LLELAPH 683
Cdd:TIGR01967 678 VEPVAGH 684
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
54-683 |
5.04e-144 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 452.98 E-value: 5.04e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGrVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVG 133
Cdd:PRK11131 73 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGRGVKG-LIGHTQPRRLAARTVANRIAEELETELGGCVG 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 134 YCIRFddcTDQLA--TRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATL 211
Cdd:PRK11131 152 YKVRF---NDQVSdnTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSATI 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 212 DADKFRDFFNQNEtsdpardtcvILTVEGRTFPVDIFYlqSPV--------PDYIKSTVETVVKIhQTEGDGDVLAFLTG 283
Cdd:PRK11131 229 DPERFSRHFNNAP----------IIEVSGRTYPVEVRY--RPIveeaddteRDQLQAIFDAVDEL-GREGPGDILIFMSG 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 284 QEEVEtvvsmliEQARALARTGMkRHLRVLPMYAGLPSFEQMKVFErvSRSVRKVIVATNVAETSITISGIVYVIDCGFV 363
Cdd:PRK11131 296 EREIR-------DTADALNKLNL-RHTEILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTA 365
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 364 KLRAYNPRTAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDKLPQSTVPEMQRSNLAPVILQLKALGIDNVL 443
Cdd:PRK11131 366 RISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIA 445
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 444 RFHFMSPPPAQSMVQALELLYALGGLDKDC-----RLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQ 518
Cdd:PRK11131 446 AFPFVEAPDKRNIQDGVRLLEELGAITTDEqasayKLT-PLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQ 524
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 519 NIFVVPPNQKSHAIRVHRKFAVEEGDHLTMLNIYEaFIK-------HNKDSKWCQEHFLNYkglVRaatVRE------QL 585
Cdd:PRK11131 525 DPRERPMDKQQASDEKHRRFADKESDFLAFVNLWN-YLQeqqkalsSNQFRRLCRTDYLNY---LR---VREwqdiytQL 597
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 586 KKLLVKFQVPRKSSEGDPDLVLRCIVSGFFA-----NAARFHSTGAyrtiRDDHeLHIHPASVLYaEKPPRWVIYNEVIQ 660
Cdd:PRK11131 598 RQVVKELGIPVNSEPAEYREIHTALLTGLLShigmkDAEKQEYTGA----RNAR-FSIFPGSGLF-KKPPKWVMVAELVE 671
|
650 660
....*....|....*....|...
gi 124375832 661 TSKYYMRDVTAIESAWLLELAPH 683
Cdd:PRK11131 672 TSRLWGRIAARIEPEWIEPLAQH 694
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
54-238 |
2.93e-133 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 390.29 E-value: 2.93e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVG 133
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGWTAGGRVVGCTQPRRVAAVTVAGRVAEEMGAVLGHEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 134 YCIRFDDCTDQLATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDA 213
Cdd:cd17980 81 YCIRFDDCTDPQATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASATLDA 160
|
170 180
....*....|....*....|....*
gi 124375832 214 DKFRDFFNQNETSDPARDTCVILTV 238
Cdd:cd17980 161 EKFRDFFNQNETNDPSKDTATILSV 185
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
54-520 |
1.40e-95 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 313.63 E-value: 1.40e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPqyLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVG 133
Cdd:TIGR01970 1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVP--LALLDAPGIGGKIIMLEPRRLAARSAAQRLASQLGEAVGQTVG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 134 YCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKK-RGDLRLIVASATLD 212
Cdd:TIGR01970 79 YRVRGENKVSR-RTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVQSSlREDLKILAMSATLD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 213 ADKFRDFFNQnetsdpardtCVILTVEGRTFPVDIFYLQSPVPDYIKSTVETVVKIHQTEGDGDVLAFLTGQEEVETVVS 292
Cdd:TIGR01970 158 GERLSSLLPD----------APVVESEGRSFPVEIRYLPLRGDQRLEDAVSRAVEHALASETGSILVFLPGQAEIRRVQE 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 293 MLIEQARAlartgmkrHLRVLPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDCGFVKLRAYNPRT 372
Cdd:TIGR01970 228 QLAERLDS--------DVLICPLYGELSLAAQDRAIKPDPQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKT 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 373 AIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDKLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMSPPP 452
Cdd:TIGR01970 300 GITRLETVRISQASATQRAGRAGRLEPGVCYRLWSEEQHQRLPAQDEPEILQADLSGLALELAQWGAKDPSDLRWLDAPP 379
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124375832 453 AQSMVQALELLYALGGLDKDCRLTEpLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNI 520
Cdd:TIGR01970 380 SVALAAARQLLQRLGALDAQGRLTA-HGKAMAALGCHPRLAAMLLSAHSTGLAALACDLAALLEERGL 446
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
54-221 |
4.42e-84 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 263.06 E-value: 4.42e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGwTAEGRVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVG 133
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAG-FARGGMIGITQPRRVAAVSVAKRVAEEMGVELGQLVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 134 YCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGD-----LRLIVAS 208
Cdd:cd17978 80 YSVRFDDVTSE-ETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRKEqklspLKVIIMS 158
|
170
....*....|...
gi 124375832 209 ATLDADKFRDFFN 221
Cdd:cd17978 159 ATLDADLFSEYFN 171
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
71-222 |
1.67e-82 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 258.16 E-value: 1.67e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 71 QTVVIVGETGCGKSTQIPQYLAEAGWTAEGRV-VGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQlATRI 149
Cdd:cd17917 2 QVVVIVGETGSGKTTQVPQFLLEDGLAKGGKGrIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSS-KTRI 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124375832 150 KFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFFNQ 222
Cdd:cd17917 81 KFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGG 153
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
54-514 |
1.90e-78 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 267.18 E-value: 1.90e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIP-QYLAEAGWTaeGRVVgVTQPRRVAAVTVAGRVAEERGAVLGHEV 132
Cdd:PRK11664 4 LPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPlQLLQHGGIN--GKII-MLEPRRLAARNVAQRLAEQLGEKPGETV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 133 GYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKK-RGDLRLIVASATL 211
Cdd:PRK11664 81 GYRMRAESKVGP-NTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQGlRDDLKLLIMSATL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 212 DADKFRDFFnqnetsdParDTCVILTvEGRTFPVDIFYLQSPVPDYIKSTVETVVKIHQTEGDGDVLAFLTGQEEVETVV 291
Cdd:PRK11664 160 DNDRLQQLL-------P--DAPVIVS-EGRSFPVERRYQPLPAHQRFDEAVARATAELLRQESGSLLLFLPGVGEIQRVQ 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 292 SMLIEQaralartgMKRHLRVLPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDCGFVKLRAYNPR 371
Cdd:PRK11664 230 EQLASR--------VASDVLLCPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPK 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 372 TAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDKLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMSPP 451
Cdd:PRK11664 302 TGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLLLELLQWGCHDPAQLSWLDQP 381
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124375832 452 PAQSMVQALELLYALGGLDKDCRLTePLGMRIAEFPLNPMFAKMLLESGNFgcSQEILSIAAM 514
Cdd:PRK11664 382 PAAALAAAKRLLQQLGALDGQGRLT-ARGRKMAALGNDPRLAAMLVAAKED--DEAALATAAK 441
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
49-220 |
9.13e-78 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 246.63 E-value: 9.13e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 49 QQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVvGVTQPRRVAAVTVAGRVAEERGAVL 128
Cdd:cd17971 1 EQRESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTSRGKI-GCTQPRRVAAMSVAKRVAEEFGCCL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 129 GHEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVAS 208
Cdd:cd17971 80 GQEVGYTIRFEDCTSP-ETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIVTS 158
|
170
....*....|..
gi 124375832 209 ATLDADKFRDFF 220
Cdd:cd17971 159 ATLDAVKFSQYF 170
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
243-406 |
2.11e-75 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 240.13 E-value: 2.11e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 243 FPVDIFYLQSPV-----------PDYIKSTVETVVKIHQTEGDGDVLAFLTGQEEVETVVSMLieqaRALARTGMKRHLR 311
Cdd:cd18791 1 FPVEVYYLEDILellgissekedPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELL----REELLSPDLGKLL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 312 VLPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQRA 391
Cdd:cd18791 77 VLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRA 156
|
170
....*....|....*
gi 124375832 392 GRGGRSRSGKCYRLY 406
Cdd:cd18791 157 GRAGRTRPGKCYRLY 171
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
45-221 |
3.24e-74 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 237.70 E-value: 3.24e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 45 LSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWT-AEGRVVGVTQPRRVAAVTVAGRVAEE 123
Cdd:cd17973 4 FEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPhQPKKLVACTQPRRVAAMSVAQRVAEE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 124 RGAVLGHEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLR 203
Cdd:cd17973 84 MDVKLGEEVGYSIRFEDCSSA-KTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPDLK 162
|
170
....*....|....*...
gi 124375832 204 LIVASATLDADKFRDFFN 221
Cdd:cd17973 163 LIVMSATLDAGKFQKYFD 180
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
54-222 |
7.76e-74 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 236.25 E-value: 7.76e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVG 133
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGGKIGCTQPRRVAAMSVAARVAEEMGVKLGNEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 134 YCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDA 213
Cdd:cd17974 81 YSIRFEDCTSE-KTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSATMDA 159
|
....*....
gi 124375832 214 DKFRDFFNQ 222
Cdd:cd17974 160 EKFSAFFDD 168
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
54-220 |
6.32e-68 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 220.41 E-value: 6.32e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGrVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVG 133
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYTDYG-MIGCTQPRRVAAMSVAKRVSEEMGVELGEEVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 134 YCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDA 213
Cdd:cd17983 80 YAIRFEDCTSE-NTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSATMDA 158
|
....*..
gi 124375832 214 DKFRDFF 220
Cdd:cd17983 159 DKFADFF 165
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
54-218 |
2.95e-61 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 203.35 E-value: 2.95e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAE----GRVVGVTQPRRVAAVTVAGRVAEERGaVLG 129
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPesdnPGMIGITQPRRVAAVSMAKRVAEELN-VFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 130 HEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGD-------- 201
Cdd:cd17982 80 KEVSYQIRYDSTVSE-NTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdqtv 158
|
170
....*....|....*....
gi 124375832 202 --LRLIVASATLDADKFRD 218
Cdd:cd17982 159 kpLKLVIMSATLRVEDFTE 177
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
54-220 |
2.01e-57 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 192.76 E-value: 2.01e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVvGVTQPRRVAAVTVAGRVAEERGAVLGHEVG 133
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHGMI-GVTQPRRVAAISVAQRVAEEMKCTLGSKVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 134 YCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKI--QKKRG---DLRLIVAS 208
Cdd:cd17984 80 YQVRFDDCSSK-ETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLfqEKSPNrkeHLKVVVMS 158
|
170
....*....|..
gi 124375832 209 ATLDADKFRDFF 220
Cdd:cd17984 159 ATLELAKLSAFF 170
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
54-222 |
6.45e-51 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 174.55 E-value: 6.45e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAegrvVGVTQPRRVAAVTVAGRVAEERGAVLGHEVG 133
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRH----IACTQPRRIACISLAKRVAFESLNQYGSKVA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 134 YCIRFDDcTDQLATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDA 213
Cdd:cd17979 77 YQIRFER-TRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSATINI 155
|
....*....
gi 124375832 214 DKFRDFFNQ 222
Cdd:cd17979 156 ELFSGYFEG 164
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
54-221 |
6.15e-50 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 172.25 E-value: 6.15e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGrVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVG 133
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGRGIRG-LIGHTQPRRLAARSVAERIAEELKTELGGAVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 134 YCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDA 213
Cdd:cd17989 80 YKVRFTDQTSD-ETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSATIDA 158
|
....*...
gi 124375832 214 DKFRDFFN 221
Cdd:cd17989 159 ERFSRHFN 166
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
54-221 |
2.54e-46 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 162.70 E-value: 2.54e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYL----AEAGWTAEGRVVgVTQPRRVAAVTVAGRVAEERG--AV 127
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFIlddaIERGKGSSCRIV-CTQPRRISAISVAERVAAERAesCG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 128 LGHEVGYCIRFDDCTDQLATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVA 207
Cdd:cd17981 80 LGNSTGYQIRLESRKPRKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILM 159
|
170
....*....|....
gi 124375832 208 SATLDADKFRDFFN 221
Cdd:cd17981 160 SATLNAEKFSDYFN 173
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
54-222 |
1.80e-43 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 154.69 E-value: 1.80e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAE----AGWTAEGRVVGVTQPRRVAAVTVAGRVAEERGAVLG 129
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEdlllNGGTAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 130 -----HEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRL 204
Cdd:cd17975 81 pggknSLCGYQIRMESRTGE-ATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHL 159
|
170
....*....|....*...
gi 124375832 205 IVASATLDADKFRDFFNQ 222
Cdd:cd17975 160 ILMSATVDCEKFSSYFTH 177
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
54-221 |
5.14e-43 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 153.46 E-value: 5.14e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGW-TAEGRVVGV--TQPRRVAAVTVAGRVAEERGAVLGH 130
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLqGPPLPVANIicTQPRRISAISVAERVAQERAERVGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 131 EVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASAT 210
Cdd:cd17985 81 SVGYQIRLESVKSS-ATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSAT 159
|
170
....*....|.
gi 124375832 211 LDADKFRDFFN 221
Cdd:cd17985 160 LNAELFSDYFN 170
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
7-220 |
1.28e-40 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 148.44 E-value: 1.28e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 7 PVKFWRPGT-----EGPGVSISEERQSLA-ENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETG 80
Cdd:cd17972 6 PQSNWNPWTssnidEGPLAFATPEQISMDlKNELMYQREQDHNLQQILQERELLPVKKFREEILEAISNNPVVIIRGATG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 81 CGKSTQIPQYLAE----AGWTAEGRVVgVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQLATRIKFLTDGM 156
Cdd:cd17972 86 CGKTTQVPQYILDdfiqNDRAAECNIV-VTQPRRISAVSVAERVAFERGEEVGKSCGYSVRFESVLPRPHASILFCTVGV 164
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124375832 157 LVREMmvDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFF 220
Cdd:cd17972 165 LLRKL--EAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYF 226
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
54-216 |
2.08e-40 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 145.94 E-value: 2.08e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVgVTQPRRVAAVTVAGRVAEERGAVLGHEVG 133
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGGKII-VLEPRRVAARAAARRLATLLGEAPGETVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 134 YCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQK-KRGDLRLIVASATLD 212
Cdd:cd17990 80 YRVRGESRVGR-RTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQlLRDDLRLLAMSATLD 158
|
....
gi 124375832 213 ADKF 216
Cdd:cd17990 159 GDGL 162
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
54-209 |
4.69e-38 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 139.58 E-value: 4.69e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGR--VVGVTQPRRVAAVTVAGRVAEERGAVLGHE 131
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCLSAHYQhgVVVCTQVHKQTAVWLALRVADEMDVNIGHE 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124375832 132 VGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASA 209
Cdd:cd17977 81 VGYVIPFENCCTN-ETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITC 157
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
54-220 |
5.97e-38 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 139.16 E-value: 5.97e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAE----AGWTAEGRVVgVTQPRRVAAVTVAGRVAEERGAVLG 129
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEdyvlRGRGARCNVV-ITQPRRISAVSVAQRVAHELGPNLR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 130 HEVGYCIRFDDCTDQLATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASA 209
Cdd:cd17976 80 RNVGYQVRLESRPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSA 159
|
170
....*....|.
gi 124375832 210 TLDADKFRDFF 220
Cdd:cd17976 160 TGDNQRLSRYF 170
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
54-219 |
1.15e-37 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 138.49 E-value: 1.15e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 54 LPVFKLRNHILYLIENYQTVVIV-GETGCGKSTQIPQYLAEAGWT---AEGRVVgVTQPRRVAAVTVAGRVAEERGAVLG 129
Cdd:cd17986 1 LPIWAAKFTFLEQLESPSGIVLVsGEPGSGKSTQVPQWCAEFALSrgfQKGQVT-VTQPHPLAARSLALRVADEMDLNLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 130 HEVGYCIRFDDCTDQlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASA 209
Cdd:cd17986 80 HEVGYSIPQEDCTGP-NTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVTS 158
|
170
....*....|
gi 124375832 210 TLDADKFRDF 219
Cdd:cd17986 159 PALEPKLRAF 168
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
54-221 |
1.98e-36 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 134.96 E-value: 1.98e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGW-TAEGRVVGVTQPRRVAAVTVAGRVAEERGAVLGHEV 132
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYaNGIPCRIFCTQPRRLAAIAVAERVAAERGEKIGQTV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 133 GYCIRFDDCTDQlATRIKFLTDGMLVREMMV-DPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATL 211
Cdd:cd17987 81 GYQIRLESRVSP-KTLLTFCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSAAL 159
|
170
....*....|
gi 124375832 212 DADKFRDFFN 221
Cdd:cd17987 160 DVNLFIRYFG 169
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
54-220 |
4.02e-32 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 122.61 E-value: 4.02e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 54 LPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQY-LAEAGWTAEGRVVGVTQPRRVAAVTVAGRVAEERGAVLGHEV 132
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFiLDHYYKRGKYCNIVVTQPRRIAAISIARRVSQEREWTLGSLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 133 GYCIRFDDcTDQLATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKK-IQKKRGDLRLIVASATL 211
Cdd:cd17988 81 GYQVGLER-PASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRlLRTNSRHVKIILMSATI 159
|
....*....
gi 124375832 212 DADKFRDFF 220
Cdd:cd17988 160 SCKEFADYF 168
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
459-548 |
1.05e-26 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 104.63 E-value: 1.05e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 459 ALELLYALGGLDKDCRLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNIFVVP----PNQKSHAIRV 534
Cdd:pfam04408 1 ALELLYYLGALDEDGELT-PLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPnfldPRSAAKAARR 79
|
90 100
....*....|....*....|....*
gi 124375832 535 HRKFAVEE-----------GDHLTM 548
Cdd:pfam04408 80 RRRAADEKarakfarldleGDHLTL 104
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
465-549 |
7.80e-25 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 98.49 E-value: 7.80e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 465 ALGGLDKDCRLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNIFvvPPNQKSHAIRVHRKFAVEEGD 544
Cdd:smart00847 1 ELGALDDDGRLT-PLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFADPESD 77
|
....*
gi 124375832 545 HLTML 549
Cdd:smart00847 78 HLTLL 82
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
606-683 |
1.62e-21 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 88.85 E-value: 1.62e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 606 VLRCIVSGFFANAARF-HSTGAYRTIRDDHELHIHPASVLY--AEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAP 682
Cdd:pfam07717 1 LRAALAAGLYPNVARRdPKGKGYTTLSDNQRVFIHPSSVLFneKTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLFAP 80
|
.
gi 124375832 683 H 683
Cdd:pfam07717 81 H 81
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
53-224 |
1.09e-18 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 84.85 E-value: 1.09e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 53 KLPVFKLRNH----ILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVAEERGAVL 128
Cdd:smart00487 3 KFGFEPLRPYqkeaIEALLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 129 GHEVGYcIRFDDCTDQLA------TRIKFLTDGMLVREMMVDPL-LTKYSVIMLDEAHERT--LYTDIAIGLLKKIQKKR 199
Cdd:smart00487 83 LKVVGL-YGGDSKREQLRklesgkTDILVTTPGRLLDLLENDKLsLSNVDLVILDEAHRLLdgGFGDQLEKLLKLLPKNV 161
|
170 180
....*....|....*....|....*..
gi 124375832 200 gdlRLIVASATL--DADKFRDFFNQNE 224
Cdd:smart00487 162 ---QLLLLSATPpeEIENLLELFLNDP 185
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
301-396 |
7.27e-14 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 67.24 E-value: 7.27e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 301 LARTGMKRHLRVLPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDCGFvklraynprtaieclvvv 380
Cdd:smart00490 3 LAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDL------------------ 64
|
90
....*....|....*.
gi 124375832 381 PVSQASANQRAGRGGR 396
Cdd:smart00490 65 PWSPASYIQRIGRAGR 80
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
262-396 |
1.47e-12 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 64.54 E-value: 1.47e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 262 VETVVKIHQTEGDGDVLAFLTGQEEVETvvSMLIEqaralartgmKRHLRVLPMYAGLPSFEQMKVFERVSRSVRKVIVA 341
Cdd:pfam00271 3 LEALLELLKKERGGKVLIFSQTKKTLEA--ELLLE----------KEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVA 70
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 124375832 342 TNVAETSITISGIVYVIDCGFVklraYNPRTAIeclvvvpvsqasanQRAGRGGR 396
Cdd:pfam00271 71 TDVAERGLDLPDVDLVINYDLP----WNPASYI--------------QRIGRAGR 107
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
41-407 |
1.29e-09 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 61.53 E-value: 1.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 41 PYAALSIEQQRQklpVFKLrnhilyLIENYQtVVIVGETGCGKSTQIPQ------YLAeAGWTAEGRVVGVTQPRRVaaV 114
Cdd:PHA02653 160 PLASLQPDVQLK---IFEA------WISRKP-VVLTGGTGVGKTSQVPKlllwfnYLF-GGFDNLDKIDPNFIERPI--V 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 115 TVAGRVAEER--GAVLGHEVGY--------CIRFDDCTDQLA-TRIKFltDGMLVRemmVDPL----LTKYSVIMLDEAH 179
Cdd:PHA02653 227 LSLPRVALVRlhSITLLKSLGFdeidgspiSLKYGSIPDELInTNPKP--YGLVFS---THKLtlnkLFDYGTVIIDEVH 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 180 ERTLYTDIAIGLLKkiqKKRGDLR-LIVASATL--DADKFRDFFNqnetsDPArdtcvILTVEGRT-FPVDIFYL---QS 252
Cdd:PHA02653 302 EHDQIGDIIIAVAR---KHIDKIRsLFLMTATLedDRDRIKEFFP-----NPA-----FVHIPGGTlFPISEVYVknkYN 368
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 253 PvPDYIKSTVETVVKIHQTEGDGDVLAFLTGQEEVETvVSMLIEQARALArtgmKRH--LRVLPMYAGLPSFEQM--KVF 328
Cdd:PHA02653 369 P-KNKRAYIEEEKKNIVTALKKYTPPKGSSGIVFVAS-VSQCEEYKKYLE----KRLpiYDFYIIHGKVPNIDEIleKVY 442
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 329 --ERVSrsvrkVIVATNVAETSITISGIVYVIDCGfvklRAYNPRtaieclvvvP-------VSQASANQRAGRGGRSRS 399
Cdd:PHA02653 443 ssKNPS-----IIISTPYLESSVTIRNATHVYDTG----RVYVPE---------PfggkemfISKSMRTQRKGRVGRVSP 504
|
....*...
gi 124375832 400 GKCYRLYT 407
Cdd:PHA02653 505 GTYVYFYD 512
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
73-210 |
2.27e-07 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 50.48 E-value: 2.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 73 VVIVGETGCGKSTQIPQYLAEAGWTAEGRVVgVTQPRRVAAVTVAGRVAEERG-----AVLGHEVGYCIRFDDCTDQLat 147
Cdd:cd00046 4 VLITAPTGSGKTLAALLAALLLLLKKGKKVL-VLVPTKALALQTAERLRELFGpgirvAVLVGGSSAEEREKNKLGDA-- 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124375832 148 RIKFLTDGMLVREMMVDPLLT--KYSVIMLDEAHeRTLYTD--IAIGLLKKIQKKRGDLRLIVASAT 210
Cdd:cd00046 81 DIIIATPDMLLNLLLREDRLFlkDLKLIIVDEAH-ALLIDSrgALILDLAVRKAGLKNAQVILLSAT 146
|
|
| DEXHc_viral_Ns3 |
cd17931 |
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ... |
71-210 |
1.08e-06 |
|
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350689 [Multi-domain] Cd Length: 151 Bit Score: 48.70 E-value: 1.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 71 QTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVgVTQPRRVAAvtvagrvAEERGAVLGHEVGYCIRFDDCTDQLATRIK 150
Cdd:cd17931 2 QLTVLDLHPGAGKTTRVLPQIIREAIKKRLRTL-VLAPTRVVA-------AEMYEALRGLPIRYRTGAVKEEHGGNEIVD 73
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 151 FLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKiQKKRGDLRLIVASAT 210
Cdd:cd17931 74 YMCHGTFTCRLLSPKRVPNYNLIIMDEAHFTDPASIAARGYIHT-RVEMGEAAVIFMTAT 132
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
261-411 |
2.89e-04 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 44.09 E-value: 2.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 261 TVETVVKIHQTEGDGDVLAFLTGQEEVETVVSMLIE----------QARALARTGMKRHlrvlpmyaglpsfEQMKVFER 330
Cdd:PRK13766 352 LREIVKEQLGKNPDSRIIVFTQYRDTAEKIVDLLEKegikavrfvgQASKDGDKGMSQK-------------EQIEILDK 418
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 331 VSRSVRKVIVATNVAETSITISGIVYVIdcgFvklraYNPrtaieclvvVPvSQASANQRAGRGGRSRSGKCYRLYTE-- 408
Cdd:PRK13766 419 FRAGEFNVLVSTSVAEEGLDIPSVDLVI---F-----YEP---------VP-SEIRSIQRKGRTGRQEEGRVVVLIAKgt 480
|
....*
gi 124375832 409 --EAF 411
Cdd:PRK13766 481 rdEAY 485
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
329-406 |
1.13e-03 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 38.07 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 329 ERVSRSVrKVIVATNVAETSITISGIVYVIDCGFVKlraynprtaieclvvvpvSQASANQRAGRGGR--SRSGKCYRLY 406
Cdd:cd18785 17 EEIASSL-EILVATNVLGEGIDVPSLDTVIFFDPPS------------------SAASYIQRVGRAGRggKDEGEVILFV 77
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
73-214 |
2.78e-03 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 39.15 E-value: 2.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375832 73 VVIVGETGCGKST--QIPqYLAEAGWTAEGRVVGVTQPRRVAAVTVAgRVAEERGAVLGHEVGYCIRFDDCTDQLA---- 146
Cdd:pfam00270 17 VLVQAPTGSGKTLafLLP-ALEALDKLDNGPQALVLAPTRELAEQIY-EELKKLGKGLGLKVASLLGGDSRKEQLEklkg 94
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124375832 147 TRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHeRTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAD 214
Cdd:pfam00270 95 PDILVGTPGRLLDLLQERKLLKNLKLLVLDEAH-RLLDMGFGPDLEEILRRLPKKRQILLLSATLPRN 161
|
|
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