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Conserved domains on  [gi|187950339|gb|AAI36364|]
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Sarcosine dehydrogenase [Homo sapiens]

Protein Classification

FAD-dependent oxidoreductase( domain architecture ID 11429831)

FAD-dependent oxidoreductase containing a GcvT (glycine cleavage system T) domain such as sarcosine dehydrogenase and dimethylglycine dehydrogenase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 480-916 1.07e-104

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


:

Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 329.35  E-value: 1.07e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 480 GRNMRRDPLHEELLGQGCVFQERHGWERPGWFHprgpapvleydyygaygsrahedyayrrlladeytfafpphhDTIKK 559
Cdd:COG0404    1 FRPLRRTPLHDRHVALGAKFVDFGGWEMPVQYP------------------------------------------GGVIA 38

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 560 ECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGSTVYTCMLNHRGGTESDLTVSRLAPshqasplapa 638
Cdd:COG0404   39 EHLAVREAVGLFDVSHMGKIEVTGPDAAAFLDRLVTNDVSKlKPGRARYTLMLNEDGGIIDDLTVYRLGE---------- 108

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 639 fegDGYYLAMGGAVAQHNWSHITTVLQDQKSqCQLIDSSEDLGMISIQGPASRAILQEVLDADLSneAFPFSTHKLLRAA 718
Cdd:COG0404  109 ---DRFLLVVNAANAAKDLAWLEEHLPPDFD-VTITDVTDDWALLAVQGPKAREVLAKLTDADLS--ALPFMSFREGTVA 182

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 719 GHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAGAKHGLINAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFT 798
Cdd:COG0404  183 GVPVRVSRTGYTGEDGFEIYVPAEDAEALWDALLEAGEEFGVKPCGLGARDTLRLEAGYPLYGHELDETTTPLEAGLGWA 262

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 799 CKLKSPvPFLGREALEQQRAAGLRRRLVCFTMEDKVPMFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYIHDpsggpv 878
Cdd:COG0404  263 VKLDKG-DFIGKEALLRQKEEGPRRKLVGLELDGRGVPRAGAPVLADGEVVGEVTSGTFSPTLGKSIALAYVPA------ 335

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 187950339 879 slDFVKSGD-YALERMGVTYGAQAHLKSPFDPNNKRVKG 916
Cdd:COG0404  336 --GLARPGTeLEVEIRGKRVPAEVVKPPFYDPEGERLRG 372
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
66-444 1.79e-84

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


:

Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 275.63  E-value: 1.79e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  66 TANVVVIGGGSLGCQTLYHLAKLGMSgAVLLERERLTSGTTWHTAGLLWQLRPSDVEVELLAHTRRVVS--RELEEETGL 143
Cdd:COG0665    2 TADVVVIGGGIAGLSTAYHLARRGLD-VTVLERGRPGSGASGRNAGQLRPGLAALADRALVRLAREALDlwRELAAELGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 144 HTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARA 223
Cdd:COG0665   81 DCDFRRTGVLYLARTEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLYDPDDGHVDPAKLVRALARA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 224 ASARGAQVIENCPVTGIRVwTDDfgvrRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTERIEG 303
Cdd:COG0665  161 ARAAGVRIREGTPVTGLER-EGG----RVTGVRTERGTVRADAVVLAAGAWSARLLPMLGLRLPLRPVRGYVLVTEPLPD 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 304 IQNMPNVRDHDasVYLRLQGD-ALSVGGyeanpifweevSDKFAFGLFDLDWEVFTQHIEGAINRVPVLEKTGIKSTVCG 382
Cdd:COG0665  236 LPLRPVLDDTG--VYLRPTADgRLLVGG-----------TAEPAGFDRAPTPERLEALLRRLRRLFPALADAEIVRAWAG 302

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 187950339 383 PESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRR 444
Cdd:COG0665  303 LRPMTPDGLPIIGRLPGAPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPDR 364
FAO_M pfam16350
FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent ...
 430-485 2.85e-21

FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent oxidoreductases: Sarcosine dehydrogenase, Dimethylglycine dehydrogenase and Dimethylglycine dehydrogenase. It is situated between the DAO domain (pfam01266) and the GCV_T domain (pfam01571).


:

Pssm-ID: 465100  Cd Length: 56  Bit Score: 87.89  E-value: 2.85e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 187950339  430 HGRPEKDMHGYDIRRFHHsLTDHPRWIRERSHESYAKNYSVVFPHDEPLAGRNMRR 485
Cdd:pfam16350   1 DGEPPIDLWECDIRRFGP-HQNNREYLRERVAENYGEVYDIHHPNEEREAGRPLRT 55
 
Name Accession Description Interval E-value
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 480-916 1.07e-104

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 329.35  E-value: 1.07e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 480 GRNMRRDPLHEELLGQGCVFQERHGWERPGWFHprgpapvleydyygaygsrahedyayrrlladeytfafpphhDTIKK 559
Cdd:COG0404    1 FRPLRRTPLHDRHVALGAKFVDFGGWEMPVQYP------------------------------------------GGVIA 38

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 560 ECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGSTVYTCMLNHRGGTESDLTVSRLAPshqasplapa 638
Cdd:COG0404   39 EHLAVREAVGLFDVSHMGKIEVTGPDAAAFLDRLVTNDVSKlKPGRARYTLMLNEDGGIIDDLTVYRLGE---------- 108

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 639 fegDGYYLAMGGAVAQHNWSHITTVLQDQKSqCQLIDSSEDLGMISIQGPASRAILQEVLDADLSneAFPFSTHKLLRAA 718
Cdd:COG0404  109 ---DRFLLVVNAANAAKDLAWLEEHLPPDFD-VTITDVTDDWALLAVQGPKAREVLAKLTDADLS--ALPFMSFREGTVA 182

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 719 GHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAGAKHGLINAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFT 798
Cdd:COG0404  183 GVPVRVSRTGYTGEDGFEIYVPAEDAEALWDALLEAGEEFGVKPCGLGARDTLRLEAGYPLYGHELDETTTPLEAGLGWA 262

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 799 CKLKSPvPFLGREALEQQRAAGLRRRLVCFTMEDKVPMFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYIHDpsggpv 878
Cdd:COG0404  263 VKLDKG-DFIGKEALLRQKEEGPRRKLVGLELDGRGVPRAGAPVLADGEVVGEVTSGTFSPTLGKSIALAYVPA------ 335

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 187950339 879 slDFVKSGD-YALERMGVTYGAQAHLKSPFDPNNKRVKG 916
Cdd:COG0404  336 --GLARPGTeLEVEIRGKRVPAEVVKPPFYDPEGERLRG 372
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
66-444 1.79e-84

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 275.63  E-value: 1.79e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  66 TANVVVIGGGSLGCQTLYHLAKLGMSgAVLLERERLTSGTTWHTAGLLWQLRPSDVEVELLAHTRRVVS--RELEEETGL 143
Cdd:COG0665    2 TADVVVIGGGIAGLSTAYHLARRGLD-VTVLERGRPGSGASGRNAGQLRPGLAALADRALVRLAREALDlwRELAAELGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 144 HTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARA 223
Cdd:COG0665   81 DCDFRRTGVLYLARTEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLYDPDDGHVDPAKLVRALARA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 224 ASARGAQVIENCPVTGIRVwTDDfgvrRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTERIEG 303
Cdd:COG0665  161 ARAAGVRIREGTPVTGLER-EGG----RVTGVRTERGTVRADAVVLAAGAWSARLLPMLGLRLPLRPVRGYVLVTEPLPD 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 304 IQNMPNVRDHDasVYLRLQGD-ALSVGGyeanpifweevSDKFAFGLFDLDWEVFTQHIEGAINRVPVLEKTGIKSTVCG 382
Cdd:COG0665  236 LPLRPVLDDTG--VYLRPTADgRLLVGG-----------TAEPAGFDRAPTPERLEALLRRLRRLFPALADAEIVRAWAG 302

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 187950339 383 PESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRR 444
Cdd:COG0665  303 LRPMTPDGLPIIGRLPGAPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPDR 364
GCV_T pfam01571
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, ...
 489-798 6.42e-67

Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 460255  Cd Length: 254  Bit Score: 224.01  E-value: 6.42e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  489 HEELLGQGCVFQERHGWERPGWFHPRGpapvleydyygaygsrahedyayrrlladeytfafpphhdtIKKECLACRGAA 568
Cdd:pfam01571   1 YDRHVALGAKFVEFAGWEMPVQYGSNG-----------------------------------------ILAEHRAVREAA 39

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  569 AVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGSTVYTCMLNHRGGTESDLTVSRLAPSHqasplapafegdgYYLA 647
Cdd:pfam01571  40 GLFDVSHMGKIEVSGPDAAAFLQRLTTNDVSKlKPGRATYTLMLNERGGVIDDLTVYRLGDDH-------------FLLV 106

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  648 MGGAVAQHNWSHITTVLQdqKSQCQLIDSSEDLGMISIQGPASRAILQEVLDADLsNEAFPFSTHKLLRAAGHLVRAMRL 727
Cdd:pfam01571 107 VNAANREKDLAWLRKHAE--KLDVVVVDVTDDYALLALQGPKAREVLEKLTDGDL-LEALPFFSFREIEIGGVPVRVSRT 183

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 187950339  728 SFVGELGWELHIPKASCVPVYRAVMAAGAKHGLINAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFT 798
Cdd:pfam01571 184 GYTGEDGFEIYVPAEDAVELWEALLEAGAELGLRPAGLGARDSLRLEAGLPLYGHDLDEETTPLEAGLGWA 254
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 69-427 7.90e-60

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 207.64  E-value: 7.90e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339   69 VVVIGGGSLGCQTLYHLAKLGMSgAVLLERE-RLTSGTTWHTAGLLWQLR---PSDVEVELLAHTRRVVsRELEEETGLH 144
Cdd:pfam01266   2 VVVIGGGIVGLSTAYELARRGLS-VTLLERGdDPGSGASGRNAGLIHPGLrylEPSELARLALEALDLW-EELEEELGID 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  145 TGWIQNGGLFIASNrQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPLmnVDDLYGTLYVPHDGTMDPAGTCTTLARAA 224
Cdd:pfam01266  80 CGFRRCGVLVLARD-EEEEALEKLLAALRRLGVPAELLDAEELRELEPL--LPGLRGGLFYPDGGHVDPARLLRALARAA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  225 SARGAQVIENCPVTGIRVWTDDFGVRrvagvetQHGSIQtpCVVNCAGVWASAVgRMAGVKVPLVAMHHAYVVTERIEGI 304
Cdd:pfam01266 157 EALGVRIIEGTEVTGIEEEGGVWGVV-------TTGEAD--AVVNAAGAWADLL-ALPGLRLPVRPVRGQVLVLEPLPEA 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  305 QN---MPNVRDHDASVYLRLQGD-ALSVGGYEanpifweevsDKFAFGLFDLDWEVFTQHIEGAINRVPVLEKtgIKSTV 380
Cdd:pfam01266 227 LLilpVPITVDPGRGVYLRPRADgRLLLGGTD----------EEDGFDDPTPDPEEIEELLEAARRLFPALAD--IERAW 294

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 187950339  381 CGPESfTPDHKPLMGEaPELRGFFLGCGFNSAGMMLGGGCGQELAHW 427
Cdd:pfam01266 295 AGLRP-LPDGLPIIGR-PGSPGLYLATGHGGHGLTLAPGIGKLLAEL 339
gcvT PRK00389
glycine cleavage system aminomethyltransferase GcvT;
551-881 4.56e-50

glycine cleavage system aminomethyltransferase GcvT;


Pssm-ID: 234742 [Multi-domain]  Cd Length: 359  Bit Score: 180.70  E-value: 4.56e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 551 PPHHDTIKKECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGSTVYTCMLNHRGGTESDLTVSRLAPs 629
Cdd:PRK00389  27 PVQYGSIIEEHHAVRTDAGLFDVSHMGEVDVTGPDALAFLQYLLANDVSKlKPGKAQYTCMLNEDGGVIDDLIVYKLSE- 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 630 hqasplapafegDGYYLAMGGAVAQHNWSHITTVLQDQKsqCQLIDSSEDLGMISIQGPASRAILQEVLDADLSnEAFPF 709
Cdd:PRK00389 106 ------------DEYLLVVNAANREKDLAWIKSHAAGFG--VEVTDRSDDLAMIAVQGPKAREKLQKLTDADLS-ELKPF 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 710 STHKLLRAAGHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAGAKH-GLInagyrAIDSLSIEKGYR-HWHaDLRPD 787
Cdd:PRK00389 171 FGAQGAEVGGGDVLVARTGYTGEDGFEIYLPAEDAEALWDALLEAGVKPcGLG-----ARDTLRLEAGMPlYGQ-DMDET 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 788 DSPLEAGLAFTCKLKSPVPFLGREALEQQRAAGLRRRLVCFTMEDK-VPMFGLEaIWRNGQVVGHVRRADFGFAIDKTIA 866
Cdd:PRK00389 245 ITPLEAGLGWTVKLEEKRDFIGREALEAQKEAGVERKLVGLELEERgIPRHGYP-VLADGEEIGEVTSGTFSPTLGKSIA 323

                        330
                 ....*....|....*
gi 187950339 867 YGYIHDPSGGPVSLD 881
Cdd:PRK00389 324 LAYVPAGVGDEVEVE 338
FAO_M pfam16350
FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent ...
 430-485 2.85e-21

FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent oxidoreductases: Sarcosine dehydrogenase, Dimethylglycine dehydrogenase and Dimethylglycine dehydrogenase. It is situated between the DAO domain (pfam01266) and the GCV_T domain (pfam01571).


Pssm-ID: 465100  Cd Length: 56  Bit Score: 87.89  E-value: 2.85e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 187950339  430 HGRPEKDMHGYDIRRFHHsLTDHPRWIRERSHESYAKNYSVVFPHDEPLAGRNMRR 485
Cdd:pfam16350   1 DGEPPIDLWECDIRRFGP-HQNNREYLRERVAENYGEVYDIHHPNEEREAGRPLRT 55
glpA PRK11101
anaerobic glycerol-3-phosphate dehydrogenase subunit A;
64-286 1.88e-16

anaerobic glycerol-3-phosphate dehydrogenase subunit A;


Pssm-ID: 236847 [Multi-domain]  Cd Length: 546  Bit Score: 83.53  E-value: 1.88e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  64 PSTANVVVIGGGSLGCQTLYHLAKLGMSgAVLLERERLTSGTTWHTAGLL-----WQLRPSDVEVELLAHTR--RVVSRE 136
Cdd:PRK11101   4 SQETDVIIIGGGATGAGIARDCALRGLR-CILVERHDIATGATGRNHGLLhsgarYAVTDAESARECISENQilKRIARH 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 137 LEEETGlhtgwiqngGLFIASNRQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPLMNvDDLYGTLYVPhDGTMDPAGT 216
Cdd:PRK11101  83 CVEPTD---------GLFITLPEDDLAFQATFIRACEEAGIEAEAIDPQQALILEPAVN-PALIGAVKVP-DGTVDPFRL 151

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 187950339 217 CTTLARAASARGAQVIENCPVTG-IRVWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKV 286
Cdd:PRK11101 152 TAANMLDAKEHGAQILTYHEVTGlIREGDTVCGVRVRDHLTGETQEIHAPVVVNAAGIWGQHIAEYADLRI 222
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 68-445 6.76e-13

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 71.40  E-value: 6.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339   68 NVVVIGGGSLGCQTLYHLAKLGMSgAVLLERERL--TSGTTWHTAGLLWQLRPSDVEVELLAHTRRVVSrELEEETG--L 143
Cdd:TIGR01377   2 DVIVVGAGIMGCFAAYHLAKHGKK-TLLLEQFDLphSRGSSHGQSRIIRKAYPEDFYTPMMLECYQLWA-QLEKEAGtkL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  144 HTgwiQNGGLFIASNRQRldEYKRLMSLGKAYGVESHVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARA 223
Cdd:TIGR01377  80 HR---QTGLLLLGPKENQ--FLKTIQATLSRHGLEHELLSSKQLKQRFPNIRVPRNEVGLLDPNGGVLYAEKALRALQEL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  224 ASARGAQVIENCPVTGIRVWTDdfgvrrVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTERIEG 303
Cdd:TIGR01377 155 AEAHGATVRDGTKVVEIEPTEL------LVTVKTTKGSYQANKLVVTAGAWTSKLLSPLGIEIPLQPLRINVCYWREKEP 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  304 -----IQNMPNVRDHDASVYL----RLQGDALSV----GGYEANP--IFWEevsdkfaFGLFDLDWEVFTQHIEgaiNRV 368
Cdd:TIGR01377 229 gsygvSQAFPCFLVLGLNPHIyglpSFEYPGLMKvyyhHGQQIDPdeRDCP-------FGADIEDVQILRKFVR---DHL 298

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 187950339  369 PVLEKTGIKSTVCgPESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRF 445
Cdd:TIGR01377 299 PGLNGEPKKGEVC-MYTNTPDEHFVIDLHPKYDNVVIGAGFSGHGFKLAPVVGKILAELAMKLKPSYDLAIFSLNRF 374
 
Name Accession Description Interval E-value
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 480-916 1.07e-104

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 329.35  E-value: 1.07e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 480 GRNMRRDPLHEELLGQGCVFQERHGWERPGWFHprgpapvleydyygaygsrahedyayrrlladeytfafpphhDTIKK 559
Cdd:COG0404    1 FRPLRRTPLHDRHVALGAKFVDFGGWEMPVQYP------------------------------------------GGVIA 38

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 560 ECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGSTVYTCMLNHRGGTESDLTVSRLAPshqasplapa 638
Cdd:COG0404   39 EHLAVREAVGLFDVSHMGKIEVTGPDAAAFLDRLVTNDVSKlKPGRARYTLMLNEDGGIIDDLTVYRLGE---------- 108

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 639 fegDGYYLAMGGAVAQHNWSHITTVLQDQKSqCQLIDSSEDLGMISIQGPASRAILQEVLDADLSneAFPFSTHKLLRAA 718
Cdd:COG0404  109 ---DRFLLVVNAANAAKDLAWLEEHLPPDFD-VTITDVTDDWALLAVQGPKAREVLAKLTDADLS--ALPFMSFREGTVA 182

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 719 GHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAGAKHGLINAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFT 798
Cdd:COG0404  183 GVPVRVSRTGYTGEDGFEIYVPAEDAEALWDALLEAGEEFGVKPCGLGARDTLRLEAGYPLYGHELDETTTPLEAGLGWA 262

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 799 CKLKSPvPFLGREALEQQRAAGLRRRLVCFTMEDKVPMFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYIHDpsggpv 878
Cdd:COG0404  263 VKLDKG-DFIGKEALLRQKEEGPRRKLVGLELDGRGVPRAGAPVLADGEVVGEVTSGTFSPTLGKSIALAYVPA------ 335

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 187950339 879 slDFVKSGD-YALERMGVTYGAQAHLKSPFDPNNKRVKG 916
Cdd:COG0404  336 --GLARPGTeLEVEIRGKRVPAEVVKPPFYDPEGERLRG 372
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
66-444 1.79e-84

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 275.63  E-value: 1.79e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  66 TANVVVIGGGSLGCQTLYHLAKLGMSgAVLLERERLTSGTTWHTAGLLWQLRPSDVEVELLAHTRRVVS--RELEEETGL 143
Cdd:COG0665    2 TADVVVIGGGIAGLSTAYHLARRGLD-VTVLERGRPGSGASGRNAGQLRPGLAALADRALVRLAREALDlwRELAAELGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 144 HTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARA 223
Cdd:COG0665   81 DCDFRRTGVLYLARTEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLYDPDDGHVDPAKLVRALARA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 224 ASARGAQVIENCPVTGIRVwTDDfgvrRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTERIEG 303
Cdd:COG0665  161 ARAAGVRIREGTPVTGLER-EGG----RVTGVRTERGTVRADAVVLAAGAWSARLLPMLGLRLPLRPVRGYVLVTEPLPD 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 304 IQNMPNVRDHDasVYLRLQGD-ALSVGGyeanpifweevSDKFAFGLFDLDWEVFTQHIEGAINRVPVLEKTGIKSTVCG 382
Cdd:COG0665  236 LPLRPVLDDTG--VYLRPTADgRLLVGG-----------TAEPAGFDRAPTPERLEALLRRLRRLFPALADAEIVRAWAG 302

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 187950339 383 PESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRR 444
Cdd:COG0665  303 LRPMTPDGLPIIGRLPGAPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPDR 364
GCV_T pfam01571
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, ...
 489-798 6.42e-67

Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 460255  Cd Length: 254  Bit Score: 224.01  E-value: 6.42e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  489 HEELLGQGCVFQERHGWERPGWFHPRGpapvleydyygaygsrahedyayrrlladeytfafpphhdtIKKECLACRGAA 568
Cdd:pfam01571   1 YDRHVALGAKFVEFAGWEMPVQYGSNG-----------------------------------------ILAEHRAVREAA 39

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  569 AVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGSTVYTCMLNHRGGTESDLTVSRLAPSHqasplapafegdgYYLA 647
Cdd:pfam01571  40 GLFDVSHMGKIEVSGPDAAAFLQRLTTNDVSKlKPGRATYTLMLNERGGVIDDLTVYRLGDDH-------------FLLV 106

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  648 MGGAVAQHNWSHITTVLQdqKSQCQLIDSSEDLGMISIQGPASRAILQEVLDADLsNEAFPFSTHKLLRAAGHLVRAMRL 727
Cdd:pfam01571 107 VNAANREKDLAWLRKHAE--KLDVVVVDVTDDYALLALQGPKAREVLEKLTDGDL-LEALPFFSFREIEIGGVPVRVSRT 183

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 187950339  728 SFVGELGWELHIPKASCVPVYRAVMAAGAKHGLINAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFT 798
Cdd:pfam01571 184 GYTGEDGFEIYVPAEDAVELWEALLEAGAELGLRPAGLGARDSLRLEAGLPLYGHDLDEETTPLEAGLGWA 254
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 69-427 7.90e-60

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 207.64  E-value: 7.90e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339   69 VVVIGGGSLGCQTLYHLAKLGMSgAVLLERE-RLTSGTTWHTAGLLWQLR---PSDVEVELLAHTRRVVsRELEEETGLH 144
Cdd:pfam01266   2 VVVIGGGIVGLSTAYELARRGLS-VTLLERGdDPGSGASGRNAGLIHPGLrylEPSELARLALEALDLW-EELEEELGID 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  145 TGWIQNGGLFIASNrQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPLmnVDDLYGTLYVPHDGTMDPAGTCTTLARAA 224
Cdd:pfam01266  80 CGFRRCGVLVLARD-EEEEALEKLLAALRRLGVPAELLDAEELRELEPL--LPGLRGGLFYPDGGHVDPARLLRALARAA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  225 SARGAQVIENCPVTGIRVWTDDFGVRrvagvetQHGSIQtpCVVNCAGVWASAVgRMAGVKVPLVAMHHAYVVTERIEGI 304
Cdd:pfam01266 157 EALGVRIIEGTEVTGIEEEGGVWGVV-------TTGEAD--AVVNAAGAWADLL-ALPGLRLPVRPVRGQVLVLEPLPEA 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  305 QN---MPNVRDHDASVYLRLQGD-ALSVGGYEanpifweevsDKFAFGLFDLDWEVFTQHIEGAINRVPVLEKtgIKSTV 380
Cdd:pfam01266 227 LLilpVPITVDPGRGVYLRPRADgRLLLGGTD----------EEDGFDDPTPDPEEIEELLEAARRLFPALAD--IERAW 294

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 187950339  381 CGPESfTPDHKPLMGEaPELRGFFLGCGFNSAGMMLGGGCGQELAHW 427
Cdd:pfam01266 295 AGLRP-LPDGLPIIGR-PGSPGLYLATGHGGHGLTLAPGIGKLLAEL 339
gcvT PRK00389
glycine cleavage system aminomethyltransferase GcvT;
551-881 4.56e-50

glycine cleavage system aminomethyltransferase GcvT;


Pssm-ID: 234742 [Multi-domain]  Cd Length: 359  Bit Score: 180.70  E-value: 4.56e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 551 PPHHDTIKKECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGSTVYTCMLNHRGGTESDLTVSRLAPs 629
Cdd:PRK00389  27 PVQYGSIIEEHHAVRTDAGLFDVSHMGEVDVTGPDALAFLQYLLANDVSKlKPGKAQYTCMLNEDGGVIDDLIVYKLSE- 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 630 hqasplapafegDGYYLAMGGAVAQHNWSHITTVLQDQKsqCQLIDSSEDLGMISIQGPASRAILQEVLDADLSnEAFPF 709
Cdd:PRK00389 106 ------------DEYLLVVNAANREKDLAWIKSHAAGFG--VEVTDRSDDLAMIAVQGPKAREKLQKLTDADLS-ELKPF 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 710 STHKLLRAAGHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAGAKH-GLInagyrAIDSLSIEKGYR-HWHaDLRPD 787
Cdd:PRK00389 171 FGAQGAEVGGGDVLVARTGYTGEDGFEIYLPAEDAEALWDALLEAGVKPcGLG-----ARDTLRLEAGMPlYGQ-DMDET 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 788 DSPLEAGLAFTCKLKSPVPFLGREALEQQRAAGLRRRLVCFTMEDK-VPMFGLEaIWRNGQVVGHVRRADFGFAIDKTIA 866
Cdd:PRK00389 245 ITPLEAGLGWTVKLEEKRDFIGREALEAQKEAGVERKLVGLELEERgIPRHGYP-VLADGEEIGEVTSGTFSPTLGKSIA 323

                        330
                 ....*....|....*
gi 187950339 867 YGYIHDPSGGPVSLD 881
Cdd:PRK00389 324 LAYVPAGVGDEVEVE 338
PLN02319 PLN02319
aminomethyltransferase
 555-870 2.86e-25

aminomethyltransferase


Pssm-ID: 177953 [Multi-domain]  Cd Length: 404  Bit Score: 109.43  E-value: 2.86e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 555 DTIKKECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADV-SRPPGSTVYTCMLNHRGGTESDLTVSRLapshqas 633
Cdd:PLN02319  62 DSIMDSTLNCRQNGSLFDVSHMCGLSLKGKDAIPFLETLVVADIaGLKDGTGTLSVFTNEKGGIIDDTVITKV------- 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 634 plapafEGDGYYLAMGGAVAQHNWSHITTVLQDQKSQCQliDSSE----DLGMISIQGPASRAILQEVLDADLSneAFPF 709
Cdd:PLN02319 135 ------TDDHIYLVVNAGCRDKDLAHIEEHMKAFKAKGG--DVSWhvhdERSLLALQGPLAAPVLQHLTKEDLS--KMYF 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 710 STHKLLRAAGHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAagAKHGLIN-AGYRAIDSLSIEKGYRHWHADLRPDD 788
Cdd:PLN02319 205 GDFRITDINGADCFLTRTGYTGEDGFEISVPSEHAVDLAKALLE--KSEGKVRlTGLGARDSLRLEAGLCLYGNDLEEHI 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 789 SPLEAGLAFTC--KLKSPVPFLGREALEQQRAAGLRRRLVCFTMEDKVPMFGLEAIWRNGQVVGHVRRADFGFAIDKTIA 866
Cdd:PLN02319 283 TPVEAGLAWTIgkRRRAEGGFLGADVILKQLKEGVSRRRVGFISSGAPARSHSEILDESGEKIGEVTSGGFSPCLKKNIA 362


                 ....
gi 187950339 867 YGYI 870
Cdd:PLN02319 363 MGYV 366
FAO_M pfam16350
FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent ...
 430-485 2.85e-21

FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent oxidoreductases: Sarcosine dehydrogenase, Dimethylglycine dehydrogenase and Dimethylglycine dehydrogenase. It is situated between the DAO domain (pfam01266) and the GCV_T domain (pfam01571).


Pssm-ID: 465100  Cd Length: 56  Bit Score: 87.89  E-value: 2.85e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 187950339  430 HGRPEKDMHGYDIRRFHHsLTDHPRWIRERSHESYAKNYSVVFPHDEPLAGRNMRR 485
Cdd:pfam16350   1 DGEPPIDLWECDIRRFGP-HQNNREYLRERVAENYGEVYDIHHPNEEREAGRPLRT 55
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
69-284 4.74e-19

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 90.59  E-value: 4.74e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  69 VVVIGGGSLGCQTLYHLAKLgmSGA--VLLERE-RLTSGTTWHTAGLLwqlrpsdvevellaHT-----------RRVVS 134
Cdd:COG0579    7 VVIIGAGIVGLALARELSRY--EDLkvLVLEKEdDVAQESSGNNSGVI--------------HAglyytpgslkaRLCVE 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 135 -----RELEEETGLhtGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVES-HVLSPAETKTLYPLMNVDDLYGtLYVPHD 208
Cdd:COG0579   71 gnelfYELCRELGI--PFKRCGKLVVATGEEEVAFLEKLYERGKANGVPGlEILDREELRELEPLLSDEGVAA-LYSPST 147

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 187950339 209 GTMDPAGTCTTLARAASARGAQVIENCPVTGIRVWTDDFGVrrvagvETQHGSIQTPCVVNCAGVWASAVGRMAGV 284
Cdd:COG0579  148 GIVDPGALTRALAENAEANGVELLLNTEVTGIEREGDGWEV------TTNGGTIRARFVINAAGLYADRLAQMAGI 217
glpA PRK11101
anaerobic glycerol-3-phosphate dehydrogenase subunit A;
64-286 1.88e-16

anaerobic glycerol-3-phosphate dehydrogenase subunit A;


Pssm-ID: 236847 [Multi-domain]  Cd Length: 546  Bit Score: 83.53  E-value: 1.88e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  64 PSTANVVVIGGGSLGCQTLYHLAKLGMSgAVLLERERLTSGTTWHTAGLL-----WQLRPSDVEVELLAHTR--RVVSRE 136
Cdd:PRK11101   4 SQETDVIIIGGGATGAGIARDCALRGLR-CILVERHDIATGATGRNHGLLhsgarYAVTDAESARECISENQilKRIARH 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 137 LEEETGlhtgwiqngGLFIASNRQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPLMNvDDLYGTLYVPhDGTMDPAGT 216
Cdd:PRK11101  83 CVEPTD---------GLFITLPEDDLAFQATFIRACEEAGIEAEAIDPQQALILEPAVN-PALIGAVKVP-DGTVDPFRL 151

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 187950339 217 CTTLARAASARGAQVIENCPVTG-IRVWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKV 286
Cdd:PRK11101 152 TAANMLDAKEHGAQILTYHEVTGlIREGDTVCGVRVRDHLTGETQEIHAPVVVNAAGIWGQHIAEYADLRI 222
GCV_T_C pfam08669
Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage ...
 823-908 1.90e-15

Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 462554 [Multi-domain]  Cd Length: 80  Bit Score: 72.12  E-value: 1.90e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  823 RRLVCFTMED-KVPMFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYIHDpsggpvslDFVKSG-DYALERMGVTYGAQ 900
Cdd:pfam08669   1 RRLVGLELDDgDPLLRGGEPVLRDGEVVGYVTSGAYSPTLGKSIALAYVDA--------ELAKPGtEVEVEIRGKRVPAT 72


                  ....*...
gi 187950339  901 AHLKSPFD 908
Cdd:pfam08669  73 VVKLPFYD 80
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 68-445 6.76e-13

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 71.40  E-value: 6.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339   68 NVVVIGGGSLGCQTLYHLAKLGMSgAVLLERERL--TSGTTWHTAGLLWQLRPSDVEVELLAHTRRVVSrELEEETG--L 143
Cdd:TIGR01377   2 DVIVVGAGIMGCFAAYHLAKHGKK-TLLLEQFDLphSRGSSHGQSRIIRKAYPEDFYTPMMLECYQLWA-QLEKEAGtkL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  144 HTgwiQNGGLFIASNRQRldEYKRLMSLGKAYGVESHVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARA 223
Cdd:TIGR01377  80 HR---QTGLLLLGPKENQ--FLKTIQATLSRHGLEHELLSSKQLKQRFPNIRVPRNEVGLLDPNGGVLYAEKALRALQEL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  224 ASARGAQVIENCPVTGIRVWTDdfgvrrVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTERIEG 303
Cdd:TIGR01377 155 AEAHGATVRDGTKVVEIEPTEL------LVTVKTTKGSYQANKLVVTAGAWTSKLLSPLGIEIPLQPLRINVCYWREKEP 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  304 -----IQNMPNVRDHDASVYL----RLQGDALSV----GGYEANP--IFWEevsdkfaFGLFDLDWEVFTQHIEgaiNRV 368
Cdd:TIGR01377 229 gsygvSQAFPCFLVLGLNPHIyglpSFEYPGLMKvyyhHGQQIDPdeRDCP-------FGADIEDVQILRKFVR---DHL 298

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 187950339  369 PVLEKTGIKSTVCgPESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRF 445
Cdd:TIGR01377 299 PGLNGEPKKGEVC-MYTNTPDEHFVIDLHPKYDNVVIGAGFSGHGFKLAPVVGKILAELAMKLKPSYDLAIFSLNRF 374
PRK00711 PRK00711
D-amino acid dehydrogenase;
126-288 4.28e-12

D-amino acid dehydrogenase;


Pssm-ID: 234819 [Multi-domain]  Cd Length: 416  Bit Score: 69.06  E-value: 4.28e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 126 LAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYP-LMNV-DDLYGTL 203
Cdd:PRK00711 111 LAEYSRDCLKALRAETGIQYEGRQGGTLQLFRTQQQLDAAAKDIAVLEEAGVPYELLDRDELAAVEPaLAGVrHKLVGGL 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 204 YVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTGIRVWTDdfgvrRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAG 283
Cdd:PRK00711 191 RLPNDETGDCQLFTQRLAAMAEQLGVKFRFNTPVDGLLVEGG-----RITGVQTGGGVITADAYVVALGSYSTALLKPLG 265


                 ....*
gi 187950339 284 VKVPL 288
Cdd:PRK00711 266 VDIPV 270
PRK12409 PRK12409
D-amino acid dehydrogenase small subunit; Provisional
 68-286 3.73e-11

D-amino acid dehydrogenase small subunit; Provisional


Pssm-ID: 237093 [Multi-domain]  Cd Length: 410  Bit Score: 66.20  E-value: 3.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  68 NVVVIGGGSLGCQTLYHLAKLGMSGAVLlERERL----TS-----------------------GTTWHT---AGLLWQLR 117
Cdd:PRK12409   3 HIAVIGAGITGVTTAYALAQRGYQVTVF-DRHRYaameTSfanggqlsasnaevwnhwatvlkGLKWMLrkdAPLLLNPK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 118 PS----DVEVELLAHTRR------------VVSRE----LEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGV 177
Cdd:PRK12409  82 PSwhkySWLAEFLAHIPNyrantietvrlaIAARKhlfdIAEREGIDFDLERRGILHIYHDKAGFDHAKRVNALLAEGGL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 178 ESHVLSPAETKTLYPLMNvDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTGIRVWTDDFGVRRVAGVET 257
Cdd:PRK12409 162 ERRAVTPEEMRAIEPTLT-GEYYGGYYTPSDSTGDIHKFTTGLAAACARLGVQFRYGQEVTSIKTDGGGVVLTVQPSAEH 240

                        250       260
                 ....*....|....*....|....*....
gi 187950339 258 QHGSIQTPCVVNCAGVWASAVGRMAGVKV 286
Cdd:PRK12409 241 PSRTLEFDGVVVCAGVGSRALAAMLGDRV 269
PRK11728 PRK11728
L-2-hydroxyglutarate oxidase;
151-286 6.11e-11

L-2-hydroxyglutarate oxidase;


Pssm-ID: 183292 [Multi-domain]  Cd Length: 393  Bit Score: 65.23  E-value: 6.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 151 GGLFIASNRQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPlmNVDDLyGTLYVPHDGTMDPAGTCTTLARAASARGAQ 230
Cdd:PRK11728  89 GKLLVATSELELERMEALYERARANGIEVERLDAEELREREP--NIRGL-GAIFVPSTGIVDYRAVAEAMAELIQARGGE 165

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 187950339 231 VIENCPVTGIRvwTDDFGVRrvagVETQHGSIQTPCVVNCAGVWASAVGRMAGVKV 286
Cdd:PRK11728 166 IRLGAEVTALD--EHANGVV----VRTTQGEYEARTLINCAGLMSDRLAKMAGLEP 215
solA PRK11259
N-methyl-L-tryptophan oxidase;
69-276 1.39e-10

N-methyl-L-tryptophan oxidase;


Pssm-ID: 236887 [Multi-domain]  Cd Length: 376  Bit Score: 64.09  E-value: 1.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  69 VVVIGGGSLGCQTLYHLAKLGMSgaVL-LER-------------ERLTsgttwhtagllwqlR------PSDVEVELLAH 128
Cdd:PRK11259   6 VIVIGLGSMGSAAGYYLARRGLR--VLgLDRfmpphqqgsshgdTRII--------------RhaygegPAYVPLVLRAQ 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 129 TrrvVSRELEEETG---LHtgwiQNGGLFIASNRQRLdeYKRLMSLGKAYGVESHVLSPAETKTLYPLMNVDDLYGTLYV 205
Cdd:PRK11259  70 E---LWRELERESGeplFV----RTGVLNLGPADSDF--LANSIRSARQHGLPHEVLDAAEIRRRFPQFRLPDGYIALFE 140

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 187950339 206 PHDGTMDPAGTCTTLARAASARGAQVIENCPVTGIRvwTDDFGVRrvagVETQHGSIQTPCVVNCAGVWAS 276
Cdd:PRK11259 141 PDGGFLRPELAIKAHLRLAREAGAELLFNEPVTAIE--ADGDGVT----VTTADGTYEAKKLVVSAGAWVK 205
GlpA COG0578
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 171-287 3.01e-10

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440343 [Multi-domain]  Cd Length: 501  Bit Score: 63.61  E-value: 3.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 171 LGKAYGVESH-VLSPAETKTLYPLMNVDDL-YGTLYvpHDGTMDPAGTCTTLARAASARGAQVIENCPVTGI-----RVW 243
Cdd:COG0578   93 LAGRKGLPRHrRLSRAEALALAPLLRPDGLrGGFEY--YDAQVDDARLVLELARTAAERGAVVLNYTRVTGLlrdggRVW 170

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 187950339 244 tddfGVRrVAGVET-QHGSIQTPCVVNCAGVWASAVGRMAGVKVP 287
Cdd:COG0578  171 ----GVT-VRDRLTgEEFTVRARVVVNATGPWVDELRALDGPKAP 210
dmdA PRK12486
dimethylsulfoniopropionate demethylase;
527-870 3.75e-08

dimethylsulfoniopropionate demethylase;


Pssm-ID: 237113 [Multi-domain]  Cd Length: 368  Bit Score: 56.30  E-value: 3.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 527 AYGSRAHEdyAYRRLLadeytfaFPPHHDTIKKECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGST 605
Cdd:PRK12486  22 AAGVKAYT--VYNHML-------LPTVFESVEDDYAHLKEHVQVWDVAVERQVEIRGPDAARLVQMLTPRDLRGmKPGQC 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 606 VYTCMLNHRGGTESDLTVSRLAPSHQASPLApafEGDGYYLAMGGAVAqhnwsHITTVLQDQKsqcqlidsseDLGMISI 685
Cdd:PRK12486  93 YYVPIVDETGGMLNDPVALKLAEDRWWISIA---DSDLLLWVKGLANG-----RKLDVLVVEP----------DVSPLAV 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 686 QGPASRAILQEVLDADLSN------EAFPFSTHKLLRAaghlvramRLSFVGELGWELHIPKA-SCVPVYRAVMAAGAKH 758
Cdd:PRK12486 155 QGPKADALMARVFGEAIRDlrffrfGYFDFEGTDLVIA--------RSGYSKQGGFEIYVEGSdLGMPLWDALFEAGKDL 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 759 GLINAGYRAIDSlsIEKGYRHWHADLRPDDSPLEAGLAFTCKLKSPVPFLGREALEQQRAAGLRRRLVCFTME-DKVPMF 837
Cdd:PRK12486 227 NVRAGCPNLIER--IEGGLLSYGNDMTRDNTPHECGLGRFCNTQTDIGCIGKDALLRVAKEGPQKQIRGIKIGgERIPPC 304

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 187950339 838 GleAIWR---NGQVVGHVRRADFGFAIDKTIAYGYI 870
Cdd:PRK12486 305 D--RAWPllaGDNRVGQVTSAAYSPDFQTNVAIGMV 338
PLN02464 PLN02464
glycerol-3-phosphate dehydrogenase
 1-287 4.55e-04

glycerol-3-phosphate dehydrogenase


Pssm-ID: 215257 [Multi-domain]  Cd Length: 627  Bit Score: 44.00  E-value: 4.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339   1 MASLSRALRVAAA-----------HPRQSPTRGMGPCNLSSAAGPTAEKSVPYQRTlkegQGTSVVAQGPSRPLpstaNV 69
Cdd:PLN02464   3 LARLRRLAAGAAAtaaggavylspQPASSDKGGGPALDSLRDRIADPNASVPSRSA----QESALIGATAAEPL----DV 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339  70 VVIGGGSLGCQTLYHLAKLGMSGAvLLERERLTSGTTWHTAGLLWQ-LRPSDVEV-ELLAHTRRVVSRELEEETGLhtgw 147
Cdd:PLN02464  75 LVVGGGATGAGVALDAATRGLRVG-LVEREDFSSGTSSRSTKLIHGgVRYLEKAVfQLDYGQLKLVFHALEERKQL---- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 148 IQNG-----GLFIASNRQRLDEYKRLMSLGKAY----GVESHVLS----PAETKTLYPLMNVDDLYGTL---YVPHDGTM 211
Cdd:PLN02464 150 IENAphlchALPIMTPCYDWFEVPYYWAGLKAYdlvaGPRLLHLSryysAKESLELFPTLAKKGKDGSLkgtVVYYDGQM 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187950339 212 DPAGTCTTLARAASARGAQVIENCPVTGIrvwTDDFGVRRVAGVETQHG------SIQTPCVVNCAGVWASAVGRMAGVK 285
Cdd:PLN02464 230 NDSRLNVALACTAALAGAAVLNYAEVVSL---IKDESTGRIVGARVRDNltgkefDVYAKVVVNAAGPFCDEVRKMADGK 306


                 ..
gi 187950339 286 VP 287
Cdd:PLN02464 307 AK 308
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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