second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327817 245 CYYDVVLSFSSDSELVEAFGGNQNCLDEELKAHKAVISARSPFFRNLLQRRIRTGEeitDRTLRTPTRIILDESIIPKKY 324
Cdd:cd18284    1 DYGDAVLVFASDKETVESSSGKVNEPDFELRCHKAILSARSPFFRNLLQRRIRTGE---DRTLSTPTRIVLDESIIPRRY 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 146327817 325 ATVILHCMYTDVVDLS-VLHCSPSVGSLSEVQALVAGKPNMTRAEEAMELYHIALFLEFNMLAQ 387
Cdd:cd18284   78 ARVLLHAMYTDSVDLSlILRSSPSESSLSEVQAIVAGKGPETRLEEAMELYHIARFLEFDILAQ 141

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327817 245 CYYDVVLSFSSDSELVEAFGGNQNCLDEELKAHKAVISARSPFFRNLLQRRIRTGEeitDRTLRTPTRIILDESIIPKKY 324
Cdd:cd18284    1 DYGDAVLVFASDKETVESSSGKVNEPDFELRCHKAILSARSPFFRNLLQRRIRTGE---DRTLSTPTRIVLDESIIPRRY 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 146327817 325 ATVILHCMYTDVVDLS-VLHCSPSVGSLSEVQALVAGKPNMTRAEEAMELYHIALFLEFNMLAQ 387
Cdd:cd18284   78 ARVLLHAMYTDSVDLSlILRSSPSESSLSEVQAIVAGKGPETRLEEAMELYHIARFLEFDILAQ 141

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327817  137 EYKYCtDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPE--YGAEIIMDintaGIDMPMFSALLHYLYTGEFGMEDsrf 214
Cdd:pfam00651   7 QGELC-DVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESesSVSEITLD----DVSPEDFEALLEFMYTGKLISEE--- 78

                          90       100
                  ....*....|....*....|.
gi 146327817  215 qNVDILVQLSEEFGTPNSLDV 235
Cdd:pfam00651  79 -NVDDLLAAADKLQIPSLVDK 98

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 146327817   268 NCLDEELKAHKAVISARSPFFRNLLQRRIRTGEEitdrtlrtpTRIILDEsiIPKKYATVILHCMYTDVVDLS 340
Cdd:smart00225   5 VVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDK---------SEIYLDD--VSPEDFRALLNFLYTGKLDLP 66

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327817 245 CYYDVVLSFSSDSELVEAFGGNQNCLDEELKAHKAVISARSPFFRNLLQRRIRTGEeitDRTLRTPTRIILDESIIPKKY 324
Cdd:cd18284    1 DYGDAVLVFASDKETVESSSGKVNEPDFELRCHKAILSARSPFFRNLLQRRIRTGE---DRTLSTPTRIVLDESIIPRRY 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 146327817 325 ATVILHCMYTDVVDLS-VLHCSPSVGSLSEVQALVAGKPNMTRAEEAMELYHIALFLEFNMLAQ 387
Cdd:cd18284   78 ARVLLHAMYTDSVDLSlILRSSPSESSLSEVQAIVAGKGPETRLEEAMELYHIARFLEFDILAQ 141

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327817 141 CTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINtaGIDMPMFSALLHYLYTGEFGMEDSrfqNVDIL 220
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELD--DVSPEAFEALLDYIYTGELELSEE---NVEEL 75

                 ....*..
gi 146327817 221 VQLSEEF 227
Cdd:cd18186   76 LAAADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327817 128 LQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLssspeYG-------AEI-IMDINTAGidmpmFSALL 199
Cdd:cd18287    9 LSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALL-----YGgmresqqSEIeLKDTNAEA-----FKALL 78

                 ....*.
gi 146327817 200 HYLYTG 205
Cdd:cd18287   79 KYIYTG 84

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327817   143 DVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYG--AEIIMDintaGIDMPMFSALLHYLYTGEFGMEDsrfQNVDIL 220
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESdkSEIYLD----DVSPEDFRALLNFLYTGKLDLPE---ENVEEL 73

                           90
                   ....*....|
gi 146327817   221 VQLSEEFGTP 230
Cdd:smart00225  74 LELADYLQIP 83

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327817 136 YEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEiiMDINTAGIDMPMFSALLHYLYTGEFGMEDsrfQ 215
Cdd:cd18314    1 YNDSEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNL--KEVTLEDVEPEIFETVLKYMYTGQVTLSE---E 75

                         90
                 ....*....|....*
gi 146327817 216 NVDILVQLSEEFGTP 230
Cdd:cd18314   76 NVLDLLMLASKYQVP 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 146327817 271 DEELKAHKAVISARSPFFRNLLQRRIRTGEEitdrtlrtpTRIILDEsiIPKKYATVILHCMYTDVVDLSV 341
Cdd:cd18186   10 GREFPAHRAVLAARSPYFRAMFSSGMKESSS---------SEIELDD--VSPEAFEALLDYIYTGELELSE 69

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327817 140 YCtDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTA-----------GIDMPMFSALLHYLYTGEFG 208
Cdd:cd18195   18 FC-DVTLIAGDTKFRAHRSVLAASSPYFRELLSSPLPLGAAAVAAAPGAtqspervlelpGVKAGVFSDVLNFIYSSRVA 96

                 ....*
gi 146327817 209 MEDSR 213
Cdd:cd18195   97 LPGSA 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327817 140 YCtDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTAGIDMPMFSALLHYLYTGEFGMEDSRFQNV-- 217
Cdd:cd18245   14 LC-DATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIELEGISVEVMEEILDYIYTGQIKLSEDNIQDIvq 92

                 ....*
gi 146327817 218 --DIL 220
Cdd:cd18245   93 aaDLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327817 128 LQKDMADLYEYKYCTDVDLIFQETCFPV--HRAILAARCPFFKTLLSSSPEYGAE----IIMDINTAgidmpMFSALLHY 201
Cdd:cd18294    1 FAADMKSLINNPEFSDVKFLVGPERQEIfaHKCILAARCEVFRAMFLTGPQKESTqsplVLSDIEPE-----VFRAVLEF 75

                         90       100
                 ....*....|....*....|....*..
gi 146327817 202 LYTGEfgMEDSRFQNVDILVqLSEEFG 228
Cdd:cd18294   76 IYTNC--VTLSNHTVIEVLA-AAVEYG 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327817 120 LARPEARtLQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTagIDMPMFSALL 199
Cdd:cd18343    1 LKVPECR-LAEDLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEIND--VDPEVFKEMM 77

                 ....*.
gi 146327817 200 HYLYTG 205
Cdd:cd18343   78 RFIYTG 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327817 139 KYCtDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDIntAGIDMPMFSALLHYLYTGEFgmeDSRFQNVD 218
Cdd:cd18240   16 KLC-DVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKI--PGVSPEMMELIIEYAYTRTV---PITAENVE 89

                 ....*....
gi 146327817 219 ILVQLSEEF 227
Cdd:cd18240   90 ELLPAADQF 98

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 146327817 142 TDVDLIFQETCFPVHRAILAARCPFFKTLLSS-SPEYGAEIIMDINTAGIdmpmFSALLHYLYTGE 206
Cdd:cd18315    2 VDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSE----LKALLDFIYTGE 63

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327817 140 YCtDVDLIFQETCFPVHRAILAARCPFFKTLLssSPEYGAEIIMDINTAGIDMPMFSALLHYLYTGEFGMEDSRFQNV-- 217
Cdd:cd18256   20 FC-DVQLQVGMELFSVHRLVLAASSPYFAALF--AGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVEVTVSNVQELlv 96

                         90
                 ....*....|
gi 146327817 218 --DILvQLSE 225
Cdd:cd18256   97 aaDML-QLTE 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327817 123 PEARtLQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTagIDMPMFSALLHYL 202
Cdd:cd18279    1 PECR-LAEDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEIND--VDPEVFKEMMRFI 77

                 ...
gi 146327817 203 YTG 205
Cdd:cd18279   78 YTG 80

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327817 123 PEARtLQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTagIDMPMFSALLHYL 202
Cdd:cd18345    1 PECR-LSDDLGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITD--VDHEVMREMLRFI 77

                 ....
gi 146327817 203 YTGE 206
Cdd:cd18345   78 YTGK 81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327817 127 TLQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTagIDMPMFSALLHYLYTGE 206
Cdd:cd18344    9 MLTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHD--LDPQVFKEMMGFIYTGK 86

                         90
                 ....*....|....
gi 146327817 207 FGMEDSRFQNVDIL 220
Cdd:cd18344   87 APHLHSHSMACDVL 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327817 139 KYCtDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPeygAEIIMD-INTAGIDMPMFSALLHYLYTGEFGMEDSRFQNV 217
Cdd:cd18247   18 KLC-DVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDM---VESKQDeITMQGIEPSALEALINFAYSGRIAIDTSNVQSL 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327817 141 CTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGA-EIIMDINTAGIDMPMFSALLHYLYTGEFGMEDsrfQNVDI 219
Cdd:cd18307    1 FCDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATdELSITIDCDYLSPETVEQLLDYFYTGKIVISE---KNVED 77

                         90
                 ....*....|....*
gi 146327817 220 LVQLSEEFGTPNSLD 234
Cdd:cd18307   78 LLKGAKYFNIPRLKD 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327817 142 TDVDLIFQETCFPVHRAILAARCPFFKTLLSSS-PEYGAEIimdINTAGIDMPMFSALLHYLYTGEFGMEDsrfQNVDIL 220
Cdd:cd18265   24 TDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHlKESRQAV---VEIQKVSAAAMEVLLDYMYGGGLRIQE---DNVESV 97

                         90
                 ....*....|
gi 146327817 221 VQLSEEFGTP 230
Cdd:cd18265   98 LEASDLLQVS 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327817 144 VDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYG--AEIIMDintaGIDMPMFSALLHYLYTGEFGMEDSrfqNVDILV 221
Cdd:cd01165    1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESgqAEINLR----DISPEDFRALLEFLYGGKRDLDAS---NLLELL 73

                 ..
gi 146327817 222 QL 223
Cdd:cd01165   74 EA 75

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327817 137 EYKYCtDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPeyGAEIIMDINTAGIdmpmFSALLHYLYTGEFGMEDsrfQN 216
Cdd:cd18232   15 EGQYC-DATLDVGGRVFKAHWSVLACCSHFFQSLYGDGT--SGSVVLPESFAEV----FGLLLDFFYTGELALTR---EN 84

                         90
                 ....*....|....*....
gi 146327817 217 VDILVQLSEEFGTPNSLDV 235
Cdd:cd18232   85 RDRVLLAAKELRVPEAVEL 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 146327817 142 TDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEiiMDINTAGIDMPMFSALLHYLYTGE 206
Cdd:cd18268   24 TDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQ--AKVDLKGIDSDVLDQIVDYVYTGE 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 146327817 142 TDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINtaGIDMPMFSALLHYLYTGE 206
Cdd:cd18253   19 TDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEIN--GILAEAMDCFLQYVYTGK 81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 146327817 271 DEELKAHKAVISARSPFFRNLLQRRIRTGEEitdrtlrtpTRIILDEsIIPKKYaTVILHCMYTDV 336
Cdd:cd18280   23 GEKFRAHKLVLAARSPVFRSMLFGPMREENE---------GEIVIED-VEPPVF-KALLHFIYKDE 77

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327817 139 KYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIImDINTagIDMPMFSALLHYLYTGefGMEDSRFQNVD 218
Cdd:cd18351   22 KEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSNKPSAENTCI-EISY--VKYHIFQLVMQYLYCG--GTESLLIKNNE 96

                 ....*.
gi 146327817 219 ILVQLS 224
Cdd:cd18351   97 IMELLS 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 146327817 143 DVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMdinTAGIDMPMFSALLHYLYTG 205
Cdd:cd18212   25 DITLIVENVQFRAHKALLAASSEYFSMMFADEGEVGQSIYM---LEGMVAETFGALLEFIYTG 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327817 125 ARTLQK--DMADLYEYKYCTDVDLIFqetcfpVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTagIDMPMFSALLHYL 202
Cdd:cd18353    8 AESLKKefDSPETSDLKFRVDGKYIH------VHKAVLKIRCEHFRTMFQSHWNEDMKEVIEIDQ--FSYPVYRAFLEYL 79

                 ..
gi 146327817 203 YT 204
Cdd:cd18353   80 YT 81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327817 125 ARTLQKDMADLYEYKYCTDVDL--------IFQETCFPVHRAILAARCPFFKTL----LSSSPEYGAEIimdintAGIDM 192
Cdd:cd18273   10 ARALLAQLKSFYDARLLTDVTIevngpgsgPGSGRLFPCNRNVLAAASPYFKSMftggLYESKQETVTI------HDVDS 83

                         90       100
                 ....*....|....*....|....*
gi 146327817 193 PMFSALLHYLYTGEFGMEDSRFQNV 217
Cdd:cd18273   84 ESMALIIDYCYTGRVTLSEANVQRL 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 146327817 143 DVDLIFQETCFPVHRAILAARCPFFKTLLS-SSPEYGAEiimDINTAGIDMPMFSALLHYLYTGEFGMEDSRFQNV 217
Cdd:cd18261   30 DITLVAEEQKFHAHKAVLAACSDYFRAMFSlCMVESEAD---EVNLHGVTSLGLKQALDFAYTGQILLEPGVIQDV 102

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 146327817 269 CLDEELKAHKAVISARSPFFRNLLQRRIRTGEEitdrtlrtpTRIILDEsIIPKKYATViLHCMYTDVVDLS 340
Cdd:cd18314   13 VGDRKFFAHRIVLCARSPVFRSMLTGSMIESNL---------KEVTLED-VEPEIFETV-LKYMYTGQVTLS 73

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.