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Conserved domains on  [gi|21205868|gb|AAM43838|]
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T-cell activation WD repeat protein [Homo sapiens]

Protein Classification

WD40 and Utp21 domain-containing protein( domain architecture ID 11456778)

WD40 and Utp21 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Utp21 pfam04192
Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is ...
 745-947 2.06e-68

Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is essential for synthesis of 18S rRNA.


:

Pssm-ID: 461219  Cd Length: 209  Bit Score: 226.65  E-value: 2.06e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868   745 EQLNEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEPPKVPKSAPFFIPTIPGLVPRYAAP------EQNNDPQQSKVVNL 818
Cdd:pfam04192   1 DQLSEDLVTLSLLPRSRWQTLLHLDLIKQRNKPKEAPKKPEKAPFFLPTLGGLVGDFASVeaqeeeEEEEEEERSRLLKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868   819 GVLAQKSDFCLKLEEGLVNNKYDTALNLLKESGPSGIETELRSLspDCGGSIEVMQSFLKMIGMMLDRKRDFELAQAYLA 898
Cdd:pfam04192  81 GSLGFESEFTKLLREGSETGDYTPFLEYLKSLSPSAIDLEIRSL--NSGGPLEELVSFIRALTSRLKSNRDFELVQAYMA 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 21205868   899 LFLKLHLKMLPSEPV--LLEEITNLSSQVEENWTHLQSLFNQSMCILNYLK 947
Cdd:pfam04192 159 VFLKLHGDVIHSNEEeeLREALEEWKSVQEEEWERLDELVGYCSGVVGFLR 209
WD40 COG2319
WD40 repeat [General function prediction only];
220-692 4.84e-37

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.28  E-value: 4.84e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 220 ILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRT 299
Cdd:COG2319   9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 300 DGHPVmAAGSPCGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIWifdgPTGEGRLLRFRMGHS 379
Cdd:COG2319  89 DGRLL-ASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHS 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 380 APLTNIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglinkkrvkrkglqntmsVRLppitkfaaeearesdWDg 459
Cdd:COG2319 163 GAVTSVAF-SPDGKLLASGSDDGT-----------------------------------VRL---------------WD- 190

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 460 iiaCHQGKLscstwnyqkstigayflkPKELKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHK 539
Cdd:COG2319 191 ---LATGKL------------------LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL---TGHS 246

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 540 GSVRGVAV--DGlnQLTVTTGSEGLLKFWNFKNKILIHSVS-LSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVR 616
Cdd:COG2319 247 GSVRSVAFspDG--RLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21205868 617 EFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHlGIYLWS 692
Cdd:COG2319 325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTsVAFSPDGRTLASGSADG-TVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
6-405 1.39e-26

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 1.39e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868   6 GSLRKRDSQRAPEAVLCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPH 85
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868  86 VVRFSALKRRFyVTTCVGKSFHTYDVQKLSLVAVSNSVPQDICCMA--ADGRLVFAAYGN----VFSAfaRNKEIVHTFK 159
Cdd:COG2319  83 SVAFSPDGRLL-ASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAfsPDGKTLASGSADgtvrLWDL--ATGKLLRTLT 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 160 GHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEEYLQLT-FDKSVFkiSAILHPStylNKILL-GSEQGSLQLWNVK 235
Cdd:COG2319 160 GHSGAVTSVAfsPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVR--SVAFSPD---GKLLAsGSADGTVRLWDLA 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 236 SNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPVMAAGSPcGHIG 315
Cdd:COG2319 235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD-GTVR 313

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 316 LWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIWIFDGptgeGRLLRFRMGHSAPLTNIRYyGQNGQQI 395
Cdd:COG2319 314 LWDLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT----GELLRTLTGHTGAVTSVAF-SPDGRTL 387

                       410
                ....*....|
gi 21205868 396 LSASQDGTLQ 405
Cdd:COG2319 388 ASGSADGTVR 397
 
Name Accession Description Interval E-value
Utp21 pfam04192
Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is ...
 745-947 2.06e-68

Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is essential for synthesis of 18S rRNA.


Pssm-ID: 461219  Cd Length: 209  Bit Score: 226.65  E-value: 2.06e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868   745 EQLNEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEPPKVPKSAPFFIPTIPGLVPRYAAP------EQNNDPQQSKVVNL 818
Cdd:pfam04192   1 DQLSEDLVTLSLLPRSRWQTLLHLDLIKQRNKPKEAPKKPEKAPFFLPTLGGLVGDFASVeaqeeeEEEEEEERSRLLKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868   819 GVLAQKSDFCLKLEEGLVNNKYDTALNLLKESGPSGIETELRSLspDCGGSIEVMQSFLKMIGMMLDRKRDFELAQAYLA 898
Cdd:pfam04192  81 GSLGFESEFTKLLREGSETGDYTPFLEYLKSLSPSAIDLEIRSL--NSGGPLEELVSFIRALTSRLKSNRDFELVQAYMA 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 21205868   899 LFLKLHLKMLPSEPV--LLEEITNLSSQVEENWTHLQSLFNQSMCILNYLK 947
Cdd:pfam04192 159 VFLKLHGDVIHSNEEeeLREALEEWKSVQEEEWERLDELVGYCSGVVGFLR 209
WD40 COG2319
WD40 repeat [General function prediction only];
220-692 4.84e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.28  E-value: 4.84e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 220 ILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRT 299
Cdd:COG2319   9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 300 DGHPVmAAGSPCGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIWifdgPTGEGRLLRFRMGHS 379
Cdd:COG2319  89 DGRLL-ASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHS 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 380 APLTNIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglinkkrvkrkglqntmsVRLppitkfaaeearesdWDg 459
Cdd:COG2319 163 GAVTSVAF-SPDGKLLASGSDDGT-----------------------------------VRL---------------WD- 190

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 460 iiaCHQGKLscstwnyqkstigayflkPKELKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHK 539
Cdd:COG2319 191 ---LATGKL------------------LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL---TGHS 246

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 540 GSVRGVAV--DGlnQLTVTTGSEGLLKFWNFKNKILIHSVS-LSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVR 616
Cdd:COG2319 247 GSVRSVAFspDG--RLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21205868 617 EFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHlGIYLWS 692
Cdd:COG2319 325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTsVAFSPDGRTLASGSADG-TVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 332-650 4.57e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.98  E-value: 4.57e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 332 HSTAIAGLTFLHREPLLVTNGADNALRIWIFDGptgeGRLLRFRMGHSAPLTNIRYYGqNGQQILSASQDGTLQSFSTVH 411
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET----GELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 412 EKFNKSL-GHglinKKRVkrkglqntMSVRLPPITKFAAEeareSDWDGIIAChqgklscstWNyqksTIGAYFLKPKEL 490
Cdd:cd00200  83 GECVRTLtGH----TSYV--------SSVAFSPDGRILSS----SSRDKTIKV---------WD----VETGKCLTTLRG 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 491 KKDDITAtaVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKN 570
Cdd:cd00200 134 HTDWVNS--VAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 571 KILIHSvsLSSSPNI---MLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIR 647
Cdd:cd00200 209 GKCLGT--LRGHENGvnsVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIR 286


                ...
gi 21205868 648 TWD 650
Cdd:cd00200 287 IWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
6-405 1.39e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 1.39e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868   6 GSLRKRDSQRAPEAVLCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPH 85
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868  86 VVRFSALKRRFyVTTCVGKSFHTYDVQKLSLVAVSNSVPQDICCMA--ADGRLVFAAYGN----VFSAfaRNKEIVHTFK 159
Cdd:COG2319  83 SVAFSPDGRLL-ASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAfsPDGKTLASGSADgtvrLWDL--ATGKLLRTLT 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 160 GHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEEYLQLT-FDKSVFkiSAILHPStylNKILL-GSEQGSLQLWNVK 235
Cdd:COG2319 160 GHSGAVTSVAfsPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVR--SVAFSPD---GKLLAsGSADGTVRLWDLA 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 236 SNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPVMAAGSPcGHIG 315
Cdd:COG2319 235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD-GTVR 313

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 316 LWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIWIFDGptgeGRLLRFRMGHSAPLTNIRYyGQNGQQI 395
Cdd:COG2319 314 LWDLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT----GELLRTLTGHTGAVTSVAF-SPDGRTL 387

                       410
                ....*....|
gi 21205868 396 LSASQDGTLQ 405
Cdd:COG2319 388 ASGSADGTVR 397
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 611-650 9.86e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 9.86e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 21205868    611 TRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWD 650
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
612-650 2.17e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.50  E-value: 2.17e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 21205868   612 RKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWD 650
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 149-273 9.80e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.65  E-value: 9.80e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 149 ARNKEIVHTFKGHKAEIHFLQPFGD--HIISVDTDGILIIWHIYSEEEYLQLT-FDKSVFkiSAILHPSTYLnkILLGSE 225
Cdd:cd00200 164 LRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVN--SVAFSPDGYL--LASGSE 239

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 21205868 226 QGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVII 273
Cdd:cd00200 240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 573-681 7.44e-05

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 45.80  E-value: 7.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868   573 LIHSVSLSSSPNIMLLHRDSGILGLA-LDDFSISVLDIETRKIVrefsghqGQIN------DMAFSPDGRWLISAAMDCS 645
Cdd:TIGR03866  75 VLHTLPSGPDPEQFALHPNGKILYIAnEDDALVTVIDIETRKVL-------AQIDvgvepeGMAVSPDGKIVVNTSETTN 147

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 21205868   646 IRTW-DLPSGCLIDCFLLDSAPLNVSMSPTGDFLATS 681
Cdd:TIGR03866 148 MAHWiDTATYEIVDNTLVDARPRFAEFTADGKELWVS 184
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 151-188 3.64e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 3.64e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 21205868    151 NKEIVHTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWH 188
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAfsPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
Utp21 pfam04192
Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is ...
 745-947 2.06e-68

Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is essential for synthesis of 18S rRNA.


Pssm-ID: 461219  Cd Length: 209  Bit Score: 226.65  E-value: 2.06e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868   745 EQLNEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEPPKVPKSAPFFIPTIPGLVPRYAAP------EQNNDPQQSKVVNL 818
Cdd:pfam04192   1 DQLSEDLVTLSLLPRSRWQTLLHLDLIKQRNKPKEAPKKPEKAPFFLPTLGGLVGDFASVeaqeeeEEEEEEERSRLLKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868   819 GVLAQKSDFCLKLEEGLVNNKYDTALNLLKESGPSGIETELRSLspDCGGSIEVMQSFLKMIGMMLDRKRDFELAQAYLA 898
Cdd:pfam04192  81 GSLGFESEFTKLLREGSETGDYTPFLEYLKSLSPSAIDLEIRSL--NSGGPLEELVSFIRALTSRLKSNRDFELVQAYMA 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 21205868   899 LFLKLHLKMLPSEPV--LLEEITNLSSQVEENWTHLQSLFNQSMCILNYLK 947
Cdd:pfam04192 159 VFLKLHGDVIHSNEEeeLREALEEWKSVQEEEWERLDELVGYCSGVVGFLR 209
WD40 COG2319
WD40 repeat [General function prediction only];
220-692 4.84e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.28  E-value: 4.84e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 220 ILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRT 299
Cdd:COG2319   9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 300 DGHPVmAAGSPCGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIWifdgPTGEGRLLRFRMGHS 379
Cdd:COG2319  89 DGRLL-ASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHS 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 380 APLTNIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglinkkrvkrkglqntmsVRLppitkfaaeearesdWDg 459
Cdd:COG2319 163 GAVTSVAF-SPDGKLLASGSDDGT-----------------------------------VRL---------------WD- 190

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 460 iiaCHQGKLscstwnyqkstigayflkPKELKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHK 539
Cdd:COG2319 191 ---LATGKL------------------LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL---TGHS 246

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 540 GSVRGVAV--DGlnQLTVTTGSEGLLKFWNFKNKILIHSVS-LSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVR 616
Cdd:COG2319 247 GSVRSVAFspDG--RLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21205868 617 EFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHlGIYLWS 692
Cdd:COG2319 325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTsVAFSPDGRTLASGSADG-TVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
220-653 2.81e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.97  E-value: 2.81e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 220 ILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRT 299
Cdd:COG2319  51 LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 300 DGHPVMAAGSPcGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIWifDGPTGegRLLRFRMGHS 379
Cdd:COG2319 131 DGKTLASGSAD-GTVRLWDLATGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVRLW--DLATG--KLLRTLTGHT 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 380 APLTNIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglinkkrvkrkglqntmsVRLppitkfaaeearesdWDg 459
Cdd:COG2319 205 GAVRSVAF-SPDGKLLASGSADGT-----------------------------------VRL---------------WD- 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 460 iiaCHQGKLscstwnyqkstigayflkPKELKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGkdqAHK 539
Cdd:COG2319 233 ---LATGKL------------------LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT---GHS 288

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 540 GSVRGVAV--DGlnQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSPNIML-LHRDSGILGLALDDFSISVLDIETRKIVR 616
Cdd:COG2319 289 GGVNSVAFspDG--KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVaFSPDGKTLASGSDDGTVRLWDLATGELLR 366

                       410       420       430
                ....*....|....*....|....*....|....*..
gi 21205868 617 EFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPS 653
Cdd:COG2319 367 TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 332-650 4.57e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.98  E-value: 4.57e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 332 HSTAIAGLTFLHREPLLVTNGADNALRIWIFDGptgeGRLLRFRMGHSAPLTNIRYYGqNGQQILSASQDGTLQSFSTVH 411
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET----GELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 412 EKFNKSL-GHglinKKRVkrkglqntMSVRLPPITKFAAEeareSDWDGIIAChqgklscstWNyqksTIGAYFLKPKEL 490
Cdd:cd00200  83 GECVRTLtGH----TSYV--------SSVAFSPDGRILSS----SSRDKTIKV---------WD----VETGKCLTTLRG 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 491 KKDDITAtaVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKN 570
Cdd:cd00200 134 HTDWVNS--VAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 571 KILIHSvsLSSSPNI---MLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIR 647
Cdd:cd00200 209 GKCLGT--LRGHENGvnsVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIR 286


                ...
gi 21205868 648 TWD 650
Cdd:cd00200 287 IWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
6-405 1.39e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 1.39e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868   6 GSLRKRDSQRAPEAVLCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPH 85
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868  86 VVRFSALKRRFyVTTCVGKSFHTYDVQKLSLVAVSNSVPQDICCMA--ADGRLVFAAYGN----VFSAfaRNKEIVHTFK 159
Cdd:COG2319  83 SVAFSPDGRLL-ASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAfsPDGKTLASGSADgtvrLWDL--ATGKLLRTLT 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 160 GHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEEYLQLT-FDKSVFkiSAILHPStylNKILL-GSEQGSLQLWNVK 235
Cdd:COG2319 160 GHSGAVTSVAfsPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVR--SVAFSPD---GKLLAsGSADGTVRLWDLA 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 236 SNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPVMAAGSPcGHIG 315
Cdd:COG2319 235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD-GTVR 313

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 316 LWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIWIFDGptgeGRLLRFRMGHSAPLTNIRYyGQNGQQI 395
Cdd:COG2319 314 LWDLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT----GELLRTLTGHTGAVTSVAF-SPDGRTL 387

                       410
                ....*....|
gi 21205868 396 LSASQDGTLQ 405
Cdd:COG2319 388 ASGSADGTVR 397
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 155-420 2.20e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.04  E-value: 2.20e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 155 VHTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEEYLQLT-FDKSVFKISAILHpstyLNKILLGSEQGSLQL 231
Cdd:cd00200   2 RRTLKGHTGGVTCVAfsPDGKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASAD----GTYLASGSSDKTIRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 232 WNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHpVMAAGSPC 311
Cdd:cd00200  78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASSSQD 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 312 GHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIWIFDgptgEGRLLRFRMGHSAPLTNIRYyGQN 391
Cdd:cd00200 157 GTIKLWDLRTGKCVATLT-GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS----TGKCLGTLRGHENGVNSVAF-SPD 230

                       250       260       270
                ....*....|....*....|....*....|
gi 21205868 392 GQQILSASQDGTLQSFSTVHEKFNKSL-GH 420
Cdd:cd00200 231 GYLLASGSEDGTIRVWDLRTGECVQTLsGH 260
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 127-404 5.74e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.02  E-value: 5.74e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 127 ICCMA--ADGRLVFAAYGN----VFSAFarNKEIVHTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEEYLQL 198
Cdd:cd00200  12 VTCVAfsPDGKLLATGSGDgtikVWDLE--TGELLRTLKGHTGPVRDVAasADGTYLASGSSDKTIRLWDLETGECVRTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 199 T-FDKSVFKISaiLHPSTYLnkILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIK 277
Cdd:cd00200  90 TgHTSYVSSVA--FSPDGRI--LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 278 FNETLMKFRQDWGPITSISFRTDGHPVMAAGSPcGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNAL 357
Cdd:cd00200 166 TGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSD-GTIKLWDLSTGKCLGTLR-GHENGVNSVAFSPDGYLLASGSEDGTI 243

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 21205868 358 RIWifDGPTGEgRLLRFRmGHSAPLTNIRYYGqNGQQILSASQDGTL 404
Cdd:cd00200 244 RVW--DLRTGE-CVQTLS-GHTNSVTSLAWSP-DGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
87-360 4.98e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 4.98e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868  87 VRFSALKRRFyVTTCVGKSFHTYDVQKLSLVAVSNSVPQDICCMA--ADGRLVFAAYGN----VFSAfaRNKEIVHTFKG 160
Cdd:COG2319 126 VAFSPDGKTL-ASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAfsPDGKLLASGSDDgtvrLWDL--ATGKLLRTLTG 202

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 161 HKAEIHFLQ--PFGDHIISVDTDGILIIWHIYSEEeyLQLTFDKSVFKISAI-LHPStylNKILL-GSEQGSLQLWNVKS 236
Cdd:COG2319 203 HTGAVRSVAfsPDGKLLASGSADGTVRLWDLATGK--LLRTLTGHSGSVRSVaFSPD---GRLLAsGSADGTVRLWDLAT 277

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 237 NKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPVmAAGSPCGHIGL 316
Cdd:COG2319 278 GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTL-ASGSDDGTVRL 356

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 21205868 317 WDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIW 360
Cdd:COG2319 357 WDLATGELLRTLT-GHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 498-692 1.47e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 1.47e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 498 TAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIH-- 575
Cdd:cd00200  13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL---KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRtl 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 576 --------SVSLSSSPNIML---------------------------------LHRDSGILGLALDDFSISVLDIETRKI 614
Cdd:cd00200  90 tghtsyvsSVAFSPDGRILSsssrdktikvwdvetgkclttlrghtdwvnsvaFSPDGTFVASSSQDGTIKLWDLRTGKC 169

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21205868 615 VREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHlGIYLWS 692
Cdd:cd00200 170 VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsVAFSPDGYLLASGSEDG-TIRVWD 247
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 536-692 2.60e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 2.60e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 536 QAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILI-----HSVSLSSSpnimLLHRDSGILGLALDDFSISVLDIE 610
Cdd:cd00200   6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLrtlkgHTGPVRDV----AASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 611 TRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHLgIY 689
Cdd:cd00200  82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNsVAFSPDGTFVASSSQDGT-IK 160


                ...
gi 21205868 690 LWS 692
Cdd:cd00200 161 LWD 163
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 150-360 8.10e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.22  E-value: 8.10e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 150 RNKEIVHTFKGHKAEI---HFLQpfGDHIISVD-TDGILIIWHIysEEEYLQLTFD---KSVFKISaiLHPStylNKILL 222
Cdd:cd00200  81 ETGECVRTLTGHTSYVssvAFSP--DGRILSSSsRDKTIKVWDV--ETGKCLTTLRghtDWVNSVA--FSPD---GTFVA 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 223 GSEQ-GSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDG 301
Cdd:cd00200 152 SSSQdGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG 231

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21205868 302 HpVMAAGSPCGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIW 360
Cdd:cd00200 232 Y-LLASGSEDGTIRVWDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 615-692 5.30e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.58  E-value: 5.30e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21205868 615 VREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHLgIYLWS 692
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRdVAASADGTYLASGSSDKT-IRLWD 79
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 611-650 9.86e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 9.86e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 21205868    611 TRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWD 650
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
612-650 2.17e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.50  E-value: 2.17e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 21205868   612 RKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWD 650
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
495-678 2.79e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 55.47  E-value: 2.79e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 495 ITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGlNQLTVTTGSEGLLKFWNFKNKILI 574
Cdd:COG3391  25 VAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADG-RRLYVANSGSGRVSVIDLATGKVV 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 575 HSVSLSSSPNIMLLHRDSGILGLA-LDDFSISVLDIETRKIVREFSGHqGQINDMAFSPDGRWLISAAMDCS-----IRT 648
Cdd:COG3391 104 ATIPVGGGPRGLAVDPDGGRLYVAdSGNGRVSVIDTATGKVVATIPVG-AGPHGIAVDPDGKRLYVANSGSNtvsviVSV 182

                       170       180       190
                ....*....|....*....|....*....|
gi 21205868 649 WDLPSGCLIDCFLLDSAPLNVSMSPTGDFL 678
Cdd:COG3391 183 IDTATGKVVATIPVGGGPVGVAVSPDGRRL 212
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 149-273 9.80e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.65  E-value: 9.80e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868 149 ARNKEIVHTFKGHKAEIHFLQPFGD--HIISVDTDGILIIWHIYSEEEYLQLT-FDKSVFkiSAILHPSTYLnkILLGSE 225
Cdd:cd00200 164 LRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVN--SVAFSPDGYL--LASGSE 239

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 21205868 226 QGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVII 273
Cdd:cd00200 240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 573-681 7.44e-05

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 45.80  E-value: 7.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868   573 LIHSVSLSSSPNIMLLHRDSGILGLA-LDDFSISVLDIETRKIVrefsghqGQIN------DMAFSPDGRWLISAAMDCS 645
Cdd:TIGR03866  75 VLHTLPSGPDPEQFALHPNGKILYIAnEDDALVTVIDIETRKVL-------AQIDvgvepeGMAVSPDGKIVVNTSETTN 147

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 21205868   646 IRTW-DLPSGCLIDCFLLDSAPLNVSMSPTGDFLATS 681
Cdd:TIGR03866 148 MAHWiDTATYEIVDNTLVDARPRFAEFTADGKELWVS 184
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 257-341 8.50e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.18  E-value: 8.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21205868   257 PAVDVVAIGLMSGQVIIHNIKFNE--TLMKFRQDwGPITSISFRTDGHpVMAAGSPCGHIGLWDLEDKKLINQmRNAHST 334
Cdd:pfam12894   5 PTMDLIALATEDGELLLHRLNWQRvwTLSPDKED-LEVTSLAWRPDGK-LLAVGYSDGTVRLLDAENGKIVHH-FSAGSD 81


                  ....*..
gi 21205868   335 AIAGLTF 341
Cdd:pfam12894  82 LITCLGW 88
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 600-637 2.44e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 41.95  E-value: 2.44e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 21205868  600 DDFSISVLDIET---RKIVRefSGHQGQINDMAFSPDGRWL 637
Cdd:COG4946  408 NRGRLWVVDLASgkvRKVDT--DGYGDGISDLAWSPDSKWL 446
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 151-188 3.64e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 3.64e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 21205868    151 NKEIVHTFKGHKAEIHFLQ--PFGDHIISVDTDGILIIWH 188
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAfsPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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