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Conserved domains on  [gi|45271101|gb|AAS56933|]
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immune-associated nucleotide 4-like 1 mouse-C [Rattus norvegicus]

Protein Classification

GTPase IMAP family protein( domain architecture ID 10111261)

GTPase immunity-associated protein (IMAP) family protein may function as regulator of lymphocyte survival and homeostasis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 45-245 7.38e-99

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


:

Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 289.82  E-value: 7.38e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45271101  45 LRILLVGKSGCGKSATGNSILRRPAFESRLRGQSVTRTSQAEMGTWEGRSFLVVDTPPIFESKIQNQDMDKDIGNCYLMC 124
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKEIIRCLSLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45271101 125 APGPHVLLLVTQLGRYTVEDAMAVRMVKQIFGVGVMRYMIVLFTHKEDLADESLEEFVtHTGNLDLHRLVQECGRRYCAF 204
Cdd:cd01852  81 APGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYL-EDSCEALKRLLEKCGGRYVAF 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 45271101 205 NNKASGEEQQGQLAELMALVRRLEQEHEGSFHSNDLFVYTQ 245
Cdd:cd01852 160 NNKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAE 200
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 14-66 3.14e-03

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd03257:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 228  Bit Score: 38.26  E-value: 3.14e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45271101  14 HDLNVRRLTKG-------NINFLLSTGqETYSvedsgllrilLVGKSGCGKSATGNSILR 66
Cdd:cd03257   5 KNLSVSFPTGGgsvkaldDVSFSIKKG-ETLG----------LVGESGSGKSTLARAILG 53
 
Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 45-245 7.38e-99

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 289.82  E-value: 7.38e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45271101  45 LRILLVGKSGCGKSATGNSILRRPAFESRLRGQSVTRTSQAEMGTWEGRSFLVVDTPPIFESKIQNQDMDKDIGNCYLMC 124
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKEIIRCLSLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45271101 125 APGPHVLLLVTQLGRYTVEDAMAVRMVKQIFGVGVMRYMIVLFTHKEDLADESLEEFVtHTGNLDLHRLVQECGRRYCAF 204
Cdd:cd01852  81 APGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYL-EDSCEALKRLLEKCGGRYVAF 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 45271101 205 NNKASGEEQQGQLAELMALVRRLEQEHEGSFHSNDLFVYTQ 245
Cdd:cd01852 160 NNKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAE 200
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 45-245 6.34e-93

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 274.87  E-value: 6.34e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45271101    45 LRILLVGKSGCGKSATGNSILRRPAFESRLRGQSVTRTSQAEMGTWEGRSFLVVDTPPIFESKIQNQDMDKDIGNCYLMC 124
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVSNDFISKEIIRCLLLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45271101   125 APGPHVLLLVTQLGRYTVEDAMAVRMVKQIFGVGVMRYMIVLFTHKEDLADESLEEFVTHTGNLDLHRLVQEcgrrycaf 204
Cdd:pfam04548  81 EPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDGCPEFLKEVLRT-------- 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 45271101   205 nnkASGEEQQGQLAELMALVRRLEQEHEGSFHSNDLFVYTQ 245
Cdd:pfam04548 153 ---ADGEEKEEQVQQLLALVEAIVKENGGKPYTNDLYEKIK 190
3a0901s02IAP34 TIGR00991
GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding ...
 37-187 3.74e-09

GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 130064  Cd Length: 313  Bit Score: 56.83  E-value: 3.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45271101    37 YSVEDSGLLRILLVGKSGCGKSATGNSILRR-----PAFESR-LRGQSVTRTSQaemgtweGRSFLVVDTPPIFESKIQN 110
Cdd:TIGR00991  31 LKEEDVSSLTILVMGKGGVGKSSTVNSIIGEriatvSAFQSEgLRPMMVSRTRA-------GFTLNIIDTPGLIEGGYIN 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45271101   111 qDMDKDIGNCYLMcAPGPHVLLLVTQLGRYTVE--DAMAVRMVKQIFGVGVMRYMIVLFTHKEDLADESLE--EFVTHTG 186
Cdd:TIGR00991 104 -DQAVNIIKRFLL-GKTIDVLLYVDRLDAYRVDtlDGQVIRAITDSFGKDIWRKSLVVLTHAQFSPPDGLEynDFFSKRS 181


                  .
gi 45271101   187 N 187
Cdd:TIGR00991 182 E 182
YeeP COG3596
Predicted GTPase [General function prediction only];
45-173 1.70e-05

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 45.91  E-value: 1.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45271101  45 LRILLVGKSGCGKSATGNSILRRPAFE-SRLRGqsVTRTSQA-EMGTWEGRSFLVVDTPPIFESkiqNQDMDKDIGncYL 122
Cdd:COG3596  40 PVIALVGKTGAGKSSLINALFGAEVAEvGVGRP--CTREIQRyRLESDGLPGLVLLDTPGLGEV---NERDREYRE--LR 112

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 45271101 123 MCAPGPHVLLLVTQLGRYTveDAMAVRMVKQIFGVGVMRYMIVLFTHKEDL 173
Cdd:COG3596 113 ELLPEADLILWVVKADDRA--LATDEEFLQALRAQYPDPPVLVVLTQVDRL 161
ABC_NikE_OppD_transporters cd03257
ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter ...
 14-66 3.14e-03

ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane components (NikB and NikC), and two ATPase (NikD and NikE). The NikABCDE transporter is synthesized under anaerobic conditions to meet the increased demand for nickel resulting from hydrogenase synthesis. The molecular mechanism of nickel uptake in many bacteria and most archaea is not known. Many other members of this ABC family are also involved in the uptake of dipeptides and oligopeptides. The oligopeptide transport system (Opp) is a five-component ABC transport composed of a membrane-anchored substrate binding proteins (SRP), OppA, two transmembrane proteins, OppB and OppC, and two ATP-binding domains, OppD and OppF.


Pssm-ID: 213224 [Multi-domain]  Cd Length: 228  Bit Score: 38.26  E-value: 3.14e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45271101  14 HDLNVRRLTKG-------NINFLLSTGqETYSvedsgllrilLVGKSGCGKSATGNSILR 66
Cdd:cd03257   5 KNLSVSFPTGGgsvkaldDVSFSIKKG-ETLG----------LVGESGSGKSTLARAILG 53
 
Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 45-245 7.38e-99

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 289.82  E-value: 7.38e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45271101  45 LRILLVGKSGCGKSATGNSILRRPAFESRLRGQSVTRTSQAEMGTWEGRSFLVVDTPPIFESKIQNQDMDKDIGNCYLMC 124
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKEIIRCLSLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45271101 125 APGPHVLLLVTQLGRYTVEDAMAVRMVKQIFGVGVMRYMIVLFTHKEDLADESLEEFVtHTGNLDLHRLVQECGRRYCAF 204
Cdd:cd01852  81 APGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYL-EDSCEALKRLLEKCGGRYVAF 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 45271101 205 NNKASGEEQQGQLAELMALVRRLEQEHEGSFHSNDLFVYTQ 245
Cdd:cd01852 160 NNKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAE 200
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 45-245 6.34e-93

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 274.87  E-value: 6.34e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45271101    45 LRILLVGKSGCGKSATGNSILRRPAFESRLRGQSVTRTSQAEMGTWEGRSFLVVDTPPIFESKIQNQDMDKDIGNCYLMC 124
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVSNDFISKEIIRCLLLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45271101   125 APGPHVLLLVTQLGRYTVEDAMAVRMVKQIFGVGVMRYMIVLFTHKEDLADESLEEFVTHTGNLDLHRLVQEcgrrycaf 204
Cdd:pfam04548  81 EPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDGCPEFLKEVLRT-------- 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 45271101   205 nnkASGEEQQGQLAELMALVRRLEQEHEGSFHSNDLFVYTQ 245
Cdd:pfam04548 153 ---ADGEEKEEQVQQLLALVEAIVKENGGKPYTNDLYEKIK 190
Toc34_like cd01853
Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like ...
 29-169 3.06e-12

Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like (Translocon at the Outer-envelope membrane of Chloroplasts) family contains several Toc proteins, including Toc34, Toc33, Toc120, Toc159, Toc86, Toc125, and Toc90. The Toc complex at the outer envelope membrane of chloroplasts is a molecular machine of ~500 kDa that contains a single Toc159 protein, four Toc75 molecules, and four or five copies of Toc34. Toc64 and Toc12 are associated with the translocon, but do not appear to be part of the core complex. The Toc translocon initiates the import of nuclear-encoded preproteins from the cytosol into the organelle. Toc34 and Toc159 are both GTPases, while Toc75 is a beta-barrel integral membrane protein. Toc159 is equally distributed between a soluble cytoplasmic form and a membrane-inserted form, suggesting that assembly of the Toc complex is dynamic. Toc34 and Toc75 act sequentially to mediate docking and insertion of Toc159 resulting in assembly of the functional translocon.


Pssm-ID: 206652  Cd Length: 248  Bit Score: 65.42  E-value: 3.06e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45271101  29 LLSTGQEtysvEDSGLLRILLVGKSGCGKSATGNSILrrpafesrlrGQSVTRTS--QAE-------MGTWEGRSFLVVD 99
Cdd:cd01853  20 LEAKLKK----ELDFSLTILVLGKTGVGKSSTINSIF----------GERKVSVSafQSEtlrprevSRTVDGFKLNIID 85

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45271101 100 TPPIFESKIQNQDmDK--DIGNCYLMCAPgPHVLLLVTQLGRYTVE--DAMAVRMVKQIFGVGVMRYMIVLFTH 169
Cdd:cd01853  86 TPGLLESQDQRVN-RKilSIIKRFLKKKT-IDVVLYVDRLDMYRVDnlDVPLLRAITDSFGPSIWRNAIVVLTH 157
3a0901s02IAP34 TIGR00991
GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding ...
 37-187 3.74e-09

GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 130064  Cd Length: 313  Bit Score: 56.83  E-value: 3.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45271101    37 YSVEDSGLLRILLVGKSGCGKSATGNSILRR-----PAFESR-LRGQSVTRTSQaemgtweGRSFLVVDTPPIFESKIQN 110
Cdd:TIGR00991  31 LKEEDVSSLTILVMGKGGVGKSSTVNSIIGEriatvSAFQSEgLRPMMVSRTRA-------GFTLNIIDTPGLIEGGYIN 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45271101   111 qDMDKDIGNCYLMcAPGPHVLLLVTQLGRYTVE--DAMAVRMVKQIFGVGVMRYMIVLFTHKEDLADESLE--EFVTHTG 186
Cdd:TIGR00991 104 -DQAVNIIKRFLL-GKTIDVLLYVDRLDAYRVDtlDGQVIRAITDSFGKDIWRKSLVVLTHAQFSPPDGLEynDFFSKRS 181


                  .
gi 45271101   187 N 187
Cdd:TIGR00991 182 E 182
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 45-169 1.53e-07

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 53.03  E-value: 1.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45271101    45 LRILLVGKSGCGKSATGNSILRRPAFESRLRGQSVTRTSQAEmGTWEGRSFLVVDTPPIFESKIqNQDMDKDIGNCY--L 122
Cdd:TIGR00993 119 LNILVLGKSGVGKSATINSIFGEVKFSTDAFGMGTTSVQEIE-GLVQGVKIRVIDTPGLKSSAS-DQSKNEKILSSVkkF 196

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 45271101   123 MCAPGPHVLLLVTQLGRYT--VEDAMAVRMVKQIFGVGVMRYMIVLFTH 169
Cdd:TIGR00993 197 IKKNPPDIVLYVDRLDMQTrdSNDLPLLRTITDVLGPSIWFNAIVTLTH 245
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 48-182 4.59e-07

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 48.99  E-value: 4.59e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45271101  48 LLVGKSGCGKSATGNSILRRPAFE-SRLRGqsVTRTSQAEMGTWE--GRSFLVVDTPPIFESKiqnqdmDKDIGNCYLMC 124
Cdd:cd00882   1 VVVGRGGVGKSSLLNALLGGEVGEvSDVPG--TTRDPDVYVKELDkgKVKLVLVDTPGLDEFG------GLGREELARLL 72

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 45271101 125 APGPHVLLLVTQLGRYTVEDAMAVRMVKQIFGVGVmrYMIVLFTHKEDLADESLEEFV 182
Cdd:cd00882  73 LRGADLILLVVDSTDRESEEDAKLLILRRLRKEGI--PIILVGNKIDLLEEREVEELL 128
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 46-117 1.25e-06

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 46.46  E-value: 1.25e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45271101    46 RILLVGKSGCGKSATGNSILRRPAFESRLRGqsVTRTSQAEMGTWEGRSFLVVDTPPIFESKIQNQDMDKDI 117
Cdd:pfam01926   1 RVALVGRPNVGKSTLINALTGAKAIVSDYPG--TTRDPNEGRLELKGKQIILVDTPGLIEGASEGEGLGRAF 70
YeeP COG3596
Predicted GTPase [General function prediction only];
45-173 1.70e-05

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 45.91  E-value: 1.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45271101  45 LRILLVGKSGCGKSATGNSILRRPAFE-SRLRGqsVTRTSQA-EMGTWEGRSFLVVDTPPIFESkiqNQDMDKDIGncYL 122
Cdd:COG3596  40 PVIALVGKTGAGKSSLINALFGAEVAEvGVGRP--CTREIQRyRLESDGLPGLVLLDTPGLGEV---NERDREYRE--LR 112

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 45271101 123 MCAPGPHVLLLVTQLGRYTveDAMAVRMVKQIFGVGVMRYMIVLFTHKEDL 173
Cdd:COG3596 113 ELLPEADLILWVVKADDRA--LATDEEFLQALRAQYPDPPVLVVLTQVDRL 161
DppD COG0444
ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid ...
 49-87 4.60e-05

ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440213 [Multi-domain]  Cd Length: 320  Bit Score: 44.66  E-value: 4.60e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 45271101  49 LVGKSGCGKSATGNSILR---RPAFES---RLRGQSVTRTSQAEM 87
Cdd:COG0444  36 LVGESGSGKSTLARAILGllpPPGITSgeiLFDGEDLLKLSEKEL 80
AppF COG4608
ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; ...
 49-87 5.85e-05

ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism];


Pssm-ID: 443658 [Multi-domain]  Cd Length: 329  Bit Score: 44.34  E-value: 5.85e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 45271101  49 LVGKSGCGKSATGNSILR--RP-AFESRLRGQSVTRTSQAEM 87
Cdd:COG4608  49 LVGESGCGKSTLGRLLLRleEPtSGEILFDGQDITGLSGREL 90
YejF COG4172
ABC-type microcin C transport system, duplicated ATPase component YejF [Secondary metabolites ...
 49-87 1.27e-03

ABC-type microcin C transport system, duplicated ATPase component YejF [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443332 [Multi-domain]  Cd Length: 533  Bit Score: 40.44  E-value: 1.27e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 45271101  49 LVGKSGCGKSATGNSILR-------RPAFESRLRGQSVTRTSQAEM 87
Cdd:COG4172  41 LVGESGSGKSVTALSILRllpdpaaHPSGSILFDGQDLLGLSEREL 86
ABC_NikE_OppD_transporters cd03257
ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter ...
 14-66 3.14e-03

ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane components (NikB and NikC), and two ATPase (NikD and NikE). The NikABCDE transporter is synthesized under anaerobic conditions to meet the increased demand for nickel resulting from hydrogenase synthesis. The molecular mechanism of nickel uptake in many bacteria and most archaea is not known. Many other members of this ABC family are also involved in the uptake of dipeptides and oligopeptides. The oligopeptide transport system (Opp) is a five-component ABC transport composed of a membrane-anchored substrate binding proteins (SRP), OppA, two transmembrane proteins, OppB and OppC, and two ATP-binding domains, OppD and OppF.


Pssm-ID: 213224 [Multi-domain]  Cd Length: 228  Bit Score: 38.26  E-value: 3.14e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45271101  14 HDLNVRRLTKG-------NINFLLSTGqETYSvedsgllrilLVGKSGCGKSATGNSILR 66
Cdd:cd03257   5 KNLSVSFPTGGgsvkaldDVSFSIKKG-ETLG----------LVGESGSGKSTLARAILG 53
EngA1 cd01894
EngA1 GTPase contains the first domain of EngA; This EngA1 subfamily CD represents the first ...
 49-111 4.50e-03

EngA1 GTPase contains the first domain of EngA; This EngA1 subfamily CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Although the exact function of these proteins has not been elucidated, studies have revealed that the E. coli EngA homolog, Der, and Neisseria gonorrhoeae EngA are essential for cell viability. A recent report suggests that E. coli Der functions in ribosome assembly and stability.


Pssm-ID: 206681 [Multi-domain]  Cd Length: 157  Bit Score: 37.03  E-value: 4.50e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45271101  49 LVGKSGCGKSATGNSILRRP-AFESRLRGqsVTRTSQAEMGTWEGRSFLVVDTP------PIFESKIQNQ 111
Cdd:cd01894   2 IVGRPNVGKSTLFNRLTGRRdAIVSDTPG--VTRDRKYGEAEWGGREFILIDTGgiepddEGISKEIREQ 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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