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Conserved domains on  [gi|46981981|gb|AAT08039|]
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aging-associated protein 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hip_N cd14438
N-terminal dimerization domain of the Hsp70-interacting protein (Hip) and similar proteins; ...
 3-43 2.11e-19

N-terminal dimerization domain of the Hsp70-interacting protein (Hip) and similar proteins; The Hsc70/Hsp70-interacting protein (Hip, also p48 or suppressor of tumorigenicity ST13) functions as a regulator of the cyclic action of Hsp70. Hip forms homodimers, and this model characterizes the N-terminal dimerization domain, which may not be directly involved in its regulatory function. A central domain of Hip that contains TPR repeats binds the ATPase domain of Hsp70 and slows the release of ADP.


:

Pssm-ID: 271228  Cd Length: 41  Bit Score: 80.28  E-value: 2.11e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 46981981   3 PRKVNELRAFVKMCKQDPSVLHTEEMRFLREWVESMGGKVP 43
Cdd:cd14438   1 PEKLKELKAFVELCKQNPSILHTPELSFFKEYLESLGAKIP 41
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
128-221 3.64e-16

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 76.88  E-value: 3.64e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981 128 GELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLAL 207
Cdd:COG4785  87 GDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEK 166

                        90
                ....*....|....
gi 46981981 208 ACKLDyDEDASAML 221
Cdd:COG4785 167 ALELD-PNDPERAL 179
STI1 smart00727
Heat shock chaperonin-binding motif;
319-358 4.44e-09

Heat shock chaperonin-binding motif;


:

Pssm-ID: 128966  Cd Length: 41  Bit Score: 51.50  E-value: 4.44e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 46981981    319 DPEVLAAMQDPEVMVAFQDVAQNPANMSKY-QSNPKVMNLI 358
Cdd:smart00727   1 DPEMALRLQNPQVQSLLQDMQQNPDMLAQMlQENPQLLQLI 41
 
Name Accession Description Interval E-value
Hip_N cd14438
N-terminal dimerization domain of the Hsp70-interacting protein (Hip) and similar proteins; ...
 3-43 2.11e-19

N-terminal dimerization domain of the Hsp70-interacting protein (Hip) and similar proteins; The Hsc70/Hsp70-interacting protein (Hip, also p48 or suppressor of tumorigenicity ST13) functions as a regulator of the cyclic action of Hsp70. Hip forms homodimers, and this model characterizes the N-terminal dimerization domain, which may not be directly involved in its regulatory function. A central domain of Hip that contains TPR repeats binds the ATPase domain of Hsp70 and slows the release of ADP.


Pssm-ID: 271228  Cd Length: 41  Bit Score: 80.28  E-value: 2.11e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 46981981   3 PRKVNELRAFVKMCKQDPSVLHTEEMRFLREWVESMGGKVP 43
Cdd:cd14438   1 PEKLKELKAFVELCKQNPSILHTPELSFFKEYLESLGAKIP 41
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
128-221 3.64e-16

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 76.88  E-value: 3.64e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981 128 GELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLAL 207
Cdd:COG4785  87 GDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEK 166

                        90
                ....*....|....
gi 46981981 208 ACKLDyDEDASAML 221
Cdd:COG4785 167 ALELD-PNDPERAL 179
HipN pfam18253
Hsp70-interacting protein N N-terminal domain; This is the N-terminal domain, known as HipN, ...
 2-43 4.44e-16

Hsp70-interacting protein N N-terminal domain; This is the N-terminal domain, known as HipN, found in Hsp70-interacting protein (Hip) present in Rattus norvegicus. Hip cooperates with the chaperone Hsp70 in protein folding and prevention of aggregation and may delay substrate release by slowing ADP dissociation from Hsp70. HipN is responsible for N-terminal homo-dimerization which is necessary so that the Hip dimer can interact with Hsp70 molecules.


Pssm-ID: 408069  Cd Length: 42  Bit Score: 71.15  E-value: 4.44e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 46981981     2 DPRKVNELRAFVKMCKQDPSVLHTEEMRFLREWVESMGGKVP 43
Cdd:pfam18253   1 DPAHLSLLKQFVDLCKANPSILHLPELAFFKEFLESLGATVP 42
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 114-233 1.78e-09

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 58.64  E-value: 1.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981  114 ANDKKVAAIEALNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHR 193
Cdd:PLN03088   2 AKDLEDKAKEAFVDDDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACM 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 46981981  194 LLGHWEEAAHDLALACKLDYDEDASA-MLKEVQpraQKIAE 233
Cdd:PLN03088  82 KLEEYQTAKAALEKGASLAPGDSRFTkLIKECD---EKIAE 119
STI1 smart00727
Heat shock chaperonin-binding motif;
319-358 4.44e-09

Heat shock chaperonin-binding motif;


Pssm-ID: 128966  Cd Length: 41  Bit Score: 51.50  E-value: 4.44e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 46981981    319 DPEVLAAMQDPEVMVAFQDVAQNPANMSKY-QSNPKVMNLI 358
Cdd:smart00727   1 DPEMALRLQNPQVQSLLQDMQQNPDMLAQMlQENPQLLQLI 41
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 45-214 1.57e-08

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 56.15  E-value: 1.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981    45 ATQKAKSEENTKEEK-PDSKKVEEDLKA----DEPSSEESDLEIDKE---GVIEPDTDAPQEMGDENAEITEEMMDQAND 116
Cdd:TIGR00990 243 AESKAKEILETKPENlPSVTFVGNYLQSfrpkPRPAGLEDSNELDEEtgnGQLQLGLKSPESKADESYEEAARAFEKALD 322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981   117 K-KVAAIEALN----------DGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPY 185
Cdd:TIGR00990 323 LgKLGEKEAIAlnlrgtfkclKGKHLEALADLSKSIELDPRVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIY 402

                         170       180
                  ....*....|....*....|....*....
gi 46981981   186 KWRGKAHRLLGHWEEAAHDLALACKLDYD 214
Cdd:TIGR00990 403 YHRAQLHFIKGEFAQAGKDYQKSIDLDPD 431
STI1 pfam17830
STI1 domain; This entry corresponds to the STI1 domain that is found in two copies in the Sti1 ...
 316-361 1.87e-08

STI1 domain; This entry corresponds to the STI1 domain that is found in two copies in the Sti1 protein.


Pssm-ID: 436075  Cd Length: 55  Bit Score: 50.25  E-value: 1.87e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 46981981   316 ILSDPEVLAAMQDPEVMVAFQDVAQNPANMSKYQSNPKVMNLISKL 361
Cdd:pfam17830   8 LAANPETRALLSDPEFVAKLQQIQKNPSSLQQYMQDPRVMTKLGVL 53
TPR_9 pfam13371
Tetratricopeptide repeat;
162-223 4.88e-04

Tetratricopeptide repeat;


Pssm-ID: 463860 [Multi-domain]  Cd Length: 73  Bit Score: 38.35  E-value: 4.88e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 46981981   162 QKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLALACKLDYDEDASAMLKE 223
Cdd:pfam13371   9 EDWERALAVVERLLLLAPDDPEERRDRGLLYAQLGCFQAALEDLEAYLELAPDAPDAEAIRE 70
 
Name Accession Description Interval E-value
Hip_N cd14438
N-terminal dimerization domain of the Hsp70-interacting protein (Hip) and similar proteins; ...
 3-43 2.11e-19

N-terminal dimerization domain of the Hsp70-interacting protein (Hip) and similar proteins; The Hsc70/Hsp70-interacting protein (Hip, also p48 or suppressor of tumorigenicity ST13) functions as a regulator of the cyclic action of Hsp70. Hip forms homodimers, and this model characterizes the N-terminal dimerization domain, which may not be directly involved in its regulatory function. A central domain of Hip that contains TPR repeats binds the ATPase domain of Hsp70 and slows the release of ADP.


Pssm-ID: 271228  Cd Length: 41  Bit Score: 80.28  E-value: 2.11e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 46981981   3 PRKVNELRAFVKMCKQDPSVLHTEEMRFLREWVESMGGKVP 43
Cdd:cd14438   1 PEKLKELKAFVELCKQNPSILHTPELSFFKEYLESLGAKIP 41
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
128-221 3.64e-16

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 76.88  E-value: 3.64e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981 128 GELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLAL 207
Cdd:COG4785  87 GDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEK 166

                        90
                ....*....|....
gi 46981981 208 ACKLDyDEDASAML 221
Cdd:COG4785 167 ALELD-PNDPERAL 179
HipN pfam18253
Hsp70-interacting protein N N-terminal domain; This is the N-terminal domain, known as HipN, ...
 2-43 4.44e-16

Hsp70-interacting protein N N-terminal domain; This is the N-terminal domain, known as HipN, found in Hsp70-interacting protein (Hip) present in Rattus norvegicus. Hip cooperates with the chaperone Hsp70 in protein folding and prevention of aggregation and may delay substrate release by slowing ADP dissociation from Hsp70. HipN is responsible for N-terminal homo-dimerization which is necessary so that the Hip dimer can interact with Hsp70 molecules.


Pssm-ID: 408069  Cd Length: 42  Bit Score: 71.15  E-value: 4.44e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 46981981     2 DPRKVNELRAFVKMCKQDPSVLHTEEMRFLREWVESMGGKVP 43
Cdd:pfam18253   1 DPAHLSLLKQFVDLCKANPSILHLPELAFFKEFLESLGATVP 42
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
128-214 1.09e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.04  E-value: 1.09e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981 128 GELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLAL 207
Cdd:COG0457  56 GRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYER 135


                ....*..
gi 46981981 208 ACKLDYD 214
Cdd:COG0457 136 ALELDPD 142
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
128-214 2.52e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.88  E-value: 2.52e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981 128 GELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLAL 207
Cdd:COG0457  22 GRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDK 101


                ....*..
gi 46981981 208 ACKLDYD 214
Cdd:COG0457 102 ALELDPD 108
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 128-212 4.23e-13

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 70.41  E-value: 4.23e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981 128 GELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLAL 207
Cdd:COG3914 126 GRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRR 205


                ....*
gi 46981981 208 ACKLD 212
Cdd:COG3914 206 ALELD 210
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
128-278 4.60e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.41  E-value: 4.60e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981 128 GELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLAL 207
Cdd:COG0457  90 GRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEK 169

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 46981981 208 ACKLDYDEDASAMLKEVQPRAQKIAEHRRKYERKREEREIKERIERVKKAREEHERAQREEEARRQSGAQY 278
Cdd:COG0457 170 LEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALAL 240
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 111-212 9.77e-12

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 66.17  E-value: 9.77e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981 111 MDQANDKKVAAIEALNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGK 190
Cdd:COG3914  75 LLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGE 154

                        90       100
                ....*....|....*....|..
gi 46981981 191 AHRLLGHWEEAAHDLALACKLD 212
Cdd:COG3914 155 ALRRLGRLEEAIAALRRALELD 176
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
143-221 1.61e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 57.62  E-value: 1.61e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 46981981 143 LNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLALACKLDyDEDASAML 221
Cdd:COG4785  68 ALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELD-PDYAYAYL 145
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 114-233 1.78e-09

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 58.64  E-value: 1.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981  114 ANDKKVAAIEALNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHR 193
Cdd:PLN03088   2 AKDLEDKAKEAFVDDDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACM 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 46981981  194 LLGHWEEAAHDLALACKLDYDEDASA-MLKEVQpraQKIAE 233
Cdd:PLN03088  82 KLEEYQTAKAALEKGASLAPGDSRFTkLIKECD---EKIAE 119
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
141-214 2.68e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.94  E-value: 2.68e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46981981 141 IKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLALACKLDYD 214
Cdd:COG0457   1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPD 74
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 121-212 2.96e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.81  E-value: 2.96e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981 121 AIEALNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEE 200
Cdd:COG4783  11 AQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDE 90

                        90
                ....*....|..
gi 46981981 201 AAHDLALACKLD 212
Cdd:COG4783  91 ALALLEKALKLD 102
STI1 smart00727
Heat shock chaperonin-binding motif;
319-358 4.44e-09

Heat shock chaperonin-binding motif;


Pssm-ID: 128966  Cd Length: 41  Bit Score: 51.50  E-value: 4.44e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 46981981    319 DPEVLAAMQDPEVMVAFQDVAQNPANMSKY-QSNPKVMNLI 358
Cdd:smart00727   1 DPEMALRLQNPQVQSLLQDMQQNPDMLAQMlQENPQLLQLI 41
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
124-214 6.14e-09

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 52.87  E-value: 6.14e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981 124 ALNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRdCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAH 203
Cdd:COG3063   2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALA 80

                        90
                ....*....|.
gi 46981981 204 DLALACKLDYD 214
Cdd:COG3063  81 YLERALELDPS 91
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 124-215 6.34e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.04  E-value: 6.34e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981 124 ALNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAH 203
Cdd:COG4783  48 LLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIA 127

                        90
                ....*....|..
gi 46981981 204 DLALACKLDYDE 215
Cdd:COG4783 128 ALEKALELDPDD 139
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 45-214 1.57e-08

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 56.15  E-value: 1.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981    45 ATQKAKSEENTKEEK-PDSKKVEEDLKA----DEPSSEESDLEIDKE---GVIEPDTDAPQEMGDENAEITEEMMDQAND 116
Cdd:TIGR00990 243 AESKAKEILETKPENlPSVTFVGNYLQSfrpkPRPAGLEDSNELDEEtgnGQLQLGLKSPESKADESYEEAARAFEKALD 322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981   117 K-KVAAIEALN----------DGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPY 185
Cdd:TIGR00990 323 LgKLGEKEAIAlnlrgtfkclKGKHLEALADLSKSIELDPRVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIY 402

                         170       180
                  ....*....|....*....|....*....
gi 46981981   186 KWRGKAHRLLGHWEEAAHDLALACKLDYD 214
Cdd:TIGR00990 403 YHRAQLHFIKGEFAQAGKDYQKSIDLDPD 431
STI1 pfam17830
STI1 domain; This entry corresponds to the STI1 domain that is found in two copies in the Sti1 ...
 316-361 1.87e-08

STI1 domain; This entry corresponds to the STI1 domain that is found in two copies in the Sti1 protein.


Pssm-ID: 436075  Cd Length: 55  Bit Score: 50.25  E-value: 1.87e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 46981981   316 ILSDPEVLAAMQDPEVMVAFQDVAQNPANMSKYQSNPKVMNLISKL 361
Cdd:pfam17830   8 LAANPETRALLSDPEFVAKLQQIQKNPSSLQQYMQDPRVMTKLGVL 53
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 125-223 2.54e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 51.93  E-value: 2.54e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981 125 LNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHD 204
Cdd:COG4235  28 LRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAA 107

                        90
                ....*....|....*....
gi 46981981 205 LALACKLDYDEDASAMLKE 223
Cdd:COG4235 108 WQKLLALLPADAPARLLEA 126
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 47-218 3.33e-08

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 55.38  E-value: 3.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981    47 QKAKSEENTKEEKPDSKKVEedlKADEPSSEESDLEIDKEGVIEPDTDAPQEMGDENAEITEEMMDQ-ANDKKVAAIEAL 125
Cdd:TIGR00990  62 QRESKPKISKKERRKRKQAE---KETEGKTEEKKSTAPKNAPVEPADELPEIDESSVANLSEEERKKyAAKLKEKGNKAY 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981   126 NDGELQKAIDLFTDAIKLNPRlAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDL 205
Cdd:TIGR00990 139 RNKDFNKAIKLYSKAIECKPD-PVYYSNRAACHNALGDWEKVVEDTTAALELDPDYSKALNRRANAYDGLGKYADALLDL 217

                         170
                  ....*....|...
gi 46981981   206 ALACKLDYDEDAS 218
Cdd:TIGR00990 218 TASCIIDGFRNEQ 230
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 121-233 4.44e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.58  E-value: 4.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981 121 AIEALNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEE 200
Cdd:COG2956 151 AELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEE 230

                        90       100       110
                ....*....|....*....|....*....|...
gi 46981981 201 AAHDLALACKLDYDEDASAMLKEVQPRAQKIAE 233
Cdd:COG2956 231 ALELLRKALELDPSDDLLLALADLLERKEGLEA 263
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 111-212 1.00e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 51.11  E-value: 1.00e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981 111 MDQANDKKVAAIEALNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGK 190
Cdd:COG5010  51 AKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAA 130

                        90       100
                ....*....|....*....|..
gi 46981981 191 AHRLLGHWEEAAHDLALACKLD 212
Cdd:COG5010 131 LLLSLGQDDEAKAALQRALGTS 152
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 102-214 2.35e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.65  E-value: 2.35e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981 102 ENAEITEEMMDQANDKKVAAIEAL-----NDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIE 176
Cdd:COG2956  93 DRAEELLEKLLELDPDDAEALRLLaeiyeQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALK 172

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 46981981 177 INPDSAQPYKWRGKAHRLLGHWEEAAHDLALACKLDYD 214
Cdd:COG2956 173 LDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPD 210
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 119-221 7.81e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 50.11  E-value: 7.81e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981 119 VAAIEALNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHW 198
Cdd:COG2956  13 FKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLL 92

                        90       100
                ....*....|....*....|....
gi 46981981 199 EEAAHDLALACKLD-YDEDASAML 221
Cdd:COG2956  93 DRAEELLEKLLELDpDDAEALRLL 116
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
125-196 9.23e-07

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 49.14  E-value: 9.23e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 46981981 125 LNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLG 196
Cdd:COG4785 118 LLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERALWLYLAERKLD 189
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 108-221 3.56e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 48.84  E-value: 3.56e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981 108 EEMMDQANDKKVAAIEALNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKW 187
Cdd:COG3914  38 AAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFN 117

                        90       100       110
                ....*....|....*....|....*....|....
gi 46981981 188 RGKAHRLLGHWEEAAHDLALACKLDYDeDASAML 221
Cdd:COG3914 118 LGNLLLALGRLEEALAALRRALALNPD-FAEAYL 150
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 105-233 4.23e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.80  E-value: 4.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981 105 EITEEMMDQANDKKVAAIE----ALNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPD 180
Cdd:COG2956  63 RIHQKLLERDPDRAEALLElaqdYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPE 142

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 46981981 181 SAQPYKWRGKAHRLLGHWEEAAHDLALACKLD-YDEDASAMLKEVQPRAQKIAE 233
Cdd:COG2956 143 NAHAYCELAELYLEQGDYDEAIEALEKALKLDpDCARALLLLAELYLEQGDYEE 196
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 128-219 6.25e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.98  E-value: 6.25e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981 128 GELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLAL 207
Cdd:COG3914 160 GRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDRFEEL 239

                        90
                ....*....|..
gi 46981981 208 ACKLDYDEDASA 219
Cdd:COG3914 240 LAALARGPSELS 251
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 112-214 8.59e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 42.64  E-value: 8.59e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981 112 DQANDKKVAAIEALNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKA 191
Cdd:COG5010  18 TKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALL 97

                        90       100
                ....*....|....*....|...
gi 46981981 192 HRLLGHWEEAAHDLALACKLDYD 214
Cdd:COG5010  98 YSRSGDKDEAKEYYEKALALSPD 120
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 132-221 1.44e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 41.14  E-value: 1.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981 132 KAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLALACKL 211
Cdd:COG4235   1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80

                        90
                ....*....|
gi 46981981 212 DYDEDASAML 221
Cdd:COG4235  81 DPDNPEALYL 90
TPR_9 pfam13371
Tetratricopeptide repeat;
162-223 4.88e-04

Tetratricopeptide repeat;


Pssm-ID: 463860 [Multi-domain]  Cd Length: 73  Bit Score: 38.35  E-value: 4.88e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 46981981   162 QKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLALACKLDYDEDASAMLKE 223
Cdd:pfam13371   9 EDWERALAVVERLLLLAPDDPEERRDRGLLYAQLGCFQAALEDLEAYLELAPDAPDAEAIRE 70
TPR_1 pfam00515
Tetratricopeptide repeat;
148-180 2.68e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 35.09  E-value: 2.68e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 46981981   148 AILYAKRASVFVKLQKPNAAIRDCDRAIEINPD 180
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPN 33
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 146-215 5.01e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.09  E-value: 5.01e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46981981 146 RLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLALACKLDYDE 215
Cdd:COG4783   2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDE 71
TPR_11 pfam13414
TPR repeat;
157-196 5.09e-03

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 34.37  E-value: 5.09e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 46981981   157 VFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLG 196
Cdd:pfam13414   3 AYYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKLG 42
SirB1 COG2912
Regulator of sirC expression, contains transglutaminase-like and TPR domains [Signal ...
 162-223 8.19e-03

Regulator of sirC expression, contains transglutaminase-like and TPR domains [Signal transduction mechanisms];


Pssm-ID: 442156 [Multi-domain]  Cd Length: 264  Bit Score: 37.50  E-value: 8.19e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46981981 162 QKPNAAIRDCDRAIEINPDSaqPYKWR--GKAHRLLGHWEEAAHDLALACKLDYDEDASAMLKE 223
Cdd:COG2912 193 KDWERALRVVERLLLLDPDD--PYEIRdrGLLYAQLGCYQAALEDLEYFLEQCPEDPDAELIKE 254
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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