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Conserved domains on  [gi|50542217|gb|AAT78448|]
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histone H4, partial [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00015 super family cl29688
histone H4; Provisional
 1-43 9.25e-21

histone H4; Provisional


The actual alignment was detected with superfamily member PTZ00015:

Pssm-ID: 185397  Cd Length: 102  Bit Score: 76.70  E-value: 9.25e-21
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 50542217    1 KPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYT 43
Cdd:PTZ00015  33 KGAIRRLARRGGVKRISGDIYEEVRGVLKAFLENVVRDSTAYT 75
 
Name Accession Description Interval E-value
PTZ00015 PTZ00015
histone H4; Provisional
 1-43 9.25e-21

histone H4; Provisional


Pssm-ID: 185397  Cd Length: 102  Bit Score: 76.70  E-value: 9.25e-21
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 50542217    1 KPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYT 43
Cdd:PTZ00015  33 KGAIRRLARRGGVKRISGDIYEEVRGVLKAFLENVVRDSTAYT 75
HFD_H4 cd22912
histone-fold domain found in histone H4 and similar proteins; Histone H4 is a core component ...
 1-43 5.35e-20

histone-fold domain found in histone H4 and similar proteins; Histone H4 is a core component of the nucleosome, which wraps and compacts DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication, and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called the histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.


Pssm-ID: 467037 [Multi-domain]  Cd Length: 79  Bit Score: 74.18  E-value: 5.35e-20
                       10        20        30        40
               ....*....|....*....|....*....|....*....|...
gi 50542217  1 KPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYT 43
Cdd:cd22912 11 KPAIRRLARRGGVKRISGDIYEEVRGVLKDFLENVIRDAVTYT 53
H4 smart00417
Histone H4;
1-43 4.95e-18

Histone H4;


Pssm-ID: 128694  Cd Length: 74  Bit Score: 69.11  E-value: 4.95e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 50542217     1 KPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYT 43
Cdd:smart00417 16 KPAIRRLARRGGVKRISGLIYDETRNVLKSFLENVVRDAVTYT 58
 
Name Accession Description Interval E-value
PTZ00015 PTZ00015
histone H4; Provisional
 1-43 9.25e-21

histone H4; Provisional


Pssm-ID: 185397  Cd Length: 102  Bit Score: 76.70  E-value: 9.25e-21
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 50542217    1 KPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYT 43
Cdd:PTZ00015  33 KGAIRRLARRGGVKRISGDIYEEVRGVLKAFLENVVRDSTAYT 75
HFD_H4 cd22912
histone-fold domain found in histone H4 and similar proteins; Histone H4 is a core component ...
 1-43 5.35e-20

histone-fold domain found in histone H4 and similar proteins; Histone H4 is a core component of the nucleosome, which wraps and compacts DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication, and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called the histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.


Pssm-ID: 467037 [Multi-domain]  Cd Length: 79  Bit Score: 74.18  E-value: 5.35e-20
                       10        20        30        40
               ....*....|....*....|....*....|....*....|...
gi 50542217  1 KPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYT 43
Cdd:cd22912 11 KPAIRRLARRGGVKRISGDIYEEVRGVLKDFLENVIRDAVTYT 53
PLN00035 PLN00035
histone H4; Provisional
 1-43 3.51e-19

histone H4; Provisional


Pssm-ID: 177669 [Multi-domain]  Cd Length: 103  Bit Score: 72.56  E-value: 3.51e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 50542217    1 KPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYT 43
Cdd:PLN00035  32 KPAIRRLARRGGVKRISGLIYEETRGVLKIFLENVIRDAVTYT 74
H4 smart00417
Histone H4;
1-43 4.95e-18

Histone H4;


Pssm-ID: 128694  Cd Length: 74  Bit Score: 69.11  E-value: 4.95e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 50542217     1 KPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYT 43
Cdd:smart00417 16 KPAIRRLARRGGVKRISGLIYDETRNVLKSFLENVVRDAVTYT 58
PLN00163 PLN00163
histone H4; Provisional
 1-28 2.94e-08

histone H4; Provisional


Pssm-ID: 165730  Cd Length: 59  Bit Score: 43.91  E-value: 2.94e-08
                        10        20
                ....*....|....*....|....*...
gi 50542217   1 KPAIRRLARRGGVKRISGLIYEETRGVL 28
Cdd:PLN00163 32 KPAIRRLARRGGVKRISGLIYEETRTVL 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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