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Conserved domains on  [gi|62822538|gb|AAY15086|]
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unknown, partial [Homo sapiens]

Protein Classification

HELP and WD40 domain-containing protein( domain architecture ID 13687743)

HELP and WD40 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 158-226 1.99e-34

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


:

Pssm-ID: 460922  Cd Length: 72  Bit Score: 125.74  E-value: 1.99e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62822538   158 KMFMRGRPITMFIPSD-VDNYD-DIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFN 226
Cdd:pfam03451   1 KMAIRGRPGAVYPPSNyYPKDDlDQKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYD 71
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 432-793 2.81e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 112.81  E-value: 2.81e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 432 SKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDhdlnpereievpdqygtiravaegkadqflvgtsrnfilrgTFN 511
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD-----------------------------------------LET 40

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 512 DGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTrLVdepGH-----CADFHPSGTVVAIGTHSGR 586
Cdd:cd00200  41 GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT-LT---GHtsyvsSVAFSPDGRILSSSSRDKT 116

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 587 WFVLDAETRDLVSI---HTDgneqlSVM--RYSIDGTFLAVGSHDNFIYLYvvseNGRKYSRYGRCTGHSSYITHLDWSP 661
Cdd:cd00200 117 IKVWDVETGKCLTTlrgHTD-----WVNsvAFSPDGTFVASSSQDGTIKLW----DLRTGKCVATLTGHTGEVNSVAFSP 187

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 662 DNKYIMSNSGDYEILYWDIPNGcklirnrsdckdidwttyTCVLGFQVFGVWpegsdgtdINALVRSHNRKVIAVADDFC 741
Cdd:cd00200 188 DGEKLLSSSSDGTIKLWDLSTG------------------KCLGTLRGHENG--------VNSVAFSPDGYLLASGSEDG 241

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|..
gi 62822538 742 KVHLFQypcSKAKAPSHKYSAHSSHVTNVSFtHNDSHLISTGGKDMSIIQWK 793
Cdd:cd00200 242 TIRVWD---LRTGECVQTLSGHTNSVTSLAW-SPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
245-682 5.22e-26

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.54  E-value: 5.22e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 245 LAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIigLGTFERGVGCLDFSKADSGvhlcIIDDSNEHMLTVW 324
Cdd:COG2319  32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLAT--LLGHTAAVLSVAFSPDGRL----LASASADGTVRLW 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 325 DWQKKAKGAEIKTTNEVVLAVEFHPtDANTIITCGKSH-IFFWTW-SGNSLTRKQGifgkyeKPKFVQCLAFLGNGDVL- 401
Cdd:COG2319 106 DLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGtVRLWDLaTGKLLRTLTG------HSGAVTSVAFSPDGKLLa 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 402 TGDSGGVMLIWSKTTVEPTpgkgpkgvyqisKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDhdlnpereievpdq 481
Cdd:COG2319 179 SGSDDGTVRLWDLATGKLL------------RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD-------------- 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 482 ygtiraVAEGKADQFLvgtsrnfilrgtfndgfqievQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNsmehrLEWTRL 561
Cdd:COG2319 233 ------LATGKLLRTL---------------------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWD-----LATGEL 280

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 562 VDEPGHCAD------FHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYvvs 635
Cdd:COG2319 281 LRTLTGHSGgvnsvaFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW--- 357

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*..
gi 62822538 636 eNGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPN 682
Cdd:COG2319 358 -DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
 
Name Accession Description Interval E-value
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 158-226 1.99e-34

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 125.74  E-value: 1.99e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62822538   158 KMFMRGRPITMFIPSD-VDNYD-DIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFN 226
Cdd:pfam03451   1 KMAIRGRPGAVYPPSNyYPKDDlDQKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYD 71
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 432-793 2.81e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.81  E-value: 2.81e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 432 SKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDhdlnpereievpdqygtiravaegkadqflvgtsrnfilrgTFN 511
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD-----------------------------------------LET 40

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 512 DGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTrLVdepGH-----CADFHPSGTVVAIGTHSGR 586
Cdd:cd00200  41 GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT-LT---GHtsyvsSVAFSPDGRILSSSSRDKT 116

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 587 WFVLDAETRDLVSI---HTDgneqlSVM--RYSIDGTFLAVGSHDNFIYLYvvseNGRKYSRYGRCTGHSSYITHLDWSP 661
Cdd:cd00200 117 IKVWDVETGKCLTTlrgHTD-----WVNsvAFSPDGTFVASSSQDGTIKLW----DLRTGKCVATLTGHTGEVNSVAFSP 187

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 662 DNKYIMSNSGDYEILYWDIPNGcklirnrsdckdidwttyTCVLGFQVFGVWpegsdgtdINALVRSHNRKVIAVADDFC 741
Cdd:cd00200 188 DGEKLLSSSSDGTIKLWDLSTG------------------KCLGTLRGHENG--------VNSVAFSPDGYLLASGSEDG 241

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|..
gi 62822538 742 KVHLFQypcSKAKAPSHKYSAHSSHVTNVSFtHNDSHLISTGGKDMSIIQWK 793
Cdd:cd00200 242 TIRVWD---LRTGECVQTLSGHTNSVTSLAW-SPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
438-794 9.51e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.85  E-value: 9.51e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 438 HDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDlNPEREIEVPDQYGTIRAVA---EGKadQFLVGTSRNFILRGTFNDGF 514
Cdd:COG2319  77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLA-TGLLLRTLTGHTGAVRSVAfspDGK--TLASGSADGTVRLWDLATGK 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 515 QI-EVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWT-RLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDA 592
Cdd:COG2319 154 LLrTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTlTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 593 ETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVsENGRKYSRYgrcTGHSSYITHLDWSPDNKYIMSNSGD 672
Cdd:COG2319 234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL-ATGELLRTL---TGHSGGVNSVAFSPDGKLLASGSDD 309

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 673 YEILYWDIPNGcKLIRnrsdckdidwttytcvlgfqvfgvWPEGSDGtDINALVRSHNRKVIAVADDFCKVHLFQypcSK 752
Cdd:COG2319 310 GTVRLWDLATG-KLLR------------------------TLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWD---LA 360

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 62822538 753 AKAPSHKYSAHSSHVTNVSFTHNDSHLIStGGKDMSIIQWKL 794
Cdd:COG2319 361 TGELLRTLTGHTGAVTSVAFSPDGRTLAS-GSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
245-682 5.22e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.54  E-value: 5.22e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 245 LAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIigLGTFERGVGCLDFSKADSGvhlcIIDDSNEHMLTVW 324
Cdd:COG2319  32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLAT--LLGHTAAVLSVAFSPDGRL----LASASADGTVRLW 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 325 DWQKKAKGAEIKTTNEVVLAVEFHPtDANTIITCGKSH-IFFWTW-SGNSLTRKQGifgkyeKPKFVQCLAFLGNGDVL- 401
Cdd:COG2319 106 DLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGtVRLWDLaTGKLLRTLTG------HSGAVTSVAFSPDGKLLa 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 402 TGDSGGVMLIWSKTTVEPTpgkgpkgvyqisKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDhdlnpereievpdq 481
Cdd:COG2319 179 SGSDDGTVRLWDLATGKLL------------RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD-------------- 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 482 ygtiraVAEGKADQFLvgtsrnfilrgtfndgfqievQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNsmehrLEWTRL 561
Cdd:COG2319 233 ------LATGKLLRTL---------------------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWD-----LATGEL 280

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 562 VDEPGHCAD------FHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYvvs 635
Cdd:COG2319 281 LRTLTGHSGgvnsvaFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW--- 357

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*..
gi 62822538 636 eNGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPN 682
Cdd:COG2319 358 -DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 233-586 9.18e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.47  E-value: 9.18e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 233 RHYLGHTDCVKCLAIHPDKIRIATGqiagvDKDGRplqphVRVWDSVTLStlQIIGLGTFERGVGCLDFSkADSGvhlCI 312
Cdd:cd00200   3 RTLKGHTGGVTCVAFSPDGKLLATG-----SGDGT-----IKVWDLETGE--LLRTLKGHTGPVRDVAAS-ADGT---YL 66

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 313 IDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTdaNTIITCGKSH--IFFWTW-SGNSLTRKQGIFGkyekpkFV 389
Cdd:cd00200  67 ASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPD--GRILSSSSRDktIKVWDVeTGKCLTTLRGHTD------WV 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 390 QCLAFLGNGDVLTGDSG-GVMLIWSKTTVEPTpgkgpkgvyqisKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDH 468
Cdd:cd00200 139 NSVAFSPDGTFVASSSQdGTIKLWDLRTGKCV------------ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 469 dlnpereievpdqygtiravaegkadqflvgtsRNFILRGTFndgfqievQGHTDELWGLATHPFKDLLLTCAQDRQVCL 548
Cdd:cd00200 207 ---------------------------------STGKCLGTL--------RGHENGVNSVAFSPDGYLLASGSEDGTIRV 245

                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 62822538 549 WNsMEHRLEWTRLV--DEPGHCADFHPSGTVVAIGTHSGR 586
Cdd:cd00200 246 WD-LRTGECVQTLSghTNSVTSLAWSPDGKRLASGSADGT 284
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 647-679 8.61e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 8.61e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 62822538    647 CTGHSSYITHLDWSPDNKYIMSNSGDYEILYWD 679
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
648-679 1.27e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.27e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 62822538   648 TGHSSYITHLDWSPDNKYIMSNSGDYEILYWD 679
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 158-226 1.99e-34

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 125.74  E-value: 1.99e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62822538   158 KMFMRGRPITMFIPSD-VDNYD-DIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFN 226
Cdd:pfam03451   1 KMAIRGRPGAVYPPSNyYPKDDlDQKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYD 71
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 432-793 2.81e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.81  E-value: 2.81e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 432 SKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDhdlnpereievpdqygtiravaegkadqflvgtsrnfilrgTFN 511
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD-----------------------------------------LET 40

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 512 DGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTrLVdepGH-----CADFHPSGTVVAIGTHSGR 586
Cdd:cd00200  41 GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT-LT---GHtsyvsSVAFSPDGRILSSSSRDKT 116

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 587 WFVLDAETRDLVSI---HTDgneqlSVM--RYSIDGTFLAVGSHDNFIYLYvvseNGRKYSRYGRCTGHSSYITHLDWSP 661
Cdd:cd00200 117 IKVWDVETGKCLTTlrgHTD-----WVNsvAFSPDGTFVASSSQDGTIKLW----DLRTGKCVATLTGHTGEVNSVAFSP 187

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 662 DNKYIMSNSGDYEILYWDIPNGcklirnrsdckdidwttyTCVLGFQVFGVWpegsdgtdINALVRSHNRKVIAVADDFC 741
Cdd:cd00200 188 DGEKLLSSSSDGTIKLWDLSTG------------------KCLGTLRGHENG--------VNSVAFSPDGYLLASGSEDG 241

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|..
gi 62822538 742 KVHLFQypcSKAKAPSHKYSAHSSHVTNVSFtHNDSHLISTGGKDMSIIQWK 793
Cdd:cd00200 242 TIRVWD---LRTGECVQTLSGHTNSVTSLAW-SPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
438-794 9.51e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.85  E-value: 9.51e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 438 HDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDlNPEREIEVPDQYGTIRAVA---EGKadQFLVGTSRNFILRGTFNDGF 514
Cdd:COG2319  77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLA-TGLLLRTLTGHTGAVRSVAfspDGK--TLASGSADGTVRLWDLATGK 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 515 QI-EVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWT-RLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDA 592
Cdd:COG2319 154 LLrTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTlTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 593 ETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVsENGRKYSRYgrcTGHSSYITHLDWSPDNKYIMSNSGD 672
Cdd:COG2319 234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL-ATGELLRTL---TGHSGGVNSVAFSPDGKLLASGSDD 309

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 673 YEILYWDIPNGcKLIRnrsdckdidwttytcvlgfqvfgvWPEGSDGtDINALVRSHNRKVIAVADDFCKVHLFQypcSK 752
Cdd:COG2319 310 GTVRLWDLATG-KLLR------------------------TLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWD---LA 360

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 62822538 753 AKAPSHKYSAHSSHVTNVSFTHNDSHLIStGGKDMSIIQWKL 794
Cdd:COG2319 361 TGELLRTLTGHTGAVTSVAFSPDGRTLAS-GSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
245-682 5.22e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.54  E-value: 5.22e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 245 LAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIigLGTFERGVGCLDFSKADSGvhlcIIDDSNEHMLTVW 324
Cdd:COG2319  32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLAT--LLGHTAAVLSVAFSPDGRL----LASASADGTVRLW 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 325 DWQKKAKGAEIKTTNEVVLAVEFHPtDANTIITCGKSH-IFFWTW-SGNSLTRKQGifgkyeKPKFVQCLAFLGNGDVL- 401
Cdd:COG2319 106 DLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGtVRLWDLaTGKLLRTLTG------HSGAVTSVAFSPDGKLLa 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 402 TGDSGGVMLIWSKTTVEPTpgkgpkgvyqisKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDhdlnpereievpdq 481
Cdd:COG2319 179 SGSDDGTVRLWDLATGKLL------------RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD-------------- 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 482 ygtiraVAEGKADQFLvgtsrnfilrgtfndgfqievQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNsmehrLEWTRL 561
Cdd:COG2319 233 ------LATGKLLRTL---------------------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWD-----LATGEL 280

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 562 VDEPGHCAD------FHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYvvs 635
Cdd:COG2319 281 LRTLTGHSGgvnsvaFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW--- 357

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*..
gi 62822538 636 eNGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPN 682
Cdd:COG2319 358 -DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 386-679 1.96e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.26  E-value: 1.96e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 386 PKFVQCLAFLGNGDVL-TGDSGGVMLIWSKTTVEPtpgkgpkgvyqiSKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKII 464
Cdd:cd00200   9 TGGVTCVAFSPDGKLLaTGSGDGTIKVWDLETGEL------------LRTLKGHTGPVRDVAASADGTYLASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 465 LWD-HDLNPEREIEVPDQYgtIRAVAEGKADQFLVGTSRNFILR--GTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCA 541
Cdd:cd00200  77 LWDlETGECVRTLTGHTSY--VSSVAFSPDGRILSSSSRDKTIKvwDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSS 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 542 QDRQVCLWNSMEHRLEWTRlvdePGH-----CADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSID 616
Cdd:cd00200 155 QDGTIKLWDLRTGKCVATL----TGHtgevnSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD 230

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62822538 617 GTFLAVGSHDNFIYLYvvseNGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWD 679
Cdd:cd00200 231 GYLLASGSEDGTIRVW----DLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
321-683 3.74e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 3.74e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 321 LTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWTWSGNSLTRKQGIFGKyekpkFVQCLAFLGNGDV 400
Cdd:COG2319  18 LALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA-----AVLSVAFSPDGRL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 401 L-TGDSGGVMLIWSKTTVEPTPgkgpkgvyqiskQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWD-HDLNPEREIEV 478
Cdd:COG2319  93 LaSASADGTVRLWDLATGLLLR------------TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDlATGKLLRTLTG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 479 PDqyGTIRAVAEGKADQFLVGTSRNFILR--GTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNsMEHRL 556
Cdd:COG2319 161 HS--GAVTSVAFSPDGKLLASGSDDGTVRlwDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD-LATGK 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 557 EWTRLVDEPG--HCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVV 634
Cdd:COG2319 238 LLRTLTGHSGsvRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL 317

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|...
gi 62822538 635 SEngrkysryGRC----TGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNG 683
Cdd:COG2319 318 AT--------GKLlrtlTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG 362
WD40 COG2319
WD40 repeat [General function prediction only];
449-794 6.38e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.13  E-value: 6.38e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 449 RNGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDG-FQIEVQGHTDELWG 527
Cdd:COG2319   4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGaLLATLLGHTAAVLS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 528 LATHPFKDLLLTCAQDRQVCLWN-SMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNE 606
Cdd:COG2319  84 VAFSPDGRLLASASADGTVRLWDlATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSG 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 607 QLSVMRYSIDGTFLAVGSHDNFIYLYVVsENGRKYSRYgrcTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGcKL 686
Cdd:COG2319 164 AVTSVAFSPDGKLLASGSDDGTVRLWDL-ATGKLLRTL---TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG-KL 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 687 IRnrsdckdidwttytcvlgfqvfgvwPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQypcSKAKAPSHKYSAHSSH 766
Cdd:COG2319 239 LR-------------------------TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD---LATGELLRTLTGHSGG 290

                       330       340
                ....*....|....*....|....*...
gi 62822538 767 VTNVSFTHNDSHLIStGGKDMSIIQWKL 794
Cdd:COG2319 291 VNSVAFSPDGKLLAS-GSDDGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 233-586 9.18e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.47  E-value: 9.18e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 233 RHYLGHTDCVKCLAIHPDKIRIATGqiagvDKDGRplqphVRVWDSVTLStlQIIGLGTFERGVGCLDFSkADSGvhlCI 312
Cdd:cd00200   3 RTLKGHTGGVTCVAFSPDGKLLATG-----SGDGT-----IKVWDLETGE--LLRTLKGHTGPVRDVAAS-ADGT---YL 66

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 313 IDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTdaNTIITCGKSH--IFFWTW-SGNSLTRKQGIFGkyekpkFV 389
Cdd:cd00200  67 ASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPD--GRILSSSSRDktIKVWDVeTGKCLTTLRGHTD------WV 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 390 QCLAFLGNGDVLTGDSG-GVMLIWSKTTVEPTpgkgpkgvyqisKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDH 468
Cdd:cd00200 139 NSVAFSPDGTFVASSSQdGTIKLWDLRTGKCV------------ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 469 dlnpereievpdqygtiravaegkadqflvgtsRNFILRGTFndgfqievQGHTDELWGLATHPFKDLLLTCAQDRQVCL 548
Cdd:cd00200 207 ---------------------------------STGKCLGTL--------RGHENGVNSVAFSPDGYLLASGSEDGTIRV 245

                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 62822538 549 WNsMEHRLEWTRLV--DEPGHCADFHPSGTVVAIGTHSGR 586
Cdd:cd00200 246 WD-LRTGECVQTLSghTNSVTSLAWSPDGKRLASGSADGT 284
WD40 COG2319
WD40 repeat [General function prediction only];
210-550 1.33e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.20  E-value: 1.33e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 210 PTGKIvyfIASV-----VVLFNYEERTQRHYL-GHTDCVKCLAIHPDKIRIATGqiagvDKDGRplqphVRVWDSVTLST 283
Cdd:COG2319 130 PDGKT---LASGsadgtVRLWDLATGKLLRTLtGHSGAVTSVAFSPDGKLLASG-----SDDGT-----VRLWDLATGKL 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 284 LQIigLGTFERGVGCLDFSkADSGVhlcIIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPtDANTIITCGKSH- 362
Cdd:COG2319 197 LRT--LTGHTGAVRSVAFS-PDGKL---LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGt 269

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 363 IFFWTW-SGNSLTRKQGIFGKyekpkfVQCLAFLGNGDVL-TGDSGGVMLIWSKTTVEPTpgkgpkgvyqisKQIKAHDG 440
Cdd:COG2319 270 VRLWDLaTGELLRTLTGHSGG------VNSVAFSPDGKLLaSGSDDGTVRLWDLATGKLL------------RTLTGHTG 331

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 441 SVFTLCQMRNGMLLTGGGKDRKIILWDhdlnpereievpdqygtiraVAEGKADQFLvgtsrnfilrgtfndgfqievQG 520
Cdd:COG2319 332 AVRSVAFSPDGKTLASGSDDGTVRLWD--------------------LATGELLRTL---------------------TG 370

                       330       340       350
                ....*....|....*....|....*....|
gi 62822538 521 HTDELWGLATHPFKDLLLTCAQDRQVCLWN 550
Cdd:COG2319 371 HTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
487-794 8.32e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.89  E-value: 8.32e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 487 AVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLV-DEP 565
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGhTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 566 GHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVsENGRKYSRYg 645
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTL- 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 646 rcTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGcKLIRnrsdckdidwttytcvlgfqvfgVWPEGSDGtdINAL 725
Cdd:COG2319 159 --TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLR-----------------------TLTGHTGA--VRSV 210

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62822538 726 VRSHNRKVIAVADDFCKVHLFQypcSKAKAPSHKYSAHSSHVTNVSFTHnDSHLISTGGKDMSIIQWKL 794
Cdd:COG2319 211 AFSPDGKLLASGSADGTVRLWD---LATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDL 275
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 224-550 3.72e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 3.72e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 224 LFNYEERTQRHYL-GHTDCVKCLAIHPDKIRIATGqiaGVDKDgrplqphVRVWDSVTLSTLQIigLGTFERGVGCLDFS 302
Cdd:cd00200  35 VWDLETGELLRTLkGHTGPVRDVAASADGTYLASG---SSDKT-------IRLWDLETGECVRT--LTGHTSYVSSVAFS 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 303 KaDSGVHLCIIDDSNehmLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTdaNTIITCGKS--HIFFWtwSGNSLTRKQGIF 380
Cdd:cd00200 103 P-DGRILSSSSRDKT---IKVWDVETGKCLTTLRGHTDWVNSVAFSPD--GTFVASSSQdgTIKLW--DLRTGKCVATLT 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 381 GKYekpKFVQCLAFLGNG-DVLTGDSGGVMLIWSKTTVeptpgkgpkgvyQISKQIKAHDGSVFTLCQMRNGMLLTGGGK 459
Cdd:cd00200 175 GHT---GEVNSVAFSPDGeKLLSSSSDGTIKLWDLSTG------------KCLGTLRGHENGVNSVAFSPDGYLLASGSE 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 460 DRKIILWDhdlnpereievpdqygtiravaegkadqflvgtSRNFILRGTFndgfqievQGHTDELWGLATHPFKDLLLT 539
Cdd:cd00200 240 DGTIRVWD---------------------------------LRTGECVQTL--------SGHTNSVTSLAWSPDGKRLAS 278

                       330
                ....*....|.
gi 62822538 540 CAQDRQVCLWN 550
Cdd:cd00200 279 GSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 517-794 9.95e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.83  E-value: 9.95e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 517 EVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNsMEHRLEWTRLVdepGHcadfhpsgtvvaigTHSGRWFVLDAetrd 596
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD-LETGELLRTLK---GH--------------TGPVRDVAASA---- 61

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 597 lvsihtdgneqlsvmrysiDGTFLAVGSHDNFIYLYVVsENGRKYSRYgrcTGHSSYITHLDWSPDNKYIMSNSGDYEIL 676
Cdd:cd00200  62 -------------------DGTYLASGSSDKTIRLWDL-ETGECVRTL---TGHTSYVSSVAFSPDGRILSSSSRDKTIK 118

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 677 YWDIPNGcKLIRNRSDCKDidwttytcvlgfqvfgvwpegsdgtDINALVRSHNRKVIAVADDFCKVHLFQYPCSKakaP 756
Cdd:cd00200 119 VWDVETG-KCLTTLRGHTD-------------------------WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK---C 169

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 62822538 757 SHKYSAHSSHVTNVSFTHNDSHLISTGGkDMSIIQWKL 794
Cdd:cd00200 170 VATLTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDL 206
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 557-677 2.63e-05

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 45.43  E-value: 2.63e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 557 EWTRLVDEPGHCAD--FHPSGTVVAIGT-HSGRW--FVLDAETRDLVSIHTDGNEQLSVmRYSIDGTFLAVGSH-DNFIY 630
Cdd:COG0823  22 EPRRLTNSPGIDTSpaWSPDGRRIAFTSdRGGGPqiYVVDADGGEPRRLTFGGGYNASP-SWSPDGKRLAFVSRsDGRFD 100

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 62822538 631 LYVVSENGRKYSRYGRCTGHSSyithldWSPDNKYIM--SNSGDYEILY 677
Cdd:COG0823 101 IYVLDLDGGAPRRLTDGPGSPS------WSPDGRRIVfsSDRGGRPDLY 143
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 647-679 8.61e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 8.61e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 62822538    647 CTGHSSYITHLDWSPDNKYIMSNSGDYEILYWD 679
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
648-679 1.27e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.27e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 62822538   648 TGHSSYITHLDWSPDNKYIMSNSGDYEILYWD 679
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
519-550 1.79e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.79e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 62822538   519 QGHTDELWGLATHPFKDLLLTCAQDRQVCLWN 550
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 519-550 2.30e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 2.30e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 62822538    519 QGHTDELWGLATHPFKDLLLTCAQDRQVCLWN 550
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 577-683 4.85e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 38.50  E-value: 4.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822538 577 VVAIGTHSGRW--FVLDAETRDLVSIhTDGNEQLSVMRYSIDGTFLAVGSHDNFIY-LYVVSENGRKYSRYgrcTGHSSY 653
Cdd:COG0823   1 LAFTLSRDGNSdiYVVDLDGGEPRRL-TNSPGIDTSPAWSPDGRRIAFTSDRGGGPqIYVVDADGGEPRRL---TFGGGY 76

                        90       100       110
                ....*....|....*....|....*....|...
gi 62822538 654 ITHLDWSPDNKYIM---SNSGDYEILYWDIPNG 683
Cdd:COG0823  77 NASPSWSPDGKRLAfvsRSDGRFDIYVLDLDGG 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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