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Conserved domains on  [gi|77417445|gb|ABA82065|]
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engrailed 2, partial [Neotoma mexicana]

Protein Classification

homeobox domain-containing protein( domain architecture ID 21)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

CATH:  1.10.10.60
Gene Ontology:  GO:0003677
PubMed:  26464018|1357790
SCOP:  4000291

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain super family cl47488
Homeodomain;
7-48 2.35e-10

Homeodomain;


The actual alignment was detected with superfamily member pfam00046:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 49.42  E-value: 2.35e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 77417445    7 KRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNES 48
Cdd:pfam00046  1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTER 42
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
7-48 2.35e-10

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 49.42  E-value: 2.35e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 77417445    7 KRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNES 48
Cdd:pfam00046  1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTER 42
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 7-48 6.77e-09

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 45.70  E-value: 6.77e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 77417445     7 KRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNES 48
Cdd:smart00389  2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSER 43
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 7-48 7.67e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 43.00  E-value: 7.67e-08
                       10        20        30        40
               ....*....|....*....|....*....|....*....|..
gi 77417445  7 KRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNES 48
Cdd:cd00086  1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTER 42
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
7-48 2.35e-10

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 49.42  E-value: 2.35e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 77417445    7 KRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNES 48
Cdd:pfam00046  1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTER 42
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 7-48 6.77e-09

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 45.70  E-value: 6.77e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 77417445     7 KRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNES 48
Cdd:smart00389  2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSER 43
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 7-48 7.67e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 43.00  E-value: 7.67e-08
                       10        20        30        40
               ....*....|....*....|....*....|....*....|..
gi 77417445  7 KRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNES 48
Cdd:cd00086  1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTER 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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