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Conserved domains on  [gi|83656978|gb|ABC39655|]
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oxytetracycline resistance protein, partial [Klebsiella sp. OO-A5-6]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-129 4.75e-51

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17388:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 385  Bit Score: 166.66  E-value: 4.75e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATGAVAASVVADSTAVSERTAWFGRLGAAFGAGL 80
Cdd:cd17388  60 ALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGF 139

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 83656978  81 IAGPAIGGLAGDISPHLPFVIAAILNACTFLMVFFIFKPAVQTEEKPAE 129
Cdd:cd17388 140 IAGPALGGLLGEISPRAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAF 188
 
Name Accession Description Interval E-value
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 1-129 4.75e-51

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 166.66  E-value: 4.75e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATGAVAASVVADSTAVSERTAWFGRLGAAFGAGL 80
Cdd:cd17388  60 ALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGF 139

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 83656978  81 IAGPAIGGLAGDISPHLPFVIAAILNACTFLMVFFIFKPAVQTEEKPAE 129
Cdd:cd17388 140 IAGPALGGLLGEISPRAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAF 188
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-118 8.73e-13

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 63.84  E-value: 8.73e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGI-TGATGAVAASVVADSTAVSERTAWFGRLGAAFGAG 79
Cdd:COG2814  67 RLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLgAGALFPAALALIADLVPPERRGRALGLLGAGLGLG 146

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 83656978  80 LIAGPAIGGLAGD-ISPHLPFVIAAILNACTFLMVFFIFK 118
Cdd:COG2814 147 PALGPLLGGLLADlFGWRWVFLVNAVLALLALLLLLRLLP 186
MFS_1 pfam07690
Major Facilitator Superfamily;
1-145 1.91e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 62.82  E-value: 1.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978     1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATG-AVAASVVADSTAVSERTAWFGRLGAAFGAG 79
Cdd:pfam07690  54 RLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALfPAALALIADWFPPEERGRALGLVSAGFGLG 133

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 83656978    80 LIAGPAIGG-LAGDISPHLPFVIAAILNACTFLMVFFIFKPAVQTEEKPAEQKQESAGISFITLLNP 145
Cdd:pfam07690 134 AALGPLLGGlLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRD 200
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
3-124 4.30e-05

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 41.83  E-value: 4.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978    3 SDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATGAVAASVVADSTAVSERTAWFGRLGAAFGAGLIA 82
Cdd:PRK09874  78 ADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALL 157

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 83656978   83 GPAIGGLAGDISPHLP--FVIAAILNACTFLMVFFI---FKPAVQTE 124
Cdd:PRK09874 158 GPLAGGLLADSYGLRPvfFITASVLFLCFLVTLFCIrenFQPVSKKE 204
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 1-146 7.94e-04

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 38.13  E-value: 7.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978     1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATGAVAA-SVVADSTAVSERTAWFGRLGAAFGAG 79
Cdd:TIGR00710  62 PLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISqALVRDIYPGEELSRIYSILMPVLALA 141

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 83656978    80 LIAGPAIGGLAGD-ISPHLPFVIAAILNACTFLMVFFIFKpavqtEEKPAEQKQeSAGISFITLLNPL 146
Cdd:TIGR00710 142 PAVAPLLGGYILVwLSWHAIFAFLSLAGILLSALIFFILP-----ETLPYEARI-QISTYFETFLLLL 203
 
Name Accession Description Interval E-value
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 1-129 4.75e-51

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 166.66  E-value: 4.75e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATGAVAASVVADSTAVSERTAWFGRLGAAFGAGL 80
Cdd:cd17388  60 ALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGF 139

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 83656978  81 IAGPAIGGLAGDISPHLPFVIAAILNACTFLMVFFIFKPAVQTEEKPAE 129
Cdd:cd17388 140 IAGPALGGLLGEISPRAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAF 188
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 1-119 4.50e-28

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 105.74  E-value: 4.50e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATGAVAASVVADSTAVSERTAWFGRLGAAFGAGL 80
Cdd:cd17330  56 RLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGF 135

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 83656978  81 IAGPAIGGLAGDISPH-LPFVIAAILNACTFLMVFFIFKP 119
Cdd:cd17330 136 ILGPALGGFLSTPYGYaLPFLVAAALALLNLVLVLFFLPP 175
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 1-118 2.66e-21

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 87.67  E-value: 2.66e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATGAVAASVVADSTAVSERTAWFGRLGAAFGAGL 80
Cdd:cd17390  53 SWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGF 132

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 83656978  81 IAGPAIGGLAGDISPH--LPFVIAAILNACTFLMVFFIFK 118
Cdd:cd17390 133 ILGPVVGGHLAETDGGfyYVALLCSAIFILNAGLVWFLLS 172
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 1-142 5.38e-19

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 81.50  E-value: 5.38e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISgITGATGAVAASVVADSTAVSERTAWFGRLGAAFGAGL 80
Cdd:cd17331  57 RFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLPS-VFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGM 135

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 83656978  81 IAGPAIGG-LAGDISPHLPFVIAAILNACTFLMVfFIFKPAVQTEEKPAEQKQESAGISFITL 142
Cdd:cd17331 136 VVGSFLGGlLTKKFGEQAAALVAAVGSLLSIVLV-ILLIPSNTKSKREKEAKESASPPSVFNL 197
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-146 6.31e-15

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 69.91  E-value: 6.31e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGI-TGATGAVAASVVADSTAVSERTAWFGRLGAAFGAG 79
Cdd:cd17325  53 RLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLaSAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLG 132

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 83656978  80 LIAGPAIGGLAGD-ISPHLPFVIAAILNACTFLMVFFIFKPAVQTEEKPAEQKQESAGISFITLLNPL 146
Cdd:cd17325 133 FLIGPLLGGLLADaLGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRR 200
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 3-117 5.79e-14

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 67.30  E-value: 5.79e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   3 SDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATGAVAASVVADSTAVSERTAWFGRLGAAFGAGLIA 82
Cdd:cd17389  88 SDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVAFSLGFII 167

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 83656978  83 GPAIGG---LAGDISPHLPFVIAAILnACTFLMVFFIF 117
Cdd:cd17389 168 GPMIGAyfaSFTRSLGEVFFSMPALF-ALVLALADLLF 204
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-118 8.73e-13

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 63.84  E-value: 8.73e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGI-TGATGAVAASVVADSTAVSERTAWFGRLGAAFGAG 79
Cdd:COG2814  67 RLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLgAGALFPAALALIADLVPPERRGRALGLLGAGLGLG 146

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 83656978  80 LIAGPAIGGLAGD-ISPHLPFVIAAILNACTFLMVFFIFK 118
Cdd:COG2814 147 PALGPLLGGLLADlFGWRWVFLVNAVLALLALLLLLRLLP 186
MFS_1 pfam07690
Major Facilitator Superfamily;
1-145 1.91e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 62.82  E-value: 1.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978     1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATG-AVAASVVADSTAVSERTAWFGRLGAAFGAG 79
Cdd:pfam07690  54 RLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALfPAALALIADWFPPEERGRALGLVSAGFGLG 133

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 83656978    80 LIAGPAIGG-LAGDISPHLPFVIAAILNACTFLMVFFIFKPAVQTEEKPAEQKQESAGISFITLLNP 145
Cdd:pfam07690 134 AALGPLLGGlLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRD 200
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 1-119 7.93e-12

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 61.47  E-value: 7.93e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATGAVAAS-VVADSTAVSERTAWFGRLGAAFGAG 79
Cdd:cd17329  57 RLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEaMIADVTTPENRTRAFSLLYWAINLG 136

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 83656978  80 LIAGPAIGGLAGDISPHLPFVIAAILNACTFLMVFFIFKP 119
Cdd:cd17329 137 VAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPE 176
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 3-131 2.58e-11

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 59.89  E-value: 2.58e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   3 SDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGI-TGATGAVAASVVADSTAVSERTAWFGRLGAAFGAGLI 81
Cdd:cd17474  58 ADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIgAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIA 137

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 83656978  82 AGPAIGGLAGDISPHLPFVIAAILNACTFLMVFFIFKPAVQTEEKPAEQK 131
Cdd:cd17474 138 VGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATK 187
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-117 4.39e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 59.13  E-value: 4.39e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGI-TGATGAVAASVVADSTAVSERTAWFGRLGAAFGAG 79
Cdd:cd17325 257 KLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLgLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLG 336

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 83656978  80 LIAGPAIGG-LAGDISPHLPFVIAAILNACTFLMVFFIF 117
Cdd:cd17325 337 MVLGPLLGGfLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 1-114 9.60e-11

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 58.32  E-value: 9.60e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGI-TGATGAVAASVVADSTAVSERTAWFGRLGAAFGAG 79
Cdd:cd17370 256 RLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLyMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIG 335

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 83656978  80 LIAGPAIGG-LAGDISPHLPFVIAAILNACTFLMVF 114
Cdd:cd17370 336 WLLASLIAGyLWDLISPSAAFLFSAVLALIALLLLL 371
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 2-143 1.62e-10

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 57.61  E-value: 1.62e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   2 WSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGItGATGAVAASVVADSTAVSERTAWFGRLGA----AFG 77
Cdd:cd17472  55 LSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS-GAISSVVMALLADLTREENRTKAMALIGAsigiAFA 133

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 83656978  78 AGLIAGPAIGGLAGdisphLP--FVIAAILNACTFLMVFFIFKpavqtEEKPAEQKQESAGISFITLL 143
Cdd:cd17472 134 ISMVLGPLLAAHLG-----VSglFLITAILSLVSLLILLFFVP-----DPPKIVQISEKEKKKLKKLL 191
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 3-138 7.84e-10

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 55.66  E-value: 7.84e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   3 SDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGI-TGATGAVAASVVADSTAVSERTAWFGRLGAAFGAGLI 81
Cdd:cd17473  59 ADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIgVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGV 138

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 83656978  82 AGPAIGGLAGDISPHLPFVIAAILNACTFLMVFFIFKPAVQTEEKPAEQKQESAGIS 138
Cdd:cd17473 139 VFLLLGGALAEIGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGAATAAALP 195
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 1-121 1.53e-09

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 54.91  E-value: 1.53e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLG-RRPVLLLSLAGAAFDYTLLAL-----SNVLWMLYLGRIISGITGATGAVAASVVADSTAVSERTAWFGRLGA 74
Cdd:cd17326  58 YWSNKTSsVKEPLIVSILIAIVGNILYALaeyfpSNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISA 137

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 83656978  75 AFGAGLIAGPAIGGL-------AGDISPHLPF-------VIAAILNACTFLMVFFIFKPAV 121
Cdd:cd17326 138 AQALGFIVGPALQAAftpigypGYVIGIKLRFnmytapaWLMAILGIINIILILFFFKEVV 198
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 3-118 2.78e-09

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 54.12  E-value: 2.78e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   3 SDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATGAVAA-SVVADSTAVSERTAWFGRLGAAFGAGLI 81
Cdd:cd17320  58 SDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVArAIVRDLYSGAELAKIFSLLMMILAIAPA 137

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 83656978  82 AGPAIGGLAGDI-SPHLPFVIAAILNACTFLMVFFIFK 118
Cdd:cd17320 138 LAPLLGGLLLLFfGWRAIFVFLALLGLLLLLLVLLFLP 175
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 3-119 4.95e-09

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 53.35  E-value: 4.95e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   3 SDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATG-AVAASVVADSTAVSERTAWFGrlgaAFGAGLI 81
Cdd:cd17323  58 SELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPlAIGAGTIADLFTPEERGKAMG----VYSLGPL 133

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 83656978  82 AGPAIGGLAGD-----ISPHLPFVIAAILNACTFLMVFFIFKP 119
Cdd:cd17323 134 LGPALGPIIGGfitqsLGWRWIFWFLAIISGFCLILIFLFLPI 176
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 3-114 8.66e-09

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 52.81  E-value: 8.66e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   3 SDKLGRRPVLLLSLAGAAFDYTLLALSNvlWMLYLGRIISGITGATGAVAASVVADSTAVSERTAWFGRLGAAFGAGLIA 82
Cdd:cd17387  60 SDVWGRKSFLLLTVFFTCAPIPLMRISP--WWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAYGLVSATFAASLVT 137

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 83656978  83 GPAIGGLA----GDISPHLPFVIAAILNACtFLMVF 114
Cdd:cd17387 138 SPALGAYLsesyGDNLVVLVATIVALLDIC-FILLA 172
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
1-134 5.29e-08

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 50.24  E-value: 5.29e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATGAVAASVVADSTAVSERTAWFGRLGAAFGAGL 80
Cdd:COG0738  65 RLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGA 144

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 83656978  81 IAGPAIGGLA----GDISPHLPFVIAAILNACTFLMVFFIFKPAVQTEEKPAEQKQES 134
Cdd:COG0738 145 LLGPLLGGLLillgLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAAS 202
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-144 5.44e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 50.50  E-value: 5.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATGAVAA-SVVADSTAVSERTAWFGRLGAAFGAG 79
Cdd:cd06174  53 LLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVlALIADLFPERERGRALGLLQAFGSVG 132

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 83656978  80 LIAGPAIGGLAGDISP---HLPFVIAAILNA-CTFLMVFFIFKPAVQTEEKPAEQKQESAGISFITLLN 144
Cdd:cd06174 133 GILGPLLGGILASSLGfgwRAVFLIAAALALlAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLK 201
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 2-117 6.06e-08

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 50.24  E-value: 6.06e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   2 WSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGIT-GATGAVAASVVADSTAVSERTAWFGRLGAAFGAGL 80
Cdd:cd17324  57 LSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAhGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGL 136

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 83656978  81 IAGPAIGGLAGD-ISPHLPFVIAAILNACTFLMVFFIF 117
Cdd:cd17324 137 VLGRPLGGLLGQlLGWRAAFLAIAVLALLAALLLWRLL 174
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 1-129 7.03e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 49.90  E-value: 7.03e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGI-TGATGAVAASVVADSTAVSERTAWFGRLGAAFGAG 79
Cdd:cd17489  53 RLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLA 132

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 83656978  80 LIAGPAIGG-LAGDISPHLPFVIAAILNACTFLMVFFI-FKPAVQTEEKPAE 129
Cdd:cd17489 133 MALGPALGLfLYQHLGFAVLFIVAAVLALLALLLVFLVkDPPPVAAEEAEAG 184
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 3-116 1.24e-07

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 49.10  E-value: 1.24e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   3 SDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGAT-GAVAASVVADSTAVSERTAWFGRLGAAFGAGLI 81
Cdd:cd17502  54 SDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGlMSLAFIIIADLVPPRERGKYQGYIGAVFGIASV 133

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 83656978  82 AGPAIGG-LAGDISPH------LPFVIAAILNACTFLMVFFI 116
Cdd:cd17502 134 AGPLIGGaFTDHLSWRwcfyinLPIGGLALALLRTILLSSIF 175
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 1-116 1.34e-07

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 49.04  E-value: 1.34e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATG-AVAASVVADSTAVSERTAWFGRLGAAFGAG 79
Cdd:COG0477  71 RLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLmPGALALIAELFPARERGRALGLWGAAIGLG 150

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 83656978  80 LIAGPAIGG-LAGDISPHLPFVIAAILNACTFLMVFFI 116
Cdd:COG0477 151 LALGPLLGGlLVAALGWRWIFLINAPLGLLALVLRLRL 188
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 1-127 2.16e-07

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 48.41  E-value: 2.16e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLAL-SNVLWMLYLgRIISGITGATGAVAASVVAdSTAVSERTAW-FGRLGAAFGA 78
Cdd:cd17391  58 RLADRYGRKPMLLRASLGMAIVIGLMAFvTNVWQLLIL-RLLQGVFSGYVPNATALIA-SQTPKEKSGWaLGTLSTGVVA 135

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 83656978  79 GLIAGPAIGGLAGDISPHLP--FVIAAILNACTFLMVFFI---FKPAVQTEEKP 127
Cdd:cd17391 136 GTLIGPLLGGFLADLFGIRNvfFITGGLLFLAFLLTLFFVkedFKPVEKKKMVS 189
MFS_SLC46A1_PCFT cd17449
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ...
 2-128 2.55e-07

Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341007 [Multi-domain]  Cd Length: 425  Bit Score: 48.27  E-value: 2.55e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   2 WSDKLGRRPVLLLSLAG----AAFDYTLLALSNVLWMLYLGRIISGITGATGAVAA---SVVADSTAVSERTAWFGRLGA 74
Cdd:cd17449  88 WSDSVGRRPVLILPSLGlalqAAVYLLVMYLQLHVAYFLIGRILSGLLGDFNGILAgcfAYVADVSDRRSRTFRVAVLEA 167

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 83656978  75 AFGAGLIAGPAIGG----LAGDISphlPFVIAAILNACTFLMVFFIFKPAVqTEEKPA 128
Cdd:cd17449 168 CLGLAGMLASIIGGqwrkAQGYIN---PFWLVLALNLAAALYAAFCVGESV-KEPKSA 221
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 2-116 8.25e-07

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 46.83  E-value: 8.25e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   2 WSDKLGRR-PVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATGAVAASVVADSTAVSERTAWFGRLGAAFGAGL 80
Cdd:cd17490  54 LSDRIGKRkLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQ 133

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 83656978  81 IAGPAIGGLAGD-ISPHLPFVIAAILNACTFLMVFFI 116
Cdd:cd17490 134 LIAFLIGGLIAEhFGMRAPFLLAALAGVLGFILSLFI 170
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 1-112 1.45e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 46.06  E-value: 1.45e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGI-TGATGAVAASVVADSTAVSERTAWFGRLGAAFGAG 79
Cdd:cd17316  58 YLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIgIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALG 137

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 83656978  80 LIAGPAIGGLAGDISPH-----LPFVIAAILNACTFLM 112
Cdd:cd17316 138 ALLAALVASLLIPLLSGdwgwrILFLIGALPALLALLL 175
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
1-130 2.50e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 45.64  E-value: 2.50e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATG-AVAASVVADSTAVSERTAWFGRLGAAFGAG 79
Cdd:COG2223  62 FLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSfAVGIALVSKWFPPDRRGLALGLAAGGGNLG 141

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 83656978  80 -LIAGPAIGGLAGDISPHLPFVIAAILNACTFLMVFFIFKPAVQTEEKPAEQ 130
Cdd:COG2223 142 aAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKA 193
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 2-117 3.15e-06

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 45.35  E-value: 3.15e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   2 WSDKLGRRPVLLLSLAGAAFDYTLLALS------NVLWMLYLGRIISGITGATGAVAASV---VADSTAVSERTAWFGRL 72
Cdd:cd17386  53 WSDRYGRKPPLLMSLVGLLLSSLILVLIvyfttvPSVWWFYLSAIPLALFGGFTAFLSASfayISDISSEKKRTYRMAIL 132

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 83656978  73 GAAFGAGLIAGPAIGG-LAGDISPHLPF-VIAAILNACTFLMVFFIF 117
Cdd:cd17386 133 EVALGLGGFLGSLLSGhLFKALGYAWSFsISAALLLIALLYILFFLT 179
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-117 5.58e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 44.48  E-value: 5.58e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGI-TGATGAVAASVVADSTAVSERTAWFGRLGAAFGAG 79
Cdd:COG2271  67 LLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLgEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLG 146

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 83656978  80 LIAGPAIGG-LAGDISPHLPFVIAAILNACTFLMVFFIF 117
Cdd:COG2271 147 GALAPPLLGwLLAAFGWRAAFLILGLPGLLLALLRFWLL 185
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 3-89 1.20e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 43.70  E-value: 1.20e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   3 SDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGA-TGAVAASVVADSTAVSERTAWFGRLGAAFGAGLI 81
Cdd:cd17321  55 GDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAaIMPASLALIAATFPGERRGRALGLWGAVVGIGAA 134


                ....*...
gi 83656978  82 AGPAIGGL 89
Cdd:cd17321 135 LGPLLGGL 142
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
3-124 4.30e-05

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 41.83  E-value: 4.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978    3 SDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATGAVAASVVADSTAVSERTAWFGRLGAAFGAGLIA 82
Cdd:PRK09874  78 ADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALL 157

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 83656978   83 GPAIGGLAGDISPHLP--FVIAAILNACTFLMVFFI---FKPAVQTE 124
Cdd:PRK09874 158 GPLAGGLLADSYGLRPvfFITASVLFLCFLVTLFCIrenFQPVSKKE 204
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 4-116 6.31e-05

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 41.41  E-value: 6.31e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   4 DKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGIT-GATGAVAASVVADSTAVSERtawfGRLGAAFGAGLIA 82
Cdd:cd17358  66 DRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGgGAASVVVPVYIAEIAPKNVR----GALGSLNQLLVNI 141

                        90       100       110
                ....*....|....*....|....*....|....*
gi 83656978  83 GPAIGGLAGD-ISPHLPFVIAAILNACTFLMVFFI 116
Cdd:cd17358 142 GILLGYVLGSfLPWRTLALIGAIPPVVFLILLFFI 176
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 1-128 6.89e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 41.39  E-value: 6.89e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATGAVAA-SVVADSTAVSERTAWFGRLGAAFGAG 79
Cdd:cd17477  53 RLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSeSWLNALATNENRGRVLGLYSTVLGLG 132

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 83656978  80 LIAGPAIGGLAGdISPHLPFVIAAILNACTFLMVFFIFKPAVQTEEKPA 128
Cdd:cd17477 133 FALGPLLLALVG-TAGALPFLIAAVLLLLALVPLLLTRRAAPEIEEAES 180
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 2-116 1.78e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 40.25  E-value: 1.78e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   2 WSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATGA-VAASVVADSTAVSERTAWFGRLGAAFGAGL 80
Cdd:cd17503  54 LADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIpLAQTILLRIYPPEKRGAAMGLVGLVILLAP 133

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 83656978  81 IAGPAIGG-LAGDISPHLPFVIAAILNACTFLMVFFI 116
Cdd:cd17503 134 AIGPTLGGwLTDNLSWRWIFYINLPIGILALLLAPLL 170
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 1-115 2.01e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.88  E-value: 2.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATGAVAASVVA-DSTAVSERTAWFGRLGAAFGAG 79
Cdd:cd17489 249 KLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAvDLVPPHRRGAANGTFFIFFDLG 328

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 83656978  80 LIAGPAIGG-LAGDISPHLPFVIAAILNACTFLMVFF 115
Cdd:cd17489 329 IGLGGLLLGlVAELFGYRAMFLLAAVVVLLALVLYIF 365
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
1-125 5.11e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 38.71  E-value: 5.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALS--NVLWMLYLGRIISGITGATGAVAASVVADSTAVSERTAWFGRLGAAFGA 78
Cdd:COG2223 263 WLSDRIGGRRVLLIVFALMALGLLLLALAlgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGL 342

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 83656978  79 GLIAGPAIGGLAGDI--SPHLPFVIAAILNACTFLMVFFIFKPAVQTEE 125
Cdd:COG2223 343 GGFLGPLLFGALLDAtgSYTAAFLVFAVLALVALVLTLLLYRRPRRAAA 391
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 1-114 5.61e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 38.69  E-value: 5.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLL-SLAGAAFDYTLLALSNVLWMLY-LGRIISGITGATGAVAASVVADSTAVSERTAWFGRLGAAFGA 78
Cdd:cd17477 245 WLADRFDRRRVLLGcALLGALAALLLPLVPGLPLALLvLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGL 324

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 83656978  79 GLIAGPAIGGLAGDISPHLPFVIAAILNACTFLMVF 114
Cdd:cd17477 325 GSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 1-146 7.94e-04

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 38.13  E-value: 7.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978     1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATGAVAA-SVVADSTAVSERTAWFGRLGAAFGAG 79
Cdd:TIGR00710  62 PLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISqALVRDIYPGEELSRIYSILMPVLALA 141

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 83656978    80 LIAGPAIGGLAGD-ISPHLPFVIAAILNACTFLMVFFIFKpavqtEEKPAEQKQeSAGISFITLLNPL 146
Cdd:TIGR00710 142 PAVAPLLGGYILVwLSWHAIFAFLSLAGILLSALIFFILP-----ETLPYEARI-QISTYFETFLLLL 203
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 1-116 8.40e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 38.33  E-value: 8.40e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATGAVAASVVADSTAVSERTAWFGRLGAAFGAGL 80
Cdd:cd17504  53 RLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGA 132

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 83656978  81 IAGPAIGG-LAGDISPHLPFVIAAILNACTFLMVFFI 116
Cdd:cd17504 133 GIGLPLGGwIVQHLGWRWIFWTAAPVAVLLAALVPLI 169
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 1-117 1.26e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 37.57  E-value: 1.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGI-TGATGAVAASVVADSTAVSERTAW---------FG 70
Cdd:cd17365  56 PLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLgLGAAMPNAITLVSEYAPARRRSLAvtlmfcgypLG 135

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 83656978  71 RLGAAFGAGLIAGP-------AIGGLAGDISphLPFVIAAILNACTFLMVFFIF 117
Cdd:cd17365 136 AALGGFLAAALIPAfgwrsvfLLGGVPPLIL--LPLLRGTLLLWVTFFMGLLLV 187
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 1-105 1.27e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 37.54  E-value: 1.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATGAVAASVVADSTAVSERTAWFGRLGAAFGAGL 80
Cdd:cd17478 252 PLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGLMMGLSFGLGG 331

                        90       100
                ....*....|....*....|....*
gi 83656978  81 IAGPAIGGLAGDISPHLPFVIAAIL 105
Cdd:cd17478 332 IGAPVLGALADAFGLESVLLILALL 356
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 3-120 1.81e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 37.30  E-value: 1.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   3 SDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATGAVAASVVADSTAVSERTAWFGRLGAAFGAGLIA 82
Cdd:cd17333  55 MKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALI 134

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 83656978  83 GPAIGGLAGDISP--HLPFVIAAILNACTFLMVFFIFKPA 120
Cdd:cd17333 135 GPLIATSLLTSELswSWAYLIIGLIYLLLAILILLTLFPE 174
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 1-116 1.94e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 37.21  E-value: 1.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATGAVAA-SVVADSTAVSERTAWFGRLGAAFGAG 79
Cdd:cd06173 266 RLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLnTLLQLRVPDELRGRVFSVYNALNSGA 345

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 83656978  80 LIAGPAIGGLAGD-ISPHLPFVIAAILNACTFLMVFFI 116
Cdd:cd06173 346 MPLGALLAGLLADaLGLSAVFLLAGALLLLAALLLLLL 383
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 3-116 2.78e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 36.82  E-value: 2.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   3 SDKLGRRPVLLLSLA-GAAFDYTLLALSNVLWMLYLGRIISGIT-GATGAVAASVVADSTAVSERTAWFGRLGAAFGAGL 80
Cdd:cd17353 273 SDKIGRKNTLSIAFLiQGVAMFLLPFIGSVAVLFVLGVALIGFCyGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGG 352

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 83656978  81 IAGPAIGG-LAGDISPHLPFVIAAILNACTFLMVFFI 116
Cdd:cd17353 353 LIGPIIAAyVLYTGGYNAAFIIAAALSLVALALALLL 389
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
1-90 3.74e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 36.42  E-value: 3.74e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNV--LWMLYLGRIISGIT-GATGAVAASVVADSTAVSERTAWFGRLGAAFG 77
Cdd:COG2211 286 RLAKRFGKKKAFIIGLLLAALGLLLLFFLGPgnLWLLLVLAALAGIGlGAILVLPWAMLADVVDYDEWKTGRRREGLYFG 365

                        90       100
                ....*....|....*....|
gi 83656978  78 A-------GLIAGPAIGGLA 90
Cdd:COG2211 366 IftfaiklGQALAGALAGLL 385
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 1-117 4.53e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 36.09  E-value: 4.53e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGI-TGATGAVAASVVADSTAVSERTAWFGRLGAAFGAG 79
Cdd:cd17391 262 KLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLaTGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLG 341

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 83656978  80 LIAGPAIGG-LAGDISPHLPFVIAAILNACTFLMVFFIF 117
Cdd:cd17391 342 NVAGPLLGSaIAAHFGYRAVFVVTALLVLLNAIWSFIFL 380
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 1-116 4.95e-03

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 36.02  E-value: 4.95e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGIT-GATGAVAASVVADSTAVSERTAWFGRLGAA-FGA 78
Cdd:cd17335 255 RLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTfALVWAAAVSYASAAAPPGLRATAQGLLQGLyFGL 334

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 83656978  79 GLIAGPAIGG-LAGDISPHLPFVIAAILNACTFLMVFFI 116
Cdd:cd17335 335 GGGLGSLIGGyLYEAFGARTTFRFFAIAALAGLLAFFLI 373
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 3-55 5.59e-03

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 35.96  E-value: 5.59e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 83656978   3 SDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGatGAVAASV 55
Cdd:cd17434  65 NDRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLLGRFLTGFAG--GITAASI 115
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 2-146 6.06e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 35.67  E-value: 6.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   2 WSDKLGRRPVLLLSLAG-----AAFDYTLLALSNVLWMLYLGRIISGITGATGAVAA-SVVADSTAVSERTAWFGRLGAA 75
Cdd:cd06173  57 LADRFDRRRLLILADLLrallaAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARqALLPELVPKEQLVRANALNSLA 136

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 83656978  76 FGAGLIAGPAIGG-LAGDISPHLPFVIAAILNACTFLMVFFI-FKPAVQTEEKPAEQKQESAGISFITLLNPL 146
Cdd:cd06173 137 TQLARIIGPALGGlLVALLGPGGAFAINALSFLLSALLLLFIrRPPPAAPGESSSLLLRDLREGLRYLRRSPL 209
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 1-119 6.57e-03

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 35.68  E-value: 6.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVL----LLSLAGAAfdytLLALSNVLWMLYLGRIISGITGATGAVAASVVADSTAVSERTAWFGRLGAAF 76
Cdd:cd06179  54 RLSDLFGRRWFFiggnLLGVVGSI----VAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVA 129

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 83656978  77 GAGLIAGPAIGGL---AGDISPHLPFVIAAILNACTFLMVFFIFKP 119
Cdd:cd06179 130 SPGSALGPLIAGAlveANAAGWRWIFYINAIFNALALILLFFFYHP 175
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 1-114 7.20e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 35.60  E-value: 7.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   1 RWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGIT-GATGAVAASVVADSTAvsertawfGRLGAA---- 75
Cdd:cd17471 257 LLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFiGITAGLGISYFQDLMP--------GQPGLAttly 328

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 83656978  76 ---FGAG-LIAGPAIGGLAGDISPHLPFVIAAILNACTFLMVF 114
Cdd:cd17471 329 snaSRIGsLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 3-115 8.58e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 35.24  E-value: 8.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83656978   3 SDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGItgatgAVAASVVADSTAVSE--RTAWFGRLGAAFG--- 77
Cdd:cd17315  58 ADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGL-----GVGLASVLVPLYISEiaPAKIRGALGTLNQlmi 132

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 83656978  78 -AGLIAGPAIGGLAGDISPH---LPFVIAAILNACTFLMVFF 115
Cdd:cd17315 133 tFGILLAYLLGLALSLSPPGwwrLMFALAAVPALLQLLLMFF 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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