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Conserved domains on  [gi|84181563|gb|ABC55166|]
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hypothetical protein [Cyprinid herpesvirus 3]

Protein Classification

PHA03369 family protein( domain architecture ID 11476221)

PHA03369 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03369 PHA03369
capsid maturational protease; Provisional
 1-737 0e+00

capsid maturational protease; Provisional


:

Pssm-ID: 223061 [Multi-domain]  Cd Length: 663  Bit Score: 684.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563    1 MAPHLRSRSLTARHLTESRTEGLSFHGQRPDGTILAVDRGRLLCTHADIDELERTLLGSSAPVSHKDLVPIYCDRCLPYT 80
Cdd:PHA03369   1 TQPPRRSMSLGAGRRTEKIETGESVYVKRPDGTTGAYDTGSFLNVSCQEDEAEADTLPSLTPRSDEHFVPVFCDRCFGTT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563   81 LP-WSQAPVSHDRDGLlpahGYTVVGTAGVFSRDLVE----------TKGMEKTSQHYHLPLRDLELFTHTqKSNRVLLV 149
Cdd:PHA03369  81 LEeYELVRFGISADQS----GYYVVGTAGVFSPGDPVdpslypstsaGDMDPEHMRKYHLPRENAEYMVHV-APGRLLYS 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  150 HCDIPIGSVICYWHVHdrENAHCAVNALIVITDQA-----FHTIFSRCKGLSWTTTSV----VASELSLVGIPGRASSLI 220
Cdd:PHA03369 156 HKGIPIGKVLCYWHVH--ENDRCGVNALVGIDNSEdtgkrCVETFTEACGLSWTTLDVglndVIVELSAVVIPARRGCLA 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  221 HSISRLSDLTQGtlpvsrkpdLRSLGYGRNSPRHADVVMAALS----------KGTENPEETASDQRREWKQMVEMLMGQ 290
Cdd:PHA03369 234 KLFTRATVSDGL---------LEKFGFGSNVLRQGEAPLNALLeilkaknaemPGTLNPSFGSSDESPEWKTFYEALADQ 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  291 LDLLYEATIAKGPDDDGQASKRYLSEGRDLFKKLHELKAHLEKLESASTPAAVSAAAPAPSTSVPAPQQTTETPKEDSRA 370
Cdd:PHA03369 305 LNNLYKLLRTIYKHKDETVIEQYLIEGRKLFSTINGLKAHNEILKTASLTAPSRVLAAAAKVAVIAAPQTHTGPADRQRP 384

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  371 GTPEASVTSQQAQSAPVPSQPVTSVPSQPVTSVPSQPVtsvpsQPVTSVPSQPVTSVPSQPVTSVQQPNKMASsddirda 450
Cdd:PHA03369 385 QRPDGIPYSVPARSPMTAYPPVPQFCGDPGLVSPYNPQ-----SPGTSYGPEPVGPVPPQPTNPYVMPISMAN------- 452

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  451 vakaladvikpsiqqytpppqpnhgggatgfrdfvemfklmqqmhapaqapapvaapapvvaqvpqslshhgLVDDEHPS 530
Cdd:PHA03369 453 ------------------------------------------------------------------------MVYPGHPQ 460

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  531 TSAHQRGGKRKLELSDDDI---KLFKKLREQDELSRREKERLALKEELKKEMMAEFSSSVPQAAAPVVVPSTSAPAPVTD 607
Cdd:PHA03369 461 EHGHERKRKRGGELKEELIetlKLVKKLKEEQESLAKELEATAHKSEIKKIAESEFKNAGAKTAAANIEPNCSADAAAPA 540

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  608 VKQLVSEAIKELLavqqqqQQQAVVPAPQGVPGPATTISLPVATLAAATGRSPAAAAALQSAINNVHESASQlVPGGLNL 687
Cdd:PHA03369 541 TKRARPETKTELE------AVVRFPYQIRNMESPAFVHSFTSTTLAAAAGQGSDTAEALAGAIETLLTQASA-QPAGLSL 613

                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|
gi 84181563  688 GVAGVPVNASTVVSTPQPAVPSTSTQVVSVSAGLEVQGGGNKKSLNDDAR 737
Cdd:PHA03369 614 PAPAVPVNASTPASTPPPLAPQEPPQPGTSAPSLETSLPQQKPVLSKGAF 663
 
Name Accession Description Interval E-value
PHA03369 PHA03369
capsid maturational protease; Provisional
 1-737 0e+00

capsid maturational protease; Provisional


Pssm-ID: 223061 [Multi-domain]  Cd Length: 663  Bit Score: 684.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563    1 MAPHLRSRSLTARHLTESRTEGLSFHGQRPDGTILAVDRGRLLCTHADIDELERTLLGSSAPVSHKDLVPIYCDRCLPYT 80
Cdd:PHA03369   1 TQPPRRSMSLGAGRRTEKIETGESVYVKRPDGTTGAYDTGSFLNVSCQEDEAEADTLPSLTPRSDEHFVPVFCDRCFGTT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563   81 LP-WSQAPVSHDRDGLlpahGYTVVGTAGVFSRDLVE----------TKGMEKTSQHYHLPLRDLELFTHTqKSNRVLLV 149
Cdd:PHA03369  81 LEeYELVRFGISADQS----GYYVVGTAGVFSPGDPVdpslypstsaGDMDPEHMRKYHLPRENAEYMVHV-APGRLLYS 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  150 HCDIPIGSVICYWHVHdrENAHCAVNALIVITDQA-----FHTIFSRCKGLSWTTTSV----VASELSLVGIPGRASSLI 220
Cdd:PHA03369 156 HKGIPIGKVLCYWHVH--ENDRCGVNALVGIDNSEdtgkrCVETFTEACGLSWTTLDVglndVIVELSAVVIPARRGCLA 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  221 HSISRLSDLTQGtlpvsrkpdLRSLGYGRNSPRHADVVMAALS----------KGTENPEETASDQRREWKQMVEMLMGQ 290
Cdd:PHA03369 234 KLFTRATVSDGL---------LEKFGFGSNVLRQGEAPLNALLeilkaknaemPGTLNPSFGSSDESPEWKTFYEALADQ 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  291 LDLLYEATIAKGPDDDGQASKRYLSEGRDLFKKLHELKAHLEKLESASTPAAVSAAAPAPSTSVPAPQQTTETPKEDSRA 370
Cdd:PHA03369 305 LNNLYKLLRTIYKHKDETVIEQYLIEGRKLFSTINGLKAHNEILKTASLTAPSRVLAAAAKVAVIAAPQTHTGPADRQRP 384

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  371 GTPEASVTSQQAQSAPVPSQPVTSVPSQPVTSVPSQPVtsvpsQPVTSVPSQPVTSVPSQPVTSVQQPNKMASsddirda 450
Cdd:PHA03369 385 QRPDGIPYSVPARSPMTAYPPVPQFCGDPGLVSPYNPQ-----SPGTSYGPEPVGPVPPQPTNPYVMPISMAN------- 452

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  451 vakaladvikpsiqqytpppqpnhgggatgfrdfvemfklmqqmhapaqapapvaapapvvaqvpqslshhgLVDDEHPS 530
Cdd:PHA03369 453 ------------------------------------------------------------------------MVYPGHPQ 460

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  531 TSAHQRGGKRKLELSDDDI---KLFKKLREQDELSRREKERLALKEELKKEMMAEFSSSVPQAAAPVVVPSTSAPAPVTD 607
Cdd:PHA03369 461 EHGHERKRKRGGELKEELIetlKLVKKLKEEQESLAKELEATAHKSEIKKIAESEFKNAGAKTAAANIEPNCSADAAAPA 540

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  608 VKQLVSEAIKELLavqqqqQQQAVVPAPQGVPGPATTISLPVATLAAATGRSPAAAAALQSAINNVHESASQlVPGGLNL 687
Cdd:PHA03369 541 TKRARPETKTELE------AVVRFPYQIRNMESPAFVHSFTSTTLAAAAGQGSDTAEALAGAIETLLTQASA-QPAGLSL 613

                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|
gi 84181563  688 GVAGVPVNASTVVSTPQPAVPSTSTQVVSVSAGLEVQGGGNKKSLNDDAR 737
Cdd:PHA03369 614 PAPAVPVNASTPASTPPPLAPQEPPQPGTSAPSLETSLPQQKPVLSKGAF 663
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 360-444 6.38e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 43.02  E-value: 6.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563   360 TTETPKEDSRAGTPEASVTSQQAQSAPVPSQPVTSVPSQPVTSVP---SQPVTSVPSQPVTSVPSQPVTSVPSQPVTSVQ 436
Cdd:pfam17823  87 TAEHTPHGTDLSEPATREGAADGAASRALAAAASSSPSSAAQSLPaaiAALPSEAFSAPRAAACRANASAAPRAAIAAAS 166


                  ....*...
gi 84181563   437 QPNKMASS 444
Cdd:pfam17823 167 APHAASPA 174
SP2_N cd22540
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins ...
 353-448 1.18e-03

N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP2 contains the least conserved DNA-binding domain within the SP subfamily of proteins, and its DNA sequence specificity differs from the other SP proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate, or in some cases, repress expression from different promoters. The transcription factor SP2 serves as a paradigm for indirect genomic binding. It does not require its DNA-binding domain for genomic DNA binding and occupies target promoters independently of whether they contain a cognate DNA-binding motif. SP2 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP2.


Pssm-ID: 411776 [Multi-domain]  Cd Length: 511  Bit Score: 42.22  E-value: 1.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563 353 SVPAPQQTTETPKEDSRAGTPEASVTSQQAQSA---PVPSQPVTSVPSQPVTSVPSQPVTSVPSQPVTSVPSQ--PVTSV 427
Cdd:cd22540 284 AVLQQVQVLQPKQEQQVVQIPQQALRVVQAASAtlpTVPQKPLQNIQIQNSEPTPTQVYIKTPSGEVQTVLLQeaPAATA 363

                        90       100
                ....*....|....*....|.
gi 84181563 428 PSQPVTSVQQPNKMASSDDIR 448
Cdd:cd22540 364 TPSSSTSTVQQQVTANNGTGT 384
 
Name Accession Description Interval E-value
PHA03369 PHA03369
capsid maturational protease; Provisional
 1-737 0e+00

capsid maturational protease; Provisional


Pssm-ID: 223061 [Multi-domain]  Cd Length: 663  Bit Score: 684.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563    1 MAPHLRSRSLTARHLTESRTEGLSFHGQRPDGTILAVDRGRLLCTHADIDELERTLLGSSAPVSHKDLVPIYCDRCLPYT 80
Cdd:PHA03369   1 TQPPRRSMSLGAGRRTEKIETGESVYVKRPDGTTGAYDTGSFLNVSCQEDEAEADTLPSLTPRSDEHFVPVFCDRCFGTT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563   81 LP-WSQAPVSHDRDGLlpahGYTVVGTAGVFSRDLVE----------TKGMEKTSQHYHLPLRDLELFTHTqKSNRVLLV 149
Cdd:PHA03369  81 LEeYELVRFGISADQS----GYYVVGTAGVFSPGDPVdpslypstsaGDMDPEHMRKYHLPRENAEYMVHV-APGRLLYS 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  150 HCDIPIGSVICYWHVHdrENAHCAVNALIVITDQA-----FHTIFSRCKGLSWTTTSV----VASELSLVGIPGRASSLI 220
Cdd:PHA03369 156 HKGIPIGKVLCYWHVH--ENDRCGVNALVGIDNSEdtgkrCVETFTEACGLSWTTLDVglndVIVELSAVVIPARRGCLA 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  221 HSISRLSDLTQGtlpvsrkpdLRSLGYGRNSPRHADVVMAALS----------KGTENPEETASDQRREWKQMVEMLMGQ 290
Cdd:PHA03369 234 KLFTRATVSDGL---------LEKFGFGSNVLRQGEAPLNALLeilkaknaemPGTLNPSFGSSDESPEWKTFYEALADQ 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  291 LDLLYEATIAKGPDDDGQASKRYLSEGRDLFKKLHELKAHLEKLESASTPAAVSAAAPAPSTSVPAPQQTTETPKEDSRA 370
Cdd:PHA03369 305 LNNLYKLLRTIYKHKDETVIEQYLIEGRKLFSTINGLKAHNEILKTASLTAPSRVLAAAAKVAVIAAPQTHTGPADRQRP 384

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  371 GTPEASVTSQQAQSAPVPSQPVTSVPSQPVTSVPSQPVtsvpsQPVTSVPSQPVTSVPSQPVTSVQQPNKMASsddirda 450
Cdd:PHA03369 385 QRPDGIPYSVPARSPMTAYPPVPQFCGDPGLVSPYNPQ-----SPGTSYGPEPVGPVPPQPTNPYVMPISMAN------- 452

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  451 vakaladvikpsiqqytpppqpnhgggatgfrdfvemfklmqqmhapaqapapvaapapvvaqvpqslshhgLVDDEHPS 530
Cdd:PHA03369 453 ------------------------------------------------------------------------MVYPGHPQ 460

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  531 TSAHQRGGKRKLELSDDDI---KLFKKLREQDELSRREKERLALKEELKKEMMAEFSSSVPQAAAPVVVPSTSAPAPVTD 607
Cdd:PHA03369 461 EHGHERKRKRGGELKEELIetlKLVKKLKEEQESLAKELEATAHKSEIKKIAESEFKNAGAKTAAANIEPNCSADAAAPA 540

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  608 VKQLVSEAIKELLavqqqqQQQAVVPAPQGVPGPATTISLPVATLAAATGRSPAAAAALQSAINNVHESASQlVPGGLNL 687
Cdd:PHA03369 541 TKRARPETKTELE------AVVRFPYQIRNMESPAFVHSFTSTTLAAAAGQGSDTAEALAGAIETLLTQASA-QPAGLSL 613

                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|
gi 84181563  688 GVAGVPVNASTVVSTPQPAVPSTSTQVVSVSAGLEVQGGGNKKSLNDDAR 737
Cdd:PHA03369 614 PAPAVPVNASTPASTPPPLAPQEPPQPGTSAPSLETSLPQQKPVLSKGAF 663
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 356-470 1.14e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.85  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563   356 APQQTTETPKEdsragtPEASVTSQQAQSAPVPSQPVTSVPSQPVTsvpSQPVTSVPSQPVTSVP--SQPVTSVPSQPVT 433
Cdd:PRK10263  773 APQPQYQQPQQ------PVAPQPQYQQPQQPVAPQPQYQQPQQPVA---PQPQYQQPQQPVAPQPqyQQPQQPVAPQPQD 843

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 84181563   434 SVQQPNKMASSDDirDAVAKALADVikPSIQQYTPPP 470
Cdd:PRK10263  844 TLLHPLLMRNGDS--RPLHKPTTPL--PSLDLLTPPP 876
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 353-454 1.40e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 45.24  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  353 SVPAPQQTTETPKEDSRAGTPEASVTSQQAQSAPVPSQPVTSVPSQPVTSVPSQPVTSVPSQ------PVTSVPSQPVTS 426
Cdd:PRK07994 367 EPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQlqraqgATKAKKSEPAAA 446

                         90       100
                 ....*....|....*....|....*...
gi 84181563  427 VPSQPVTSVQQPnkMASSDDIRDAVAKA 454
Cdd:PRK07994 447 SRARPVNSALER--LASVRPAPSALEKA 472
PRK13335 PRK13335
superantigen-like protein SSL3; Reviewed;
352-469 2.76e-04

superantigen-like protein SSL3; Reviewed;


Pssm-ID: 139494 [Multi-domain]  Cd Length: 356  Bit Score: 43.96  E-value: 2.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  352 TSVPAPQQTTETPKEDSRAGTPEASVTSQQAQSAPVPSQPVTSVPSQPVTSVPSQpvtsvpSQPVTSVPS-QPVTSVPSQ 430
Cdd:PRK13335  62 TTQAANTRQERTPKLEKAPNTNEEKTSASKIEKISQPKQEEQKSLNISATPAPKQ------EQSQTTTEStTPKTKVTTP 135

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 84181563  431 PVTSVQQPNKMASSDDIRDAVAKALADVIKPSIQQ----YTPP 469
Cdd:PRK13335 136 PSTNTPQPMQSTKSDTPQSPTIKQAQTDMTPKYEDlrayYTKP 178
PRK12757 PRK12757
cell division protein FtsN; Provisional
 357-431 3.18e-04

cell division protein FtsN; Provisional


Pssm-ID: 237191 [Multi-domain]  Cd Length: 256  Bit Score: 43.11  E-value: 3.18e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 84181563  357 PQQTTETPKEDSRAGTPEASVTSQQAQSAPVPsqPVTSVPSQPVT--SVPSQPVTSVPSQPVTSVPSQPVTSVPSQP 431
Cdd:PRK12757  99 PTQLSEVPYNEQTPQVPRSTVQIQQQAQQQQP--PATTAQPQPVTppRQTTAPVQPQTPAPVRTQPAAPVTQAVEAP 173
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 360-444 6.38e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 43.02  E-value: 6.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563   360 TTETPKEDSRAGTPEASVTSQQAQSAPVPSQPVTSVPSQPVTSVP---SQPVTSVPSQPVTSVPSQPVTSVPSQPVTSVQ 436
Cdd:pfam17823  87 TAEHTPHGTDLSEPATREGAADGAASRALAAAASSSPSSAAQSLPaaiAALPSEAFSAPRAAACRANASAAPRAAIAAAS 166


                  ....*...
gi 84181563   437 QPNKMASS 444
Cdd:pfam17823 167 APHAASPA 174
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 357-470 8.20e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.15  E-value: 8.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563   357 PQQTTETPKEDSRAGTPEASVTSQQAQSAPVPSQPVTSVPSQPVTSVP--SQPVTSVPSQPVTSV------------PSQ 422
Cdd:PRK10263  781 PQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPqyQQPQQPVAPQPQDTLlhpllmrngdsrPLH 860

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 84181563   423 -PVTSVPS----QPVTSVQQPNKMASSDDIRDAVAKALADV-IKPSIQQYTPPP 470
Cdd:PRK10263  861 kPTTPLPSldllTPPPSEVEPVDTFALEQMARLVEARLADFrIKADVVNYSPGP 914
SP2_N cd22540
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins ...
 353-448 1.18e-03

N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP2 contains the least conserved DNA-binding domain within the SP subfamily of proteins, and its DNA sequence specificity differs from the other SP proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate, or in some cases, repress expression from different promoters. The transcription factor SP2 serves as a paradigm for indirect genomic binding. It does not require its DNA-binding domain for genomic DNA binding and occupies target promoters independently of whether they contain a cognate DNA-binding motif. SP2 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP2.


Pssm-ID: 411776 [Multi-domain]  Cd Length: 511  Bit Score: 42.22  E-value: 1.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563 353 SVPAPQQTTETPKEDSRAGTPEASVTSQQAQSA---PVPSQPVTSVPSQPVTSVPSQPVTSVPSQPVTSVPSQ--PVTSV 427
Cdd:cd22540 284 AVLQQVQVLQPKQEQQVVQIPQQALRVVQAASAtlpTVPQKPLQNIQIQNSEPTPTQVYIKTPSGEVQTVLLQeaPAATA 363

                        90       100
                ....*....|....*....|.
gi 84181563 428 PSQPVTSVQQPNKMASSDDIR 448
Cdd:cd22540 364 TPSSSTSTVQQQVTANNGTGT 384
PRK12757 PRK12757
cell division protein FtsN; Provisional
 355-423 1.64e-03

cell division protein FtsN; Provisional


Pssm-ID: 237191 [Multi-domain]  Cd Length: 256  Bit Score: 40.80  E-value: 1.64e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 84181563  355 PAPQQTTETPKEDSRAGTPEAsvtsQQAQSAPVPSQPVTSVPSQPVTSVPSQPVTSVPSQPVTSVPSQP 423
Cdd:PRK12757 112 PQVPRSTVQIQQQAQQQQPPA----TTAQPQPVTPPRQTTAPVQPQTPAPVRTQPAAPVTQAVEAPKVE 176
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 353-450 1.70e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.62  E-value: 1.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  353 SVPAPQQTTETPKEDSRAGTPEASVTSQQAqSAPVPSQPVTSVPSQPVTSVPSQPVTSVPSQPVTSVPSQPVTSVPSQPV 432
Cdd:PRK14951 380 TPARPEAAAPAAAPVAQAAAAPAPAAAPAA-AASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPE 458

                         90
                 ....*....|....*...
gi 84181563  433 TsVQQPNKMASSDDIRDA 450
Cdd:PRK14951 459 T-VAIPVRVAPEPAVASA 475
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 357-472 3.78e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.84  E-value: 3.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563   357 PQQTTETP--KEDSRAGTPEASVTSQQAQSAPVPSQPVTSVPSQPVtsvPSQPVTSVPSQPVTSVPSQPVTSVPSQPVTS 434
Cdd:PRK10263  740 PHEPLFTPivEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPV---APQPQYQQPQQPVAPQPQYQQPQQPVAPQPQ 816

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 84181563   435 VQQPNKMASSddirdavakaladviKPSIQQYTPPPQP 472
Cdd:PRK10263  817 YQQPQQPVAP---------------QPQYQQPQQPVAP 839
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 346-454 7.33e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 7.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  346 AAPAPSTSVPAPQQTTETPKEDSRAGTPEASVTSQQAQSAPVPSQPVTSVPSQPVTSVPSQPVTSVPSQPVTSVPSQPVT 425
Cdd:PRK07764 423 PAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAA 502

                         90       100
                 ....*....|....*....|....*....
gi 84181563  426 SVPSQPVTSVQQpnkmaSSDDIRDAVAKA 454
Cdd:PRK07764 503 PAGADDAATLRE-----RWPEILAAVPKR 526
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 355-480 8.23e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 39.63  E-value: 8.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563   355 PAPQQTTETPKEDSRAGTPEASVTSQQAQSAPVPSQPVTSVPSQPVTSVPSQPVTSVP-SQPVTSVPSQPVTSVPSQPVT 433
Cdd:pfam09770 210 PAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQrPQSPQPDPAQPSIQPQAQQFH 289

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 84181563   434 SVQQPNKMASSDDIRDAVAKALADVIKPSIQQYTPPPQPNHGGGATG 480
Cdd:pfam09770 290 QQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQ 336
PHA02030 PHA02030
hypothetical protein
 302-423 8.44e-03

hypothetical protein


Pssm-ID: 222843 [Multi-domain]  Cd Length: 336  Bit Score: 39.19  E-value: 8.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84181563  302 GPDDDGQaSKRYLSEgrDLFKKLHELKAHLEKLESASTPAAVSAAAPAPSTSVPAPQQttETPKEDSRAGTPEASVTSQQ 381
Cdd:PHA02030 217 GTSDNGK-SKNFLQE--TIRKATDFPGSALHILLGGGEDLIIKPKSKAAGSNLPAVPN--VAADAGSAAAPAVPAAAAAV 291

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 84181563  382 AQSAP-VPSQP-VTSVPSQPVTSVPSQPVT-SVPSQPVtsVPSQP 423
Cdd:PHA02030 292 AQAAPsVPQVPnVAVLPDVPQVAPVAAPAApEVPAVPV--VPAAP 334
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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