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Conserved domains on  [gi|87196953|gb|ABD28936|]
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envelope glycoprotein, partial [Human endogenous retrovirus K]

Protein Classification

HERV-K_REC and HERV-K_env_2 domain-containing protein( domain architecture ID 11238902)

HERV-K_REC and HERV-K_env_2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HERV-K_env_2 pfam13804
Retro-transcribing viruses envelope glycoprotein; This family comes from human endogenous ...
 101-268 1.54e-121

Retro-transcribing viruses envelope glycoprotein; This family comes from human endogenous retrovirus K envelope glycoproteins.


:

Pssm-ID: 290518  Cd Length: 169  Bit Score: 350.97  E-value: 1.54e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87196953   101 VTWMDNPTEVYVNDSVWVPGPIDDRCPAKPEEEGMMINISIGYHYPPICLGRAPGCLMPAVQNWLVEVPIVSPISRFTYH 180
Cdd:pfam13804   2 VTWMDNPIEVYVNDSVWVPGPIDDRCPAKPEEEGMMINISIGYRYPPICLGRAPGCLMPAVQNWLVEVPTVSPISRFTYH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87196953   181 MVSGMSLRPRVNYLQDFPYQRSLKFRPKGKPCPKEIPKESKNTEVLVWEECVDNSAVILQNNEFGTIIDWAPRGQFYHNC 260
Cdd:pfam13804  82 MVSGMSLRPRVNYLQDFSYQRSLKFRPKGKPCPKEIPKESKNTEVLVWEECVANSAVILQNNEFGTIIDWAPRGQFYHNC 161


                  ....*...
gi 87196953   261 SGQTQSCP 268
Cdd:pfam13804 162 SGQTQSCP 169
HERV-K_REC pfam15695
Rec (regulator of expression encoded by corf) of HERV-K-113; REC is a family of rec proteins ...
 4-90 3.58e-56

Rec (regulator of expression encoded by corf) of HERV-K-113; REC is a family of rec proteins from the HERV-K viral polyprotein family. Rec is a functional homolog of Rev and Rex, and binds to an RNA element, the Rec-responsive element (RcRE), in the 3'LTR of HTDV/HERV-K transcripts. Thus Rec mediates nuclear export of RNA by binding to its responsive element, RcRE, present in a transcript. The human small glutamine-rich tetratricopeptide repeat-containing protein (hSGT) that controls mitotic processes and is a checkpoint protein during pro-metaphase is found to be a Rec-interacting partner.interferes with its role as a negative regulator of the androgen receptor, leading to enhanced androgen receptor activity. HERV-K(HML-2) elements benefit from this enhanced activity, as this leads to a vicious cycle that can result in increased cell proliferation, an inhibition of apoptosis, and eventually tumourigenesis.


:

Pssm-ID: 292323  Cd Length: 87  Bit Score: 180.83  E-value: 3.58e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87196953     4 NRAPLTHKMNKMVTSEEQMKLPSTKKAEPPTWAQLKKLTQLATKYLENTKVTQTPESMLLAALMIVSMVVSLPMPAGAAA 83
Cdd:pfam15695   1 NRAPLTHKMNKMVTSEEQMKLPSTKKAEPPTWAQLKKLTQLATKYLENTKVTQTPESMLLAALMIVSMVSAGPMNAGAAA 80


                  ....*..
gi 87196953    84 ANYTYWA 90
Cdd:pfam15695  81 ANIENGA 87
 
Name Accession Description Interval E-value
HERV-K_env_2 pfam13804
Retro-transcribing viruses envelope glycoprotein; This family comes from human endogenous ...
 101-268 1.54e-121

Retro-transcribing viruses envelope glycoprotein; This family comes from human endogenous retrovirus K envelope glycoproteins.


Pssm-ID: 290518  Cd Length: 169  Bit Score: 350.97  E-value: 1.54e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87196953   101 VTWMDNPTEVYVNDSVWVPGPIDDRCPAKPEEEGMMINISIGYHYPPICLGRAPGCLMPAVQNWLVEVPIVSPISRFTYH 180
Cdd:pfam13804   2 VTWMDNPIEVYVNDSVWVPGPIDDRCPAKPEEEGMMINISIGYRYPPICLGRAPGCLMPAVQNWLVEVPTVSPISRFTYH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87196953   181 MVSGMSLRPRVNYLQDFPYQRSLKFRPKGKPCPKEIPKESKNTEVLVWEECVDNSAVILQNNEFGTIIDWAPRGQFYHNC 260
Cdd:pfam13804  82 MVSGMSLRPRVNYLQDFSYQRSLKFRPKGKPCPKEIPKESKNTEVLVWEECVANSAVILQNNEFGTIIDWAPRGQFYHNC 161


                  ....*...
gi 87196953   261 SGQTQSCP 268
Cdd:pfam13804 162 SGQTQSCP 169
HERV-K_REC pfam15695
Rec (regulator of expression encoded by corf) of HERV-K-113; REC is a family of rec proteins ...
 4-90 3.58e-56

Rec (regulator of expression encoded by corf) of HERV-K-113; REC is a family of rec proteins from the HERV-K viral polyprotein family. Rec is a functional homolog of Rev and Rex, and binds to an RNA element, the Rec-responsive element (RcRE), in the 3'LTR of HTDV/HERV-K transcripts. Thus Rec mediates nuclear export of RNA by binding to its responsive element, RcRE, present in a transcript. The human small glutamine-rich tetratricopeptide repeat-containing protein (hSGT) that controls mitotic processes and is a checkpoint protein during pro-metaphase is found to be a Rec-interacting partner.interferes with its role as a negative regulator of the androgen receptor, leading to enhanced androgen receptor activity. HERV-K(HML-2) elements benefit from this enhanced activity, as this leads to a vicious cycle that can result in increased cell proliferation, an inhibition of apoptosis, and eventually tumourigenesis.


Pssm-ID: 292323  Cd Length: 87  Bit Score: 180.83  E-value: 3.58e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87196953     4 NRAPLTHKMNKMVTSEEQMKLPSTKKAEPPTWAQLKKLTQLATKYLENTKVTQTPESMLLAALMIVSMVVSLPMPAGAAA 83
Cdd:pfam15695   1 NRAPLTHKMNKMVTSEEQMKLPSTKKAEPPTWAQLKKLTQLATKYLENTKVTQTPESMLLAALMIVSMVSAGPMNAGAAA 80


                  ....*..
gi 87196953    84 ANYTYWA 90
Cdd:pfam15695  81 ANIENGA 87
 
Name Accession Description Interval E-value
HERV-K_env_2 pfam13804
Retro-transcribing viruses envelope glycoprotein; This family comes from human endogenous ...
 101-268 1.54e-121

Retro-transcribing viruses envelope glycoprotein; This family comes from human endogenous retrovirus K envelope glycoproteins.


Pssm-ID: 290518  Cd Length: 169  Bit Score: 350.97  E-value: 1.54e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87196953   101 VTWMDNPTEVYVNDSVWVPGPIDDRCPAKPEEEGMMINISIGYHYPPICLGRAPGCLMPAVQNWLVEVPIVSPISRFTYH 180
Cdd:pfam13804   2 VTWMDNPIEVYVNDSVWVPGPIDDRCPAKPEEEGMMINISIGYRYPPICLGRAPGCLMPAVQNWLVEVPTVSPISRFTYH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87196953   181 MVSGMSLRPRVNYLQDFPYQRSLKFRPKGKPCPKEIPKESKNTEVLVWEECVDNSAVILQNNEFGTIIDWAPRGQFYHNC 260
Cdd:pfam13804  82 MVSGMSLRPRVNYLQDFSYQRSLKFRPKGKPCPKEIPKESKNTEVLVWEECVANSAVILQNNEFGTIIDWAPRGQFYHNC 161


                  ....*...
gi 87196953   261 SGQTQSCP 268
Cdd:pfam13804 162 SGQTQSCP 169
HERV-K_REC pfam15695
Rec (regulator of expression encoded by corf) of HERV-K-113; REC is a family of rec proteins ...
 4-90 3.58e-56

Rec (regulator of expression encoded by corf) of HERV-K-113; REC is a family of rec proteins from the HERV-K viral polyprotein family. Rec is a functional homolog of Rev and Rex, and binds to an RNA element, the Rec-responsive element (RcRE), in the 3'LTR of HTDV/HERV-K transcripts. Thus Rec mediates nuclear export of RNA by binding to its responsive element, RcRE, present in a transcript. The human small glutamine-rich tetratricopeptide repeat-containing protein (hSGT) that controls mitotic processes and is a checkpoint protein during pro-metaphase is found to be a Rec-interacting partner.interferes with its role as a negative regulator of the androgen receptor, leading to enhanced androgen receptor activity. HERV-K(HML-2) elements benefit from this enhanced activity, as this leads to a vicious cycle that can result in increased cell proliferation, an inhibition of apoptosis, and eventually tumourigenesis.


Pssm-ID: 292323  Cd Length: 87  Bit Score: 180.83  E-value: 3.58e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87196953     4 NRAPLTHKMNKMVTSEEQMKLPSTKKAEPPTWAQLKKLTQLATKYLENTKVTQTPESMLLAALMIVSMVVSLPMPAGAAA 83
Cdd:pfam15695   1 NRAPLTHKMNKMVTSEEQMKLPSTKKAEPPTWAQLKKLTQLATKYLENTKVTQTPESMLLAALMIVSMVSAGPMNAGAAA 80


                  ....*..
gi 87196953    84 ANYTYWA 90
Cdd:pfam15695  81 ANIENGA 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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