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Conserved domains on  [gi|90739256|gb|ABD97845|]
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CG6488-like, partial [Telenomus theophilae]

Protein Classification

Dor-1 like family protein( domain architecture ID 139767)

Dor-1 like family protein similar to Schizosaccharomyces pombe exocyst complex component sec5 and conserved oligomeric Golgi complex subunit 2, as well as N-terminal region of Homo sapiens syndetin (also known as EARP/GARPII complex subunit VPS50)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG2 super family cl19297
COG (conserved oligomeric Golgi) complex component, COG2; The COG complex comprises eight ...
 1-127 6.13e-34

COG (conserved oligomeric Golgi) complex component, COG2; The COG complex comprises eight proteins COG1-8. The COG complex plays critical roles in Golgi structure and function. The proposed function of the complex is to mediate the initial physical contact between transport vesicles and their membrane targets. A comparable role in tethering vesicles has been suggested for at least six additional large multisubunit complexes, including the exocyst, a complex that mediates trafficking to the plasma membrane. COG2 structure reveals a six-helix bundle with few conserved surface features but a general resemblance to recently determined crystal structures of four different exocyst subunits. These bundles inCOG2 may act as platforms for interaction with other trafficing proteins including SNAREs (soluble N-ethylmaleimide factor attachment protein receptors) and Rabs.


The actual alignment was detected with superfamily member pfam04124:

Pssm-ID: 473160  Cd Length: 315  Bit Score: 123.69  E-value: 6.13e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90739256     1 RFLDAFTEAELRIKFLQVRDSWLQGFLNSIPKQDPNLHLTRTIELTRIHLFNIVTQYRAMFNDDEQMFLNK--DVGINES 78
Cdd:pfam04124 184 RRMPPFTENELRLKFLQARDAWLESILTALDDDNPEKYLLKTIEVCRVNLFDILTQYRAIFPEDEVVLKNAwgSWNNNGG 263

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 90739256    79 AIFYHWLEEKISQFLKTLEQDL--PGVTSIDSILGQCTYFSLSFGRVGVDF 127
Cdd:pfam04124 264 SILESWVEMKIKRFLEVLREDLyvKLGVSLSSVLGQLMYFALSFGRVGADF 314
 
Name Accession Description Interval E-value
Dor1 pfam04124
Dor1-like family; Dor1 is involved in vesicle targeting to the yeast Golgi apparatus and ...
 1-127 6.13e-34

Dor1-like family; Dor1 is involved in vesicle targeting to the yeast Golgi apparatus and complexes with a number of other trafficking proteins, which include Sec34 and Sec35.


Pssm-ID: 427729  Cd Length: 315  Bit Score: 123.69  E-value: 6.13e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90739256     1 RFLDAFTEAELRIKFLQVRDSWLQGFLNSIPKQDPNLHLTRTIELTRIHLFNIVTQYRAMFNDDEQMFLNK--DVGINES 78
Cdd:pfam04124 184 RRMPPFTENELRLKFLQARDAWLESILTALDDDNPEKYLLKTIEVCRVNLFDILTQYRAIFPEDEVVLKNAwgSWNNNGG 263

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 90739256    79 AIFYHWLEEKISQFLKTLEQDL--PGVTSIDSILGQCTYFSLSFGRVGVDF 127
Cdd:pfam04124 264 SILESWVEMKIKRFLEVLREDLyvKLGVSLSSVLGQLMYFALSFGRVGADF 314
 
Name Accession Description Interval E-value
Dor1 pfam04124
Dor1-like family; Dor1 is involved in vesicle targeting to the yeast Golgi apparatus and ...
 1-127 6.13e-34

Dor1-like family; Dor1 is involved in vesicle targeting to the yeast Golgi apparatus and complexes with a number of other trafficking proteins, which include Sec34 and Sec35.


Pssm-ID: 427729  Cd Length: 315  Bit Score: 123.69  E-value: 6.13e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90739256     1 RFLDAFTEAELRIKFLQVRDSWLQGFLNSIPKQDPNLHLTRTIELTRIHLFNIVTQYRAMFNDDEQMFLNK--DVGINES 78
Cdd:pfam04124 184 RRMPPFTENELRLKFLQARDAWLESILTALDDDNPEKYLLKTIEVCRVNLFDILTQYRAIFPEDEVVLKNAwgSWNNNGG 263

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 90739256    79 AIFYHWLEEKISQFLKTLEQDL--PGVTSIDSILGQCTYFSLSFGRVGVDF 127
Cdd:pfam04124 264 SILESWVEMKIKRFLEVLREDLyvKLGVSLSSVLGQLMYFALSFGRVGADF 314
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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