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Conserved domains on  [gi|98990077|gb|ABF60111|]
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survivin isoform 2B/3B, partial [Homo sapiens]

Protein Classification

baculoviral IAP repeat-containing protein( domain architecture ID 10460345)

baculoviral IAP repeat (BIR)-containing protein similar to human BIRC5, a multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 1-87 2.98e-22

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


:

Pssm-ID: 459891  Cd Length: 68  Bit Score: 82.71  E-value: 2.98e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 98990077     1 NWPFLEGCACTPERMAEAGFIHCPTenePDLAQCFFCFKELEGWEPDDDPIgpgtvayacntstlggrggritrEEHKKH 80
Cdd:pfam00653   7 NWPHSNKSPPTPEELAEAGFYYTGT---GDRVQCFYCGLELDGWEEGDDPW-----------------------EEHKKH 60


                  ....*..
gi 98990077    81 SSGCAFL 87
Cdd:pfam00653  61 SPDCPFL 67
 
Name Accession Description Interval E-value
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 1-87 2.98e-22

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 82.71  E-value: 2.98e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 98990077     1 NWPFLEGCACTPERMAEAGFIHCPTenePDLAQCFFCFKELEGWEPDDDPIgpgtvayacntstlggrggritrEEHKKH 80
Cdd:pfam00653   7 NWPHSNKSPPTPEELAEAGFYYTGT---GDRVQCFYCGLELDGWEEGDDPW-----------------------EEHKKH 60


                  ....*..
gi 98990077    81 SSGCAFL 87
Cdd:pfam00653  61 SPDCPFL 67
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 1-87 1.26e-18

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 73.51  E-value: 1.26e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 98990077      1 NWPFLEgcACTPERMAEAGFIHCPTenePDLAQCFFCFKELEGWEPDDDPIgpgtvayacntstlggrggritrEEHKKH 80
Cdd:smart00238  11 NWPYNS--KCTPEQLAEAGFYYTGV---GDEVKCFFCGGELDNWEPGDDPW-----------------------EEHKKW 62


                   ....*..
gi 98990077     81 SSGCAFL 87
Cdd:smart00238  63 SPNCPFV 69
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 1-87 9.18e-18

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 71.14  E-value: 9.18e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 98990077   1 NWPFleGCACTPERMAEAGFIHCpteNEPDLAQCFFCFKELEGWEPDDDPIgpgtvayacntstlggrggritrEEHKKH 80
Cdd:cd00022   9 NWPI--SLKVTPEKLAEAGFYYT---GRGDEVKCFFCGLELKNWEPGDDPW-----------------------EEHKRW 60


                ....*..
gi 98990077  81 SSGCAFL 87
Cdd:cd00022  61 SPNCPFV 67
 
Name Accession Description Interval E-value
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 1-87 2.98e-22

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 82.71  E-value: 2.98e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 98990077     1 NWPFLEGCACTPERMAEAGFIHCPTenePDLAQCFFCFKELEGWEPDDDPIgpgtvayacntstlggrggritrEEHKKH 80
Cdd:pfam00653   7 NWPHSNKSPPTPEELAEAGFYYTGT---GDRVQCFYCGLELDGWEEGDDPW-----------------------EEHKKH 60


                  ....*..
gi 98990077    81 SSGCAFL 87
Cdd:pfam00653  61 SPDCPFL 67
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 1-87 1.26e-18

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 73.51  E-value: 1.26e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 98990077      1 NWPFLEgcACTPERMAEAGFIHCPTenePDLAQCFFCFKELEGWEPDDDPIgpgtvayacntstlggrggritrEEHKKH 80
Cdd:smart00238  11 NWPYNS--KCTPEQLAEAGFYYTGV---GDEVKCFFCGGELDNWEPGDDPW-----------------------EEHKKW 62


                   ....*..
gi 98990077     81 SSGCAFL 87
Cdd:smart00238  63 SPNCPFV 69
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 1-87 9.18e-18

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 71.14  E-value: 9.18e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 98990077   1 NWPFleGCACTPERMAEAGFIHCpteNEPDLAQCFFCFKELEGWEPDDDPIgpgtvayacntstlggrggritrEEHKKH 80
Cdd:cd00022   9 NWPI--SLKVTPEKLAEAGFYYT---GRGDEVKCFFCGLELKNWEPGDDPW-----------------------EEHKRW 60


                ....*..
gi 98990077  81 SSGCAFL 87
Cdd:cd00022  61 SPNCPFV 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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