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Conserved domains on  [gi|111379239|gb|ABH09404|]
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alpha toxin, partial [Clostridium perfringens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnPC_S1P1 super family cl16915
Zinc dependent phospholipase C/S1-P1 nuclease; This model describes both the bacterial and ...
 1-97 2.86e-19

Zinc dependent phospholipase C/S1-P1 nuclease; This model describes both the bacterial and archeal zinc-dependent phospholipase C, a domain found in the alpha toxin of Clostridium perfringens, as well as S1/P1 nucleases, which predominantly act on single-stranded DNA and RNA.


The actual alignment was detected with superfamily member smart00770:

Pssm-ID: 450122  Cd Length: 241  Bit Score: 78.61  E-value: 2.86e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111379239     1 VKFETFAEERKEQYKINTAGcktnedfYADILKNkdfnawskeyargFAKTGKSIYYSHASMSHSWDDWDYAAKVTLANS 80
Cdd:smart00770 165 RKFENFVQTRKDNYSLNTEG-------EKKFLEN-------------VNKKAKKLYYSHATMSKSEKDWDYAAGEALKNA 224

                           90
                   ....*....|....*..
gi 111379239    81 QKGTAGYIYRFLHDVSE 97
Cdd:smart00770 225 QKTTAGFLYRFYNEVSN 241
 
Name Accession Description Interval E-value
Zn_dep_PLPC smart00770
Zinc dependent phospholipase C (alpha toxin); This domain conveys a zinc dependent ...
 1-97 2.86e-19

Zinc dependent phospholipase C (alpha toxin); This domain conveys a zinc dependent phospholipase C activity (EC 3.1.4.3). It is found in a monomeric phospholipase C of Bacillus cereus as well as in the alpha toxin of Clostridium perfringens and Clostridium bifermentans, which is involved in haemolysis and cell rupture. It is also found in a lecithinase of Listeria monocytogenes, which is involved in breaking the 2-membrane vacuoles that surround the bacterium. Structure information: PDB 1ca1.


Pssm-ID: 214813  Cd Length: 241  Bit Score: 78.61  E-value: 2.86e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111379239     1 VKFETFAEERKEQYKINTAGcktnedfYADILKNkdfnawskeyargFAKTGKSIYYSHASMSHSWDDWDYAAKVTLANS 80
Cdd:smart00770 165 RKFENFVQTRKDNYSLNTEG-------EKKFLEN-------------VNKKAKKLYYSHATMSKSEKDWDYAAGEALKNA 224

                           90
                   ....*....|....*..
gi 111379239    81 QKGTAGYIYRFLHDVSE 97
Cdd:smart00770 225 QKTTAGFLYRFYNEVSN 241
ZnPC_S1P1 cd10981
Zinc dependent phospholipase C/S1-P1 nuclease; This model describes both the bacterial and ...
 1-92 2.22e-15

Zinc dependent phospholipase C/S1-P1 nuclease; This model describes both the bacterial and archeal zinc-dependent phospholipase C, a domain found in the alpha toxin of Clostridium perfringens, as well as S1/P1 nucleases, which predominantly act on single-stranded DNA and RNA.


Pssm-ID: 211380  Cd Length: 238  Bit Score: 68.24  E-value: 2.22e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111379239   1 VKFETFAEERKEQYKINTAgcktneDFYADILKNKDFNAWSKEYARGFAKTGKSIYYSHASM------------SHSWDD 68
Cdd:cd10981  141 RAWETRIPELYAELYALTD------AFGDPFVGKADYIKWPKEYIWDAAKHANALYDTVLSHekelagsrkypyEGRNDV 214

                         90       100
                 ....*....|....*....|....
gi 111379239  69 WDYAAKVTLANSQKGTAGYIYRFL 92
Cdd:cd10981  215 VRKTYSEALAKAYHGLANGLVEAL 238
 
Name Accession Description Interval E-value
Zn_dep_PLPC smart00770
Zinc dependent phospholipase C (alpha toxin); This domain conveys a zinc dependent ...
 1-97 2.86e-19

Zinc dependent phospholipase C (alpha toxin); This domain conveys a zinc dependent phospholipase C activity (EC 3.1.4.3). It is found in a monomeric phospholipase C of Bacillus cereus as well as in the alpha toxin of Clostridium perfringens and Clostridium bifermentans, which is involved in haemolysis and cell rupture. It is also found in a lecithinase of Listeria monocytogenes, which is involved in breaking the 2-membrane vacuoles that surround the bacterium. Structure information: PDB 1ca1.


Pssm-ID: 214813  Cd Length: 241  Bit Score: 78.61  E-value: 2.86e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111379239     1 VKFETFAEERKEQYKINTAGcktnedfYADILKNkdfnawskeyargFAKTGKSIYYSHASMSHSWDDWDYAAKVTLANS 80
Cdd:smart00770 165 RKFENFVQTRKDNYSLNTEG-------EKKFLEN-------------VNKKAKKLYYSHATMSKSEKDWDYAAGEALKNA 224

                           90
                   ....*....|....*..
gi 111379239    81 QKGTAGYIYRFLHDVSE 97
Cdd:smart00770 225 QKTTAGFLYRFYNEVSN 241
ZnPC_S1P1 cd10981
Zinc dependent phospholipase C/S1-P1 nuclease; This model describes both the bacterial and ...
 1-92 2.22e-15

Zinc dependent phospholipase C/S1-P1 nuclease; This model describes both the bacterial and archeal zinc-dependent phospholipase C, a domain found in the alpha toxin of Clostridium perfringens, as well as S1/P1 nucleases, which predominantly act on single-stranded DNA and RNA.


Pssm-ID: 211380  Cd Length: 238  Bit Score: 68.24  E-value: 2.22e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111379239   1 VKFETFAEERKEQYKINTAgcktneDFYADILKNKDFNAWSKEYARGFAKTGKSIYYSHASM------------SHSWDD 68
Cdd:cd10981  141 RAWETRIPELYAELYALTD------AFGDPFVGKADYIKWPKEYIWDAAKHANALYDTVLSHekelagsrkypyEGRNDV 214

                         90       100
                 ....*....|....*....|....
gi 111379239  69 WDYAAKVTLANSQKGTAGYIYRFL 92
Cdd:cd10981  215 VRKTYSEALAKAYHGLANGLVEAL 238
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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