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Conserved domains on  [gi|112293733|gb|ABI14992|]
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cytochrome b, partial (mitochondrion) [Plasmodium sp. P22]

Protein Classification

cytochrome b( domain architecture ID 999997)

cytochrome b is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain; contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis

CATH:  1.20.810.10
Gene Symbol:  CYTB
Gene Ontology:  GO:0009055|GO:0046872|GO:0022904|GO:0005743|GO:0020037
PubMed:  2509716|8329437
SCOP:  4002208

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYTB super family cl33360
cytochrome b; Provisional
 1-79 4.51e-14

cytochrome b; Provisional


The actual alignment was detected with superfamily member MTH00156:

Pssm-ID: 214440 [Multi-domain]  Cd Length: 356  Bit Score: 65.19  E-value: 4.51e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293733   1 FFVLHFTFPFIALCIVFIHIFFLHLQGSTNPLGYDTAL-KIPFYPNLLSLDIKGFNNVLVLFLAQSLFGILPLSHPDNAI 79
Cdd:MTH00156 168 FFTFHFLLPFIILAMVMIHLLFLHQTGSNNPLGLNSNIdKIPFHPYFTFKDLVGFIIMLMLLILLTLINPYLLGDPENFI 247
 
Name Accession Description Interval E-value
CYTB MTH00156
cytochrome b; Provisional
 1-79 4.51e-14

cytochrome b; Provisional


Pssm-ID: 214440 [Multi-domain]  Cd Length: 356  Bit Score: 65.19  E-value: 4.51e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293733   1 FFVLHFTFPFIALCIVFIHIFFLHLQGSTNPLGYDTAL-KIPFYPNLLSLDIKGFNNVLVLFLAQSLFGILPLSHPDNAI 79
Cdd:MTH00156 168 FFTFHFLLPFIILAMVMIHLLFLHQTGSNNPLGLNSNIdKIPFHPYFTFKDLVGFIIMLMLLILLTLINPYLLGDPENFI 247
QcrB/PetB COG1290
Cytochrome b subunit of the bc complex [Energy production and conversion];
1-77 1.12e-07

Cytochrome b subunit of the bc complex [Energy production and conversion];


Pssm-ID: 440901 [Multi-domain]  Cd Length: 393  Bit Score: 47.09  E-value: 1.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293733   1 FFVLH-FTFPFIALCIVFIHIFFLHLQGSTNPLGYDTALK-----IPFYPNLLSLDIKGFNNVLVLFLAqsLFGILPLSH 74
Cdd:COG1290  189 FFALHvLLLPALLLALVVLHLWLLHRHGHNNPPGPERKKTekvdgVPFHPYYTVKDGFGFFVFLGVFAL--LAFFFPINP 266


                 ...
gi 112293733  75 PDN 77
Cdd:COG1290  267 PPN 269
Cytochrome_b_N cd00284
Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit ...
 1-29 7.57e-04

Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, cytochrome b6 is analogous to eukaryote cytochrome b, containing two chains: helices A-D are encoded by the petB gene and helices E-H are encoded by the petD gene in these organisms. Cytochrome b/b6 contains two bound hemes and two ubiquinol/ubiquinone binding sites. The C-terminal portion of cytochrome b is described in a separate CD.


Pssm-ID: 238176  Cd Length: 200  Bit Score: 36.19  E-value: 7.57e-04
                         10        20
                 ....*....|....*....|....*....
gi 112293733   1 FFVLHFTFPFIALCIVFIHIFFLHLQGST 29
Cdd:cd00284  172 FFALHFLLPFIIAVIVILHLLFLHEQGSS 200
 
Name Accession Description Interval E-value
CYTB MTH00156
cytochrome b; Provisional
 1-79 4.51e-14

cytochrome b; Provisional


Pssm-ID: 214440 [Multi-domain]  Cd Length: 356  Bit Score: 65.19  E-value: 4.51e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293733   1 FFVLHFTFPFIALCIVFIHIFFLHLQGSTNPLGYDTAL-KIPFYPNLLSLDIKGFNNVLVLFLAQSLFGILPLSHPDNAI 79
Cdd:MTH00156 168 FFTFHFLLPFIILAMVMIHLLFLHQTGSNNPLGLNSNIdKIPFHPYFTFKDLVGFIIMLMLLILLTLINPYLLGDPENFI 247
CYTB MTH00145
cytochrome b; Provisional
 1-82 7.40e-13

cytochrome b; Provisional


Pssm-ID: 177203 [Multi-domain]  Cd Length: 379  Bit Score: 61.84  E-value: 7.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293733   1 FFVLHFTFPFIALCIVFIHIFFLHLQGSTNPLGYDTAL-KIPFYPNLLSLDIKGFNNVLVLFLAQSLFGILPLSHPDNAI 79
Cdd:MTH00145 179 FFSLHFLLPFVILGLSVLHLLFLHETGSNNPLGLDSDGdKVPFHPYYTIKDLVGFVVLLFLLVFLVLFFPNLLGDPENFI 258


                 ...
gi 112293733  80 TVD 82
Cdd:MTH00145 259 PAN 261
CYTB MTH00016
cytochrome b; Validated
 1-79 7.61e-13

cytochrome b; Validated


Pssm-ID: 177102 [Multi-domain]  Cd Length: 378  Bit Score: 61.62  E-value: 7.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293733   1 FFVLHFTFPFIALCIVFIHIFFLHLQGSTNPLGYDTAL-KIPFYPNLLSLDIKGFNNVLVLFLAQSLFGILPLSHPDNAI 79
Cdd:MTH00016 179 FFALHFLLPFVIAALSMIHLLFLHQTGSNNPLGVNSNSdKVPFHPYYTSKDIVGFIVMLFLLLSVVLLWPNILGDPENFI 258
CYTB MTH00131
cytochrome b; Provisional
 1-77 3.52e-12

cytochrome b; Provisional


Pssm-ID: 177189 [Multi-domain]  Cd Length: 380  Bit Score: 60.05  E-value: 3.52e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 112293733   1 FFVLHFTFPFIALCIVFIHIFFLHLQGSTNPLGYDT-ALKIPFYPNLLSLDIKGFNNVLVLFLAQSLFGILPLSHPDN 77
Cdd:MTH00131 178 FFAFHFLFPFVIAAATILHLLFLHETGSNNPLGLNSdADKISFHPYFSYKDLLGFAILLLALTSLALFSPNLLGDPDN 255
CYTB MTH00191
cytochrome b; Provisional
 1-79 4.86e-12

cytochrome b; Provisional


Pssm-ID: 177239 [Multi-domain]  Cd Length: 365  Bit Score: 59.54  E-value: 4.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293733   1 FFVLHFTFPFIALCIVFIHIFFLHLQGSTNPLGYDT-ALKIPFYPNLLSLDIKGFNNVLVLFLAQSLFGILPLSHPDNAI 79
Cdd:MTH00191 175 FFTFHFLLPFLIAALSLIHLLFLHETGSNNPLGLNSdSDKIPFHPYFSYKDILGFFILLFLLLFLVLFSPNLLGDPENFI 254
CYTB MTH00100
cytochrome b; Provisional
 1-77 1.47e-11

cytochrome b; Provisional


Pssm-ID: 177162 [Multi-domain]  Cd Length: 379  Bit Score: 58.11  E-value: 1.47e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 112293733   1 FFVLHFTFPFIALCIVFIHIFFLHLQGSTNPLGYDT-ALKIPFYPNLLSLDIKGFNNVLVLFLAQSLFGILPLSHPDN 77
Cdd:MTH00100 178 FFAFHFILPFIITALAMVHLLFLHETGSNNPSGIPSdSDKIPFHPYYTIKDILGLLLLILTLMLLVLFSPDLLGDPDN 255
CYTB MTH00119
cytochrome b; Provisional
 1-77 8.97e-11

cytochrome b; Provisional


Pssm-ID: 214425 [Multi-domain]  Cd Length: 380  Bit Score: 56.06  E-value: 8.97e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 112293733   1 FFVLHFTFPFIALCIVFIHIFFLHLQGSTNPLGYDTAL-KIPFYPNLLSLDIKGFNNVLVLFLAQSLFGILPLSHPDN 77
Cdd:MTH00119 179 FFALHFLLPFLIAGLTLIHLLFLHETGSNNPLGLNSNTdKIPFHPYFSYKDLLGLTLMLTLLLTLALFSPNLLGDPEN 256
CYTB MTH00034
cytochrome b; Validated
 1-79 1.53e-10

cytochrome b; Validated


Pssm-ID: 177109 [Multi-domain]  Cd Length: 379  Bit Score: 55.10  E-value: 1.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293733   1 FFVLHFTFPFIALCIVFIHIFFLHLQGSTNPLGYDTAL-KIPFYPNLLSLDIKGFNNVLVLFLAQSLFGILPLSHPDNAI 79
Cdd:MTH00034 178 FFAFHFLFPFIIAALSIIHLLFLHQTGSNNPTGLNSNYdKVPFHTYFTTKDLVGFLILFAALSSLALLFPTALNDPENFI 257
CYTB MTH00074
cytochrome b; Provisional
 1-77 1.75e-10

cytochrome b; Provisional


Pssm-ID: 177145 [Multi-domain]  Cd Length: 380  Bit Score: 55.07  E-value: 1.75e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 112293733   1 FFVLHFTFPFIALCIVFIHIFFLHLQGSTNPLGYDTAL-KIPFYPNLLSLDIKGFNNVLVLFLAQSLFGILPLSHPDN 77
Cdd:MTH00074 179 FFAFHFLLPFLIAGASIIHLLFLHETGSNNPTGLNSNPdKVPFHPYFSYKDLLGFLIMLTALALLSLFSPNLLGDPDN 256
CYTB MTH00022
cytochrome b; Validated
 1-79 5.11e-08

cytochrome b; Validated


Pssm-ID: 164595 [Multi-domain]  Cd Length: 379  Bit Score: 48.16  E-value: 5.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293733   1 FFVLHFTFPFIALCIVFIHIFFLHLQGSTNPLGYDTAL-KIPFYPNLLSLDIKGFNNVLVLFLAQSLFGILPLSHPDNAI 79
Cdd:MTH00022 177 FFSLHFLFPFILAFLVIVHLIYLHVDGSNNPIGLNSSVdKVSFHVYYTSKDWYGIVVLFFLLSFIVYFAPNLLGDPENFI 256
CYTB MTH00086
cytochrome b; Provisional
 1-82 9.88e-08

cytochrome b; Provisional


Pssm-ID: 177151 [Multi-domain]  Cd Length: 355  Bit Score: 47.24  E-value: 9.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293733   1 FFVLHFTFPFIALCIVFIHIFFLHLQGSTNPLG-YDTALKIPFYPNLLSLDIKGFNNVLVLFLAqSLFGILPLSHPDNAI 79
Cdd:MTH00086 167 FFVLHFLLPWGLLVLVLFHLIFLHSTGSTSSLYcHGDYDKICFGPEYWNKDAYNIIFWLVFIIF-SLFYPFNLGDPEMFI 245


                 ...
gi 112293733  80 TVD 82
Cdd:MTH00086 246 EAD 248
QcrB/PetB COG1290
Cytochrome b subunit of the bc complex [Energy production and conversion];
1-77 1.12e-07

Cytochrome b subunit of the bc complex [Energy production and conversion];


Pssm-ID: 440901 [Multi-domain]  Cd Length: 393  Bit Score: 47.09  E-value: 1.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293733   1 FFVLH-FTFPFIALCIVFIHIFFLHLQGSTNPLGYDTALK-----IPFYPNLLSLDIKGFNNVLVLFLAqsLFGILPLSH 74
Cdd:COG1290  189 FFALHvLLLPALLLALVVLHLWLLHRHGHNNPPGPERKKTekvdgVPFHPYYTVKDGFGFFVFLGVFAL--LAFFFPINP 266


                 ...
gi 112293733  75 PDN 77
Cdd:COG1290  267 PPN 269
CYTB MTH00224
cytochrome b; Provisional
 1-79 1.81e-07

cytochrome b; Provisional


Pssm-ID: 164767 [Multi-domain]  Cd Length: 379  Bit Score: 46.45  E-value: 1.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293733   1 FFVLHFTFPFIALCIVFIHIFFLHLQGSTNPLGYDT-ALKIPFYPNLLSLDIKGFNNVLVLFLAQSLFGILPLSHPDNAI 79
Cdd:MTH00224 179 FFSFHFLLPFAIMGATILHIMFLHQTGSNNPIGINAdSARIPFHPYYSIKDALGYLIAILLLSLMVLFEPNLFTDPENFL 258
CYTB MTH00053
cytochrome b; Provisional
 1-77 7.53e-06

cytochrome b; Provisional


Pssm-ID: 164624 [Multi-domain]  Cd Length: 381  Bit Score: 42.00  E-value: 7.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293733   1 FFVLHFTFPFIALCIVFIHIFFLHLQGSTNPLGYDTAL-KIPFYPNLLSLDIKGfnNVLVLFLAQSLFGILP--LSHPDN 77
Cdd:MTH00053 179 FYSLHYLLPFILAGLALVHLIALHEDGSNNPIGVRSDIdKIPFHYYYVLKDLYG--AVILLIILSIIVFLFPysLGDAEN 256
CYTB MTH00033
cytochrome b; Provisional
 1-82 8.18e-05

cytochrome b; Provisional


Pssm-ID: 133672 [Multi-domain]  Cd Length: 383  Bit Score: 39.15  E-value: 8.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112293733   1 FFVLHFTFPFIALCIVFIHIFFLHLQGSTNPLGY-DTALKIPFYPNLLSLDIKGFnnvLVLFLAQSLFGILP-----LSH 74
Cdd:MTH00033 175 FFSLHYLLPFVLVGLVLAHLLTLHEKGSNEPLGLvGLSDRTAFHVYFTIKDILGF---LILFGVFVIIGIEPrietlLQD 251


                 ....*...
gi 112293733  75 PDNAITVD 82
Cdd:MTH00033 252 PENFIQAN 259
Cytochrome_b_N cd00284
Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit ...
 1-29 7.57e-04

Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, cytochrome b6 is analogous to eukaryote cytochrome b, containing two chains: helices A-D are encoded by the petB gene and helices E-H are encoded by the petD gene in these organisms. Cytochrome b/b6 contains two bound hemes and two ubiquinol/ubiquinone binding sites. The C-terminal portion of cytochrome b is described in a separate CD.


Pssm-ID: 238176  Cd Length: 200  Bit Score: 36.19  E-value: 7.57e-04
                         10        20
                 ....*....|....*....|....*....
gi 112293733   1 FFVLHFTFPFIALCIVFIHIFFLHLQGST 29
Cdd:cd00284  172 FFALHFLLPFIIAVIVILHLLFLHEQGSS 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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