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Conserved domains on  [gi|167887666|gb|ACA06051|]
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ras suppressor protein 1 variant 5 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-200 6.69e-37

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 133.52  E-value: 6.69e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  34 NGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 113
Cdd:COG4886  107 EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKE 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666 114 LDLTYNNLSEnsLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPkEIGELTQLKELHIQGNRLT 193
Cdd:COG4886  187 LDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLT 263


                 ....*..
gi 167887666 194 VLPPELG 200
Cdd:COG4886  264 DLPPLAN 270
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-200 6.69e-37

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 133.52  E-value: 6.69e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  34 NGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 113
Cdd:COG4886  107 EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKE 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666 114 LDLTYNNLSEnsLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPkEIGELTQLKELHIQGNRLT 193
Cdd:COG4886  187 LDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLT 263


                 ....*..
gi 167887666 194 VLPPELG 200
Cdd:COG4886  264 DLPPLAN 270
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 34-201 1.38e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 72.19  E-value: 1.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  34 NGLFTLSHITQLVLSHNKLT-MVPPNIAELKNLEVLNF-FNNQIEELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPA 110
Cdd:PLN00113 182 NSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLgYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKN 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666 111 LEVLDLTYNNLSeNSLPGNFFYLTTLRALYLSDNDF--EIlPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHI 187
Cdd:PLN00113 262 LQYLFLYQNKLS-GPIPPSIFSLQKLISLDLSDNSLsgEI-PELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQL 339

                        170
                 ....*....|....*
gi 167887666 188 QGNRLT-VLPPELGK 201
Cdd:PLN00113 340 WSNKFSgEIPKNLGK 354
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 42-193 2.07e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.56  E-value: 2.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  42 ITQLVLSHNKLTMVPpNIAELKNLEVLNFFNNQIEELPtQISSLQKLKHLNLGMNRLNTLPrGFGSLPALEVLDLTYNNL 121
Cdd:cd21340    4 ITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666 122 SENSlpgNFFYLTTLRALYLSDNDfeiLPPDiGKLTK-----------LQILSLRDNDLISLpKEIGELTQLKELHIQGN 190
Cdd:cd21340   81 SVVE---GLENLTNLEELHIENQR---LPPG-EKLTFdprslaalsnsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNN 152


                 ...
gi 167887666 191 RLT 193
Cdd:cd21340  153 QIS 155
LRR_8 pfam13855
Leucine rich repeat;
64-121 7.82e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 7.82e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666   64 NLEVLNFFNNQIEEL-PTQISSLQKLKHLNLGMNRLNTL-PRGFGSLPALEVLDLTYNNL 121
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-200 6.69e-37

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 133.52  E-value: 6.69e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  34 NGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 113
Cdd:COG4886  107 EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKE 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666 114 LDLTYNNLSEnsLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPkEIGELTQLKELHIQGNRLT 193
Cdd:COG4886  187 LDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLT 263


                 ....*..
gi 167887666 194 VLPPELG 200
Cdd:COG4886  264 DLPPLAN 270
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-202 9.50e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 103.47  E-value: 9.50e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  27 ISNMLDVNGLFTLSHITQLVLSHNKltmvppNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFG 106
Cdd:COG4886   83 SLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLG 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666 107 SLPALEVLDLTYNNLSEnslpgnffylttlralylsdndfeiLPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELH 186
Cdd:COG4886  157 NLTNLKSLDLSNNQLTD-------------------------LPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELD 211

                        170
                 ....*....|....*.
gi 167887666 187 IQGNRLTVLPPELGKM 202
Cdd:COG4886  212 LSGNQLTDLPEPLANL 227
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-204 1.19e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.70  E-value: 1.19e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  36 LFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLD 115
Cdd:COG4886  132 LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELD 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666 116 LTYNNLSenSLPGNFFYLTTLRALYLSDNDFEILP---------------------PDIGKLTKLQILSLRDNDLISLPK 174
Cdd:COG4886  212 LSGNQLT--DLPEPLANLTNLETLDLSNNQLTDLPelgnltnleeldlsnnqltdlPPLANLTNLKTLDLSNNQLTDLKL 289

                        170       180       190
                 ....*....|....*....|....*....|
gi 167887666 175 EIGELTQLKELHIQGNRLTVLPPELGKMGG 204
Cdd:COG4886  290 KELELLLGLNSLLLLLLLLNLLELLILLLL 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
57-202 2.70e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.45  E-value: 2.70e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  57 PNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRlntlprGFGSLPALEVLDLTYNNLSenSLPGNFFYLTTL 136
Cdd:COG4886   67 LLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLT--DLPEELANLTNL 138

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 167887666 137 RALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGKM 202
Cdd:COG4886  139 KELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNL 204
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
42-202 2.66e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 2.66e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  42 ITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNl 121
Cdd:COG4886   29 LLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE- 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666 122 senslpgNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGK 201
Cdd:COG4886  108 -------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGN 180


                 .
gi 167887666 202 M 202
Cdd:COG4886  181 L 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 34-201 1.38e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 72.19  E-value: 1.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  34 NGLFTLSHITQLVLSHNKLT-MVPPNIAELKNLEVLNF-FNNQIEELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPA 110
Cdd:PLN00113 182 NSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLgYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKN 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666 111 LEVLDLTYNNLSeNSLPGNFFYLTTLRALYLSDNDF--EIlPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHI 187
Cdd:PLN00113 262 LQYLFLYQNKLS-GPIPPSIFSLQKLISLDLSDNSLsgEI-PELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQL 339

                        170
                 ....*....|....*
gi 167887666 188 QGNRLT-VLPPELGK 201
Cdd:PLN00113 340 WSNKFSgEIPKNLGK 354
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
31-199 5.02e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 70.50  E-value: 5.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  31 LDVNGLFTLSH-----ITQLVLSHNKLTMVPPNIAelKNLEVLNFFNNQIEELPTQISSlqKLKHLNLGMNRLNTLPRGF 105
Cdd:PRK15370 185 LKILGLTTIPAcipeqITTLILDNNELKSLPENLQ--GNIKTLYANSNQLTSIPATLPD--TIQEMELSINRITELPERL 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666 106 GSlpALEVLDLTYNNLS--ENSLPGNFFYL-------TTLRA--------LYLSDNDFEILPPDIGklTKLQILSLRDND 168
Cdd:PRK15370 261 PS--ALQSLDLFHNKISclPENLPEELRYLsvydnsiRTLPAhlpsgithLNVQSNSLTALPETLP--PGLKTLEAGENA 336

                        170       180       190
                 ....*....|....*....|....*....|.
gi 167887666 169 LISLPKEIGelTQLKELHIQGNRLTVLPPEL 199
Cdd:PRK15370 337 LTSLPASLP--PELQVLDVSKNQITVLPETL 365
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 40-202 5.29e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.57  E-value: 5.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  40 SHITQLVLSHNKLT-MVPPNIAELKNLEVLNFFNNQIE-ELPTQISSL-QKLKHLNLGMNRLN-TLPRGFgsLPALEVLD 115
Cdd:PLN00113  69 SRVVSIDLSGKNISgKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTsSSLRYLNLSNNNFTgSIPRGS--IPNLETLD 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666 116 LTyNNLSENSLPGNFFYLTTLRALYLSDNDFE-ILPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQGNRLT 193
Cdd:PLN00113 147 LS-NNMLSGEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLS 225

                        170
                 ....*....|
gi 167887666 194 -VLPPELGKM 202
Cdd:PLN00113 226 gEIPYEIGGL 235
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
34-196 1.84e-12

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 65.95  E-value: 1.84e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  34 NGLFTL-----SHITQLVLSHNKLTMVPPNIAELKNLEV-----------------LNFFNNQIEELPTQISSLQKLKHL 91
Cdd:PRK15387 211 SGLTTLpdclpAHITTLVIPDNNLTSLPALPPELRTLEVsgnqltslpvlppglleLSIFSNPLTHLPALPSGLCKLWIF 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  92 NLGMNRLNTLPRGF----------GSLPAL--EVLDLTYNNLSENSLPGnffYLTTLRALYLSDNDFEILPPDIGKLTKL 159
Cdd:PRK15387 291 GNQLTSLPVLPPGLqelsvsdnqlASLPALpsELCKLWAYNNQLTSLPT---LPSGLQELSVSDNQLASLPTLPSELYKL 367

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 167887666 160 QILSLRDNDLISLPKEIGEL--------------TQLKELHIQGNRLTVLP 196
Cdd:PRK15387 368 WAYNNRLTSLPALPSGLKELivsgnrltslpvlpSELKELMVSGNRLTSLP 418
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
31-199 2.21e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 65.87  E-value: 2.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  31 LDVNGLFTL-----SHITQLVLSHNKLTMVPPNIAElkNLEVLNFFNNQIEELPTQISSlqKLKHLNLGMNRLNTLPRGF 105
Cdd:PRK15370 248 LSINRITELperlpSALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETL 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666 106 GslPALEVLDLTYNNLSenSLPGNFfyLTTLRALYLSDNDFEILPPDIGKltKLQILSLRDNDLISLPKEIGelTQLKEL 185
Cdd:PRK15370 324 P--PGLKTLEAGENALT--SLPASL--PPELQVLDVSKNQITVLPETLPP--TITTLDVSRNALTNLPENLP--AALQIM 393

                        170
                 ....*....|....
gi 167887666 186 HIQGNRLTVLPPEL 199
Cdd:PRK15370 394 QASRNNLVRLPESL 407
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 34-193 2.62e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.64  E-value: 2.62e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  34 NGLFTLSHITQLVLSHNKLT-MVPPNIAELKNLEVLNFFNNQIE-ELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPA 110
Cdd:PLN00113 278 PSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNN 357

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666 111 LEVLDLTYNNLSeNSLPGNFFYLTTLRALYLSDNDFE-ILPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQ 188
Cdd:PLN00113 358 LTVLDLSTNNLT-GEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDIS 436


                 ....*
gi 167887666 189 GNRLT 193
Cdd:PLN00113 437 NNNLQ 441
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 40-199 2.29e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.94  E-value: 2.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  40 SHITQLVLSHNKLT-MVPPNIAELKNLEVLNFFNNQIE-ELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPALEVLDL 116
Cdd:PLN00113 356 NNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDI 435

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666 117 TYNNLSENsLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQGNRLT-V 194
Cdd:PLN00113 436 SNNNLQGR-INSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgE 514


                 ....*
gi 167887666 195 LPPEL 199
Cdd:PLN00113 515 IPDEL 519
PLN03150 PLN03150
hypothetical protein; Provisional
 78-144 5.80e-11

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 61.37  E-value: 5.80e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 167887666  78 LPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPALEVLDLTYNNLSeNSLPGNFFYLTTLRALYLSDN 144
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFN-GSIPESLGQLTSLRILNLNGN 500
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 11-170 1.10e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.94  E-value: 1.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  11 ESREKNQPEVDMSDRGISNML-DVNGLFTLSHITQLVLSHNKLT-MVPPNIAELKNLEVLNFFNNQIE-ELPTQISSLQK 87
Cdd:PLN00113 445 NSRKWDMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKK 524

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  88 LKHLNLGMNRLN-TLPRGFGSLPALEVLDLTYNNLSeNSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRD 166
Cdd:PLN00113 525 LVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLS-GEIPKNLGNVESLVQVNISHNHLHGSLPSTGAFLAINASAVAG 603


                 ....
gi 167887666 167 NDLI 170
Cdd:PLN00113 604 NIDL 607
PLN03150 PLN03150
hypothetical protein; Provisional
 51-200 1.69e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 57.13  E-value: 1.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  51 KLTMVPP--NIAELKNLEVLNFFNNQIEELPTQISSLQKLKH-----LNLGMNRLNTLPR---------GFGSLPALEVL 114
Cdd:PLN03150 341 TIVLQPKkgTHAIINAIEVFEIITAESKTLLEEVSALQTLKSslglpLRFGWNGDPCVPQqhpwsgadcQFDSTKGKWFI 420

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666 115 D-LTYNNLS-ENSLPGNFFYLTTLRALYLSDNDFE-ILPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQGN 190
Cdd:PLN03150 421 DgLGLDNQGlRGFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGN 500

                        170
                 ....*....|.
gi 167887666 191 RLT-VLPPELG 200
Cdd:PLN03150 501 SLSgRVPAALG 511
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 42-193 2.07e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.56  E-value: 2.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  42 ITQLVLSHNKLTMVPpNIAELKNLEVLNFFNNQIEELPtQISSLQKLKHLNLGMNRLNTLPrGFGSLPALEVLDLTYNNL 121
Cdd:cd21340    4 ITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666 122 SENSlpgNFFYLTTLRALYLSDNDfeiLPPDiGKLTK-----------LQILSLRDNDLISLpKEIGELTQLKELHIQGN 190
Cdd:cd21340   81 SVVE---GLENLTNLEELHIENQR---LPPG-EKLTFdprslaalsnsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNN 152


                 ...
gi 167887666 191 RLT 193
Cdd:cd21340  153 QIS 155
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 35-174 1.10e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 1.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  35 GLFTLSHITQLVLSHNKLTMVpPNIAELKNLEVLNFFNNQIEELpTQISSLQKLKHLNLGMNRlntLPRG---------- 104
Cdd:cd21340   41 NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQR---LPPGekltfdprsl 115

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 167887666 105 FGSLPALEVLDLTYNNLSEnslPGNFFYLTTLRALYLSDN---DFEILPPDIGKLTKLQILSLRDNDLISLPK 174
Cdd:cd21340  116 AALSNSLRVLNISGNNIDS---LEPLAPLRNLEQLDASNNqisDLEELLDLLSSWPSLRELDLTGNPVCKKPK 185
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
40-193 6.50e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 46.69  E-value: 6.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  40 SHITQLVLSHNKLTMVPPNIAELKNLEVlnfFNNQIEELPTQISSLQKLKHLNlgmNRLNTLPrgfgSLPA-LEVLDLTY 118
Cdd:PRK15387 322 SELCKLWAYNNQLTSLPTLPSGLQELSV---SDNQLASLPTLPSELYKLWAYN---NRLTSLP----ALPSgLKELIVSG 391

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 167887666 119 NNLSenSLPgnfFYLTTLRALYLSDNDFEILP--PdigklTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLT 193
Cdd:PRK15387 392 NRLT--SLP---VLPSELKELMVSGNRLTSLPmlP-----SGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLS 458
LRR_8 pfam13855
Leucine rich repeat;
64-121 7.82e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 7.82e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666   64 NLEVLNFFNNQIEEL-PTQISSLQKLKHLNLGMNRLNTL-PRGFGSLPALEVLDLTYNNL 121
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
86-146 8.06e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 8.06e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 167887666   86 QKLKHLNLGMNRLNTLPRG-FGSLPALEVLDLTYNNLSENSlPGNFFYLTTLRALYLSDNDF 146
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLS-PGAFSGLPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 52-182 3.37e-05

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 44.48  E-value: 3.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666   52 LTMVPPNIAELknlevlnFFNN--QIEELPTQISSLQKLKHLNLgMN--RLNTLPRGFgSLPALEVLDL-------TYNN 120
Cdd:PLN03210  773 MTMLSPSLTRL-------FLSDipSLVELPSSIQNLHKLEHLEI-ENciNLETLPTGI-NLESLESLDLsgcsrlrTFPD 843

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 167887666  121 LSENslpgnffylttLRALYLSDNDFEILPPDIGKLTKLQILSLRD-NDLISLPKEIGELTQL 182
Cdd:PLN03210  844 ISTN-----------ISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGcNNLQRVSLNISKLKHL 895
LRR_8 pfam13855
Leucine rich repeat;
109-169 5.88e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 5.88e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 167887666  109 PALEVLDLTYNNLSENSlPGNFFYLTTLRALYLSDNDFEILPPD-IGKLTKLQILSLRDNDL 169
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLD-DGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 80-193 6.34e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 6.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  80 TQISSLQKLKHLN--LGMNRLNTLPRGFGSL-PALEVLDLTYNNLSENS---LPGNFFYLTTLRALYLSDND-----FEI 148
Cdd:cd00116  105 LRSSSLQELKLNNngLGDRGLRLLAKGLKDLpPALEKLVLGRNRLEGASceaLAKALRANRDLKELNLANNGigdagIRA 184

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 167887666 149 LPPDIGKLTKLQILSLRDNDL-----ISLPKEIGELTQLKELHIQGNRLT 193
Cdd:cd00116  185 LAEGLKANCNLEVLDLNNNGLtdegaSALAETLASLKSLEVLNLGDNNLT 234
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 40-193 4.35e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 37.33  E-value: 4.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  40 SHITQLVLSHNKLTMVP-PNIAEL----KNLEVLNFFNNQIEE-----LPTQISSLQKLKHLNLGMNRLN-----TLPRG 104
Cdd:cd00116  137 PALEKLVLGRNRLEGAScEALAKAlranRDLKELNLANNGIGDagiraLAEGLKANCNLEVLDLNNNGLTdegasALAET 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666 105 FGSLPALEVLDLTYNNLSENSL----PGNFFYLTTLRALYLSDNDfeilppdigkltklqilsLRDNDLISLPKEIGELT 180
Cdd:cd00116  217 LASLKSLEVLNLGDNNLTDAGAaalaSALLSPNISLLTLSLSCND------------------ITDDGAKDLAEVLAEKE 278

                        170
                 ....*....|...
gi 167887666 181 QLKELHIQGNRLT 193
Cdd:cd00116  279 SLLELDLRGNKFG 291
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-199 7.30e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 36.84  E-value: 7.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666  32 DVNGLFTLSHITQLVLSHNKLTMVPPnIAELKNLEVLNFFNNQIEELptqisSLQKLKHLNLGMNRLNTLPRGFGSLPAL 111
Cdd:COG4886  242 DLPELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDL-----KLKELELLLGLNSLLLLLLLLNLLELLI 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167887666 112 EVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNR 191
Cdd:COG4886  316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLT 395


                 ....*...
gi 167887666 192 LTVLPPEL 199
Cdd:COG4886  396 TTAGVLLL 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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