NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|170716582|gb|ACB31993|]
View 

solute carrier family 30 member 1, partial [Exiliboa placata]

Protein Classification

cation diffusion facilitator family transporter( domain architecture ID 1750094)

cation diffusion facilitator (CDF) family transporter facilitates the active efflux of one or more from a variety of metal cations including Zn, Cd, Ni, Co, Mn, and Cu

Gene Ontology:  GO:0008324
PubMed:  25896018|17448255
TCDB:  2.A.4

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CzcD super family cl40534
Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];
51-156 7.46e-28

Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG1230:

Pssm-ID: 440843 [Multi-domain]  Cd Length: 294  Bit Score: 105.20  E-value: 7.46e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170716582  51 YLDPALCLIMVCILLYTTYPLLKESALILLQTVPKQIDIRSLNEKLRKLEEVEAVHELHVWQLAGSRIIGTAHIKCRDPE 130
Cdd:COG1230  182 WLDPLLSLLIALLILRSAWGLLRESLRILLEGVPDGIDLEEVRAALEALPGVADVHDLHVWSLSSGENALTAHVVVDDGA 261

                         90       100
                 ....*....|....*....|....*..
gi 170716582 131 SYMKVAKDIKEIFHDE-GIHATTIQPE 156
Cdd:COG1230  262 DADAILDEIRELLAERfGIEHVTIQIE 288
 
Name Accession Description Interval E-value
CzcD COG1230
Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];
51-156 7.46e-28

Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];


Pssm-ID: 440843 [Multi-domain]  Cd Length: 294  Bit Score: 105.20  E-value: 7.46e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170716582  51 YLDPALCLIMVCILLYTTYPLLKESALILLQTVPKQIDIRSLNEKLRKLEEVEAVHELHVWQLAGSRIIGTAHIKCRDPE 130
Cdd:COG1230  182 WLDPLLSLLIALLILRSAWGLLRESLRILLEGVPDGIDLEEVRAALEALPGVADVHDLHVWSLSSGENALTAHVVVDDGA 261

                         90       100
                 ....*....|....*....|....*..
gi 170716582 131 SYMKVAKDIKEIFHDE-GIHATTIQPE 156
Cdd:COG1230  262 DADAILDEIRELLAERfGIEHVTIQIE 288
CDF TIGR01297
cation diffusion facilitator family transporter; This model describes a broadly distributed ...
 51-156 6.81e-17

cation diffusion facilitator family transporter; This model describes a broadly distributed family of transporters, a number of which have been shown to transport divalent cations of cobalt, cadmium and/or zinc. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273544 [Multi-domain]  Cd Length: 268  Bit Score: 75.72  E-value: 6.81e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170716582   51 YLDPALCLIMVCILLYTTYPLLKESALILLQTVPKQIDIRSLNEKLRKLEEVEAVHELHVWQLAGSRIIGTAHIKcRDPE 130
Cdd:TIGR01297 156 WADPIAALLISLLILYTAFRLLKESINVLLDAAPDEEDLEEIKKAILSIPGVKGVHDLHIWRIGPGKLFLDVHVV-VDPD 234

                          90       100       110
                  ....*....|....*....|....*....|..
gi 170716582  131 SYMKVAKDI-----KEIFHDE-GIHATTIQPE 156
Cdd:TIGR01297 235 LDLKQAHDIaleieREILKRHpGIEHVTIQVE 266
PRK03557 PRK03557
CDF family zinc transporter ZitB;
52-164 1.72e-10

CDF family zinc transporter ZitB;


Pssm-ID: 235130 [Multi-domain]  Cd Length: 312  Bit Score: 58.22  E-value: 1.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170716582  52 LDPALCLIMVCILLYTTYPLLKESALILLQTVPKQIDIRSLNEKL-RKLEEVEAVHELHVWQLaGSRIIGTAHIKCRDPE 130
Cdd:PRK03557 185 ADPILSILVSVLVLRSAWRLLKESVNELLEGAPVSLDIAELKRRLcREIPEVRNVHHVHVWMV-GEKPVMTLHVQVIPPH 263

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 170716582 131 SYMKVAKDIKEIFHDE-GIHATTIQPEFTIVSSGD 164
Cdd:PRK03557 264 DHDALLDRIQDYLMHHyQIEHATIQMEYQPCHGPD 298
Cation_efflux pfam01545
Cation efflux family; Members of this family are integral membrane proteins, that are found to ...
 48-80 2.51e-03

Cation efflux family; Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.


Pssm-ID: 426316 [Multi-domain]  Cd Length: 189  Bit Score: 36.87  E-value: 2.51e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 170716582   48 WVLYLDPALCLIMVCILLYTTYPLLKESALILL 80
Cdd:pfam01545 157 GGLLADPLASLLIGLLILYTALRLLKESLSILL 189
 
Name Accession Description Interval E-value
CzcD COG1230
Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];
51-156 7.46e-28

Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];


Pssm-ID: 440843 [Multi-domain]  Cd Length: 294  Bit Score: 105.20  E-value: 7.46e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170716582  51 YLDPALCLIMVCILLYTTYPLLKESALILLQTVPKQIDIRSLNEKLRKLEEVEAVHELHVWQLAGSRIIGTAHIKCRDPE 130
Cdd:COG1230  182 WLDPLLSLLIALLILRSAWGLLRESLRILLEGVPDGIDLEEVRAALEALPGVADVHDLHVWSLSSGENALTAHVVVDDGA 261

                         90       100
                 ....*....|....*....|....*..
gi 170716582 131 SYMKVAKDIKEIFHDE-GIHATTIQPE 156
Cdd:COG1230  262 DADAILDEIRELLAERfGIEHVTIQIE 288
CDF TIGR01297
cation diffusion facilitator family transporter; This model describes a broadly distributed ...
 51-156 6.81e-17

cation diffusion facilitator family transporter; This model describes a broadly distributed family of transporters, a number of which have been shown to transport divalent cations of cobalt, cadmium and/or zinc. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273544 [Multi-domain]  Cd Length: 268  Bit Score: 75.72  E-value: 6.81e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170716582   51 YLDPALCLIMVCILLYTTYPLLKESALILLQTVPKQIDIRSLNEKLRKLEEVEAVHELHVWQLAGSRIIGTAHIKcRDPE 130
Cdd:TIGR01297 156 WADPIAALLISLLILYTAFRLLKESINVLLDAAPDEEDLEEIKKAILSIPGVKGVHDLHIWRIGPGKLFLDVHVV-VDPD 234

                          90       100       110
                  ....*....|....*....|....*....|..
gi 170716582  131 SYMKVAKDI-----KEIFHDE-GIHATTIQPE 156
Cdd:TIGR01297 235 LDLKQAHDIaleieREILKRHpGIEHVTIQVE 266
PRK03557 PRK03557
CDF family zinc transporter ZitB;
52-164 1.72e-10

CDF family zinc transporter ZitB;


Pssm-ID: 235130 [Multi-domain]  Cd Length: 312  Bit Score: 58.22  E-value: 1.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170716582  52 LDPALCLIMVCILLYTTYPLLKESALILLQTVPKQIDIRSLNEKL-RKLEEVEAVHELHVWQLaGSRIIGTAHIKCRDPE 130
Cdd:PRK03557 185 ADPILSILVSVLVLRSAWRLLKESVNELLEGAPVSLDIAELKRRLcREIPEVRNVHHVHVWMV-GEKPVMTLHVQVIPPH 263

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 170716582 131 SYMKVAKDIKEIFHDE-GIHATTIQPEFTIVSSGD 164
Cdd:PRK03557 264 DHDALLDRIQDYLMHHyQIEHATIQMEYQPCHGPD 298
FieF COG0053
Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];
51-124 5.50e-06

Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];


Pssm-ID: 439823 [Multi-domain]  Cd Length: 284  Bit Score: 45.10  E-value: 5.50e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 170716582  51 YLDPALCLIMVCILLYTTYPLLKESALILLQTVPKQIDIRSLNEKLRKLEEVEAVHELHVWQlAGSRIIGTAHI 124
Cdd:COG0053  170 WLDPIAAILIGLLILKVAYKLARESLSLLMDEALDEELVERIRAIILSVPGVIGVHDLRTRK-SGPRIFVDLHI 242
Cation_efflux pfam01545
Cation efflux family; Members of this family are integral membrane proteins, that are found to ...
 48-80 2.51e-03

Cation efflux family; Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.


Pssm-ID: 426316 [Multi-domain]  Cd Length: 189  Bit Score: 36.87  E-value: 2.51e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 170716582   48 WVLYLDPALCLIMVCILLYTTYPLLKESALILL 80
Cdd:pfam01545 157 GGLLADPLASLLIGLLILYTALRLLKESLSILL 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH