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Conserved domains on  [gi|195927958|gb|ACG55638|]
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nuclear factor of activated T-cells c3 isoform ID-deltaXa [Homo sapiens]

Protein Classification

SGNH/GDSL hydrolase family protein( domain architecture ID 10285932)

SGNH/GDSL hydrolase family protein is a hydrolytic enzyme such as an esterase or lipase; may have multifunctional properties including broad substrate specificity and regiospecificity; also contains one or more N-terminal IPT/TIG domains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RHD-n super family cl08275
N-terminal sub-domain of the Rel homology domain (RHD); Proteins containing the Rel homology ...
 1-115 6.30e-83

N-terminal sub-domain of the Rel homology domain (RHD); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal sub-domain, which may be distantly related to the DNA-binding domain found in P53. The C-terminal sub-domain has an immunoglobulin-like fold and serves as a dimerization module that also binds DNA (see cd00102). The RHD is found in NF-kappa B, nuclear factor of activated T-cells (NFAT), the tonicity-responsive enhancer binding protein (TonEBP), and the arthropod proteins Dorsal and Relish (Rel).


The actual alignment was detected with superfamily member cd07881:

Pssm-ID: 447596  Cd Length: 175  Bit Score: 257.05  E-value: 6.30e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195927958   1 MFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGR 80
Cdd:cd07881   61 MFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIISNTKVLEIPLLPENNMRASIDCAGILKLRNSDIELRKGETDIGR 140

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 195927958  81 KNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQR 115
Cdd:cd07881  141 KNTRVRLVFRVHIPQPSGRVLSLQVASNPIECSQR 175
IPT_NFAT cd01178
IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a ...
 120-220 6.47e-59

IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.


:

Pssm-ID: 238583  Cd Length: 101  Bit Score: 191.93  E-value: 6.47e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195927958 120 LPHIEKYSINSCSVNGGHEMVVTGSNFLPESKIIFLEKGQDGRPQWEVEGKIIREKCQGAHIVLEVPPYHNPAVTAAVQV 199
Cdd:cd01178    1 LPEIEKKSLNSCSVNGGEELFLTGKNFLKDSKVVFQEKGQDGEAQWEAEATIDKEKSHQNHLVVEVPPYHNKHVAAPVQV 80

                         90       100
                 ....*....|....*....|.
gi 195927958 200 HFYLCNGKRKKSQSQRFTYTP 220
Cdd:cd01178   81 QFYVVNGKRKRSQPQTFTYTP 101
 
Name Accession Description Interval E-value
RHD-n_NFAT cd07881
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells ...
 1-115 6.30e-83

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes that are mainly involved in cell-cell interaction. Upon de-phosphorylation of the nuclear localization signal, NFAT enters the nucleus and acts as a transcription factor; its export from the nucleus is triggered by phosphorylation via export kinases. NFATs play important roles in mediating the immune response, and are found in T cells, B Cells, NK cells, mast cells, and monocytes. NFATs are also found in various non-hematopoietic cell types, where they play roles in development.


Pssm-ID: 143641  Cd Length: 175  Bit Score: 257.05  E-value: 6.30e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195927958   1 MFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGR 80
Cdd:cd07881   61 MFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIISNTKVLEIPLLPENNMRASIDCAGILKLRNSDIELRKGETDIGR 140

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 195927958  81 KNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQR 115
Cdd:cd07881  141 KNTRVRLVFRVHIPQPSGRVLSLQVASNPIECSQR 175
IPT_NFAT cd01178
IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a ...
 120-220 6.47e-59

IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.


Pssm-ID: 238583  Cd Length: 101  Bit Score: 191.93  E-value: 6.47e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195927958 120 LPHIEKYSINSCSVNGGHEMVVTGSNFLPESKIIFLEKGQDGRPQWEVEGKIIREKCQGAHIVLEVPPYHNPAVTAAVQV 199
Cdd:cd01178    1 LPEIEKKSLNSCSVNGGEELFLTGKNFLKDSKVVFQEKGQDGEAQWEAEATIDKEKSHQNHLVVEVPPYHNKHVAAPVQV 80

                         90       100
                 ....*....|....*....|.
gi 195927958 200 HFYLCNGKRKKSQSQRFTYTP 220
Cdd:cd01178   81 QFYVVNGKRKRSQPQTFTYTP 101
RHD_dimer pfam16179
Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural ...
 123-220 8.44e-34

Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (pfam00554) and a C-terminal dimerization domain. This is the dimerization domain.


Pssm-ID: 465045  Cd Length: 102  Bit Score: 124.21  E-value: 8.44e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195927958  123 IEKYSINSCSVNGGHEMVVTGSNFLPE-SKIIFLEKGqDGRPQWEVEGKIIREKC-QGAHIVLEVPPYHNPAVTAAVQVH 200
Cdd:pfam16179   2 ICRLSLCSGSVTGGEEIILLCEKVLKDdIKVRFYEED-DGQEVWEAEGDFSKTDVhRQVAIVFKTPPYRDPDITEPVTVN 80

                          90       100
                  ....*....|....*....|.
gi 195927958  201 FYLCNGKRKK-SQSQRFTYTP 220
Cdd:pfam16179  81 IQLRRPSDKAtSEPQPFTYLP 101
RHD_DNA_bind pfam00554
Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are ...
 2-113 9.80e-17

Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam16179) that functions as a dimerization domain.


Pssm-ID: 425749  Cd Length: 169  Bit Score: 78.12  E-value: 9.80e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195927958    2 FIGTADDRYlRPHAfyqvHRITGKTvatasqeiiiASTKVLEIPLLPENnMSASIDCAGILKLRNSDIELRKGE---TDI 78
Cdd:pfam00554  55 SLVTKDEPH-RPHP----HSLVGKD----------CKDGVCEVELGPED-MVASFQNLGIQCVKKKDVEEALKErieLNI 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 195927958   79 GRKN--------------TRVRLVFRVHIP--QPSGKVLSLQIASIPVECS 113
Cdd:pfam00554 119 DPFNvgfealrqikdmdlNVVRLCFQAFLPdtRGNFTTPLPPVVSNPIYDK 169
IPT smart00429
ig-like, plexins, transcription factors;
120-219 3.91e-13

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 65.13  E-value: 3.91e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195927958   120 LPHIEKYSINSCSVNGGHEMVVTGSNFLPESKIIFLEKGqdgrpqWEVEGKIIREKcqGAHIVLEVPPYHNPAVTAAVQv 199
Cdd:smart00429   1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGV------GEAPCTFSPSS--STAIVCKTPPYHNIPGSVPVR- 71

                           90       100
                   ....*....|....*....|
gi 195927958   200 HFYLCNGKRkKSQSQRFTYT 219
Cdd:smart00429  72 TVGLRNGGV-PSSPQPFTYV 90
 
Name Accession Description Interval E-value
RHD-n_NFAT cd07881
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells ...
 1-115 6.30e-83

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes that are mainly involved in cell-cell interaction. Upon de-phosphorylation of the nuclear localization signal, NFAT enters the nucleus and acts as a transcription factor; its export from the nucleus is triggered by phosphorylation via export kinases. NFATs play important roles in mediating the immune response, and are found in T cells, B Cells, NK cells, mast cells, and monocytes. NFATs are also found in various non-hematopoietic cell types, where they play roles in development.


Pssm-ID: 143641  Cd Length: 175  Bit Score: 257.05  E-value: 6.30e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195927958   1 MFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGR 80
Cdd:cd07881   61 MFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIISNTKVLEIPLLPENNMRASIDCAGILKLRNSDIELRKGETDIGR 140

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 195927958  81 KNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQR 115
Cdd:cd07881  141 KNTRVRLVFRVHIPQPSGRVLSLQVASNPIECSQR 175
IPT_NFAT cd01178
IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a ...
 120-220 6.47e-59

IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.


Pssm-ID: 238583  Cd Length: 101  Bit Score: 191.93  E-value: 6.47e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195927958 120 LPHIEKYSINSCSVNGGHEMVVTGSNFLPESKIIFLEKGQDGRPQWEVEGKIIREKCQGAHIVLEVPPYHNPAVTAAVQV 199
Cdd:cd01178    1 LPEIEKKSLNSCSVNGGEELFLTGKNFLKDSKVVFQEKGQDGEAQWEAEATIDKEKSHQNHLVVEVPPYHNKHVAAPVQV 80

                         90       100
                 ....*....|....*....|.
gi 195927958 200 HFYLCNGKRKKSQSQRFTYTP 220
Cdd:cd01178   81 QFYVVNGKRKRSQPQTFTYTP 101
RHD-n_NFAT_like cd07927
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells ...
 1-114 2.60e-44

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins and similar proteins; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes that are mainly involved in cell-cell interaction. Upon de-phosphorylation of the nuclear localization signal, NFAT enters the nucleus and acts as a transcription factor; its export from the nucleus is triggered by phosphorylation via export kinases. NFATs play important roles in mediating the immune response, and are found in T cells, B Cells, NK cells, mast cells, and monocytes. NFATs are also found in various non-hematopoietic cell types, where they play roles in development. This group also contains the N-terminal RHD sub-domain of the non-calcium regulated tonicity-responsive enhancer binding protein (TonEBP), also called NFAT5. Mammalian TonEBP regulates the expression of genes in response to tonicity. It plays a pivotal role in urinary concentrating mechanisms in kidney medulla, by triggering the accumulation of osmolytes that enable renal medullary cells to tolerate high levels of urea and salt.


Pssm-ID: 143648  Cd Length: 161  Bit Score: 155.12  E-value: 2.60e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195927958   1 MFIGTADDRyLRPHAFYQVHRITGKTvATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGR 80
Cdd:cd07927   50 VFIGTASGR-LKPHAFYQVHRITGKT-TTPCKEKIIGNTKVLEIPLEPKNNMTATIDCAGILKLRNADIELRKGETDIKK 127

                         90       100       110
                 ....*....|....*....|....*....|....
gi 195927958  81 KNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQ 114
Cdd:cd07927  128 KNTRARLVFRVHIPEKDGRIVSLQTASNPIECSQ 161
IPT_TF cd00602
IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated ...
 121-220 7.32e-37

IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated Tcells (NFAT), and recombination signal J-kappa binding protein (RBP-Jkappa). The IPT domains in these proteins are involved in DNA binding. Most NF-kappaB/Rel proteins form homo- and heterodimers, while NFAT proteins are largely monomeric (with TonEBP being an exception). While the majority of sequence-specific DNA binding elements are found in the N-terminal domain, several are found in the IPT domain in loops adjacent to, and including, the linker region.


Pssm-ID: 238336  Cd Length: 101  Bit Score: 132.41  E-value: 7.32e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195927958 121 PHIEKYSINSCSVNGGHEMVVTGSNFL-PESKIIFLEKGQdGRPQWEVEGKIIREKCQGAHIVLEVPPYHNPAVTAAVQV 199
Cdd:cd00602    1 LPICRVSSLSGSVNGGDEVFLLCDKVNkPDIKVWFGEKGP-GETVWEAEAMFRQEDVRQVAIVFKTPPYHNKWITRPVQV 79

                         90       100
                 ....*....|....*....|..
gi 195927958 200 HFYLCNG-KRKKSQSQRFTYTP 220
Cdd:cd00602   80 PIQLVRPdDRKRSEPLTFTYTP 101
RHD-n_TonEBP cd07882
N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding ...
 1-114 6.30e-36

N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the tonicity-responsive enhancer binding protein (TonEBP), also called NFAT5. Mammalian TonEBP regulates the expression of genes in response to tonicity. It plays a pivotal role in urinary concentrating mechanisms in kidney medulla, by triggering the accumulation of osmolytes that enable renal medullary cells to tolerate high levels of urea and salt.


Pssm-ID: 143642  Cd Length: 161  Bit Score: 132.25  E-value: 6.30e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195927958   1 MFIGTADDRyLRPHAFYQVHRITGKTvATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGR 80
Cdd:cd07882   50 VFVGTDSGR-VKPHGFYQACKVTGRN-TTPCEEVDVEGTTVIEVPLDPTNNMTISVDCVGILKLRNADVEARIGIARSKK 127

                         90       100       110
                 ....*....|....*....|....*....|....
gi 195927958  81 KNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQ 114
Cdd:cd07882  128 KSTRVRLVFRVIIPRKDGSTLTLQTVSNPILCTQ 161
RHD_dimer pfam16179
Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural ...
 123-220 8.44e-34

Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (pfam00554) and a C-terminal dimerization domain. This is the dimerization domain.


Pssm-ID: 465045  Cd Length: 102  Bit Score: 124.21  E-value: 8.44e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195927958  123 IEKYSINSCSVNGGHEMVVTGSNFLPE-SKIIFLEKGqDGRPQWEVEGKIIREKC-QGAHIVLEVPPYHNPAVTAAVQVH 200
Cdd:pfam16179   2 ICRLSLCSGSVTGGEEIILLCEKVLKDdIKVRFYEED-DGQEVWEAEGDFSKTDVhRQVAIVFKTPPYRDPDITEPVTVN 80

                          90       100
                  ....*....|....*....|.
gi 195927958  201 FYLCNGKRKK-SQSQRFTYTP 220
Cdd:pfam16179  81 IQLRRPSDKAtSEPQPFTYLP 101
RHD-n cd07827
N-terminal sub-domain of the Rel homology domain (RHD); Proteins containing the Rel homology ...
 2-114 2.64e-19

N-terminal sub-domain of the Rel homology domain (RHD); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal sub-domain, which may be distantly related to the DNA-binding domain found in P53. The C-terminal sub-domain has an immunoglobulin-like fold and serves as a dimerization module that also binds DNA (see cd00102). The RHD is found in NF-kappa B, nuclear factor of activated T-cells (NFAT), the tonicity-responsive enhancer binding protein (TonEBP), and the arthropod proteins Dorsal and Relish (Rel).


Pssm-ID: 143640  Cd Length: 174  Bit Score: 85.50  E-value: 2.64e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195927958   2 FIGTADDRYlRPHAfYQVHRITGktvatasqeiiiASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETD---- 77
Cdd:cd07827   57 SLVTKDDPP-KPHP-HQLVGKTD------------CRDGVCEVRLGPKNNMTASFNNLGIQCVRKKDVEEALGQRIqlgi 122

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 195927958  78 -------------IGRKNTRVRLVFRVHIPQPSGK--VLSLQIASIPVECSQ 114
Cdd:cd07827  123 dpfmvhkgpegnaSDIDLNRVRLCFQAFIEDSDGGftLPLPPVLSNPIYDKK 174
RHD_DNA_bind pfam00554
Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are ...
 2-113 9.80e-17

Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam16179) that functions as a dimerization domain.


Pssm-ID: 425749  Cd Length: 169  Bit Score: 78.12  E-value: 9.80e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195927958    2 FIGTADDRYlRPHAfyqvHRITGKTvatasqeiiiASTKVLEIPLLPENnMSASIDCAGILKLRNSDIELRKGE---TDI 78
Cdd:pfam00554  55 SLVTKDEPH-RPHP----HSLVGKD----------CKDGVCEVELGPED-MVASFQNLGIQCVKKKDVEEALKErieLNI 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 195927958   79 GRKN--------------TRVRLVFRVHIP--QPSGKVLSLQIASIPVECS 113
Cdd:pfam00554 119 DPFNvgfealrqikdmdlNVVRLCFQAFLPdtRGNFTTPLPPVVSNPIYDK 169
IPT smart00429
ig-like, plexins, transcription factors;
120-219 3.91e-13

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 65.13  E-value: 3.91e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195927958   120 LPHIEKYSINSCSVNGGHEMVVTGSNFLPESKIIFLEKGqdgrpqWEVEGKIIREKcqGAHIVLEVPPYHNPAVTAAVQv 199
Cdd:smart00429   1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGV------GEAPCTFSPSS--STAIVCKTPPYHNIPGSVPVR- 71

                           90       100
                   ....*....|....*....|
gi 195927958   200 HFYLCNGKRkKSQSQRFTYT 219
Cdd:smart00429  72 TVGLRNGGV-PSSPQPFTYV 90
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 121-220 6.68e-09

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 53.23  E-value: 6.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195927958 121 PHIEKYSINSCSVNGGHEMVVTGSNFLPES--KIIFLekgqdgrpqweVEGKIIREKCQGAHIVLEVPPYHNPavtAAVQ 198
Cdd:cd00102    1 PVITSISPSSGPVSGGTEVTITGSNFGSGSnlRVTFG-----------GGVPCSVLSVSSTAIVCTTPPYANP---GPGP 66

                         90       100
                 ....*....|....*....|...
gi 195927958 199 VHFYLCN-GKRKKSQSQRFTYTP 220
Cdd:cd00102   67 VEVTVDRgNGGITSSPLTFTYVP 89
IPT_NFkappaB cd01177
IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is ...
 129-220 4.17e-03

IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to certain chemicals. NFkappaB blocking cell apoptosis in several cell types, gives it an important role in cell proliferation and differentiation.


Pssm-ID: 238582  Cd Length: 102  Bit Score: 36.91  E-value: 4.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195927958 129 NSCSVNGGHEMvvtgsNFLPES------KIIFLEKgQDGRPQWEVEGKIIREKCQGAH-IVLEVPPYHNPAVTAAVQVHF 201
Cdd:cd01177    9 TSGSVKGGDEV-----YLLCDKvqkediQVRFFEE-DEEETVWEAFGDFSQTDVHRQYaIVFRTPPYHDPDITEPVKVKI 82

                         90       100
                 ....*....|....*....|...
gi 195927958 202 YLcngKRK----KSQSQRFTYTP 220
Cdd:cd01177   83 QL---KRPsdgeRSESVPFTYVP 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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