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Conserved domains on  [gi|387537433|gb|ACN43205|]
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DNA gyrase subunit A, partial [Bacillus subtilis]

Protein Classification

DNA gyrase subunit A family protein( domain architecture ID 1000081)

DNA gyrase subunit A (GyrA) forms a 2:2 heterotetrameric complex with GyrB to form gyrase, a type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state; may be partial

CATH:  1.10.268.10|3.90.199.10
PubMed:  11395412|9519293|17397985

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05560 super family cl35335
DNA gyrase subunit A; Validated
 1-430 0e+00

DNA gyrase subunit A; Validated


The actual alignment was detected with superfamily member PRK05560:

Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 924.05  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDT 80
Cdd:PRK05560  60 YKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKET 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  81 IDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIQELMEVIPGPDFPTAGQ 160
Cdd:PRK05560 140 VDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACLALIDNPDITIEELMEIIPGPDFPTGGI 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 161 ILGRSGIRKAYESGRGSITIRAKAEIEQTSsGKERIIVTELPYQVNKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRI 240
Cdd:PRK05560 220 ILGRSGIREAYRTGRGSIVMRAKAEIEEIK-GREAIIVTEIPYQVNKARLIEKIAELVKEKKIEGISDLRDESDRDGMRI 298

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 241 VIEIRRDANGNVILNNLYKQTALQTSFGINLLALVDGQPKVLNLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGL 320
Cdd:PRK05560 299 VIELKRDAVPEVVLNNLYKHTQLQTSFGINMLALVDGQPKLLNLKEILEAFLEHRKEVITRRTRFELRKAEERAHILEGL 378

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 321 RVALDHLDAVISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKLIGELKDILANEYK 400
Cdd:PRK05560 379 LIALDNIDEVIALIRASPTPAEAKEGLMERFGLSEIQAQAILDMRLQRLTGLERDKIEDEYKELLALIADLKDILASPER 458

                        410       420       430
                 ....*....|....*....|....*....|
gi 387537433 401 VLEIIREELTEIKERFNDERRTEIVTSGLE 430
Cdd:PRK05560 459 LLEIIKEELLEIKEKFGDPRRTEIIEGEGD 488
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 1-430 0e+00

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 924.05  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDT 80
Cdd:PRK05560  60 YKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKET 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  81 IDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIQELMEVIPGPDFPTAGQ 160
Cdd:PRK05560 140 VDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACLALIDNPDITIEELMEIIPGPDFPTGGI 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 161 ILGRSGIRKAYESGRGSITIRAKAEIEQTSsGKERIIVTELPYQVNKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRI 240
Cdd:PRK05560 220 ILGRSGIREAYRTGRGSIVMRAKAEIEEIK-GREAIIVTEIPYQVNKARLIEKIAELVKEKKIEGISDLRDESDRDGMRI 298

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 241 VIEIRRDANGNVILNNLYKQTALQTSFGINLLALVDGQPKVLNLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGL 320
Cdd:PRK05560 299 VIELKRDAVPEVVLNNLYKHTQLQTSFGINMLALVDGQPKLLNLKEILEAFLEHRKEVITRRTRFELRKAEERAHILEGL 378

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 321 RVALDHLDAVISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKLIGELKDILANEYK 400
Cdd:PRK05560 379 LIALDNIDEVIALIRASPTPAEAKEGLMERFGLSEIQAQAILDMRLQRLTGLERDKIEDEYKELLALIADLKDILASPER 458

                        410       420       430
                 ....*....|....*....|....*....|
gi 387537433 401 VLEIIREELTEIKERFNDERRTEIVTSGLE 430
Cdd:PRK05560 459 LLEIIKEELLEIKEKFGDPRRTEIIEGEGD 488
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-430 0e+00

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 894.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDT 80
Cdd:COG0188   65 YKKSARVVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARLAKIAEELLADIDKDT 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  81 IDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIQELMEVIPGPDFPTAGQ 160
Cdd:COG0188  145 VDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACIALIDNPDATIEELMEYIPGPDFPTGGI 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 161 ILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRI 240
Cdd:COG0188  225 IVGREGIREAYETGRGSIRVRAKAEIEELKRGREQIVVTEIPYQVNKARLIEKIAELVKEKKIEGISDVRDESDRDGMRI 304

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 241 VIEIRRDANGNVILNNLYKQTALQTSFGINLLALVDGQPKVLNLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGL 320
Cdd:COG0188  305 VIELKRDANPEVVLNQLYKHTQLQTSFGINMLALVDGRPRVLNLKEILEAFLDHRREVVTRRTQFELRKAEERAHILEGL 384

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 321 RVALDHLDAVISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKLIGELKDILANEYK 400
Cdd:COG0188  385 LIALDNIDEVIAIIRASKDPDEAKEALMERFGLSEIQAEAILDMRLRRLTGLEREKIEDEYAELLKEIAELEDILASEER 464

                        410       420       430
                 ....*....|....*....|....*....|
gi 387537433 401 VLEIIREELTEIKERFNDERRTEIVTSGLE 430
Cdd:COG0188  465 LLKIIKEELLEIKKKYGDERRTEIEEAEGE 494
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 1-431 0e+00

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 808.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433    1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDT 80
Cdd:TIGR01063  56 YKKSARIVGDVMGKYHPHGDSAIYDTLVRMAQDFSLRYPLVDGQGNFGSIDGDPPAAMRYTEARLTKIAEELLRDIDKET 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   81 IDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIQELMEVIPGPDFPTAGQ 160
Cdd:TIGR01063 136 VDFVPNYDGSEQEPTVLPSRFPNLLVNGSSGIAVGMATNIPPHNLGEIIDALLAYIDNPDISIQELLEVIKGPDFPTGGI 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  161 ILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRI 240
Cdd:TIGR01063 216 ILGRSGIRSAYETGRGSIVIRARAEIEEDSKGREAIIVTEIPYQVNKARLIEKIAELVREKKIEGISDIRDESDREGIRI 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  241 VIEIRRDANGNVILNNLYKQTALQTSFGINLLALVDGQPKVLNLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGL 320
Cdd:TIGR01063 296 VIELKRDAVAEVVLNNLYKQTQLQVSFGINMLALVKGLPKVLNLKELLEAFVEHRKDVITRRTIFELRKAEERAHILEGL 375

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  321 RVALDHLDAVISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKLIGELKDILANEYK 400
Cdd:TIGR01063 376 LIALDNIDEVIALIRASQNTEEAKTRLVERFSLSEIQAQAILDMRLQRLTGLEREKLQEEYKELLELIADLEDILASEER 455

                         410       420       430
                  ....*....|....*....|....*....|.
gi 387537433  401 VLEIIREELTEIKERFNDERRTEIVTSGLET 431
Cdd:TIGR01063 456 VLEIIREELEEIKEQFGDPRRTEIVYDESED 486
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 1-412 0e+00

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 648.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDT 80
Cdd:cd00187   34 EKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNFGSRDGDDAAAMRYTETRLSPIARLLLPDIDDPT 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  81 IDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIQELMEVIPGPDFPTAGQ 160
Cdd:cd00187  114 VDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLREVIDALRALIDNPEASIDELMEIIKGPDFPTGGI 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 161 ILGRSGIRKAYESGRGSITIRAKAEIEqTSSGKERIIVTELPYQVNKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRI 240
Cdd:cd00187  194 IEGRAGIREAYETGRGRYIIRGKYEIE-DDEGRNTIEITELPYQVNKAKLKEKIAELVKDKKIEGISDVRDESDREGIRF 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 241 VIEIRRDANGNVILNNLYKQTALQTSFGINLLALV-DGQPKVLNLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEG 319
Cdd:cd00187  273 VIELKRGAMAEVVLNGLYKVTKLQTTFGINMVAFDpNGRPKKLNLKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEG 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 320 LRVALDHLDAVISLIRNSqtaEIARTGLIEQF---SLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKLIGELKDILA 396
Cdd:cd00187  353 LLKAILNIDEVINLIRSS---DEAKKALIEELeklGFSEIQADAILDMRLRRLTKLEREKLLKELKELEAEIEDLEKILA 429

                        410
                 ....*....|....*.
gi 387537433 397 NEYKVLEIIREELTEI 412
Cdd:cd00187  430 SEERPKDLWKEELDEF 445
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
1-409 0e+00

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 585.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433    1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV-DGDSAAAMRYTEARMSKISMEILRDITKD 79
Cdd:pfam00521  31 YKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGSRiDGDKDAAMRYTETRLSKIARELFPDIDDD 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   80 TIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIqeLMEVIPGPDFPTAG 159
Cdd:pfam00521 111 TVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREIIDALIALLDGPEATL--LMKYIMGPDFPTGG 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  160 QILGRSGIRKAYESGRGSITIRAKAEIEQtssgKERIIVTELPYQVNKAKLIEKIADLVRDKKIEGITDLRDESDRtGMR 239
Cdd:pfam00521 189 GIIGKGGIKEAYKTGRGKITVRAKVEIED----RKTIVITELPYGVWTSDLIEKIEELVKNGKIKGISDIRDESDR-GVR 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  240 IVIEIRRDANGNVILNNLYKQTALQTSFGINLLALVDGQPKVLNLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEG 319
Cdd:pfam00521 264 IVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDGGPKYLGLKEILKEFLDHRLEVYERRKEYLLEKLEERLHILEG 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  320 LRVALDHLDAVISLIRNSQTAEIARTGLIEQfsLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKLIGELKDILANEY 399
Cdd:pfam00521 344 LLIALNNIDFVIEIIRGSIDRKKAKKNLIEE--LSEIQADYLLDMRLRRLTKEEVDKLLEEIDELEKEIAELEKLLASEK 421

                         410
                  ....*....|
gi 387537433  400 KVLEIIREEL 409
Cdd:pfam00521 422 KLNDLWIEEL 431
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 1-398 0e+00

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 564.88  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433     1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV-DGDSAAAMRYTEARMSKISMEILRDITKD 79
Cdd:smart00434  53 KVKSARGVGDVMGKYHPHGDSSLYDTIVRMAQDFSNNYPLLDGQGNFGSRlDGDDAAAMRYTETRLSPLARLLLPDIDKD 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433    80 TIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIQELMEVIPGPDFPTAG 159
Cdd:smart00434 133 TVDFVPNYDGQEIEPTVLPPIIPNLLVNGSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASIDELMMIPWGPDFPTGG 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   160 QILGRSgirkayesgrgSITIRAKAEIEqtssGKERIIVTELPYQVNKAKLIEKIADLVRDKKIEGITDLRDES-DRTGM 238
Cdd:smart00434 213 EIVGPG-----------KYVVRGKIEIE----DDNTIVITELPYQVNTADLIEKIAELVKDKKIEGIIDVRDEShDRTGV 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   239 RIVIEIRRDANGNVILNNLYKQTALQTSFGINLLALVD-GQPKVLNLKQCLEHYLDHQKVVIRRRTAYELRKAE-ARAHI 316
Cdd:smart00434 278 RIVIELKRGAMAEVVLNGLYKLTKLQTTFSINMLALFDnGRPKKYNLKEILKEFLDHRLEVYTRRKEYLLGKLEaERLHI 357

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   317 LEGLRVALDHLDAVISLIRNSQ-TAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKLIGELKDIL 395
Cdd:smart00434 358 LEGLFIALSIIDEIIVLIRSSKdLAKEAKEKLMERFELSEIQADAILDMRLRRLTKLEVEKLEKELKELEKEIEDLEKIL 437


                   ...
gi 387537433   396 ANE 398
Cdd:smart00434 438 ASE 440
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 1-430 0e+00

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 924.05  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDT 80
Cdd:PRK05560  60 YKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKET 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  81 IDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIQELMEVIPGPDFPTAGQ 160
Cdd:PRK05560 140 VDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACLALIDNPDITIEELMEIIPGPDFPTGGI 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 161 ILGRSGIRKAYESGRGSITIRAKAEIEQTSsGKERIIVTELPYQVNKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRI 240
Cdd:PRK05560 220 ILGRSGIREAYRTGRGSIVMRAKAEIEEIK-GREAIIVTEIPYQVNKARLIEKIAELVKEKKIEGISDLRDESDRDGMRI 298

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 241 VIEIRRDANGNVILNNLYKQTALQTSFGINLLALVDGQPKVLNLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGL 320
Cdd:PRK05560 299 VIELKRDAVPEVVLNNLYKHTQLQTSFGINMLALVDGQPKLLNLKEILEAFLEHRKEVITRRTRFELRKAEERAHILEGL 378

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 321 RVALDHLDAVISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKLIGELKDILANEYK 400
Cdd:PRK05560 379 LIALDNIDEVIALIRASPTPAEAKEGLMERFGLSEIQAQAILDMRLQRLTGLERDKIEDEYKELLALIADLKDILASPER 458

                        410       420       430
                 ....*....|....*....|....*....|
gi 387537433 401 VLEIIREELTEIKERFNDERRTEIVTSGLE 430
Cdd:PRK05560 459 LLEIIKEELLEIKEKFGDPRRTEIIEGEGD 488
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-430 0e+00

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 894.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDT 80
Cdd:COG0188   65 YKKSARVVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARLAKIAEELLADIDKDT 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  81 IDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIQELMEVIPGPDFPTAGQ 160
Cdd:COG0188  145 VDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACIALIDNPDATIEELMEYIPGPDFPTGGI 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 161 ILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRI 240
Cdd:COG0188  225 IVGREGIREAYETGRGSIRVRAKAEIEELKRGREQIVVTEIPYQVNKARLIEKIAELVKEKKIEGISDVRDESDRDGMRI 304

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 241 VIEIRRDANGNVILNNLYKQTALQTSFGINLLALVDGQPKVLNLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGL 320
Cdd:COG0188  305 VIELKRDANPEVVLNQLYKHTQLQTSFGINMLALVDGRPRVLNLKEILEAFLDHRREVVTRRTQFELRKAEERAHILEGL 384

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 321 RVALDHLDAVISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKLIGELKDILANEYK 400
Cdd:COG0188  385 LIALDNIDEVIAIIRASKDPDEAKEALMERFGLSEIQAEAILDMRLRRLTGLEREKIEDEYAELLKEIAELEDILASEER 464

                        410       420       430
                 ....*....|....*....|....*....|
gi 387537433 401 VLEIIREELTEIKERFNDERRTEIVTSGLE 430
Cdd:COG0188  465 LLKIIKEELLEIKKKYGDERRTEIEEAEGE 494
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 1-431 0e+00

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 808.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433    1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDT 80
Cdd:TIGR01063  56 YKKSARIVGDVMGKYHPHGDSAIYDTLVRMAQDFSLRYPLVDGQGNFGSIDGDPPAAMRYTEARLTKIAEELLRDIDKET 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   81 IDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIQELMEVIPGPDFPTAGQ 160
Cdd:TIGR01063 136 VDFVPNYDGSEQEPTVLPSRFPNLLVNGSSGIAVGMATNIPPHNLGEIIDALLAYIDNPDISIQELLEVIKGPDFPTGGI 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  161 ILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRI 240
Cdd:TIGR01063 216 ILGRSGIRSAYETGRGSIVIRARAEIEEDSKGREAIIVTEIPYQVNKARLIEKIAELVREKKIEGISDIRDESDREGIRI 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  241 VIEIRRDANGNVILNNLYKQTALQTSFGINLLALVDGQPKVLNLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGL 320
Cdd:TIGR01063 296 VIELKRDAVAEVVLNNLYKQTQLQVSFGINMLALVKGLPKVLNLKELLEAFVEHRKDVITRRTIFELRKAEERAHILEGL 375

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  321 RVALDHLDAVISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKLIGELKDILANEYK 400
Cdd:TIGR01063 376 LIALDNIDEVIALIRASQNTEEAKTRLVERFSLSEIQAQAILDMRLQRLTGLEREKLQEEYKELLELIADLEDILASEER 455

                         410       420       430
                  ....*....|....*....|....*....|.
gi 387537433  401 VLEIIREELTEIKERFNDERRTEIVTSGLET 431
Cdd:TIGR01063 456 VLEIIREELEEIKEQFGDPRRTEIVYDESED 486
PRK05561 PRK05561
DNA topoisomerase 4 subunit A;
1-425 0e+00

DNA topoisomerase 4 subunit A;


Pssm-ID: 235503 [Multi-domain]  Cd Length: 742  Bit Score: 685.30  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDT 80
Cdd:PRK05561  65 FKKSARVVGDVLGKYHPHGDSSIYDAMVRMAQDFSYRYPLVDGQGNFGSIDGDPAAAMRYTEARLSPIAELLLEEIDEGT 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  81 IDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIQELMEVIPGPDFPTAGQ 160
Cdd:PRK05561 145 VDFVPNFDGTLKEPTVLPARFPNLLLNGATGIAVGMATDIPPHNLREVIDAAIHLIDNPDATLEELMEFVPGPDFPTGGE 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 161 IL-GRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEKIADLVRDKKIEGITDLRDESDRTG-M 238
Cdd:PRK05561 225 IItGRDGIRKAYETGRGSIRVRARWEIEDLAGGRWQIVITELPYQVSKAKLIEQIAELMNAKKLPGIADVRDESDRENpV 304

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 239 RIVIEIR-RDANGNVILNNLYKQTALQTSFGINLLAL-VDGQPKVLNLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHI 316
Cdd:PRK05561 305 RIVIEPKsNRVDPEALMNHLFATTDLESSYRVNMNAIgLDGRPRVKGLKEILSEWLDHRREVVTRRSQFRLDKVEKRLHI 384

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 317 LEGLRVALDHLDAVISLIRNSqtaEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKLIGELKDILA 396
Cdd:PRK05561 385 LEGLLIAFLNIDEVIRIIRES---DEPKANLMARFDLSEIQAEAILELRLRRLAKLEEIEIRKEQDELRKEIAELEAILA 461

                        410       420
                 ....*....|....*....|....*....
gi 387537433 397 NEYKVLEIIREELTEIKERFNDERRTEIV 425
Cdd:PRK05561 462 SERKLRKLIKKELKADAKKFGDPRRTPIE 490
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 1-412 0e+00

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 648.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDT 80
Cdd:cd00187   34 EKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNFGSRDGDDAAAMRYTETRLSPIARLLLPDIDDPT 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  81 IDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIQELMEVIPGPDFPTAGQ 160
Cdd:cd00187  114 VDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLREVIDALRALIDNPEASIDELMEIIKGPDFPTGGI 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 161 ILGRSGIRKAYESGRGSITIRAKAEIEqTSSGKERIIVTELPYQVNKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRI 240
Cdd:cd00187  194 IEGRAGIREAYETGRGRYIIRGKYEIE-DDEGRNTIEITELPYQVNKAKLKEKIAELVKDKKIEGISDVRDESDREGIRF 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 241 VIEIRRDANGNVILNNLYKQTALQTSFGINLLALV-DGQPKVLNLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEG 319
Cdd:cd00187  273 VIELKRGAMAEVVLNGLYKVTKLQTTFGINMVAFDpNGRPKKLNLKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEG 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 320 LRVALDHLDAVISLIRNSqtaEIARTGLIEQF---SLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKLIGELKDILA 396
Cdd:cd00187  353 LLKAILNIDEVINLIRSS---DEAKKALIEELeklGFSEIQADAILDMRLRRLTKLEREKLLKELKELEAEIEDLEKILA 429

                        410
                 ....*....|....*.
gi 387537433 397 NEYKVLEIIREELTEI 412
Cdd:cd00187  430 SEERPKDLWKEELDEF 445
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
1-409 0e+00

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 585.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433    1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV-DGDSAAAMRYTEARMSKISMEILRDITKD 79
Cdd:pfam00521  31 YKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGSRiDGDKDAAMRYTETRLSKIARELFPDIDDD 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   80 TIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIqeLMEVIPGPDFPTAG 159
Cdd:pfam00521 111 TVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREIIDALIALLDGPEATL--LMKYIMGPDFPTGG 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  160 QILGRSGIRKAYESGRGSITIRAKAEIEQtssgKERIIVTELPYQVNKAKLIEKIADLVRDKKIEGITDLRDESDRtGMR 239
Cdd:pfam00521 189 GIIGKGGIKEAYKTGRGKITVRAKVEIED----RKTIVITELPYGVWTSDLIEKIEELVKNGKIKGISDIRDESDR-GVR 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  240 IVIEIRRDANGNVILNNLYKQTALQTSFGINLLALVDGQPKVLNLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEG 319
Cdd:pfam00521 264 IVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDGGPKYLGLKEILKEFLDHRLEVYERRKEYLLEKLEERLHILEG 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  320 LRVALDHLDAVISLIRNSQTAEIARTGLIEQfsLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKLIGELKDILANEY 399
Cdd:pfam00521 344 LLIALNNIDFVIEIIRGSIDRKKAKKNLIEE--LSEIQADYLLDMRLRRLTKEEVDKLLEEIDELEKEIAELEKLLASEK 421

                         410
                  ....*....|
gi 387537433  400 KVLEIIREEL 409
Cdd:pfam00521 422 KLNDLWIEEL 431
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 1-398 0e+00

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 564.88  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433     1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV-DGDSAAAMRYTEARMSKISMEILRDITKD 79
Cdd:smart00434  53 KVKSARGVGDVMGKYHPHGDSSLYDTIVRMAQDFSNNYPLLDGQGNFGSRlDGDDAAAMRYTETRLSPLARLLLPDIDKD 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433    80 TIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIQELMEVIPGPDFPTAG 159
Cdd:smart00434 133 TVDFVPNYDGQEIEPTVLPPIIPNLLVNGSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASIDELMMIPWGPDFPTGG 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   160 QILGRSgirkayesgrgSITIRAKAEIEqtssGKERIIVTELPYQVNKAKLIEKIADLVRDKKIEGITDLRDES-DRTGM 238
Cdd:smart00434 213 EIVGPG-----------KYVVRGKIEIE----DDNTIVITELPYQVNTADLIEKIAELVKDKKIEGIIDVRDEShDRTGV 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   239 RIVIEIRRDANGNVILNNLYKQTALQTSFGINLLALVD-GQPKVLNLKQCLEHYLDHQKVVIRRRTAYELRKAE-ARAHI 316
Cdd:smart00434 278 RIVIELKRGAMAEVVLNGLYKLTKLQTTFSINMLALFDnGRPKKYNLKEILKEFLDHRLEVYTRRKEYLLGKLEaERLHI 357

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   317 LEGLRVALDHLDAVISLIRNSQ-TAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKLIGELKDIL 395
Cdd:smart00434 358 LEGLFIALSIIDEIIVLIRSSKdLAKEAKEKLMERFELSEIQADAILDMRLRRLTKLEVEKLEKELKELEKEIEDLEKIL 437


                   ...
gi 387537433   396 ANE 398
Cdd:smart00434 438 ASE 440
PRK13979 PRK13979
DNA topoisomerase IV subunit A; Provisional
 1-425 0e+00

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 237576 [Multi-domain]  Cd Length: 957  Bit Score: 553.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDT 80
Cdd:PRK13979  68 YYKSARIVGDILGKYHPHGDSSVYDAMVILAQDFTTRMPLIDGHGNWGSIDGDSAAAMRYTEARLTPIAMEMLRDIDKDV 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  81 IDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIQELMEVIPGPDFPTAGQ 160
Cdd:PRK13979 148 VNMVDNYSDSEKEPEVLPARYPNLLVNGAFGIAVGLATNIPPHNLKEVIDGTLAYIDNNEITTKELMNYIKGPDLPTGGI 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 161 ILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEKIADLVRDKK----IEGITDLRDESDRT 236
Cdd:PRK13979 228 LIGKKSLLSAYETGEGKVTLRAKTKIEKLENGRLGIVITEFPYRRNKAKLLQTISEMTADKKhskaLENISDIRDESDRN 307

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 237 GMRIVIEIRRDAN---GNVILNNLYKQTALQTSFGINLLALVDGQPKVLNLKQCLEHYLDHQKVVIRRRTAYELRKAEAR 313
Cdd:PRK13979 308 GIRAVIEFKKSADedvAEKVLKYLYKKTDLQCNISFNMVALADGKPETMGLKTMLKHYVEHQKEVVTRRTKKELEIAEKR 387

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 314 AHILEGLRVALDHLDAVISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKLIGELKD 393
Cdd:PRK13979 388 FHIVEGFIKAIGIMDEIIKTIRSSKSKKDASENLIEKFGFTDEQAEAILELMLYRLTGLEIVAFEKEYKELEKLIKKLTK 467

                        410       420       430
                 ....*....|....*....|....*....|..
gi 387537433 394 ILANEYKVLEIIREELTEIKERFNDERRTEIV 425
Cdd:PRK13979 468 ILSSEKELLKVIKKELKEVKEKYGDERRTSII 499
parC_Gpos TIGR01061
DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II ...
 1-424 3.30e-164

DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273422 [Multi-domain]  Cd Length: 738  Bit Score: 479.68  E-value: 3.30e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433    1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDT 80
Cdd:TIGR01061  56 YKKSARTVGEIMGKYHPHGDSSIYDAMVRMSQDWKNNWTLVEMHGNNGSIDGDNAAAMRYTEARLSLIASELLKDIDKKT 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   81 IDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIQELMEVIPGPDFPTAGQ 160
Cdd:TIGR01061 136 VSFIPNFDDSEKEPTVLPALFPNLLINGATGIAAGYATNIPPHNLNEVIDALIYRIDHPNCSVDKLMEIVKGPDFPTGGI 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  161 ILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRI 240
Cdd:TIGR01061 216 IQGEDGISKAYETGKGKFIIRAKIEIEVNKNGLNQIVITEIPYETNKANIVKKIEEIIFDNKVAGIEEVRDESDRNGIRI 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  241 VIEIRRDANGNVILNNLYKQTALQTSFGINLLALVDGQPKVLNLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGL 320
Cdd:TIGR01061 296 IIELKKDANAEKILNFLFKHTDLQINYNFNMVAIANRTPIQVGLLSYLDAYIKHCHEVIINRSKYELEKASKRLEIVEGL 375

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  321 RVALDHLDAVISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKLIGELKDILANEYK 400
Cdd:TIGR01061 376 IKAISIIDEIIKLIRSSEDKSDAKENLIDNFKFTENQAEAIVSLRLYRLTNTDIFELKEEQNELEKKIISLEQIIASEKA 455

                         410       420
                  ....*....|....*....|....
gi 387537433  401 VLEIIREELTEIKERFNDERRTEI 424
Cdd:TIGR01061 456 RNKLLKKQLEEYKKQFAQQRRSQI 479
parC_Gneg TIGR01062
DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II ...
 1-425 1.34e-151

DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 130134 [Multi-domain]  Cd Length: 735  Bit Score: 447.43  E-value: 1.34e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433    1 YKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDG-DSAAAMRYTEARMSKISMEILRDITKD 79
Cdd:TIGR01062  56 YKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDpKSFAAMRYTESRLSKISELLLEELGQG 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   80 TIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIQELMEVIPGPDFPTAG 159
Cdd:TIGR01062 136 TVDFRPNFDGTLLEPVILPARLPNILLNGTTGIAVGMATDIPPHNLHELADAALYLIDNPKAGLDDILNIVQGPDFPTEA 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  160 QILG-RSGIRKAYESGRGSITIRAKAEIEQTSsgkerIIVTELPYQVNKAKLIEKIADLVRDKKIEGITDLRDESDRTG- 237
Cdd:TIGR01062 216 EIIDkAEEIRKIYETGRGSFRMRARWKKEDGQ-----IVISALPHQISKSKVIEQIAIQMKDKKLPMISDIRDESDHENp 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  238 MRIVIEIR-RDANGNVILNNLYKQTALQTSFGINLLAL-VDGQPKVLNLKQCLEHYLDHQKVVIRRRTAYELRKAEARAH 315
Cdd:TIGR01062 291 IRVVIVPRsNRVDPDIVMEHLFATTDLEKSYRLNMNMIgLDNVPAVKNLLEILQEWLVFRRNTVIRRLTYRLNKVLQRLH 370

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  316 ILEGLRVALDHLDAVISLIRNSQTaeiARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKLIGELKDIL 395
Cdd:TIGR01062 371 ILEGLRIAFLNIDEVIEIIREEDE---PKTILMERFKLSAIQAEAILNLRLRHLAKLEEHAIIDEQSELEKERAILEKIL 447

                         410       420       430
                  ....*....|....*....|....*....|
gi 387537433  396 ANEYKVLEIIREELTEIKERFNDERRTEIV 425
Cdd:TIGR01062 448 KSERELNQLVKKEIQADATKYGLARRSSLE 477
PRK09631 PRK09631
DNA topoisomerase IV subunit A; Provisional
 3-424 1.94e-52

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 236598 [Multi-domain]  Cd Length: 635  Bit Score: 185.68  E-value: 1.94e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   3 KSARIVGEVIgKYHPHGDSAVYESMVRMAQdfnyRYMLVDGHGNFGSV-DGDSAAAMRYTEARMSKISMEIL--RDITkd 79
Cdd:PRK09631  53 KVANVVGNTM-KYHPHGDASIYEALVNLAN----KDLFIDKQGNFGNLfTGDPASAARYIECRLTPLAKEVLynKEIT-- 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  80 tiDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIQelmevipgPDFPTAG 159
Cdd:PRK09631 126 --EYEPSYDGRNNEPLCLPAKIPVILIQGAEGIAVGMATKILPHNFNEILQAVKSELLGESFALY--------PDFPTGG 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 160 qILGRSGirkaYESGRGSITIRAKAEIeqtsSGKERIIVTELPYQVNKAKLIEKIADLVRDKKIEgITDLrdeSDRTGMR 239
Cdd:PRK09631 196 -IVDVSE----YADGNGKVLVRAKIET----KDEKTIVIREIPFGTTTESLIASIEKAARKGKIK-ISSI---NDYTAEN 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 240 IVIEIR--RDANGNVILNNLYKQTALQTSFGINLLALVDGQPKVLNLKQCLEHYLDHQKVVIRRRTAYELRKAEARAH-- 315
Cdd:PRK09631 263 VEIEIKlpRGVYASEVIEALYAYTDCEVSISVNLLVIKDRYPVIYTVTDIIKFHAEHLQKVLKMELELERAKLLEKIFak 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 316 -------------ILEGLRVALDHLDAVISLIRnSQTAEIARtglieqfSLTEKQAQAILDMRLQRLTGLEREKIEEEYQ 382
Cdd:PRK09631 343 tleqifieeriykRIETISSEEDVISIVLSELK-PFKEELSR-------DVTEEDIENLLKIPIRRISLFDIDKNQKEIR 414

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 387537433 383 SLVKLIGE----LKDILANEYKVLEIIREELTEIKerfndERRTEI 424
Cdd:PRK09631 415 ILNKELKSveknLKSIKGYAINFIDKLLAKYSKEY-----PRKTEI 455
PRK12758 PRK12758
DNA gyrase/topoisomerase IV subunit A;
1-424 6.11e-48

DNA gyrase/topoisomerase IV subunit A;


Pssm-ID: 237192 [Multi-domain]  Cd Length: 869  Bit Score: 175.58  E-value: 6.11e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   1 YKKSARIVGEVIgKYHPHGDSAVYESMVRMAQdfnyRYMLVDGHGNFGSV-DGDSAAAMRYTEARMSKISMEILrdITKD 79
Cdd:PRK12758  70 YNKVANVVGHTM-QYHPHGDASIGDALVQLGQ----KDLLIDTQGNWGNIlTGDGAAAPRYIEARLSKFALEVV--FNPK 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  80 TIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIQelmevipgPDFPTAG 159
Cdd:PRK12758 143 TTEWQLSYDGRKKEPVTLPVKFPLLLAQGAEGIAVGLSTKILPHNFNELIDASIAYLKGKEFKLY--------PDFPTGG 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 160 qILGRSgirkAYESGR--GSITIRAKaeIEQTSsgKERIIVTELPYQVNKAKLIEKIADLVrDK---KIEGITDLRDEsd 234
Cdd:PRK12758 215 -IIDVS----NYNDGErgGRVRVRAK--IEKLD--KKTLVITEIPYGTTTSSLIDSILKAN-DKgkiKIKKVEDNTAA-- 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 235 rtGMRIVIEIRRDANGNVILNNLYKQTALQTSFGINLLALVDGQPKVLNLKQCLEHYLDHQKVVIRRRTAYELRKAEARA 314
Cdd:PRK12758 283 --DVEILVHLAPGVSPDKTIDALYAFTDCEVSISPNACVIIDNKPHFLGVSDILRRSTDHTVSLLKQELEIRLSELEEQW 360

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 315 HI--LEGL----RVALD-----HLDAVISLIRNSQTAEIARtgLIEQfsLTEKQAQAILDMRLQRLTGLEREKIEEEYQS 383
Cdd:PRK12758 361 HFasLEKIfieeRIYKEieeaeTWEAVIEAIDKGLEPFKKQ--FIRE--VTEDDIVRLTEIKIKRISKFDSDKADELIAR 436

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 387537433 384 LVKLIGELKDILAN--EYKVleiirEELTEIKERF--NDERRTEI 424
Cdd:PRK12758 437 LEAEIAEVKHHLAHltDYAI-----AYFTNLKKKYgkGRERKTEI 476
PRK09630 PRK09630
DNA topoisomerase IV subunit A; Provisional
 3-307 7.28e-35

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 170022  Cd Length: 479  Bit Score: 135.02  E-value: 7.28e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   3 KSARIVGEVIGkYHPHGDSAVYESMVRMAqdfNYRYmLVDGHGNFGS-VDGDSAAAMRYTEARMSKISMEILrdITKDTI 81
Cdd:PRK09630  53 KVANIAGRTMA-LHPHGDAPIVEALVVLA---NKGY-LIDTQGNFGNpLTGDPHAAARYIEARLSPLAKEVL--FNTDLM 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  82 DYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIQelmevipgPDFPTAGQI 161
Cdd:PRK09630 126 TFHDSYDGREKEPDILPAKLPLLLLHGVDGIAVGMTTKIFPHNFCELLEAQIAILNDQPFTLL--------PDFPSGGTM 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 162 LGRSgirkaYESGRGSITIRAKAEIEQTSSgkerIIVTELPYQVNKAKLIEKIADLVRDK--KIEGITDLRDESDrtgmR 239
Cdd:PRK09630 198 DASE-----YQDGLGSITLRASIDIINDKT----LLIKEICPSTTTETLIRSIENAAKRGiiKIDSIQDFSTDLP----H 264

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 387537433 240 IVIEIRRDANGNVILNNLYKQTALQTSFGINLLALVDGQP------KVLNLK-QCLEHYLDHQKVVIRRRTAYEL 307
Cdd:PRK09630 265 IEIKLPKGIYAKDLLRPLFTHTECQVILTSRPTAIYQNKPvetsisEILRLHtETLQGYLKKELLILEDSLSREH 339
52 PHA02592
DNA topisomerase II medium subunit; Provisional
 1-392 4.61e-32

DNA topisomerase II medium subunit; Provisional


Pssm-ID: 222896 [Multi-domain]  Cd Length: 439  Bit Score: 126.32  E-value: 4.61e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   1 YKKSARIVGEV-IGKYHpHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSkismEILRDITKD 79
Cdd:PHA02592  58 FDKVAAIAGGVaDLGYH-HGETSAQDAGALMANTWNNNIPLLDGQGNFGSRLVQKAAAARYIFARVH----DNFRKIYKD 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  80 tIDYQDNYDGSERepvvMPSRF-----PNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITiqelmevIPGPD 154
Cdd:PHA02592 133 -EDLAPVHEDPEH----IPPAFylpiiPMVLLNGVSGIATGYATNILPHSPKSVIKAVLAALNGKDIT-------EPKVQ 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 155 FPtagqilGRSGirKAYESGRGSITIRAKAEIeqtsSGKERIIVTELPYQVNKAKLIEKIADLVRDKKIEGITDLRDEsd 234
Cdd:PHA02592 201 FP------EFKG--EVVEIEPGSYEIRGTYEL----NGKTKLHITEIPVKYDRETYVAVLDPLEEKGKIVSYDDCTED-- 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 235 rtGMRIVIEIRRDANGNVILNNLYKQTALQTSFGINLLALV-DGQPKVL-NLKQCLEHYLDHQKVVIRRR-------TAY 305
Cdd:PHA02592 267 --GFRFKVTLKREENEEATHEKIMKDFGLIERVSQNITVINeNGKLKVYeNAEDLIRDFVEIRKTYVQKRiqyeikeTEE 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433 306 ELRKAEARAHILEglrvalDHLDAVISL---IRNSQTAEIArtglieQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQ 382
Cdd:PHA02592 345 AFDLALAKAEFIK------RVIAGEIVLqgkTRSELTEELS------DNKDFGEYADKLVAMNIYSMTSDEREKLQKEAE 412

                        410
                 ....*....|
gi 387537433 383 SLVKLIGELK 392
Cdd:PHA02592 413 ELEKEHEYWK 422
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 15-426 1.34e-16

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 82.40  E-value: 1.34e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   15 YHpHGDSAVYESMVRMAQDF----NYRYMLVDGHgnFGS--VDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNyD 88
Cdd:PTZ00108  724 YH-HGEQSLQQTIVGMAQNFvgsnNINLLYPCGQ--FGSrlQGGKDHAAARYIFTKLSKITRYIFPEEDDPILDYLED-D 799

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   89 GSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENpditiQELMEVIPgpdfptagqilgrsgir 168
Cdd:PTZ00108  800 GQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNLRRRLNG-----EEVRPLVP----------------- 857

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  169 kAYESGRGSITIRAKAEIEqtSSGK------ERIIVTELPYQV---NKAKLIEKIAdlvrDKKIEGITDLRDESDRTGMR 239
Cdd:PTZ00108  858 -WYRGFKGTIERNPKGKFI--SKGIyekvpdGTVEITELPIGKwteDYKEFLESET----LKEKDVIVDYRDYSTANTVH 930

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  240 IVIEIRRDANGNVILNNLYKQTALQTSFGINLLALVDGQ---PKVLNLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHI 316
Cdd:PTZ00108  931 FTVKLNDGVLEQWEEEGIEKVFKLKSTISTTNMVLFDENgkiKKYSDALDILKEFYLVRLDLYKKRKEYLLGKLERELAR 1010

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  317 LEG-----LRVALDHL-------DAVIS------LIRNSQTAEIARTGLIEQFSLTEKQAQA------------------ 360
Cdd:PTZ00108 1011 LSNkvrfiKHVINGELvitnakkKDLVKelkklgYVRFKDIIKKKSEKITAEEEEGAEEDDEaddeddeeelgaavsydy 1090

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 387537433  361 ILDMRLQRLTgLER-EKIEEEYQSLVKLIGELKDIlaneyKVLEIIREELTEIKERFNDERRTEIVT 426
Cdd:PTZ00108 1091 LLSMPIWSLT-KEKvEKLNAELEKKEKELEKLKNT-----TPKDMWLEDLDKFEEALEEQEEVEEKE 1151
PLN03128 PLN03128
DNA topoisomerase 2; Provisional
 15-319 1.44e-16

DNA topoisomerase 2; Provisional


Pssm-ID: 215593 [Multi-domain]  Cd Length: 1135  Bit Score: 82.45  E-value: 1.44e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   15 YHpHGDSAVYESMVRMAQDF---NYRYMLVDgHGNFGS--VDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNyDG 89
Cdd:PLN03128  717 YH-HGEASLASTIIGMAQDFvgsNNINLLTP-SGQFGTrlQGGKDAASARYIFTRLSPITRALFPKDDDVLLNYLNE-DG 793

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   90 SEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDitiQELMEvipgpdfPTAGQILGRsgIRK 169
Cdd:PLN03128  794 QSIEPEWYCPIIPMVLVNGSEGIGTGWSTFIPNYNPRDIIANIRRLLRGEE---LEPMH-------PWYRGFKGT--ITE 861

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  170 AYESGRGSITIRAKAEIEQTSSgkerIIVTELPYQV---NKAKLIEKIADLVRDKKIEgITDLRDESDRTGMRIVIEIRR 246
Cdd:PLN03128  862 VSTSRSGSYTVTGIIEQIGDTT----IRITELPVRKwtqDYKEFLEALLTGTKKKEPE-IKDFKENHTDTTVHFTVTLSE 936

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  247 DANGNVILNNLYKQTALQTSFGINLLALVDGQPKVLNLK---QCLEHYLDH-------QKVVIRRRTAYELRKAEARAHI 316
Cdd:PLN03128  937 EKMARALAEGLEKKFKLSTTISTSNMHLFDKDGKIKKYDspeDILEEFFHLrldlyvkRKEVLLENLEYELKKLDNKARF 1016


                  ...
gi 387537433  317 LEG 319
Cdd:PLN03128 1017 ILA 1019
PLN03237 PLN03237
DNA topoisomerase 2; Provisional
 3-310 6.54e-10

DNA topoisomerase 2; Provisional


Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 61.42  E-value: 6.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433    3 KSARIVGEV--IGKYHpHGDSAVYESMVRMAQDF---NYRYMLVDGhGNFG--SVDGDSAAAMRYTEARMSKISMEILRD 75
Cdd:PLN03237  728 KVAQLSGYVseHSAYH-HGEQSLASTIIGMAQDFvgsNNINLLLPN-GQFGtrLQGGKDHASARYIFTRLSPITRFLFPK 805

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433   76 ITKDTIDYQDNyDGSEREPV-VMPSrFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENpditiqELMEvipgPD 154
Cdd:PLN03237  806 DDDILLDYLNE-DGQSIEPTwYMPI-IPTVLVNGAEGIGTGWSTFIPNYNPRDIVANIRRLLNG------ESME----PM 873

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  155 FPTagqilgrsgirkaYESGRGSI--TIRAKAEIEQTSSGK------ERIIVTELP---YQVNKAKLIEKIADLVRDKKI 223
Cdd:PLN03237  874 HPW-------------YRGFKGTIekTASKEGGCTYTITGLyeevdeTTLRITELPirrWTDDYKEFLESLKTDNNKNKD 940

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387537433  224 EGITDLRDESDRTGMRIVIEIRRDANGNVILNNLYKQTALQTSFGINLLALVD---GQPKVLNLKQCLEHYLDhqkvviR 300
Cdd:PLN03237  941 PFIKDVKAYNDDTTVHFEVILSEENMLAAKQEGLLKKFKLTTTISTSNMHLFDskgVIKKYDTPEQILEEFFH------L 1014

                         330
                  ....*....|
gi 387537433  301 RRTAYELRKA 310
Cdd:PLN03237 1015 RLEYYEKRKE 1024
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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