|
Name |
Accession |
Description |
Interval |
E-value |
| AAA_6 |
pfam12774 |
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ... |
1862-2188 |
0e+00 |
|
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.
:
Pssm-ID: 463697 [Multi-domain] Cd Length: 327 Bit Score: 627.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1862 YFYEYLGNSPRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGTGKTETTKDLGRALGMMVYVFNCSEQMDYKSIGNIYKG 1941
Cdd:pfam12774 1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1942 LVQTGAWGCFDEFNRISVEVLSVVAVQVKMIHDAIRNRKKRFVFLGEAITLKPSVGIFITMNPGYAGRTELPENLKALFR 2021
Cdd:pfam12774 81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2022 PCAMVAPDIELICEILLVAEGFVDARALARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVLM 2101
Cdd:pfam12774 161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSNPNLNEDVLLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2102 RALRDFNMPKIVTDDIPVFLGLVGDLFPALDVPRRRKLHFEQMVRQSTLELRLQPEESFILKVVQLEELLAVRHSVFVVG 2181
Cdd:pfam12774 241 RALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLVRHGVMLVG 320
|
....*..
gi 225131082 2182 NAGTGKS 2188
Cdd:pfam12774 321 PTGSGKT 327
|
|
| DHC_N1 |
pfam08385 |
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ... |
240-812 |
0e+00 |
|
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.
:
Pssm-ID: 462457 Cd Length: 560 Bit Score: 626.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 240 LHAIESVVIEWSHQIQEIIERDSvqrllNGLHLSPQAELDFWMMRRENLSCIYDQLQAPVVLKMVKILTTKQSSYFPTLK 319
Cdd:pfam08385 1 LHALESVVIKWTKQIQDVLKEDS-----QGRNPGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 320 DIFLAVENALLEAQDVELYLRPLRRHIQCLQE-TEFPQTRILIAPLFHTICLIWSHSKFYNTPARVIVLLQEFCNLFINQ 398
Cdd:pfam08385 76 ALDTELTDALNEAKDNVKYLKTLERPFEDLEElTDPPEIIEAIPPLMNTIRLIWSISRYYNTSERMTVLLEKISNQLIEQ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 399 ATAYLSPEDLLRGEIEESLEKVQVAVNILKTFKNSFFNYRKKLASYFMGRklrPWDFQSHLVFCRFDKFLDRLIKIEDIF 478
Cdd:pfam08385 156 CKKYLSPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEESPRER---PWDFSERYIFGRFDAFLERLEKILELF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 479 ATTLEFEKLERLefGGTKGAILNGQVHEMSEELMELCKLFKQSTYDPSDCTNMEFESDYVAFKSKTLEFDRRLGTIICEA 558
Cdd:pfam08385 233 ETIEQFSKLEKI--GGTKGPELEGVIEEILEEFQEAYKVFKSKTYDILDVSNEGFDDDYEEFKERIKDLERRLQAFIDQA 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 559 FFNCNGLEAAFKLLTIFGNFLEKPVVMEIFSLHYSTLVHMFNTELDVCKQLYNEHMKQiecgHVVLNKNMPFTSGNMKWA 638
Cdd:pfam08385 311 FDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQKYN----PSPIAKNMPPVAGAIIWA 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 639 QQVLQRLQMFWSNFASLRYLfLGNPDHALVYQKYVEMTTLLDQFESRIYNEWKSNVDEICEFNLNQPL-VKFSAINGLLC 717
Cdd:pfam08385 387 RQLFRRIQEPMKRFKEELGL-LKHAEGKKVIKKYNELAKKLDEYERLIYEAWLKEVEEASEGNLKRPLlVRHPETGKLLS 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 718 VNFDPKLVAVLREVKYLLMLkKQDIPDSALAIFKKRNTILKYIGNLDLLVQGYNKLKQTLLEVEYPLIEDELRAIDEQLT 797
Cdd:pfam08385 466 VNFDPQLLALLREVKYLQKL-GFEIPESALNIALKEERLRPYAESLELLVRWYNKIRSTLLPVERPLLAPHLKDIDEKLE 544
|
570
....*....|....*.
gi 225131082 798 AATTWLTWQDD-CWGY 812
Cdd:pfam08385 545 PGLTTLTWNSLgIDEY 560
|
|
| MT super family |
cl37598 |
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ... |
3104-3448 |
1.07e-169 |
|
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.
The actual alignment was detected with superfamily member pfam12777:
Pssm-ID: 463699 [Multi-domain] Cd Length: 344 Bit Score: 526.95 E-value: 1.07e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3104 ERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIGLQTEKVSREKTIADAEERKVTAIQTEVFQKQREC 3183
Cdd:pfam12777 1 ERLENGLLKLHSTAAQVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQKAC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3184 EADLLKAEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLAPRGRVPKDRSWKAAKVFMGKVDDFLQALI 3263
Cdd:pfam12777 81 EEDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILMAPGGKIPKDKSWKAAKIMMAKVDGFLDSLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3264 NYDKEHIPENCLKVVNEhYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCDVEPKRQALAQANLELAAATEKLEA 3343
Cdd:pfam12777 161 KFDKEHIHEACLKAFKP-YLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQALEEANADLAAAQEKLAA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3344 IRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQSIKSFEAQEKTLCGDVLLTAA 3423
Cdd:pfam12777 240 IKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQERTLCGDILLISA 319
|
330 340
....*....|....*....|....*
gi 225131082 3424 FVSYVGPFTRQYRQELVHCKWVPFL 3448
Cdd:pfam12777 320 FISYLGFFTKKYRNELLDKFWIPYI 344
|
|
| DHC_N2 |
pfam08393 |
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ... |
1316-1726 |
3.03e-151 |
|
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.
:
Pssm-ID: 462462 [Multi-domain] Cd Length: 402 Bit Score: 476.75 E-value: 3.03e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1316 MKQCRKEIKLLKGLWDVIIYVRRSIDNWTKTQWRQIHVEQMDVELRRFAKassitEIWSLNKEVRVWDAYTGLEGTVKDM 1395
Cdd:pfam08393 1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLK-----ELKKLPKELRDWDVAEELKKKIDDF 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1396 TASLRAITELQSPALRDRHWHQLMKAIGVKFL-INEATTLADLLALRLHRVEDDVRRIVDKAVKELGTEKVITEISQTWA 1474
Cdd:pfam08393 76 KKSLPLIEDLRNPALRERHWKQLSEILGFDFDpLSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1475 TMKFSYEVHYRTGIPLLKSDEQLFETLEHNQVQLQTLLQSKYVEYFIEQVLSWQNKLNIADLVIFTWMEVQRTWSHLESI 1554
Cdd:pfam08393 156 TMEFELVPYKDTGTFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1555 FVcSEDIRIQLVKDARRFDGVDAEFKELMFKTAKVENVLEATCRPNLYEKLKDLQSRLSLCEKALAEYLETKRIAFPRFY 1634
Cdd:pfam08393 236 FS-SEDIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFY 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1635 FVSSADLLDILSKGAQPKQVTCHLAKLFDSIADLQFEDNQDVsahraVGMYSKEKEYVPF-QAECECVGHVETWLLQLEQ 1713
Cdd:pfam08393 315 FLSNDELLEILSQTKDPTRVQPHLKKCFEGIASLEFDENKEI-----TGMISKEGEVVPFsKPPVEAKGNVEEWLNELEE 389
|
410
....*....|...
gi 225131082 1714 TMQETVRHSITEA 1726
Cdd:pfam08393 390 EMRETLRDLLKEA 402
|
|
| Dynein_C |
pfam18199 |
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ... |
4226-4508 |
3.87e-112 |
|
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.
:
Pssm-ID: 465677 Cd Length: 301 Bit Score: 360.01 E-value: 3.87e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 4226 TVTSNTLFRTLLEMQPRNALSGDELGQSTEEKVKNVLDDILEKLPEEFNMAEIMQK--NSNRSPYVLVCFQECERMNILI 4303
Cdd:pfam18199 1 TNETNELLSTLLSLQPRSDSGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKypVGYEDPLNTVLLQEIERFNKLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 4304 REIRISLEQLDLSLKGELALSPAVEAQQFALSYDTVPDTWSKLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWL 4383
Cdd:pfam18199 81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLDDEGPPKVFWL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 4384 SGFFNPQSFLTAIMQTMARKNEWPLDKTRLTADVTKK-TKEDYGHPPREGAYLHGLFMEGARWDTQAGTIVEARLKELAC 4462
Cdd:pfam18199 161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKvSPEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 225131082 4463 PMPVIFAKATPVDRQETKQ-TYECPVYRTKLRG-PSYIWTFRLKSEEK 4508
Cdd:pfam18199 241 PLPVIHLKPVESDKKKLDEnTYECPVYKTSERHsTNFVFSVDLPTDKP 288
|
|
| DYN1 super family |
cl34955 |
Dynein, heavy chain [Cytoskeleton]; |
1548-4173 |
1.33e-110 |
|
Dynein, heavy chain [Cytoskeleton];
The actual alignment was detected with superfamily member COG5245:
Pssm-ID: 227570 [Multi-domain] Cd Length: 3164 Bit Score: 398.59 E-value: 1.33e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1548 WSHLESIFVCSEDIRIQLVKDARRFDGVDAEFKELMFKTAKVENVLEATCRPNlYEKLKDLQSRLSLCEKALAEYLETKR 1627
Cdd:COG5245 627 RLDEYLMMMSLEDLMPLIPHAVHRKMSLVSGVRGIYKRVVSGCEAINTILEDV-GDDLDLFYKEMDQVFMSIEKVLGLRW 705
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1628 IAFPRFYFVSsaDLLDILSKGAQPKQVTCHLAKLFDSIADLQFednqdvsahravgMYSKEKEYVPFQAECEcvGHVETW 1707
Cdd:COG5245 706 REVERASEVE--ELMDRVRELENRVYSYRFFVKKIAKEEMKTV-------------FSSRIQKKEPFSLDSE--AYVGFF 768
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1708 LLQLEQTMQETVRHSITEAIVAYEEKPRELwiFDFPAQVALTSSQIWwtTDVGIAFSRLEEGYETALKDFHKKQISQLNT 1787
Cdd:COG5245 769 RLYEKSIVIRGINRSMGRVLSQYLESVQEA--LEIEDGSFFVSRHRV--RDGGLEKGRGCDAWENCFDPPLSEYFRILEK 844
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1788 LITLLLGELPPGDRQKIMTICTIDVHARDVVAKLisQKKVVVSPQAFTWLSqLRHRWEDTQKHCFVNICDAQFQYFYEYL 1867
Cdd:COG5245 845 IFPSEEGYFFDEVLKRLDPGHEIKSRIEEIIRMV--TVKYDFCLEVLGSVS-ISELPQGLYKRFIKVRSSYRSAEMFAKN 921
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1868 GNSPRLVITPLTDRCYITLTQSLHLTMSGApagpAGTGKTETTKDLGRALGMMVyvfncsEQMDYKSigNIYKGLVQTGA 1947
Cdd:COG5245 922 TIPFFVFEHSMDTSQHQKLFEAVCDEVCRF----VDTENSRVYGMLVAGKGRIY------DGTEPRS--RIEAGPICEEE 989
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1948 WGcFDEFNRISvEVLSVVAVQVKMIHDAIRNRKKRFVFLGEAITLKPSVGIFITMNPgyagRTELPENLKALFRPCAMVA 2027
Cdd:COG5245 990 RG-TEESALLD-EISRTILVDEYLNSDEFRMLEELNSAVVEHGLKSPSTPVEMIINE----RNIVLEIGRRALDMFLSNI 1063
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2028 P-------DIELICEILLVAEgFVDARALARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVL 2100
Cdd:COG5245 1064 PfgaiksrRESLDREIGAFNN-EVDGIAREEDELMFYPMFKSLKAKHRMLEEKTEYLNKILSITGLPLISDTLRERIDTL 1142
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2101 MRALRDFNMPKIVtddipvflglvgdlFPALDVPRRRKLHFEQMVRQstleLRLQPEESFILKVvqleellavrhsvfvv 2180
Cdd:COG5245 1143 DAEWDSFCRISES--------------LKKYESQQVSGLDVAQFVSF----LRSVDTGAFHAEY---------------- 1188
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2181 GNAGTGKSKILRTL-------NRTYVnmkqkpvwndlnpkavtTDELFgfihHATREWKdgkivysyfiGLFSSILRE-- 2251
Cdd:COG5245 1189 FRVFLCKIKHYTDAcdylwhvKSPYV-----------------KKKYF----DADMELR----------QFFLMFNREdm 1237
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2252 QANLKhDGPKWIVLDGdidpmWIESLNTVMDDNKVLTLASNERialtpfmRLLFEihHLRSaTPATVSRAGILY------ 2325
Cdd:COG5245 1238 EARLA-DSKMEYEVER-----YVEKTKAEVSSLKLELSSVGEG-------QVVVS--NLGS-IGDKVGRCLVEYdsisrl 1301
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2326 ----VNPQDLG-WNPYVASWIDRRRHQSEKANLTILFDkyVPACLDKLRTSFKTITSIPESSLVQTLCVLL--ECLLTP- 2397
Cdd:COG5245 1302 stkgVFLDELGdTKRYLDECLDFFSCFEEVQKEIDELS--MVFCADALRFSADLYHIVKERRFSGVLAGSDasESLGGKs 1379
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2398 ----ENVPSDSPKEVYEVYFVFACIWAFGGtllqDQISDYQADFSRW----WQKEMKAVKFPSQGTIFDYYVDHKTKKLL 2469
Cdd:COG5245 1380 ielaAILEHKDLIVEMKRGINDVLKLRIFG----DKCRESTPRFYLIsdgdLIKDLNERSDYEEMLIMMFNISAVITNNG 1455
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2470 PwadkIAQFTMDPDVPL--QTVLVHTTETARLRYFMELLLEKGKPLMLVGNAGVGKTVFVGDTLASlSEDYIVSRVPFNY 2547
Cdd:COG5245 1456 S----IAGFELRGERVMlrKEVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSLRS-ELITEVKYFNFST 1530
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2548 YTTSTALQKILEKPLEK----KAGHNYGPGGNKKLIYFIDDMNMPEVDLYGTVQPHTLIRQHIDYGHWYDRQKVMLKEIH 2623
Cdd:COG5245 1531 CTMTPSKLSVLERETEYypntGVVRLYPKPVVKDLVLFCDEINLPYGFEYYPPTVIVFLRPLVERQGFWSSIAVSWVTIC 1610
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2624 NCQYVACMNP--MVGSFTISPRLQRHfTVFAF-NFPSLDALNTIYGQIFSFHFQqqaFAPSILRSGPTLIQATIAFHQTM 2700
Cdd:COG5245 1611 GIILYGACNPgtDEGRVKYYERFIRK-PVFVFcCYPELASLRNIYEAVLMGSYL---CFDEFNRLSEETMSASVELYLSS 1686
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2701 MCNFlPTAIKFHYIFNLRDLSNVFQGILFASPECLKGP-LDLIHLWLHESARVYGDKLIDKKDCDLFQRRMLETAYKYFE 2779
Cdd:COG5245 1687 KDKT-KFFLQMNYGYKPRELTRSLRAIFGYAETRIDTPdVSLIIDWYCEAIREKIDRLVQQKESSTSRQDLYDFGLRAIR 1765
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2780 GID-SH---------MLLQQPLIYCHFADrgkdphyMPVKDWEVLKTILTETLDNynelnaamHLVLFEDAMQHVCRISR 2849
Cdd:COG5245 1766 EMIaGHigeaeitfsMILFFGMACLLKKD-------LAVFVEEVRKIFGSSHLDV--------EAVAYKDALLHILRSRR 1830
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2850 ILRTPQGCALLVGVGGSGKQSLSRLAAYLRGLEVFQITLTEGYGIQELRVDLANLYIRTGAKNMPTVFLLTDAQVLDESF 2929
Cdd:COG5245 1831 GLLVVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVESSF 1910
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2930 LVLINDLLASGEIPDLFSDEDVDKIISGIHNEVHALGM-VDSRENCWKFFMARVRLQLKIILCFSPVGRTLRVRARKFPA 3008
Cdd:COG5245 1911 LEDFNPLLDNNRFLCLFSGNERIRIPENLRFVFESTSLeKDTEATLTRVFLVYMEENLPVVFSACCSQDTSVLAGIRSPA 1990
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3009 IVNCTAIDWFHAWPQEALVSVSRRFIEETKGIEPVHKDS--------ISLFMAHVHTTVNEMSTRYYQNERR-HNYTTPK 3079
Cdd:COG5245 1991 LKNRCFIDFKKLWDTEEMSQYANSVETLSRDGGRVFFINgelgvgkgALISEVFGDDAVVIEGRGFEISMIEgSLGESKI 2070
|
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3080 SFLEQISLFKNLLKKKQNEVSEKKERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIgLQTEKVSREK 3159
Cdd:COG5245 2071 KFIGGLKVYDARCVIYIEELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGT-PGERLEREVK 2149
|
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3160 TIADAEERKVTAIQTEVFQKQRECEADLLK-AEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLaprGR 3238
Cdd:COG5245 2150 SVFVEAPRDMLFLLEEEVRKRKGSVMKFKSsKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLL---GF 2226
|
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3239 VPKDrsWKAAKVFMgKVDDFLQALINYDKE-HIPENCLKVVNEHYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVY 3317
Cdd:COG5245 2227 EAKI--WFGEQQSL-RRDDFIRIIGKYPDEiEFDLEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVL 2303
|
1850 1860 1870 1880 1890 1900 1910 1920
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3318 CDVEPKRQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKK 3397
Cdd:COG5245 2304 EVKIPLREEEKRIDGEAFLVEDRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVSEILINED 2383
|
1930 1940 1950 1960 1970 1980 1990 2000
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3398 IRWGQSIKSFEAQEKTLCGDVLLTAAFVSYVGPFTRQYRQ-ELVHCKwvPFLQQKVSIP-------LTEGLDLISmltDD 3469
Cdd:COG5245 2384 SEWGGVFSEVPKLMVELDGDGHPSSCLHPYIGTLGFLCRAiEFGMSF--IRISKEFRDKeirrrqfITEGVQKIE---DF 2458
|
2010 2020 2030 2040 2050 2060 2070 2080
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3470 ATIAAWNNEGLPSDRMSTENAAILthcerwPLVIDPQQQGIKWIKNKYgmDLKVTHLG---QKGFLNAIETALAFGDVIL 3546
Cdd:COG5245 2459 KEEACSTDYGLENSRIRKDLQDLT------AVLNDPSSKIVTSQRQMY--DEKKAILGsfrEMEFAFGLSQARREGSDKI 2530
|
2090 2100 2110 2120 2130 2140 2150 2160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3547 IENlEETIDPVLDPLLGRNTIKKGKYIR--IGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLL 3624
Cdd:COG5245 2531 IGD-AEALDEEIGRLIKEEFKSNLSEVKvmINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEIP 2609
|
2170 2180 2190 2200 2210 2220 2230 2240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3625 AEVVSIERPDLEKLKLVLTKHQNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEIEHKVIEAKENERK 3704
Cdd:COG5245 2610 DALEKLVSGPLFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIEDR 2689
|
2250 2260 2270 2280 2290 2300 2310 2320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3705 INEARECYRPLAARASLLYFVINDLQKINPLYQFSLKAFNVLFHRaieqadkVEDMQGRISILMESITHAVFLYtsqaLF 3784
Cdd:COG5245 2690 IDALKSEYNASVKRLESIRVEIAMFDEKALMYNKSICELSSEFEK-------WRRMKSKYLCAIRYMLMSSEWI----LD 2758
|
2330 2340 2350 2360 2370 2380 2390 2400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3785 EKDKLTFLSQMAFQILLRKKEIdpleLDFLLRFTVEHTHLSpvdfltSQSWSAIKAIAvmEEFRGIDRDVEGSAKQWRkW 3864
Cdd:COG5245 2759 HEDRSGFIHRLDVSFLLRTKRF----VSTLLEDKNYRQVLS------SCSLYGNDVIS--HSCDRFDRDVYRALKHQM-D 2825
|
2410 2420 2430 2440 2450 2460 2470 2480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3865 VESECPEKEKLPQ-EWKKKSLIQKLILLRamrpdrmtyalrnFVEEKLGAKYvertrlDLVKAFEESSPAT-PIFFILSP 3942
Cdd:COG5245 2826 NRTHSTILTSNSKtNPYKEYTYNDSWAEA-------------FEVEDSGDLY------KFEEGLLELIVGHaPLIYAHKK 2886
|
2490 2500 2510 2520 2530 2540 2550 2560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3943 GVDALKDLEILGKRlgftidsgkfhnvslgqGQETVAEVALEKASKGGHWVILQNVHLVAKWLGTLEKLLERFSQGSHRD 4022
Cdd:COG5245 2887 SLENERNVDRLGSK-----------------ENEVYAVLNSLFSRKEKSWFEVYNISLSFGWFKRYVEDVVYPIKASRVC 2949
|
2570 2580 2590 2600 2610 2620 2630 2640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 4023 YRVFMSAESAPTPDEHIIPQGLLENSIKITNEPPTG-MLANLHAALYnFDQDTLEICSKEqefksILFSLCYFHACVAGR 4101
Cdd:COG5245 2950 GKVKNMWTSMVDADMLPIQLLIAIDSFVSSTYPETGcGYADLVEIDR-YPFDYTLVIACD-----DAFYLSWEHAAVASV 3023
|
2650 2660 2670 2680 2690 2700 2710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225131082 4102 LRFGPQGWSRSYPFNPGDLTICASVLYNYLEANS--KVPWEDLRYLFGEIMYGGHITDDWD----RKLCRVYLEEFVN 4173
Cdd:COG5245 3024 ISAGPKENNEEIYFGDKDFEFKTHLLKNILFLNHlnARKWGNNRDLIFTIVYGKKHSLMEDskvvDKYCRGYGAHETS 3101
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| AAA_6 |
pfam12774 |
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ... |
1862-2188 |
0e+00 |
|
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.
Pssm-ID: 463697 [Multi-domain] Cd Length: 327 Bit Score: 627.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1862 YFYEYLGNSPRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGTGKTETTKDLGRALGMMVYVFNCSEQMDYKSIGNIYKG 1941
Cdd:pfam12774 1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1942 LVQTGAWGCFDEFNRISVEVLSVVAVQVKMIHDAIRNRKKRFVFLGEAITLKPSVGIFITMNPGYAGRTELPENLKALFR 2021
Cdd:pfam12774 81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2022 PCAMVAPDIELICEILLVAEGFVDARALARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVLM 2101
Cdd:pfam12774 161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSNPNLNEDVLLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2102 RALRDFNMPKIVTDDIPVFLGLVGDLFPALDVPRRRKLHFEQMVRQSTLELRLQPEESFILKVVQLEELLAVRHSVFVVG 2181
Cdd:pfam12774 241 RALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLVRHGVMLVG 320
|
....*..
gi 225131082 2182 NAGTGKS 2188
Cdd:pfam12774 321 PTGSGKT 327
|
|
| DHC_N1 |
pfam08385 |
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ... |
240-812 |
0e+00 |
|
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.
Pssm-ID: 462457 Cd Length: 560 Bit Score: 626.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 240 LHAIESVVIEWSHQIQEIIERDSvqrllNGLHLSPQAELDFWMMRRENLSCIYDQLQAPVVLKMVKILTTKQSSYFPTLK 319
Cdd:pfam08385 1 LHALESVVIKWTKQIQDVLKEDS-----QGRNPGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 320 DIFLAVENALLEAQDVELYLRPLRRHIQCLQE-TEFPQTRILIAPLFHTICLIWSHSKFYNTPARVIVLLQEFCNLFINQ 398
Cdd:pfam08385 76 ALDTELTDALNEAKDNVKYLKTLERPFEDLEElTDPPEIIEAIPPLMNTIRLIWSISRYYNTSERMTVLLEKISNQLIEQ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 399 ATAYLSPEDLLRGEIEESLEKVQVAVNILKTFKNSFFNYRKKLASYFMGRklrPWDFQSHLVFCRFDKFLDRLIKIEDIF 478
Cdd:pfam08385 156 CKKYLSPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEESPRER---PWDFSERYIFGRFDAFLERLEKILELF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 479 ATTLEFEKLERLefGGTKGAILNGQVHEMSEELMELCKLFKQSTYDPSDCTNMEFESDYVAFKSKTLEFDRRLGTIICEA 558
Cdd:pfam08385 233 ETIEQFSKLEKI--GGTKGPELEGVIEEILEEFQEAYKVFKSKTYDILDVSNEGFDDDYEEFKERIKDLERRLQAFIDQA 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 559 FFNCNGLEAAFKLLTIFGNFLEKPVVMEIFSLHYSTLVHMFNTELDVCKQLYNEHMKQiecgHVVLNKNMPFTSGNMKWA 638
Cdd:pfam08385 311 FDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQKYN----PSPIAKNMPPVAGAIIWA 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 639 QQVLQRLQMFWSNFASLRYLfLGNPDHALVYQKYVEMTTLLDQFESRIYNEWKSNVDEICEFNLNQPL-VKFSAINGLLC 717
Cdd:pfam08385 387 RQLFRRIQEPMKRFKEELGL-LKHAEGKKVIKKYNELAKKLDEYERLIYEAWLKEVEEASEGNLKRPLlVRHPETGKLLS 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 718 VNFDPKLVAVLREVKYLLMLkKQDIPDSALAIFKKRNTILKYIGNLDLLVQGYNKLKQTLLEVEYPLIEDELRAIDEQLT 797
Cdd:pfam08385 466 VNFDPQLLALLREVKYLQKL-GFEIPESALNIALKEERLRPYAESLELLVRWYNKIRSTLLPVERPLLAPHLKDIDEKLE 544
|
570
....*....|....*.
gi 225131082 798 AATTWLTWQDD-CWGY 812
Cdd:pfam08385 545 PGLTTLTWNSLgIDEY 560
|
|
| MT |
pfam12777 |
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ... |
3104-3448 |
1.07e-169 |
|
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.
Pssm-ID: 463699 [Multi-domain] Cd Length: 344 Bit Score: 526.95 E-value: 1.07e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3104 ERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIGLQTEKVSREKTIADAEERKVTAIQTEVFQKQREC 3183
Cdd:pfam12777 1 ERLENGLLKLHSTAAQVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQKAC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3184 EADLLKAEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLAPRGRVPKDRSWKAAKVFMGKVDDFLQALI 3263
Cdd:pfam12777 81 EEDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILMAPGGKIPKDKSWKAAKIMMAKVDGFLDSLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3264 NYDKEHIPENCLKVVNEhYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCDVEPKRQALAQANLELAAATEKLEA 3343
Cdd:pfam12777 161 KFDKEHIHEACLKAFKP-YLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQALEEANADLAAAQEKLAA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3344 IRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQSIKSFEAQEKTLCGDVLLTAA 3423
Cdd:pfam12777 240 IKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQERTLCGDILLISA 319
|
330 340
....*....|....*....|....*
gi 225131082 3424 FVSYVGPFTRQYRQELVHCKWVPFL 3448
Cdd:pfam12777 320 FISYLGFFTKKYRNELLDKFWIPYI 344
|
|
| DHC_N2 |
pfam08393 |
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ... |
1316-1726 |
3.03e-151 |
|
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.
Pssm-ID: 462462 [Multi-domain] Cd Length: 402 Bit Score: 476.75 E-value: 3.03e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1316 MKQCRKEIKLLKGLWDVIIYVRRSIDNWTKTQWRQIHVEQMDVELRRFAKassitEIWSLNKEVRVWDAYTGLEGTVKDM 1395
Cdd:pfam08393 1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLK-----ELKKLPKELRDWDVAEELKKKIDDF 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1396 TASLRAITELQSPALRDRHWHQLMKAIGVKFL-INEATTLADLLALRLHRVEDDVRRIVDKAVKELGTEKVITEISQTWA 1474
Cdd:pfam08393 76 KKSLPLIEDLRNPALRERHWKQLSEILGFDFDpLSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1475 TMKFSYEVHYRTGIPLLKSDEQLFETLEHNQVQLQTLLQSKYVEYFIEQVLSWQNKLNIADLVIFTWMEVQRTWSHLESI 1554
Cdd:pfam08393 156 TMEFELVPYKDTGTFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1555 FVcSEDIRIQLVKDARRFDGVDAEFKELMFKTAKVENVLEATCRPNLYEKLKDLQSRLSLCEKALAEYLETKRIAFPRFY 1634
Cdd:pfam08393 236 FS-SEDIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFY 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1635 FVSSADLLDILSKGAQPKQVTCHLAKLFDSIADLQFEDNQDVsahraVGMYSKEKEYVPF-QAECECVGHVETWLLQLEQ 1713
Cdd:pfam08393 315 FLSNDELLEILSQTKDPTRVQPHLKKCFEGIASLEFDENKEI-----TGMISKEGEVVPFsKPPVEAKGNVEEWLNELEE 389
|
410
....*....|...
gi 225131082 1714 TMQETVRHSITEA 1726
Cdd:pfam08393 390 EMRETLRDLLKEA 402
|
|
| Dynein_C |
pfam18199 |
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ... |
4226-4508 |
3.87e-112 |
|
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.
Pssm-ID: 465677 Cd Length: 301 Bit Score: 360.01 E-value: 3.87e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 4226 TVTSNTLFRTLLEMQPRNALSGDELGQSTEEKVKNVLDDILEKLPEEFNMAEIMQK--NSNRSPYVLVCFQECERMNILI 4303
Cdd:pfam18199 1 TNETNELLSTLLSLQPRSDSGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKypVGYEDPLNTVLLQEIERFNKLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 4304 REIRISLEQLDLSLKGELALSPAVEAQQFALSYDTVPDTWSKLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWL 4383
Cdd:pfam18199 81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLDDEGPPKVFWL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 4384 SGFFNPQSFLTAIMQTMARKNEWPLDKTRLTADVTKK-TKEDYGHPPREGAYLHGLFMEGARWDTQAGTIVEARLKELAC 4462
Cdd:pfam18199 161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKvSPEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 225131082 4463 PMPVIFAKATPVDRQETKQ-TYECPVYRTKLRG-PSYIWTFRLKSEEK 4508
Cdd:pfam18199 241 PLPVIHLKPVESDKKKLDEnTYECPVYKTSERHsTNFVFSVDLPTDKP 288
|
|
| DYN1 |
COG5245 |
Dynein, heavy chain [Cytoskeleton]; |
1548-4173 |
1.33e-110 |
|
Dynein, heavy chain [Cytoskeleton];
Pssm-ID: 227570 [Multi-domain] Cd Length: 3164 Bit Score: 398.59 E-value: 1.33e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1548 WSHLESIFVCSEDIRIQLVKDARRFDGVDAEFKELMFKTAKVENVLEATCRPNlYEKLKDLQSRLSLCEKALAEYLETKR 1627
Cdd:COG5245 627 RLDEYLMMMSLEDLMPLIPHAVHRKMSLVSGVRGIYKRVVSGCEAINTILEDV-GDDLDLFYKEMDQVFMSIEKVLGLRW 705
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1628 IAFPRFYFVSsaDLLDILSKGAQPKQVTCHLAKLFDSIADLQFednqdvsahravgMYSKEKEYVPFQAECEcvGHVETW 1707
Cdd:COG5245 706 REVERASEVE--ELMDRVRELENRVYSYRFFVKKIAKEEMKTV-------------FSSRIQKKEPFSLDSE--AYVGFF 768
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1708 LLQLEQTMQETVRHSITEAIVAYEEKPRELwiFDFPAQVALTSSQIWwtTDVGIAFSRLEEGYETALKDFHKKQISQLNT 1787
Cdd:COG5245 769 RLYEKSIVIRGINRSMGRVLSQYLESVQEA--LEIEDGSFFVSRHRV--RDGGLEKGRGCDAWENCFDPPLSEYFRILEK 844
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1788 LITLLLGELPPGDRQKIMTICTIDVHARDVVAKLisQKKVVVSPQAFTWLSqLRHRWEDTQKHCFVNICDAQFQYFYEYL 1867
Cdd:COG5245 845 IFPSEEGYFFDEVLKRLDPGHEIKSRIEEIIRMV--TVKYDFCLEVLGSVS-ISELPQGLYKRFIKVRSSYRSAEMFAKN 921
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1868 GNSPRLVITPLTDRCYITLTQSLHLTMSGApagpAGTGKTETTKDLGRALGMMVyvfncsEQMDYKSigNIYKGLVQTGA 1947
Cdd:COG5245 922 TIPFFVFEHSMDTSQHQKLFEAVCDEVCRF----VDTENSRVYGMLVAGKGRIY------DGTEPRS--RIEAGPICEEE 989
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1948 WGcFDEFNRISvEVLSVVAVQVKMIHDAIRNRKKRFVFLGEAITLKPSVGIFITMNPgyagRTELPENLKALFRPCAMVA 2027
Cdd:COG5245 990 RG-TEESALLD-EISRTILVDEYLNSDEFRMLEELNSAVVEHGLKSPSTPVEMIINE----RNIVLEIGRRALDMFLSNI 1063
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2028 P-------DIELICEILLVAEgFVDARALARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVL 2100
Cdd:COG5245 1064 PfgaiksrRESLDREIGAFNN-EVDGIAREEDELMFYPMFKSLKAKHRMLEEKTEYLNKILSITGLPLISDTLRERIDTL 1142
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2101 MRALRDFNMPKIVtddipvflglvgdlFPALDVPRRRKLHFEQMVRQstleLRLQPEESFILKVvqleellavrhsvfvv 2180
Cdd:COG5245 1143 DAEWDSFCRISES--------------LKKYESQQVSGLDVAQFVSF----LRSVDTGAFHAEY---------------- 1188
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2181 GNAGTGKSKILRTL-------NRTYVnmkqkpvwndlnpkavtTDELFgfihHATREWKdgkivysyfiGLFSSILRE-- 2251
Cdd:COG5245 1189 FRVFLCKIKHYTDAcdylwhvKSPYV-----------------KKKYF----DADMELR----------QFFLMFNREdm 1237
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2252 QANLKhDGPKWIVLDGdidpmWIESLNTVMDDNKVLTLASNERialtpfmRLLFEihHLRSaTPATVSRAGILY------ 2325
Cdd:COG5245 1238 EARLA-DSKMEYEVER-----YVEKTKAEVSSLKLELSSVGEG-------QVVVS--NLGS-IGDKVGRCLVEYdsisrl 1301
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2326 ----VNPQDLG-WNPYVASWIDRRRHQSEKANLTILFDkyVPACLDKLRTSFKTITSIPESSLVQTLCVLL--ECLLTP- 2397
Cdd:COG5245 1302 stkgVFLDELGdTKRYLDECLDFFSCFEEVQKEIDELS--MVFCADALRFSADLYHIVKERRFSGVLAGSDasESLGGKs 1379
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2398 ----ENVPSDSPKEVYEVYFVFACIWAFGGtllqDQISDYQADFSRW----WQKEMKAVKFPSQGTIFDYYVDHKTKKLL 2469
Cdd:COG5245 1380 ielaAILEHKDLIVEMKRGINDVLKLRIFG----DKCRESTPRFYLIsdgdLIKDLNERSDYEEMLIMMFNISAVITNNG 1455
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2470 PwadkIAQFTMDPDVPL--QTVLVHTTETARLRYFMELLLEKGKPLMLVGNAGVGKTVFVGDTLASlSEDYIVSRVPFNY 2547
Cdd:COG5245 1456 S----IAGFELRGERVMlrKEVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSLRS-ELITEVKYFNFST 1530
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2548 YTTSTALQKILEKPLEK----KAGHNYGPGGNKKLIYFIDDMNMPEVDLYGTVQPHTLIRQHIDYGHWYDRQKVMLKEIH 2623
Cdd:COG5245 1531 CTMTPSKLSVLERETEYypntGVVRLYPKPVVKDLVLFCDEINLPYGFEYYPPTVIVFLRPLVERQGFWSSIAVSWVTIC 1610
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2624 NCQYVACMNP--MVGSFTISPRLQRHfTVFAF-NFPSLDALNTIYGQIFSFHFQqqaFAPSILRSGPTLIQATIAFHQTM 2700
Cdd:COG5245 1611 GIILYGACNPgtDEGRVKYYERFIRK-PVFVFcCYPELASLRNIYEAVLMGSYL---CFDEFNRLSEETMSASVELYLSS 1686
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2701 MCNFlPTAIKFHYIFNLRDLSNVFQGILFASPECLKGP-LDLIHLWLHESARVYGDKLIDKKDCDLFQRRMLETAYKYFE 2779
Cdd:COG5245 1687 KDKT-KFFLQMNYGYKPRELTRSLRAIFGYAETRIDTPdVSLIIDWYCEAIREKIDRLVQQKESSTSRQDLYDFGLRAIR 1765
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2780 GID-SH---------MLLQQPLIYCHFADrgkdphyMPVKDWEVLKTILTETLDNynelnaamHLVLFEDAMQHVCRISR 2849
Cdd:COG5245 1766 EMIaGHigeaeitfsMILFFGMACLLKKD-------LAVFVEEVRKIFGSSHLDV--------EAVAYKDALLHILRSRR 1830
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2850 ILRTPQGCALLVGVGGSGKQSLSRLAAYLRGLEVFQITLTEGYGIQELRVDLANLYIRTGAKNMPTVFLLTDAQVLDESF 2929
Cdd:COG5245 1831 GLLVVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVESSF 1910
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2930 LVLINDLLASGEIPDLFSDEDVDKIISGIHNEVHALGM-VDSRENCWKFFMARVRLQLKIILCFSPVGRTLRVRARKFPA 3008
Cdd:COG5245 1911 LEDFNPLLDNNRFLCLFSGNERIRIPENLRFVFESTSLeKDTEATLTRVFLVYMEENLPVVFSACCSQDTSVLAGIRSPA 1990
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3009 IVNCTAIDWFHAWPQEALVSVSRRFIEETKGIEPVHKDS--------ISLFMAHVHTTVNEMSTRYYQNERR-HNYTTPK 3079
Cdd:COG5245 1991 LKNRCFIDFKKLWDTEEMSQYANSVETLSRDGGRVFFINgelgvgkgALISEVFGDDAVVIEGRGFEISMIEgSLGESKI 2070
|
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3080 SFLEQISLFKNLLKKKQNEVSEKKERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIgLQTEKVSREK 3159
Cdd:COG5245 2071 KFIGGLKVYDARCVIYIEELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGT-PGERLEREVK 2149
|
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3160 TIADAEERKVTAIQTEVFQKQRECEADLLK-AEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLaprGR 3238
Cdd:COG5245 2150 SVFVEAPRDMLFLLEEEVRKRKGSVMKFKSsKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLL---GF 2226
|
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3239 VPKDrsWKAAKVFMgKVDDFLQALINYDKE-HIPENCLKVVNEHYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVY 3317
Cdd:COG5245 2227 EAKI--WFGEQQSL-RRDDFIRIIGKYPDEiEFDLEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVL 2303
|
1850 1860 1870 1880 1890 1900 1910 1920
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3318 CDVEPKRQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKK 3397
Cdd:COG5245 2304 EVKIPLREEEKRIDGEAFLVEDRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVSEILINED 2383
|
1930 1940 1950 1960 1970 1980 1990 2000
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3398 IRWGQSIKSFEAQEKTLCGDVLLTAAFVSYVGPFTRQYRQ-ELVHCKwvPFLQQKVSIP-------LTEGLDLISmltDD 3469
Cdd:COG5245 2384 SEWGGVFSEVPKLMVELDGDGHPSSCLHPYIGTLGFLCRAiEFGMSF--IRISKEFRDKeirrrqfITEGVQKIE---DF 2458
|
2010 2020 2030 2040 2050 2060 2070 2080
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3470 ATIAAWNNEGLPSDRMSTENAAILthcerwPLVIDPQQQGIKWIKNKYgmDLKVTHLG---QKGFLNAIETALAFGDVIL 3546
Cdd:COG5245 2459 KEEACSTDYGLENSRIRKDLQDLT------AVLNDPSSKIVTSQRQMY--DEKKAILGsfrEMEFAFGLSQARREGSDKI 2530
|
2090 2100 2110 2120 2130 2140 2150 2160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3547 IENlEETIDPVLDPLLGRNTIKKGKYIR--IGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLL 3624
Cdd:COG5245 2531 IGD-AEALDEEIGRLIKEEFKSNLSEVKvmINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEIP 2609
|
2170 2180 2190 2200 2210 2220 2230 2240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3625 AEVVSIERPDLEKLKLVLTKHQNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEIEHKVIEAKENERK 3704
Cdd:COG5245 2610 DALEKLVSGPLFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIEDR 2689
|
2250 2260 2270 2280 2290 2300 2310 2320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3705 INEARECYRPLAARASLLYFVINDLQKINPLYQFSLKAFNVLFHRaieqadkVEDMQGRISILMESITHAVFLYtsqaLF 3784
Cdd:COG5245 2690 IDALKSEYNASVKRLESIRVEIAMFDEKALMYNKSICELSSEFEK-------WRRMKSKYLCAIRYMLMSSEWI----LD 2758
|
2330 2340 2350 2360 2370 2380 2390 2400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3785 EKDKLTFLSQMAFQILLRKKEIdpleLDFLLRFTVEHTHLSpvdfltSQSWSAIKAIAvmEEFRGIDRDVEGSAKQWRkW 3864
Cdd:COG5245 2759 HEDRSGFIHRLDVSFLLRTKRF----VSTLLEDKNYRQVLS------SCSLYGNDVIS--HSCDRFDRDVYRALKHQM-D 2825
|
2410 2420 2430 2440 2450 2460 2470 2480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3865 VESECPEKEKLPQ-EWKKKSLIQKLILLRamrpdrmtyalrnFVEEKLGAKYvertrlDLVKAFEESSPAT-PIFFILSP 3942
Cdd:COG5245 2826 NRTHSTILTSNSKtNPYKEYTYNDSWAEA-------------FEVEDSGDLY------KFEEGLLELIVGHaPLIYAHKK 2886
|
2490 2500 2510 2520 2530 2540 2550 2560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3943 GVDALKDLEILGKRlgftidsgkfhnvslgqGQETVAEVALEKASKGGHWVILQNVHLVAKWLGTLEKLLERFSQGSHRD 4022
Cdd:COG5245 2887 SLENERNVDRLGSK-----------------ENEVYAVLNSLFSRKEKSWFEVYNISLSFGWFKRYVEDVVYPIKASRVC 2949
|
2570 2580 2590 2600 2610 2620 2630 2640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 4023 YRVFMSAESAPTPDEHIIPQGLLENSIKITNEPPTG-MLANLHAALYnFDQDTLEICSKEqefksILFSLCYFHACVAGR 4101
Cdd:COG5245 2950 GKVKNMWTSMVDADMLPIQLLIAIDSFVSSTYPETGcGYADLVEIDR-YPFDYTLVIACD-----DAFYLSWEHAAVASV 3023
|
2650 2660 2670 2680 2690 2700 2710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225131082 4102 LRFGPQGWSRSYPFNPGDLTICASVLYNYLEANS--KVPWEDLRYLFGEIMYGGHITDDWD----RKLCRVYLEEFVN 4173
Cdd:COG5245 3024 ISAGPKENNEEIYFGDKDFEFKTHLLKNILFLNHlnARKWGNNRDLIFTIVYGKKHSLMEDskvvDKYCRGYGAHETS 3101
|
|
| AAA_9 |
pfam12781 |
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ... |
3473-3691 |
2.77e-108 |
|
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.
Pssm-ID: 463702 [Multi-domain] Cd Length: 222 Bit Score: 345.20 E-value: 2.77e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3473 AAWNNEGLPSDRMSTENAAILTHCERWPLVIDPQQQGIKWIKNKYGM-DLKVTHLGQKGFLNAIETALAFGDVILIENLE 3551
Cdd:pfam12781 1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDnGLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3552 ETIDPVLDPLLGRNTIKKG--KYIRIGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLLAEVVS 3629
Cdd:pfam12781 81 EELDPILDPVLLKEIFKGGgrKVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225131082 3630 IERPDLEKLKLVLTKHQNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEI 3691
Cdd:pfam12781 161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
3319-3414 |
1.46e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 44.51 E-value: 1.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3319 DVEPKRQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKI 3398
Cdd:COG4372 60 ELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIA 139
|
90
....*....|....*.
gi 225131082 3399 RWGQSIKSFEAQEKTL 3414
Cdd:COG4372 140 ELQSEIAEREEELKEL 155
|
|
| Surf_Exclu_PgrA |
TIGR04320 |
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ... |
3111-3205 |
7.17e-03 |
|
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.
Pssm-ID: 275124 [Multi-domain] Cd Length: 356 Bit Score: 42.02 E-value: 7.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3111 QKLKTTASQVGDLKARLASQEAEL-QLRNHDAEALITKIGLQTEKVSREKTIADAEER--KVTAIQTEVFQKQ-RECEAD 3186
Cdd:TIGR04320 247 TPIPNPPNSLAALQAKLATAQADLaAAQTALNTAQAALTSAQTAYAAAQAALATAQKElaNAQAQALQTAQNNlATAQAA 326
|
90
....*....|....*....
gi 225131082 3187 LLKAEPALVAATAALNTLN 3205
Cdd:TIGR04320 327 LANAEARLAKAKEALANLN 345
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| AAA_6 |
pfam12774 |
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ... |
1862-2188 |
0e+00 |
|
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.
Pssm-ID: 463697 [Multi-domain] Cd Length: 327 Bit Score: 627.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1862 YFYEYLGNSPRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGTGKTETTKDLGRALGMMVYVFNCSEQMDYKSIGNIYKG 1941
Cdd:pfam12774 1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1942 LVQTGAWGCFDEFNRISVEVLSVVAVQVKMIHDAIRNRKKRFVFLGEAITLKPSVGIFITMNPGYAGRTELPENLKALFR 2021
Cdd:pfam12774 81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2022 PCAMVAPDIELICEILLVAEGFVDARALARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVLM 2101
Cdd:pfam12774 161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSNPNLNEDVLLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2102 RALRDFNMPKIVTDDIPVFLGLVGDLFPALDVPRRRKLHFEQMVRQSTLELRLQPEESFILKVVQLEELLAVRHSVFVVG 2181
Cdd:pfam12774 241 RALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLVRHGVMLVG 320
|
....*..
gi 225131082 2182 NAGTGKS 2188
Cdd:pfam12774 321 PTGSGKT 327
|
|
| DHC_N1 |
pfam08385 |
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ... |
240-812 |
0e+00 |
|
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.
Pssm-ID: 462457 Cd Length: 560 Bit Score: 626.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 240 LHAIESVVIEWSHQIQEIIERDSvqrllNGLHLSPQAELDFWMMRRENLSCIYDQLQAPVVLKMVKILTTKQSSYFPTLK 319
Cdd:pfam08385 1 LHALESVVIKWTKQIQDVLKEDS-----QGRNPGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 320 DIFLAVENALLEAQDVELYLRPLRRHIQCLQE-TEFPQTRILIAPLFHTICLIWSHSKFYNTPARVIVLLQEFCNLFINQ 398
Cdd:pfam08385 76 ALDTELTDALNEAKDNVKYLKTLERPFEDLEElTDPPEIIEAIPPLMNTIRLIWSISRYYNTSERMTVLLEKISNQLIEQ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 399 ATAYLSPEDLLRGEIEESLEKVQVAVNILKTFKNSFFNYRKKLASYFMGRklrPWDFQSHLVFCRFDKFLDRLIKIEDIF 478
Cdd:pfam08385 156 CKKYLSPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEESPRER---PWDFSERYIFGRFDAFLERLEKILELF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 479 ATTLEFEKLERLefGGTKGAILNGQVHEMSEELMELCKLFKQSTYDPSDCTNMEFESDYVAFKSKTLEFDRRLGTIICEA 558
Cdd:pfam08385 233 ETIEQFSKLEKI--GGTKGPELEGVIEEILEEFQEAYKVFKSKTYDILDVSNEGFDDDYEEFKERIKDLERRLQAFIDQA 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 559 FFNCNGLEAAFKLLTIFGNFLEKPVVMEIFSLHYSTLVHMFNTELDVCKQLYNEHMKQiecgHVVLNKNMPFTSGNMKWA 638
Cdd:pfam08385 311 FDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQKYN----PSPIAKNMPPVAGAIIWA 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 639 QQVLQRLQMFWSNFASLRYLfLGNPDHALVYQKYVEMTTLLDQFESRIYNEWKSNVDEICEFNLNQPL-VKFSAINGLLC 717
Cdd:pfam08385 387 RQLFRRIQEPMKRFKEELGL-LKHAEGKKVIKKYNELAKKLDEYERLIYEAWLKEVEEASEGNLKRPLlVRHPETGKLLS 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 718 VNFDPKLVAVLREVKYLLMLkKQDIPDSALAIFKKRNTILKYIGNLDLLVQGYNKLKQTLLEVEYPLIEDELRAIDEQLT 797
Cdd:pfam08385 466 VNFDPQLLALLREVKYLQKL-GFEIPESALNIALKEERLRPYAESLELLVRWYNKIRSTLLPVERPLLAPHLKDIDEKLE 544
|
570
....*....|....*.
gi 225131082 798 AATTWLTWQDD-CWGY 812
Cdd:pfam08385 545 PGLTTLTWNSLgIDEY 560
|
|
| MT |
pfam12777 |
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ... |
3104-3448 |
1.07e-169 |
|
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.
Pssm-ID: 463699 [Multi-domain] Cd Length: 344 Bit Score: 526.95 E-value: 1.07e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3104 ERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIGLQTEKVSREKTIADAEERKVTAIQTEVFQKQREC 3183
Cdd:pfam12777 1 ERLENGLLKLHSTAAQVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQKAC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3184 EADLLKAEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLAPRGRVPKDRSWKAAKVFMGKVDDFLQALI 3263
Cdd:pfam12777 81 EEDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILMAPGGKIPKDKSWKAAKIMMAKVDGFLDSLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3264 NYDKEHIPENCLKVVNEhYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVYCDVEPKRQALAQANLELAAATEKLEA 3343
Cdd:pfam12777 161 KFDKEHIHEACLKAFKP-YLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQALEEANADLAAAQEKLAA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3344 IRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQSIKSFEAQEKTLCGDVLLTAA 3423
Cdd:pfam12777 240 IKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQERTLCGDILLISA 319
|
330 340
....*....|....*....|....*
gi 225131082 3424 FVSYVGPFTRQYRQELVHCKWVPFL 3448
Cdd:pfam12777 320 FISYLGFFTKKYRNELLDKFWIPYI 344
|
|
| DHC_N2 |
pfam08393 |
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ... |
1316-1726 |
3.03e-151 |
|
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.
Pssm-ID: 462462 [Multi-domain] Cd Length: 402 Bit Score: 476.75 E-value: 3.03e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1316 MKQCRKEIKLLKGLWDVIIYVRRSIDNWTKTQWRQIHVEQMDVELRRFAKassitEIWSLNKEVRVWDAYTGLEGTVKDM 1395
Cdd:pfam08393 1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLK-----ELKKLPKELRDWDVAEELKKKIDDF 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1396 TASLRAITELQSPALRDRHWHQLMKAIGVKFL-INEATTLADLLALRLHRVEDDVRRIVDKAVKELGTEKVITEISQTWA 1474
Cdd:pfam08393 76 KKSLPLIEDLRNPALRERHWKQLSEILGFDFDpLSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1475 TMKFSYEVHYRTGIPLLKSDEQLFETLEHNQVQLQTLLQSKYVEYFIEQVLSWQNKLNIADLVIFTWMEVQRTWSHLESI 1554
Cdd:pfam08393 156 TMEFELVPYKDTGTFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1555 FVcSEDIRIQLVKDARRFDGVDAEFKELMFKTAKVENVLEATCRPNLYEKLKDLQSRLSLCEKALAEYLETKRIAFPRFY 1634
Cdd:pfam08393 236 FS-SEDIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFY 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1635 FVSSADLLDILSKGAQPKQVTCHLAKLFDSIADLQFEDNQDVsahraVGMYSKEKEYVPF-QAECECVGHVETWLLQLEQ 1713
Cdd:pfam08393 315 FLSNDELLEILSQTKDPTRVQPHLKKCFEGIASLEFDENKEI-----TGMISKEGEVVPFsKPPVEAKGNVEEWLNELEE 389
|
410
....*....|...
gi 225131082 1714 TMQETVRHSITEA 1726
Cdd:pfam08393 390 EMRETLRDLLKEA 402
|
|
| Dynein_C |
pfam18199 |
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ... |
4226-4508 |
3.87e-112 |
|
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.
Pssm-ID: 465677 Cd Length: 301 Bit Score: 360.01 E-value: 3.87e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 4226 TVTSNTLFRTLLEMQPRNALSGDELGQSTEEKVKNVLDDILEKLPEEFNMAEIMQK--NSNRSPYVLVCFQECERMNILI 4303
Cdd:pfam18199 1 TNETNELLSTLLSLQPRSDSGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKypVGYEDPLNTVLLQEIERFNKLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 4304 REIRISLEQLDLSLKGELALSPAVEAQQFALSYDTVPDTWSKLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWL 4383
Cdd:pfam18199 81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLDDEGPPKVFWL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 4384 SGFFNPQSFLTAIMQTMARKNEWPLDKTRLTADVTKK-TKEDYGHPPREGAYLHGLFMEGARWDTQAGTIVEARLKELAC 4462
Cdd:pfam18199 161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKvSPEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 225131082 4463 PMPVIFAKATPVDRQETKQ-TYECPVYRTKLRG-PSYIWTFRLKSEEK 4508
Cdd:pfam18199 241 PLPVIHLKPVESDKKKLDEnTYECPVYKTSERHsTNFVFSVDLPTDKP 288
|
|
| DYN1 |
COG5245 |
Dynein, heavy chain [Cytoskeleton]; |
1548-4173 |
1.33e-110 |
|
Dynein, heavy chain [Cytoskeleton];
Pssm-ID: 227570 [Multi-domain] Cd Length: 3164 Bit Score: 398.59 E-value: 1.33e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1548 WSHLESIFVCSEDIRIQLVKDARRFDGVDAEFKELMFKTAKVENVLEATCRPNlYEKLKDLQSRLSLCEKALAEYLETKR 1627
Cdd:COG5245 627 RLDEYLMMMSLEDLMPLIPHAVHRKMSLVSGVRGIYKRVVSGCEAINTILEDV-GDDLDLFYKEMDQVFMSIEKVLGLRW 705
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1628 IAFPRFYFVSsaDLLDILSKGAQPKQVTCHLAKLFDSIADLQFednqdvsahravgMYSKEKEYVPFQAECEcvGHVETW 1707
Cdd:COG5245 706 REVERASEVE--ELMDRVRELENRVYSYRFFVKKIAKEEMKTV-------------FSSRIQKKEPFSLDSE--AYVGFF 768
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1708 LLQLEQTMQETVRHSITEAIVAYEEKPRELwiFDFPAQVALTSSQIWwtTDVGIAFSRLEEGYETALKDFHKKQISQLNT 1787
Cdd:COG5245 769 RLYEKSIVIRGINRSMGRVLSQYLESVQEA--LEIEDGSFFVSRHRV--RDGGLEKGRGCDAWENCFDPPLSEYFRILEK 844
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1788 LITLLLGELPPGDRQKIMTICTIDVHARDVVAKLisQKKVVVSPQAFTWLSqLRHRWEDTQKHCFVNICDAQFQYFYEYL 1867
Cdd:COG5245 845 IFPSEEGYFFDEVLKRLDPGHEIKSRIEEIIRMV--TVKYDFCLEVLGSVS-ISELPQGLYKRFIKVRSSYRSAEMFAKN 921
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1868 GNSPRLVITPLTDRCYITLTQSLHLTMSGApagpAGTGKTETTKDLGRALGMMVyvfncsEQMDYKSigNIYKGLVQTGA 1947
Cdd:COG5245 922 TIPFFVFEHSMDTSQHQKLFEAVCDEVCRF----VDTENSRVYGMLVAGKGRIY------DGTEPRS--RIEAGPICEEE 989
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1948 WGcFDEFNRISvEVLSVVAVQVKMIHDAIRNRKKRFVFLGEAITLKPSVGIFITMNPgyagRTELPENLKALFRPCAMVA 2027
Cdd:COG5245 990 RG-TEESALLD-EISRTILVDEYLNSDEFRMLEELNSAVVEHGLKSPSTPVEMIINE----RNIVLEIGRRALDMFLSNI 1063
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2028 P-------DIELICEILLVAEgFVDARALARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVL 2100
Cdd:COG5245 1064 PfgaiksrRESLDREIGAFNN-EVDGIAREEDELMFYPMFKSLKAKHRMLEEKTEYLNKILSITGLPLISDTLRERIDTL 1142
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2101 MRALRDFNMPKIVtddipvflglvgdlFPALDVPRRRKLHFEQMVRQstleLRLQPEESFILKVvqleellavrhsvfvv 2180
Cdd:COG5245 1143 DAEWDSFCRISES--------------LKKYESQQVSGLDVAQFVSF----LRSVDTGAFHAEY---------------- 1188
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2181 GNAGTGKSKILRTL-------NRTYVnmkqkpvwndlnpkavtTDELFgfihHATREWKdgkivysyfiGLFSSILRE-- 2251
Cdd:COG5245 1189 FRVFLCKIKHYTDAcdylwhvKSPYV-----------------KKKYF----DADMELR----------QFFLMFNREdm 1237
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2252 QANLKhDGPKWIVLDGdidpmWIESLNTVMDDNKVLTLASNERialtpfmRLLFEihHLRSaTPATVSRAGILY------ 2325
Cdd:COG5245 1238 EARLA-DSKMEYEVER-----YVEKTKAEVSSLKLELSSVGEG-------QVVVS--NLGS-IGDKVGRCLVEYdsisrl 1301
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2326 ----VNPQDLG-WNPYVASWIDRRRHQSEKANLTILFDkyVPACLDKLRTSFKTITSIPESSLVQTLCVLL--ECLLTP- 2397
Cdd:COG5245 1302 stkgVFLDELGdTKRYLDECLDFFSCFEEVQKEIDELS--MVFCADALRFSADLYHIVKERRFSGVLAGSDasESLGGKs 1379
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2398 ----ENVPSDSPKEVYEVYFVFACIWAFGGtllqDQISDYQADFSRW----WQKEMKAVKFPSQGTIFDYYVDHKTKKLL 2469
Cdd:COG5245 1380 ielaAILEHKDLIVEMKRGINDVLKLRIFG----DKCRESTPRFYLIsdgdLIKDLNERSDYEEMLIMMFNISAVITNNG 1455
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2470 PwadkIAQFTMDPDVPL--QTVLVHTTETARLRYFMELLLEKGKPLMLVGNAGVGKTVFVGDTLASlSEDYIVSRVPFNY 2547
Cdd:COG5245 1456 S----IAGFELRGERVMlrKEVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSLRS-ELITEVKYFNFST 1530
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2548 YTTSTALQKILEKPLEK----KAGHNYGPGGNKKLIYFIDDMNMPEVDLYGTVQPHTLIRQHIDYGHWYDRQKVMLKEIH 2623
Cdd:COG5245 1531 CTMTPSKLSVLERETEYypntGVVRLYPKPVVKDLVLFCDEINLPYGFEYYPPTVIVFLRPLVERQGFWSSIAVSWVTIC 1610
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2624 NCQYVACMNP--MVGSFTISPRLQRHfTVFAF-NFPSLDALNTIYGQIFSFHFQqqaFAPSILRSGPTLIQATIAFHQTM 2700
Cdd:COG5245 1611 GIILYGACNPgtDEGRVKYYERFIRK-PVFVFcCYPELASLRNIYEAVLMGSYL---CFDEFNRLSEETMSASVELYLSS 1686
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2701 MCNFlPTAIKFHYIFNLRDLSNVFQGILFASPECLKGP-LDLIHLWLHESARVYGDKLIDKKDCDLFQRRMLETAYKYFE 2779
Cdd:COG5245 1687 KDKT-KFFLQMNYGYKPRELTRSLRAIFGYAETRIDTPdVSLIIDWYCEAIREKIDRLVQQKESSTSRQDLYDFGLRAIR 1765
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2780 GID-SH---------MLLQQPLIYCHFADrgkdphyMPVKDWEVLKTILTETLDNynelnaamHLVLFEDAMQHVCRISR 2849
Cdd:COG5245 1766 EMIaGHigeaeitfsMILFFGMACLLKKD-------LAVFVEEVRKIFGSSHLDV--------EAVAYKDALLHILRSRR 1830
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2850 ILRTPQGCALLVGVGGSGKQSLSRLAAYLRGLEVFQITLTEGYGIQELRVDLANLYIRTGAKNMPTVFLLTDAQVLDESF 2929
Cdd:COG5245 1831 GLLVVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVESSF 1910
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2930 LVLINDLLASGEIPDLFSDEDVDKIISGIHNEVHALGM-VDSRENCWKFFMARVRLQLKIILCFSPVGRTLRVRARKFPA 3008
Cdd:COG5245 1911 LEDFNPLLDNNRFLCLFSGNERIRIPENLRFVFESTSLeKDTEATLTRVFLVYMEENLPVVFSACCSQDTSVLAGIRSPA 1990
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3009 IVNCTAIDWFHAWPQEALVSVSRRFIEETKGIEPVHKDS--------ISLFMAHVHTTVNEMSTRYYQNERR-HNYTTPK 3079
Cdd:COG5245 1991 LKNRCFIDFKKLWDTEEMSQYANSVETLSRDGGRVFFINgelgvgkgALISEVFGDDAVVIEGRGFEISMIEgSLGESKI 2070
|
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3080 SFLEQISLFKNLLKKKQNEVSEKKERLVNGIQKLKTTASQVGDLKARLASQEAELQLRNHDAEALITKIgLQTEKVSREK 3159
Cdd:COG5245 2071 KFIGGLKVYDARCVIYIEELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGT-PGERLEREVK 2149
|
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3160 TIADAEERKVTAIQTEVFQKQRECEADLLK-AEPALVAATAALNTLNRVNLSELKAFPNPPIAVTNVTAAVMVLLaprGR 3238
Cdd:COG5245 2150 SVFVEAPRDMLFLLEEEVRKRKGSVMKFKSsKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLL---GF 2226
|
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3239 VPKDrsWKAAKVFMgKVDDFLQALINYDKE-HIPENCLKVVNEHYLKDPEFNPNLIRTKSFAAAGLCAWVINIIKFYEVY 3317
Cdd:COG5245 2227 EAKI--WFGEQQSL-RRDDFIRIIGKYPDEiEFDLEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVL 2303
|
1850 1860 1870 1880 1890 1900 1910 1920
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3318 CDVEPKRQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKK 3397
Cdd:COG5245 2304 EVKIPLREEEKRIDGEAFLVEDRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVSEILINED 2383
|
1930 1940 1950 1960 1970 1980 1990 2000
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3398 IRWGQSIKSFEAQEKTLCGDVLLTAAFVSYVGPFTRQYRQ-ELVHCKwvPFLQQKVSIP-------LTEGLDLISmltDD 3469
Cdd:COG5245 2384 SEWGGVFSEVPKLMVELDGDGHPSSCLHPYIGTLGFLCRAiEFGMSF--IRISKEFRDKeirrrqfITEGVQKIE---DF 2458
|
2010 2020 2030 2040 2050 2060 2070 2080
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3470 ATIAAWNNEGLPSDRMSTENAAILthcerwPLVIDPQQQGIKWIKNKYgmDLKVTHLG---QKGFLNAIETALAFGDVIL 3546
Cdd:COG5245 2459 KEEACSTDYGLENSRIRKDLQDLT------AVLNDPSSKIVTSQRQMY--DEKKAILGsfrEMEFAFGLSQARREGSDKI 2530
|
2090 2100 2110 2120 2130 2140 2150 2160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3547 IENlEETIDPVLDPLLGRNTIKKGKYIR--IGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLL 3624
Cdd:COG5245 2531 IGD-AEALDEEIGRLIKEEFKSNLSEVKvmINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEIP 2609
|
2170 2180 2190 2200 2210 2220 2230 2240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3625 AEVVSIERPDLEKLKLVLTKHQNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEIEHKVIEAKENERK 3704
Cdd:COG5245 2610 DALEKLVSGPLFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIEDR 2689
|
2250 2260 2270 2280 2290 2300 2310 2320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3705 INEARECYRPLAARASLLYFVINDLQKINPLYQFSLKAFNVLFHRaieqadkVEDMQGRISILMESITHAVFLYtsqaLF 3784
Cdd:COG5245 2690 IDALKSEYNASVKRLESIRVEIAMFDEKALMYNKSICELSSEFEK-------WRRMKSKYLCAIRYMLMSSEWI----LD 2758
|
2330 2340 2350 2360 2370 2380 2390 2400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3785 EKDKLTFLSQMAFQILLRKKEIdpleLDFLLRFTVEHTHLSpvdfltSQSWSAIKAIAvmEEFRGIDRDVEGSAKQWRkW 3864
Cdd:COG5245 2759 HEDRSGFIHRLDVSFLLRTKRF----VSTLLEDKNYRQVLS------SCSLYGNDVIS--HSCDRFDRDVYRALKHQM-D 2825
|
2410 2420 2430 2440 2450 2460 2470 2480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3865 VESECPEKEKLPQ-EWKKKSLIQKLILLRamrpdrmtyalrnFVEEKLGAKYvertrlDLVKAFEESSPAT-PIFFILSP 3942
Cdd:COG5245 2826 NRTHSTILTSNSKtNPYKEYTYNDSWAEA-------------FEVEDSGDLY------KFEEGLLELIVGHaPLIYAHKK 2886
|
2490 2500 2510 2520 2530 2540 2550 2560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3943 GVDALKDLEILGKRlgftidsgkfhnvslgqGQETVAEVALEKASKGGHWVILQNVHLVAKWLGTLEKLLERFSQGSHRD 4022
Cdd:COG5245 2887 SLENERNVDRLGSK-----------------ENEVYAVLNSLFSRKEKSWFEVYNISLSFGWFKRYVEDVVYPIKASRVC 2949
|
2570 2580 2590 2600 2610 2620 2630 2640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 4023 YRVFMSAESAPTPDEHIIPQGLLENSIKITNEPPTG-MLANLHAALYnFDQDTLEICSKEqefksILFSLCYFHACVAGR 4101
Cdd:COG5245 2950 GKVKNMWTSMVDADMLPIQLLIAIDSFVSSTYPETGcGYADLVEIDR-YPFDYTLVIACD-----DAFYLSWEHAAVASV 3023
|
2650 2660 2670 2680 2690 2700 2710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225131082 4102 LRFGPQGWSRSYPFNPGDLTICASVLYNYLEANS--KVPWEDLRYLFGEIMYGGHITDDWD----RKLCRVYLEEFVN 4173
Cdd:COG5245 3024 ISAGPKENNEEIYFGDKDFEFKTHLLKNILFLNHlnARKWGNNRDLIFTIVYGKKHSLMEDskvvDKYCRGYGAHETS 3101
|
|
| AAA_9 |
pfam12781 |
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ... |
3473-3691 |
2.77e-108 |
|
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.
Pssm-ID: 463702 [Multi-domain] Cd Length: 222 Bit Score: 345.20 E-value: 2.77e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3473 AAWNNEGLPSDRMSTENAAILTHCERWPLVIDPQQQGIKWIKNKYGM-DLKVTHLGQKGFLNAIETALAFGDVILIENLE 3551
Cdd:pfam12781 1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDnGLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3552 ETIDPVLDPLLGRNTIKKG--KYIRIGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEAQLLAEVVS 3629
Cdd:pfam12781 81 EELDPILDPVLLKEIFKGGgrKVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225131082 3630 IERPDLEKLKLVLTKHQNDFKIELKYLEDDLLLRLSAAEGSFLDDTKLVERLEATKTTVAEI 3691
Cdd:pfam12781 161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
|
|
| AAA_8 |
pfam12780 |
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ... |
2832-3091 |
1.41e-105 |
|
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.
Pssm-ID: 463701 [Multi-domain] Cd Length: 259 Bit Score: 339.20 E-value: 1.41e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2832 MHLVLFEDAMQHVCRISRILRTPQGCALLVGVGGSGKQSLSRLAAYLRGLEVFQITLTEGYGIQELRVDLANLYIRTGAK 2911
Cdd:pfam12780 1 MDLVLFRDALEHLCRICRILRQPRGHALLVGVGGSGRQSLTKLAAFIAGYELFQIEVTRNYDMNEFREDLKKVLKKAGIK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2912 NMPTVFLLTDAQVLDESFLVLINDLLASGEIPDLFSDEDVDKIISGIHNEVHALGMVDSRENCWKFFMARVRLQLKIILC 2991
Cdd:pfam12780 81 GKPTVFLLSDTQIIEESFLEDINNLLNSGEVPNLFTDEEKEEIIESVRDDAKAQNIEDSREAVYNYFVKRCRNNLHIVLC 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2992 FSPVGRTLRVRARKFPAIVNCTAIDWFHAWPQEALVSVSRRFIEETKGIEpVHKDSISLFMAHVHTTVNEMSTRYYQNER 3071
Cdd:pfam12780 161 MSPVGEAFRNRLRMFPSLVNCCTIDWFNEWPEEALLAVAEKFLEDIEIPE-ELKSNVVKVFVYVHSSVEDMSKKFYEELK 239
|
250 260
....*....|....*....|
gi 225131082 3072 RHNYTTPKSFLEQISLFKNL 3091
Cdd:pfam12780 240 RKNYVTPKSYLELLRLYKNL 259
|
|
| AAA_7 |
pfam12775 |
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 ... |
2481-2656 |
8.86e-90 |
|
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the third nucleotide binding sites in the dynein motor. However, AAA3 has lost the catalytic residues necessary for ATP hydrolysis (the Walker B glutamate, the arginine finger, sensor-I and sensor-II motifs).
Pssm-ID: 463698 [Multi-domain] Cd Length: 179 Bit Score: 290.45 E-value: 8.86e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2481 DPDVPLQTVLVHTTETARLRYFMELLLEKGKPLMLVGNAGVGKTVFVGDTLASLS-EDYIVSRVPFNYYTTSTALQKILE 2559
Cdd:pfam12775 2 PPDVPFSEILVPTVDTVRYTYLLDLLLKNGKPVLLVGPTGTGKTVIIQNLLRKLDkEKYLPLFINFSAQTTSNQTQDIIE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2560 KPLEKKAGHNYGPGGNKKLIYFIDDMNMPEVDLYGTVQPHTLIRQHIDYGHWYDRQKVMLKEIHNCQYVACMNPMVGS-F 2638
Cdd:pfam12775 82 SKLEKRRKGVYGPPGGKKLVVFIDDLNMPAVDTYGAQPPIELLRQWLDYGGWYDRKKLTFKEIVDVQFVAAMGPPGGGrN 161
|
170
....*....|....*...
gi 225131082 2639 TISPRLQRHFTVFAFNFP 2656
Cdd:pfam12775 162 DITPRLLRHFNVFNITFP 179
|
|
| AAA_lid_11 |
pfam18198 |
Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the ... |
4084-4220 |
3.86e-65 |
|
Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the C-terminal region of dynein heavy chain.
Pssm-ID: 465676 Cd Length: 139 Bit Score: 218.09 E-value: 3.86e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 4084 FKSILFSLCYFHACVAGRLRFGPQGWSRSYPFNPGDLTICASVLYNYLEANS-KVPWEDLRYLFGEIMYGGHITDDWDRK 4162
Cdd:pfam18198 1 WKKLLFGLCFFHAVVQERRKFGPLGWNIPYEFNESDLRISVQQLQMYLDEYDeKIPWDALRYLIGEINYGGRVTDDWDRR 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 225131082 4163 LCRVYLEEFVNPSLTEDELMLAPG-FAAPPYLDYAGYHQYIEEMLPPESPALYGLHPNA 4220
Cdd:pfam18198 81 LLNTYLEEFFNPEVLEEDFKFSPSlYYIPPDGDLEDYLEYIESLPLVDSPEVFGLHPNA 139
|
|
| Dynein_heavy |
pfam03028 |
Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of ... |
3931-4052 |
3.03e-49 |
|
Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.
Pssm-ID: 460782 Cd Length: 115 Bit Score: 171.86 E-value: 3.03e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3931 SPATPIFFILSPGVDALKDLEILGKRLGFTidsGKFHNVSLGQGQETVAEVALEKASKGGHWVILQNVHLVAKWLGTLEK 4010
Cdd:pfam03028 1 SPTTPLIFILSPGSDPTADLEKLAKKLGFG---GKLHSISLGQGQGPIAEKLIEEAAKEGGWVLLQNCHLALSWMPELEK 77
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 225131082 4011 LLERF-SQGSHRDYRVFMSAEsaPTPDehiIPQGLLENSIKIT 4052
Cdd:pfam03028 78 ILEELpEETLHPDFRLWLTSE--PSPK---FPISILQNSIKIT 115
|
|
| AAA_lid_1 |
pfam17857 |
AAA+ lid domain; This domain represents the AAA lid domain from dynein heavy chain D3. |
2689-2786 |
2.28e-37 |
|
AAA+ lid domain; This domain represents the AAA lid domain from dynein heavy chain D3.
Pssm-ID: 465535 [Multi-domain] Cd Length: 100 Bit Score: 137.37 E-value: 2.28e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2689 LIQATIAFHQTMMCNFLPTAIKFHYIFNLRDLSNVFQGILFASPECLKGPLDLIHLWLHESARVYGDKLIDKKDCDLFQR 2768
Cdd:pfam17857 1 LIAAALAFHQKIAATFLPTAIKFHYIFNLRDFANIFQGILFSSAECLKSPLDLIRLWLHESERVYGDKMVDEKDFDLFDK 80
|
90
....*....|....*...
gi 225131082 2769 RMLETAYKYFEGIDSHML 2786
Cdd:pfam17857 81 IQMASLKKFFDDIEDELE 98
|
|
| Dynein_AAA_lid |
pfam17852 |
Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA ... |
2356-2473 |
7.30e-30 |
|
Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA domain 5 in the dynein heavy chain. This domain is composed of 8 alpha helices.
Pssm-ID: 465532 [Multi-domain] Cd Length: 126 Bit Score: 117.00 E-value: 7.30e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2356 LFDKYVPACLDKLRTSFKTITSIPESSLVQTLCVLLECLLTP-------ENVPSDSPKEVYEVYFVFACIWAFGGTLLQD 2428
Cdd:pfam17852 4 LFEWLVPPALEFVRKNCKEIVPTSDLNLVQSLCRLLESLLDEvleyngvHPLSPDKLKEYLEKLFLFALVWSIGGTLDED 83
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 225131082 2429 QisdyQADFSRWWQKEMKAVKFP--SQGTIFDYYVDHKTKKLLPWAD 2473
Cdd:pfam17852 84 S----RKKFDEFLRELFSGLDLPppEKGTVYDYFVDLEKGEWVPWSD 126
|
|
| AAA_5 |
pfam07728 |
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ... |
2176-2320 |
5.31e-10 |
|
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.
Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 60.38 E-value: 5.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2176 SVFVVGNAGTGKSKILRTLNRTYVNmkqKPVWNDLNPKAVTTDELFGFIHHATR--EWKDGKIVYSyfiglfssiLREqa 2253
Cdd:pfam07728 1 GVLLVGPPGTGKTELAERLAAALSN---RPVFYVQLTRDTTEEDLFGRRNIDPGgaSWVDGPLVRA---------ARE-- 66
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 225131082 2254 nlkhdgpKWIVLDGDID---PMWIESLNTVMDDNKVLTLASNERI-ALTPFMRLLFEIHHLR----SATPATVSR 2320
Cdd:pfam07728 67 -------GEIAVLDEINranPDVLNSLLSLLDERRLLLPDGGELVkAAPDGFRLIATMNPLDrglnELSPALRSR 134
|
|
| AAA_5 |
pfam07728 |
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ... |
2512-2648 |
1.09e-06 |
|
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.
Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 50.75 E-value: 1.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 2512 PLMLVGNAGVGKTvFVGDTLASLSEDYIVSRVPFNYYTTSTALQKILEkPLEKKAGHNYGP---GGNKKLIYFIDDMNMP 2588
Cdd:pfam07728 1 GVLLVGPPGTGKT-ELAERLAAALSNRPVFYVQLTRDTTEEDLFGRRN-IDPGGASWVDGPlvrAAREGEIAVLDEINRA 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 225131082 2589 EVDLYGTVqpHTLI---RQHIDYGHWydrqkVMLKEIHNCQYVACMNP-MVGSFTISPRLQRHF 2648
Cdd:pfam07728 79 NPDVLNSL--LSLLderRLLLPDGGE-----LVKAAPDGFRLIATMNPlDRGLNELSPALRSRF 135
|
|
| AAA_5 |
pfam07728 |
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ... |
1900-2020 |
2.29e-04 |
|
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.
Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 44.21 E-value: 2.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 1900 GPAGTGKTETTKDLGRAL-GMMVYVFNCSEQM---DYKSIGNIYKGL-----------VQTGAWGCFDEFNRISVEVLSV 1964
Cdd:pfam07728 6 GPPGTGKTELAERLAAALsNRPVFYVQLTRDTteeDLFGRRNIDPGGaswvdgplvraAREGEIAVLDEINRANPDVLNS 85
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 225131082 1965 VavqvkmiHDAIRNRKKRFVFLGEAITLKP-SVGIFITMNPGYAGRTELPENLKALF 2020
Cdd:pfam07728 86 L-------LSLLDERRLLLPDGGELVKAAPdGFRLIATMNPLDRGLNELSPALRSRF 135
|
|
| Laminin_II |
pfam06009 |
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 ... |
3330-3394 |
8.52e-04 |
|
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.
Pssm-ID: 368703 [Multi-domain] Cd Length: 138 Bit Score: 42.47 E-value: 8.52e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 225131082 3330 ANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELE 3394
Cdd:pfam06009 1 SKELAREANETAKEVLEQLAPLSQNLENTSEKLSGINRSLEETNELVNDANKALDDAGRSVKKLE 65
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
3319-3414 |
1.46e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 44.51 E-value: 1.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3319 DVEPKRQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKI 3398
Cdd:COG4372 60 ELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIA 139
|
90
....*....|....*.
gi 225131082 3399 RWGQSIKSFEAQEKTL 3414
Cdd:COG4372 140 ELQSEIAEREEELKEL 155
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
3326-3396 |
2.51e-03 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 43.67 E-value: 2.51e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 225131082 3326 ALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAK 3396
Cdd:COG3883 10 TPAFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAE 80
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
3324-3414 |
2.76e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 43.35 E-value: 2.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3324 RQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQS 3403
Cdd:COG4372 51 REELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQ 130
|
90
....*....|.
gi 225131082 3404 IKSFEAQEKTL 3414
Cdd:COG4372 131 RKQLEAQIAEL 141
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
3324-3414 |
5.56e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 42.58 E-value: 5.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3324 RQALAQANLELAAATEKLEAIRKKLVDLDRNLSRLTASFEKATAEKVRCQEEVNQTNKTIKLANRLVKELEAKKIRWGQS 3403
Cdd:COG4372 79 EEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQ 158
|
90
....*....|.
gi 225131082 3404 IKSFEAQEKTL 3414
Cdd:COG4372 159 LESLQEELAAL 169
|
|
| Surf_Exclu_PgrA |
TIGR04320 |
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ... |
3111-3205 |
7.17e-03 |
|
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.
Pssm-ID: 275124 [Multi-domain] Cd Length: 356 Bit Score: 42.02 E-value: 7.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225131082 3111 QKLKTTASQVGDLKARLASQEAEL-QLRNHDAEALITKIGLQTEKVSREKTIADAEER--KVTAIQTEVFQKQ-RECEAD 3186
Cdd:TIGR04320 247 TPIPNPPNSLAALQAKLATAQADLaAAQTALNTAQAALTSAQTAYAAAQAALATAQKElaNAQAQALQTAQNNlATAQAA 326
|
90
....*....|....*....
gi 225131082 3187 LLKAEPALVAATAALNTLN 3205
Cdd:TIGR04320 327 LANAEARLAKAKEALANLN 345
|
|
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