reelin, partial [Terrapene coahuila]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Reelin_subrepeat_like super family | cl15240 | Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein ... |
1-21 | 2.33e-06 | ||
Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns. The actual alignment was detected with superfamily member cd10052: Pssm-ID: 197448 [Multi-domain] Cd Length: 161 Bit Score: 39.78 E-value: 2.33e-06
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| Name | Accession | Description | Interval | E-value | ||
| Reelin_repeat_8_subrepeat_2 | cd10052 | C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ... |
1-21 | 2.33e-06 | ||
C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 39.78 E-value: 2.33e-06
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| Name | Accession | Description | Interval | E-value | ||
| Reelin_repeat_8_subrepeat_2 | cd10052 | C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ... |
1-21 | 2.33e-06 | ||
C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 39.78 E-value: 2.33e-06
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| Reelin_subrepeat_2 | cd08526 | C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an ... |
4-21 | 3.83e-03 | ||
C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 30.66 E-value: 3.83e-03
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