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Conserved domains on  [gi|254733133|gb|ACT79986|]
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ApxIVA [Actinobacillus pleuropneumoniae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RTX_C super family cl07086
RTX C-terminal domain; This family describes the C-terminal region of various bacterial ...
 1857-1950 2.44e-06

RTX C-terminal domain; This family describes the C-terminal region of various bacterial haemolysins and leukotoxins, which belong to the RTX family of toxins. These are produced by various Gram negative bacteria, such as E. coli and Actinobacillus pleuropneumoniae. RTX toxins may interact with lipopolysaccharide (LPS) to functionally impair and eventually kill leukocytes. This region is found in association with the RTX N-terminal domain (pfam02382) and multiple hemolysin-type calcium-binding repeats (pfam00353).


The actual alignment was detected with superfamily member pfam08339:

Pssm-ID: 429930  Cd Length: 131  Bit Score: 48.74  E-value: 2.44e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254733133  1857 FTDINLSELWFSRENNDLIIKSLLSEDKVTVQNWY----------SHQDHKIENIRLSNEQTLVSTQVEKMVEsmagfaQ 1926
Cdd:pfam08339    2 FSDANLSDLTFERVGNGLIIKKNDDSGSITFKNWFaalsrpnyhaSGTDDKIEEIIGKNGRYITSEQVDKLLN------N 75

                           90       100
                   ....*....|....*....|....*...
gi 254733133  1927 KHGGEISLVSLEEV----KQYINSLTAA 1950
Cdd:pfam08339   76 KQSGKITSSQLQQLaqnkSNMINSTDVA 103
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 1774-1861 3.01e-06

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


:

Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 50.67  E-value: 3.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254733133 1774 LFGTDGDDNINDWGRNSVIDAGAGNDTVNGGNGDDTLIGAKGNDILRGGYGADTYIFSKGHGQDIVYEDTNNDNRARDID 1853
Cdd:COG2931   124 LTGGAGDDTLYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLTGGAGNDTLDGGGGDD 203


                  ....*...
gi 254733133 1854 TLKFTDIN 1861
Cdd:COG2931   204 TLGGGGGD 211
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 1224-1337 2.68e-05

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


:

Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 47.98  E-value: 2.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254733133 1224 LFGTDGDDDINDWGRNSVIDAGAGNDTINGSYGDDTLIGGTGNDILKGSYGADTYLFSKGHGQDVIYEYSDSANSKRDID 1303
Cdd:COG2931   133 LYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLTGGAGNDTLDGGGGDDTLGGGGGDD 212

                          90       100       110
                  ....*....|....*....|....*....|....
gi 254733133 1304 TLKFTDVNYAEVKFRRVGDDLMLFGYHDTDSVTG 1337
Cdd:COG2931   213 GLDGGDGDDGLGGGGGDDTLGGGGGGDGGGGGGG 246
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 1499-1612 2.68e-05

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


:

Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 47.98  E-value: 2.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254733133 1499 LFGTDGDDDINDWGRNSVIDAGAGNDTINGSYGDDTLIGGTGNDILKGSYGADTYLFSKGHGQDVIYEYSDSANSKRDID 1578
Cdd:COG2931   133 LYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLTGGAGNDTLDGGGGDDTLGGGGGDD 212

                          90       100       110
                  ....*....|....*....|....*....|....
gi 254733133 1579 TLKFTDVNYAEVKFRRVGDDLMLFGYHDTDSVTG 1612
Cdd:COG2931   213 GLDGGDGDDGLGGGGGDDTLGGGGGGDGGGGGGG 246
Peptidase_M10_C super family cl23859
Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix ...
 1093-1163 8.13e-05

Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix metallopeptidases (MMPs). The peptidase unit is found at the N terminal while this domain at the C terminal forms a corkscrew and is thought to be important for secretion of the protein through the bacterial cell wall. This domain contains the calcium ion binding domain pfam00353.


The actual alignment was detected with superfamily member pfam08548:

Pssm-ID: 451582 [Multi-domain]  Cd Length: 222  Bit Score: 46.21  E-value: 8.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254733133  1093 NNILLGSQKDNNLSGSAGDDLLIGGEGNDTLKGSYGADTYLF-----SKGHGQDVIYEYSdSANSKSD-------IDTLK 1160
Cdd:pfam08548   90 NDVLIGNDADNILKGGAGNDILYGGGGADQLWGGAGNDIFVYasakdSLTAAPDTIRDFV-SGIDKIDlsalnnnSDGLQ 168


                   ...
gi 254733133  1161 FTD 1163
Cdd:pfam08548  169 FVD 171
 
Name Accession Description Interval E-value
RTX_C pfam08339
RTX C-terminal domain; This family describes the C-terminal region of various bacterial ...
 1857-1950 2.44e-06

RTX C-terminal domain; This family describes the C-terminal region of various bacterial haemolysins and leukotoxins, which belong to the RTX family of toxins. These are produced by various Gram negative bacteria, such as E. coli and Actinobacillus pleuropneumoniae. RTX toxins may interact with lipopolysaccharide (LPS) to functionally impair and eventually kill leukocytes. This region is found in association with the RTX N-terminal domain (pfam02382) and multiple hemolysin-type calcium-binding repeats (pfam00353).


Pssm-ID: 429930  Cd Length: 131  Bit Score: 48.74  E-value: 2.44e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254733133  1857 FTDINLSELWFSRENNDLIIKSLLSEDKVTVQNWY----------SHQDHKIENIRLSNEQTLVSTQVEKMVEsmagfaQ 1926
Cdd:pfam08339    2 FSDANLSDLTFERVGNGLIIKKNDDSGSITFKNWFaalsrpnyhaSGTDDKIEEIIGKNGRYITSEQVDKLLN------N 75

                           90       100
                   ....*....|....*....|....*...
gi 254733133  1927 KHGGEISLVSLEEV----KQYINSLTAA 1950
Cdd:pfam08339   76 KQSGKITSSQLQQLaqnkSNMINSTDVA 103
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 1774-1861 3.01e-06

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 50.67  E-value: 3.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254733133 1774 LFGTDGDDNINDWGRNSVIDAGAGNDTVNGGNGDDTLIGAKGNDILRGGYGADTYIFSKGHGQDIVYEDTNNDNRARDID 1853
Cdd:COG2931   124 LTGGAGDDTLYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLTGGAGNDTLDGGGGDD 203


                  ....*...
gi 254733133 1854 TLKFTDIN 1861
Cdd:COG2931   204 TLGGGGGD 211
HemolysinCabind pfam00353
RTX calcium-binding nonapeptide repeat (4 copies);
1793-1827 1.40e-05

RTX calcium-binding nonapeptide repeat (4 copies);


Pssm-ID: 459777 [Multi-domain]  Cd Length: 36  Bit Score: 43.58  E-value: 1.40e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 254733133  1793 DAGAGNDTVNGGNGDDTLIGAKGNDILRGGYGADT 1827
Cdd:pfam00353    1 YGGDGNDTLVGGAGNDTIYGGAGNDTLDGGAGNDT 35
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 1224-1337 2.68e-05

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 47.98  E-value: 2.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254733133 1224 LFGTDGDDDINDWGRNSVIDAGAGNDTINGSYGDDTLIGGTGNDILKGSYGADTYLFSKGHGQDVIYEYSDSANSKRDID 1303
Cdd:COG2931   133 LYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLTGGAGNDTLDGGGGDDTLGGGGGDD 212

                          90       100       110
                  ....*....|....*....|....*....|....
gi 254733133 1304 TLKFTDVNYAEVKFRRVGDDLMLFGYHDTDSVTG 1337
Cdd:COG2931   213 GLDGGDGDDGLGGGGGDDTLGGGGGGDGGGGGGG 246
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 1499-1612 2.68e-05

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 47.98  E-value: 2.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254733133 1499 LFGTDGDDDINDWGRNSVIDAGAGNDTINGSYGDDTLIGGTGNDILKGSYGADTYLFSKGHGQDVIYEYSDSANSKRDID 1578
Cdd:COG2931   133 LYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLTGGAGNDTLDGGGGDDTLGGGGGDD 212

                          90       100       110
                  ....*....|....*....|....*....|....
gi 254733133 1579 TLKFTDVNYAEVKFRRVGDDLMLFGYHDTDSVTG 1612
Cdd:COG2931   213 GLDGGDGDDGLGGGGGDDTLGGGGGGDGGGGGGG 246
HemolysinCabind pfam00353
RTX calcium-binding nonapeptide repeat (4 copies);
1225-1269 4.54e-05

RTX calcium-binding nonapeptide repeat (4 copies);


Pssm-ID: 459777 [Multi-domain]  Cd Length: 36  Bit Score: 42.04  E-value: 4.54e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 254733133  1225 FGTDGDDdindwgrnsVIDAGAGNDTINGSYGDDTLIGGTGNDIL 1269
Cdd:pfam00353    1 YGGDGND---------TLVGGAGNDTIYGGAGNDTLDGGAGNDTL 36
HemolysinCabind pfam00353
RTX calcium-binding nonapeptide repeat (4 copies);
1500-1544 4.54e-05

RTX calcium-binding nonapeptide repeat (4 copies);


Pssm-ID: 459777 [Multi-domain]  Cd Length: 36  Bit Score: 42.04  E-value: 4.54e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 254733133  1500 FGTDGDDdindwgrnsVIDAGAGNDTINGSYGDDTLIGGTGNDIL 1544
Cdd:pfam00353    1 YGGDGND---------TLVGGAGNDTIYGGAGNDTLDGGAGNDTL 36
Peptidase_M10_C pfam08548
Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix ...
 1093-1163 8.13e-05

Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix metallopeptidases (MMPs). The peptidase unit is found at the N terminal while this domain at the C terminal forms a corkscrew and is thought to be important for secretion of the protein through the bacterial cell wall. This domain contains the calcium ion binding domain pfam00353.


Pssm-ID: 430067 [Multi-domain]  Cd Length: 222  Bit Score: 46.21  E-value: 8.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254733133  1093 NNILLGSQKDNNLSGSAGDDLLIGGEGNDTLKGSYGADTYLF-----SKGHGQDVIYEYSdSANSKSD-------IDTLK 1160
Cdd:pfam08548   90 NDVLIGNDADNILKGGAGNDILYGGGGADQLWGGAGNDIFVYasakdSLTAAPDTIRDFV-SGIDKIDlsalnnnSDGLQ 168


                   ...
gi 254733133  1161 FTD 1163
Cdd:pfam08548  169 FVD 171
 
Name Accession Description Interval E-value
RTX_C pfam08339
RTX C-terminal domain; This family describes the C-terminal region of various bacterial ...
 1857-1950 2.44e-06

RTX C-terminal domain; This family describes the C-terminal region of various bacterial haemolysins and leukotoxins, which belong to the RTX family of toxins. These are produced by various Gram negative bacteria, such as E. coli and Actinobacillus pleuropneumoniae. RTX toxins may interact with lipopolysaccharide (LPS) to functionally impair and eventually kill leukocytes. This region is found in association with the RTX N-terminal domain (pfam02382) and multiple hemolysin-type calcium-binding repeats (pfam00353).


Pssm-ID: 429930  Cd Length: 131  Bit Score: 48.74  E-value: 2.44e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254733133  1857 FTDINLSELWFSRENNDLIIKSLLSEDKVTVQNWY----------SHQDHKIENIRLSNEQTLVSTQVEKMVEsmagfaQ 1926
Cdd:pfam08339    2 FSDANLSDLTFERVGNGLIIKKNDDSGSITFKNWFaalsrpnyhaSGTDDKIEEIIGKNGRYITSEQVDKLLN------N 75

                           90       100
                   ....*....|....*....|....*...
gi 254733133  1927 KHGGEISLVSLEEV----KQYINSLTAA 1950
Cdd:pfam08339   76 KQSGKITSSQLQQLaqnkSNMINSTDVA 103
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 1774-1861 3.01e-06

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 50.67  E-value: 3.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254733133 1774 LFGTDGDDNINDWGRNSVIDAGAGNDTVNGGNGDDTLIGAKGNDILRGGYGADTYIFSKGHGQDIVYEDTNNDNRARDID 1853
Cdd:COG2931   124 LTGGAGDDTLYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLTGGAGNDTLDGGGGDD 203


                  ....*...
gi 254733133 1854 TLKFTDIN 1861
Cdd:COG2931   204 TLGGGGGD 211
HemolysinCabind pfam00353
RTX calcium-binding nonapeptide repeat (4 copies);
1793-1827 1.40e-05

RTX calcium-binding nonapeptide repeat (4 copies);


Pssm-ID: 459777 [Multi-domain]  Cd Length: 36  Bit Score: 43.58  E-value: 1.40e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 254733133  1793 DAGAGNDTVNGGNGDDTLIGAKGNDILRGGYGADT 1827
Cdd:pfam00353    1 YGGDGNDTLVGGAGNDTIYGGAGNDTLDGGAGNDT 35
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 1224-1337 2.68e-05

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 47.98  E-value: 2.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254733133 1224 LFGTDGDDDINDWGRNSVIDAGAGNDTINGSYGDDTLIGGTGNDILKGSYGADTYLFSKGHGQDVIYEYSDSANSKRDID 1303
Cdd:COG2931   133 LYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLTGGAGNDTLDGGGGDDTLGGGGGDD 212

                          90       100       110
                  ....*....|....*....|....*....|....
gi 254733133 1304 TLKFTDVNYAEVKFRRVGDDLMLFGYHDTDSVTG 1337
Cdd:COG2931   213 GLDGGDGDDGLGGGGGDDTLGGGGGGDGGGGGGG 246
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 1499-1612 2.68e-05

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 47.98  E-value: 2.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254733133 1499 LFGTDGDDDINDWGRNSVIDAGAGNDTINGSYGDDTLIGGTGNDILKGSYGADTYLFSKGHGQDVIYEYSDSANSKRDID 1578
Cdd:COG2931   133 LYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLTGGAGNDTLDGGGGDDTLGGGGGDD 212

                          90       100       110
                  ....*....|....*....|....*....|....
gi 254733133 1579 TLKFTDVNYAEVKFRRVGDDLMLFGYHDTDSVTG 1612
Cdd:COG2931   213 GLDGGDGDDGLGGGGGDDTLGGGGGGDGGGGGGG 246
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 1224-1311 3.49e-05

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 47.59  E-value: 3.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254733133 1224 LFGTDGDDDINDWGRNSVIDAGAGNDTINGSYGDDTLIGGTGNDILKGSYGADTYLFSKGHGQDVIYEYSDSANSKRDID 1303
Cdd:COG2931   124 LTGGAGDDTLYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLTGGAGNDTLDGGGGDD 203


                  ....*...
gi 254733133 1304 TLKFTDVN 1311
Cdd:COG2931   204 TLGGGGGD 211
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 1499-1586 3.49e-05

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 47.59  E-value: 3.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254733133 1499 LFGTDGDDDINDWGRNSVIDAGAGNDTINGSYGDDTLIGGTGNDILKGSYGADTYLFSKGHGQDVIYEYSDSANSKRDID 1578
Cdd:COG2931   124 LTGGAGDDTLYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLTGGAGNDTLDGGGGDD 203


                  ....*...
gi 254733133 1579 TLKFTDVN 1586
Cdd:COG2931   204 TLGGGGGD 211
HemolysinCabind pfam00353
RTX calcium-binding nonapeptide repeat (4 copies);
1225-1269 4.54e-05

RTX calcium-binding nonapeptide repeat (4 copies);


Pssm-ID: 459777 [Multi-domain]  Cd Length: 36  Bit Score: 42.04  E-value: 4.54e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 254733133  1225 FGTDGDDdindwgrnsVIDAGAGNDTINGSYGDDTLIGGTGNDIL 1269
Cdd:pfam00353    1 YGGDGND---------TLVGGAGNDTIYGGAGNDTLDGGAGNDTL 36
HemolysinCabind pfam00353
RTX calcium-binding nonapeptide repeat (4 copies);
1500-1544 4.54e-05

RTX calcium-binding nonapeptide repeat (4 copies);


Pssm-ID: 459777 [Multi-domain]  Cd Length: 36  Bit Score: 42.04  E-value: 4.54e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 254733133  1500 FGTDGDDdindwgrnsVIDAGAGNDTINGSYGDDTLIGGTGNDIL 1544
Cdd:pfam00353    1 YGGDGND---------TLVGGAGNDTIYGGAGNDTLDGGAGNDTL 36
HemolysinCabind pfam00353
RTX calcium-binding nonapeptide repeat (4 copies);
1775-1819 5.52e-05

RTX calcium-binding nonapeptide repeat (4 copies);


Pssm-ID: 459777 [Multi-domain]  Cd Length: 36  Bit Score: 42.04  E-value: 5.52e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 254733133  1775 FGTDGDDnindwgrnsVIDAGAGNDTVNGGNGDDTLIGAKGNDIL 1819
Cdd:pfam00353    1 YGGDGND---------TLVGGAGNDTIYGGAGNDTLDGGAGNDTL 36
Peptidase_M10_C pfam08548
Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix ...
 1093-1163 8.13e-05

Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix metallopeptidases (MMPs). The peptidase unit is found at the N terminal while this domain at the C terminal forms a corkscrew and is thought to be important for secretion of the protein through the bacterial cell wall. This domain contains the calcium ion binding domain pfam00353.


Pssm-ID: 430067 [Multi-domain]  Cd Length: 222  Bit Score: 46.21  E-value: 8.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254733133  1093 NNILLGSQKDNNLSGSAGDDLLIGGEGNDTLKGSYGADTYLF-----SKGHGQDVIYEYSdSANSKSD-------IDTLK 1160
Cdd:pfam08548   90 NDVLIGNDADNILKGGAGNDILYGGGGADQLWGGAGNDIFVYasakdSLTAAPDTIRDFV-SGIDKIDlsalnnnSDGLQ 168


                   ...
gi 254733133  1161 FTD 1163
Cdd:pfam08548  169 FVD 171
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 1774-1861 8.92e-05

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 46.44  E-value: 8.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254733133 1774 LFGTDGDDNINDWGRNSVIDAGAGNDTVNGGNGDDTLIGAKGNDILRGGYGADTYIFSKGHGQDIVYEDTNNDNRARDID 1853
Cdd:COG2931   142 LTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLTGGAGNDTLDGGGGDDTLGGGGGDDGLDGGDGDD 221


                  ....*...
gi 254733133 1854 TLKFTDIN 1861
Cdd:COG2931   222 GLGGGGGD 229
HemolysinCabind pfam00353
RTX calcium-binding nonapeptide repeat (4 copies);
1243-1277 1.08e-04

RTX calcium-binding nonapeptide repeat (4 copies);


Pssm-ID: 459777 [Multi-domain]  Cd Length: 36  Bit Score: 40.88  E-value: 1.08e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 254733133  1243 DAGAGNDTINGSYGDDTLIGGTGNDILKGSYGADT 1277
Cdd:pfam00353    1 YGGDGNDTLVGGAGNDTIYGGAGNDTLDGGAGNDT 35
HemolysinCabind pfam00353
RTX calcium-binding nonapeptide repeat (4 copies);
1518-1552 1.08e-04

RTX calcium-binding nonapeptide repeat (4 copies);


Pssm-ID: 459777 [Multi-domain]  Cd Length: 36  Bit Score: 40.88  E-value: 1.08e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 254733133  1518 DAGAGNDTINGSYGDDTLIGGTGNDILKGSYGADT 1552
Cdd:pfam00353    1 YGGDGNDTLVGGAGNDTIYGGAGNDTLDGGAGNDT 35
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 1773-1846 6.34e-04

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 43.74  E-value: 6.34e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254733133 1773 ALFGTDGDDNINDWGRNSVIDAGAGNDTVNGGNGDDTLIGAKGNDILRGGYGADTYIFskGHGQDIVYEDTNND 1846
Cdd:COG2931   105 TGDGGGGNDTLTGGDGNDTLTGGAGDDTLYGGAGNDTLTGGAGNDTLYGGAGNDTLYG--GAGNDTLDGGAGND 176
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 1774-1863 1.31e-03

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 42.59  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254733133 1774 LFGTDGDDNINDWGRNSVIDAGAGNDTVNGGNGDDTLIGAKGNDILRGGYGADTYIFSKGHGQDIVYEDTNNDNRARDID 1853
Cdd:COG2931   151 LYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLTGGAGNDTLDGGGGDDTLGGGGGDDGLDGGDGDDGLGGGGGDD 230

                          90
                  ....*....|
gi 254733133 1854 TLKFTDINLS 1863
Cdd:COG2931   231 TLGGGGGGDG 240
Peptidase_M10_C pfam08548
Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix ...
 1245-1301 1.39e-03

Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix metallopeptidases (MMPs). The peptidase unit is found at the N terminal while this domain at the C terminal forms a corkscrew and is thought to be important for secretion of the protein through the bacterial cell wall. This domain contains the calcium ion binding domain pfam00353.


Pssm-ID: 430067 [Multi-domain]  Cd Length: 222  Bit Score: 42.36  E-value: 1.39e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 254733133  1245 GAGNDTINGSYGDDTLIGGTGNDILKGSYGADTylFSKGHGQDvIYEYSDSANSKRD 1301
Cdd:pfam08548   87 GSGNDVLIGNDADNILKGGAGNDILYGGGGADQ--LWGGAGND-IFVYASAKDSLTA 140
Peptidase_M10_C pfam08548
Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix ...
 1520-1576 1.39e-03

Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix metallopeptidases (MMPs). The peptidase unit is found at the N terminal while this domain at the C terminal forms a corkscrew and is thought to be important for secretion of the protein through the bacterial cell wall. This domain contains the calcium ion binding domain pfam00353.


Pssm-ID: 430067 [Multi-domain]  Cd Length: 222  Bit Score: 42.36  E-value: 1.39e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 254733133  1520 GAGNDTINGSYGDDTLIGGTGNDILKGSYGADTylFSKGHGQDvIYEYSDSANSKRD 1576
Cdd:pfam08548   87 GSGNDVLIGNDADNILKGGAGNDILYGGGGADQ--LWGGAGND-IFVYASAKDSLTA 140
Peptidase_M10_C pfam08548
Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix ...
 1500-1584 2.28e-03

Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix metallopeptidases (MMPs). The peptidase unit is found at the N terminal while this domain at the C terminal forms a corkscrew and is thought to be important for secretion of the protein through the bacterial cell wall. This domain contains the calcium ion binding domain pfam00353.


Pssm-ID: 430067 [Multi-domain]  Cd Length: 222  Bit Score: 41.59  E-value: 2.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254733133  1500 FGTDGDDDINDWGRNSVIDAGAGNDTINGSYGDDTLIGGTGNDILKGSYGADtylfSKGHGQDVIYEYSdSANSKRD--- 1576
Cdd:pfam08548   85 IGGSGNDVLIGNDADNILKGGAGNDILYGGGGADQLWGGAGNDIFVYASAKD----SLTAAPDTIRDFV-SGIDKIDlsa 159

                           90
                   ....*....|..
gi 254733133  1577 ----IDTLKFTD 1584
Cdd:pfam08548  160 lnnnSDGLQFVD 171
Peptidase_M10_C pfam08548
Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix ...
 1225-1309 2.28e-03

Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix metallopeptidases (MMPs). The peptidase unit is found at the N terminal while this domain at the C terminal forms a corkscrew and is thought to be important for secretion of the protein through the bacterial cell wall. This domain contains the calcium ion binding domain pfam00353.


Pssm-ID: 430067 [Multi-domain]  Cd Length: 222  Bit Score: 41.59  E-value: 2.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254733133  1225 FGTDGDDDINDWGRNSVIDAGAGNDTINGSYGDDTLIGGTGNDILKGSYGADtylfSKGHGQDVIYEYSdSANSKRD--- 1301
Cdd:pfam08548   85 IGGSGNDVLIGNDADNILKGGAGNDILYGGGGADQLWGGAGNDIFVYASAKD----SLTAAPDTIRDFV-SGIDKIDlsa 159

                           90
                   ....*....|..
gi 254733133  1302 ----IDTLKFTD 1309
Cdd:pfam08548  160 lnnnSDGLQFVD 171
HemolysinCabind pfam00353
RTX calcium-binding nonapeptide repeat (4 copies);
1089-1123 2.76e-03

RTX calcium-binding nonapeptide repeat (4 copies);


Pssm-ID: 459777 [Multi-domain]  Cd Length: 36  Bit Score: 37.03  E-value: 2.76e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 254733133  1089 GDEKNNILLGSQKDNNLSGSAGDDLLIGGEGNDTL 1123
Cdd:pfam00353    2 GGDGNDTLVGGAGNDTIYGGAGNDTLDGGAGNDTL 36
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 1724-1846 3.39e-03

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 41.43  E-value: 3.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254733133 1724 VDNDLMLFGYHDTDLVTVKSFYSHVDYKFDKLEFADRSITRDELGKQGMALFGTDGDDNINDWGRNSVIDAGAGNDTVNG 1803
Cdd:COG2931    47 GGGDGGGGGGGGGGGGGGGGLDGGGGGGGGDGGGGGGGDDTDGGGDGGDGGGGGTGDDTGDGGGGNDTLTGGDGNDTLTG 126

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 254733133 1804 GNGDDTLIGAKGNDILRGGYGADTYIFskGHGQDIVYEDTNND 1846
Cdd:COG2931   127 GAGDDTLYGGAGNDTLTGGAGNDTLYG--GAGNDTLYGGAGND 167
Peptidase_M10_C pfam08548
Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix ...
 1795-1849 6.58e-03

Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix metallopeptidases (MMPs). The peptidase unit is found at the N terminal while this domain at the C terminal forms a corkscrew and is thought to be important for secretion of the protein through the bacterial cell wall. This domain contains the calcium ion binding domain pfam00353.


Pssm-ID: 430067 [Multi-domain]  Cd Length: 222  Bit Score: 40.05  E-value: 6.58e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 254733133  1795 GAGNDTVNGGNGDDTLIGAKGNDILRGGYGADTyiFSKGHGQDI-VYEDTNNDNRA 1849
Cdd:pfam08548   87 GSGNDVLIGNDADNILKGGAGNDILYGGGGADQ--LWGGAGNDIfVYASAKDSLTA 140
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 1498-1552 7.63e-03

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 40.27  E-value: 7.63e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 254733133 1498 ALFGTDGDDDINDWGRNSVIDAGAGNDTINGSYGDDTLIGGTGNDILKGSYGADT 1552
Cdd:COG2931   105 TGDGGGGNDTLTGGDGNDTLTGGAGDDTLYGGAGNDTLTGGAGNDTLYGGAGNDT 159
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 1223-1277 7.63e-03

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 40.27  E-value: 7.63e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 254733133 1223 ALFGTDGDDDINDWGRNSVIDAGAGNDTINGSYGDDTLIGGTGNDILKGSYGADT 1277
Cdd:COG2931   105 TGDGGGGNDTLTGGDGNDTLTGGAGDDTLYGGAGNDTLTGGAGNDTLYGGAGNDT 159
HemolysinCabind pfam00353
RTX calcium-binding nonapeptide repeat (4 copies);
1803-1834 8.57e-03

RTX calcium-binding nonapeptide repeat (4 copies);


Pssm-ID: 459777 [Multi-domain]  Cd Length: 36  Bit Score: 35.88  E-value: 8.57e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 254733133  1803 GGNGDDTLIGAKGNDILRGGYGADTYIFSKGH 1834
Cdd:pfam00353    2 GGDGNDTLVGGAGNDTIYGGAGNDTLDGGAGN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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