NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|257362209|gb|ACV53189|]
View 

DNA gyrase subunit A, partial [Actinobacillus pleuropneumoniae]

Protein Classification

DNA gyrase subunit A family protein( domain architecture ID 1000081)

DNA gyrase subunit A (GyrA) forms a 2:2 heterotetrameric complex with GyrB to form gyrase, a type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state; may be partial

CATH:  1.10.268.10|3.90.199.10
PubMed:  11395412|9519293|17397985

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK05560 super family cl35335
DNA gyrase subunit A; Validated
 5-194 2.56e-159

DNA gyrase subunit A; Validated


The actual alignment was detected with superfamily member PRK05560:

Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 459.11  E-value: 2.56e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209   5 AKDITPVSIEDELKTSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFSMDQNSNTFNRPHVKSARVVGDVIGKYHPHGDYA 84
Cdd:PRK05560   2 GDRIIPVNIEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209  85 VYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDAPAAMRYTEVRMQKITQELLTDLDKETVDYSPNYDGKEMIPDVLPTKIP 164
Cdd:PRK05560  82 VYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFP 161

                        170       180       190
                 ....*....|....*....|....*....|
gi 257362209 165 ALLVNGSSGIAVGMATNIPPHNLNEVLDGC 194
Cdd:PRK05560 162 NLLVNGSSGIAVGMATNIPPHNLGEVIDAC 191
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 5-194 2.56e-159

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 459.11  E-value: 2.56e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209   5 AKDITPVSIEDELKTSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFSMDQNSNTFNRPHVKSARVVGDVIGKYHPHGDYA 84
Cdd:PRK05560   2 GDRIIPVNIEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209  85 VYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDAPAAMRYTEVRMQKITQELLTDLDKETVDYSPNYDGKEMIPDVLPTKIP 164
Cdd:PRK05560  82 VYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFP 161

                        170       180       190
                 ....*....|....*....|....*....|
gi 257362209 165 ALLVNGSSGIAVGMATNIPPHNLNEVLDGC 194
Cdd:PRK05560 162 NLLVNGSSGIAVGMATNIPPHNLGEVIDAC 191
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-194 3.00e-156

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 451.03  E-value: 3.00e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209   1 MSEL--AKDITPVSIEDELKTSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFSMDQNSNTFNRPHVKSARVVGDVIGKYH 78
Cdd:COG0188    1 MSDPppAERIIPVNLEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDKPYKKSARVVGDVMGKYH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209  79 PHGDYAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDAPAAMRYTEVRMQKITQELLTDLDKETVDYSPNYDGKEMIPDV 158
Cdd:COG0188   81 PHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEPTV 160

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 257362209 159 LPTKIPALLVNGSSGIAVGMATNIPPHNLNEVLDGC 194
Cdd:COG0188  161 LPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDAC 196
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 8-194 2.81e-138

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 404.77  E-value: 2.81e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209    8 ITPVSIEDELKTSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFSMDQNSNTFNRPHVKSARVVGDVIGKYHPHGDYAVYD 87
Cdd:TIGR01063   1 IVPVNIEEEMKRSYLDYAMSVIVSRALPDVRDGLKPVHRRILYAMYELGLTPDKPYKKSARIVGDVMGKYHPHGDSAIYD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209   88 TIVRMAQPFSLRYMLVDGQGNFGSIDGDAPAAMRYTEVRMQKITQELLTDLDKETVDYSPNYDGKEMIPDVLPTKIPALL 167
Cdd:TIGR01063  81 TLVRMAQDFSLRYPLVDGQGNFGSIDGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLL 160

                         170       180
                  ....*....|....*....|....*..
gi 257362209  168 VNGSSGIAVGMATNIPPHNLNEVLDGC 194
Cdd:TIGR01063 161 VNGSSGIAVGMATNIPPHNLGEIIDAL 187
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 11-194 3.63e-122

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 352.25  E-value: 3.63e-122
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209    11 VSIEDELKTSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFSMDQNSNTFNRPHVKSARVVGDVIGKYHPHGDYAVYDTIV 90
Cdd:smart00434   1 IDIEDFINKEYLDYSMSVINGRAIPDVRDGLKPVQRRILYAMFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209    91 RMAQPFSLRYMLVDGQGNFGSI-DGDAPAAMRYTEVRMQKITQELLTDLDKETVDYSPNYDGKEMIPDVLPTKIPALLVN 169
Cdd:smart00434  81 RMAQDFSNNYPLLDGQGNFGSRlDGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVN 160

                          170       180
                   ....*....|....*....|....*
gi 257362209   170 GSSGIAVGMATNIPPHNLNEVLDGC 194
Cdd:smart00434 161 GSSGIAVGMATNIPPHNLREVIDAV 185
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 30-194 4.14e-115

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 334.54  E-value: 4.14e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209  30 VGRALPDVRDGLKPVHRRVLFSMDQNSNTFNRPHVKSARVVGDVIGKYHPHGDYAVYDTIVRMAQPFSLRYMLVDGQGNF 109
Cdd:cd00187    1 NGRALPDVRDGLKPVQRRILYAMFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209 110 GSIDGDAPAAMRYTEVRMQKITQELLTDLDKETVDYSPNYDGKEMIPDVLPTKIPALLVNGSSGIAVGMATNIPPHNLNE 189
Cdd:cd00187   81 GSRDGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLRE 160


                 ....*
gi 257362209 190 VLDGC 194
Cdd:cd00187  161 VIDAL 165
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
32-194 1.49e-106

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 312.18  E-value: 1.49e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209   32 RALPDVRDGLKPVHRRVLFSMdQNSNTFNRPHVKSARVVGDVIGKYHPHGDYAVYDTIVRMAQPFSLRYMLVDGQGNFGS 111
Cdd:pfam00521   1 RAIPDVRDGLKPVQRRILYAM-FELLNLDKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209  112 -IDGDAPAAMRYTEVRMQKITQELLTDLDKETVDYSPNYDGKEMIPDVLPTKIPALLVNGSSGIAVGMATNIPPHNLNEV 190
Cdd:pfam00521  80 rIDGDKDAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREI 159


                  ....
gi 257362209  191 LDGC 194
Cdd:pfam00521 160 IDAL 163
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 5-194 2.56e-159

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 459.11  E-value: 2.56e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209   5 AKDITPVSIEDELKTSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFSMDQNSNTFNRPHVKSARVVGDVIGKYHPHGDYA 84
Cdd:PRK05560   2 GDRIIPVNIEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209  85 VYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDAPAAMRYTEVRMQKITQELLTDLDKETVDYSPNYDGKEMIPDVLPTKIP 164
Cdd:PRK05560  82 VYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFP 161

                        170       180       190
                 ....*....|....*....|....*....|
gi 257362209 165 ALLVNGSSGIAVGMATNIPPHNLNEVLDGC 194
Cdd:PRK05560 162 NLLVNGSSGIAVGMATNIPPHNLGEVIDAC 191
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-194 3.00e-156

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 451.03  E-value: 3.00e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209   1 MSEL--AKDITPVSIEDELKTSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFSMDQNSNTFNRPHVKSARVVGDVIGKYH 78
Cdd:COG0188    1 MSDPppAERIIPVNLEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDKPYKKSARVVGDVMGKYH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209  79 PHGDYAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDAPAAMRYTEVRMQKITQELLTDLDKETVDYSPNYDGKEMIPDV 158
Cdd:COG0188   81 PHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEPTV 160

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 257362209 159 LPTKIPALLVNGSSGIAVGMATNIPPHNLNEVLDGC 194
Cdd:COG0188  161 LPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDAC 196
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 8-194 2.81e-138

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 404.77  E-value: 2.81e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209    8 ITPVSIEDELKTSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFSMDQNSNTFNRPHVKSARVVGDVIGKYHPHGDYAVYD 87
Cdd:TIGR01063   1 IVPVNIEEEMKRSYLDYAMSVIVSRALPDVRDGLKPVHRRILYAMYELGLTPDKPYKKSARIVGDVMGKYHPHGDSAIYD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209   88 TIVRMAQPFSLRYMLVDGQGNFGSIDGDAPAAMRYTEVRMQKITQELLTDLDKETVDYSPNYDGKEMIPDVLPTKIPALL 167
Cdd:TIGR01063  81 TLVRMAQDFSLRYPLVDGQGNFGSIDGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLL 160

                         170       180
                  ....*....|....*....|....*..
gi 257362209  168 VNGSSGIAVGMATNIPPHNLNEVLDGC 194
Cdd:TIGR01063 161 VNGSSGIAVGMATNIPPHNLGEIIDAL 187
PRK05561 PRK05561
DNA topoisomerase 4 subunit A;
1-194 9.49e-126

DNA topoisomerase 4 subunit A;


Pssm-ID: 235503 [Multi-domain]  Cd Length: 742  Bit Score: 370.98  E-value: 9.49e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209   1 MSELAKDITPVSIEDELKTSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFSMDQNSNTFNRPHVKSARVVGDVIGKYHPH 80
Cdd:PRK05561   3 DMSMLEGIEDLPLEEFLEERYLRYAMYVIMDRALPDVRDGLKPVQRRILYAMSELGLTPDAKFKKSARVVGDVLGKYHPH 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209  81 GDYAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDAPAAMRYTEVRMQKITQELLTDLDKETVDYSPNYDGKEMIPDVLP 160
Cdd:PRK05561  83 GDSSIYDAMVRMAQDFSYRYPLVDGQGNFGSIDGDPAAAMRYTEARLSPIAELLLEEIDEGTVDFVPNFDGTLKEPTVLP 162

                        170       180       190
                 ....*....|....*....|....*....|....
gi 257362209 161 TKIPALLVNGSSGIAVGMATNIPPHNLNEVLDGC 194
Cdd:PRK05561 163 ARFPNLLLNGATGIAVGMATDIPPHNLREVIDAA 196
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 11-194 3.63e-122

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 352.25  E-value: 3.63e-122
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209    11 VSIEDELKTSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFSMDQNSNTFNRPHVKSARVVGDVIGKYHPHGDYAVYDTIV 90
Cdd:smart00434   1 IDIEDFINKEYLDYSMSVINGRAIPDVRDGLKPVQRRILYAMFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209    91 RMAQPFSLRYMLVDGQGNFGSI-DGDAPAAMRYTEVRMQKITQELLTDLDKETVDYSPNYDGKEMIPDVLPTKIPALLVN 169
Cdd:smart00434  81 RMAQDFSNNYPLLDGQGNFGSRlDGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVN 160

                          170       180
                   ....*....|....*....|....*
gi 257362209   170 GSSGIAVGMATNIPPHNLNEVLDGC 194
Cdd:smart00434 161 GSSGIAVGMATNIPPHNLREVIDAV 185
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 30-194 4.14e-115

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 334.54  E-value: 4.14e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209  30 VGRALPDVRDGLKPVHRRVLFSMDQNSNTFNRPHVKSARVVGDVIGKYHPHGDYAVYDTIVRMAQPFSLRYMLVDGQGNF 109
Cdd:cd00187    1 NGRALPDVRDGLKPVQRRILYAMFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209 110 GSIDGDAPAAMRYTEVRMQKITQELLTDLDKETVDYSPNYDGKEMIPDVLPTKIPALLVNGSSGIAVGMATNIPPHNLNE 189
Cdd:cd00187   81 GSRDGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLRE 160


                 ....*
gi 257362209 190 VLDGC 194
Cdd:cd00187  161 VIDAL 165
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
32-194 1.49e-106

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 312.18  E-value: 1.49e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209   32 RALPDVRDGLKPVHRRVLFSMdQNSNTFNRPHVKSARVVGDVIGKYHPHGDYAVYDTIVRMAQPFSLRYMLVDGQGNFGS 111
Cdd:pfam00521   1 RAIPDVRDGLKPVQRRILYAM-FELLNLDKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209  112 -IDGDAPAAMRYTEVRMQKITQELLTDLDKETVDYSPNYDGKEMIPDVLPTKIPALLVNGSSGIAVGMATNIPPHNLNEV 190
Cdd:pfam00521  80 rIDGDKDAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREI 159


                  ....
gi 257362209  191 LDGC 194
Cdd:pfam00521 160 IDAL 163
PRK13979 PRK13979
DNA topoisomerase IV subunit A; Provisional
 3-194 1.91e-86

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 237576 [Multi-domain]  Cd Length: 957  Bit Score: 273.13  E-value: 1.91e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209   3 ELAKD--ITPVSIEDELKTSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFSMDQNSNTFNRPHVKSARVVGDVIGKYHPH 80
Cdd:PRK13979   6 VIPKDnnIIKIPLEEAMPENYLPYAVEVAKDRALPDVRDGLKPVHRRILYGAYMLKAFPDKPYYKSARIVGDILGKYHPH 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209  81 GDYAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDAPAAMRYTEVRMQKITQELLTDLDKETVDYSPNYDGKEMIPDVLP 160
Cdd:PRK13979  86 GDSSVYDAMVILAQDFTTRMPLIDGHGNWGSIDGDSAAAMRYTEARLTPIAMEMLRDIDKDVVNMVDNYSDSEKEPEVLP 165

                        170       180       190
                 ....*....|....*....|....*....|....
gi 257362209 161 TKIPALLVNGSSGIAVGMATNIPPHNLNEVLDGC 194
Cdd:PRK13979 166 ARYPNLLVNGAFGIAVGLATNIPPHNLKEVIDGT 199
parC_Gneg TIGR01062
DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II ...
 17-192 6.57e-86

DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 130134 [Multi-domain]  Cd Length: 735  Bit Score: 267.54  E-value: 6.57e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209   17 LKTSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFSMDQNSNTFNRPHVKSARVVGDVIGKYHPHGDYAVYDTIVRMAQPF 96
Cdd:TIGR01062  10 TEEAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNANAKYKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209   97 SLRYMLVDGQGNFGSIDG-DAPAAMRYTEVRMQKITQELLTDLDKETVDYSPNYDGKEMIPDVLPTKIPALLVNGSSGIA 175
Cdd:TIGR01062  90 SYRYPLVDGQGNWGAPDDpKSFAAMRYTESRLSKISELLLEELGQGTVDFRPNFDGTLLEPVILPARLPNILLNGTTGIA 169

                         170
                  ....*....|....*..
gi 257362209  176 VGMATNIPPHNLNEVLD 192
Cdd:TIGR01062 170 VGMATDIPPHNLHELAD 186
parC_Gpos TIGR01061
DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II ...
 12-192 1.61e-80

DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273422 [Multi-domain]  Cd Length: 738  Bit Score: 253.57  E-value: 1.61e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209   12 SIEDELKTSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFSMDQNSNTFNRPHVKSARVVGDVIGKYHPHGDYAVYDTIVR 91
Cdd:TIGR01061   5 PLEEVFGESFGKYAKYIIQDRALPDIRDGLKPVQRRILYAMFQDGNTFDKPYKKSARTVGEIMGKYHPHGDSSIYDAMVR 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209   92 MAQPFSLRYMLVDGQGNFGSIDGDAPAAMRYTEVRMQKITQELLTDLDKETVDYSPNYDGKEMIPDVLPTKIPALLVNGS 171
Cdd:TIGR01061  85 MSQDWKNNWTLVEMHGNNGSIDGDNAAAMRYTEARLSLIASELLKDIDKKTVSFIPNFDDSEKEPTVLPALFPNLLINGA 164

                         170       180
                  ....*....|....*....|.
gi 257362209  172 SGIAVGMATNIPPHNLNEVLD 192
Cdd:TIGR01061 165 TGIAAGYATNIPPHNLNEVID 185
PRK09631 PRK09631
DNA topoisomerase IV subunit A; Provisional
 13-191 4.20e-51

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 236598 [Multi-domain]  Cd Length: 635  Bit Score: 173.74  E-value: 4.20e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209  13 IEDELKTSYLDYAMSVIVGRALPDVRDGLKPVHRRV---LFSMDQNsntfnRPHvKSARVVGDVIgKYHPHGDYAVYDTI 89
Cdd:PRK09631   4 IKTLFKDNFLQYASYVIKDRAIPDVIDGLKPVQRRIlhsLFEMHDG-----KFH-KVANVVGNTM-KYHPHGDASIYEAL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209  90 VRMAQpfslRYMLVDGQGNFGSI-DGDAPAAMRYTEVRMQKITQELLtdLDKETVDYSPNYDGKEMIPDVLPTKIPALLV 168
Cdd:PRK09631  77 VNLAN----KDLFIDKQGNFGNLfTGDPASAARYIECRLTPLAKEVL--YNKEITEYEPSYDGRNNEPLCLPAKIPVILI 150

                        170       180
                 ....*....|....*....|...
gi 257362209 169 NGSSGIAVGMATNIPPHNLNEVL 191
Cdd:PRK09631 151 QGAEGIAVGMATKILPHNFNEIL 173
PRK12758 PRK12758
DNA gyrase/topoisomerase IV subunit A;
1-194 1.07e-45

DNA gyrase/topoisomerase IV subunit A;


Pssm-ID: 237192 [Multi-domain]  Cd Length: 869  Bit Score: 160.55  E-value: 1.07e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209   1 MSELAKDITPVSIEDEL----------KTSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFSMDQNSN-TFNrphvKSARV 69
Cdd:PRK12758   1 MSEEIENNQPEEESSEDealthvsgmyKNWFLDYASYVILERAVPHIEDGLKPVQRRILHSMKEMDDgRYN----KVANV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209  70 VGDVIgKYHPHGDYAVYDTIVRMAQpfslRYMLVDGQGNFGSI-DGDAPAAMRYTEVRMQKITQELLtdLDKETVDYSPN 148
Cdd:PRK12758  77 VGHTM-QYHPHGDASIGDALVQLGQ----KDLLIDTQGNWGNIlTGDGAAAPRYIEARLSKFALEVV--FNPKTTEWQLS 149

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 257362209 149 YDGKEMIPDVLPTKIPALLVNGSSGIAVGMATNIPPHNLNEVLDGC 194
Cdd:PRK12758 150 YDGRKKEPVTLPVKFPLLLAQGAEGIAVGLSTKILPHNFNELIDAS 195
PRK09630 PRK09630
DNA topoisomerase IV subunit A; Provisional
 13-192 3.40e-40

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 170022  Cd Length: 479  Bit Score: 141.96  E-value: 3.40e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209  13 IEDELKTSYLDYAMSVIVGRALPDVRDGLKPVHRRVL---FSMDQNsntfnRPHvKSARVVGDVIGkYHPHGDYAVYDTI 89
Cdd:PRK09630   4 VSDLFKTHFMHYASYVILERAIPHILDGLKPVQRRLLwtlFRMDDG-----KMH-KVANIAGRTMA-LHPHGDAPIVEAL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209  90 VRMAQpfslRYMLVDGQGNFGS-IDGDAPAAMRYTEVRMQKITQELL--TDLdketVDYSPNYDGKEMIPDVLPTKIPAL 166
Cdd:PRK09630  77 VVLAN----KGYLIDTQGNFGNpLTGDPHAAARYIEARLSPLAKEVLfnTDL----MTFHDSYDGREKEPDILPAKLPLL 148

                        170       180
                 ....*....|....*....|....*.
gi 257362209 167 LVNGSSGIAVGMATNIPPHNLNEVLD 192
Cdd:PRK09630 149 LLHGVDGIAVGMTTKIFPHNFCELLE 174
52 PHA02592
DNA topisomerase II medium subunit; Provisional
 12-194 7.09e-37

DNA topisomerase II medium subunit; Provisional


Pssm-ID: 222896 [Multi-domain]  Cd Length: 439  Bit Score: 132.49  E-value: 7.09e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209  12 SIEDELKTSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFS----MDQNSNTFNrphvKSARVVGDV--IGkYHpHGDYAV 85
Cdd:PHA02592   7 SLKSIVNNEALEYAMYTVEERAIPNLIDGLKPVQRFVIHRaleyAKGNKEKFD----KVAAIAGGVadLG-YH-HGETSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209  86 YDTIVRMAQPFSLRYMLVDGQGNFGSIDGDAPAAMRYTEVRMQkitqELLTDLDKETvDYSPNYDGKEMIPDV--LPTkI 163
Cdd:PHA02592  81 QDAGALMANTWNNNIPLLDGQGNFGSRLVQKAAAARYIFARVH----DNFRKIYKDE-DLAPVHEDPEHIPPAfyLPI-I 154

                        170       180       190
                 ....*....|....*....|....*....|.
gi 257362209 164 PALLVNGSSGIAVGMATNIPPHNLNEVLDGC 194
Cdd:PHA02592 155 PMVLLNGVSGIATGYATNILPHSPKSVIKAV 185
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 32-192 2.25e-24

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 99.74  E-value: 2.25e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209   32 RALPDVRDGLKPVHRRVLFSMdqnsntFNRPHVKSARVV---GDVIGK--YHpHGDYAVYDTIVRMAQPF----SLRYML 102
Cdd:PTZ00108  680 RSIPSLVDGLKPGQRKILFAC------FKRNLKNEIKVAqlsGYVSEHsaYH-HGEQSLQQTIVGMAQNFvgsnNINLLY 752

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209  103 VDGQgnFGS--IDGDAPAAMRYTEVRMQKITQELLTDLDKETVDYSpNYDGKEMIPD-VLPTkIPALLVNGSSGIAVGMA 179
Cdd:PTZ00108  753 PCGQ--FGSrlQGGKDHAAARYIFTKLSKITRYIFPEEDDPILDYL-EDDGQSVEPFyYVPI-IPMVLVNGAEGIGTGFS 828

                         170
                  ....*....|...
gi 257362209  180 TNIPPHNLNEVLD 192
Cdd:PTZ00108  829 TSIPNYNPLDIID 841
PLN03128 PLN03128
DNA topoisomerase 2; Provisional
 32-191 1.11e-20

DNA topoisomerase 2; Provisional


Pssm-ID: 215593 [Multi-domain]  Cd Length: 1135  Bit Score: 89.00  E-value: 1.11e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209   32 RALPDVRDGLKPVHRRVLFSmdqnsnTFNR---PHVKSARVVGDVI--GKYHpHGDYAVYDTIVRMAQPF--SLRYMLVD 104
Cdd:PLN03128  673 RSIPSMVDGLKPSQRKVLFA------CFKRnlkSEIKVAQLSGYVAehSAYH-HGEASLASTIIGMAQDFvgSNNINLLT 745

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209  105 GQGNFGS--IDGDAPAAMRYTEVRMQKITQELLTDLDKETVDYSpNYDGKEMIPDVLPTKIPALLVNGSSGIAVGMATNI 182
Cdd:PLN03128  746 PSGQFGTrlQGGKDAASARYIFTRLSPITRALFPKDDDVLLNYL-NEDGQSIEPEWYCPIIPMVLVNGSEGIGTGWSTFI 824


                  ....*....
gi 257362209  183 PPHNLNEVL 191
Cdd:PLN03128  825 PNYNPRDII 833
PLN03237 PLN03237
DNA topoisomerase 2; Provisional
 32-192 1.19e-19

DNA topoisomerase 2; Provisional


Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 86.07  E-value: 1.19e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209   32 RALPDVRDGLKPVHRRVLFSmdqnsnTFNRPHVKSARV---VGDV--IGKYHpHGDYAVYDTIVRMAQPF----SLRYML 102
Cdd:PLN03237  698 RSIPSMVDGLKPGQRKILFC------SFKRNFVKEAKVaqlSGYVseHSAYH-HGEQSLASTIIGMAQDFvgsnNINLLL 770

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257362209  103 VDGQGNFGSIDGDAPAAMRYTEVRMQKITQELLTDLDKETVDYSpNYDGKEMIPD-VLPTkIPALLVNGSSGIAVGMATN 181
Cdd:PLN03237  771 PNGQFGTRLQGGKDHASARYIFTRLSPITRFLFPKDDDILLDYL-NEDGQSIEPTwYMPI-IPTVLVNGAEGIGTGWSTF 848

                         170
                  ....*....|.
gi 257362209  182 IPPHNLNEVLD 192
Cdd:PLN03237  849 IPNYNPRDIVA 859
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH