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Conserved domains on  [gi|260177240|gb|ACX33960|]
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putative SAM-dependent methyltransferase type 11 [uncultured bacterium RM35]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10789277)

class I SAM-dependent methyltransferase is an enzyme that uses S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyl transfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 37-134 8.95e-23

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 90.82  E-value: 8.95e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177240  37 EAIRLASLPARAHVLDVACGSGAVALLAASAAERVEALDFSVQMLDRLREQATRQGsTNVCVREGNGQALPFPDESFDVA 116
Cdd:COG2226   13 ALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAG-LNVEFVVGDAEDLPFPDGSFDLV 91

                         90
                 ....*....|....*...
gi 260177240 117 FSMFGLQFFGDRARGLAE 134
Cdd:COG2226   92 ISSFVLHHLPDPERALAE 109
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 37-134 8.95e-23

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 90.82  E-value: 8.95e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177240  37 EAIRLASLPARAHVLDVACGSGAVALLAASAAERVEALDFSVQMLDRLREQATRQGsTNVCVREGNGQALPFPDESFDVA 116
Cdd:COG2226   13 ALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAG-LNVEFVVGDAEDLPFPDGSFDLV 91

                         90
                 ....*....|....*...
gi 260177240 117 FSMFGLQFFGDRARGLAE 134
Cdd:COG2226   92 ISSFVLHHLPDPERALAE 109
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 51-134 1.18e-16

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 73.08  E-value: 1.18e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177240   51 LDVACGSGAVALLAASAAERVEALDFSVQMLDRLREQATRQGSTNVCvreGNGQALPFPDESFDVAFSMFGLQFFGDRAR 130
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGLTFVV---GDAEDLPFPDNSFDLVLSSEVLHHVEDPER 77


                  ....
gi 260177240  131 GLAE 134
Cdd:pfam08241  78 ALRE 81
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 37-205 2.14e-16

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 76.35  E-value: 2.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177240  37 EAIRLASLPARAHVLDVACGSG---AVALLAASAAERVEALDFSVQMLDRLREQATRQG-STNVCVREGNGQALPFPDES 112
Cdd:PRK00216  42 KTIKWLGVRPGDKVLDLACGTGdlaIALAKAVGKTGEVVGLDFSEGMLAVGREKLRDLGlSGNVEFVQGDAEALPFPDNS 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177240 113 FDVAfSM-FGLQFFGDRARGLAELRRVLRRGGRAVIgC------WAPQDRIH---------PMGEL----------LAEM 166
Cdd:PRK00216 122 FDAV-TIaFGLRNVPDIDKALREMYRVLKPGGRLVI-LefskptNPPLKKAYdfylfkvlpLIGKLisknaeaysyLAES 199

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 260177240 167 ARRFPGlpfgkfrvplgeKAEVETEMSAAGFSGVTVHSF 205
Cdd:PRK00216 200 IRAFPD------------QEELAAMLEEAGFERVRYRNL 226
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 37-134 7.55e-13

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 66.13  E-value: 7.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177240   37 EAIRLASLPARAHVLDVACGSG---AVALLAASAAERVEALDFSVQMLDRLREQATRQGstNVCVREGNGQALPFPDESF 113
Cdd:TIGR01934  30 RAVKLIGVFKGQKVLDVACGTGdlaIELAKSAPDRGKVTGVDFSSEMLEVAKKKSELPL--NIEFIQADAEALPFEDNSF 107

                          90       100
                  ....*....|....*....|.
gi 260177240  114 DVAFSMFGLQFFGDRARGLAE 134
Cdd:TIGR01934 108 DAVTIAFGLRNVTDIQKALRE 128
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 50-134 1.21e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 43.19  E-value: 1.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177240  50 VLDVACGSGAVALL-AASAAERVEALDFSVQMLDRLREQATRQGSTNVCVREGNG-QALPFPDESFDVAFSMFGLQFFGD 127
Cdd:cd02440    2 VLDLGCGTGALALAlASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAeELPPEADESFDVIISDPPLHHLVE 81


                 ....*..
gi 260177240 128 RARGLAE 134
Cdd:cd02440   82 DLARFLE 88
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 37-134 8.95e-23

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 90.82  E-value: 8.95e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177240  37 EAIRLASLPARAHVLDVACGSGAVALLAASAAERVEALDFSVQMLDRLREQATRQGsTNVCVREGNGQALPFPDESFDVA 116
Cdd:COG2226   13 ALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAG-LNVEFVVGDAEDLPFPDGSFDLV 91

                         90
                 ....*....|....*...
gi 260177240 117 FSMFGLQFFGDRARGLAE 134
Cdd:COG2226   92 ISSFVLHHLPDPERALAE 109
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 51-134 1.18e-16

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 73.08  E-value: 1.18e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177240   51 LDVACGSGAVALLAASAAERVEALDFSVQMLDRLREQATRQGSTNVCvreGNGQALPFPDESFDVAFSMFGLQFFGDRAR 130
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGLTFVV---GDAEDLPFPDNSFDLVLSSEVLHHVEDPER 77


                  ....
gi 260177240  131 GLAE 134
Cdd:pfam08241  78 ALRE 81
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 50-134 1.42e-16

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 72.98  E-value: 1.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177240   50 VLDVACGSGAVALL-AASAAERVEALDFSVQMLDRLREQATRQGsTNVCVREGNGQALPFPDESFDVAFSMFGLQFFG-- 126
Cdd:pfam13649   1 VLDLGCGTGRLTLAlARRGGARVTGVDLSPEMLERARERAAEAG-LNVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLPdp 79


                  ....*...
gi 260177240  127 DRARGLAE 134
Cdd:pfam13649  80 DLEAALRE 87
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 37-205 2.14e-16

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 76.35  E-value: 2.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177240  37 EAIRLASLPARAHVLDVACGSG---AVALLAASAAERVEALDFSVQMLDRLREQATRQG-STNVCVREGNGQALPFPDES 112
Cdd:PRK00216  42 KTIKWLGVRPGDKVLDLACGTGdlaIALAKAVGKTGEVVGLDFSEGMLAVGREKLRDLGlSGNVEFVQGDAEALPFPDNS 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177240 113 FDVAfSM-FGLQFFGDRARGLAELRRVLRRGGRAVIgC------WAPQDRIH---------PMGEL----------LAEM 166
Cdd:PRK00216 122 FDAV-TIaFGLRNVPDIDKALREMYRVLKPGGRLVI-LefskptNPPLKKAYdfylfkvlpLIGKLisknaeaysyLAES 199

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 260177240 167 ARRFPGlpfgkfrvplgeKAEVETEMSAAGFSGVTVHSF 205
Cdd:PRK00216 200 IRAFPD------------QEELAAMLEEAGFERVRYRNL 226
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 35-134 6.16e-13

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 64.27  E-value: 6.16e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177240  35 AMEAIRLASLPARAHVLDVACGSGAVALLAASAAERVEALDFSVQMLDRLREQATRQgstNVCVREGNGQALPFPDESFD 114
Cdd:COG2227   13 RLAALLARLLPAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAEL---NVDFVQGDLEDLPLEDGSFD 89

                         90       100
                 ....*....|....*....|
gi 260177240 115 VAFSMFGLQFFGDRARGLAE 134
Cdd:COG2227   90 LVICSEVLEHLPDPAALLRE 109
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 37-134 7.55e-13

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 66.13  E-value: 7.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177240   37 EAIRLASLPARAHVLDVACGSG---AVALLAASAAERVEALDFSVQMLDRLREQATRQGstNVCVREGNGQALPFPDESF 113
Cdd:TIGR01934  30 RAVKLIGVFKGQKVLDVACGTGdlaIELAKSAPDRGKVTGVDFSSEMLEVAKKKSELPL--NIEFIQADAEALPFEDNSF 107

                          90       100
                  ....*....|....*....|.
gi 260177240  114 DVAFSMFGLQFFGDRARGLAE 134
Cdd:TIGR01934 108 DAVTIAFGLRNVTDIQKALRE 128
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
48-134 5.96e-12

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 63.61  E-value: 5.96e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177240   48 AHVLDVACGSGAVALLAASAAE---RVEALDFSVQMLDRLREQATRQGSTNVCVREGNGQALPFPDESFDVAFSMFGLQF 124
Cdd:pfam01209  44 NKFLDVAGGTGDWTFGLSDSAGssgKVVGLDINENMLKEGEKKAKEEGKYNIEFLQGNAEELPFEDDSFDIVTISFGLRN 123

                          90
                  ....*....|
gi 260177240  125 FGDRARGLAE 134
Cdd:pfam01209 124 FPDYLKVLKE 133
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 33-130 2.56e-10

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 58.39  E-value: 2.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177240  33 HFAMEAIRLASLPARAHVLDVACGSGAVALL-AASAAERVEALDFSVQMLDRLREQATRQGSTNVCVREGN-GQALPFPD 110
Cdd:COG0500   13 GLAALLALLERLPKGGRVLDLGCGTGRNLLAlAARFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVADlAELDPLPA 92

                         90       100
                 ....*....|....*....|
gi 260177240 111 ESFDVAFSMFGLQFFGDRAR 130
Cdd:COG0500   93 ESFDLVVAFGVLHHLPPEER 112
PRK08317 PRK08317
hypothetical protein; Provisional
 50-134 3.36e-10

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 58.79  E-value: 3.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177240  50 VLDVACGSGAVAL---LAASAAERVEALDFSVQMLDRLREQATRQGStNVCVREGNGQALPFPDESFDVAFSMFGLQFFG 126
Cdd:PRK08317  23 VLDVGCGPGNDARelaRRVGPEGRVVGIDRSEAMLALAKERAAGLGP-NVEFVRGDADGLPFPDGSFDAVRSDRVLQHLE 101


                 ....*...
gi 260177240 127 DRARGLAE 134
Cdd:PRK08317 102 DPARALAE 109
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 41-134 2.63e-09

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 56.30  E-value: 2.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177240  41 LASLPAR--AHVLDVACGSGAVALLAASAAERVEALDFSVQMLDRLREQATRQGSTnvcvrEGNGQALPFPDESFDVAFS 118
Cdd:PRK10258  35 LAMLPQRkfTHVLDAGCGPGWMSRYWRERGSQVTALDLSPPMLAQARQKDAADHYL-----AGDIESLPLATATFDLAWS 109

                         90
                 ....*....|....*.
gi 260177240 119 MFGLQFFGDRARGLAE 134
Cdd:PRK10258 110 NLAVQWCGNLSTALRE 125
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
48-133 7.56e-08

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 49.44  E-value: 7.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177240  48 AHVLDVACGSGAVALL--AASAAERVEALDFSVQMLDRLREQATrqgstNVCVREGNGQALPfPDESFDVAFSMFGLQFF 125
Cdd:COG4106    3 RRVLDLGCGTGRLTALlaERFPGARVTGVDLSPEMLARARARLP-----NVRFVVADLRDLD-PPEPFDLVVSNAALHWL 76


                 ....*...
gi 260177240 126 GDRARGLA 133
Cdd:COG4106   77 PDHAALLA 84
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
32-134 9.52e-08

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 50.77  E-value: 9.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177240  32 RHFAMEAIRLASLPARAHVLDVACGSGAVALLAASAAERVEALDFSVQMLDRLREqatRQGSTNvcVREGNGQALPFPDE 111
Cdd:COG4976   32 ALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKARE---KGVYDR--LLVADLADLAEPDG 106

                         90       100
                 ....*....|....*....|...
gi 260177240 112 SFDVAFSMFGLQFFGDRARGLAE 134
Cdd:COG4976  107 RFDLIVAADVLTYLGDLAAVFAG 129
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 38-134 2.38e-07

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 50.36  E-value: 2.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177240   38 AIRLASL------PARAHVLDVACGSGAVALLAASAAERVE--ALDFSVQMLdrlrEQATRQGSTNVCVREGNGQALPFP 109
Cdd:TIGR02072  20 AKRLLALlkekgiFIPASVLDIGCGTGYLTRALLKRFPQAEfiALDISAGML----AQAKTKLSENVQFICGDAEKLPLE 95

                          90       100
                  ....*....|....*....|....*
gi 260177240  110 DESFDVAFSMFGLQFFGDRARGLAE 134
Cdd:TIGR02072  96 DSSFDLIVSNLALQWCDDLSQALSE 120
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 27-130 1.06e-05

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 44.54  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177240  27 MDPHTRHFAMEAIRLASLPARAHVLDVACGSGAVALLAASAAE-RVEALDFSVQMLDRLREQATRQGSTNVC-VREGNGQ 104
Cdd:COG2230   32 LEEAQEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYGvRVTGVTLSPEQLEYARERAAEAGLADRVeVRLADYR 111

                         90       100
                 ....*....|....*....|....*.
gi 260177240 105 ALPfPDESFDVAFSMFGLQFFGDRAR 130
Cdd:COG2230  112 DLP-ADGQFDAIVSIGMFEHVGPENY 136
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 50-134 1.21e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 43.19  E-value: 1.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177240  50 VLDVACGSGAVALL-AASAAERVEALDFSVQMLDRLREQATRQGSTNVCVREGNG-QALPFPDESFDVAFSMFGLQFFGD 127
Cdd:cd02440    2 VLDLGCGTGALALAlASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAeELPPEADESFDVIISDPPLHHLVE 81


                 ....*..
gi 260177240 128 RARGLAE 134
Cdd:cd02440   82 DLARFLE 88
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 49-118 1.64e-05

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 43.94  E-value: 1.64e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 260177240   49 HVLDVACGSGA---VALLAASAAERVEALDFSVQMLDRLREQATRQGSTNVCVREGNGQALP--FPDESFDVAFS 118
Cdd:pfam13847   6 RVLDLGCGTGHlsfELAEELGPNAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPelLEDDKFDVVIS 80
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 51-139 7.07e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 40.81  E-value: 7.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177240   51 LDVACGSGAVALLAASAAERVE--ALDFSVQMLDRLREQ-ATRQGSTNVCVREGNGQALPFPDESFDVAFSMFGLQFFGD 127
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEytGLDISPAALEAARERlAALGLLNAVRVELFQLDLGELDPGSFDVVVASNVLHHLAD 80

                          90
                  ....*....|..
gi 260177240  128 RARGLAELRRVL 139
Cdd:pfam08242  81 PRAVLRNIRRLL 92
arsM PRK11873
arsenite methyltransferase;
70-134 8.65e-05

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 43.01  E-value: 8.65e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 260177240  70 RVEALDFSVQMLDRLREQATRQGSTNVCVREGNGQALPFPDESFDVAFSMFGLQFFGDRARGLAE 134
Cdd:PRK11873 104 KVIGVDMTPEMLAKARANARKAGYTNVEFRLGEIEALPVADNSVDVIISNCVINLSPDKERVFKE 168
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 50-134 4.79e-04

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 40.64  E-value: 4.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177240  50 VLDVACGSGAVA---LLAASAAERVEALDFSVQMLDRL-REQATRQGSTNVCVR--EGNGQALPFPDESFDVAFSMFGLQ 123
Cdd:PLN02233  77 VLDLCCGSGDLAfllSEKVGSDGKVMGLDFSSEQLAVAaSRQELKAKSCYKNIEwiEGDATDLPFDDCYFDAITMGYGLR 156

                         90
                 ....*....|.
gi 260177240 124 FFGDRARGLAE 134
Cdd:PLN02233 157 NVVDRLKAMQE 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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