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Conserved domains on  [gi|260764824|gb|ACX49502|]
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beta-carotene hydroxylase 1 [Zea mays]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FA_hydroxylase super family cl01132
Fatty acid hydroxylase; This entry includes fatty acid and carotene hydroxylases and sterol ...
 74-274 3.48e-137

Fatty acid hydroxylase; This entry includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif which coordinate two irons at the catalytic centre. Members of this family are ER integral membrane proteins that share a novel mushroom-shaped fold consisting of four transmembrane (TM1-TM4) helices that anchor them to the membrane capped by a cytosolic domain containing the unique histidine- coordinating di metal centre.


The actual alignment was detected with superfamily member PLN02601:

Pssm-ID: 412761  Cd Length: 303  Bit Score: 390.59  E-value: 3.48e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260764824  74 KEARKRSERRTYLVAAVMSSLGVTSMAVAAVYYRFSWQMEGGEVPVIETLGTFALSVGAAVGMEFWARWAHRALWHASLW 153
Cdd:PLN02601  85 KAEKKKSERFTYLIAAVMSSFGITSMAIMAVYYRFSWQMKGGEVSMLEMFGTFALSVGAAVGMEFWARWAHRALWHDSLW 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260764824 154 HMHESHHRPREGPFELNDVFAIVNAAPAISLLAYGFFHRGIVPGLCFGAGLGITLFGMAYMFVHDGLVHRRFPVGPIADV 233
Cdd:PLN02601 165 NMHESHHKPREGAFELNDVFAIVNAVPAIGLLYYGFFNKGLVPGLCFGAGLGITVFGMAYMFVHDGLVHKRFPVGPIANV 244

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 260764824 234 PYFRR******IHHMDKFGGVPYGLFLGPKELEEVGGLDEL 274
Cdd:PLN02601 245 PYLRKVAAAHQLHHTDKFKGVPYGLFLGPKEVEEVGGKEEL 285
 
Name Accession Description Interval E-value
PLN02601 PLN02601
beta-carotene hydroxylase
 74-274 3.48e-137

beta-carotene hydroxylase


Pssm-ID: 178211  Cd Length: 303  Bit Score: 390.59  E-value: 3.48e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260764824  74 KEARKRSERRTYLVAAVMSSLGVTSMAVAAVYYRFSWQMEGGEVPVIETLGTFALSVGAAVGMEFWARWAHRALWHASLW 153
Cdd:PLN02601  85 KAEKKKSERFTYLIAAVMSSFGITSMAIMAVYYRFSWQMKGGEVSMLEMFGTFALSVGAAVGMEFWARWAHRALWHDSLW 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260764824 154 HMHESHHRPREGPFELNDVFAIVNAAPAISLLAYGFFHRGIVPGLCFGAGLGITLFGMAYMFVHDGLVHRRFPVGPIADV 233
Cdd:PLN02601 165 NMHESHHKPREGAFELNDVFAIVNAVPAIGLLYYGFFNKGLVPGLCFGAGLGITVFGMAYMFVHDGLVHKRFPVGPIANV 244

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 260764824 234 PYFRR******IHHMDKFGGVPYGLFLGPKELEEVGGLDEL 274
Cdd:PLN02601 245 PYLRKVAAAHQLHHTDKFKGVPYGLFLGPKEVEEVGGKEEL 285
FA_hydroxylase pfam04116
Fatty acid hydroxylase; This entry includes fatty acid and carotene hydroxylases and sterol ...
 130-261 3.53e-10

Fatty acid hydroxylase; This entry includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif which coordinate two irons at the catalytic centre. Members of this family are ER integral membrane proteins that share a novel mushroom-shaped fold consisting of four transmembrane (TM1-TM4) helices that anchor them to the membrane capped by a cytosolic domain containing the unique histidine- coordinating di metal centre.


Pssm-ID: 397991  Cd Length: 134  Bit Score: 57.05  E-value: 3.53e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260764824  130 VGAAVGMEFWARWAHRAL-WHASLW-HMHESHHRPREGPFELNDVFAIVNAAPAISLLAYGFFhrgIVPGLCFGAGLGIT 207
Cdd:pfam04116   2 LLGLLLFDFLFYWVHRLLhRLPWLWrRFHKVHHSSEAPNALTALRFHPLEALLFALLVLLPLL---LLGLPLLAFLLGLL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 260764824  208 LFGMAYMFVHDGLVHRRFPVGpiadvPYFRR******IHHMdKFGGVPYGLFLG 261
Cdd:pfam04116  79 LGTLWYLFIHSGLLFPLPWLL-----KRLLGTPRFHRLHHS-KNEEYNFGVTFP 126
 
Name Accession Description Interval E-value
PLN02601 PLN02601
beta-carotene hydroxylase
 74-274 3.48e-137

beta-carotene hydroxylase


Pssm-ID: 178211  Cd Length: 303  Bit Score: 390.59  E-value: 3.48e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260764824  74 KEARKRSERRTYLVAAVMSSLGVTSMAVAAVYYRFSWQMEGGEVPVIETLGTFALSVGAAVGMEFWARWAHRALWHASLW 153
Cdd:PLN02601  85 KAEKKKSERFTYLIAAVMSSFGITSMAIMAVYYRFSWQMKGGEVSMLEMFGTFALSVGAAVGMEFWARWAHRALWHDSLW 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260764824 154 HMHESHHRPREGPFELNDVFAIVNAAPAISLLAYGFFHRGIVPGLCFGAGLGITLFGMAYMFVHDGLVHRRFPVGPIADV 233
Cdd:PLN02601 165 NMHESHHKPREGAFELNDVFAIVNAVPAIGLLYYGFFNKGLVPGLCFGAGLGITVFGMAYMFVHDGLVHKRFPVGPIANV 244

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 260764824 234 PYFRR******IHHMDKFGGVPYGLFLGPKELEEVGGLDEL 274
Cdd:PLN02601 245 PYLRKVAAAHQLHHTDKFKGVPYGLFLGPKEVEEVGGKEEL 285
FA_hydroxylase pfam04116
Fatty acid hydroxylase; This entry includes fatty acid and carotene hydroxylases and sterol ...
 130-261 3.53e-10

Fatty acid hydroxylase; This entry includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif which coordinate two irons at the catalytic centre. Members of this family are ER integral membrane proteins that share a novel mushroom-shaped fold consisting of four transmembrane (TM1-TM4) helices that anchor them to the membrane capped by a cytosolic domain containing the unique histidine- coordinating di metal centre.


Pssm-ID: 397991  Cd Length: 134  Bit Score: 57.05  E-value: 3.53e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260764824  130 VGAAVGMEFWARWAHRAL-WHASLW-HMHESHHRPREGPFELNDVFAIVNAAPAISLLAYGFFhrgIVPGLCFGAGLGIT 207
Cdd:pfam04116   2 LLGLLLFDFLFYWVHRLLhRLPWLWrRFHKVHHSSEAPNALTALRFHPLEALLFALLVLLPLL---LLGLPLLAFLLGLL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 260764824  208 LFGMAYMFVHDGLVHRRFPVGpiadvPYFRR******IHHMdKFGGVPYGLFLG 261
Cdd:pfam04116  79 LGTLWYLFIHSGLLFPLPWLL-----KRLLGTPRFHRLHHS-KNEEYNFGVTFP 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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