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Conserved domains on  [gi|283825358|gb|ADB43129|]
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conotoxin Cal 5.2 precursor [Californiconus californicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Chi-conotoxin super family cl25240
chi-Conotoxin or t superfamily; Chi-conotoxin is a family of Cone snail venom chi-conopeptide ...
 2-63 5.46e-07

chi-Conotoxin or t superfamily; Chi-conotoxin is a family of Cone snail venom chi-conopeptide class bioactive peptides based. These conopeptides show a unique ability, highly selectively and non-competitively, to inhibit the noradrenaline transporter. They show an unusual cysteine-stabilized scaffold that presents a gamma-turn in an optimized conformation for high affinity interactions with the noradrenaline transporter.


The actual alignment was detected with superfamily member pfam16981:

Pssm-ID: 293586  Cd Length: 60  Bit Score: 41.43  E-value: 5.46e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 283825358   2 MYCLPVVCILLLLIPSSATFVVESRLEKDQAQ-SFTGDAwKRVSPIHEMiqRSQCCAVKKNCC 63
Cdd:pfam16981  1 MRCLPVFVILLLLIASAPSVDAQPKTKDDVPLaSFHDNA-KRTLQRLWN--KRSCCPIDLSCC 60
 
Name Accession Description Interval E-value
Chi-conotoxin pfam16981
chi-Conotoxin or t superfamily; Chi-conotoxin is a family of Cone snail venom chi-conopeptide ...
 2-63 5.46e-07

chi-Conotoxin or t superfamily; Chi-conotoxin is a family of Cone snail venom chi-conopeptide class bioactive peptides based. These conopeptides show a unique ability, highly selectively and non-competitively, to inhibit the noradrenaline transporter. They show an unusual cysteine-stabilized scaffold that presents a gamma-turn in an optimized conformation for high affinity interactions with the noradrenaline transporter.


Pssm-ID: 293586  Cd Length: 60  Bit Score: 41.43  E-value: 5.46e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 283825358   2 MYCLPVVCILLLLIPSSATFVVESRLEKDQAQ-SFTGDAwKRVSPIHEMiqRSQCCAVKKNCC 63
Cdd:pfam16981  1 MRCLPVFVILLLLIASAPSVDAQPKTKDDVPLaSFHDNA-KRTLQRLWN--KRSCCPIDLSCC 60
 
Name Accession Description Interval E-value
Chi-conotoxin pfam16981
chi-Conotoxin or t superfamily; Chi-conotoxin is a family of Cone snail venom chi-conopeptide ...
 2-63 5.46e-07

chi-Conotoxin or t superfamily; Chi-conotoxin is a family of Cone snail venom chi-conopeptide class bioactive peptides based. These conopeptides show a unique ability, highly selectively and non-competitively, to inhibit the noradrenaline transporter. They show an unusual cysteine-stabilized scaffold that presents a gamma-turn in an optimized conformation for high affinity interactions with the noradrenaline transporter.


Pssm-ID: 293586  Cd Length: 60  Bit Score: 41.43  E-value: 5.46e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 283825358   2 MYCLPVVCILLLLIPSSATFVVESRLEKDQAQ-SFTGDAwKRVSPIHEMiqRSQCCAVKKNCC 63
Cdd:pfam16981  1 MRCLPVFVILLLLIASAPSVDAQPKTKDDVPLaSFHDNA-KRTLQRLWN--KRSCCPIDLSCC 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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