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Conserved domains on  [gi|300487159|gb|ADK21606|]
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NADH dehydrogenase subunit 4, partial (mitochondrion) [Chodsigoa sodalis]

Protein Classification

proton-conducting transporter membrane subunit( domain architecture ID 1562513)

proton-conducting transporter membrane subunit such as NADH dehydrogenase subunit 2, 4, or N, which shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain

EC:  7.1.-.-
Gene Ontology:  GO:0005886

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Proton_antipo_M super family cl39059
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
1-209 1.28e-132

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


The actual alignment was detected with superfamily member MTH00110:

Pssm-ID: 476862 [Multi-domain]  Cd Length: 459  Bit Score: 380.01  E-value: 1.28e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159   1 NPITETMAYPFLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLA 80
Cdd:MTH00110 251 NPLTEFMAYPFLMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAILIQTPWSFMGATALMIAHGLTSSMLFCLA 330
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  81 NTNYERIHSRTMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGTNVVITALYSLYM 160
Cdd:MTH00110 331 NSNYERIHSRTMILARGLQTLLPLMATWWLLASLTNLALPPTINLIGELFVIMSSFSWSNITIILMGLNMLITALYSLYM 410
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 300487159 161 LITTQRGKYSYHVNTIKPTFTRENSLMALHMIPLLLLSINPKLILGTLY 209
Cdd:MTH00110 411 LITTQRGKLTHHINNIKPSFTRENTLMALHLLPLLLLSLNPKIILGPTY 459
 
Name Accession Description Interval E-value
ND4 MTH00110
NADH dehydrogenase subunit 4; Provisional
1-209 1.28e-132

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177172 [Multi-domain]  Cd Length: 459  Bit Score: 380.01  E-value: 1.28e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159   1 NPITETMAYPFLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLA 80
Cdd:MTH00110 251 NPLTEFMAYPFLMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAILIQTPWSFMGATALMIAHGLTSSMLFCLA 330
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  81 NTNYERIHSRTMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGTNVVITALYSLYM 160
Cdd:MTH00110 331 NSNYERIHSRTMILARGLQTLLPLMATWWLLASLTNLALPPTINLIGELFVIMSSFSWSNITIILMGLNMLITALYSLYM 410
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 300487159 161 LITTQRGKYSYHVNTIKPTFTRENSLMALHMIPLLLLSINPKLILGTLY 209
Cdd:MTH00110 411 LITTQRGKLTHHINNIKPSFTRENTLMALHLLPLLLLSLNPKIILGPTY 459
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
4-208 7.79e-38

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 136.36  E-value: 7.79e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159   4 TETMAYPFLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTN 83
Cdd:COG1008  271 SAYFAPLLAALGVIGIIYGALVALAQTDLKRLIAYSSVSHMGFVLLGIFALNPLGLQGAVLQMVSHGLITAALFLLVGVL 350
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  84 YERIHSRTMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGTNVVITALYSLYMLit 163
Cdd:COG1008  351 YDRTHTRDIADLGGLAKRMPVLAALFLLAALASLGLPGTSGFVGEFLVLLGAFQVNPWLAILAALGLILTAAYLLWMY-- 428
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 300487159 164 tQR---GKYSYHVNTIKPTFTRENSLMALHMIPLLLLSINPKLILGTL 208
Cdd:COG1008  429 -QRvffGPLKEELAELPDLNPRELAVLAPLAALILLLGLYPQPLLDLI 475
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
7-209 4.34e-33

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 123.51  E-value: 4.34e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159    7 MAYPFLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTNYER 86
Cdd:TIGR01972 268 FAPVLAALGVIAIIYGALIALAQTDIKRLIAYSSISHMGFVLLGIFSFNELGISGAVFQMISHGLITAALFLLVGVLYER 347
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159   87 IHSRTMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGTNVVITALYSLYMLITTQR 166
Cdd:TIGR01972 348 AHTRDIAKYGGLANKMPVLAAFFMLFAMASLGLPGTSGFVGEFLILLGSFKVNPVVAFLAALGIVLAAAYMLTLYKRVFF 427
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 300487159  167 GKYS-YHVNTIKPTFTRENSLMALHMIPLLLLSINPKLILGTLY 209
Cdd:TIGR01972 428 GELSnPEVAEFPDLNGREIAVLAPLVVLILFLGLYPNPLLDLTE 471
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
2-148 4.25e-31

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 114.72  E-value: 4.25e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159    2 PITETMAYPFLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLA- 80
Cdd:pfam00361 141 PSSPFIQQILLILAIISMLLGSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFHLLTHGLFSAGLFLCAg 220
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300487159   81 NTNYERIHSRTMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGT 148
Cdd:pfam00361 221 SVIYRRVHTRNIRDYGGLAKTMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGV 288
 
Name Accession Description Interval E-value
ND4 MTH00110
NADH dehydrogenase subunit 4; Provisional
1-209 1.28e-132

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177172 [Multi-domain]  Cd Length: 459  Bit Score: 380.01  E-value: 1.28e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159   1 NPITETMAYPFLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLA 80
Cdd:MTH00110 251 NPLTEFMAYPFLMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAILIQTPWSFMGATALMIAHGLTSSMLFCLA 330
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  81 NTNYERIHSRTMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGTNVVITALYSLYM 160
Cdd:MTH00110 331 NSNYERIHSRTMILARGLQTLLPLMATWWLLASLTNLALPPTINLIGELFVIMSSFSWSNITIILMGLNMLITALYSLYM 410
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 300487159 161 LITTQRGKYSYHVNTIKPTFTRENSLMALHMIPLLLLSINPKLILGTLY 209
Cdd:MTH00110 411 LITTQRGKLTHHINNIKPSFTRENTLMALHLLPLLLLSLNPKIILGPTY 459
ND4 MTH00124
NADH dehydrogenase subunit 4; Provisional
1-207 3.52e-103

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214427 [Multi-domain]  Cd Length: 457  Bit Score: 305.20  E-value: 3.52e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159   1 NPITETMAYPFLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLA 80
Cdd:MTH00124 251 PPLSNTLHYPFLTLALWGALMTSLICLRQTDLKSLIAYSSVSHMGLVIAATMIQTPWSLSGAMILMIAHGLTSSMLFCLA 330
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  81 NTNYERIHSRTMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGTNVVITALYSLYM 160
Cdd:MTH00124 331 NTNYERTHSRTLLLTRGLQLLLPLMTTWWLLANLTNMALPPTINLMGELTIMTSLFNWSPTTIILTGLATLITASYTLYM 410
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 300487159 161 LITTQRGKYSYHVNTIKPTFTRENSLMALHMIPLLLLSINPKLILGT 207
Cdd:MTH00124 411 FLSTQRGTLPTHITTIQPTHTREHLLMTLHIIPLLLLILKPELISGT 457
ND4 MTH00068
NADH dehydrogenase subunit 4; Provisional
1-208 5.48e-97

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214417 [Multi-domain]  Cd Length: 458  Bit Score: 289.51  E-value: 5.48e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159   1 NPITETMAYPFLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLA 80
Cdd:MTH00068 251 TPLSKELSYPFIILALWGVLMTSLICLRQTDLKSLIAYSSVSHMGLVIAAALIQTPWSFSGAIILMISHGLTSSALFCLA 330
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  81 NTNYERIHSRTMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGTNVVITALYSLYM 160
Cdd:MTH00068 331 NTNYERTHSRTLLLLRGAQTILPLMATWWLLSNLSNMALPPSPNLWGELTIMVSLFNWSNWTILITGLGTLITAAYTLYM 410
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 300487159 161 LITTQRGKYSYHVNTIKPTFTRENSLMALHMIPLLLLSINPKLILGTL 208
Cdd:MTH00068 411 FLMTQRGPLPNHLKTLFPTYTREHLLLALHILPMLLLILKPELISGMF 458
ND4 MTH00127
NADH dehydrogenase subunit 4; Provisional
1-206 4.95e-78

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177186 [Multi-domain]  Cd Length: 459  Bit Score: 241.01  E-value: 4.95e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159   1 NPITETMAYPFLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLA 80
Cdd:MTH00127 252 DPLTKELSYPFIILALWGIIMTGSICLRQTDLKSLIAYSSVSHMGLVAGGILIQTPWGFTGALILMIAHGLTSSALFCLA 331
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  81 NTNYERIHSRTMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGTNVVITALYSLYM 160
Cdd:MTH00127 332 NTNYERTHSRTMLLARGLQMILPLMATWWFIASLANLALPPLPNLMGELMIITSLFNWSPWTLALTGLGTLITAGYSLYM 411
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 300487159 161 LITTQRGKYSYHVNTIKPTFTRENSLMALHMIPLLLLSINPKLILG 206
Cdd:MTH00127 412 FLMTQRGPLPDHIIALNPSHTREHLLMALHLLPLLLLILKPELIWG 457
ND4 MTH00206
NADH dehydrogenase subunit 4; Provisional
1-204 2.85e-74

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214458 [Multi-domain]  Cd Length: 450  Bit Score: 230.98  E-value: 2.85e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159   1 NPITETMAYPFLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLA 80
Cdd:MTH00206 247 GPSTKLSSYFFIILGLWGSIMTSSICLRQTDLKSLIAYSSVSHMSLVTAGILSGSPWGFKGALLLMIAHGLVSSALFCLA 326
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  81 NTNYERIHSRTMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGTNVVITALYSLYM 160
Cdd:MTH00206 327 NLLYERSHTRTILGNRGLQMILPLLSFWWLLFFLANLGLPPFPNLFGELLIITSLFSWSNFTLPLLGLGFLFTAIYSLYM 406
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 300487159 161 LITTQRGKYSYHVNTIKPTFTRENSLMALHMIPLLLLSINPKLI 204
Cdd:MTH00206 407 FVMTQHGKTPNHLLSLSPSSTREHLLLFLHLFPVILLILNPNLI 450
ND4 MTH00044
NADH dehydrogenase subunit 4; Validated
2-205 2.06e-59

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214411 [Multi-domain]  Cd Length: 458  Bit Score: 192.88  E-value: 2.06e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159   2 PITETMAYPFLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLAN 81
Cdd:MTH00044 254 PSANNISFILIVFCCWGALITSIICLRQTDLKALIAYSSVGHMSLVAAGIFSGTNWGINGALILMIAHGLVSSALFCLAN 333
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  82 TNYERIHSRTMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGTNVVITALYSLYML 161
Cdd:MTH00044 334 ILYERSGTRTLSITRGFKLITPLLPLWWLIFCAANLGLPPLPNLIGELLIISSIISWSILSFPIIGLATVFGAIYSLLIY 413
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 300487159 162 ITTQRGKYSYHVNTIKPTFTRENSLMALHMIPLLLLSINPKLIL 205
Cdd:MTH00044 414 QLTNSGSFPSWISNVSPISSREHLLIFLHLLPLILIIINPNIIL 457
ND4 MTH00163
NADH dehydrogenase subunit 4; Provisional
9-205 5.70e-54

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214443 [Multi-domain]  Cd Length: 445  Bit Score: 178.04  E-value: 5.70e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159   9 YPFLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTNYERIH 88
Cdd:MTH00163 247 YIWISISLVGGVIVSLICLRQVDLKSLIAYSSVAHMGLVLGGLMTFSYWGLMGSLLMMIGHGLCSSGLFCLANIIYERLG 326
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  89 SRTMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGTNVVITALYSLYMLITTQRGK 168
Cdd:MTH00163 327 SRSLLINKGLLNFMPSMSLWWFLLSSSNMAAPPSLNLLGEISLINSLISWSKLSMIFLMLLSFFSAAYSLYLYSYSQHGK 406
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 300487159 169 YSYHVNTIKPTFTRENSLMALHMIPLLLLSINPKLIL 205
Cdd:MTH00163 407 YYSGLYSCSSGKVREYLLLFLHWLPLNLLILKSDLFM 443
ND4 MTH00150
NADH dehydrogenase subunit 4; Provisional
14-204 1.22e-51

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214435 [Multi-domain]  Cd Length: 417  Bit Score: 171.56  E-value: 1.22e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  14 LSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTNYERIHSRTMI 93
Cdd:MTH00150 223 LSLWGGVLTSLICLRQSDVKSLIAYSSVGHMSLVLAGVLSNTSWGWVGALIMMVSHGFCSSGLFCLANYTYEKVHSRSLF 302
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  94 LARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFI---MLTSFYWSNITMLLMgtnVVITALYSLYMLITTQRGKYS 170
Cdd:MTH00150 303 LSKGMLMLYPSLSLWWFLFCIINMAAPPSLNLLSEIMIfpsLISYSPWFFVPLGLM---VFLSGLYSLYLYTSIQHGGSS 379
                        170       180       190
                 ....*....|....*....|....*....|....
gi 300487159 171 YHVNTIKPTFTRENSLMALHMIPLLLLSINPKLI 204
Cdd:MTH00150 380 SFLKPFNELKSSEMLLLLLHWVPLLLLILKSDLL 413
ND4 MTH00205
NADH dehydrogenase subunit 4; Provisional
11-204 1.07e-44

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214457 [Multi-domain]  Cd Length: 448  Bit Score: 153.98  E-value: 1.07e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  11 FLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTNYERIHSR 90
Cdd:MTH00205 253 FFSISLWGGVMTGMICLRQVDLKSLIAYSSVGHMGLMVVGVFSNTSWGMNGAIIMMVAHGLCSSGMFALANVNYERTNSR 332
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  91 TMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGTNVVITALYSLYMLITTQRGKYS 170
Cdd:MTH00205 333 SMLMNKGVLNTFPFLVLMWFLLISCNMAAPPSLNLASEILLIMSLLSSSKISGIPLSLISFLSGAYSLYLYSQSQHGKVS 412
                        170       180       190
                 ....*....|....*....|....*....|....
gi 300487159 171 YHVNTIKPTFTRENSLMALHMIPLLLLSINPKLI 204
Cdd:MTH00205 413 SQISSFLAISEREYYILILHWFPLNILILKLKIF 446
ND4 MTH00014
NADH dehydrogenase subunit 4; Validated
3-204 2.73e-41

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214399 [Multi-domain]  Cd Length: 452  Bit Score: 145.27  E-value: 2.73e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159   3 ITETMAYPFLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANT 82
Cdd:MTH00014 247 INKSLSAPFSSISLVGAVITSLICIRQPDLKSLIAYSSVGHMGLMTAGIMSNTSWGWQGALAMMIAHGLCSSALFALANM 326
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  83 NYERIHSRTMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGTNVVITALYSLYMLI 162
Cdd:MTH00014 327 TYETTHTRSLFLTKGLLSLFPTMTMWWFLLSAANMAAPPSINLLSEIMLLTSILSSSLSTAILLAITSFLAAAYSLFLYT 406
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 300487159 163 TTQRGKYSYHVNTIKPTFTRENSLMALHMIPLLLLSINPKLI 204
Cdd:MTH00014 407 STQHGSPPSFMNPLNLFTPRNHTLMTLHLVPLFILILKPDLI 448
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
4-208 7.79e-38

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 136.36  E-value: 7.79e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159   4 TETMAYPFLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTN 83
Cdd:COG1008  271 SAYFAPLLAALGVIGIIYGALVALAQTDLKRLIAYSSVSHMGFVLLGIFALNPLGLQGAVLQMVSHGLITAALFLLVGVL 350
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  84 YERIHSRTMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGTNVVITALYSLYMLit 163
Cdd:COG1008  351 YDRTHTRDIADLGGLAKRMPVLAALFLLAALASLGLPGTSGFVGEFLVLLGAFQVNPWLAILAALGLILTAAYLLWMY-- 428
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 300487159 164 tQR---GKYSYHVNTIKPTFTRENSLMALHMIPLLLLSINPKLILGTL 208
Cdd:COG1008  429 -QRvffGPLKEELAELPDLNPRELAVLAPLAALILLLGLYPQPLLDLI 475
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
7-209 4.34e-33

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 123.51  E-value: 4.34e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159    7 MAYPFLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTNYER 86
Cdd:TIGR01972 268 FAPVLAALGVIAIIYGALIALAQTDIKRLIAYSSISHMGFVLLGIFSFNELGISGAVFQMISHGLITAALFLLVGVLYER 347
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159   87 IHSRTMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGTNVVITALYSLYMLITTQR 166
Cdd:TIGR01972 348 AHTRDIAKYGGLANKMPVLAAFFMLFAMASLGLPGTSGFVGEFLILLGSFKVNPVVAFLAALGIVLAAAYMLTLYKRVFF 427
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 300487159  167 GKYS-YHVNTIKPTFTRENSLMALHMIPLLLLSINPKLILGTLY 209
Cdd:TIGR01972 428 GELSnPEVAEFPDLNGREIAVLAPLVVLILFLGLYPNPLLDLTE 471
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
2-148 4.25e-31

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 114.72  E-value: 4.25e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159    2 PITETMAYPFLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLA- 80
Cdd:pfam00361 141 PSSPFIQQILLILAIISMLLGSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFHLLTHGLFSAGLFLCAg 220
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300487159   81 NTNYERIHSRTMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGT 148
Cdd:pfam00361 221 SVIYRRVHTRNIRDYGGLAKTMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGV 288
PRK05846 PRK05846
NADH:ubiquinone oxidoreductase subunit M; Reviewed
7-208 4.69e-31

NADH:ubiquinone oxidoreductase subunit M; Reviewed


Pssm-ID: 235622 [Multi-domain]  Cd Length: 497  Bit Score: 118.00  E-value: 4.69e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159   7 MAYPFLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTNYER 86
Cdd:PRK05846 276 FAPIIITLGVIAIIYGALVALAQTDIKKLIAYSSISHMGFVTLGIFAGNQLGIQGAIFQMISHGLSSAALFLLVGVLYDR 355
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  87 IHSRTMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGTNVVITALYSLYMLITTQR 166
Cdd:PRK05846 356 LHTRDIADYGGLAKVMPVLAAFFLFFAMASLGLPGTSGFVGEFLILLGSFQVNPVIAFIATTGLILAAVYSLWLYQRVMF 435
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 300487159 167 GKYSYHVNTIKPTFTRENSLMALHMIPLLLLSINPKLILGTL 208
Cdd:PRK05846 436 GPVKNEVAKLKDLNGRELLILLPLVALLLLLGVYPKPLLDVI 477
ND4 MTH00217
NADH dehydrogenase subunit 4; Provisional
10-160 5.04e-27

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214462 [Multi-domain]  Cd Length: 482  Bit Score: 107.06  E-value: 5.04e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  10 PFLL-LSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTNYERIH 88
Cdd:MTH00217 273 PLIQtLSLLAIIYGSLTTCRQVDLKRIIAYSSVAHMGLVTLGIFSHTIQGLVAAIFLMLAHGLVSSALFIAVTFLYERHH 352
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300487159  89 SRTMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGTNVVITALYSLYM 160
Cdd:MTH00217 353 TRLIKYYRGMVITMPLFGILMLLLVLANASIPLSCNFVGEFLSLLAAFEYSYIVGVLASLGMVLSAGYSIYL 424
ND4 MTH00204
NADH dehydrogenase subunit 4; Provisional
12-208 2.16e-26

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 164750 [Multi-domain]  Cd Length: 485  Bit Score: 105.15  E-value: 2.16e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  12 LLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTNYERIHSRT 91
Cdd:MTH00204 279 VMLSVIAVIYGSLTTCRQVDFKRLIAYSSVAHMGLVPLGLFTHTIEGLVAAVFLMLAHGFVSSALFIAVTFLYERHHTRL 358
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  92 MILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGTNVVITALYSLYMLITTQRGKYSY 171
Cdd:MTH00204 359 IKYYRGLTLTMPLFVIIMLVLSLANMGFPLSCNFVGEFFSLLAAFEYSLGLGVLVTSGMVWSAAYSLYLYNRISFGGGSN 438
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 300487159 172 HVNTIKPTFTRENSLMALHMIPLLLLSINPKLILGTL 208
Cdd:MTH00204 439 YLLFSRDLNRRELLAILPLIIAIFLLGIVPFIIIDLV 475
ND4 MTH00226
NADH dehydrogenase subunit 4; Provisional
5-205 2.88e-24

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214466 [Multi-domain]  Cd Length: 505  Bit Score: 99.23  E-value: 2.88e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159   5 ETMAYPFLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTNY 84
Cdd:MTH00226 293 QNLAPAVIAMGIVGIVYGSFATCRQIDVKRLVAYSSVAHMGLVSITLVTHDIIGLTGSIFIMLAHGIVSSLLFILVTILY 372
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  85 ERIHSRTMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGTNVVITALYSLYMLITT 164
Cdd:MTH00226 373 DRHHTRLIKYYRGLSITMPIWGTIMIVTSLANVAVPPSGNFIGEYLSILSSFNWNPIIGVFVCSGVILSAVYSFYFANRV 452
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 300487159 165 QRGKYSYHVNTIKPTFTRENSLMALHMIPLLLLSINPKLIL 205
Cdd:MTH00226 453 TFGAPGNLITFARDVNRREFYITASMVFFAFLIGIYPIFIL 493
ND4 MTH00094
NADH dehydrogenase subunit 4; Provisional
11-177 2.30e-17

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177157 [Multi-domain]  Cd Length: 403  Bit Score: 79.18  E-value: 2.30e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  11 FLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTNYERIHSR 90
Cdd:MTH00094 216 WIIFSLLGMILSSFCCVFQSDSKSLAAYSSVTHMSFLLLSLVYMSMSGKLSGLMMMLAHGYTSTLMFYLIGEFYHISKSR 295
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  91 TMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGTNVVITALYSLYMLITTQRGKYS 170
Cdd:MTH00094 296 LIYFMNSFFSSSMFFGLIFSLVFLSNSGVPPSLSFFSEFLIISNSFMKNKFSFFFIFFYFLVSFYYSLFLIVSSFMGKKF 375

                 ....*..
gi 300487159 171 YHVNTIK 177
Cdd:MTH00094 376 SNFNNFN 382
PRK12561 PRK12561
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
29-161 2.94e-17

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 237137 [Multi-domain]  Cd Length: 504  Bit Score: 79.31  E-value: 2.94e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  29 QTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTNYERIHSRTMILARGLQTILPLMSAW 108
Cdd:PRK12561 272 QDNVKRRLAYSSVSHMGFVLLGIAAFTDLGISGAMLQMISHGLIAAALFFLTGVTYERTHTLSIPNMGGLAKVMPKTFAL 351
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159 109 WLLASLTNLALPPTINLIGEL--FIMLTS--FYWSN---ITMLLMGTNVVITALYSLYML 161
Cdd:PRK12561 352 FTASSMASLALPGMSGFVSELtvFLGITSsdVYSSTfrtITILLAAVGLILTPIYLLSML 411
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
2-165 3.10e-15

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 73.26  E-value: 3.10e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159   2 PITETMAYPFLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLAN 81
Cdd:COG0651  266 DPALFLGTLLLVLGLLTMLVGALGALAQRDLKRLLAYSSVSQIGYILLGLGLGTPLGLAGALFHLLNHALAKALLFLAAG 345
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  82 TNYERIHSRTMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSF----YWSNITMLLMGtnvVITALYS 157
Cdd:COG0651  346 AIERATGTRDLDKLGGLGKRMPLTAAAFLIGALALAGLPPLSGFVSKWLLLQAALeagaWLLAAVLLLSS---LLTLAYF 422

                 ....*...
gi 300487159 158 LYMLITTQ 165
Cdd:COG0651  423 VRIFGRAQ 430
PRK06473 PRK06473
NADH-quinone oxidoreductase subunit M;
23-161 4.45e-15

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 235810 [Multi-domain]  Cd Length: 500  Bit Score: 72.81  E-value: 4.45e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  23 SSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTNYERIHSRTMILARGL---Q 99
Cdd:PRK06473 286 ASCAIAQKDMKKMVAYSSIGHMGYILLAAAAATPLSILAAVFQMISHGLISALLFLLVGVVYKKTGSRDVDVLRGLlnpE 365
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300487159 100 TILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGTNVVITALYSLYML 161
Cdd:PRK06473 366 RGLPITGSLMILGVMASAGIPGMVGFIAEFLVFRGSFPIFPVQTLLCMIGTGLTAVYFLLLV 427
ndhD CHL00011
NADH dehydrogenase subunit 4
19-161 6.34e-15

NADH dehydrogenase subunit 4


Pssm-ID: 176954 [Multi-domain]  Cd Length: 498  Bit Score: 72.29  E-value: 6.34e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  19 MIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTNYERIhsRTMILAR-- 96
Cdd:CHL00011 288 IIYAASTSLGQRNLKKRIAYSSVSHMGFIIIGIGSITDTGLNGAILQIISHGFIGAALFFLAGTSYDRI--RLVYLDEmg 365
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300487159  97 GLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLT-------SFYWSNITMLLMGTNVVITALYSLYML 161
Cdd:CHL00011 366 GIAIPMPKIFTMFSSFSMASLALPGMSGFVAELIVFFGiitsqkyLLMPKILITFVMAIGMILTPIYLLSML 437
PRK02546 PRK02546
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
29-161 1.54e-13

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 235050 [Multi-domain]  Cd Length: 525  Bit Score: 68.58  E-value: 1.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  29 QTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTNYERIHSRTMILARGLQTILPLMSAW 108
Cdd:PRK02546 300 QRNLKRKIAYSSISHMGFVLIGIGSFTDLGTSGAMLQMISHGLIGASLFFLVGATYDRTHTLMLDEMGGVGQKMRKMFAM 379
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159 109 WLLASLTNLALPPTINLIGELFI---MLTSFYWSN----ITMLLMGTNVVITALYSLYML 161
Cdd:PRK02546 380 WTACSLASLALPGMSGFVAELMVfvgFATSDAYTLpfrvVVVFLAAVGVILTPIYLLSML 439
PRK07363 PRK07363
NADH-quinone oxidoreductase subunit M;
14-201 3.37e-11

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 180945 [Multi-domain]  Cd Length: 501  Bit Score: 61.65  E-value: 3.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  14 LSLWGMIMT---SSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTNYERIHSR 90
Cdd:PRK07363 274 LAIIGTISViygALSAIAQKDIKRMVAYSSIGHMGYILVAAAAGTQLSLLGAVAQMISHGLILALLFHLVGIVERKVGTR 353
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  91 TMILARGLQTI---LPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGTNVVITALYSLYMLITTQRG 167
Cdd:PRK07363 354 DLDVLNGLMNPirgLPLTSALLVLAGMASAGIPGLVGFVAEFIVFQGSFSTFPIPTLLCIVASGLTAVYFVILLNRTCFG 433
                        170       180       190
                 ....*....|....*....|....*....|....
gi 300487159 168 KYSYHVNTIKPTFTRENSLMALHMIPLLLLSINP 201
Cdd:PRK07363 434 RLDNKLAYYPKVLWSEKIPALILTALILFLGVQP 467
PRK06458 PRK06458
hydrogenase 4 subunit F; Validated
27-155 3.75e-11

hydrogenase 4 subunit F; Validated


Pssm-ID: 235805 [Multi-domain]  Cd Length: 490  Bit Score: 61.48  E-value: 3.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  27 LRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTNYERIHSRTMILARGLQTILPLMS 106
Cdd:PRK06458 300 LRQRDIKRLFAYSSIEHMGLIAFALGIGGPLGIFAALLHMLNHSLTKSAIFFASGNVLQKYGTRDINVIRGLLKVSPLTG 379
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 300487159 107 AWWLLASLTNLALPPTINLIGELFIMLTSF---YWSNITMLLMGTNVVITAL 155
Cdd:PRK06458 380 WGLMLGALAIAGMPPFGVFISEFLILTAGLargPLLIAILLLLLLTLAFAAL 431
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
4-156 5.00e-11

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 61.05  E-value: 5.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159   4 TETMAYPFLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTN 83
Cdd:PRK08375 267 ALGLGWLLAVLALLSMLVGSLAALGQDDVKRVLAYSTVSQMGYILLGLALLTPLALAAGLLHLLHHALMKGALFLAAGAI 346
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300487159  84 YERIHSRTMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFY---WSNITMLLMGTnvVITALY 156
Cdd:PRK08375 347 EVTYGTRRLSELSGLGRRMPLTAAAFAVASLSLIGVPPTSGFVSKWYLVVGAVEagqWLVLAVLLASS--LLALLY 420
PRK12667 PRK12667
putative monovalent cation/H+ antiporter subunit D; Reviewed
11-199 4.24e-10

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237167 [Multi-domain]  Cd Length: 520  Bit Score: 58.44  E-value: 4.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  11 FLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTNYERIHSR 90
Cdd:PRK12667 298 LIILGAVSAIIGALMMVVQKDVKRLLAYSTISHMGYIFMGIGIGTQLGLAAALFHIINHAIAKSLLFLASGVFIHAAGTR 377
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  91 TMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFI----MLTSFYWSNITMLLMGtnvVITALYSLYMLITTQR 166
Cdd:PRK12667 378 DIDELAGLGRKMPIASFAFLIGALSLVGIPPLNGFFSKLLLfnalLESGFYLPALVLLIAS---AISLVGYFRAWYSLFF 454
                        170       180       190
                 ....*....|....*....|....*....|...
gi 300487159 167 GKYSYHVNTIKptftRENSLMALhmiPLLLLSI 199
Cdd:PRK12667 455 GKPKSGEEVEH----KESPSMSV---VILVLAL 480
PRK12647 PRK12647
putative monovalent cation/H+ antiporter subunit A; Reviewed
11-127 1.74e-08

putative monovalent cation/H+ antiporter subunit A; Reviewed


Pssm-ID: 237156 [Multi-domain]  Cd Length: 761  Bit Score: 53.77  E-value: 1.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  11 FLLLSLWG---MIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTNYERI 87
Cdd:PRK12647 259 QTILPLFGgltMLTGALLAVRQTDLKLILAYSTVSALGTLVMLLGLGSELAIKAAVLFLVAHSLYKGALFMVAGIIDHET 338
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 300487159  88 HSRTMILARGLQTILPLMSAWWLLASLTNLALPPTINLIG 127
Cdd:PRK12647 339 GTRDITKLGGLRRAMPITAAAALLAALSMAGLPPLFGFLA 378
PRK12662 PRK12662
putative monovalent cation/H+ antiporter subunit D; Reviewed
11-148 5.07e-07

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 183662 [Multi-domain]  Cd Length: 492  Bit Score: 49.35  E-value: 5.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  11 FLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTNYERIHSR 90
Cdd:PRK12662 282 FMILAALAIVFGSVLAILSKDIKRIFAYSSISHIGYIILAVSLNTYYGLAAAVAYIVNHSIVKSALFMVSGSISYHFGTT 361
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 300487159  91 TMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIM---LTSFYWSNITMLLMGT 148
Cdd:PRK12662 362 KLEDCLNLWKSMPKITLAFVLLSLSLIGMPPTSGFVAKWYILdafIKSNAWIGLVVLLVGS 422
PRK12650 PRK12650
DUF4040 family protein;
12-126 9.68e-07

DUF4040 family protein;


Pssm-ID: 237158 [Multi-domain]  Cd Length: 962  Bit Score: 48.50  E-value: 9.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  12 LLLSLWGM---IMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTNYERIH 88
Cdd:PRK12650 273 WLLIIVGMitaLMGAVFAVQKTDLKKLTAYSTVSQLGWIVATIGVGTPFALTAAVVHTLAHALFKSSLFMLIGVVDHQAG 352
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 300487159  89 SRTMILARGLQTILPLMSAWWLLASLTNLALPPTINLI 126
Cdd:PRK12650 353 TRDIRRLGSLWRRMPFTFVSVTIAALSMAAVPPLFGFV 390
NuoL COG1009
Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ ...
19-199 1.07e-06

Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion]; Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440633 [Multi-domain]  Cd Length: 608  Bit Score: 48.22  E-value: 1.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  19 MIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQtpwSFMGATALMIAHGLTSSMLFCLANTNYERIHSRTMILARGL 98
Cdd:COG1009  286 ALFAALIALAQTDIKRVLAYSTVSQLGYMFLALGVG---AYVAALFHLLTHAFFKALLFLGAGSVIHATGTRDIRKMGGL 362
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  99 QTILPLMSAWWLLASLTNLALPPTINLIG-ELFI--MLTSFYWSNITMLLMGTNVVITALYSLYMLITT----QRGKYSY 171
Cdd:COG1009  363 RKKMPITAITFLIGALSLAGIPPFAGFFSkEAILeaALEAGGLGPLLLAVALLGAFLTAFYSFRLFFLVffgkPRPKTPK 442
                        170       180
                 ....*....|....*....|....*...
gi 300487159 172 HVNTIKPTFTrenslmalhmIPLLLLSI 199
Cdd:COG1009  443 HPHESPWLMT----------LPLVVLAV 460
PRK06589 PRK06589
putative monovalent cation/H+ antiporter subunit D; Reviewed
19-161 1.15e-06

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 235835 [Multi-domain]  Cd Length: 489  Bit Score: 48.27  E-value: 1.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  19 MIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTNYERIHSRTMILARGL 98
Cdd:PRK06589 291 IFYSSLKALKTDNIKKILAYSTISQLSLALLSAFILTPKALGAAILHLVSHSFAKICLFYSMGSIYSLKKEDQVDKLHGT 370
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300487159  99 QTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGTNVVI--TALYSLYML 161
Cdd:PRK06589 371 SKSFPLISFIISISSLSLIGIPIFSGFISKFLILLAASEQNQPWLSIIVMLVVIasSILSALYLL 435
PRK06525 PRK06525
hydrogenase 4 subunit D; Validated
1-199 4.54e-06

hydrogenase 4 subunit D; Validated


Pssm-ID: 180606 [Multi-domain]  Cd Length: 479  Bit Score: 46.51  E-value: 4.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159   1 NPITETMAYPFLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQ---TPWSFMGATALMIAHGLTSSMLF 77
Cdd:PRK06525 265 GPIPHVIGYVGAVMAIVTLLYGFLMYLPQQDMKRLLAYSTITQLGYMFFGLSLAilgSRLALEGSIAYIFNHAFAKSLFF 344
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  78 CLANTNYERIHSRTMILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTSFYWSNITMLLMGTNVVITA--- 154
Cdd:PRK06525 345 LVAGALSYSCGTRLLPRLRGVLKKLPLVGVGFCVAALAITGVPPFNGFFSKFPIFAAGFELSVEYWILLPAMVLLLIesv 424
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 300487159 155 ---LYSLYMLITTQRGKYSYHVNTIKPtftrENSLMALHMIPLLLLSI 199
Cdd:PRK06525 425 asfAWFLRWFGRVVFGEPSEAVADAAP----LPGSMKLVLIVLIVMSL 468
PRK08377 PRK08377
NADH dehydrogenase subunit N; Validated
12-156 6.27e-06

NADH dehydrogenase subunit N; Validated


Pssm-ID: 181406 [Multi-domain]  Cd Length: 494  Bit Score: 45.91  E-value: 6.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  12 LLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTNYERIHSRT 91
Cdd:PRK08377 277 IIMATLTVFFAELSALRQKNVKRMIAYSSIGQVGMIALALALGTQAGVDAGVFHMINHAIVKALLFLAVGYVGITLGGTE 356
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300487159  92 MILARGLQTILPLMSAWWLLASLTNLALPPTINLIGELFIMLTS----FYWsnITMLLMGTNVVITALY 156
Cdd:PRK08377 357 IEKFEGLGKRMPLTALALTIGALSTVGIPLFNVFWSKFRIILAGlsagYTW--PVALVLGASVVEAVYY 423
PRK08676 PRK08676
hydrogenase membrane subunit; Validated
27-135 8.45e-05

hydrogenase membrane subunit; Validated


Pssm-ID: 181537 [Multi-domain]  Cd Length: 485  Bit Score: 42.43  E-value: 8.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  27 LRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTnYERIHSRTMILARGLQTILPLMS 106
Cdd:PRK08676 292 LSQRNLKKLIAFSSIEHMGLMLLGIGIGTPLALFWMLFHMLAHSLVKSGLFFSAGI-LHRQYRSDRFDRIFDVFRLQPVA 370
                         90       100       110
                 ....*....|....*....|....*....|
gi 300487159 107 AWWL-LASLTNLALPPTINLIGELFIMLTS 135
Cdd:PRK08676 371 AWGViLGSAAIIGMPPFPLFLSKFFILLQL 400
PRK08668 PRK08668
NADH dehydrogenase subunit M; Validated
6-77 1.96e-04

NADH dehydrogenase subunit M; Validated


Pssm-ID: 236332 [Multi-domain]  Cd Length: 610  Bit Score: 41.52  E-value: 1.96e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300487159   6 TMAYPFLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLF 77
Cdd:PRK08668 270 LFNYILAWLGNISIIVGTLMAILQEDIKKLIAYSSVANGGYILVGLGLGTSLGFAGGLFHVFNHALFKGLFF 341
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
27-206 2.50e-04

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 41.26  E-value: 2.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  27 LRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLF-CLANTNYERIHSRTMILARGLQTILPLM 105
Cdd:COG1007  288 LAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLGVSAALFYLLAYLFMNLGAFaVILLLSRKGGEAEEIEDLAGLARRSPLL 367
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159 106 sAWWLLASLTNLA-LPPTINLIGELFIML----TSFYWSNITMLLmgtNVVITALYSLYMLITTQRGKYSYHVNTIKPTF 180
Cdd:COG1007  368 -ALAMTIFLLSLAgIPPTAGFFGKFYVFSaaveAGLYWLAVIAVL---NSVISAYYYLRVVKAMYFDEPEEEAPISAPPG 443
                        170       180
                 ....*....|....*....|....*.
gi 300487159 181 TRenSLMALHMIPLLLLSINPKLILG 206
Cdd:COG1007  444 LR--VALVIAALLVLLLGIFPGPLLD 467
PRK08667 PRK08667
hydrogenase membrane subunit; Validated
27-139 3.05e-04

hydrogenase membrane subunit; Validated


Pssm-ID: 236331 [Multi-domain]  Cd Length: 644  Bit Score: 40.87  E-value: 3.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  27 LRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALM-----------IAHGLTSSMLFCLANTNYERIHSRTMILA 95
Cdd:PRK08667 289 LKEHDLKGLLAYSSIENIGIILMGIGLYVIFGVYGLDTLAllalggalfhsLNHALFKSLLFLTAGSVVHATGTRNIEKM 368
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 300487159  96 RGLQTILPLMSAWWLLASLTNLALPPTINLIGELFImLTSFYWS 139
Cdd:PRK08667 369 GGLVKLMPYTSALFLVGAVSIAALPPFNGFASELLL-YESFFQS 411
PRK06277 PRK06277
energy conserving hydrogenase EhbF;
12-121 3.09e-04

energy conserving hydrogenase EhbF;


Pssm-ID: 235767 [Multi-domain]  Cd Length: 478  Bit Score: 40.79  E-value: 3.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300487159  12 LLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLFCLANTNYERIHSRT 91
Cdd:PRK06277 270 IALSVLAMVFGVVMALLQTDYKRLLAYHAISQGGYVAAGLALGTPLGIVAGIFHAINHVIYKSALFLGAGIVSYRTKTSN 349
                         90       100       110
                 ....*....|....*....|....*....|
gi 300487159  92 MILARGLQTILPLMSAWWLLASLTNLALPP 121
Cdd:PRK06277 350 LRKLGGLLPVMPVVAFMVLCAKLAISGVPP 379
PRK12644 PRK12644
putative monovalent cation/H+ antiporter subunit A; Reviewed
12-77 3.10e-04

putative monovalent cation/H+ antiporter subunit A; Reviewed


Pssm-ID: 237154 [Multi-domain]  Cd Length: 965  Bit Score: 41.06  E-value: 3.10e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300487159  12 LLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTSSMLF 77
Cdd:PRK12644 271 LVLGLATMLLGGWRALRQHDLKLILAYGTVSQLGFLTVLVGIGTRDAALAGLAMLLAHALFKAALF 336
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
2-73 5.22e-03

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 37.11  E-value: 5.22e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300487159   2 PITETMAYPFLLLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIIAILIQTPWSFMGATALMIAHGLTS 73
Cdd:PRK05777 264 GLSEDWQQVLAIIAIASMLVGNLAALSQTNIKRLLAYSSIAHAGYLLVGLAAGTAEGYSAVLFYLLAYLFMT 335
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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