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Conserved domains on  [gi|321173297|gb|ADW77422|]
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POU domain transcription factor OCT4-pg1 [Homo sapiens]

Protein Classification

POU family transcription factor( domain architecture ID 11265437)

POU (Pit-Oct-Unc) family transcription factor binds specific DNA sequences to direct gene expression programs, playing a role in orchestrating embryonic development and directing cellular fate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
138-212 8.71e-46

Found in Pit-Oct-Unc transcription factors;


:

Pssm-ID: 197673  Cd Length: 75  Bit Score: 151.05  E-value: 8.71e-46
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 321173297   138 DIKALQKELEQFAKLLKQKRITLGYTQADVGLILGVLFGKVFSQTTICRFEALQLSFKNMCKLRPLLQKWVEEAD 212
Cdd:smart00352   1 DDDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Homeodomain pfam00046
Homeodomain;
231-286 2.81e-19

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 80.24  E-value: 2.81e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 321173297  231 KRKRTSIENRVRGNLENLFLQCPKPTLQ-ISHIAQQLGLEKDVVRVWFCNRRQKGKR 286
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEeREELAAQLGLTERQVKVWFQNRRAKWKR 57
 
Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
138-212 8.71e-46

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 151.05  E-value: 8.71e-46
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 321173297   138 DIKALQKELEQFAKLLKQKRITLGYTQADVGLILGVLFGKVFSQTTICRFEALQLSFKNMCKLRPLLQKWVEEAD 212
Cdd:smart00352   1 DDDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
143-212 2.37e-42

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 142.03  E-value: 2.37e-42
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321173297  143 QKELEQFAKLLKQKRITLGYTQADVGLILGVLFGKVFSQTTICRFEALQLSFKNMCKLRPLLQKWVEEAD 212
Cdd:pfam00157   3 LEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICRFEKLDLSLKNMCKLKPLLEKWLEEAE 72
Homeodomain pfam00046
Homeodomain;
231-286 2.81e-19

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 80.24  E-value: 2.81e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 321173297  231 KRKRTSIENRVRGNLENLFLQCPKPTLQ-ISHIAQQLGLEKDVVRVWFCNRRQKGKR 286
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEeREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 230-285 2.00e-14

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 66.89  E-value: 2.00e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 321173297   230 RKRKRTSIENRVRGNLENLFLQCPKPTLQ-ISHIAQQLGLEKDVVRVWFCNRRQKGK 285
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREeREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 231-288 3.73e-14

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 66.50  E-value: 3.73e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 321173297 231 KRKRTSIENRVRGNLENLFLQCPKPTLQ-ISHIAQQLGLEKDVVRVWFCNRRQKGKRSS 288
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREeREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
230-289 1.17e-04

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 42.04  E-value: 1.17e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 321173297 230 RKRKRTSIENRVRgnLENLFLQCPKPTL-QISHIAQQLGLEKDVVRVWFCNRRQKGKRSSS 289
Cdd:COG5576   53 SKRRRTTDEQLMV--LEREFEINPYPSSiTRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRS 111
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
147-188 2.14e-03

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 36.36  E-value: 2.14e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 321173297 147 EQFAKLLKQKRITLGYTQADVGLILGVlfgkvfSQTTICRFE 188
Cdd:COG1476    3 KKLGNRLKELRKERGLTQEELAELLGV------SRQTISAIE 38
 
Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
138-212 8.71e-46

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 151.05  E-value: 8.71e-46
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 321173297   138 DIKALQKELEQFAKLLKQKRITLGYTQADVGLILGVLFGKVFSQTTICRFEALQLSFKNMCKLRPLLQKWVEEAD 212
Cdd:smart00352   1 DDDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
143-212 2.37e-42

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 142.03  E-value: 2.37e-42
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321173297  143 QKELEQFAKLLKQKRITLGYTQADVGLILGVLFGKVFSQTTICRFEALQLSFKNMCKLRPLLQKWVEEAD 212
Cdd:pfam00157   3 LEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICRFEKLDLSLKNMCKLKPLLEKWLEEAE 72
Homeodomain pfam00046
Homeodomain;
231-286 2.81e-19

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 80.24  E-value: 2.81e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 321173297  231 KRKRTSIENRVRGNLENLFLQCPKPTLQ-ISHIAQQLGLEKDVVRVWFCNRRQKGKR 286
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEeREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 230-285 2.00e-14

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 66.89  E-value: 2.00e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 321173297   230 RKRKRTSIENRVRGNLENLFLQCPKPTLQ-ISHIAQQLGLEKDVVRVWFCNRRQKGK 285
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREeREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 231-288 3.73e-14

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 66.50  E-value: 3.73e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 321173297 231 KRKRTSIENRVRGNLENLFLQCPKPTLQ-ISHIAQQLGLEKDVVRVWFCNRRQKGKRSS 288
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREeREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
230-289 1.17e-04

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 42.04  E-value: 1.17e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 321173297 230 RKRKRTSIENRVRgnLENLFLQCPKPTL-QISHIAQQLGLEKDVVRVWFCNRRQKGKRSSS 289
Cdd:COG5576   53 SKRRRTTDEQLMV--LEREFEINPYPSSiTRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRS 111
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
147-188 2.14e-03

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 36.36  E-value: 2.14e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 321173297 147 EQFAKLLKQKRITLGYTQADVGLILGVlfgkvfSQTTICRFE 188
Cdd:COG1476    3 KKLGNRLKELRKERGLTQEELAELLGV------SRQTISAIE 38
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
144-188 2.52e-03

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 36.51  E-value: 2.52e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 321173297 144 KELEQFAKLLKQKRITLGYTQADVGLILGVlfgkvfSQTTICRFE 188
Cdd:COG1396    3 TLKKALGERLRELRKARGLTQEELAERLGV------SRSTISRIE 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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