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Conserved domains on  [gi|345447168|gb|AEN92170|]
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GH family 7 cellobiohydrolase, partial [Zhuliangomyces illinitus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GH7_CBH_EG super family cl21662
Glycosyl hydrolase family 7; Glycosyl hydrolase family 7 contains eukaryotic endoglucanases ...
 1-170 2.41e-125

Glycosyl hydrolase family 7; Glycosyl hydrolase family 7 contains eukaryotic endoglucanases (EGs) and cellobiohydrolases (CBHs) that hydrolyze glycosidic bonds using a double-displacement mechanism. This leads to a net retention of the conformation at the anomeric carbon. Both enzymes work synergistically in the degradation of cellulose,which is the main component of plant cell wall, and is composed of beta-1,4 linked glycosyl units. EG cleaves the beta-1,4 linkages of cellulose and CBH cleaves off cellobiose disaccharide units from the reducing end of the chain. In general, the O-glycosyl hydrolases are a widespread group of enzymes that hydrolyze the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A glycosyl hydrolase classification system based on sequence similarity has led to the definition of more than 95 different families inlcuding glycoside hydrolase family 7.


The actual alignment was detected with superfamily member pfam00840:

Pssm-ID: 473929  Cd Length: 434  Bit Score: 358.83  E-value: 2.41e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345447168    1 TNCYTGNTWDKTLCPDDATCAKNCALEGADYPGTYGITASGNALTLKFVTSSQQ-KNIGSRVYLMA-DDSHYQMFNLLNQ 78
Cdd:pfam00840  46 TNCYTGNTWDTTLCPDAATCAKNCALDGADYSGTYGITTSGDALTLKFVTKGQYgKNVGSRVYLLAeDGTKYQMFKLLNQ 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345447168   79 EFTFDVDVSNLPCGLNGAVYFSSMDADGGASKFPNNKAGAKYGTGYCDSQCPRDIKFINGEGNSDGWSGSPNDVNAGTGN 158
Cdd:pfam00840 126 EFTFDVDVSKLPCGLNGALYFVEMDADGGMSKYPTNKAGAKYGTGYCDAQCPRDLKFINGEANIEGWTPSSNDANAGVGK 205

                         170
                  ....*....|..
gi 345447168  159 YGTCCSEMDIWE 170
Cdd:pfam00840 206 YGACCAEMDIWE 217
 
Name Accession Description Interval E-value
Glyco_hydro_7 pfam00840
Glycosyl hydrolase family 7;
1-170 2.41e-125

Glycosyl hydrolase family 7;


Pssm-ID: 459958  Cd Length: 434  Bit Score: 358.83  E-value: 2.41e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345447168    1 TNCYTGNTWDKTLCPDDATCAKNCALEGADYPGTYGITASGNALTLKFVTSSQQ-KNIGSRVYLMA-DDSHYQMFNLLNQ 78
Cdd:pfam00840  46 TNCYTGNTWDTTLCPDAATCAKNCALDGADYSGTYGITTSGDALTLKFVTKGQYgKNVGSRVYLLAeDGTKYQMFKLLNQ 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345447168   79 EFTFDVDVSNLPCGLNGAVYFSSMDADGGASKFPNNKAGAKYGTGYCDSQCPRDIKFINGEGNSDGWSGSPNDVNAGTGN 158
Cdd:pfam00840 126 EFTFDVDVSKLPCGLNGALYFVEMDADGGMSKYPTNKAGAKYGTGYCDAQCPRDLKFINGEANIEGWTPSSNDANAGVGK 205

                         170
                  ....*....|..
gi 345447168  159 YGTCCSEMDIWE 170
Cdd:pfam00840 206 YGACCAEMDIWE 217
GH7_CBH_EG cd07999
Glycosyl hydrolase family 7; Glycosyl hydrolase family 7 contains eukaryotic endoglucanases ...
 1-170 3.95e-96

Glycosyl hydrolase family 7; Glycosyl hydrolase family 7 contains eukaryotic endoglucanases (EGs) and cellobiohydrolases (CBHs) that hydrolyze glycosidic bonds using a double-displacement mechanism. This leads to a net retention of the conformation at the anomeric carbon. Both enzymes work synergistically in the degradation of cellulose,which is the main component of plant cell wall, and is composed of beta-1,4 linked glycosyl units. EG cleaves the beta-1,4 linkages of cellulose and CBH cleaves off cellobiose disaccharide units from the reducing end of the chain. In general, the O-glycosyl hydrolases are a widespread group of enzymes that hydrolyze the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A glycosyl hydrolase classification system based on sequence similarity has led to the definition of more than 95 different families inlcuding glycoside hydrolase family 7.


Pssm-ID: 153432  Cd Length: 386  Bit Score: 283.16  E-value: 3.95e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345447168   1 TNCYTGNTWDKTLCPDDATCAKNCALEGADYPGTYGITASGNALTLKFVTSSQQKNIGSRVYLMADDSHYQMFNLLNQEF 80
Cdd:cd07999   41 TCCYGGNWWNATLCPDEATCAKNCALEGADYAGTYGVTTSGNSLTLNFVTPDGYKNVGSRVYLLADDSKYQMFKLLGQEF 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345447168  81 TFDVDVSNLPCGLNGAVYFSSMDADGGASKFPNNKAGAKYGTGYCDSQCPRDIKFINGEgnsdgwsgspndvnAGTGNYG 160
Cdd:cd07999  121 TFDVDMSNLPCGMNGALYLSEMDADGGMSKYPSNPAGAKYGTGYCDAQCPRDLKFIGGE--------------AGIGGYG 186

                        170
                 ....*....|
gi 345447168 161 TCCSEMDIWE 170
Cdd:cd07999  187 SCCNEMDIWE 196
 
Name Accession Description Interval E-value
Glyco_hydro_7 pfam00840
Glycosyl hydrolase family 7;
1-170 2.41e-125

Glycosyl hydrolase family 7;


Pssm-ID: 459958  Cd Length: 434  Bit Score: 358.83  E-value: 2.41e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345447168    1 TNCYTGNTWDKTLCPDDATCAKNCALEGADYPGTYGITASGNALTLKFVTSSQQ-KNIGSRVYLMA-DDSHYQMFNLLNQ 78
Cdd:pfam00840  46 TNCYTGNTWDTTLCPDAATCAKNCALDGADYSGTYGITTSGDALTLKFVTKGQYgKNVGSRVYLLAeDGTKYQMFKLLNQ 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345447168   79 EFTFDVDVSNLPCGLNGAVYFSSMDADGGASKFPNNKAGAKYGTGYCDSQCPRDIKFINGEGNSDGWSGSPNDVNAGTGN 158
Cdd:pfam00840 126 EFTFDVDVSKLPCGLNGALYFVEMDADGGMSKYPTNKAGAKYGTGYCDAQCPRDLKFINGEANIEGWTPSSNDANAGVGK 205

                         170
                  ....*....|..
gi 345447168  159 YGTCCSEMDIWE 170
Cdd:pfam00840 206 YGACCAEMDIWE 217
GH7_CBH_EG cd07999
Glycosyl hydrolase family 7; Glycosyl hydrolase family 7 contains eukaryotic endoglucanases ...
 1-170 3.95e-96

Glycosyl hydrolase family 7; Glycosyl hydrolase family 7 contains eukaryotic endoglucanases (EGs) and cellobiohydrolases (CBHs) that hydrolyze glycosidic bonds using a double-displacement mechanism. This leads to a net retention of the conformation at the anomeric carbon. Both enzymes work synergistically in the degradation of cellulose,which is the main component of plant cell wall, and is composed of beta-1,4 linked glycosyl units. EG cleaves the beta-1,4 linkages of cellulose and CBH cleaves off cellobiose disaccharide units from the reducing end of the chain. In general, the O-glycosyl hydrolases are a widespread group of enzymes that hydrolyze the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A glycosyl hydrolase classification system based on sequence similarity has led to the definition of more than 95 different families inlcuding glycoside hydrolase family 7.


Pssm-ID: 153432  Cd Length: 386  Bit Score: 283.16  E-value: 3.95e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345447168   1 TNCYTGNTWDKTLCPDDATCAKNCALEGADYPGTYGITASGNALTLKFVTSSQQKNIGSRVYLMADDSHYQMFNLLNQEF 80
Cdd:cd07999   41 TCCYGGNWWNATLCPDEATCAKNCALEGADYAGTYGVTTSGNSLTLNFVTPDGYKNVGSRVYLLADDSKYQMFKLLGQEF 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345447168  81 TFDVDVSNLPCGLNGAVYFSSMDADGGASKFPNNKAGAKYGTGYCDSQCPRDIKFINGEgnsdgwsgspndvnAGTGNYG 160
Cdd:cd07999  121 TFDVDMSNLPCGMNGALYLSEMDADGGMSKYPSNPAGAKYGTGYCDAQCPRDLKFIGGE--------------AGIGGYG 186

                        170
                 ....*....|
gi 345447168 161 TCCSEMDIWE 170
Cdd:cd07999  187 SCCNEMDIWE 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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