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Conserved domains on  [gi|345505108|gb|AEN99779|]
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cellobiohydrolase I, partial [Trametes sp. L]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GH7_CBH_EG super family cl21662
Glycosyl hydrolase family 7; Glycosyl hydrolase family 7 contains eukaryotic endoglucanases ...
 1-170 1.92e-125

Glycosyl hydrolase family 7; Glycosyl hydrolase family 7 contains eukaryotic endoglucanases (EGs) and cellobiohydrolases (CBHs) that hydrolyze glycosidic bonds using a double-displacement mechanism. This leads to a net retention of the conformation at the anomeric carbon. Both enzymes work synergistically in the degradation of cellulose,which is the main component of plant cell wall, and is composed of beta-1,4 linked glycosyl units. EG cleaves the beta-1,4 linkages of cellulose and CBH cleaves off cellobiose disaccharide units from the reducing end of the chain. In general, the O-glycosyl hydrolases are a widespread group of enzymes that hydrolyze the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A glycosyl hydrolase classification system based on sequence similarity has led to the definition of more than 95 different families inlcuding glycoside hydrolase family 7.


The actual alignment was detected with superfamily member pfam00840:

Pssm-ID: 473929  Cd Length: 434  Bit Score: 359.21  E-value: 1.92e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345505108    1 CYTGNTWDSSLCPDPTTCAKNCALDGADYAGTYGITTSGNQLSLKFVTHGQYSTNIGSRVYLLDGSDSKYQQFNLKNQEF 80
Cdd:pfam00840  48 CYTGNTWDTTLCPDAATCAKNCALDGADYSGTYGITTSGDALTLKFVTKGQYGKNVGSRVYLLAEDGTKYQMFKLLNQEF 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345505108   81 TFDIDMSKLPCGLNGALYFVEMDADGGLSRFPSNKAGAKYGTGYCDTQCPHDIKFINGEqANVLGWTPSDSDPNAGSGQY 160
Cdd:pfam00840 128 TFDVDVSKLPCGLNGALYFVEMDADGGMSKYPTNKAGAKYGTGYCDAQCPRDLKFINGE-ANIEGWTPSSNDANAGVGKY 206

                         170
                  ....*....|
gi 345505108  161 GTCCNEMDIW 170
Cdd:pfam00840 207 GACCAEMDIW 216
 
Name Accession Description Interval E-value
Glyco_hydro_7 pfam00840
Glycosyl hydrolase family 7;
1-170 1.92e-125

Glycosyl hydrolase family 7;


Pssm-ID: 459958  Cd Length: 434  Bit Score: 359.21  E-value: 1.92e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345505108    1 CYTGNTWDSSLCPDPTTCAKNCALDGADYAGTYGITTSGNQLSLKFVTHGQYSTNIGSRVYLLDGSDSKYQQFNLKNQEF 80
Cdd:pfam00840  48 CYTGNTWDTTLCPDAATCAKNCALDGADYSGTYGITTSGDALTLKFVTKGQYGKNVGSRVYLLAEDGTKYQMFKLLNQEF 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345505108   81 TFDIDMSKLPCGLNGALYFVEMDADGGLSRFPSNKAGAKYGTGYCDTQCPHDIKFINGEqANVLGWTPSDSDPNAGSGQY 160
Cdd:pfam00840 128 TFDVDVSKLPCGLNGALYFVEMDADGGMSKYPTNKAGAKYGTGYCDAQCPRDLKFINGE-ANIEGWTPSSNDANAGVGKY 206

                         170
                  ....*....|
gi 345505108  161 GTCCNEMDIW 170
Cdd:pfam00840 207 GACCAEMDIW 216
GH7_CBH_EG cd07999
Glycosyl hydrolase family 7; Glycosyl hydrolase family 7 contains eukaryotic endoglucanases ...
 1-170 7.15e-88

Glycosyl hydrolase family 7; Glycosyl hydrolase family 7 contains eukaryotic endoglucanases (EGs) and cellobiohydrolases (CBHs) that hydrolyze glycosidic bonds using a double-displacement mechanism. This leads to a net retention of the conformation at the anomeric carbon. Both enzymes work synergistically in the degradation of cellulose,which is the main component of plant cell wall, and is composed of beta-1,4 linked glycosyl units. EG cleaves the beta-1,4 linkages of cellulose and CBH cleaves off cellobiose disaccharide units from the reducing end of the chain. In general, the O-glycosyl hydrolases are a widespread group of enzymes that hydrolyze the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A glycosyl hydrolase classification system based on sequence similarity has led to the definition of more than 95 different families inlcuding glycoside hydrolase family 7.


Pssm-ID: 153432  Cd Length: 386  Bit Score: 261.98  E-value: 7.15e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345505108   1 CYTGNTWDSSLCPDPTTCAKNCALDGADYAGTYGITTSGNQLSLKFVTHGQYStNIGSRVYLLDgSDSKYQQFNLKNQEF 80
Cdd:cd07999   43 CYGGNWWNATLCPDEATCAKNCALEGADYAGTYGVTTSGNSLTLNFVTPDGYK-NVGSRVYLLA-DDSKYQMFKLLGQEF 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345505108  81 TFDIDMSKLPCGLNGALYFVEMDADGGLSRFPSNKAGAKYGTGYCDTQCPHDIKFINGEqanvlgwtpsdsdpnAGSGQY 160
Cdd:cd07999  121 TFDVDMSNLPCGMNGALYLSEMDADGGMSKYPSNPAGAKYGTGYCDAQCPRDLKFIGGE---------------AGIGGY 185

                        170
                 ....*....|
gi 345505108 161 GTCCNEMDIW 170
Cdd:cd07999  186 GSCCNEMDIW 195
PRK13211 PRK13211
N-acetylglucosamine-binding protein GbpA;
30-108 7.63e-03

N-acetylglucosamine-binding protein GbpA;


Pssm-ID: 237309 [Multi-domain]  Cd Length: 478  Bit Score: 36.14  E-value: 7.63e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 345505108  30 AGTYGITTSGNQLSLKFVTHGQysTNIGSRVYLLDGSDSKYQQFNLKNQEFTFDIDMSKLPCGLNGALYFVEmDADGGL 108
Cdd:PRK13211 319 AKEYKIGDGAATLDFTVTATGD--MNVEATVYNHDGEALGSKSQTVNDGSQSVSLDLSKLKAGHHMLVVKAK-PKDGEL 394
 
Name Accession Description Interval E-value
Glyco_hydro_7 pfam00840
Glycosyl hydrolase family 7;
1-170 1.92e-125

Glycosyl hydrolase family 7;


Pssm-ID: 459958  Cd Length: 434  Bit Score: 359.21  E-value: 1.92e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345505108    1 CYTGNTWDSSLCPDPTTCAKNCALDGADYAGTYGITTSGNQLSLKFVTHGQYSTNIGSRVYLLDGSDSKYQQFNLKNQEF 80
Cdd:pfam00840  48 CYTGNTWDTTLCPDAATCAKNCALDGADYSGTYGITTSGDALTLKFVTKGQYGKNVGSRVYLLAEDGTKYQMFKLLNQEF 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345505108   81 TFDIDMSKLPCGLNGALYFVEMDADGGLSRFPSNKAGAKYGTGYCDTQCPHDIKFINGEqANVLGWTPSDSDPNAGSGQY 160
Cdd:pfam00840 128 TFDVDVSKLPCGLNGALYFVEMDADGGMSKYPTNKAGAKYGTGYCDAQCPRDLKFINGE-ANIEGWTPSSNDANAGVGKY 206

                         170
                  ....*....|
gi 345505108  161 GTCCNEMDIW 170
Cdd:pfam00840 207 GACCAEMDIW 216
GH7_CBH_EG cd07999
Glycosyl hydrolase family 7; Glycosyl hydrolase family 7 contains eukaryotic endoglucanases ...
 1-170 7.15e-88

Glycosyl hydrolase family 7; Glycosyl hydrolase family 7 contains eukaryotic endoglucanases (EGs) and cellobiohydrolases (CBHs) that hydrolyze glycosidic bonds using a double-displacement mechanism. This leads to a net retention of the conformation at the anomeric carbon. Both enzymes work synergistically in the degradation of cellulose,which is the main component of plant cell wall, and is composed of beta-1,4 linked glycosyl units. EG cleaves the beta-1,4 linkages of cellulose and CBH cleaves off cellobiose disaccharide units from the reducing end of the chain. In general, the O-glycosyl hydrolases are a widespread group of enzymes that hydrolyze the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A glycosyl hydrolase classification system based on sequence similarity has led to the definition of more than 95 different families inlcuding glycoside hydrolase family 7.


Pssm-ID: 153432  Cd Length: 386  Bit Score: 261.98  E-value: 7.15e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345505108   1 CYTGNTWDSSLCPDPTTCAKNCALDGADYAGTYGITTSGNQLSLKFVTHGQYStNIGSRVYLLDgSDSKYQQFNLKNQEF 80
Cdd:cd07999   43 CYGGNWWNATLCPDEATCAKNCALEGADYAGTYGVTTSGNSLTLNFVTPDGYK-NVGSRVYLLA-DDSKYQMFKLLGQEF 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345505108  81 TFDIDMSKLPCGLNGALYFVEMDADGGLSRFPSNKAGAKYGTGYCDTQCPHDIKFINGEqanvlgwtpsdsdpnAGSGQY 160
Cdd:cd07999  121 TFDVDMSNLPCGMNGALYLSEMDADGGMSKYPSNPAGAKYGTGYCDAQCPRDLKFIGGE---------------AGIGGY 185

                        170
                 ....*....|
gi 345505108 161 GTCCNEMDIW 170
Cdd:cd07999  186 GSCCNEMDIW 195
PRK13211 PRK13211
N-acetylglucosamine-binding protein GbpA;
30-108 7.63e-03

N-acetylglucosamine-binding protein GbpA;


Pssm-ID: 237309 [Multi-domain]  Cd Length: 478  Bit Score: 36.14  E-value: 7.63e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 345505108  30 AGTYGITTSGNQLSLKFVTHGQysTNIGSRVYLLDGSDSKYQQFNLKNQEFTFDIDMSKLPCGLNGALYFVEmDADGGL 108
Cdd:PRK13211 319 AKEYKIGDGAATLDFTVTATGD--MNVEATVYNHDGEALGSKSQTVNDGSQSVSLDLSKLKAGHHMLVVKAK-PKDGEL 394
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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