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Conserved domains on  [gi|383397760|gb|AFH22538|]
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hypothetical protein OSG_eHP29_00070 [environmental Halophage eHP-29]

Protein Classification

DNA-methyltransferase( domain architecture ID 10002921)

DNA methyltransferase catalyzes specific methylation on cytosine or adenine on both strands and protects the DNA from cleavage by endonuclease; belongs to the class I SAM-dependent methyltransferase superfamily

CATH:  2.20.25.110
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
4-420 1.38e-40

DNA modification methylase [Replication, recombination and repair];


:

Pssm-ID: 440623  Cd Length: 236  Bit Score: 144.68  E-value: 1.38e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760   4 QIYTGDCFEQLPALDENSVHAIVTDPPYGLAFMGRS-------WDDFEpkEYQEWCEKWATECLRVLKPGGHLLAFSGNR 76
Cdd:COG0863    1 RLICGDCLEVLKELPDESVDLIVTDPPYNLGKKYGLgrreignELSFE--EYLEFLREWLAECYRVLKPGGSLYVNIGDR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760  77 THHRLMSGIEDAGYEIRDTITWHYGSGFPkaldvsksidkqagkkedrevtgkyhnpdGTTRDYdgydtscnvycdrids 156
Cdd:COG0863   79 YISRLIAALRDAGFKLRNEIIWRKPNGVP-----------------------------GPSKRR---------------- 113

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760 157 nehrqttepateqaeqwdgfksaLKPATEFVCVArsplaedtiaenvvthgtgalnidatrvesedggwtRKGPipdisg 236
Cdd:COG0863  114 -----------------------FRNSHEYILWF------------------------------------TKGK------ 128

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760 237 gsyaggnaengalgpsdmtqecddngRYPANVvfdaqqadvldDEVGELGGGSMTRngDVegkeWEndvnegytegrdrs 316
Cdd:COG0863  129 --------------------------KYTFNV-----------DAVKSIEDGRNPS--DV----WD-------------- 151

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760 317 mfvneaaddgvrsygdsggpsryfyTSKASKAERTLdgkidnaHPTVKPIDLMEWLVQLATAEEQIVLDPFAGSGTTCKA 396
Cdd:COG0863  152 -------------------------IPGVTPKERKG-------HPTQKPVELLERLILASSNPGDIVLDPFAGSGTTLVA 199

                        410       420
                 ....*....|....*....|....
gi 383397760 397 AKNKNRQFIGIEQQAKWADVARVR 420
Cdd:COG0863  200 AERLGRRFIGIEIDPEYVEVARRR 223
 
Name Accession Description Interval E-value
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
4-420 1.38e-40

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 144.68  E-value: 1.38e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760   4 QIYTGDCFEQLPALDENSVHAIVTDPPYGLAFMGRS-------WDDFEpkEYQEWCEKWATECLRVLKPGGHLLAFSGNR 76
Cdd:COG0863    1 RLICGDCLEVLKELPDESVDLIVTDPPYNLGKKYGLgrreignELSFE--EYLEFLREWLAECYRVLKPGGSLYVNIGDR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760  77 THHRLMSGIEDAGYEIRDTITWHYGSGFPkaldvsksidkqagkkedrevtgkyhnpdGTTRDYdgydtscnvycdrids 156
Cdd:COG0863   79 YISRLIAALRDAGFKLRNEIIWRKPNGVP-----------------------------GPSKRR---------------- 113

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760 157 nehrqttepateqaeqwdgfksaLKPATEFVCVArsplaedtiaenvvthgtgalnidatrvesedggwtRKGPipdisg 236
Cdd:COG0863  114 -----------------------FRNSHEYILWF------------------------------------TKGK------ 128

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760 237 gsyaggnaengalgpsdmtqecddngRYPANVvfdaqqadvldDEVGELGGGSMTRngDVegkeWEndvnegytegrdrs 316
Cdd:COG0863  129 --------------------------KYTFNV-----------DAVKSIEDGRNPS--DV----WD-------------- 151

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760 317 mfvneaaddgvrsygdsggpsryfyTSKASKAERTLdgkidnaHPTVKPIDLMEWLVQLATAEEQIVLDPFAGSGTTCKA 396
Cdd:COG0863  152 -------------------------IPGVTPKERKG-------HPTQKPVELLERLILASSNPGDIVLDPFAGSGTTLVA 199

                        410       420
                 ....*....|....*....|....
gi 383397760 397 AKNKNRQFIGIEQQAKWADVARVR 420
Cdd:COG0863  200 AERLGRRFIGIEIDPEYVEVARRR 223
N6_N4_Mtase pfam01555
DNA methylase; Members of this family are DNA methylases. The family contains both N-4 ...
 22-408 8.14e-23

DNA methylase; Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.


Pssm-ID: 396230 [Multi-domain]  Cd Length: 221  Bit Score: 95.93  E-value: 8.14e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760   22 VHAIVTDPPYGLAFMGRSWDDF-EPKEYQEWCEKWATECLRVLKPGGHLLAF-SGNRTHHRLMSGIEDAG-YEIRDTITW 98
Cdd:pfam01555   1 VDLIVTDPPYNLGKDYGQWDDKdSIEEYLEWLEEWLKEVRRVLKPGGSIFINiGDSNIKSLKALALEILGiFKLLNDIIW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760   99 HYGSGFPKAldvsksidkqagkKEDRevtgkyhnpdgttrdydgydtscnvycdridsnehrqttepateqaeqwdgfks 178
Cdd:pfam01555  81 RKPNGMPNS-------------NGER------------------------------------------------------ 93

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760  179 aLKPATEFVcvarsplaedtiaenvvthgtgalnidatrvesedgGWTRKGPIPdisggsyaggnaengalgpsdmtqec 258
Cdd:pfam01555  94 -FTPAHEYI------------------------------------LWFSKTKKY-------------------------- 110

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760  259 ddngrypanvvfdaqqadvlddevgelgggsMTRNGDVegkewendVNEGYtegRDRSMFVNEAADDGVRSYGDSGGPSR 338
Cdd:pfam01555 111 -------------------------------KTFNYDA--------IKVPY---DEKDKLKKRGSEPNGKPIGDVWDFSR 148

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760  339 YFYTSKASkaertldgKIDNAHPTVKPIDLMEWLVQLATAEEQIVLDPFAGSGTTCKAAKNKNRQFIGIE 408
Cdd:pfam01555 149 VQPSEKES--------GGNGKHPTQKPEALLERLILASTNPGDIVLDPFAGSGTTGAAAKELGRNFIGIE 210
PRK11524 PRK11524
adenine-specific DNA-methyltransferase;
5-102 2.63e-13

adenine-specific DNA-methyltransferase;


Pssm-ID: 183177 [Multi-domain]  Cd Length: 284  Bit Score: 70.14  E-value: 2.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760   5 IYTGDCFEQLPALDENSVHAIVTDPPYGLafmGRSWDDF----EPKEYQEWCEKWATECLRVLKPGGHLLafsgnrthhr 80
Cdd:PRK11524  11 IIHGDALTELKKIPSESVDLIFADPPYNI---GKNFDGLieawKEDLFIDWLYEWIDECHRVLKKQGTMY---------- 77

                         90       100       110
                 ....*....|....*....|....*....|.
gi 383397760  81 LMSGIEDAGY---EIRDTIT------WHYGS 102
Cdd:PRK11524  78 IMNSTENMPFidlYCRKLFTiksrivWSYDS 108
 
Name Accession Description Interval E-value
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
4-420 1.38e-40

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 144.68  E-value: 1.38e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760   4 QIYTGDCFEQLPALDENSVHAIVTDPPYGLAFMGRS-------WDDFEpkEYQEWCEKWATECLRVLKPGGHLLAFSGNR 76
Cdd:COG0863    1 RLICGDCLEVLKELPDESVDLIVTDPPYNLGKKYGLgrreignELSFE--EYLEFLREWLAECYRVLKPGGSLYVNIGDR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760  77 THHRLMSGIEDAGYEIRDTITWHYGSGFPkaldvsksidkqagkkedrevtgkyhnpdGTTRDYdgydtscnvycdrids 156
Cdd:COG0863   79 YISRLIAALRDAGFKLRNEIIWRKPNGVP-----------------------------GPSKRR---------------- 113

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760 157 nehrqttepateqaeqwdgfksaLKPATEFVCVArsplaedtiaenvvthgtgalnidatrvesedggwtRKGPipdisg 236
Cdd:COG0863  114 -----------------------FRNSHEYILWF------------------------------------TKGK------ 128

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760 237 gsyaggnaengalgpsdmtqecddngRYPANVvfdaqqadvldDEVGELGGGSMTRngDVegkeWEndvnegytegrdrs 316
Cdd:COG0863  129 --------------------------KYTFNV-----------DAVKSIEDGRNPS--DV----WD-------------- 151

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760 317 mfvneaaddgvrsygdsggpsryfyTSKASKAERTLdgkidnaHPTVKPIDLMEWLVQLATAEEQIVLDPFAGSGTTCKA 396
Cdd:COG0863  152 -------------------------IPGVTPKERKG-------HPTQKPVELLERLILASSNPGDIVLDPFAGSGTTLVA 199

                        410       420
                 ....*....|....*....|....
gi 383397760 397 AKNKNRQFIGIEQQAKWADVARVR 420
Cdd:COG0863  200 AERLGRRFIGIEIDPEYVEVARRR 223
N6_N4_Mtase pfam01555
DNA methylase; Members of this family are DNA methylases. The family contains both N-4 ...
 22-408 8.14e-23

DNA methylase; Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.


Pssm-ID: 396230 [Multi-domain]  Cd Length: 221  Bit Score: 95.93  E-value: 8.14e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760   22 VHAIVTDPPYGLAFMGRSWDDF-EPKEYQEWCEKWATECLRVLKPGGHLLAF-SGNRTHHRLMSGIEDAG-YEIRDTITW 98
Cdd:pfam01555   1 VDLIVTDPPYNLGKDYGQWDDKdSIEEYLEWLEEWLKEVRRVLKPGGSIFINiGDSNIKSLKALALEILGiFKLLNDIIW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760   99 HYGSGFPKAldvsksidkqagkKEDRevtgkyhnpdgttrdydgydtscnvycdridsnehrqttepateqaeqwdgfks 178
Cdd:pfam01555  81 RKPNGMPNS-------------NGER------------------------------------------------------ 93

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760  179 aLKPATEFVcvarsplaedtiaenvvthgtgalnidatrvesedgGWTRKGPIPdisggsyaggnaengalgpsdmtqec 258
Cdd:pfam01555  94 -FTPAHEYI------------------------------------LWFSKTKKY-------------------------- 110

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760  259 ddngrypanvvfdaqqadvlddevgelgggsMTRNGDVegkewendVNEGYtegRDRSMFVNEAADDGVRSYGDSGGPSR 338
Cdd:pfam01555 111 -------------------------------KTFNYDA--------IKVPY---DEKDKLKKRGSEPNGKPIGDVWDFSR 148

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760  339 YFYTSKASkaertldgKIDNAHPTVKPIDLMEWLVQLATAEEQIVLDPFAGSGTTCKAAKNKNRQFIGIE 408
Cdd:pfam01555 149 VQPSEKES--------GGNGKHPTQKPEALLERLILASTNPGDIVLDPFAGSGTTGAAAKELGRNFIGIE 210
PRK11524 PRK11524
adenine-specific DNA-methyltransferase;
5-102 2.63e-13

adenine-specific DNA-methyltransferase;


Pssm-ID: 183177 [Multi-domain]  Cd Length: 284  Bit Score: 70.14  E-value: 2.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760   5 IYTGDCFEQLPALDENSVHAIVTDPPYGLafmGRSWDDF----EPKEYQEWCEKWATECLRVLKPGGHLLafsgnrthhr 80
Cdd:PRK11524  11 IIHGDALTELKKIPSESVDLIFADPPYNI---GKNFDGLieawKEDLFIDWLYEWIDECHRVLKKQGTMY---------- 77

                         90       100       110
                 ....*....|....*....|....*....|.
gi 383397760  81 LMSGIEDAGY---EIRDTIT------WHYGS 102
Cdd:PRK11524  78 IMNSTENMPFidlYCRKLFTiksrivWSYDS 108
Mod COG2189
Adenine specific DNA methylase Mod [Replication, recombination and repair];
337-409 8.52e-12

Adenine specific DNA methylase Mod [Replication, recombination and repair];


Pssm-ID: 441792 [Multi-domain]  Cd Length: 491  Bit Score: 66.72  E-value: 8.52e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 383397760 337 SRYFYTSKASKAERTLDGkiDNAHPTVKPIDLMEWLVQLATAEEQIVLDPFAGSGTTCKAA------KNKNRQFIGIEQ 409
Cdd:COG2189  280 DDIGTNQNGTKELKELFG--GKVFDTPKPEKLLKRIIEIATNPGDLVLDFFAGSGTTAHAVmklnaeDGGNRRFILVQL 356
PRK13699 PRK13699
putative methylase; Provisional
 360-408 2.86e-11

putative methylase; Provisional


Pssm-ID: 184255  Cd Length: 227  Bit Score: 62.93  E-value: 2.86e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 383397760 360 HPTVKPIDLMEWLVQLATAEEQIVLDPFAGSGTTCKAAKNKNRQFIGIE 408
Cdd:PRK13699 144 HPTEKPVTSLQPLIESFTHPNAIVLDPFAGSGSTCVAALQSGRRYIGIE 192
PRK11524 PRK11524
adenine-specific DNA-methyltransferase;
360-413 3.03e-10

adenine-specific DNA-methyltransferase;


Pssm-ID: 183177 [Multi-domain]  Cd Length: 284  Bit Score: 60.89  E-value: 3.03e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 383397760 360 HPTVKPIDLMEWLVQLATAEEQIVLDPFAGSGTTCKAAKNKNRQFIGIEQQAKW 413
Cdd:PRK11524 189 HPTQKPEALLKRIILASSNPGDIVLDPFAGSFTTGAVAKASGRKFIGIEINSEY 242
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 5-97 3.90e-08

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 52.64  E-value: 3.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760   5 IYTGDcFEQLPALDEnSVHAIVTDPPYGLAFMGRSwddfepKEYQEWCEKWATECLRVLKPGGHlLAFSGNRTHHRLmsg 84
Cdd:COG1041   78 VIRGD-ARDLPLADE-SVDAIVTDPPYGRSSKISG------EELLELYEKALEEAARVLKPGGR-VVIVTPRDIDEL--- 145

                         90
                 ....*....|...
gi 383397760  85 IEDAGYEIRDTIT 97
Cdd:COG1041  146 LEEAGFKVLERHE 158
PRK13699 PRK13699
putative methylase; Provisional
 8-92 2.16e-07

putative methylase; Provisional


Pssm-ID: 184255  Cd Length: 227  Bit Score: 51.37  E-value: 2.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760   8 GDCFEQLPALDENSVHAIVTDPPYGLAFMGRSWDDFEPKEYQEWCEKWATECLRVLKPGGHLLAFSG-NRThHRLMSGIE 86
Cdd:PRK13699   7 GNCIDVMARFPDNAVDFILTDPPYLVGFRDRQGRTIAGDKTDEWLQPACNEMYRVLKKDALMVSFYGwNRV-DRFMAAWK 85


                 ....*.
gi 383397760  87 DAGYEI 92
Cdd:PRK13699  86 NAGFSV 91
COG2521 COG2521
Predicted archaeal methyltransferase [General function prediction only];
4-91 3.00e-06

Predicted archaeal methyltransferase [General function prediction only];


Pssm-ID: 442011 [Multi-domain]  Cd Length: 285  Bit Score: 48.75  E-value: 3.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760   4 QIYTGDCFEQLPALDENSVHAIVTDPP--------YGLAFmgrswddfepkeYQEWCekwateclRVLKPGGHLLAFSGN 75
Cdd:COG2521  186 KIILGDASEVIKTFPDESFDAIIHDPPrfslagelYSLEF------------YRELY--------RVLKPGGRLFHYTGN 245

                         90       100
                 ....*....|....*....|....
gi 383397760  76 ---RTHHR-----LMSGIEDAGYE 91
Cdd:COG2521  246 pgkKKRGRdvprgVAERLRKAGFK 269
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 372-418 1.70e-03

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 39.16  E-value: 1.70e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 383397760 372 LVQLATAEEQ-IVLDPFAGSGTTCKAAKNKNRQFIGIEQQAKWADVAR 418
Cdd:COG1041   18 LVNLAGAKEGdTVLDPFCGTGTILIEAGLLGRRVIGSDIDPKMVEGAR 65
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 8-91 7.04e-03

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 36.90  E-value: 7.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397760   8 GDcFEQLPaLDENSVHAIVtdppygLAFMGRSWDDFEpkeyqewceKWATECLRVLKPGGHLLAFSGNRTHHR-LMSGIE 86
Cdd:COG2226   76 GD-AEDLP-FPDGSFDLVI------SSFVLHHLPDPE---------RALAEIARVLKPGGRLVVVDFSPPDLAeLEELLA 138


                 ....*
gi 383397760  87 DAGYE 91
Cdd:COG2226  139 EAGFE 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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