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Conserved domains on  [gi|383397829|gb|AFH22606|]
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hypothetical protein OSG_eHP30_00255 [environmental Halophage eHP-30]

Protein Classification

DUF2945 domain-containing protein( domain architecture ID 10567668)

DUF2945 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hva1_TUDOR pfam11160
Hypervirulence associated proteins TUDOR domain; Family members include HVA1 ...
 303-349 2.01e-07

Hypervirulence associated proteins TUDOR domain; Family members include HVA1 (hypervirulence-associated protein 1) whose absence is associated with a hypervirulent phenotype in mice. Metabolomics analysis suggests that when HVA1 is absent there is a block in the citric acid cycle, while structural analysis of the Hva1 protein suggests a potential interaction with NADPH. The structural architecture of Hva1 bears similarity with Tudor domains.


:

Pssm-ID: 431691 [Multi-domain]  Cd Length: 59  Bit Score: 47.88  E-value: 2.01e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 383397829  303 GDFVRWNSSGGQAEGQIDRIQTS-GEIDvpdsSFTINASEDDPAALIT 349
Cdd:pfam11160   1 GDKVSWKWGGGTAEGKVVEVLTEeTEAK----GVTVNASEDDPAYEIE 44
Peptidase_S78 super family cl01521
Caudovirus prohead serine protease; Family of Caudovirus prohead serine proteases also found ...
 47-203 2.25e-06

Caudovirus prohead serine protease; Family of Caudovirus prohead serine proteases also found in a number of bacteria possibly as the result of horizontal transfer.


The actual alignment was detected with superfamily member COG3740:

Pssm-ID: 470233  Cd Length: 183  Bit Score: 48.06  E-value: 2.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397829  47 LDNFKKNPIVLYQHqgyggpesNPDDVIASAEVFEEgmgQDKKLIGRAYFEPAevNEKADKIFKKIQQGTLRATSVGFMP 126
Cdd:COG3740   52 LAERGSDVPMLWQH--------DPAKPLGRWDELRE---DDKGLRVEGRLLPD--TPRARDVYALIKAGAIDGLSIGFRV 118

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 383397829 127 IEDEngrigqFGKDDGNGSRTNTDtfyfngQELLEFSIVNIPSNPNAVRNGLGEATRSFTDYPRRAVDNAKKALEIK 203
Cdd:COG3740  119 VKDE------WERDGGTGVRTILE------VDLWEVSVVTFPAYPDARVSARKSALEAAEAEALRLARALRRARALR 183
 
Name Accession Description Interval E-value
Hva1_TUDOR pfam11160
Hypervirulence associated proteins TUDOR domain; Family members include HVA1 ...
 303-349 2.01e-07

Hypervirulence associated proteins TUDOR domain; Family members include HVA1 (hypervirulence-associated protein 1) whose absence is associated with a hypervirulent phenotype in mice. Metabolomics analysis suggests that when HVA1 is absent there is a block in the citric acid cycle, while structural analysis of the Hva1 protein suggests a potential interaction with NADPH. The structural architecture of Hva1 bears similarity with Tudor domains.


Pssm-ID: 431691 [Multi-domain]  Cd Length: 59  Bit Score: 47.88  E-value: 2.01e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 383397829  303 GDFVRWNSSGGQAEGQIDRIQTS-GEIDvpdsSFTINASEDDPAALIT 349
Cdd:pfam11160   1 GDKVSWKWGGGTAEGKVVEVLTEeTEAK----GVTVNASEDDPAYEIE 44
COG3740 COG3740
Phage head maturation protease [Mobilome: prophages, transposons];
47-203 2.25e-06

Phage head maturation protease [Mobilome: prophages, transposons];


Pssm-ID: 442954  Cd Length: 183  Bit Score: 48.06  E-value: 2.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397829  47 LDNFKKNPIVLYQHqgyggpesNPDDVIASAEVFEEgmgQDKKLIGRAYFEPAevNEKADKIFKKIQQGTLRATSVGFMP 126
Cdd:COG3740   52 LAERGSDVPMLWQH--------DPAKPLGRWDELRE---DDKGLRVEGRLLPD--TPRARDVYALIKAGAIDGLSIGFRV 118

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 383397829 127 IEDEngrigqFGKDDGNGSRTNTDtfyfngQELLEFSIVNIPSNPNAVRNGLGEATRSFTDYPRRAVDNAKKALEIK 203
Cdd:COG3740  119 VKDE------WERDGGTGVRTILE------VDLWEVSVVTFPAYPDARVSARKSALEAAEAEALRLARALRRARALR 183
 
Name Accession Description Interval E-value
Hva1_TUDOR pfam11160
Hypervirulence associated proteins TUDOR domain; Family members include HVA1 ...
 303-349 2.01e-07

Hypervirulence associated proteins TUDOR domain; Family members include HVA1 (hypervirulence-associated protein 1) whose absence is associated with a hypervirulent phenotype in mice. Metabolomics analysis suggests that when HVA1 is absent there is a block in the citric acid cycle, while structural analysis of the Hva1 protein suggests a potential interaction with NADPH. The structural architecture of Hva1 bears similarity with Tudor domains.


Pssm-ID: 431691 [Multi-domain]  Cd Length: 59  Bit Score: 47.88  E-value: 2.01e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 383397829  303 GDFVRWNSSGGQAEGQIDRIQTS-GEIDvpdsSFTINASEDDPAALIT 349
Cdd:pfam11160   1 GDKVSWKWGGGTAEGKVVEVLTEeTEAK----GVTVNASEDDPAYEIE 44
COG3740 COG3740
Phage head maturation protease [Mobilome: prophages, transposons];
47-203 2.25e-06

Phage head maturation protease [Mobilome: prophages, transposons];


Pssm-ID: 442954  Cd Length: 183  Bit Score: 48.06  E-value: 2.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383397829  47 LDNFKKNPIVLYQHqgyggpesNPDDVIASAEVFEEgmgQDKKLIGRAYFEPAevNEKADKIFKKIQQGTLRATSVGFMP 126
Cdd:COG3740   52 LAERGSDVPMLWQH--------DPAKPLGRWDELRE---DDKGLRVEGRLLPD--TPRARDVYALIKAGAIDGLSIGFRV 118

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 383397829 127 IEDEngrigqFGKDDGNGSRTNTDtfyfngQELLEFSIVNIPSNPNAVRNGLGEATRSFTDYPRRAVDNAKKALEIK 203
Cdd:COG3740  119 VKDE------WERDGGTGVRTILE------VDLWEVSVVTFPAYPDARVSARKSALEAAEAEALRLARALRRARALR 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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