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Conserved domains on  [gi|396941823|gb|AFN89629|]
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RNA polymerase II, partial [Saccharomyces cerevisiae]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ricin_B_lectin super family cl47023
Ricin-type beta-trefoil lectin domain;
13-770 0e+00

Ricin-type beta-trefoil lectin domain;


The actual alignment was detected with superfamily member PRK08565:

Pssm-ID: 481363 [Multi-domain]  Cd Length: 1103  Bit Score: 851.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823   13 VIQDRETALDFIGRRgTALGIKKEKRIQYAKDILQKEFLPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFG 92
Cdd:PRK08565  253 IAATVEDALDYIGKR-VAIGQPREYRIERAEQILDKYLLPHLGTSPEDRIKKAYFLGQMASKLLELYLGRREPDDKDHYA 331
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823   93 KKRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTVEEAHDFNMKLAINAKTITSGLKYALATGNWGeqkkamSSRAGVSQV 172
Cdd:PRK08565  332 NKRLRLAGDLLAELFRVAFKQLVKDLKYQLEKSYARGRKLDLRAIVRPDIITERIRHALATGNWV------GGRTGVSQL 405
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  173 LNRYTYSSTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLMSCISVGTDPMPIITFLSEWG 252
Cdd:PRK08565  406 LDRTNYLSTLSHLRRVVSPLSRGQPHFEARDLHGTQWGRICPFETPEGPNCGLVKNLALMAQISVGVDEEEVEEILYELG 485
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  253 MEPLEDYVPHQSPDATRVFVNGVWHGVHRNPARLMETLRTLRRKGDINPEVSM--IRDIREKELKIFTDAGRVYRPLFIV 330
Cdd:PRK08565  486 VVPVEEAREEEYISWSRVYLNGRLIGYHPDGEELAEKIRELRRSGKISDEVNVayIETGEINEVYVNCDSGRVRRPLIVV 565
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  331 EDDEslghkeLKVRKGHIAKLmateyqdieggfeDVEEYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPaeaneend 410
Cdd:PRK08565  566 ENGK------PKLTREHVEKL-------------KKGELTFDDLVKMGVIEYLDAEEEENAYVALDPEDLTP-------- 618
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  411 ldvdpakrirvSHhattfTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQ 490
Cdd:PRK08565  619 -----------EH-----THLEIWPPAILGITASIIPYPEHNQSPRNTYQAAMAKQSLGLYAANFRIRTDTRGHLLHYPQ 682
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  491 KPLGTTRAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPqrT 570
Cdd:PRK08565  683 RPLVQTRALEIIGYNDRPAGQNAVVAVLSYTGYNIEDAIIMNKASIERGLARSTFFRTYETEERKYPGGQEDKIEIP--E 760
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  571 NTLRMKHG--TYDKLDDDGLIAPGVRVSGEDVIIGKTTPISPDEEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTTNQ 648
Cdd:PRK08565  761 PNVRGYRGeeYYRKLDEDGIVSPEVEVKGGDVLIGKTSPPRFLEELEELSLGLQERRDTSVTVRHGEKGIVDTVLITESP 840
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  649 DGLKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALS 728
Cdd:PRK08565  841 EGNKLVKVRVRDLRIPELGDKFASRHGQKGVIGMLVPQEDMPFTEDGIVPDLIINPHAIPSRMTVGQLLESIAGKVAALE 920
                         730       740       750       760
                  ....*....|....*....|....*....|....*....|..
gi 396941823  729 GNEGDASPFTDITVEGISKLLREHGYQS*GFEVMYNGHTGKK 770
Cdd:PRK08565  921 GRFVDATPFYGEPEEELRKELLKLGYKPDGTEVMYDGRTGEK 962
 
Name Accession Description Interval E-value
PRK08565 PRK08565
DNA-directed RNA polymerase subunit B; Provisional
13-770 0e+00

DNA-directed RNA polymerase subunit B; Provisional


Pssm-ID: 236291 [Multi-domain]  Cd Length: 1103  Bit Score: 851.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823   13 VIQDRETALDFIGRRgTALGIKKEKRIQYAKDILQKEFLPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFG 92
Cdd:PRK08565  253 IAATVEDALDYIGKR-VAIGQPREYRIERAEQILDKYLLPHLGTSPEDRIKKAYFLGQMASKLLELYLGRREPDDKDHYA 331
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823   93 KKRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTVEEAHDFNMKLAINAKTITSGLKYALATGNWGeqkkamSSRAGVSQV 172
Cdd:PRK08565  332 NKRLRLAGDLLAELFRVAFKQLVKDLKYQLEKSYARGRKLDLRAIVRPDIITERIRHALATGNWV------GGRTGVSQL 405
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  173 LNRYTYSSTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLMSCISVGTDPMPIITFLSEWG 252
Cdd:PRK08565  406 LDRTNYLSTLSHLRRVVSPLSRGQPHFEARDLHGTQWGRICPFETPEGPNCGLVKNLALMAQISVGVDEEEVEEILYELG 485
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  253 MEPLEDYVPHQSPDATRVFVNGVWHGVHRNPARLMETLRTLRRKGDINPEVSM--IRDIREKELKIFTDAGRVYRPLFIV 330
Cdd:PRK08565  486 VVPVEEAREEEYISWSRVYLNGRLIGYHPDGEELAEKIRELRRSGKISDEVNVayIETGEINEVYVNCDSGRVRRPLIVV 565
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  331 EDDEslghkeLKVRKGHIAKLmateyqdieggfeDVEEYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPaeaneend 410
Cdd:PRK08565  566 ENGK------PKLTREHVEKL-------------KKGELTFDDLVKMGVIEYLDAEEEENAYVALDPEDLTP-------- 618
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  411 ldvdpakrirvSHhattfTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQ 490
Cdd:PRK08565  619 -----------EH-----THLEIWPPAILGITASIIPYPEHNQSPRNTYQAAMAKQSLGLYAANFRIRTDTRGHLLHYPQ 682
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  491 KPLGTTRAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPqrT 570
Cdd:PRK08565  683 RPLVQTRALEIIGYNDRPAGQNAVVAVLSYTGYNIEDAIIMNKASIERGLARSTFFRTYETEERKYPGGQEDKIEIP--E 760
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  571 NTLRMKHG--TYDKLDDDGLIAPGVRVSGEDVIIGKTTPISPDEEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTTNQ 648
Cdd:PRK08565  761 PNVRGYRGeeYYRKLDEDGIVSPEVEVKGGDVLIGKTSPPRFLEELEELSLGLQERRDTSVTVRHGEKGIVDTVLITESP 840
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  649 DGLKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALS 728
Cdd:PRK08565  841 EGNKLVKVRVRDLRIPELGDKFASRHGQKGVIGMLVPQEDMPFTEDGIVPDLIINPHAIPSRMTVGQLLESIAGKVAALE 920
                         730       740       750       760
                  ....*....|....*....|....*....|....*....|..
gi 396941823  729 GNEGDASPFTDITVEGISKLLREHGYQS*GFEVMYNGHTGKK 770
Cdd:PRK08565  921 GRFVDATPFYGEPEEELRKELLKLGYKPDGTEVMYDGRTGEK 962
RNA_pol_B_RPB2 cd00653
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. ...
63-770 0e+00

RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase complex contains two related members of this family, in each case they are the two largest subunits.The clamp is a mobile structure that grips DNA during elongation.


Pssm-ID: 238353 [Multi-domain]  Cd Length: 866  Bit Score: 752.48  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  63 RKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTVEEAHDFNMKLAINAKT 142
Cdd:cd00653  208 KRFEDLIYMIRKLILLVLGKGKLDDIDHLGNKRVRLAGELLQNLFRSGLKRLEREVKEKLQKQLSKKKDLTPQLLINSKP 287
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823 143 ITSGLKYALATGNWGeQKKAMSSRAGVSQVLNRYTYSSTLSHLRRTNT-PIGRDGKLAKPRQLHNTHWGLVCPAETPEGQ 221
Cdd:cd00653  288 ITSGIKEFLATGNWG-SKRFLMQRSGLSQVLDRLNPLSELSHKRRISSlGLFRERKGFEVRDLHPSHWGRICPIETPEGE 366
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823 222 ACGLVKNLSLMSCISvgtdpmpiitflsewgmepledyvphqspdatrvfvngvwhgvhrnparlmetlrtlrrkgdinp 301
Cdd:cd00653  367 NCGLVKNLALMARIS----------------------------------------------------------------- 381
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823 302 evsmirdirekelkiftdaGRVYRPLFIVEDDeslghkelkvrkghiaklmateyqdieggfedveeytwssllneglve 381
Cdd:cd00653  382 -------------------GRIERPYRIVEKE------------------------------------------------ 394
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823 382 yidaeeeesiliamqpedlepaeaneendldvdpakrirvshhattFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQS 461
Cdd:cd00653  395 ----------------------------------------------VTHIEISPSQILSVAASLIPFPEHNQSPRNLYQS 428
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823 462 AMGKQAMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLF 541
Cdd:cd00653  429 NMQKQAVGTPALNQQYRMDTKLYLLLYPQKPLVGTGIEEYIAFGELPLGQNAIVAVMSYSGYNFEDAIIINKSSVDRGFF 508
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823 542 RSLFFRSYMDQEKKYGMSITETFekpqRTNTLRMKHGTYDKLDDDGLIAPGVRVSGEDVIIGKTTPISPDEEELGQRTAY 621
Cdd:cd00653  509 RSIHYKKYEIELRKTKNGPEEIT----RGDIPNVSEEKLKNLDEDGIIRPGARVEPGDILVGKITPKGETESTPIFGEKA 584
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823 622 HSKRDASTPLRSTENGIVDQVLVTT---NQDGLKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVP 698
Cdd:cd00653  585 RDVRDTSLKYPGGEKGIVDDVKIFSrelNDGGNKLVKVYIRQKRKPQIGDKFASRHGQKGVISKILPQEDMPFTEDGIPP 664
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 396941823 699 DLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISKLLREHGYQS*GFEVMYNGHTGKK 770
Cdd:cd00653  665 DIILNPHGFPSRMTIGQLLESLLGKAGALLGKFGDATPFDGAEEEDISELLGEAGLNYYGKEVLYDGRTGEP 736
rpoB_arch TIGR03670
DNA-directed RNA polymerase subunit B; This model represents the archaeal version of ...
270-770 0e+00

DNA-directed RNA polymerase subunit B; This model represents the archaeal version of DNA-directed RNA polymerase subunit B (rpoB) and is observed in all archaeal genomes.


Pssm-ID: 274713 [Multi-domain]  Cd Length: 599  Bit Score: 572.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  270 VFVNGVWHGVHRNPARLMETLRTLRRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVEDDEslghkeLKVRKGHIA 349
Cdd:TIGR03670   1 VYLNGRLIGYHDDPEELVEEVRKLRRSGKLSQEVNVAYYEETNEVYINCDAGRIRRPLIVVENGK------PKLTREHVE 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  350 KLMateyqdiEGgfedveEYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPaeaneendldvdpakrirvSHhattfT 429
Cdd:TIGR03670  75 KLK-------EG------ELTWDDLVKQGVIEYLDAEEEENAYIALDPEELTP-------------------EH-----T 117
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  430 HCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPA 509
Cdd:TIGR03670 118 HLEIDPSAILGIIASTIPYPEHNQSPRNTMGAAMAKQSLGLYAANYRIRLDTRGHLLHYPQKPLVKTRVLELIGYDDRPA 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  510 GQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPqrTNTLRMKHG--TYDKLDDDG 587
Cdd:TIGR03670 198 GQNFVVAVMSYEGYNIEDALIMNKASIERGLARSTFFRTYEAEERRYPGGQEDRFEIP--EPDVRGYRGeeAYKHLDEDG 275
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  588 LIAPGVRVSGEDVIIGKTTPISPDEEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTTNQDGLKFVKVRVRTTKIPQIG 667
Cdd:TIGR03670 276 IVYPEVEVKGGDVLIGKTSPPRFLEELREFGLVTERRRDTSVTVRHGEKGIVDKVIITETEEGNKLVKVRVRDLRIPELG 355
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  668 DKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISK 747
Cdd:TIGR03670 356 DKFASRHGQKGVIGMIVPQEDMPFTEDGIVPDLIINPHAIPSRMTVGQLLEMIAGKVAALEGRRVDGTPFEGEPEEELRK 435
                         490       500
                  ....*....|....*....|...
gi 396941823  748 LLREHGYQS*GFEVMYNGHTGKK 770
Cdd:TIGR03670 436 ELLKLGFKPDGKEVMYDGITGEK 458
RNA_pol_Rpb2_6 pfam00562
RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of ...
443-770 2.07e-151

RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion. This domain is also involved in binding to Rpb1 and Rpb3. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).


Pssm-ID: 459854 [Multi-domain]  Cd Length: 371  Bit Score: 446.21  E-value: 2.07e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  443 ASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYSG 522
Cdd:pfam00562   2 ASLIPFVDHNQSPRNTYQCAMGKQAMGIYTLNKFYRSDQNTYVLCYPQKPLVKTGAVEAGGFGELPLGQNAIVAVMSYTG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  523 YNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMsITETFEKPqrtntLRMKHGTYDKLDDDGLIAPGVRVSGEDVII 602
Cdd:pfam00562  82 YNQEDAIIINKSSVDRGFFTSIHIKEIEARKTKLGP-IEEITRDI-----PNVSEEALKKLDEDGIVRVGAEVKPGDILV 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  603 GKTTPISPDEE--ELGQRTAYHsKRDASTPLRSTENGIVDQVLV-TTNQDGLKFVKVRVRTTKIPQIGDKFASRHGQKGT 679
Cdd:pfam00562 156 GKVGPTELTKLlrAIFGEKARD-VKDTSLKVPPGEEGVVDDVIVfELPPGGIKMVKVYIRQKRKPEVGDKFASRHGQKGV 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  680 IGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFT--DITVEGISKLLREHGYQS* 757
Cdd:pfam00562 235 VSRILPQEDMPFTEDGIPPDIILNPHGVPSRMTIGQLLETHLGKAAALLGVFVDATPFDgaSTEVEDIGELLEKAGYNYY 314
                         330
                  ....*....|...
gi 396941823  758 GFEVMYNGHTGKK 770
Cdd:pfam00562 315 GKEVLYDGRTGEP 327
RpoB COG0085
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA ...
14-770 1.78e-148

DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA polymerase, beta subunit/140 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439855 [Multi-domain]  Cd Length: 1001  Bit Score: 459.96  E-value: 1.78e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823   14 IQDRETALDFIGRRgtaLGIKKEKRIQYAKDILQKEF-------LPHI---------TQLEGFESR--KAFFLGYMINRL 75
Cdd:COG0085   216 TKTQEEALLEIYRK---LRPGEPPTIERAEQLLDNLFfdpkrydLAHVgrykinkklGLDVPPEDRvlTAEDIVATIKYL 292
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823   76 LLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIfRYmQRTVEEAHDFNMKLAINAKTITSGLKYALATGn 155
Cdd:COG0085   293 LELHLGEREPDDIDHLGNRRVRLVGELLQNQFRVGLSRMERVV-RE-RMTTQDVEAITPQSLINIRPVVAAIKEFFGSS- 369
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  156 wgeqkkamssraGVSQVLNRYTYSSTLSHLRRTNT----PIGRDgklaKP----RQLHNTHWGLVCPAETPEGQACGLVK 227
Cdd:COG0085   370 ------------QLSQFMDQTNPLSELTHKRRLSAlgpgGLSRE----RAgfevRDVHPSHYGRMCPIETPEGPNIGLIG 433
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  228 NLSLMscisvgtdpmpiitflsewgmepledyvphqspdatrvfvngvwhgvhrnparlmetlrtlrrkGDINPEvsmir 307
Cdd:COG0085   434 SLALY----------------------------------------------------------------ARVNEY----- 444
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  308 direkelkiftdaGRVYRPLFIVEDdeslGhkelKVRKGhiaklmateyqdieggfedveeytwssllneglVEYIDAEE 387
Cdd:COG0085   445 -------------GFIETPYRKVEN----G----KVTDE---------------------------------IEYLTADE 470
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  388 EESILIAMQPEDLePAEANEENDLDVDPAKRIRVSHHATTFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQA 467
Cdd:COG0085   471 EENYYIAQANAPL-DEDGNFLEERVLVRYRGEEVLVPPEEVDYMDVSPKQIVSVATSLIPFLEHDDANRALMGANMQRQA 549
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  468 MGVFLTNynvrmdtmANILYYP--------------QKPLgtTRAMEYLK------------FRELPAGQNAIVAIACYS 521
Cdd:COG0085   550 VPLLRPE--------APLLHYPlqkfqrsnqgtcinQRPI--VRVGDRVEkgdvladgpatdNGELALGQNLLVAFMPWE 619
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  522 GYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKY--GMSITeTFEKPqrtntlrmKHG--TYDKLDDDGLIAPGVRVSG 597
Cdd:COG0085   620 GYNYEDAIIISERLVKDDVLTSIHIEEYEIEARDTklGPEEI-TRDIP--------NVSeeALRNLDEDGIIRIGAEVKG 690
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  598 EDVIIGKTTP-----ISPDEEELgqRTAYHSK----RDASTPLRSTENGIVDQVLVTTNQDG-------LKFVKVRVRTT 661
Cdd:COG0085   691 GDILVGKVTPkgeteLTPEERLL--RAIFGEKarevRDTSLRVPHGEKGKVIDVKVFSREEGdelppgvNKLVRVYVAQK 768
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  662 KIPQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDIT 741
Cdd:COG0085   769 RKIEVGDKLAGRHGNKGVISRILPQEDMPFLEDGTPVDIVLNPLGVPSRMNVGQVLETHLGWAAALLGRRVATPVFDGAP 848
                         810       820
                  ....*....|....*....|....*....
gi 396941823  742 VEGISKLLREHGYQS*GFEVMYNGHTGKK 770
Cdd:COG0085   849 EEEIRELLEKAGLPPDGKEVLYDGRTGEP 877
 
Name Accession Description Interval E-value
PRK08565 PRK08565
DNA-directed RNA polymerase subunit B; Provisional
13-770 0e+00

DNA-directed RNA polymerase subunit B; Provisional


Pssm-ID: 236291 [Multi-domain]  Cd Length: 1103  Bit Score: 851.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823   13 VIQDRETALDFIGRRgTALGIKKEKRIQYAKDILQKEFLPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFG 92
Cdd:PRK08565  253 IAATVEDALDYIGKR-VAIGQPREYRIERAEQILDKYLLPHLGTSPEDRIKKAYFLGQMASKLLELYLGRREPDDKDHYA 331
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823   93 KKRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTVEEAHDFNMKLAINAKTITSGLKYALATGNWGeqkkamSSRAGVSQV 172
Cdd:PRK08565  332 NKRLRLAGDLLAELFRVAFKQLVKDLKYQLEKSYARGRKLDLRAIVRPDIITERIRHALATGNWV------GGRTGVSQL 405
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  173 LNRYTYSSTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLMSCISVGTDPMPIITFLSEWG 252
Cdd:PRK08565  406 LDRTNYLSTLSHLRRVVSPLSRGQPHFEARDLHGTQWGRICPFETPEGPNCGLVKNLALMAQISVGVDEEEVEEILYELG 485
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  253 MEPLEDYVPHQSPDATRVFVNGVWHGVHRNPARLMETLRTLRRKGDINPEVSM--IRDIREKELKIFTDAGRVYRPLFIV 330
Cdd:PRK08565  486 VVPVEEAREEEYISWSRVYLNGRLIGYHPDGEELAEKIRELRRSGKISDEVNVayIETGEINEVYVNCDSGRVRRPLIVV 565
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  331 EDDEslghkeLKVRKGHIAKLmateyqdieggfeDVEEYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPaeaneend 410
Cdd:PRK08565  566 ENGK------PKLTREHVEKL-------------KKGELTFDDLVKMGVIEYLDAEEEENAYVALDPEDLTP-------- 618
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  411 ldvdpakrirvSHhattfTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQ 490
Cdd:PRK08565  619 -----------EH-----THLEIWPPAILGITASIIPYPEHNQSPRNTYQAAMAKQSLGLYAANFRIRTDTRGHLLHYPQ 682
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  491 KPLGTTRAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPqrT 570
Cdd:PRK08565  683 RPLVQTRALEIIGYNDRPAGQNAVVAVLSYTGYNIEDAIIMNKASIERGLARSTFFRTYETEERKYPGGQEDKIEIP--E 760
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  571 NTLRMKHG--TYDKLDDDGLIAPGVRVSGEDVIIGKTTPISPDEEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTTNQ 648
Cdd:PRK08565  761 PNVRGYRGeeYYRKLDEDGIVSPEVEVKGGDVLIGKTSPPRFLEELEELSLGLQERRDTSVTVRHGEKGIVDTVLITESP 840
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  649 DGLKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALS 728
Cdd:PRK08565  841 EGNKLVKVRVRDLRIPELGDKFASRHGQKGVIGMLVPQEDMPFTEDGIVPDLIINPHAIPSRMTVGQLLESIAGKVAALE 920
                         730       740       750       760
                  ....*....|....*....|....*....|....*....|..
gi 396941823  729 GNEGDASPFTDITVEGISKLLREHGYQS*GFEVMYNGHTGKK 770
Cdd:PRK08565  921 GRFVDATPFYGEPEEELRKELLKLGYKPDGTEVMYDGRTGEK 962
RNA_pol_B_RPB2 cd00653
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. ...
63-770 0e+00

RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase complex contains two related members of this family, in each case they are the two largest subunits.The clamp is a mobile structure that grips DNA during elongation.


Pssm-ID: 238353 [Multi-domain]  Cd Length: 866  Bit Score: 752.48  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  63 RKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTVEEAHDFNMKLAINAKT 142
Cdd:cd00653  208 KRFEDLIYMIRKLILLVLGKGKLDDIDHLGNKRVRLAGELLQNLFRSGLKRLEREVKEKLQKQLSKKKDLTPQLLINSKP 287
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823 143 ITSGLKYALATGNWGeQKKAMSSRAGVSQVLNRYTYSSTLSHLRRTNT-PIGRDGKLAKPRQLHNTHWGLVCPAETPEGQ 221
Cdd:cd00653  288 ITSGIKEFLATGNWG-SKRFLMQRSGLSQVLDRLNPLSELSHKRRISSlGLFRERKGFEVRDLHPSHWGRICPIETPEGE 366
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823 222 ACGLVKNLSLMSCISvgtdpmpiitflsewgmepledyvphqspdatrvfvngvwhgvhrnparlmetlrtlrrkgdinp 301
Cdd:cd00653  367 NCGLVKNLALMARIS----------------------------------------------------------------- 381
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823 302 evsmirdirekelkiftdaGRVYRPLFIVEDDeslghkelkvrkghiaklmateyqdieggfedveeytwssllneglve 381
Cdd:cd00653  382 -------------------GRIERPYRIVEKE------------------------------------------------ 394
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823 382 yidaeeeesiliamqpedlepaeaneendldvdpakrirvshhattFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQS 461
Cdd:cd00653  395 ----------------------------------------------VTHIEISPSQILSVAASLIPFPEHNQSPRNLYQS 428
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823 462 AMGKQAMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLF 541
Cdd:cd00653  429 NMQKQAVGTPALNQQYRMDTKLYLLLYPQKPLVGTGIEEYIAFGELPLGQNAIVAVMSYSGYNFEDAIIINKSSVDRGFF 508
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823 542 RSLFFRSYMDQEKKYGMSITETFekpqRTNTLRMKHGTYDKLDDDGLIAPGVRVSGEDVIIGKTTPISPDEEELGQRTAY 621
Cdd:cd00653  509 RSIHYKKYEIELRKTKNGPEEIT----RGDIPNVSEEKLKNLDEDGIIRPGARVEPGDILVGKITPKGETESTPIFGEKA 584
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823 622 HSKRDASTPLRSTENGIVDQVLVTT---NQDGLKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVP 698
Cdd:cd00653  585 RDVRDTSLKYPGGEKGIVDDVKIFSrelNDGGNKLVKVYIRQKRKPQIGDKFASRHGQKGVISKILPQEDMPFTEDGIPP 664
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 396941823 699 DLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISKLLREHGYQS*GFEVMYNGHTGKK 770
Cdd:cd00653  665 DIILNPHGFPSRMTIGQLLESLLGKAGALLGKFGDATPFDGAEEEDISELLGEAGLNYYGKEVLYDGRTGEP 736
rpoB_arch TIGR03670
DNA-directed RNA polymerase subunit B; This model represents the archaeal version of ...
270-770 0e+00

DNA-directed RNA polymerase subunit B; This model represents the archaeal version of DNA-directed RNA polymerase subunit B (rpoB) and is observed in all archaeal genomes.


Pssm-ID: 274713 [Multi-domain]  Cd Length: 599  Bit Score: 572.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  270 VFVNGVWHGVHRNPARLMETLRTLRRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVEDDEslghkeLKVRKGHIA 349
Cdd:TIGR03670   1 VYLNGRLIGYHDDPEELVEEVRKLRRSGKLSQEVNVAYYEETNEVYINCDAGRIRRPLIVVENGK------PKLTREHVE 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  350 KLMateyqdiEGgfedveEYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPaeaneendldvdpakrirvSHhattfT 429
Cdd:TIGR03670  75 KLK-------EG------ELTWDDLVKQGVIEYLDAEEEENAYIALDPEELTP-------------------EH-----T 117
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  430 HCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPA 509
Cdd:TIGR03670 118 HLEIDPSAILGIIASTIPYPEHNQSPRNTMGAAMAKQSLGLYAANYRIRLDTRGHLLHYPQKPLVKTRVLELIGYDDRPA 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  510 GQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPqrTNTLRMKHG--TYDKLDDDG 587
Cdd:TIGR03670 198 GQNFVVAVMSYEGYNIEDALIMNKASIERGLARSTFFRTYEAEERRYPGGQEDRFEIP--EPDVRGYRGeeAYKHLDEDG 275
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  588 LIAPGVRVSGEDVIIGKTTPISPDEEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTTNQDGLKFVKVRVRTTKIPQIG 667
Cdd:TIGR03670 276 IVYPEVEVKGGDVLIGKTSPPRFLEELREFGLVTERRRDTSVTVRHGEKGIVDKVIITETEEGNKLVKVRVRDLRIPELG 355
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  668 DKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISK 747
Cdd:TIGR03670 356 DKFASRHGQKGVIGMIVPQEDMPFTEDGIVPDLIINPHAIPSRMTVGQLLEMIAGKVAALEGRRVDGTPFEGEPEEELRK 435
                         490       500
                  ....*....|....*....|...
gi 396941823  748 LLREHGYQS*GFEVMYNGHTGKK 770
Cdd:TIGR03670 436 ELLKLGFKPDGKEVMYDGITGEK 458
PRK07225 PRK07225
DNA-directed RNA polymerase subunit B'; Validated
268-770 0e+00

DNA-directed RNA polymerase subunit B'; Validated


Pssm-ID: 235972 [Multi-domain]  Cd Length: 605  Bit Score: 538.78  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823 268 TRVFVNGVWHGVHRNPARLMETLRTLRRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVEDDESlghkelKVRKGH 347
Cdd:PRK07225   5 AKVYVNGKLIGTHDDPEELVEEIREARRSGEISEEVNVSYKEETNEVIINTDAGRARRPLIVVENGEP------LLTEEH 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823 348 IAKLmateyqdiEGGfedveEYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPAeaneendldvdpakrirvshHatt 427
Cdd:PRK07225  79 IEKL--------KNG-----ELTFDDLVKQGVIEYLDAEEEENAYIAVYEEDLTEE--------------------H--- 122
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823 428 fTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFREL 507
Cdd:PRK07225 123 -THLEIDPSLILGIGAGMIPYPEHNASPRITMGAGMIKQSLGLPAANYKLRPDTRGHLLHYPQVPLVKTQTQEIIGFDER 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823 508 PAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPQRTntLRMKHG--TYDKLDD 585
Cdd:PRK07225 202 PAGQNFVVAVMSYEGYNIEDALIMNKASIERGLGRSHFFRTYEGEERRYPGGQEDRFEIPDKD--VRGYRGeeAYRHLDE 279
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823 586 DGLIAPGVRVSGEDVIIGKTTPISPDEEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTTNQDGLKFVKVRVRTTKIPQ 665
Cdd:PRK07225 280 DGLVNPETEVKEGDVLIGKTSPPRFLEEPDDFGISPEKRRETSVTMRSGEEGIVDTVILTETEEGSRLVKVRVRDLRIPE 359
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823 666 IGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVEGI 745
Cdd:PRK07225 360 LGDKFASRHGQKGVIGLIVPQEDMPFTESGVVPDLIINPHAIPSRMTVGHVLEMIGGKVGSLEGRRVDGTAFSGEDEEDL 439
                        490       500
                 ....*....|....*....|....*
gi 396941823 746 SKLLREHGYQS*GFEVMYNGHTGKK 770
Cdd:PRK07225 440 REALEKLGFEHTGKEVMYDGITGEK 464
RNA_pol_Rpb2_6 pfam00562
RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of ...
443-770 2.07e-151

RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion. This domain is also involved in binding to Rpb1 and Rpb3. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).


Pssm-ID: 459854 [Multi-domain]  Cd Length: 371  Bit Score: 446.21  E-value: 2.07e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  443 ASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYSG 522
Cdd:pfam00562   2 ASLIPFVDHNQSPRNTYQCAMGKQAMGIYTLNKFYRSDQNTYVLCYPQKPLVKTGAVEAGGFGELPLGQNAIVAVMSYTG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  523 YNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMsITETFEKPqrtntLRMKHGTYDKLDDDGLIAPGVRVSGEDVII 602
Cdd:pfam00562  82 YNQEDAIIINKSSVDRGFFTSIHIKEIEARKTKLGP-IEEITRDI-----PNVSEEALKKLDEDGIVRVGAEVKPGDILV 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  603 GKTTPISPDEE--ELGQRTAYHsKRDASTPLRSTENGIVDQVLV-TTNQDGLKFVKVRVRTTKIPQIGDKFASRHGQKGT 679
Cdd:pfam00562 156 GKVGPTELTKLlrAIFGEKARD-VKDTSLKVPPGEEGVVDDVIVfELPPGGIKMVKVYIRQKRKPEVGDKFASRHGQKGV 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  680 IGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFT--DITVEGISKLLREHGYQS* 757
Cdd:pfam00562 235 VSRILPQEDMPFTEDGIPPDIILNPHGVPSRMTIGQLLETHLGKAAALLGVFVDATPFDgaSTEVEDIGELLEKAGYNYY 314
                         330
                  ....*....|...
gi 396941823  758 GFEVMYNGHTGKK 770
Cdd:pfam00562 315 GKEVLYDGRTGEP 327
RpoB COG0085
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA ...
14-770 1.78e-148

DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA polymerase, beta subunit/140 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439855 [Multi-domain]  Cd Length: 1001  Bit Score: 459.96  E-value: 1.78e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823   14 IQDRETALDFIGRRgtaLGIKKEKRIQYAKDILQKEF-------LPHI---------TQLEGFESR--KAFFLGYMINRL 75
Cdd:COG0085   216 TKTQEEALLEIYRK---LRPGEPPTIERAEQLLDNLFfdpkrydLAHVgrykinkklGLDVPPEDRvlTAEDIVATIKYL 292
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823   76 LLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIfRYmQRTVEEAHDFNMKLAINAKTITSGLKYALATGn 155
Cdd:COG0085   293 LELHLGEREPDDIDHLGNRRVRLVGELLQNQFRVGLSRMERVV-RE-RMTTQDVEAITPQSLINIRPVVAAIKEFFGSS- 369
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  156 wgeqkkamssraGVSQVLNRYTYSSTLSHLRRTNT----PIGRDgklaKP----RQLHNTHWGLVCPAETPEGQACGLVK 227
Cdd:COG0085   370 ------------QLSQFMDQTNPLSELTHKRRLSAlgpgGLSRE----RAgfevRDVHPSHYGRMCPIETPEGPNIGLIG 433
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  228 NLSLMscisvgtdpmpiitflsewgmepledyvphqspdatrvfvngvwhgvhrnparlmetlrtlrrkGDINPEvsmir 307
Cdd:COG0085   434 SLALY----------------------------------------------------------------ARVNEY----- 444
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  308 direkelkiftdaGRVYRPLFIVEDdeslGhkelKVRKGhiaklmateyqdieggfedveeytwssllneglVEYIDAEE 387
Cdd:COG0085   445 -------------GFIETPYRKVEN----G----KVTDE---------------------------------IEYLTADE 470
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  388 EESILIAMQPEDLePAEANEENDLDVDPAKRIRVSHHATTFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQA 467
Cdd:COG0085   471 EENYYIAQANAPL-DEDGNFLEERVLVRYRGEEVLVPPEEVDYMDVSPKQIVSVATSLIPFLEHDDANRALMGANMQRQA 549
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  468 MGVFLTNynvrmdtmANILYYP--------------QKPLgtTRAMEYLK------------FRELPAGQNAIVAIACYS 521
Cdd:COG0085   550 VPLLRPE--------APLLHYPlqkfqrsnqgtcinQRPI--VRVGDRVEkgdvladgpatdNGELALGQNLLVAFMPWE 619
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  522 GYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKY--GMSITeTFEKPqrtntlrmKHG--TYDKLDDDGLIAPGVRVSG 597
Cdd:COG0085   620 GYNYEDAIIISERLVKDDVLTSIHIEEYEIEARDTklGPEEI-TRDIP--------NVSeeALRNLDEDGIIRIGAEVKG 690
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  598 EDVIIGKTTP-----ISPDEEELgqRTAYHSK----RDASTPLRSTENGIVDQVLVTTNQDG-------LKFVKVRVRTT 661
Cdd:COG0085   691 GDILVGKVTPkgeteLTPEERLL--RAIFGEKarevRDTSLRVPHGEKGKVIDVKVFSREEGdelppgvNKLVRVYVAQK 768
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  662 KIPQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDIT 741
Cdd:COG0085   769 RKIEVGDKLAGRHGNKGVISRILPQEDMPFLEDGTPVDIVLNPLGVPSRMNVGQVLETHLGWAAALLGRRVATPVFDGAP 848
                         810       820
                  ....*....|....*....|....*....
gi 396941823  742 VEGISKLLREHGYQS*GFEVMYNGHTGKK 770
Cdd:COG0085   849 EEEIRELLEKAGLPPDGKEVLYDGRTGEP 877
PRK09606 PRK09606
DNA-directed RNA polymerase subunit B''; Validated
14-256 1.07e-64

DNA-directed RNA polymerase subunit B''; Validated


Pssm-ID: 236587 [Multi-domain]  Cd Length: 494  Bit Score: 223.67  E-value: 1.07e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  14 IQDRETALDFIGRRGtALGIKKEKRIQYAKDILQKEFLPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFGK 93
Cdd:PRK09606 257 VDTQEEALEYIGKRV-APGQTKEYRIKRAEYVIDRYLLPHLGVEPEVRRAKAHYLGRMAEACFELALGRREEDDKDHYAN 335
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  94 KRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTVEEAHDFNMKLAINAKTITSGLKYALATGNWgeqkkaMSSRAGVSQVL 173
Cdd:PRK09606 336 KRLKLAGDLMEDLFRVAFNRLARDVKYQLERANMRNRELSIKTAVRSDVLTERLEHAMATGNW------VGGRTGVSQLL 409
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823 174 NRYTYSSTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLMSCISVGTDPMPIITFLSEWGM 253
Cdd:PRK09606 410 DRTDYMATLSHLRRVVSPLSRSQPHFEARDLHPTQWGRICPSETPEGPNCGLVKNFAQMVEISTGEDEEEVKEILKELGV 489

                 ...
gi 396941823 254 EPL 256
Cdd:PRK09606 490 EPE 492
RNA_pol_Rpb2_1 pfam04563
RNA polymerase beta subunit; RNA polymerases catalyze the DNA dependent polymerization of RNA. ...
1-145 8.96e-61

RNA polymerase beta subunit; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the protrusion domain. The other lobe (pfam04561) is nested within this domain.


Pssm-ID: 367994 [Multi-domain]  Cd Length: 396  Bit Score: 210.31  E-value: 8.96e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823    1 LEMLKPCVEDGFVI--QDRETALDFIGRRGTA---LGIKKEKRIQYAKDILQKEFLPHITQLEGFESRKAFFLGYMINRL 75
Cdd:pfam04563 247 QEELLPSLEEGFKIriQTQEQALDYIGGRGRAifrMGRPREPRIKYAEEILQKEVLPHLGTYELDETKKAYFIGYMIRRL 326
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823   76 LLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTVEEAHDFNMKLAINAKTITS 145
Cdd:pfam04563 327 LLLALGRREVDDRDHLGNKRLRLAGPLLASLFRVLFKKLVRDVRERLQKVLGSPDDLMLQLLVNAKPITS 396
rpoB TIGR02013
DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit ...
86-770 1.21e-42

DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit of Bacterial RNA polymerase. The core enzyme consists of two alpha chains, one beta chain, and one beta' subunit. [Transcription, DNA-dependent RNA polymerase]


Pssm-ID: 273928 [Multi-domain]  Cd Length: 1065  Bit Score: 167.53  E-value: 1.21e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823    86 DDRDHFGKKRLDLAGPLLAQLFKTLFKKltkdifryMQRTVEE---AHDFNmKLA----INAKTITSGLKYALATGNwge 158
Cdd:TIGR02013  319 DDIDHLGNRRIRSVGELLQNQFRVGLAR--------MERIVRErmsTQDTD-TLTpqdlINAKPISAAIKEFFGSSQ--- 386
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823   159 qkkamssragVSQVLNRYTYSSTLSHLRRTNT--PIG--RDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSlmsc 234
Cdd:TIGR02013  387 ----------LSQFMDQTNPLAELTHKRRLSAlgPGGltRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLS---- 452
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823   235 isvgtdpmpiiTFlsewgmepledyvphqspdaTRVfvngvwhgvhrNPARLMETlrtlrrkgdinPevsmirdirekel 314
Cdd:TIGR02013  453 -----------TY--------------------ARV-----------NEYGFIET-----------P------------- 466
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823   315 kiftdagrvYRplfiveddeslghkelKVRKGhiaklmateyqdiEGGFEDVeeytwssllneglVEYIDAEEEESILIA 394
Cdd:TIGR02013  467 ---------YR----------------KVKDG-------------KVVVTDE-------------IDYLTADEEDNYVIA 495
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823   395 mqpedlePAEAN-EENDLDVDPAKRIRVSHHATTF-----THCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAM 468
Cdd:TIGR02013  496 -------QANAPlDENGRFVEDLVVARYRGEITLVspdqvDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAV 568
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823   469 -------------------------------GV---------FLTNYNVRMDTMANILYYP--------------QKPL- 493
Cdd:TIGR02013  569 pllrseaplvgtgmeakvardsgavivakrgGVveyvdakriVIRYDEDEEEPDGGIDIYRllkyqrsnqdtcinQRPIv 648
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823   494 --------GTTRAMEYLKFR-ELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSY--MDQEKKYGMS-IT 561
Cdd:TIGR02013  649 svgdrveaGDVLADGPSTDLgELALGRNVLVAFMPWNGYNYEDAILISERLVKDDVFTSIHIEEYevEARDTKLGPEeIT 728
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823   562 EtfEKPQrtntlrMKHGTYDKLDDDGLIAPGVRVSGEDVIIGKTTPIS----PDEEELgQRTAYHSK----RDASTPLRS 633
Cdd:TIGR02013  729 R--DIPN------VSEEALRNLDENGIVRIGAEVKAGDILVGKVTPKGetelTPEEKL-LRAIFGEKardvRDTSLRVPP 799
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823   634 TENGIVDQVLVTTNQDG-------LKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHA 706
Cdd:TIGR02013  800 GVEGTVIDVKVFSREQGdelppgvNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSKILPIEDMPFLEDGTPVDIVLNPLG 879
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 396941823   707 IPSRMTVAHLIECLLSKVAALSGNEGD--ASP-FTDITVEGISKLLREHGYQS*GFEVMYNGHTGKK 770
Cdd:TIGR02013  880 VPSRMNIGQILETHLGWAGKRLGRKGVpiATPvFDGASEEEIKEYLEKAGLPRDGKVRLYDGRTGEQ 946
RNA_pol_Rpb2_4 pfam04566
RNA polymerase Rpb2, domain 4; RNA polymerases catalyze the DNA dependent polymerization of ...
270-331 2.85e-32

RNA polymerase Rpb2, domain 4; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 4, is also known as the external 2 domain.


Pssm-ID: 428012 [Multi-domain]  Cd Length: 62  Bit Score: 119.01  E-value: 2.85e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 396941823  270 VFVNGVWHGVHRNPARLMETLRTLRRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVE 331
Cdd:pfam04566   1 VFLNGNLIGVHRDPEELVETLRKLRRSGKISEEVSIVRDIREKEVRINTDGGRVCRPLIIVE 62
RNA_pol_Rpb2_3 pfam04565
RNA polymerase Rpb2, domain 3; RNA polymerases catalyze the DNA dependent polymerization of ...
171-233 1.36e-29

RNA polymerase Rpb2, domain 3; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 3, s also known as the fork domain and is proximal to catalytic site.


Pssm-ID: 428011 [Multi-domain]  Cd Length: 67  Bit Score: 111.46  E-value: 1.36e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 396941823  171 QVLNRYTYSSTLSHLRRTNTPIG---RDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLMS 233
Cdd:pfam04565   1 QVLDRTNYLSTLSHLRRVNSPRGglfREMKTTEVRDLHPSHWGRICPVETPEGPNCGLVKHLALYA 66
rpoB CHL00207
RNA polymerase beta subunit; Provisional
72-721 2.33e-29

RNA polymerase beta subunit; Provisional


Pssm-ID: 214397 [Multi-domain]  Cd Length: 1077  Bit Score: 125.59  E-value: 2.33e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823   72 INRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLF----KTLFKKLTKDIFRYMQRTVEeahDFNMklaINAKTITSGL 147
Cdd:CHL00207  284 IDKLINLKINKGNFDDIDHLKNRRVRSVGELLQNQFriglKRLERILRNRMTICDIDSLS---KFNL---INPKPLIALI 357
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  148 KYALAtgnwgeqkkamSSRagVSQVLNRYTYSSTLSHLRRTNT--PIGRDgKLAKP---RQLHNTHWGLVCPAETPEGQA 222
Cdd:CHL00207  358 REFFG-----------SSQ--LSQYMDQTNPLSELTHKRRISIlgPGGLD-KDRISfavRDIHPSHYGRICPIETPEGPN 423
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  223 CGLVKnlSLMSCISVGTDPMPIITFLsewgmepledyvphqspdatRVFVNGVWhgVHRNPARLMETLRTLRRkgdINPE 302
Cdd:CHL00207  424 CGLIG--SLATNARINKFGFIETPFY--------------------KVINGKVK--KFGNPIYLTADSEDLYR---IAPN 476
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  303 vsmirDIREKELKIFTDagrvyrplfiveddeslghKELKVRKGHIAKLmateyqdieggfedveeytwssllneglvey 382
Cdd:CHL00207  477 -----DINLNKNNYFKK-------------------NIIPVRYKQEFKT------------------------------- 501
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  383 IDAEEEESILIAmqpedlepaeaneendldvdpakrirvshhattfthceihPSMILGVAASIIPFPDHNQSPRNTYQSA 462
Cdd:CHL00207  502 VNPSKVDFIAIS----------------------------------------PIQVFSIAESLIPFLEHNDANRALMGSN 541
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  463 MGKQAMG---------------------------------VFLTNYNVRMDTMAN--ILYYPQK-------------PL- 493
Cdd:CHL00207  542 MQRQAVPllypekpivgtgyekqialdsgmtiisltegivVSVSAYKIIIQDDNNryIHYYLQKyqrsnqntcinyrPIv 621
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  494 --------GTTRAM-EYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFrsymdqeKKYGMSITETF 564
Cdd:CHL00207  622 wvgekiniGQILADgSDIDNSELALGQNVLVAYMPWEGYNFEDAILINKRLVYEDLFTSIHI-------EKYEIELRQTK 694
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  565 EKPQRTNTLRMKHGTYD--KLDDDGLIAPGVRVSGEDVIIGKTTPIS----PDEEELGQRTAYHSKRDA-STPLRSTENG 637
Cdd:CHL00207  695 LGSEEITRNIPNVSEYSlkNLDENGIISIGSKVLAGDILVGKITPKGesdqLPEGKLLRAIFGEKAKDVkDTSLRMPNGG 774
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  638 ---IVDQVLVTTNQ-DGLKF---VKVRVRTTKIP--QIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIP 708
Cdd:CHL00207  775 ygrVIKVEIFSRSKgDELKFgyyLKIRVFIAQIRkiQVGDKLAGRHGNKGIISRILPRQDMPYLPDGTPPDIILNPLGVP 854
                         730
                  ....*....|...
gi 396941823  709 SRMTVAHLIECLL 721
Cdd:CHL00207  855 SRMNVGQLFECLL 867
RNA_pol_Rpb2_2 pfam04561
RNA polymerase Rpb2, domain 2; RNA polymerases catalyze the DNA dependent polymerization of ...
1-97 9.84e-29

RNA polymerase Rpb2, domain 2; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the lobe domain. DNA has been demonstrated to bind to the concave surface of the lobe domain, and plays a role in maintaining the transcription bubble. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 1 (DRI).


Pssm-ID: 398318 [Multi-domain]  Cd Length: 185  Bit Score: 113.60  E-value: 9.84e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823    1 LEMLKPCVEDGFVIQDRETALDFIGRrGTALGIKKEKRIQYAKDILQK-----EFLPHITQLEGFESR--KAFFLGYMIN 73
Cdd:pfam04561  83 LELLKPELEEAENIYTQEEALDYIGK-GFALRRGEEPRLQRAREILYSrdpkyNLNKHLGLNEPFENErlKAQDILYMID 161
                          90       100
                  ....*....|....*....|....
gi 396941823   74 RLLLCALDRKDQDDRDHFGKKRLD 97
Cdd:pfam04561 162 RLLNLKLGRRKPDDIDHLGNKRVR 185
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
506-770 2.02e-25

DNA-directed RNA polymerase subunit beta; Reviewed


Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 112.89  E-value: 2.02e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  506 ELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLffrsymdqekkygmSITEtFEKPQRtNTlrmKHG----TYD 581
Cdd:PRK00405  712 ELALGQNVLVAFMPWNGYNFEDAILISERLVKEDVFTSI--------------HIEE-YEIEAR-DT---KLGpeeiTRD 772
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  582 ----------KLDDDGLIAPGVRVSGEDVIIGKTTP-----ISPdEEEL-----GQRTAYHskRDAStpLR--STENGIV 639
Cdd:PRK00405  773 ipnvseealrNLDESGIVRIGAEVKPGDILVGKVTPkgeteLTP-EEKLlraifGEKARDV--KDTS--LRvpHGEEGTV 847
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  640 DQVLV-TTNQDG-------LKFVKVRV---RttKIpQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIP 708
Cdd:PRK00405  848 IDVKVfTRIEQGdelppgvNKLVKVYIaqkR--KI-QVGDKMAGRHGNKGVVSRILPVEDMPYLEDGTPVDIVLNPLGVP 924
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 396941823  709 SRMTVAHLIECLLSKVAALSGNEGdASP-FTDITVEGISKLLREHGYQS*GFEVMYNGHTGKK 770
Cdd:PRK00405  925 SRMNIGQILETHLGWAAKGLGIKF-ATPvFDGAKEEEIKELLEEAGLPEDGKTTLYDGRTGEP 986
RNA_pol_Rpb2_5 pfam04567
RNA polymerase Rpb2, domain 5; RNA polymerases catalyze the DNA dependent polymerization of ...
371-435 3.15e-22

RNA polymerase Rpb2, domain 5; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 5, is also known as the external 2 domain.


Pssm-ID: 428013 [Multi-domain]  Cd Length: 53  Bit Score: 90.29  E-value: 3.15e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 396941823  371 WSSLLNEGLVEYIDAEEEESILIAMQPEDLEPAEaneendldvdpaKRIRVSHHATTFTHCEIHP 435
Cdd:pfam04567   1 WSDLLREGVIEYLDAEEEETSMIAMTPEDLEESS------------REEREGPYAHTYTHCEIHP 53
rpoB CHL00001
RNA polymerase beta subunit
506-721 1.34e-20

RNA polymerase beta subunit


Pssm-ID: 214330 [Multi-domain]  Cd Length: 1070  Bit Score: 97.28  E-value: 1.34e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  506 ELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRsymdqekKYGMSITETFEKPQR-TN--------TLRmk 576
Cdd:CHL00001  648 ELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDIYTSFHIR-------KYEIQTHVTSQGPERiTKeiphleahLLR-- 718
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  577 HgtydkLDDDGLIAPGVRVSGEDVIIGKTTPISPDEEE-----------LGQRTAyhSKRDasTPLRSTENG---IVDQV 642
Cdd:CHL00001  719 N-----LDKNGIVMLGSWVETGDILVGKLTPQEAEESSyapegrllraiFGIQVS--TSKE--TCLKLPIGGrgrVIDVR 789
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  643 LVTTNQDGLKFVK-VRV---RTTKIpQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIE 718
Cdd:CHL00001  790 WIQKKGGSSYNPEtIHVyilQKREI-QVGDKVAGRHGNKGIISKILPRQDMPYLQDGTPVDMVLNPLGVPSRMNVGQIFE 868

                  ...
gi 396941823  719 CLL 721
Cdd:CHL00001  869 CLL 871
PRK09603 PRK09603
DNA-directed RNA polymerase subunit beta/beta';
86-731 3.97e-18

DNA-directed RNA polymerase subunit beta/beta';


Pssm-ID: 181983 [Multi-domain]  Cd Length: 2890  Bit Score: 89.98  E-value: 3.97e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823   86 DDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIfRYMQRTVEEAHDFNMKL-AINAKTITSGLKYALATGNwgeqkkams 164
Cdd:PRK09603  455 DDRDHLGNRRIRAVGELLANELHSGLVKMQKTI-KDKLTTMSGAFDSLMPHdLVNSKMITSTIMEFFMGGQ--------- 524
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  165 sragVSQVLNRYTYSSTLSHLRRTNTpIGrDGKLAK------PRQLHNTHWGLVCPAETPEGQACGLVKNLSlmscisvg 238
Cdd:PRK09603  525 ----LSQFMDQTNPLSEVTHKRRLSA-LG-EGGLVKdrvgfeARDVHPTHYGRICPIETPEGQNIGLINTLS-------- 590
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  239 tdpmpiiTFlsewgmepledyvphqspdaTRVfvngvwhgvhrnparlmetlrtlrrkgdinpevsmirdirekelkifT 318
Cdd:PRK09603  591 -------TF--------------------TRV-----------------------------------------------N 596
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  319 DAGRVYRPLfiveddeslghkeLKVRKGHIAklmateyqdieggfedveeytwssllneGLVEYIDAEEEESILIAMQPE 398
Cdd:PRK09603  597 DLGFIEAPY-------------KKVVDGKVV----------------------------GETIYLTAIQEDSHIIAPAST 635
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  399 DLEPAEANEENDLDVDPAKRIRVSHHaTTFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNV- 477
Cdd:PRK09603  636 PIDEEGNILGDLIETRVEGEIVLNEK-SKVTLMDLSSSMLVGVAASLIPFLEHDDANRALMGTNMQRQAVPLLRSDAPIv 714
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  478 -------------------------RMDTM-----------ANILYYP-QKPLGTTRAMEY------------------- 501
Cdd:PRK09603  715 gtgiekiiardswgaikanragvveKIDSKniyilgegkeeAYIDAYSlQKNLRTNQNTSFnqvpivkvgdkveagqiia 794
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  502 ----LKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRS--LFFRSYMDQEKKYGmsITETFEKPQRTNTLRM 575
Cdd:PRK09603  795 dgpsMDRGELALGKNVRVAFMPWNGYNFEDAIVVSERITKDDIFTSthIYEKEVDARELKHG--VEEFTADIPDVKEEAL 872
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  576 KHgtydkLDDDGLIAPGVRVSGEDVIIGKTTP---ISPDEEELGQRTAYHSK---------------------------- 624
Cdd:PRK09603  873 AH-----LDESGIVKVGTYVSAGMILVGKTSPkgeIKSTPEERLLRAIFGDKaghvvnkslycppslegtvidvkvftkk 947
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  625 ---RDAST-------------------------------------PLRS------------------------------- 633
Cdd:PRK09603  948 gyeKDARVlsayeeekakldmehfdrltmlnreellrvssllsqaILEEpfshngkdykegdqipkeeiasinrftlasl 1027
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  634 --------------TENGIVDQ--VLVTTNQDGL--------------KFVKVRVRTTKIPQIGDKFASRHGQKGTIGIT 683
Cdd:PRK09603 1028 vkkyskevqnhyeiTKNNFLEQkkVLGEEHEEKLsilekddilpngviKKVKLYIATKRKLKVGDKMAGRHGNKGIVSNI 1107
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....*...
gi 396941823  684 YRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNE 731
Cdd:PRK09603 1108 VPVADMPYTADGEPVDIVLNPLGVPSRMNIGQILEMHLGLVGKEFGKQ 1155
PRK14844 PRK14844
DNA-directed RNA polymerase subunit beta/beta';
71-718 1.16e-14

DNA-directed RNA polymerase subunit beta/beta';


Pssm-ID: 173305 [Multi-domain]  Cd Length: 2836  Bit Score: 78.51  E-value: 1.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823   71 MINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTVEE---AHDFnmklaINAKTITSGL 147
Cdd:PRK14844  449 IVRKIVLLRDGQGSVDDIDHLGNRRVRSVGEFIENQFRTGLLKLERAVVDSMSTSSLDkvsPSDF-----INPKVLTNVL 523
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  148 KyalatgnwgeqkkAMSSRAGVSQVLNRYTYSSTLSHLRRTNT--PIG--RDGKLAKPRQLHNTHWGLVCPAETPEGQAC 223
Cdd:PRK14844  524 R-------------DFFNSSQLSQFMDQTNPLSEITHKRRLSAlgPGGltRERAGFEVRDVHPTHYGRICPIETPEGQNI 590
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  224 GLVKNLSLMSCISvgtdpmpiitflsEWGM--EPLEDYVPHQSPDATRvFVNGVWHGVHR---------NPARLMETLRT 292
Cdd:PRK14844  591 GLINSLAIYARIN-------------KYGFieSPYRKVVNRVVTDQIE-YLSAIDEGLYYiadtsakldENNCFVDDMLY 656
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  293 LRRKGDI----NPEVSMIrDIREKELkIFTDAGRVyrPlFIVEDDESLGHKELKVRKGHIAKLMATEYQDIEGGFEDVEE 368
Cdd:PRK14844  657 CRYAGSFvmvsSDQVSYI-DVSPKQV-ISVAASLI--P-FLENDDANRALMGSNMQRQAVPLLKPTAPLVATGMESFVAS 731
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  369 YTWSSLL--NEGLVeyiDAEEEESILI-AMQPEDLepaeaneeNDLDVD--PAKRIRVSHHATTFthceihpsmilgvaa 443
Cdd:PRK14844  732 GSGAVVLakRDGIV---DSSDSNSIVIrAFDKERV--------NYLDVDiyHLRKFQRSNHNTCI--------------- 785
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  444 siipfpdhNQSPRntyqsamgkqamgVFLTNYNVRMDTMANilyYPQKPLGttrameylkfrELPAGQNAIVAIACYSGY 523
Cdd:PRK14844  786 --------NQKPL-------------VCVGDYVKEGDVIAD---GPAINSG-----------ELALGQNLLVAFMSWQGY 830
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  524 NQEDSMIMNQSSIDRGLFRSLFFRSY--------MDQEKkygmsITETFEKPQRTNtlrMKHgtydkLDDDGLIAPGVRV 595
Cdd:PRK14844  831 NFEDSIIISSEVVKKDLFTSIHIEEFecvvhdtpLGSEK-----ITRAIPGVNEEN---LYH-----LDDSGIVKIGTRV 897
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  596 SGEDVIIGKTTP------------------------------ISPDEE--------------ELGQRtAYHSKRDASTPL 631
Cdd:PRK14844  898 GPGYILVGKVTPkpslslppetkllmtifgeksfdcadsslyTSPDVEgtvidvqvftrrgvEENER-ALLIKQKEINDF 976
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396941823  632 RSTENGIVD-----------QVLVTT-NQDGLKF---------------------------------------------- 653
Cdd:PRK14844  977 EKERDYIINvtseyfydelkKLLINSgSQDREKFdsiereqwwgiglknqsiseqvkslkkdfdekvshaiaqfkrkvek 1056
                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 396941823  654 --------------VKVRVRTTKIPQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIE 718
Cdd:PRK14844 1057 lhegydlpqgvsmsVKVFIAVKHSLQPGDKMAGRHGNKGVISRVVPVEDMPYLEDGTPVDIILNPLGVPSRMNVGQILE 1135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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