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Conserved domains on  [gi|402479673|gb|AFQ56182|]
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Glucarate transporter [Bacillus subtilis QB928]

Protein Classification

MFS transporter( domain architecture ID 11489925)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
27-434 1.35e-163

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


:

Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 466.81  E-value: 1.35e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673   27 LVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQGAIg 106
Cdd:TIGR00893   1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFA- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  107 ffsagTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVM 186
Cdd:TIGR00893  80 -----GAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIE 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  187 GIAGILLAVIWLKTVYEPKKHPKVNEAELAYIEQGGGLISMDDsksKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLT 266
Cdd:TIGR00893 155 GVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQG---KGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGL 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  267 YFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLLSCSMIVCNYTDS 346
Cdd:TIGR00893 232 GFFLTWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLMFATNYVNI 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  347 AWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAIAA 426
Cdd:TIGR00893 312 PYAALALVALGFFGLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALIG 391

                  ....*...
gi 402479673  427 ILSYLLLV 434
Cdd:TIGR00893 392 ALSYLLLV 399
 
Name Accession Description Interval E-value
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
27-434 1.35e-163

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 466.81  E-value: 1.35e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673   27 LVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQGAIg 106
Cdd:TIGR00893   1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFA- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  107 ffsagTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVM 186
Cdd:TIGR00893  80 -----GAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIE 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  187 GIAGILLAVIWLKTVYEPKKHPKVNEAELAYIEQGGGLISMDDsksKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLT 266
Cdd:TIGR00893 155 GVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQG---KGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGL 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  267 YFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLLSCSMIVCNYTDS 346
Cdd:TIGR00893 232 GFFLTWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLMFATNYVNI 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  347 AWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAIAA 426
Cdd:TIGR00893 312 PYAALALVALGFFGLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALIG 391

                  ....*...
gi 402479673  427 ILSYLLLV 434
Cdd:TIGR00893 392 ALSYLLLV 399
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
18-433 4.16e-110

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 329.15  E-value: 4.16e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  18 RWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSF 97
Cdd:cd17319    1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  98 FTLLQGAIGFFsagtaiILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSF 177
Cdd:cd17319   81 FTALTGFATSL------TSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLF 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 178 GWHSVFVVMGIAGILLAVIWLKTVyepkkhpkvneaelayieqggglismddskskqeteskwpyikqlltnRMLIGVYI 257
Cdd:cd17319  155 GWRWAFIIEGLLGLLLAVLWWFYL------------------------------------------------RQVWGLAL 186
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 258 AQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILlkkgrsLTFARKVPIIAGMLLSCS 337
Cdd:cd17319  187 GYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRL------LRGARRLVIIIGLLLAAV 260
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 338 MIVCNY-TDSAWLVVVIMSLAFFGKGFGALG-WAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGA 415
Cdd:cd17319  261 GLLLAYlTTSPVVAVILLSLAGFGIGAASPVfWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAA 340
                        410
                 ....*....|....*...
gi 402479673 416 LVFVGANAIAAILSYLLL 433
Cdd:cd17319  341 FLFLAAVALLAALLVLLL 358
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
13-439 1.02e-73

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 235.92  E-value: 1.02e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  13 KKTSVRWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSI 92
Cdd:COG2271    3 APSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  93 FFWSFFTLLQGAIgffsagTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGW 172
Cdd:COG2271   83 LLWGLATLLFGFA------TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGW 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 173 LTHSFGWHSVFVVMGIAGILLAVIwlktvyepkkhpkvneaelayieqggglismddskskqeteskwpyikqlltnrML 252
Cdd:COG2271  157 LLAAFGWRAAFLILGLPGLLLALL------------------------------------------------------RF 182
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 253 IGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKgrsltfaRKVPIIAGM 332
Cdd:COG2271  183 WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR-------RKLVLAIGL 255
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 333 LLS-CSMIVCNYTDSAWLVVVIMSLA-FFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATG 410
Cdd:COG2271  256 LLAaLALLLLALLPSPALAIALLFLAgFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG 335
                        410       420
                 ....*....|....*....|....*....
gi 402479673 411 sFNGALVFVGANAIAAILSYLLLVGPIKR 439
Cdd:COG2271  336 -YQAAFLLLAALALLAALLALLLLRETRK 363
MFS_1 pfam07690
Major Facilitator Superfamily;
25-399 3.25e-33

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 128.30  E-value: 3.25e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673   25 LFLVTSINYADRATLSIT-GDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLqg 103
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL-- 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  104 aigfFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVF 183
Cdd:pfam07690  79 ----LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  184 VVMGIAGILLAVIWLKTVYEPKKHPKvneaelayieqggglismddSKSKQETESKWPYIKQLLTNRMLIGVYIAqYCIT 263
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKRP--------------------KPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFG 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  264 TLTYFFLTWFPVYlVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFarkvpIIAGMLLSCSMIVCNY 343
Cdd:pfam07690 214 FAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLA-----LLLLILAALGLLLLSL 287
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 402479673  344 TDSAWLVVVIMSLAFFGKGF-GALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTP 399
Cdd:pfam07690 288 TLSSLWLLLALLLLGFGFGLvFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
glpT PRK11273
glycerol-3-phosphate transporter;
57-447 2.44e-14

glycerol-3-phosphate transporter;


Pssm-ID: 236889 [Multi-domain]  Cd Length: 452  Bit Score: 74.75  E-value: 2.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  57 MGYVFSAFGWAYVIGQLPGGWLLDRFGSKtiialsiFFWSFFTLLQGAIGFFS-----AGTAIILLFALRFLVGLSEAPS 131
Cdd:PRK11273  65 LGFALSGISIAYGFSKFIMGSVSDRSNPR-------VFLPAGLILAAAVMLFMgfvpwATSSIAVMFVLLFLCGWFQGMG 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 132 FPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPL----MGWLTHsfgWHSVFVVMGIAGILLAVIWLKTVYEPKKH 207
Cdd:PRK11273 138 WPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLPPLLfllgMAWFND---WHAALYMPAFAAILVALFAFAMMRDTPQS 214
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 208 ---PKVNEAELAYIEQGgglismdDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMS 284
Cdd:PRK11273 215 cglPPIEEYKNDYPDDY-------NEKHEQELTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFA 287
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 285 ILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFarkvpiIAGMLLSCSMIVCNYTDSAWLVVVIMsLAFFGKGFG 364
Cdd:PRK11273 288 LDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGNRGATG------VFFMTLVTIATIVYWLNPAGNPTVDM-ACMIVIGFL 360
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 365 ALGWAVVS-----DTSPKECAGLSGGLFNTFGNI-ASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIK 438
Cdd:PRK11273 361 IYGPVMLIglhalELAPKKAAGTAAGFTGLFGYLgGSVAASAIVGYTVDFFGWDGGFMVMIGGSILAVILLIVVMIGEKR 440

                 ....*....
gi 402479673 439 RVVLKKQEQ 447
Cdd:PRK11273 441 HHEELLQKR 449
 
Name Accession Description Interval E-value
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
27-434 1.35e-163

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 466.81  E-value: 1.35e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673   27 LVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQGAIg 106
Cdd:TIGR00893   1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFA- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  107 ffsagTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVM 186
Cdd:TIGR00893  80 -----GAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIE 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  187 GIAGILLAVIWLKTVYEPKKHPKVNEAELAYIEQGGGLISMDDsksKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLT 266
Cdd:TIGR00893 155 GVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQG---KGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGL 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  267 YFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLLSCSMIVCNYTDS 346
Cdd:TIGR00893 232 GFFLTWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLMFATNYVNI 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  347 AWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAIAA 426
Cdd:TIGR00893 312 PYAALALVALGFFGLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALIG 391

                  ....*...
gi 402479673  427 ILSYLLLV 434
Cdd:TIGR00893 392 ALSYLLLV 399
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
18-433 4.16e-110

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 329.15  E-value: 4.16e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  18 RWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSF 97
Cdd:cd17319    1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  98 FTLLQGAIGFFsagtaiILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSF 177
Cdd:cd17319   81 FTALTGFATSL------TSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLF 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 178 GWHSVFVVMGIAGILLAVIWLKTVyepkkhpkvneaelayieqggglismddskskqeteskwpyikqlltnRMLIGVYI 257
Cdd:cd17319  155 GWRWAFIIEGLLGLLLAVLWWFYL------------------------------------------------RQVWGLAL 186
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 258 AQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILlkkgrsLTFARKVPIIAGMLLSCS 337
Cdd:cd17319  187 GYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRL------LRGARRLVIIIGLLLAAV 260
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 338 MIVCNY-TDSAWLVVVIMSLAFFGKGFGALG-WAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGA 415
Cdd:cd17319  261 GLLLAYlTTSPVVAVILLSLAGFGIGAASPVfWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAA 340
                        410
                 ....*....|....*...
gi 402479673 416 LVFVGANAIAAILSYLLL 433
Cdd:cd17319  341 FLFLAAVALLAALLVLLL 358
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
13-439 1.02e-73

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 235.92  E-value: 1.02e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  13 KKTSVRWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSI 92
Cdd:COG2271    3 APSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  93 FFWSFFTLLQGAIgffsagTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGW 172
Cdd:COG2271   83 LLWGLATLLFGFA------TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGW 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 173 LTHSFGWHSVFVVMGIAGILLAVIwlktvyepkkhpkvneaelayieqggglismddskskqeteskwpyikqlltnrML 252
Cdd:COG2271  157 LLAAFGWRAAFLILGLPGLLLALL------------------------------------------------------RF 182
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 253 IGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKgrsltfaRKVPIIAGM 332
Cdd:COG2271  183 WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR-------RKLVLAIGL 255
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 333 LLS-CSMIVCNYTDSAWLVVVIMSLA-FFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATG 410
Cdd:COG2271  256 LLAaLALLLLALLPSPALAIALLFLAgFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG 335
                        410       420
                 ....*....|....*....|....*....
gi 402479673 411 sFNGALVFVGANAIAAILSYLLLVGPIKR 439
Cdd:COG2271  336 -YQAAFLLLAALALLAALLALLLLRETRK 363
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
26-416 1.52e-63

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 209.92  E-value: 1.52e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673   26 FLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLlqgai 105
Cdd:TIGR00881   1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNL----- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  106 gFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMG-WLTHSFGWHSVFV 184
Cdd:TIGR00881  76 -FFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLfGIAELYSWHWVFI 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  185 VMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYIEQgggliSMDDSKSKQETESKWP-YIKQLLTNRMLIGVYIAQYCIT 263
Cdd:TIGR00881 155 VPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNEE-----PDGDAEKKEEELTKKQiFLQYVLLNKVLWYISLGYVFVY 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  264 TLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLK-KGRSLTFARKVPIIAGMLLSCSMIVCN 342
Cdd:TIGR00881 230 VVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNgRRGPLAVFFMALIIVSLLVYWLNPAAN 309
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 402479673  343 YTdsaWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGsFNGAL 416
Cdd:TIGR00881 310 PL---MDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG-WAGAF 379
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
22-424 1.87e-53

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 182.75  E-value: 1.87e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  22 VFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLL 101
Cdd:cd17380    1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 102 QGAIgffsAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHS 181
Cdd:cd17380   81 TPLL----AYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 182 VFVVMGIAGILLAVIWlktvyepkkhpkvneaelayieqggglismddskskqeteskWPYIKQLLTnrmligVYIAQYC 261
Cdd:cd17380  157 VFYFFGLLGLLWALVW------------------------------------------LIYLPPVWA------IIVAHFC 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 262 ITTLTYFFLTWFPVYLVQARGmSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLLSC-SMIV 340
Cdd:cd17380  189 MNWGFYILLSWLPTYFHEVLV-PLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPAlFLLL 267
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 341 CNYTDSAWLVVVIMSLAFFGKGFGALGWAV-VSDTSPKeCAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFngALVFV 419
Cdd:cd17380  268 LSHTDSFSLALLCMSVALGLSAFSSSGVLVnHQDIAPN-YAGIVFGISNTAGTIPGIVGVYLTGYILEATGSW--SLVFV 344

                 ....*
gi 402479673 420 GANAI 424
Cdd:cd17380  345 LAAVV 349
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
23-406 2.50e-47

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 167.41  E-value: 2.50e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  23 FMLFLVTSINYADRATLSI-----TGDSVQHDLGLDSVAM-----------------GYVFSAFGWAYVIGQLPGGWLLD 80
Cdd:cd17318    2 ILLFLGFAVVYAMRVNLSVaivamVNSTATHDNNNTSTDKdtlpveapefdwsektqGIILSSFFYGYILTQIPGGYLAE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  81 RFGSKTIIALSIFFWSFFTLLQGAigffSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY 160
Cdd:cd17318   82 KYGAKRVLGYSILITALLTLLTPL----AARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQ 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 161 FAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVyepkkhpkvneaelayieqggglismddskskqeteskw 240
Cdd:cd17318  158 FGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV--------------------------------------- 198
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 241 pyikqlltnRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGR-S 319
Cdd:cd17318  199 ---------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGIlS 269
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 320 LTFARKVPIIAGMLL-SCSMIVCNY-TDSAWLVVVIMSLAFFGKGFGALGWAV-VSDTSPKeCAGLSGGLFNTFGNIASI 396
Cdd:cd17318  270 TTTVRKLFTSIGFLGpGVFLIALGYlGSNATLAVVFLTLSVGLSGACYSGFLVnHLDLAPN-YAGTLMGITNTAATIAGI 348
                        410
                 ....*....|
gi 402479673 397 TTPIIIGYIV 406
Cdd:cd17318  349 ISPLIVGAIV 358
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
16-432 6.73e-47

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 166.21  E-value: 6.73e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  16 SVRWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFW 95
Cdd:COG2223    1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  96 SFFTLLqgaigfFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTH 175
Cdd:COG2223   81 GIGLLL------LALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIA 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 176 SFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAelayieqggglismddskskqeteSKWPYIKQLLTNRMLIGV 255
Cdd:COG2223  155 AFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAK------------------------ASLRDQLEALRDPRFWLL 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 256 YIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDillKKGRsltfaRKVPIIAGMLLS 335
Cdd:COG2223  211 SLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSD---RIGG-----RRVLLIVFALMA 282
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 336 CSMIVCNY-TDSAWLVVVIMSLAFFGKGFG-ALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFN 413
Cdd:COG2223  283 LGLLLLALaLGSLWLFLVLFLLLGLALGGGnGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYT 362
                        410       420
                 ....*....|....*....|
gi 402479673 414 GA-LVFVGANAIAAILSYLL 432
Cdd:COG2223  363 AAfLVFAVLALVALVLTLLL 382
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
47-428 1.68e-37

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 140.84  E-value: 1.68e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  47 QHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALsiffwsfFTLLQGAIGFF-SAGTAIILLFALRFLVG 125
Cdd:cd17475   23 QEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAV-------GLLLMGAAALLmALVGSYPVLLVLLFLVG 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 126 LSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPK 205
Cdd:cd17475   96 AGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPP 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 206 khpkvneaelayieqggglismDDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSI 285
Cdd:cd17475  176 ----------------------AASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSV 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 286 LEAGFVASLPALCGFAGGVLGGIVSDILLKKGRsltfaRKVPIIAGMLLSCSMIVCNYTDSAWLVVVIMSLAFFgKGFGA 365
Cdd:cd17475  234 VAAGALLAVAQLGGALGRIGLGRVSDRVFGGRR-----RPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLIL-LGLFA 307
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 402479673 366 LGW-----AVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAIAAIL 428
Cdd:cd17475  308 IGWnglylTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAAL 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
18-395 4.25e-37

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 138.95  E-value: 4.25e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  18 RWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSF 97
Cdd:COG2814    8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  98 FTLLqgaigfFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSF 177
Cdd:COG2814   88 GSLL------CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 178 GWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKvneaelayieqggglismddskskqetESKWPYIKQLLTNRMLIGVYI 257
Cdd:COG2814  162 GWRWVFLVNAVLALLALLLLLRLLPESRPAAR---------------------------ARLRGSLRELLRRPRLLLLLL 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 258 AQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDillKKGRsltfaRKVPIIAGMLLSCS 337
Cdd:COG2814  215 LAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD---RFGR-----RRLLLIGLLLLALG 286
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 402479673 338 MIVCNYTDSAWLVVVIMSLAFFGKGF-GALGWAVVSDTSPKECAGLSGGLFNTFGNIAS 395
Cdd:COG2814  287 LLLLALAGSLWLLLLALFLLGFGFGLlFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
15-449 4.91e-35

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 135.64  E-value: 4.91e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673   15 TSVRWFIVFMLFLVTSINYADRATLSITG---------------------DSVQHDLGLDSVAM-GYVFSAFGWAYVIGQ 72
Cdd:TIGR00894  14 CSFRLFLSFLLHICNVIIIAQRICLSLTMvamvnkenstdlaclsaenelDNIKNPNFKWSGALqGLILSSHFYGQIIIQ 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673   73 LPGGWLLDRFGSKTIIALSIFFWSFFTLLQgaigFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTAS 152
Cdd:TIGR00894  94 IPVGYLAGKYVFKWSIGIGMFLSSVISIVI----PWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLL 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  153 AFFNSAQYFAIVIFSPLMGWLTHSF-GWHSVFVVMGIAGILLAVIWLKTVYE-PKKHPKVNEAELAYIeqGGGLISMDDS 230
Cdd:TIGR00894 170 GMSTSGFQLGTFIFLPISGWLCESWgGWPMIFYVFGIVGCAWSLLWFVFPADdPSIHPCISKFEKKYI--NSSLQGQKGS 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  231 KSKqetesKWPyIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVS 310
Cdd:TIGR00894 248 TRQ-----SLP-IKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLA 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  311 DILLKKGR-SLTFARKVPIIAGMLLSCSMIVCNY--TDSAWLVVVIMSLAffgKGFGALGWAVVSDTSPK---ECAGLSG 384
Cdd:TIGR00894 322 DFLKSSKTlSLTAARKIFNGIGGLGPGIFAYALPylSAAFYLTIIILTLA---NAVSSGPLAGVLINSLDlapRFLGFIK 398
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 402479673  385 GLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAIAAI-LSYLLLVGPIKRVVLKKQEQDP 449
Cdd:TIGR00894 399 GITGLPGFIGGLIASTLAGNILSQDSKNVWLIVFLIMAFVNILcVIFYLIFGSAERQDWAKEEKDT 464
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
48-433 9.49e-34

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 130.39  E-value: 9.49e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  48 HDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLqgaigfFSAGTAIILLFALRFLVGLS 127
Cdd:cd17325   24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL------FAFATSYWQLLLARFLQGLA 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 128 EAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKH 207
Cdd:cd17325   98 SAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPP 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 208 PKvneaelayieqggglismddsKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILE 287
Cdd:cd17325  178 PN---------------------KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQ 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 288 AGFVASLPALCGFAGGVLGGIVSDillkkgrslTFARKVPIIAGMLLSC-SMIVCNYTDSAWLVVVIMSLAFFGKGFGAL 366
Cdd:cd17325  237 IGLLFGAQGLASALSQPPAGKLSD---------RIGRKPLILIGLLLSAvALLLLPLATSFWLLLLLLALLGLGLGLVFP 307
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 402479673 367 GW-AVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLL 433
Cdd:cd17325  308 ATlALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_1 pfam07690
Major Facilitator Superfamily;
25-399 3.25e-33

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 128.30  E-value: 3.25e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673   25 LFLVTSINYADRATLSIT-GDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLqg 103
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL-- 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  104 aigfFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVF 183
Cdd:pfam07690  79 ----LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  184 VVMGIAGILLAVIWLKTVYEPKKHPKvneaelayieqggglismddSKSKQETESKWPYIKQLLTNRMLIGVYIAqYCIT 263
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKRP--------------------KPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFG 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  264 TLTYFFLTWFPVYlVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFarkvpIIAGMLLSCSMIVCNY 343
Cdd:pfam07690 214 FAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLA-----LLLLILAALGLLLLSL 287
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 402479673  344 TDSAWLVVVIMSLAFFGKGF-GALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTP 399
Cdd:pfam07690 288 TLSSLWLLLALLLLGFGFGLvFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
22-415 1.10e-32

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 128.12  E-value: 1.10e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  22 VFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLL 101
Cdd:cd17328    1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 102 QGAIGFFsagtaiILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFnsaqYFAIVIFS----PLMGWLTHSF 177
Cdd:cd17328   81 SSFAPNF------WQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVF----YFAIPLGSglgyVVGGLVAQAT 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 178 -GWHSVFVVMGIAGILLAVIWLKTVYEPKKHPkvneaelayIEQGGGLISmddskskqETESKWPYIKQLLTNRMLIGVY 256
Cdd:cd17328  151 gGWRWAFRVTGVLGVLLAILLLLFVREPPRGA---------AEGGVMAKS--------TATSFLADLKALAKNPSFILST 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 257 IAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVA----SLPALCGFAGGVLGGIVSDILLKKGRSlTFARKVPIIAGM 332
Cdd:cd17328  214 LGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGlifgAITCIAGVLGVLLGGILADRLRRKTPR-ADPLVCAVGLLA 292
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 333 LLSCSMIVCNYTDSAWLVVVIMslAFFGKGFGALGWAVVSD----TSPKECAGLSGGLFNTFGN-IASITTPIIIGYIVN 407
Cdd:cd17328  293 AAPFLFLALVLALSNLLLAWVL--LFLGEFLLSLNWAPVFAillyVVIPTRRSTASAIQILLSHlLGDAGSPYLIGLISD 370

                 ....*...
gi 402479673 408 ATGSFNGA 415
Cdd:cd17328  371 LLRQNKDS 378
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
25-431 1.24e-32

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 127.16  E-value: 1.24e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  25 LFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLqga 104
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALL--- 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 105 igfFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLT--HSFGWHSV 182
Cdd:cd06174   78 ---FAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAV 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 183 FVVMGIAGILLAVIWLKTVYEPKKHPKVNEAElayieqggglismddskskQETESKWPYIKQLLTNRMLIGVYIAQYCI 262
Cdd:cd06174  155 FLIAAALALLAAILLLLVVPDPPESARAKNEE-------------------ASSKSVLKLLKRVLKNPGLWLLLLAIFLV 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 263 TTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDillkkgrsLTFARKVPIIAGMLLS--CSMIV 340
Cdd:cd06174  216 NLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSD--------RLIGRKPLLLIGLLLMalGLALL 287
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 341 CNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVG 420
Cdd:cd06174  288 LLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLA 367
                        410
                 ....*....|.
gi 402479673 421 ANAIAAILSYL 431
Cdd:cd06174  368 VLLLLAAILLL 378
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
18-428 2.28e-30

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 120.84  E-value: 2.28e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  18 RWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSF 97
Cdd:cd17312    1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  98 FTLlqgaigFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSF 177
Cdd:cd17312   81 ANI------FMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYY 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 178 GWHSVFVVMGIAGILLAVIWLKTVYEpkkHPkvneaelayieqggglismddskskqeteskwPYIKQLLTNRMLigVYI 257
Cdd:cd17312  155 GWRAAFLVPGIVGLVVAIILFFFLRD---SP--------------------------------PYVWVLSLAYAF--VYI 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 258 AQYCittltyfFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFarkVPIIAGMLLSCS 337
Cdd:cd17312  198 VRYA-------CLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIA---VIYMLLMTLSLA 267
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 338 MIVcNYTDSAWLVVVIMSLA-FFGKGFGALGWAVVS-DTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGA 415
Cdd:cd17312  268 LFW-FFPHNKLLSIVLLFLIgFFVGGPINLIGGAAAqDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVF 346
                        410
                 ....*....|...
gi 402479673 416 LVFVGANAIAAIL 428
Cdd:cd17312  347 YFLISAALLSVLL 359
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
23-433 3.53e-28

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 115.42  E-value: 3.53e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  23 FMLFLVTSINYAD----RATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFF 98
Cdd:cd17345    2 WQVFLGIFIGYAGyylvRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAII 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  99 TLLQGAIGffSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFG 178
Cdd:cd17345   82 NILIGFVP--SATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 179 ---WHSVFVVMGIAGILLAVIWLKTVY---EPKKHPKVNEAELAYIEQggglisMDDSKSKQETESKWPYIKQLLTNRML 252
Cdd:cd17345  160 dgwWRGAFIFPAIIAIIVAVIVLFLGKdtpESEGLPPIEEYKGDYPEE------ADGEEEEQELSAWEIFVKYVLKNKLL 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 253 IGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTfarkvPIIAGM 332
Cdd:cd17345  234 WYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPT-----GIIFMI 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 333 LLSCSMIVCNYTDSAWLVVVIMSLA-FFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNI-ASITTPIIIGYIVNATG 410
Cdd:cd17345  309 LVIVALIVYWLAPNVLVDLIALIALgFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLgGSVLATALIGIIVDHFG 388
                        410       420
                 ....*....|....*....|...
gi 402479673 411 SFNGALVFVGANAIAAILSYLLL 433
Cdd:cd17345  389 WNGGFIVLLASCILAIIFLALVA 411
MFS_SLC17A5 cd17381
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ...
53-405 7.46e-26

Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340939 [Multi-domain]  Cd Length: 397  Bit Score: 108.71  E-value: 7.46e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  53 DSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQGAIGFFSAGtaiiLLFALRFLVGLSEAPSF 132
Cdd:cd17381   63 DAETQGWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAG----YLIAVRALEGLGEGVTF 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 133 PGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEpkkhpkvne 212
Cdd:cd17381  139 PAMHAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLVMP--------- 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 213 aelayieqggglismddskskqeteskwpyikqlltnrmLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVA 292
Cdd:cd17381  210 ---------------------------------------LWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLS 250
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 293 SLPALCGFAGGVLGGIVSDILLKKGR-SLTFARKVPIIAGM------LLSCSMIVCNYTdsawLVVVIMSLAFFGKGFGA 365
Cdd:cd17381  251 ALPYLGCWLFMILSGQIADNLREKQNfSTVCVRKIFTLIGMigpavfLLAAGFTGCNYS----LAVAFLTISSTLGGFSA 326
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 402479673 366 LGWAVVS-DTSPKEcAGLSGGLFNTFGNIASITTPIIIGYI 405
Cdd:cd17381  327 SGFNINHlDIAPSY-AGILLGITNTFATIPGMVGPVIAKSL 366
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
6-433 3.74e-24

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 103.80  E-value: 3.74e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673   6 ASVTPAGKKTSVRWFIVFMLFLVtSINYadRATLSITG---DSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRF 82
Cdd:COG2807    4 TSSSARRSRRAGRWLLLLAIVLV-ALNL--RPAITSVGpllPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  83 GSKTIIALSIFfwsfftLLQGAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSeRGTASAFFNSAQYFA 162
Cdd:COG2807   81 GLERTLLLALL------LLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLG 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 163 IVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAyieqggglismddskskqeteskwpy 242
Cdd:COG2807  154 AALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAAS-------------------------- 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 243 IKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLvQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTF 322
Cdd:COG2807  208 LRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLL 286
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 323 ArkvpiIAGMLLSCSMIVCNYTDSAWLVVVIMSLAFFGkGFgALGWAVVSD--TSPKECAGLSgGLFNTFGNIASITTPI 400
Cdd:COG2807  287 L-----GLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGG-LF-PLALTLIGLraRTPAEAAALS-GMAQSVGYLLAALGPL 358
                        410       420       430
                 ....*....|....*....|....*....|...
gi 402479673 401 IIGYIVNATGSFNGALVFVGANAIAAILSYLLL 433
Cdd:COG2807  359 LVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
47-433 6.77e-22

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 96.87  E-value: 6.77e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  47 QHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFtllqGAIGFFSagTAIILLFALRFLVGL 126
Cdd:cd17473   27 QHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIG----GVAGLFL--DSLYALLASRALLGI 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 127 SEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLThSFGWHSVFVVMGIAGILLAVIWLKtVYEPKK 206
Cdd:cd17473  101 GVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVYLLALPVLILVLLF-LPEPAR 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 207 HpkvneaelayieqggglismddsksKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSIL 286
Cdd:cd17473  179 K-------------------------SKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAA 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 287 EAGFVASLPALCGFAGGVLGGIVSDILLKkgrsltfaRKVPIIAGMLLSCSMIVCNYTDSAWlvVVIMSLAFFGKGFGAL 366
Cdd:cd17473  234 LIGLALAIASLAGAIGALLFGRLKRRLGK--------RRLLAIGFALMALGFLLLALASGLW--VVLLGAILAGLGFGLL 303
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 367 GWAV---VSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLL 433
Cdd:cd17473  304 LPTLnswAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
22-431 7.70e-22

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 96.13  E-value: 7.70e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  22 VFMLFLVTSINYADRATLSITGDSVQH--DLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFT 99
Cdd:cd17316    1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 100 LLQGAIgffsagTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSF-- 177
Cdd:cd17316   81 LLIGLL------PTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsg 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 178 --GWHSVFVVMGIAGILLAVIWLKTVyepkkhpkvneaelayieqggglismddskskqeteskwpyikqlltnrMLIGV 255
Cdd:cd17316  155 dwGWRILFLIGALPALLALLLRRRTL-------------------------------------------------LLILL 185
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 256 YIaqyCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILlkkGRSLTFArkVPIIAGMLLS 335
Cdd:cd17316  186 WF---FISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI---GRKKTLV--IGLILSGILA 257
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 336 CSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGA 415
Cdd:cd17316  258 LPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVP 337
                        410
                 ....*....|....*.
gi 402479673 416 LVFVGANAIAAILSYL 431
Cdd:cd17316  338 ALILALLAIVALIVAL 353
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
13-406 1.69e-20

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 92.80  E-value: 1.69e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673   13 KKTSVRWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSI 92
Cdd:TIGR00895  10 PLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSI 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673   93 FFWSFFTLLQGAigffsaGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGW 172
Cdd:TIGR00895  90 LLFSVFTLLCAL------ATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGW 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  173 LTHSFGWHSVFVVMGIAGILLAVIWLKTVYEP------KKHPKVNEAELAYIEQGGGLISMDDSKSKQETESKWPYIKQL 246
Cdd:TIGR00895 164 LIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESidflvsKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKAL 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  247 LTNRMLIGVYI--AQYCITTLTYFFLT-WFPVYLVQArGMSILEAGFVASLPALCGFAGGVLGGIVSDILlkkGRSLTFA 323
Cdd:TIGR00895 244 FQGKTARITVLlwLLYFMLLVGVYFLTnWLPKLMVEL-GFSLSLAATGGALFNFGGVIGSIIFGWLADRL---GPRVTAL 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  324 rkVPIIAGMLLscSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIG 403
Cdd:TIGR00895 320 --LLLLGAVFA--VLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAG 395

                  ...
gi 402479673  404 YIV 406
Cdd:TIGR00895 396 YLL 398
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
19-401 1.59e-19

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 90.00  E-value: 1.59e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  19 WFIVFMLFLVTSINYADRATLS---ITGdsVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFW 95
Cdd:cd17327    4 LFILPLLCILYFLQYLDKSNISnaaVMG--MKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLW 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  96 SFFTLLQGAIGFFSAgtaiilLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIvIFSPLMGW--- 172
Cdd:cd17327   82 GLLTLLTAAVKNFGG------LIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGS-IFGGLLAYgvf 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 173 ---LTHSF-GWHSVFVVMGIAGILLAVI---WLKTVyePKKHPKVNEAELAYIeqgggLISMD-DSKSKQETESKWPYIK 244
Cdd:cd17327  155 kilGVGGLaGWRWLFIIEGLITIIIGLViffWLPDN--PSKAWFLTEEEKELA-----VERLRaNQTGKGDQKFKWKQIK 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 245 QLLTNRMLIGVYIAQYCITTLTYFFLTWFPVyLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFAr 324
Cdd:cd17327  228 EAFKDPRTWLLFLFFFCSQITNNGISNFLPL-ILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFA- 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 325 KVPIIAGmllSCSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAvvSDTspkeCAGLSG-----GLFNTFGNIASITTP 399
Cdd:cd17327  306 CVLALVG---SIILLAAPNPPGAYFAAYILGGGSYAGFPILLSWI--SSN----CAGYTKratvlAIMLIFYNVGNIVAP 376

                 ..
gi 402479673 400 II 401
Cdd:cd17327  377 QI 378
MFS_SLC37A4 cd17343
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ...
18-433 4.44e-19

Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340901 [Multi-domain]  Cd Length: 409  Bit Score: 88.93  E-value: 4.44e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  18 RWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSF 97
Cdd:cd17343    1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  98 FTLLqgaigfFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSF 177
Cdd:cd17343   81 TTVA------FSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSY 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 178 GWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYieqgggliSMDDSKSKQETESKWpyiKQLLTNRMLIGV-- 255
Cdd:cd17343  155 GWRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEE--------SKGKKKKSPRGESTL---KELLLSPFLWLLsl 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 256 -YIAQYCITTLTyffLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKK--GRSLTFARKVPIIAGM 332
Cdd:cd17343  224 gYLVVFGVKTAV---TDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKhgSSSRGNPRMPLALVFM 300
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 333 L-LSCSM-----IVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIV 406
Cdd:cd17343  301 AgLTVSLhlfrvHITSDSSELFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIA 380
                        410       420
                 ....*....|....*....|....*..
gi 402479673 407 NATGsFNGALVFVGANAIAAILSYLLL 433
Cdd:cd17343  381 KHYD-WRTAFLLLEILCAITVVILFLL 406
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
44-429 2.78e-18

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 86.06  E-value: 2.78e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  44 DSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQGAigffsaGTAIILLFALRFL 123
Cdd:cd17324   23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL------APSFALLLLARAL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 124 VGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYE 203
Cdd:cd17324   97 AGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPS 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 204 PKKHPKVNeaelayieqgGGLISMddskskqeteskwpyIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGM 283
Cdd:cd17324  177 LPPKKPGS----------LGLLSS---------------LLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGF 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 284 SILEAGFVASLPALCGFAGGVLGGIVSDILLKKgrsltfarkvPIIAGMLLSCSMIVCNYTDSAWLVVVIMSLAFFGKGF 363
Cdd:cd17324  232 SSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRR----------ALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGF 301
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 402479673 364 GALG---WAVVSDTSPkECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAIAAILS 429
Cdd:cd17324  302 FAAHsalQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
13-432 3.97e-18

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 85.68  E-value: 3.97e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  13 KKTSVRWFIVFMLFLVTSINYAdraTLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSI 92
Cdd:COG0738    4 KNYRRALIAIYLLFFLWGFATA---LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  93 FFWSFftllqGAIGFFSAGTAIILLFALrFLVGLseapsfpGNGRVVASWFPSS---ERGTASAFFNSAQYF---AIVIF 166
Cdd:COG0738   81 LLMAL-----GLLLFALAPSYPLLLLAL-FLLGL-------GLGLLDVAANPYVaalGPETAASRLNLLHAFfslGALLG 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 167 SPLMGWLTH---SFGWHSVFVVMGIAGILLAVIWLKTVYEpkkhpkvneaelayieqggglismDDSKSKQETESKWPYI 243
Cdd:COG0738  148 PLLGGLLILlglSLSWHLPYLILAVLLLLLALLFLRSKLP------------------------EIEEEEEEAAGSAASL 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 244 KQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLpalcGFAGGVLGGIVSDILLKKGRSLTFA 323
Cdd:COG0738  204 KSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSL----FWGGMTIGRFLGGFLLKRFGPVRLL 279
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 324 RKVPIIAGMLLSCSMIvcnyTDSAWLVVVIMSLAFFGKGFG-ALGWAVVSDTSPKEcAGLSGGLFNTFGNIASITTPIII 402
Cdd:COG0738  280 RLSALLAAVGLLLALL----APGPWLALIGLALVGLGLSLMfPTIFSLALDGLGKR-TAAAVSAVLIMGIVGGAIGPPLI 354
                        410       420       430
                 ....*....|....*....|....*....|
gi 402479673 403 GYIVNATGSFNGALVFVGANAIAAILSYLL 432
Cdd:COG0738  355 GFLADAFGLRAAFLVPLVCYLLILLLALAL 384
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
9-199 1.82e-17

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 82.55  E-value: 1.82e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673   9 TPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTII 88
Cdd:COG0477    3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  89 ALSIFFWSFFTLLQGAIgffsagTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSP 168
Cdd:COG0477   83 LIGLLLFGLASLLCGLA------PSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPL 156
                        170       180       190
                 ....*....|....*....|....*....|.
gi 402479673 169 LMGWLTHSFGWHSVFVVMGIAGILLAVIWLK 199
Cdd:COG0477  157 LGGLLVAALGWRWIFLINAPLGLLALVLRLR 187
MFS_SLC17A6_7_8_VGluT cd17382
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ...
58-424 3.45e-17

Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340940 [Multi-domain]  Cd Length: 380  Bit Score: 82.77  E-value: 3.45e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  58 GYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQGaigfFSAGTAIILLFALRFLVGLSEAPSFPGNGR 137
Cdd:cd17382   52 GLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLIP----IAARVHYGCVIFVRILQGLVEGVTYPACHG 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 138 VVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLktvyepkkhpkvneaelay 217
Cdd:cd17382  128 IWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWM------------------- 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 218 ieqgggLISMddskskqeteSKWPYIkqlltnrmligvyIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPAL 297
Cdd:cd17382  189 ------LVSM----------PVYAII-------------VANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHL 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 298 CGFAGGVLGGIVSDILLKKGR-SLTFARKVPIIAGMLLSCSMIVC-NYTDSAWLVVVIMSLAFFGKGFGALGWAVVS-DT 374
Cdd:cd17382  240 VMTIIVPIGGQLADYLRSRGIlSTTAVRKIFNCGGFGMEATFLLVvAFSHSPTVAISFLVLAVGFSGFAISGFNVNHlDI 319
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 402479673 375 SPKEcAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAI 424
Cdd:cd17382  320 APRY-ASILMGISNGIGTLSGMVCPVIVGALTKHKTREEWQYVFLIASLV 368
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
49-433 6.63e-17

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 81.96  E-value: 6.63e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  49 DLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQGAigffsaGTAIILLFALRFLVGLSE 128
Cdd:cd17371   28 EFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGF------AQNYWQLLILRALAGLGF 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 129 APSFPGNGRVVASWFPSSERGTASAFFNSAQY----FAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIwlktvyep 204
Cdd:cd17371  102 GGEWAAGAALMAEYVPARHRGKALGYVQSGWAvgwlLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFI-------- 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 205 kkHPKVNEAELAYIEQGGGliSMDDSKSKQETESKWPYIK-QLLTNRMLIGVYIAQYCITTltyffltWFPVYLVQARGM 283
Cdd:cd17371  174 --RRFVKEPPQWQAARAAR--RHFADRPSLRELFSPPLLRtTLLASLLATGALGGYYGITT-------WLPSYLTGERGL 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 284 SILEAGFVASLPALCGFAGGVLGGIVSDILlkkGRSLTFArkvpiiAGMLLSCSMIVC--NYTDSAWLVVVIMS-LAFFG 360
Cdd:cd17371  243 SFEGSAGYLVVTILGGFLGYLAGGFLADRI---GRRNNFA------LFALGSAISILLyfFLPLSPTLILILGFpLGFFA 313
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 402479673 361 KG-FGALGwAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLL 433
Cdd:cd17371  314 SGpFSGMG-AYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLL 386
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
22-431 1.31e-16

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 81.07  E-value: 1.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  22 VFMLFLVTSInyadratLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFwsfFTLL 101
Cdd:cd17321    5 VFLAALDVTI-------VNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLAL---FGLA 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 102 QGAIGFfsAGTAIILLFAlRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHS 181
Cdd:cd17321   75 SLLCAL--APSLAFLIAA-RALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRW 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 182 VFVVMGIAGILLaviwlktvyepkkhpkvneaelayieqggglismddskskqeteskwpyikqLLTNRMLIGVYIAQYC 261
Cdd:cd17321  152 IFLINVPIGLVA----------------------------------------------------LLLARTFSGAVLAAFL 179
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 262 ITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDillkkgrslTFARKVPIIAGMLLSC----S 337
Cdd:cd17321  180 LGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLAD---------RFGPRLVLVAGLLLTAvgllL 250
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 338 MIVCNYTDSAWLVVVIMSLAFFGKGF-GALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGAL 416
Cdd:cd17321  251 LALLGADSSVWLLLPGLVLLGLGLGLfATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLGD 330
                        410
                 ....*....|....*
gi 402479673 417 VFVGANAIAAILSYL 431
Cdd:cd17321  331 SGVAALLSAAAAAFA 345
MFS_FLVCR_like cd17398
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ...
18-431 3.94e-16

Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340956 [Multi-domain]  Cd Length: 406  Bit Score: 79.98  E-value: 3.94e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  18 RWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSiffwSF 97
Cdd:cd17398    2 RWIMLFLFCLYSMSNAFQWIQYAIISNIIVDYYGVSDTAVDWTSMIYMLTYIPLIFPATWLLEKYGLRVTVLLG----SF 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  98 FTLLQGAIGFFSAGTAII-LLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASA---FFN---SAQYFAIVIFSPLM 170
Cdd:cd17398   78 LNCLGAWLKLFSSSPDLFwVAMAGQTICALAQVFILGIPPRLAAVWFGPDEVSTATAigvFGNqlgVALGFVLPPLLVPN 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 171 GWLTHSFGWHSVFVVMGIAGI-----LLAVIWLKTvyEPKKHPKVNEAELAyieqggglismddsKSKQETESKWPYIKQ 245
Cdd:cd17398  158 SENKDEIGKGLSILFYGVAGIctalfILVIIFFKE--KPPIPPSRAQAAAQ--------------ELRSEDQSYLGSLKR 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 246 LLTNRMLI------GVYIAQYCI--TTLTYFFLTWFPVYLVQArgmsileaGFVASLPALCGFAGGVLGGIVSDillkkg 317
Cdd:cd17398  222 LFKNKGFLlllityGINTGVYYAisTLLNQMVLEYFPNEEVNA--------GWIGLTLVIAGLVGSVVAGIWLD------ 287
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 318 RSLTFaRKVPIIAGMLLSCSMIVCNYT---DSAWLVVVIMS-LAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNI 393
Cdd:cd17398  288 KTKKY-KETTIIVYILSFIGMVAFTFTldlGSIWVVFLTAGaLGFFMTGYLPVGFEFAAELTYPEPEGTSSGLLNASAQI 366
                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 402479673 394 ASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYL 431
Cdd:cd17398  367 FGIIFTLVMGALLDKVGALASNIVLSVALLLGTILTAF 404
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
50-430 2.62e-15

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 77.21  E-value: 2.62e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  50 LGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQGAIGFFSagtaiiLLFALRFLVGLSEA 129
Cdd:cd17478   26 LGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYW------LLLLLVALAGIGSA 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 130 pSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKtVYEPKKHPK 209
Cdd:cd17478  100 -AFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLR-LRPLKKPEA 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 210 VNEAelayieqggglismddsKSKQETESKWPYIKQLLtnrMLIGVYIAQYCIttlTYFFLTWFPVYLVQaRGMSILEAG 289
Cdd:cd17478  178 KKAA-----------------AKSSARSTLKGVWRALL---LLLIIVFLRSWV---LSSLTTFLPFYLVQ-RGYSLVFAG 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 290 FVASLPALCGFAGGVLGGIVSDillkkgrslTFARKVPIIAGMLLSC-SMIVCNYTDSAWLVVVIMSLAFFGKGFGALGW 368
Cdd:cd17478  234 LLLSLFLFAGAIGTLIGGPLSD---------RFGRRRVIIASLLLAApFLLLFLLTPGIWSYILLVLAGFLLFASFPVTV 304
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 402479673 369 AVVSDTSPkECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSY 430
Cdd:cd17478  305 VLAQELLP-GNVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
20-434 3.28e-15

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 76.86  E-value: 3.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  20 FIVFMLFLVTSINYAdratlsitgdsvqHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFwsfFT 99
Cdd:cd17489    9 FLSFYLLLPVLPLYA-------------HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLI---FA 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 100 LLQGAIGFfsaGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGW 179
Cdd:cd17489   73 LATLLYLL---ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGF 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 180 HSVFVV-MGIAGILLAVIWLKTVYEPKKHPKVNEAELAYIEqgggLISMddskskqeteskwpyiKQLLTNRMLIGVYIA 258
Cdd:cd17489  150 AVLFIVaAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRR----LVEK----------------KVLPPALILFLASIA 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 259 QYCITTLTyffltwfPVYlVQARGMSilEAGFVASLPALCGFAGGVLGGIVSDillKKGRsltfaRKVPIIAGMLLSCSM 338
Cdd:cd17489  210 YGAISTFL-------PLY-AAERGIS--NAGLFFTVYAIALLLSRPFSGKLSD---RKGP-----KTVIIPGLLLLALGL 271
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 339 IVCNYTDSAWLVVVimSLAFFGKGFGAL---GWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGsFNGA 415
Cdd:cd17489  272 LLLSFAGSPWMLLL--AAVLYGLGFGLLfpaLQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG-YRAM 348
                        410
                 ....*....|....*....
gi 402479673 416 LVFVGANAIAAILSYLLLV 434
Cdd:cd17489  349 FLLAAVVVLLALVLYIFLL 367
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
19-428 3.55e-15

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 76.91  E-value: 3.55e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  19 WFIVFMLFLVTSInyadratLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFF 98
Cdd:cd17341    5 WLSFFLGFMVWFL-------FAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIP 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  99 TLlqgaiGFFSAGTAIILLFALRFLVGLSEApSFPGNGRVVASWFPSSERGTASA-------FFNSAQYFAIVIFSPLMG 171
Cdd:cd17341   78 LL-----ALALAVSSYWGLLVLGFLLGFAGA-NFASGQPWASFWFPKEKIGGAAGgiagagnMGVAVSQLLAPLIAGAIV 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 172 WLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYIEQGgglismddSKSKQETESKWPYIkqlltnrM 251
Cdd:cd17341  152 FDGGFVGWRNAFFVPGILLAIAAVLVLLFGDDLPTGKASALEFLKVQLAV--------LKNYRTWILSLLYG-------V 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 252 LIGVYIAqycittltyfFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILlkKGRSLTFARKVPIIAG 331
Cdd:cd17341  217 TFGSFVG----------FSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRF--GGRRRLWWLFIVMTIG 284
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 332 MLLsCSMIVCNYTDSAWLVVVIMSLAFFGKGFG-ALGWAVVSDTSPKEcAGLSGGLFNTFGNIASITTPIIIGYIVNATG 410
Cdd:cd17341  285 AAL-LSLSLPTSGTNLVLFLALFVALGLGAGAGnGSVFRMVPFIFRRE-LGAVTGLVGAIGGLGGFFLPLLFGSSALMTG 362
                        410
                 ....*....|....*...
gi 402479673 411 SFNGALVFVGANAIAAIL 428
Cdd:cd17341  363 SGVGAFSLFGVLAVACTL 380
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
22-433 2.40e-14

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 74.16  E-value: 2.40e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  22 VFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLL 101
Cdd:cd17365    1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 102 QGAigffsaGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHS 181
Cdd:cd17365   81 TAF------AQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRS 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 182 VFVVMGIAGILLAVIWLKTVyepkkhpkvneaelayieqggglismddskskqeteskwpyikqlltnrMLIGVYIaqyC 261
Cdd:cd17365  155 VFLLGGVPPLILLPLLRGTL-------------------------------------------------LLWVTFF---M 182
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 262 ITTLTYFFLTWFPvYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDillkkgrslTFARKVPIIAGMLLSCSMIVC 341
Cdd:cd17365  183 GLLLVYLLNSWLP-KLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLAD---------RFGPKRVLALFFALGAVSLAL 252
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 342 ---NYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALVF 418
Cdd:cd17365  253 lgvSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLA 332
                        410
                 ....*....|....*
gi 402479673 419 VGANAIAAILSYLLL 433
Cdd:cd17365  333 LAIPAALGALAVLLL 347
glpT PRK11273
glycerol-3-phosphate transporter;
57-447 2.44e-14

glycerol-3-phosphate transporter;


Pssm-ID: 236889 [Multi-domain]  Cd Length: 452  Bit Score: 74.75  E-value: 2.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  57 MGYVFSAFGWAYVIGQLPGGWLLDRFGSKtiialsiFFWSFFTLLQGAIGFFS-----AGTAIILLFALRFLVGLSEAPS 131
Cdd:PRK11273  65 LGFALSGISIAYGFSKFIMGSVSDRSNPR-------VFLPAGLILAAAVMLFMgfvpwATSSIAVMFVLLFLCGWFQGMG 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 132 FPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPL----MGWLTHsfgWHSVFVVMGIAGILLAVIWLKTVYEPKKH 207
Cdd:PRK11273 138 WPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLPPLLfllgMAWFND---WHAALYMPAFAAILVALFAFAMMRDTPQS 214
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 208 ---PKVNEAELAYIEQGgglismdDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMS 284
Cdd:PRK11273 215 cglPPIEEYKNDYPDDY-------NEKHEQELTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFA 287
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 285 ILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFarkvpiIAGMLLSCSMIVCNYTDSAWLVVVIMsLAFFGKGFG 364
Cdd:PRK11273 288 LDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGNRGATG------VFFMTLVTIATIVYWLNPAGNPTVDM-ACMIVIGFL 360
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 365 ALGWAVVS-----DTSPKECAGLSGGLFNTFGNI-ASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIK 438
Cdd:PRK11273 361 IYGPVMLIglhalELAPKKAAGTAAGFTGLFGYLgGSVAASAIVGYTVDFFGWDGGFMVMIGGSILAVILLIVVMIGEKR 440

                 ....*....
gi 402479673 439 RVVLKKQEQ 447
Cdd:PRK11273 441 HHEELLQKR 449
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
45-433 2.93e-14

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 73.76  E-value: 2.93e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  45 SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFtllqGAIGFFSAGTAIILLFalRFLV 124
Cdd:cd17474   24 AIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIG----GLLCGLSDSFALLLAG--RALQ 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 125 GLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIfSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEP 204
Cdd:cd17474   98 GIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAV-GPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEP 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 205 KKHPKvneaelayieqggglismddsKSKQETESKWpyiKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMS 284
Cdd:cd17474  177 KEKAK---------------------SSSATKLRDL---KKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGIS 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 285 ILEAGFVASLPALCGFAGGVlggIVSDILLKKGRsltfARKVPIIAGMLLSCSMIVCNYTDSAWLVVVImsLAFFGKGFG 364
Cdd:cd17474  233 PIIIGLLFAGWSVLLALGSL---FVGRLLKKRFG----ARRILVIGLLLYALSLLLLGFVPSLALLLIA--IVLFGLGLG 303
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 402479673 365 ---ALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVnatGSFNGALVFVGANAIAAILSYLLL 433
Cdd:cd17474  304 lnlPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLL---EIFGLSAPFLVGAAIALAAAVLLA 372
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
19-431 7.03e-14

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 72.74  E-value: 7.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  19 WFIVFMLFLVTsinyadrATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFf 98
Cdd:cd17333    2 YISFFSNGLTD-------ALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISL- 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  99 tllqGAIGFFsAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTAS---AFFNSAQYFAIVIFSPLmgwLTH 175
Cdd:cd17333   74 ----ALALIF-ATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNvlhGFFGLGALIGPLIATSL---LTS 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 176 SFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHpkvneaelayieqggglismdDSKSKQETESKWPYIKQLLTNRMLIGV 255
Cdd:cd17333  146 ELSWSWAYLIIGLIYLLLAILILLTLFPELPS---------------------ARNPQQSVGAFSASASRLLRNPSIILG 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 256 YIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSdillkkgRSLTFARKVPIIAGMLLS 335
Cdd:cd17333  205 ALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPIS-------RRIKPHTLLVLSGSGALL 277
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 336 CSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKEcAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGA 415
Cdd:cd17333  278 GLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYA-KGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAM 356
                        410
                 ....*....|....*.
gi 402479673 416 LVFVGANAIAAILSYL 431
Cdd:cd17333  357 LLITILYAIIFVLALL 372
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
50-437 1.50e-13

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 72.24  E-value: 1.50e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  50 LGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKT-----IIALSIFFWSFFTLLQGAIGFFSAGTAIILLFALRFLV 124
Cdd:COG2211   41 LGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLL 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 125 GLSEAPSFPGNGRVVASWFPSS-ERGTASAFFNSAQYFAIVIFSPLMGWLTHSF------GWHSVFVVMGIAGILLAVIW 197
Cdd:COG2211  121 GLAYTLVNIPYSALGAELTPDYeERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLT 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 198 LKTVYEPKKHPKvneaelayieqggglismddskskqETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYL 277
Cdd:COG2211  201 FFGTKERPVPEE-------------------------EKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYF 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 278 VQARGMSILEAGFVASLPALCGFAGGVLGGIVSDIllkkgrsltFARKVPIIAGMLLSCSMIVCNY---TDSAWLVVVIM 354
Cdd:COG2211  256 KYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR---------FGKKKAFIIGLLLAALGLLLLFflgPGNLWLLLVLA 326
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 355 SLAFFGKG-FGALGWAVVSDTSP-------KECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALvfVGANAIAA 426
Cdd:COG2211  327 ALAGIGLGaILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAA--QSPSALTG 404
                        410
                 ....*....|.
gi 402479673 427 ILSYLLLVGPI 437
Cdd:COG2211  405 IRLLFFLLPAV 415
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
19-431 5.37e-13

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 69.99  E-value: 5.37e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  19 WFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIffwSFF 98
Cdd:cd17355    2 WVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGL---LLL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  99 TLLQGAIGFFSAGTAIILLFALrfLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFG 178
Cdd:cd17355   79 AAGLVLLALATSLWQLYLLWGL--LGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFG 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 179 WHSVFVVMGIAGILLAVI-WLKTVYEPKKHPKVNEAELAYIEQGGGLismddskskqeteskwpyiKQLLTNRMLIGVYI 257
Cdd:cd17355  157 WRTALLVLALLALLVLVPvLLLLRRRPADLALRAYDDASPASPGSTL-------------------KEALRSASFWLLAL 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 258 AQYCITTLTYFFLTWFPVYLVQaRGMSILEAGFVASLPALCGFAGGVLGGIVSDillkkgrsLTFARKVPIIAGMLLSCS 337
Cdd:cd17355  218 AFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFNIVGRLLSGWLGD--------RYSPRRLLAASYALRALG 288
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 338 MIVCNYTDSA--WLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGA 415
Cdd:cd17355  289 LALLLLLPFPplALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAA 368
                        410
                 ....*....|....*.
gi 402479673 416 LVFVGANAIAAILSYL 431
Cdd:cd17355  369 WALAVALGLIAALLVL 384
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
38-432 9.10e-12

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 66.48  E-value: 9.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  38 TLSITGDSVQH--------DLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSiFFWSFFTLLQGAIGFFS 109
Cdd:cd06173    9 LLSALGDWIFTvalpwlvlQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILA-DLLRALLAAVLALLALL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 110 AGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGIA 189
Cdd:cd06173   88 GSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALS 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 190 GILLAVIWLKTVYEPKKHPKvneaelayieqggglismddSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFF 269
Cdd:cd06173  168 FLLSALLLLFIRRPPPAAPG--------------------ESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGAL 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 270 LTWFPVYLVQARGMSILEAGFVASLPALcgfaGGVLGGIVSDILLKKGRSltfaRKVPIIAGMLLSCSMIVCNYTDSAWL 349
Cdd:cd06173  228 TVLLPLLAKEVLGGGAAGYGLLLAAFGV----GALLGALLLGRLSKRRRR----GRLLLIGALLLGLALLVLGLSPSLWL 299
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 350 VVVIMSLAFFGKGFGALGW-AVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAIAAIL 428
Cdd:cd06173  300 LLAALFLLGLAGGLFNVPLnTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALL 379

                 ....
gi 402479673 429 SYLL 432
Cdd:cd06173  380 LLLL 383
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
46-434 2.47e-10

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 61.82  E-value: 2.47e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  46 VQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWsfftllqgAIGFFSAGTA--IILLFALRFL 123
Cdd:cd17320   25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLF--------ILASLLCALAssIEQLLIARFL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 124 VGLSEAPsfpgnGRVVA-----SWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWL 198
Cdd:cd17320   97 QGLGAAA-----GSVVAraivrDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVL 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 199 KtvYEPKKHPKvneaelayieqggglismddSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLV 278
Cdd:cd17320  172 L--FLPETLPE--------------------EKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYI 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 279 QARGMSILEAGFVASLPALcgfaGGVLGGIVSDILLKKGRSLTFARkVPIIAGMLLSCSMIVCNYT--DSAWLVVVIMSL 356
Cdd:cd17320  230 EQLGLSPAQFGLLFALNAI----ALILGSLLNGRLVRRFGPRRLLR-LGLLLLLAAALVLLLAALLggLSLWPLVAPLFL 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 357 AFFGKGF---GALGWAVVSDtspKECAGLSGGLFNTFGNIASITTPIIIGYIVNatgsfNGALVFVGANAIAAILSYLLL 433
Cdd:cd17320  305 IFFGFGLifpNATSLALEPF---PHVAGTASALLGFLQFLIGALAGALVGLLPN-----GTALPMGLLILVLGLLALLLL 376

                 .
gi 402479673 434 V 434
Cdd:cd17320  377 I 377
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
48-436 3.33e-10

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 61.52  E-value: 3.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  48 HDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWsfftllqgaiGFFSAGTAII----LLFALRFL 123
Cdd:PRK11551  43 QEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALF----------GLFSLATAQAwdfpSLLVARLL 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 124 VGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGIAGIL---LAVIWLKt 200
Cdd:PRK11551 113 TGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLlvpLLMRWLP- 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 201 vyepkkhpkvneAELAYIEQggglismddSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVqA 280
Cdd:PRK11551 192 ------------ESRAFAQA---------AGAGKQRAPVLRALFGEGRATATLLLWISYFFTLIVLYFLLNWLPSLLV-G 249
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 281 RGMSILEAGFVASLPALCGFAGGVLGGIVSDiLLKKGRSLTFarkvpIIAGMLLSCSMIvcnytdSAWLVVVIMSLAFFG 360
Cdd:PRK11551 250 QGLSRSQAGLVQIAFNIGGALGSLLIGALMD-RLRPRRVVLL-----IYAGILASLAAL------AAAPSFAGMLLAGFA 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 361 KGFGALG-----WAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSfngALVFVGAN----AIAAILSYL 431
Cdd:PRK11551 318 AGLFVVGgqsvlYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLLALGRS---TVGVIGASipviLVAALAALL 394

                 ....*
gi 402479673 432 LLVGP 436
Cdd:PRK11551 395 LVSRP 399
MFS_UhpC cd17488
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ...
18-433 5.68e-10

Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341041 [Multi-domain]  Cd Length: 364  Bit Score: 60.88  E-value: 5.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  18 RWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSF 97
Cdd:cd17488    1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  98 FTLLqgaigfFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSF 177
Cdd:cd17488   81 INIL------FGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTY 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 178 GWHSVFVVMGIAGILLAvIWLktVYEPKKHPkvneaelayieqggglismddskskqeteskwPYIKQLLTNRMLigVYI 257
Cdd:cd17488  155 GWRAGMYVPGIIAILMG-IVL--CWRLRDRP--------------------------------PYIWLLAFCYVL--VYV 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 258 AQYCITtltyfflTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGR---SLTFArkvpiiAGMLL 334
Cdd:cd17488  198 VRTAIN-------DWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFKGNRgpmNLIFA------LGLLV 264
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 335 SCSMIVCNYTDSAWLVVVIM-SLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGsFN 413
Cdd:cd17488  265 SVGALWLVPVHSYWLLATCFfTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLGAALAGYPLAKVIESWG-WS 343
                        410       420
                 ....*....|....*....|
gi 402479673 414 GALVFVGANAIAAILSYLLL 433
Cdd:cd17488  344 GFFIVISIAAAISGLLLLPL 363
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
47-425 7.23e-10

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 60.28  E-value: 7.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  47 QHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQGAigffsAGTAIILLFAlRFLVGL 126
Cdd:cd17503   23 MGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL-----APNLASLIIF-RILQGF 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 127 SEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIwlktvyepkk 206
Cdd:cd17503   97 GGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL---------- 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 207 hpkvneaelayieqgGGLISMDdskskqeteskwpyikqLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSIL 286
Cdd:cd17503  167 ---------------APLLDLR-----------------LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAF 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 287 EAGFVASLPALCGFAGGVLGGIVSDillkkgrslTFARKVPIIAGMLL---SCSMIVCNYTDSAWLVVVIMsLAFFGKGF 363
Cdd:cd17503  215 ESGLVLAPGGLASAILSPLVGRLLD---------KFGPRLLLLAGLLLlalGTLLLAFLTPDTSLWLIILP-LFIRGLGM 284
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 402479673 364 GAL-----GWAVVSdtSPKECAGLSGGLFNTFGNIA-SITTPIIIGYIVNATGSFNGALVFVGANAIA 425
Cdd:cd17503  285 GLVfmplnTLALNS--LPPEQIGDATALFNTIRQLGgSIGTALLATLLTNRTQFHHSRLSELLAQQVQ 350
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
18-432 1.25e-09

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 59.93  E-value: 1.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  18 RWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWsf 97
Cdd:cd17353    1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILF-- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  98 ftllqgAIGFFSAGTAI---ILLFALRFLVGLSEAPSFPGNGRVVASWFPSsERGTASAFFNSAQYFAIVIFSPLMGWLT 174
Cdd:cd17353   79 ------GLGFILSAFAIslpLLFLGYGVLGGIGAGIGYITPVSTAVKWFPD-KRGLATGIVIAGFGLGSLIFSPLIAYLI 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 175 HSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAyieqggglismddsKSKQETESKWPYIKQLLTNRMLIG 254
Cdd:cd17353  152 NTVGVPTTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPL--------------ANNAENSPRDYTPREMLRTPTFWL 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 255 VYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDillKKGRSLTFarkvpIIAGMLL 334
Cdd:cd17353  218 LWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSD---KIGRKNTL-----SIAFLIQ 289
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 335 SCSMIVCNYT-DSAWLVVVIMSLAFFGKGFG-ALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNaTGSF 412
Cdd:cd17353  290 GVAMFLLPFIgSVAVLFVLGVALIGFCYGGGfALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLY-TGGY 368
                        410       420
                 ....*....|....*....|.
gi 402479673 413 NGALVFVGA-NAIAAILSYLL 432
Cdd:cd17353  369 NAAFIIAAAlSLVALALALLL 389
PRK12307 PRK12307
MFS transporter;
46-435 2.23e-09

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 59.17  E-value: 2.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  46 VQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQGAigffsaGTAIILLFALRFLVG 125
Cdd:PRK12307  44 IKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGL------ASGVIMLTLSRFIVG 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 126 LSEAPSFP-GNGRVVASWfPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVmGIAGILLaVIWLKtvyep 204
Cdd:PRK12307 118 MGMAGEYAcASTYAVESW-PKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFV-GLLPVLL-VIYIR----- 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 205 KKHPKVNEAELAYIEqggglismDDSKSKQETESKWPYIKQLLTNR----MLIGVYIAQYCITTLTYFFLTWFPVYLVQa 280
Cdd:PRK12307 190 ARAPESKEWEEAKLS--------GKGKHSQSAWSVFSLSMKGLFNRaqfpLTLCVFIVLFSIFGANWPIFGLLPTYLAG- 260
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 281 rgmSILEAGFVASLPALCGFaGGVLGGIVSDILLKK-GRSLTFArkVPIIAGMLLSCSMIVCNYTDSAWLVVVIMSLAFF 359
Cdd:PRK12307 261 ---EGFDTGVVSNLMTAAAF-GTVLGNIVWGLCADRiGLKKTFS--IGLLMSFLFIFPLFRIPQDNYLLLGACLFGLMAT 334
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 402479673 360 GKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGsFNGALVFVGANAIAAIlsyLLLVG 435
Cdd:PRK12307 335 NVGVGGLVPKFLYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWLGITMG-LGAALTFIVAFWTATI---LLIIG 406
PRK11663 PRK11663
glucose-6-phosphate receptor/MFS transporter UhpC;
20-433 3.47e-09

glucose-6-phosphate receptor/MFS transporter UhpC;


Pssm-ID: 183266 [Multi-domain]  Cd Length: 434  Bit Score: 58.57  E-value: 3.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  20 FIVFMLFLVT--SINYADRATLSitgdsvqhDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSF 97
Cdd:PRK11663  29 YLGYALFYFTrkSFNAAMPEMLA--------DLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGI 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  98 FTLLqgaIGFFSAGTAIILLFALR-FLVGLSeapsFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHS 176
Cdd:PRK11663 101 INIL---FGFSSSLWAFALLWVLNaFFQGWG----WPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALH 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 177 FGWHSVFVVMGIAGILLAVI--W-LKTVYEPKKHPKV-----NEAELAYIEQGGGLismddskSKQETESKW----PYIK 244
Cdd:PRK11663 174 YGWRYGMMIAGIIAIVVGLFlcWrLRDKPQAMGLPSVgewrhDALELAQQQEGAGL-------SRKEILTKYvllnPYIW 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 245 QLLTNRMLigVYIAQYCITtltyfflTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGR---SLT 321
Cdd:PRK11663 247 LLSFSYVL--VYVVRAAIN-------DWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLFNGNRgpmNLI 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 322 FArkvpiiAGMLLSCSmivcnytdSAWLV----VVIMSLAFFGKGFGALGWAVV-----SDTSPKECAGLSGGLFNTFGN 392
Cdd:PRK11663 318 FA------AGILLSVG--------SLWLMpfasYVMQAACFFTIGFFVFGPQMLigmaaAECSHKEAAGAATGFVGLFAY 383
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 402479673 393 IASITTPIIIGYIVNaTGSFNGALVFVganAIAAILSYLLL 433
Cdd:PRK11663 384 LGAALSGYPLAKVLE-IWHWTGFFVVI---SIAAGISALLL 420
PRK12382 PRK12382
putative transporter; Provisional
58-199 4.61e-09

putative transporter; Provisional


Pssm-ID: 183487 [Multi-domain]  Cd Length: 392  Bit Score: 58.15  E-value: 4.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  58 GYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSiffwsfftLLQGAIGFFSAGTAIILLFAL--RFLVGLSEAPSFPGN 135
Cdd:PRK12382 252 GFTLTAFGGAFVLMRVLFGWMPDRFGGVKVAIVS--------LLVETVGLLLLWLAPTAWVALagAALTGAGCSLIFPAL 323
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 402479673 136 GRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGIA---GILLAVIWLK 199
Cdd:PRK12382 324 GVEVVKRVPSQVRGTALGGYAAFQDIAYGVSGPLAGMLATSFGYPSVFLAGAISavlGIIVTILSFR 390
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
17-196 4.76e-09

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 57.61  E-value: 4.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  17 VRWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWS 96
Cdd:cd17316  175 LRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSG 254
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  97 FFTLLQGAIGFFSAGTAIILLFALRFLVGLSEAPSfpgnGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHS 176
Cdd:cd17316  255 ILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGAL----YAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAS 330
                        170       180
                 ....*....|....*....|
gi 402479673 177 FGWHSVFVVMGIAGILLAVI 196
Cdd:cd17316  331 TGGTGVPALILALLAIVALI 350
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
13-200 9.35e-09

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 56.81  E-value: 9.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  13 KKTSVRWFIVFMlFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLD-RFGSKTIIALS 91
Cdd:cd17474  193 KALRGRGLLTFL-VSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKkRFGARRILVIG 271
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  92 IFFwsfFTLLQGAIGFFsagTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMG 171
Cdd:cd17474  272 LLL---YALSLLLLGFV---PSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFG 345
                        170       180
                 ....*....|....*....|....*....
gi 402479673 172 WLTHSFGWHSVFVVMGIAGILLAVIWLKT 200
Cdd:cd17474  346 LLLEIFGLSAPFLVGAAIALAAAVLLALL 374
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
18-420 2.39e-08

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 55.88  E-value: 2.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  18 RWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSF 97
Cdd:cd17314    1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  98 FTLLQGAigffsAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSeRGTASAFFNSAQYFAIVIFSPLMGWLTHSF 177
Cdd:cd17314   81 GYTYLSY-----VFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDT-KGLALGLPTTGYSLGLVLGSPLLRILWVFY 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 178 GWHSVFVVMGIAgiLLAVIWLKTVYEPKKHPKVNEAELAYieqGGGLISMDDSKSKQETESKWPYIKQLLTNRMLIGVYI 257
Cdd:cd17314  155 GLALVYTILGIL--AAIVLSVVSLLGFKEPPDNQARLHVQ---KKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANM 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 258 AQYcittltyffltwfpvylvqARGMSILEAGFVA---SLPALCGFAGGVLGGIVSDILLKKGRSLTFarkVPIIAGMLL 334
Cdd:cd17314  230 ASL-------------------VRSLQLDAPSFVTklmSIYGLFNAFGRLLWGIVADFFGGRLSTLSI---LLTILGLGL 287
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 335 SCSMIVCNYTDSaWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNG 414
Cdd:cd17314  288 CAFLFLLKMTPV-GLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYIS 366

                 ....*.
gi 402479673 415 ALVFVG 420
Cdd:cd17314  367 AVYIYA 372
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
47-209 3.55e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 55.27  E-value: 3.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  47 QHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIialsiFFWSFFTLLQGAIGFFSAGTAIILLFALRFLVGL 126
Cdd:COG2223  233 VDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRV-----LLIVFALMALGLLLLALALGSLWLFLVLFLLLGL 307
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 127 SEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFG-WHSVFVVMGIAgILLAVIWLKTVYEPK 205
Cdd:COG2223  308 ALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVL-ALVALVLTLLLYRRP 386

                 ....
gi 402479673 206 KHPK 209
Cdd:COG2223  387 RRAA 390
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
17-235 4.82e-08

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 55.08  E-value: 4.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673   17 VRWFIVFMLFLVTSInyADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKtiialSIFFWS 96
Cdd:TIGR00711   1 LLLTIVLMLGTFMAV--LDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTR-----RLFLIS 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673   97 FFTLlqgAIGFFSAGTA--IILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLT 174
Cdd:TIGR00711  74 TFAF---TLGSLLCGVApnLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWII 150
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 402479673  175 HSFGWHSVFVVMGIAGILLAVIWLKTVYE--PKKHPKVNEAELAYIEQGGGLISMDDSKSKQE 235
Cdd:TIGR00711 151 ENYHWRWIFLINVPIGIIVVVVAFFILPRdkPAASENFDFLGLLLLSVGLGSLLYGLSEGPER 213
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
47-198 1.19e-07

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 53.71  E-value: 1.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  47 QHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFfwsfftLLQGAIGFFSAGTAIILLFALRFLVGL 126
Cdd:cd17324  226 TDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLL------LAAALLLLTLLGPSPLLLLVGLVLWGL 299
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 402479673 127 SEAPSFPGNGRVVASWFPSSeRGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWL 198
Cdd:cd17324  300 GFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
19-433 1.37e-07

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 53.33  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  19 WFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFF 98
Cdd:cd17352    2 WVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  99 TLLQgaigfFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFpSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFG 178
Cdd:cd17352   82 LLLS-----SFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYG 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 179 WHSVFVVMGIAGILLAVIWLktvyepkkhpkvneaelayieqggglismddskskqeteskwpyIKQLLTNRM----LIG 254
Cdd:cd17352  156 WRGALLILGGLCLNLCVCGL--------------------------------------------LLRLLKDPTfvllALG 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 255 VYIAQYCITTLTYFFltwfPVYLVQaRGMSILEAGFVASLPALCGFAGGVLGGIVSDilLKKGRSLTFARKVPIIAGMLL 334
Cdd:cd17352  192 VSFAMLGFFVPFVYL----PSYAKS-LGIDESDAAFLLSIIGISDIVGRILLGLLAD--KPRIGRLYLYIFTLLILGLSL 264
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 335 SCSMIVCNYTdsawlVVVIMSLAF-FGKG-FGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSF 412
Cdd:cd17352  265 LAFPLATTYV-----GLIVFSVLFgFCSGsYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDY 339
                        410       420
                 ....*....|....*....|.
gi 402479673 413 NGALVFVGANAIAAILSYLLL 433
Cdd:cd17352  340 DAAFYFCGACLLLSGVLLFLL 360
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
46-206 1.42e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 53.32  E-value: 1.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  46 VQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLqgaigFFSAGTAIILLFALrFLVG 125
Cdd:COG0738  237 LKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLL-----ALLAPGPWLALIGL-ALVG 310
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 126 LSEAPSFPGNGRVVASWFPSSERGTASAFFNSAqYFAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPK 205
Cdd:COG0738  311 LGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMG-IVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRR 389

                 .
gi 402479673 206 K 206
Cdd:COG0738  390 K 390
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
19-198 1.43e-07

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 53.32  E-value: 1.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  19 WFIVFMLFLVTsINYADRATLSITGdsvqHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFF 98
Cdd:cd17370  203 WLYLLAVALFA-LGNFSFAFLILRA----QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALA 277
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  99 TLLqgaIGFFSAGTAIILLFALRFL-VGLSEapsfpGNGR-VVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHS 176
Cdd:cd17370  278 YLG---FALGSSLWLLLLGFILWGLyMGAQE-----SIERaAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDL 349
                        170       180
                 ....*....|....*....|..
gi 402479673 177 FGWHSVFVVmGIAGILLAVIWL 198
Cdd:cd17370  350 ISPSAAFLF-SAVLALIALLLL 370
PRK03699 PRK03699
putative transporter; Provisional
57-433 2.38e-07

putative transporter; Provisional


Pssm-ID: 235151 [Multi-domain]  Cd Length: 394  Bit Score: 52.62  E-value: 2.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  57 MGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSiffwsFFTLLQGAIGFFSAGTAIILLFALrFLVGLSEAPSFPGNG 136
Cdd:PRK03699  44 MSNTFTFLNAGILISIFLNAWLMEIIPLKRQLIFG-----FALMILAVAGLMFSHSLALFSIAM-FVLGVVSGITMSIGT 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 137 RVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGW-LTHSFGWHSVFVVMGIAGILLAVIWLKTVYepkkhPKVNEAEl 215
Cdd:PRK03699 118 FLITHVYEGKQRGSRLLFTDSFFSMAGMIFPIIAAYlLARSIEWYWVYACIGLVYVAIFILTLFSEF-----PALGKHA- 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 216 ayieqggglismdDSKSKQETESKWpyikqlltNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASlp 295
Cdd:PRK03699 192 -------------PKADKPVAKEKW--------GIGVLFLAIAALLYILAQLTFISWVPEYAQKKFGMSLEDAGNLVS-- 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 296 alcGFAGG-VLGGIVSDILLKKGRSLTFarkVPIIAGMLLSCSMIVCNYTDSAWLVVVIMSLAFFG----KGFGALGWAV 370
Cdd:PRK03699 249 ---NFWMAyMVGMWIFSFIVRFFDLQRI---LTVLAGLALVLMYLFVNTDDPSHLLYAILGLGFFSsaiyTTIITLGSQQ 322
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 402479673 371 VSDTSPKecaglsggLFN---TFGNIASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLL 433
Cdd:PRK03699 323 TKVASPK--------LVNfilTCGTIGTMLTFVVTSPIVAHFGLQAALLTANGLYAVVFVMCILLG 380
MFS_1 pfam07690
Major Facilitator Superfamily;
22-167 3.01e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 52.04  E-value: 3.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673   22 VFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFfwsFFTLL 101
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALL---LLILA 278
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 402479673  102 QGAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFS 167
Cdd:pfam07690 279 ALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
44-364 3.36e-07

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 52.19  E-value: 3.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  44 DSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTllqgaIGFFSAGTaIILLFALRFL 123
Cdd:cd17323   23 PQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQ-----IGCALAPN-IAMLIILRFL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 124 VGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVF-VVMGIAGILLAVIWLktvy 202
Cdd:cd17323   97 QGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFwFLAIISGFCLILIFL---- 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 203 epkkhpkvneaelayieqggglismddskskqeteskwpyikqLLTNRMLIGVYIA-QYCIttlTYFFLTWFPVYLVQAR 281
Cdd:cd17323  173 -------------------------------------------FLPIVLLLGLYVGlVYAI---LYLFLTAFPYVFGEVY 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 282 GMSILEAGFVASLPALCGFAGGVLGGIVSDILLKK------GRSLTFARKVPIIAGMLLSCSMIV----CNYTDSAWLVV 351
Cdd:cd17323  207 GFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRlkkkngGKPEPEARLPPAFIGAFLFPIGLFifgwTIYPHIHWIVP 286
                        330
                 ....*....|...
gi 402479673 352 VIMSlAFFGKGFG 364
Cdd:cd17323  287 IIGS-AFFGFGLM 298
MFS_1 pfam07690
Major Facilitator Superfamily;
255-446 7.02e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 50.88  E-value: 7.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  255 VYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDIllkkgrsltFARKVPIIAGMLL 334
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR---------FGRRRVLLIGLLL 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  335 SCSMIVC--NYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSF 412
Cdd:pfam07690  72 FALGLLLllFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWR 151
                         170       180       190
                  ....*....|....*....|....*....|....
gi 402479673  413 NGALVFVGANAIAAILSYLLLVGPIKRVVLKKQE 446
Cdd:pfam07690 152 AAFLILAILSLLAAVLLLLPRPPPESKRPKPAEE 185
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
48-434 9.14e-07

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 50.69  E-value: 9.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  48 HDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLqgaIGFFSagtAIILLFALRFLVGLS 127
Cdd:cd17329   28 QQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFAL---LGFAH---SPWLFAIALVLTGFG 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 128 EAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWL-THSFGWhsVFVVMGIAGILLAVIWLKTVYEPKK 206
Cdd:cd17329  102 GGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLlLYSFRL--LFLAAAVLFLLAALVLLFLLPETRP 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 207 HPKVNEaelayieqggglismddskskqETESKWPYiKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSIL 286
Cdd:cd17329  180 KRRAAE----------------------KTEILRGY-KIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGES 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 287 EAGFvasLPALCGFAGGVLGGIVSDILLKKGRSLTfarkvpIIAGMLL-SCSMIVCNYTDSAWLVVVIMSLAFFGKGFGA 365
Cdd:cd17329  237 LLGL---LLALNALLIVLLQFPVARLVERFRLRKI------LMIGILLfAIGFAVLAFANTLAVLILAMIVLTLGEMLVF 307
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 366 LGW-AVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGsFNGALVFVGANAIAAILSYLLLV 434
Cdd:cd17329  308 PAVqTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLG-PGLPWLILAALGLIAAALLLGLQ 376
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
252-449 1.49e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 50.30  E-value: 1.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 252 LIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDIllkkgrsltFARKVPIIAG 331
Cdd:cd17329    1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADR---------FGRKPVMLAG 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 332 MLLS-CSMIVCNYTDSAWLVVVIMSLAFFGKG-FGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNat 409
Cdd:cd17329   72 LLLRaLGFALLGFAHSPWLFAIALVLTGFGGGlFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-- 149
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 402479673 410 gsFNGALVFVgANAIAAILSYLLLVGPIKRVVLKKQEQDP 449
Cdd:cd17329  150 --YSFRLLFL-AAAVLFLLAALVLLFLLPETRPKRRAAEK 186
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
47-196 1.62e-06

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 49.86  E-value: 1.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  47 QHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLqgaIGFFSAGTAIILLFALRFLVGL 126
Cdd:cd17321  196 QGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLL---LALLGADSSVWLLLPGLVLLGL 272
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 127 SEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY----FAIVIFSPLMGWLTHSF-------------------GWHSVF 183
Cdd:cd17321  273 GLGLFATPLTNAALSSVPKEKAGAASGILNTARQlggaLGVALLGALLTAGLSANlgdsgvaallsaaaaafaaGFHLAF 352
                        170
                 ....*....|...
gi 402479673 184 VVMGIAGILLAVI 196
Cdd:cd17321  353 LVAAALALLAALL 365
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
50-197 1.72e-06

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 49.86  E-value: 1.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  50 LGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIffwsfFTLLQGAIGFFSAGTAIILLFALRFLVGLSEA 129
Cdd:cd17477  218 LGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCA-----LLGALAALLLPLVPGLPLALLVLLFLWGGAAG 292
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 402479673 130 PSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIW 197
Cdd:cd17477  293 PLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
37-198 2.88e-06

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 49.11  E-value: 2.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  37 ATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQgAIGFFSAGTAIIL 116
Cdd:cd17320  219 AYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVL-LLAALLGGLSLWP 297
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 117 LFALRFLVGLSEAPSFPGNGRVVASWFPsSERGTASAFFNSAQYFAIVIFSPLMGWLtHSFGWHSVFVVMGIAGILLAVI 196
Cdd:cd17320  298 LVAPLFLIFFGFGLIFPNATSLALEPFP-HVAGTASALLGFLQFLIGALAGALVGLL-PNGTALPMGLLILVLGLLALLL 375

                 ..
gi 402479673 197 WL 198
Cdd:cd17320  376 LI 377
MFS_YdiM_like cd17396
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ...
38-430 4.17e-06

Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340954 [Multi-domain]  Cd Length: 384  Bit Score: 48.88  E-value: 4.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  38 TLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLlqgAIgFFSAGTAIILL 117
Cdd:cd17396   18 ILAQNMSSLSEKWHTDVAGVAYVISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALFFV---GI-LFSPNLIIAYV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 118 FAlrFLVGLSEAPSFPGNGRVVASWFPSSErGTAS----AFFNSAQYFAIVIFSPLMgWLTHSFGWhsVFVVMGIAGILL 193
Cdd:cd17396   94 FA--LLAGAANSFLDTGTYPALMEAFPKAS-GSANilvkAFVSFGQFLLPFIIAFLA-ANNLWYGW--SFIVPAAVLVLN 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 194 AVIWLKTVYEPKKHPKVNEAelayieqggglismddsksKQETESKWPYIKQLLTNRMLIgvyIAQYCITTLTYFFLTWF 273
Cdd:cd17396  168 ALLLLKLSFPPQTVTAANTK-------------------QKEIPVKREKPKFLIEGIALI---LIGFTSTATFYLFSQWM 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 274 PVYLVQARGMSILEAGFVASLPALcgfaGGVLGGIVSDILLKKG-RSLTFARKVPIIAGMLLscsMIVCNYTDSAwlvvV 352
Cdd:cd17396  226 PKYGSAVAGMGEAESLKLISYYSM----GSLVCVFITAVLLKRYvRPIWILVLYPIISLLAL---FVLYLVPSPD----V 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 353 IMSLAFFGKGFGA-----LGWAVVSDTSPKEcAGLSGGLFNTFGNIASITTPIIIGYIVNATG-----SFNGALVFVGAn 422
Cdd:cd17396  295 CILGAFVIGFFAAggvlqLGLTLMAEFFPKG-KGKVTGIYMIASSLANFVIPLITGIIASAIGiayifLFDFGIALLGL- 372

                 ....*...
gi 402479673 423 AIAAILSY 430
Cdd:cd17396  373 LLAIFVFI 380
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
58-428 6.59e-06

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 47.98  E-value: 6.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  58 GYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFwsfftLLQGAIGFFSAGTAIILLFAlRFLVGLSEAPSfpgngr 137
Cdd:cd17472   35 GLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLL-----FIAGSLLAAYATSIYGLILG-RALQGSGAISS------ 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 138 VVASWF----PSSERGTASAF---FNSAQYFAIVIFSPLmgwLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHpkv 210
Cdd:cd17472  103 VVMALLadltREENRTKAMALigaSIGIAFAISMVLGPL---LAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKI--- 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 211 neaelayieqggglismddsksKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILEagF 290
Cdd:cd17472  177 ----------------------VQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQL--W 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 291 VASLPALcgFAGGVLGGIVSDILLKKGR-SLTFarkVPIIAGMLLSCSMIVCNYTDsawLVVVIMSLAFFGKGFG---AL 366
Cdd:cd17472  233 KVYLPAI--LIGFILMVPFVIYAEKKGKmKQVF---VSSILLIAVGFLLLLFAATS---LWLLIIGLIIFFIGFNlleAL 304
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 402479673 367 GWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVnatGSFNGALVFVGANAIAAIL 428
Cdd:cd17472  305 LPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLW---GLLGYSSVFLTILILALLW 363
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
19-216 6.64e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 48.36  E-value: 6.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  19 WFIVFMLFLVTSINYADRATLSITgdSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFF 98
Cdd:COG2211  230 FLLLLLAYLLFFLALALVAALLLY--YFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  99 TLLqgaiGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSE-------RGTASAFFNSAQYFAIVIFSPLMG 171
Cdd:COG2211  308 LLL----LFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAG 383
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 402479673 172 WLTHSFGWHS--------------VFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELA 216
Cdd:COG2211  384 LLLALFGYVAgaaqspsaltgirlLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELA 442
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
61-432 7.78e-06

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 47.91  E-value: 7.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  61 FSAFGWAYV---IGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQGAI-GFFSAGT-AIILLFALRFLVGLSEAPSFPGN 135
Cdd:cd17369   47 FATFGVGFLarpLGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLpTYAQIGIlAPILLVLLRLLQGLALGGEWGGA 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 136 GRVVASWFPSSERGTASAF----FNSAQYFAIVIFSPLMGWLTH----SFGWHSVFVVmgiAGILLAV-IWLK-TVYEPK 205
Cdd:cd17369  127 VLMAVEHAPPKRRGFYGSFpqlgAPVGLLLATGVFLLLSALLSDeaflSWGWRIPFLL---SAVLVAVgLYIRlRLEETP 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 206 KHPKVNEaelayieqggglismddskskQETESKWPYIKQLLTN-RMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMS 284
Cdd:cd17369  204 VFRRAKE---------------------AGQVVRAPLVEVLRRHwRALLLAIGLRLAENVLFYLFTTFALSYATQTLGVD 262
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 285 ---ILEAGFVASlpaLCGFAGGVLGGIVSDillkkgrslTFARKVPIIAGMLLSCSMIV-----CNYTDSAWLVVVIMSL 356
Cdd:cd17369  263 rstVLLAVLIAS---VVAAITIPLFGWLSD---------RVGRRPVYLAGALLAALFAFpffwlLDTGSTWLIVLAAVVV 330
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 357 AFFGKG--FGALGwAVVSDTSPKEC--AGLSGGlFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLL 432
Cdd:cd17369  331 LGVLHGmmYGPQA-AFLAELFPTRVryTGASLG-YQLGAILGGGFAPLIATALVAATGSWWPVALYLAALAVISLVAALF 408
PRK03893 PRK03893
putative sialic acid transporter; Provisional
46-199 1.09e-05

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 47.77  E-value: 1.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  46 VQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQG-AIGFFSagtaiilLFALRFLV 124
Cdd:PRK03893  46 VQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGfAPGYWT-------LFIARLVI 118
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 402479673 125 GLSEAPSFPGNGR-VVASWfPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVmGIAGILLAViWLK 199
Cdd:PRK03893 119 GMGMAGEYGSSATyVIESW-PKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFFI-GILPIIFAL-WLR 191
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
250-433 1.60e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 46.89  E-value: 1.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 250 RMLIGVYIAQYCITTLTYFFLTWFPvYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILlkkGRsltfaRKVPII 329
Cdd:COG2814   10 LALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF---GR-----RRVLLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 330 AGMLLSCSMIVCNYTDSAWLVVVIMSL-AFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNA 408
Cdd:COG2814   81 GLLLFALGSLLCALAPSLWLLLAARFLqGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
                        170       180
                 ....*....|....*....|....*
gi 402479673 409 TGSFNGALVFVGANAIAAILSYLLL 433
Cdd:COG2814  161 FGWRWVFLVNAVLALLALLLLLRLL 185
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
49-211 1.72e-05

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 46.83  E-value: 1.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  49 DLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFwsfFTLlqgaIGFFSAGT-AIILLFALRFLVGLS 127
Cdd:PRK11102  20 DFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLV---FAL----AAVACALAqTIDQLIYMRFLHGLA 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 128 EAPSFPGNGRVVASWFPSSErgtasafFNSAQYFAIVIF--SPLM-----GWLTHSFGWHSVFVVMGIAGILLAV-IWLK 199
Cdd:PRK11102  93 AAAASVVINALMRDMFPKEE-------FSRMMSFVTLVMtiAPLLapiigGWLLVWFSWHAIFWVLALAAILAAAlVFFF 165
                        170
                 ....*....|..
gi 402479673 200 TvyePKKHPKVN 211
Cdd:PRK11102 166 I---PETLPKER 174
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
49-434 3.18e-05

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 46.06  E-value: 3.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  49 DLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIalsIFFWSFFTLLqGAIGFFSAGTAIILLFAlRFLVGLSE 128
Cdd:cd17490   25 SLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLF---IIIGLLFTVL-ASLIMILFPSPWGLLIA-RFLSGIAA 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 129 AP--SFPgngRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYE-PK 205
Cdd:cd17490  100 ATwvSFT---VLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEErRE 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 206 KHPKVNEaelayieqggglismddskskqeteskWPYIKQLLTNRMLIGVY---IAQYCITTLTYFFLTwfPVYLVQArG 282
Cdd:cd17490  177 KKPVLTE---------------------------LKELLSVLKDKKLLFFSllaILQQMITFSTTFGFT--PLIAKQL-G 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 283 MSILEAGFVASLPALCGFAGGVLGGIVsdILLKKGrsltfARKVPIIAGMLLSCSMIVCNYTDSAWLVVVIMSLAFFGKG 362
Cdd:cd17490  227 ASSFQLGLLSIIYLLPNALASLLSGTL--FYKKLG-----ERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTG 299
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 402479673 363 --FGALGWAVVSDTsPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGsFNGALVFVGANAIAAILSYLLLV 434
Cdd:cd17490  300 ilFPLLMSLSIEGV-PAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFG-LQTGFFVIGVIALLAAILSLAYY 371
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
48-196 3.91e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 45.62  E-value: 3.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  48 HDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLqgaigFFSAGTaiILLFALRFLVGLS 127
Cdd:cd17478  223 VQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLL-----FLLTPG--IWSYILLVLAGFL 295
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 402479673 128 EAPSFPGNGRVVASWFPSSeRGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVI 196
Cdd:cd17478  296 LFASFPVTVVLAQELLPGN-VGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALL 363
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
54-433 4.59e-05

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 45.72  E-value: 4.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  54 SVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQgaiGFFSAGTAIILLFALRFLVGLSEAPSFP 133
Cdd:cd17357   48 DLLWSLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLM---FLSKSAKSPELLIFGRFLVGIACGLSTG 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 134 GNGRVVASWFPSSERGTASAFFNSAQYFAIVI-----FSPLMGWLTHsfgWHSVFVVMGIAGILLAVIWLKTVYEPK--- 205
Cdd:cd17357  125 FVPMYLQEISPSELRGALGSLTQIGVTLGILLgqvfgLPSVLGTETL---WPYLLFFPGIPALLQLAALPFFPESPKfll 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 206 -KHPKVNEAELA----YIEQGGGLISMDDSK--SKQETESKWPYIKQLLTN-----RMLIGVYIA---QYCITTLTYFFL 270
Cdd:cd17357  202 iSKGDEEEAEKSlkflRGIEDDVDQELEEIKkeSEQMGDQKQVSLMQLLRDpslrlPLLLVLVVSasqQFSGINAIFFYS 281
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 271 TWFpvylvqargmsILEAGFVASLPALCGFAGG---VLGGIVSDILLKK-GRS--LTFARKVPIIAGMLLSCSMIVCNYT 344
Cdd:cd17357  282 TFI-----------FENAGFSPQLAEWANLGIGivnVLSTIVGPFLIEKvGRRplLLISLSVCAVALLLMSVFLFLSEQN 350
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 345 DS-AWLVVV--IMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNgALVFVGA 421
Cdd:cd17357  351 SWmSYGCIVaiFLFIFFFAIGLGPIPWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSIGGGFV-FIIFAIP 429
                        410
                 ....*....|..
gi 402479673 422 NAIAAILSYLLL 433
Cdd:cd17357  430 CALFLLYLYRYL 441
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
57-364 5.40e-05

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 45.25  E-value: 5.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  57 MGYVFSAFGWAYVIGQLPGGWLLDRFGSKtiialsiffWSFFTllqgAIGFFSAGTAI-------ILLFALRFLVGLSEA 129
Cdd:cd17502   32 VSWVGTAYLLTSTAFQPIYGKLSDLFGRK---------WVLLI----AIVIFELGSLLcglapnmTMLIVGRAIQGIGGG 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 130 PSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVV-MGIAGILLAVIwlktvyepkkhp 208
Cdd:cd17502   99 GLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYInLPIGGLALALL------------ 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 209 kvneaelayieqggglismddskskqeteskwpyikqlltnRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILEA 288
Cdd:cd17502  167 -----------------------------------------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKS 205
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 402479673 289 GfVASLPALCGFaggVLGGIVSDILLKKGRSLtfaRKVPIIAGMLLSCS---MIVCNYTDSAWLVVVIMSLAFFGKGFG 364
Cdd:cd17502  206 G-VRLLPLIIGL---VIGSIISGALISKTGRY---KPLIVIGTILMSVGaglLTTLTLDTSKWLLIGYLILLGLGLGIG 277
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
46-432 6.12e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 44.88  E-value: 6.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  46 VQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQGaigfFSagTAIILLFALRFLVG 125
Cdd:cd17504   22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAA----FA--PNLPVLIAGRALQG 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 126 LSeAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAViwlktvyepk 205
Cdd:cd17504   96 IG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAA---------- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 206 khpkvneaelayieqgggLISMDDSKskqeteskwpyikqLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQAR---- 281
Cdd:cd17504  165 ------------------LVPLIDLR--------------LLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTptgf 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 282 GMSILEAGFVASLPALCGFAGGVLGGIVsdillkkgrSLTFARKVPIIAGMLLSC--SMIVCNYTDSAWLVVVIMSLAFF 359
Cdd:cd17504  213 GLGITEAGLLLLPGALVMLIAGPLAGRL---------IARVGPRRVLLIGLVISAvgLLLLALLHSSLWALVVALLLIGI 283
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 360 GKG--FGALGWAVVSDTSPKECA---GLSGGLFNTFGNIASI---------TTPIIIGYIVNATGSFNGALVFVGANAIA 425
Cdd:cd17504  284 GLGlaFASLPNIVVESVPPDRTGiatGMNTVLRTIGSAIGPAiagailttyTVSITSGGVPTEGAYVLAFLIGAALALAA 363

                 ....*..
gi 402479673 426 AILSYLL 432
Cdd:cd17504  364 LLLSLLI 370
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
50-374 1.11e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 44.52  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  50 LGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSK-----------TIIALSIFFWSFFTLLQGAIGFFSAGTAIILLF 118
Cdd:cd17332   30 LGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRwgrfrpwllwgAIPLALLFVLLFTTPDGSGTGKLIYALITYILL 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 119 ALRF-LVGLSeapsfpgngrvVASWFP-----SSERGTASAFF----NSAQYFAIVIFSPLMGWLTH---SFGWHSVFVV 185
Cdd:cd17332  110 DLLYtLVNIP-----------YTALIPeltddPEERTSLTSWRmffaTIGGLLVTVLPPPLVAYFGGgnaSRGYFLTALI 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 186 MGIAGILLAVIWLKTVYEPKKHPKVNEAELAYIEQggglismddskskqeteskwpyIKQLLTNRMLIGVYIAQYCITTL 265
Cdd:cd17332  179 IGIIGIILLLICFFGTRERVVPPEEEKSKLPLLKS----------------------LKALLKNRPFLILLLAYLLYFLA 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 266 TYFFLTWFPVYLVQARGmsileaGFVASLPALCGFAGGVLGGIVSDILLKKgrslTFARKVPIIAGML---LSCSMIVCN 342
Cdd:cd17332  237 FNIVNTVLVYYFKYVLG------GRAELVLLLLLILSGALLALLPWPPLKK----RFGKKKAFFIGLLlaiLGLLLLFFL 306
                        330       340       350
                 ....*....|....*....|....*....|...
gi 402479673 343 YTDSAWLVVVIMSLAFFGKGFG-ALGWAVVSDT 374
Cdd:cd17332  307 PPGNLVLILVLAVLAGIGYGGAnLLPWAMLADV 339
uhpT PRK09556
hexose-6-phosphate:phosphate antiporter;
18-391 1.54e-04

hexose-6-phosphate:phosphate antiporter;


Pssm-ID: 236564 [Multi-domain]  Cd Length: 467  Bit Score: 43.88  E-value: 1.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  18 RWFIVFM-LFLVTSINYAD----RATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSI 92
Cdd:PRK09556  22 MWFKPFMqSYLVVFIGYLTmyliRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLL 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  93 FFWSFFTLLQGAIgFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGW 172
Cdd:PRK09556 102 ILSAICMLGFGAS-LGSGSVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALW 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 173 LTHSFGWHSV---FVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYIEQggglISMDDSKSKQETESKWPYIKQ-LLT 248
Cdd:PRK09556 181 GANYFFDGHVigmFIFPSIIALIIGFIGLRYGSDSPEELGWGKAEEIFGEP----ISEEDKETESTDMTKWQIFVEyVLK 256
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 249 NRML-------IGVYIAQYCITtltyfflTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDiLLKKGRSLT 321
Cdd:PRK09556 257 NPVIwllcfanIFLYIVRIGID-------NWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSD-LANGRRALV 328
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 402479673 322 FARKVPIIAGMLLScsmivcnYTDSAWLVVVIMSLAFFGK-GFGA---LGWAVVSdTSPKECAGLSGGLFNTFG 391
Cdd:PRK09556 329 ACIALALIIFTLGV-------YQHATSEYMYLASLFALGFlVFGPqllIGVAAVG-FVPKKAIGVANGIKGTFA 394
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
67-196 1.61e-04

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 43.77  E-value: 1.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  67 AYVIGQLPGGWLLDRFGSKTIIALSIFFwsfFTLLQGAIGFFSAGTAIILLFALrflVGLSEAPSFPGNGRVVASWFPSS 146
Cdd:cd17313  293 AFLIFSLPIGKLGKKIGRKKVYLIGLVL---FAVGMALMALVHNVTVALVLFAL---GGIGWATININPYPLVSDYHSES 366
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 402479673 147 ER--GTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVI 196
Cdd:cd17313  367 GRgqGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVG 418
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
19-196 1.76e-04

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 43.75  E-value: 1.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  19 WFIVFMLFLVTSINYADRATLSitgDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLL-DRFGSKTIIALSIffwsf 97
Cdd:cd17490  197 LFFSLLAILQQMITFSTTFGFT---PLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFyKKLGERNTIIIGF----- 268
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  98 ftLLQGAIGFFSAGT-AIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHS 176
Cdd:cd17490  269 --LLLGAYCFLIPFApNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEA 346
                        170       180
                 ....*....|....*....|
gi 402479673 177 FGWHSVFVVMGIAGILLAVI 196
Cdd:cd17490  347 FGLQTGFFVIGVIALLAAIL 366
MFS_NIMT_CynX_like cd17339
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ...
265-428 2.15e-04

2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340897 [Multi-domain]  Cd Length: 374  Bit Score: 43.33  E-value: 2.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 265 LTYFFLTWFPVYLVQaRGMSILEAGFVASLPALCGFAGGVLGGIVSDiLLKKGRSLTFARKVPIIAGMLlscsMIVCNYT 344
Cdd:cd17339  211 LFYTLMAWLPTILID-AGLSAATAGWLLSLFQLVGIPASLLVPILAT-RLKNQRPIVVLLAVLFIIGVL----GLLFAPT 284
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 345 DSAWLVVVIMSLAFfGKGFG-ALGWAVVSDTSPKECAGLSGgLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANA 423
Cdd:cd17339  285 ALALLWAVLLGLGG-GAAFSlALTLISLRSSDPAEAAALSG-MAQSVGYLLAALGPLLFGVLHDLTGSWTAPLVLLLALT 362

                 ....*
gi 402479673 424 IAAIL 428
Cdd:cd17339  363 VLQLV 367
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
267-433 2.35e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 43.33  E-value: 2.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 267 YFFLTWFPVY--------LVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILlkkGrsltfARKVPIIAGMLLSCSM 338
Cdd:COG2223   13 AFFLAFGVWYlwsvlappLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRF---G-----PRRVLLIGLLLLGIGL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 339 IVCNYTDSAWLVVVIMSLAFFGKGFGALGW-AVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALV 417
Cdd:COG2223   85 LLLALAVSYWLLLLLGLLLGIGGGGSFAVGiALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLI 164
                        170
                 ....*....|....*.
gi 402479673 418 FVGANAIAAILSYLLL 433
Cdd:COG2223  165 LGILLLVVAVLAWLFL 180
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
45-198 2.35e-04

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 43.14  E-value: 2.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673   45 SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLlqGAIGFFSAGTaiilLFALRFLV 124
Cdd:TIGR00710  30 EIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSL--GLALSNNIET----LLVLRFVQ 103
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 402479673  125 GLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILL-AVIWL 198
Cdd:TIGR00710 104 AFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLsALIFF 178
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
61-433 2.73e-04

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 43.13  E-value: 2.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  61 FSAFGWAYV---IGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQG------AIGFfsAGTAIILLfaLRFLVGLSEAPS 131
Cdd:cd17368   43 FATFGVGFFmrpIGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIAlaptyaTIGI--AAPLLVLL--ARLLQGFAAGGE 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 132 FPGNGRVVASWFPSSERGTASAFFNSAQYFAIViFSPLMG-----WLTH----SFGWHSVFVVmgiaGILLAVI--WLKT 200
Cdd:cd17368  119 VGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIV-AGALVGyllslTLTAealaEWGWRIPFFI----GLLIIPLglWLRR 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 201 VYEPkkhpkvNEAELAyieqggglismddSKSKQETESkwpYIKQLLTNR--MLIGVYIAQYCiTTLTYFFLTWFPVYLV 278
Cdd:cd17368  194 SLEE------TEAFLE-------------RKARPTRRE---LFALLANNRriILLGMLLVAGS-TVTFYFTTVYTPTYAK 250
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 279 QARGMSILEAGFVASLPALCGFAGGVLGGIVSDillKKGRsltfaRKVPIIAgmllSCSMIVCNYTDSAWLV-------- 350
Cdd:cd17368  251 TVLGLSARDSFLVTLLAGVANFIWAPLGGALSD---RIGR-----RPVLLVI----TLAALVTLYPVFAWLTaapsfgrl 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 351 -VVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFG-NIASITTPIIIGYIVNATGSFNGALVFVGANAIAAIL 428
Cdd:cd17368  319 lLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAvAIFGGFAQFIVTWLIELTGSPLAPAWYLMGAALLGLL 398

                 ....*
gi 402479673 429 SYLLL 433
Cdd:cd17368  399 ATLML 403
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
49-196 5.52e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 41.79  E-value: 5.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  49 DLGLDSVAMGYVFSAFGWAYVIGQLP-GGWLLDRFGSKTIIALSIFFWSFFTLLQGAIGFFSagtaiiLLFALRFLVGLS 127
Cdd:cd17330  204 RFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVP------LLVLAAAILAFG 277
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 402479673 128 EAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVI 196
Cdd:cd17330  278 TGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFL 346
MFS_SLC49 cd17334
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ...
18-433 6.09e-04

Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340892 [Multi-domain]  Cd Length: 407  Bit Score: 42.00  E-value: 6.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  18 RWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSF 97
Cdd:cd17334    2 RWVVLLLFSLLSFSNAMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALNAL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  98 FTLLQgAIGFFSAGTAIILLFAlRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVI---FSPLMGWLT 174
Cdd:cd17334   82 GSVLK-CIPLGQQPKFALLVLG-QVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGCAIgflLPPVVVPPP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 175 HSFGWH---SVFVVMGIAGILLAVIWLKTVYEPKKHPKVneAELAYIEQGGGLISMDDSKSKQETESkwPYIKQLLTNRM 251
Cdd:cd17334  160 KGTKKEfgaVFYGEFGFACLLLALVLALFPPKPKYPPSA--ASARQQNSEHVILELQKSISELLRNE--PFVLLAVAFSI 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 252 LIGVYIAqycittltyffltwFPVYLVQArgmsILEAGFVASLPALCGFAGGVlGGIVSDILLkkGRSLTFARKVPIIAG 331
Cdd:cd17334  236 MMGVFAG--------------FSSVLAQI----LLPFGVSQTSAGWLGFFGIV-AGMVGGLLL--GLFVDRTRMFKLIGL 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 332 MLLSCSMIVCNYT----------DSAWLVVVIMS-LAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPI 400
Cdd:cd17334  295 IILALGTVVCTFFmllvdryglpYVTLAFYLLCGlLGFFQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLML 374
                        410       420       430
                 ....*....|....*....|....*....|...
gi 402479673 401 IIGYIVNATGSFNGALVFVGANAIAAILSYLLL 433
Cdd:cd17334  375 VFSELLGPTPTESKYLLWFILCTVGSCLGALFF 407
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
50-433 7.00e-04

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 41.82  E-value: 7.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  50 LGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSiffwsfftllqgaigfFSAGTAIILLFALR---FLVGL 126
Cdd:cd17331   30 LGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLS----------------FLSSALSYLLLAFAssvPMLFL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 127 SEAPS-----FPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTV 201
Cdd:cd17331   94 SRLPSvfmhaMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLI 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 202 YEPKKHPKVNEAElayiEQGGGLISMDDSKSKQETesKWPYIKQLLTNRMLIGVYIAQYCITtltyffltwFPVYLVQAR 281
Cdd:cd17331  174 PSNTKSKREKEAK----ESASPPSVFNLKEILRLL--RLPGVAFLLLVKLLSGLPIGMFQSM---------FSLVAMDFF 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 282 GMSILEAGFVASlpaLCGFAGGVLGGIVSDILLKKG--RSLTFARKVPIIAGMLLSCSMivcnyTDSAWLVVVIMSLAFF 359
Cdd:cd17331  239 GLTPEENGYLMS---YAGVLGMVVQGLLVGPLTKRFgeRSLLKLSVALLAIGYLLLAFV-----TTVWQLLVLLLPLVIG 310
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 402479673 360 GKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSfnGALVFVGANAIAAILSYLLL 433
Cdd:cd17331  311 GSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGF--PSFGLLGAAINGLLTVYLLL 382
MFS_SLC37A1_2 cd17344
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ...
57-334 7.88e-04

Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340902 [Multi-domain]  Cd Length: 400  Bit Score: 41.53  E-value: 7.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  57 MGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQGaIGFFSAGTAIILLFALRFLVGLSEAPSFPGNG 136
Cdd:cd17344   64 LGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFG-LGYYWNIHSLWYFVVVQILAGLFQSTGWPSVV 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 137 RVVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLThSFGWHSVFVVMGIAGILLAVIwlktVYepkkhpkvneaeLA 216
Cdd:cd17344  143 ACVGNWFGKGKRGLIMGIWNSHTSVGNILGSLIAGIFV-SSAWGLSFIVPGIIIAAMGVL----VF------------LF 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 217 YIEQGGGLIsmddskskqeteskwPYIKQLLTNRMLigvyiaqycittlTYFFLTWFPVYLVQARGMSILEAGFVASLPA 296
Cdd:cd17344  206 LVEHPPGVI---------------EFSLCLFFAKLV-------------SYTFLYWLPLYISNTAILSAKKAGDLSTLFD 257
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 402479673 297 LCGFAGGVLGGIVSDILlkKGRSLTFARKVPIIAGMLL 334
Cdd:cd17344  258 VGGIVGGILAGYISDYT--GGRATTCAAMLILAAPMLF 293
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
47-214 8.00e-04

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 41.52  E-value: 8.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  47 QHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQGAIGFFsagtaiILLFALRFLVGL 126
Cdd:cd06180   26 LAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGF------AALLALRFLAGA 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 127 SEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIfSPLMGWLTHSFGWHSV---FVVMGIAGILLAVIWLKTVYE 203
Cdd:cd06180  100 ASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIAL-SGLLVPAGLGGGLSWRagwLALALLSAVLLLLSFLLLRRG 178
                        170
                 ....*....|.
gi 402479673 204 PKKHPKVNEAE 214
Cdd:cd06180  179 PSAPTEASAAE 189
Sugar_tr pfam00083
Sugar (and other) transporter;
49-434 8.10e-04

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 41.49  E-value: 8.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673   49 DLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQGAIGffsAGTAIILLFALRFLVGLse 128
Cdd:pfam00083  40 SLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAK---GKWSVYQLIVGRVLVGI-- 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  129 apsFPGNGRVVASWF-----PSSERGTASAFFNSAQYFAIV---IFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLK- 199
Cdd:pfam00083 115 ---GVGGASVLAPMYiseiaPKKLRGALGSLYQLAITFGILlayIFGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFl 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  200 --TVYEPKKHPKVNEAElAYIEQGGGLISMDDS------KSKQETESKWPYIKQLLTN-----RMLIGVYIAqyCITTLT 266
Cdd:pfam00083 192 peSPRWLVEKGRLEEAR-EVLAKLRGVPDVDREldeikdSLEAGQEAEKASWKELFSTktrrqRLLIGVMLQ--IFQQLT 268
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  267 -YFFLTWFPVYLVQARGMSileAGFVASLPALCGFAGGVLGGI-VSDillKKGRS--LTFARKVPIIAGMLLSCSMIVCN 342
Cdd:pfam00083 269 gINAIFYYSTTIFENLGLS---DSFLVTIIVGVVNFVFTFIAIfLVD---RFGRRplLLLGAAGMAICFVILGIVALLGV 342
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  343 YTDSAWLVVVIMSL----AFFGKGFGALGWAVVSDTSPKE----CAGLSGGLFNTFGNIASITTPIIIGYIvNATGSFng 414
Cdd:pfam00083 343 SKSDWAGIVAIVFIalfiAFFAMGWGPVPWVIVSELFPLSvrskAMALATAANWLANFLIGFLFPIITDAI-GLGYTF-- 419
                         410       420
                  ....*....|....*....|
gi 402479673  415 aLVFVGANAIAAILSYLLLV 434
Cdd:pfam00083 420 -FIFAGLLVLFIIFVFFFVP 438
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
1-198 1.08e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 41.02  E-value: 1.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673   1 MKKDFASVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITgdsVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLD 80
Cdd:cd17473  182 SAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFL---LQERGGGSAALIGLALAIASLAGAIGALLFGRLKR 258
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  81 RFGSKTIIALSIFFWsfftllqgAIGFFSAGTA--IILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSA 158
Cdd:cd17473  259 RLGKRRLLAIGFALM--------ALGFLLLALAsgLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSA 330
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 402479673 159 QYFAIVIFSPLMGWLTHSFGWHS-VFVVMGIAGILLAVIWL 198
Cdd:cd17473  331 FFLGQFLSPLVLGPLVNLTGGLSgAFLILGVLALVLAIVLL 371
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
58-200 1.21e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 41.10  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  58 GYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQGAigffsAGTAIILLfALRFLVGLSEAPSFPGNGR 137
Cdd:cd17391  243 GLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAF-----VQTPWQLG-ILRFLLGLATGGLLPAINS 316
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 402479673 138 VVASWFPSSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGIAgILLAVIWLKT 200
Cdd:cd17391  317 LLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALL-VLLNAIWSFI 378
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
48-198 1.52e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 40.62  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  48 HDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLqgaigfFSAGTAIILLFALRFLVGLs 127
Cdd:cd17477   24 EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLL------LALTDSPWVWFLLRFVMGI- 96
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 402479673 128 eapSFPGNGRVVASWF----PSSERGTASAFFNSAQYFAIVIfSPLMGWLTHSFGWhsVFVVMGIAGILLAVIWL 198
Cdd:cd17477   97 ---GLAGLFVVSESWLnalaTNENRGRVLGLYSTVLGLGFAL-GPLLLALVGTAGA--LPFLIAAVLLLLALVPL 165
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
70-434 2.37e-03

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 39.97  E-value: 2.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  70 IGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQGAI-GFFSAGTA--IILLFAlRFLVGLSEAPSFPGNGRVVASWFPSS 146
Cdd:cd17367   55 IGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTpTYATIGIWapIILLLA-RLLQGLSVGGEYGTSATYLSEVAPPG 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 147 ERGTASAF----FNSAQYFAIVIFSPLMGWLT----HSFGWHSVFVVMGIAGilLAVIWLKTVYEPKKHpkvNEAELAYI 218
Cdd:cd17367  134 RRGFYSSFqyvtLIGGQLLALGVLLVLQHTLGedqmAAWGWRIPFLLGGVLA--VVVLWLRRGLEETES---FEAIAESN 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 219 EQGGGLIsmddskskqetESKWPYIKQLLtnrMLIGVYIAQyciTTLTYFFLTWFPVYLVQARGMS---ILEAGFVASLP 295
Cdd:cd17367  209 EASAGTL-----------RELRRHPRELL---LVVGLTAGG---TLAFYTWTTYLQKFLVNTAGFSkgdATWITTAALLV 271
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 296 ALcgfAGGVLGGIVSDILLKKGRSLTFArkvpiIAGMLLSCSMIV-CNYTDSAWLVVVIMSLAF-FGKGFGALGWAVVSD 373
Cdd:cd17367  272 FM---LLQPLGGRLSDRIGRRPLLLFFG-----IGGTLATVPLLSaLDHTDSPYTAFALVLVGLvFLSGYTSINAVVKAE 343
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 402479673 374 TSPKEC----AGLSGGLFNT-FGNIASittpiiigYIVNATGSFNGALVFVGANAIAAILSYLLLV 434
Cdd:cd17367  344 LFPTHVralgVGLPYALAVAiFGGTAP--------YVALWLKSIGHEWVFFWYVAGLIAISLVVYL 401
MFS_MFSD3 cd17485
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ...
49-196 4.73e-03

Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341038 [Multi-domain]  Cd Length: 386  Bit Score: 39.13  E-value: 4.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  49 DLGLDSVAMGYVFSAFGW-AYVIGQLPGGWLLDRFGSKTIIALSIFF----WSFFTLLQGAIGFFSAGTAIILLFALRFL 123
Cdd:cd17485  236 DRGFSLSQIGLLSGVGGSlVSIAGSLLGGYLLKRRGRRRLLLLGGLLrlllLGLYTLLALGGSGLNWVLLLASLALLHLV 315
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 402479673 124 VGLSEAPSFPGNGRVVASwfpsSERGTASAFFNSAQYFAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVI 196
Cdd:cd17485  316 GGMITTALFTLMMDCSQQ----AQAGTDYTLLATVEVLGKLLFGSLAGFLADHLGYAAAFLLFAILSALSVLL 384
MFS_SLC37A3 cd17342
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ...
57-359 5.79e-03

Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340900 [Multi-domain]  Cd Length: 399  Bit Score: 38.83  E-value: 5.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  57 MGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQGAI----GFFSAgtaiILLFALRFLVGLSEAPSF 132
Cdd:cd17342   65 LGVLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLtewlHFYNK----YLYCILWVLNGLLQSTGW 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 133 PGNGRVVASWFPSSERGTASAFFNSAqyfAIV--IFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLktvyepkkhpkv 210
Cdd:cd17342  141 PCVVAIMGNWFGKSSRGFVLGLWSAC---ASVgnIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVF------------ 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 211 neaeLAYIEQGGGLIsmddskskqeteskwPYikqlltnrmligvYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGF 290
Cdd:cd17342  206 ----FGLLSSPPGVI---------------PY-------------SLAYACLKLVNYSFFFWLPFYLSNNFHWKESEADQ 253
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 402479673 291 VASLPALCGFAGGVLGGIVSDILLKKGrsltfarkvPIIAGMLLSC--SMIVCNYTDSAWLV-VVIMSLAFF 359
Cdd:cd17342  254 LSIWYDVGGIIGGIVAGYISDRMGSRS---------PVVVVMLLLAipSLFVYSHSPSDKVLnAFVMTITGF 316
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
44-216 6.13e-03

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 38.72  E-value: 6.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673  44 DSVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKT--IIALSIFfwsfftllqgAIGFFSAG--TAIILLFA 119
Cdd:PRK11043  30 KAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPvlLAGLSLF----------ALGSLGMLwvESAAQLLV 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402479673 120 LRFL--VGL-SEAPSFPGngrVVASWFPSSErgtasaffnSAQYFA----IVIFS----PLMG-WLTHSFGWHSVFVVMG 187
Cdd:PRK11043 100 LRFVqaVGVcSAAVIWQA---LVIDRYPAQK---------ANRVFAtimpLVALSpalaPLLGaWLLNHFGWQAIFATLF 167
                        170       180
                 ....*....|....*....|....*....
gi 402479673 188 IAGILLAviwLKTVYEPKKHPKVNEAELA 216
Cdd:PRK11043 168 AITLLLI---LPTLRLKPSKKARKQSQDA 193
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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