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Conserved domains on  [gi|410027338|gb|AFV52751|]
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DNA gyrase subunit A, partial [Bacillus subtilis]

Protein Classification

DNA gyrase subunit A family protein( domain architecture ID 1000081)

DNA gyrase subunit A (GyrA) forms a 2:2 heterotetrameric complex with GyrB to form gyrase, a type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state; may be partial

CATH:  1.10.268.10|3.90.199.10
PubMed:  11395412|9519293|17397985

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05560 super family cl35335
DNA gyrase subunit A; Validated
 1-297 0e+00

DNA gyrase subunit A; Validated


The actual alignment was detected with superfamily member PRK05560:

Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 692.93  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338   1 VRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDS 80
Cdd:PRK05560  34 VRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDP 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338  81 AAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLA 160
Cdd:PRK05560 114 AAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACLA 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338 161 VSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTsSGKERIIVTELPYQVNKAKLIEKI 240
Cdd:PRK05560 194 LIDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKAEIEEI-KGREAIIVTEIPYQVNKARLIEKI 272

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 410027338 241 ADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL 297
Cdd:PRK05560 273 AELVKEKKIEGISDLRDESDRDGMRIVIELKRDAVPEVVLNNLYKHTQLQTSFGINM 329
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 1-297 0e+00

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 692.93  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338   1 VRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDS 80
Cdd:PRK05560  34 VRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDP 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338  81 AAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLA 160
Cdd:PRK05560 114 AAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACLA 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338 161 VSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTsSGKERIIVTELPYQVNKAKLIEKI 240
Cdd:PRK05560 194 LIDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKAEIEEI-KGREAIIVTEIPYQVNKARLIEKI 272

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 410027338 241 ADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL 297
Cdd:PRK05560 273 AELVKEKKIEGISDLRDESDRDGMRIVIELKRDAVPEVVLNNLYKHTQLQTSFGINM 329
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-297 0e+00

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 679.84  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338   1 VRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDS 80
Cdd:COG0188   39 VRDGLKPVHRRILYAMHELGLTPDKPYKKSARVVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDP 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338  81 AAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLA 160
Cdd:COG0188  119 AAAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACIA 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338 161 VSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEKI 240
Cdd:COG0188  199 LIDNPDATIEELMEYIPGPDFPTGGIIVGREGIREAYETGRGSIRVRAKAEIEELKRGREQIVVTEIPYQVNKARLIEKI 278

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 410027338 241 ADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL 297
Cdd:COG0188  279 AELVKEKKIEGISDVRDESDRDGMRIVIELKRDANPEVVLNQLYKHTQLQTSFGINM 335
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 1-297 0e+00

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 607.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338    1 VRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDS 80
Cdd:TIGR01063  30 VRDGLKPVHRRILYAMYELGLTPDKPYKKSARIVGDVMGKYHPHGDSAIYDTLVRMAQDFSLRYPLVDGQGNFGSIDGDP 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338   81 AAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLA 160
Cdd:TIGR01063 110 PAAMRYTEARLTKIAEELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLLVNGSSGIAVGMATNIPPHNLGEIIDALLA 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338  161 VSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEKI 240
Cdd:TIGR01063 190 YIDNPDISIQELLEVIKGPDFPTGGIILGRSGIRSAYETGRGSIVIRARAEIEEDSKGREAIIVTEIPYQVNKARLIEKI 269

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 410027338  241 ADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL 297
Cdd:TIGR01063 270 AELVREKKIEGISDIRDESDREGIRIVIELKRDAVAEVVLNNLYKQTQLQVSFGINM 326
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 1-297 0e+00

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 535.99  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338   1 VRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDS 80
Cdd:cd00187    8 VRDGLKPVQRRILYAMFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNFGSRDGDD 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338  81 AAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLA 160
Cdd:cd00187   88 AAAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLREVIDALRA 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338 161 VSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEqTSSGKERIIVTELPYQVNKAKLIEKI 240
Cdd:cd00187  168 LIDNPEASIDELMEIIKGPDFPTGGIIEGRAGIREAYETGRGRYIIRGKYEIE-DDEGRNTIEITELPYQVNKAKLKEKI 246

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 410027338 241 ADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL 297
Cdd:cd00187  247 AELVKDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGINM 303
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
1-297 1.09e-170

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 479.74  E-value: 1.09e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338    1 VRDGLKPVHRRILYAMNDLgMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV-DGD 79
Cdd:pfam00521   6 VRDGLKPVQRRILYAMFEL-LNLDKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGSRiDGD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338   80 SAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVL 159
Cdd:pfam00521  85 KDAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREIIDALI 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338  160 AVSENPDITIpeLMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQtssgKERIIVTELPYQVNKAKLIEK 239
Cdd:pfam00521 165 ALLDGPEATL--LMKYIMGPDFPTGGGIIGKGGIKEAYKTGRGKITVRAKVEIED----RKTIVITELPYGVWTSDLIEK 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 410027338  240 IADLVRDKKIEGITDLRDESDRtGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL 297
Cdd:pfam00521 239 IEELVKNGKIKGISDIRDESDR-GVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNN 295
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 1-297 2.07e-169

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 476.67  E-value: 2.07e-169
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338     1 VRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV-DGD 79
Cdd:smart00434  27 VRDGLKPVQRRILYAMFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIVRMAQDFSNNYPLLDGQGNFGSRlDGD 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338    80 SAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVL 159
Cdd:smart00434 107 DAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVNGSSGIAVGMATNIPPHNLREVIDAVR 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338   160 AVSENPDITIPELMEVIPGPDFPTAGQILGRSgirkayesgrgSITIRAKAEIEqtssGKERIIVTELPYQVNKAKLIEK 239
Cdd:smart00434 187 RLIDNPDASIDELMMIPWGPDFPTGGEIVGPG-----------KYVVRGKIEIE----DDNTIVITELPYQVNTADLIEK 251

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 410027338   240 IADLVRDKKIEGITDLRDES-DRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL 297
Cdd:smart00434 252 IAELVKDKKIEGIIDVRDEShDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTTFSINM 310
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 1-297 0e+00

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 692.93  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338   1 VRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDS 80
Cdd:PRK05560  34 VRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDP 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338  81 AAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLA 160
Cdd:PRK05560 114 AAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACLA 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338 161 VSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTsSGKERIIVTELPYQVNKAKLIEKI 240
Cdd:PRK05560 194 LIDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKAEIEEI-KGREAIIVTEIPYQVNKARLIEKI 272

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 410027338 241 ADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL 297
Cdd:PRK05560 273 AELVKEKKIEGISDLRDESDRDGMRIVIELKRDAVPEVVLNNLYKHTQLQTSFGINM 329
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-297 0e+00

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 679.84  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338   1 VRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDS 80
Cdd:COG0188   39 VRDGLKPVHRRILYAMHELGLTPDKPYKKSARVVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDP 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338  81 AAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLA 160
Cdd:COG0188  119 AAAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACIA 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338 161 VSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEKI 240
Cdd:COG0188  199 LIDNPDATIEELMEYIPGPDFPTGGIIVGREGIREAYETGRGSIRVRAKAEIEELKRGREQIVVTEIPYQVNKARLIEKI 278

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 410027338 241 ADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL 297
Cdd:COG0188  279 AELVKEKKIEGISDVRDESDRDGMRIVIELKRDANPEVVLNQLYKHTQLQTSFGINM 335
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 1-297 0e+00

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 607.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338    1 VRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDS 80
Cdd:TIGR01063  30 VRDGLKPVHRRILYAMYELGLTPDKPYKKSARIVGDVMGKYHPHGDSAIYDTLVRMAQDFSLRYPLVDGQGNFGSIDGDP 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338   81 AAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLA 160
Cdd:TIGR01063 110 PAAMRYTEARLTKIAEELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLLVNGSSGIAVGMATNIPPHNLGEIIDALLA 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338  161 VSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEKI 240
Cdd:TIGR01063 190 YIDNPDISIQELLEVIKGPDFPTGGIILGRSGIRSAYETGRGSIVIRARAEIEEDSKGREAIIVTEIPYQVNKARLIEKI 269

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 410027338  241 ADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL 297
Cdd:TIGR01063 270 AELVREKKIEGISDIRDESDREGIRIVIELKRDAVAEVVLNNLYKQTQLQVSFGINM 326
PRK05561 PRK05561
DNA topoisomerase 4 subunit A;
1-297 0e+00

DNA topoisomerase 4 subunit A;


Pssm-ID: 235503 [Multi-domain]  Cd Length: 742  Bit Score: 566.66  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338   1 VRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDS 80
Cdd:PRK05561  39 VRDGLKPVQRRILYAMSELGLTPDAKFKKSARVVGDVLGKYHPHGDSSIYDAMVRMAQDFSYRYPLVDGQGNFGSIDGDP 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338  81 AAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLA 160
Cdd:PRK05561 119 AAAMRYTEARLSPIAELLLEEIDEGTVDFVPNFDGTLKEPTVLPARFPNLLLNGATGIAVGMATDIPPHNLREVIDAAIH 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338 161 VSENPDITIPELMEVIPGPDFPTAGQIL-GRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEK 239
Cdd:PRK05561 199 LIDNPDATLEELMEFVPGPDFPTGGEIItGRDGIRKAYETGRGSIRVRARWEIEDLAGGRWQIVITELPYQVSKAKLIEQ 278

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338 240 IADLVRDKKIEGITDLRDESDRTG-MRIVIEIR-RDANANVILNNLYKQTALQTSFGINL 297
Cdd:PRK05561 279 IAELMNAKKLPGIADVRDESDRENpVRIVIEPKsNRVDPEALMNHLFATTDLESSYRVNM 338
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 1-297 0e+00

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 535.99  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338   1 VRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDS 80
Cdd:cd00187    8 VRDGLKPVQRRILYAMFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNFGSRDGDD 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338  81 AAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLA 160
Cdd:cd00187   88 AAAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLREVIDALRA 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338 161 VSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEqTSSGKERIIVTELPYQVNKAKLIEKI 240
Cdd:cd00187  168 LIDNPEASIDELMEIIKGPDFPTGGIIEGRAGIREAYETGRGRYIIRGKYEIE-DDEGRNTIEITELPYQVNKAKLKEKI 246

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 410027338 241 ADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL 297
Cdd:cd00187  247 AELVKDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGINM 303
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
1-297 1.09e-170

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 479.74  E-value: 1.09e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338    1 VRDGLKPVHRRILYAMNDLgMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV-DGD 79
Cdd:pfam00521   6 VRDGLKPVQRRILYAMFEL-LNLDKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGSRiDGD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338   80 SAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVL 159
Cdd:pfam00521  85 KDAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREIIDALI 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338  160 AVSENPDITIpeLMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQtssgKERIIVTELPYQVNKAKLIEK 239
Cdd:pfam00521 165 ALLDGPEATL--LMKYIMGPDFPTGGGIIGKGGIKEAYKTGRGKITVRAKVEIED----RKTIVITELPYGVWTSDLIEK 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 410027338  240 IADLVRDKKIEGITDLRDESDRtGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL 297
Cdd:pfam00521 239 IEELVKNGKIKGISDIRDESDR-GVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNN 295
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 1-297 2.07e-169

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 476.67  E-value: 2.07e-169
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338     1 VRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV-DGD 79
Cdd:smart00434  27 VRDGLKPVQRRILYAMFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIVRMAQDFSNNYPLLDGQGNFGSRlDGD 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338    80 SAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVL 159
Cdd:smart00434 107 DAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVNGSSGIAVGMATNIPPHNLREVIDAVR 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338   160 AVSENPDITIPELMEVIPGPDFPTAGQILGRSgirkayesgrgSITIRAKAEIEqtssGKERIIVTELPYQVNKAKLIEK 239
Cdd:smart00434 187 RLIDNPDASIDELMMIPWGPDFPTGGEIVGPG-----------KYVVRGKIEIE----DDNTIVITELPYQVNTADLIEK 251

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 410027338   240 IADLVRDKKIEGITDLRDES-DRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL 297
Cdd:smart00434 252 IAELVKDKKIEGIIDVRDEShDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTTFSINM 310
PRK13979 PRK13979
DNA topoisomerase IV subunit A; Provisional
 1-297 4.64e-146

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 237576 [Multi-domain]  Cd Length: 957  Bit Score: 434.15  E-value: 4.64e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338   1 VRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDS 80
Cdd:PRK13979  42 VRDGLKPVHRRILYGAYMLKAFPDKPYYKSARIVGDILGKYHPHGDSSVYDAMVILAQDFTTRMPLIDGHGNWGSIDGDS 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338  81 AAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLA 160
Cdd:PRK13979 122 AAAMRYTEARLTPIAMEMLRDIDKDVVNMVDNYSDSEKEPEVLPARYPNLLVNGAFGIAVGLATNIPPHNLKEVIDGTLA 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338 161 VSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEKI 240
Cdd:PRK13979 202 YIDNNEITTKELMNYIKGPDLPTGGILIGKKSLLSAYETGEGKVTLRAKTKIEKLENGRLGIVITEFPYRRNKAKLLQTI 281

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 410027338 241 ADLVRDKK----IEGITDLRDESDRTGMRIVIEIRRDAN---ANVILNNLYKQTALQTSFGINL 297
Cdd:PRK13979 282 SEMTADKKhskaLENISDIRDESDRNGIRAVIEFKKSADedvAEKVLKYLYKKTDLQCNISFNM 345
parC_Gpos TIGR01061
DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II ...
 1-297 2.03e-141

DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273422 [Multi-domain]  Cd Length: 738  Bit Score: 415.74  E-value: 2.03e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338    1 VRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDS 80
Cdd:TIGR01061  30 IRDGLKPVQRRILYAMFQDGNTFDKPYKKSARTVGEIMGKYHPHGDSSIYDAMVRMSQDWKNNWTLVEMHGNNGSIDGDN 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338   81 AAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLA 160
Cdd:TIGR01061 110 AAAMRYTEARLSLIASELLKDIDKKTVSFIPNFDDSEKEPTVLPALFPNLLINGATGIAAGYATNIPPHNLNEVIDALIY 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338  161 VSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEKI 240
Cdd:TIGR01061 190 RIDHPNCSVDKLMEIVKGPDFPTGGIIQGEDGISKAYETGKGKFIIRAKIEIEVNKNGLNQIVITEIPYETNKANIVKKI 269

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 410027338  241 ADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL 297
Cdd:TIGR01061 270 EEIIFDNKVAGIEEVRDESDRNGIRIIIELKKDANAEKILNFLFKHTDLQINYNFNM 326
parC_Gneg TIGR01062
DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II ...
 1-297 1.25e-127

DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 130134 [Multi-domain]  Cd Length: 735  Bit Score: 380.41  E-value: 1.25e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338    1 VRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDG-D 79
Cdd:TIGR01062  30 IGDGLKPVQRRIVYAMSELGLNANAKYKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDpK 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338   80 SAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVL 159
Cdd:TIGR01062 110 SFAAMRYTESRLSKISELLLEELGQGTVDFRPNFDGTLLEPVILPARLPNILLNGTTGIAVGMATDIPPHNLHELADAAL 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338  160 AVSENPDITIPELMEVIPGPDFPTAGQILG-RSGIRKAYESGRGSITIRAKAEIEQTSsgkerIIVTELPYQVNKAKLIE 238
Cdd:TIGR01062 190 YLIDNPKAGLDDILNIVQGPDFPTEAEIIDkAEEIRKIYETGRGSFRMRARWKKEDGQ-----IVISALPHQISKSKVIE 264

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 410027338  239 KIADLVRDKKIEGITDLRDESDRTG-MRIVIEIR-RDANANVILNNLYKQTALQTSFGINL 297
Cdd:TIGR01062 265 QIAIQMKDKKLPMISDIRDESDHENpIRVVIVPRsNRVDPDIVMEHLFATTDLEKSYRLNM 325
PRK09631 PRK09631
DNA topoisomerase IV subunit A; Provisional
 1-297 4.24e-57

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 236598 [Multi-domain]  Cd Length: 635  Bit Score: 193.77  E-value: 4.24e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338   1 VRDGLKPVHRRILYAMNDLgmtSDKPYKKSARIVGEVIgKYHPHGDSAVYESMVRMA-QDFnyrymLVDGHGNFGSV-DG 78
Cdd:PRK09631  28 VIDGLKPVQRRILHSLFEM---HDGKFHKVANVVGNTM-KYHPHGDASIYEALVNLAnKDL-----FIDKQGNFGNLfTG 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338  79 DSAAAMRYTEARMSKISMEIL--RDITkdtiDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIID 156
Cdd:PRK09631  99 DPASAARYIECRLTPLAKEVLynKEIT----EYEPSYDGRNNEPLCLPAKIPVILIQGAEGIAVGMATKILPHNFNEILQ 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338 157 GVLAVSENPDITIPelmevipgPDFPTAGqILGRSGirkaYESGRGSITIRAKAEIeqtsSGKERIIVTELPYQVNKAKL 236
Cdd:PRK09631 175 AVKSELLGESFALY--------PDFPTGG-IVDVSE----YADGNGKVLVRAKIET----KDEKTIVIREIPFGTTTESL 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 410027338 237 IEKIADLVRDKKIEgITDLrdeSDRTGMRIVIEIR--RDANANVILNNLYKQTALQTSFGINL 297
Cdd:PRK09631 238 IASIEKAARKGKIK-ISSI---NDYTAENVEIEIKlpRGVYASEVIEALYAYTDCEVSISVNL 296
PRK12758 PRK12758
DNA gyrase/topoisomerase IV subunit A;
1-240 4.75e-52

DNA gyrase/topoisomerase IV subunit A;


Pssm-ID: 237192 [Multi-domain]  Cd Length: 869  Bit Score: 182.90  E-value: 4.75e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338   1 VRDGLKPVHRRILYAMNDLgmtSDKPYKKSARIVGEVIgKYHPHGDSAVYESMVRMAQdfnyRYMLVDGHGNFGSV-DGD 79
Cdd:PRK12758  47 IEDGLKPVQRRILHSMKEM---DDGRYNKVANVVGHTM-QYHPHGDASIGDALVQLGQ----KDLLIDTQGNWGNIlTGD 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338  80 SAAAMRYTEARMSKISMEILrdITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVL 159
Cdd:PRK12758 119 GAAAPRYIEARLSKFALEVV--FNPKTTEWQLSYDGRKKEPVTLPVKFPLLLAQGAEGIAVGLSTKILPHNFNELIDASI 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338 160 AVSENPDITIPelmevipgPDFPTAGqILGRSgirkAYESGR--GSITIRAKaeIEQTSsgKERIIVTELPYQVNKAKLI 237
Cdd:PRK12758 197 AYLKGKEFKLY--------PDFPTGG-IIDVS----NYNDGErgGRVRVRAK--IEKLD--KKTLVITEIPYGTTTSSLI 259


                 ...
gi 410027338 238 EKI 240
Cdd:PRK12758 260 DSI 262
PRK09630 PRK09630
DNA topoisomerase IV subunit A; Provisional
 1-290 3.61e-43

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 170022  Cd Length: 479  Bit Score: 153.90  E-value: 3.61e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338   1 VRDGLKPVHRRILYAmndLGMTSDKPYKKSARIVGEVIGkYHPHGDSAVYESMVRMAqdfNYRYmLVDGHGNFGS-VDGD 79
Cdd:PRK09630  28 ILDGLKPVQRRLLWT---LFRMDDGKMHKVANIAGRTMA-LHPHGDAPIVEALVVLA---NKGY-LIDTQGNFGNpLTGD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338  80 SAAAMRYTEARMSKISMEILrdITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVL 159
Cdd:PRK09630 100 PHAAARYIEARLSPLAKEVL--FNTDLMTFHDSYDGREKEPDILPAKLPLLLLHGVDGIAVGMTTKIFPHNFCELLEAQI 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338 160 AVSENPDITIPelmevipgPDFPTAGQILGRSgirkaYESGRGSITIRAKAEIEQTSSgkerIIVTELPYQVNKAKLIEK 239
Cdd:PRK09630 178 AILNDQPFTLL--------PDFPSGGTMDASE-----YQDGLGSITLRASIDIINDKT----LLIKEICPSTTTETLIRS 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 410027338 240 IADLVRDK--KIEGITDLRDESDrtgmRIVIEIRRDANANVILNNLYKQTALQ 290
Cdd:PRK09630 241 IENAAKRGiiKIDSIQDFSTDLP----HIEIKLPKGIYAKDLLRPLFTHTECQ 289
52 PHA02592
DNA topisomerase II medium subunit; Provisional
 3-278 6.07e-36

DNA topisomerase II medium subunit; Provisional


Pssm-ID: 222896 [Multi-domain]  Cd Length: 439  Bit Score: 133.64  E-value: 6.07e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338   3 DGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEV--IGkYHpHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDS 80
Cdd:PHA02592  34 DGLKPVQRFVIHRALEYAKGNKEKFDKVAAIAGGVadLG-YH-HGETSAQDAGALMANTWNNNIPLLDGQGNFGSRLVQK 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338  81 AAAMRYTEARMSkismEILRDITKDtIDYQDNYDGSERepvvMPSRF-----PNLLVNGAAGIAVGMATNIPPHQLGEII 155
Cdd:PHA02592 112 AAAARYIFARVH----DNFRKIYKD-EDLAPVHEDPEH----IPPAFylpiiPMVLLNGVSGIATGYATNILPHSPKSVI 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338 156 DGVLAVSENPDITIPElmevipgPDFPtagqilGRSGirKAYESGRGSITIRAKAEIeqtsSGKERIIVTELPYQVNKAK 235
Cdd:PHA02592 183 KAVLAALNGKDITEPK-------VQFP------EFKG--EVVEIEPGSYEIRGTYEL----NGKTKLHITEIPVKYDRET 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 410027338 236 LIEKIADLVRDKKIEGITDLRDEsdrtGMRIVIEIRRDANANV 278
Cdd:PHA02592 244 YVAVLDPLEEKGKIVSYDDCTED----GFRFKVTLKREENEEA 282
PLN03128 PLN03128
DNA topoisomerase 2; Provisional
 3-292 3.98e-21

DNA topoisomerase 2; Provisional


Pssm-ID: 215593 [Multi-domain]  Cd Length: 1135  Bit Score: 93.62  E-value: 3.98e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338    3 DGLKPVHRRILYAMNDLGMTSDKpykKSARIVGEVI--GKYHpHGDSAVYESMVRMAQDF---NYRYMLVDgHGNFGS-- 75
Cdd:PLN03128  680 DGLKPSQRKVLFACFKRNLKSEI---KVAQLSGYVAehSAYH-HGEASLASTIIGMAQDFvgsNNINLLTP-SGQFGTrl 754

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338   76 VDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNyDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEII 155
Cdd:PLN03128  755 QGGKDAASARYIFTRLSPITRALFPKDDDVLLNYLNE-DGQSIEPEWYCPIIPMVLVNGSEGIGTGWSTFIPNYNPRDII 833

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338  156 DGVLAVSENPDitiPELMEvipgpdfPTAGQILGRsgIRKAYESGRGSITIRAKAEIEQTSSgkerIIVTELPYQV---N 232
Cdd:PLN03128  834 ANIRRLLRGEE---LEPMH-------PWYRGFKGT--ITEVSTSRSGSYTVTGIIEQIGDTT----IRITELPVRKwtqD 897

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 410027338  233 KAKLIEKIADLVRDKKIEgITDLRDESDRTGMRIVIEIRRDANANVILNNLYK----QTALQTS 292
Cdd:PLN03128  898 YKEFLEALLTGTKKKEPE-IKDFKENHTDTTVHFTVTLSEEKMARALAEGLEKkfklSTTISTS 960
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 3-296 1.49e-18

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 85.87  E-value: 1.49e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338    3 DGLKPVHRRILYAM------NDLgmtsdkpykKSARIVGEVIGK--YHpHGDSAVYESMVRMAQDF----NYRYMLVDGH 70
Cdd:PTZ00108  687 DGLKPGQRKILFACfkrnlkNEI---------KVAQLSGYVSEHsaYH-HGEQSLQQTIVGMAQNFvgsnNINLLYPCGQ 756

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338   71 gnFGS--VDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNyDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPP 148
Cdd:PTZ00108  757 --FGSrlQGGKDHAAARYIFTKLSKITRYIFPEEDDPILDYLED-DGQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPN 833

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338  149 HQLGEIIDGVLAVSENpditiPELMEVIPgpdfptagqilgrsgirkAYESGRGSITIRAKAEIEqtSSGK------ERI 222
Cdd:PTZ00108  834 YNPLDIIDNLRRRLNG-----EEVRPLVP------------------WYRGFKGTIERNPKGKFI--SKGIyekvpdGTV 888

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 410027338  223 IVTELPYQV---NKAKLIEKIAdlvrDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGIN 296
Cdd:PTZ00108  889 EITELPIGKwteDYKEFLESET----LKEKDVIVDYRDYSTANTVHFTVKLNDGVLEQWEEEGIEKVFKLKSTISTT 961
PLN03237 PLN03237
DNA topoisomerase 2; Provisional
 3-268 2.06e-13

DNA topoisomerase 2; Provisional


Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 70.66  E-value: 2.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338    3 DGLKPVHRRILYAMNDLGMTSDKpykKSARIVGEV--IGKYHpHGDSAVYESMVRMAQDF---NYRYMLVDGhGNFG--S 75
Cdd:PLN03237  705 DGLKPGQRKILFCSFKRNFVKEA---KVAQLSGYVseHSAYH-HGEQSLASTIIGMAQDFvgsNNINLLLPN-GQFGtrL 779

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338   76 VDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNyDGSEREPV-VMPSrFPNLLVNGAAGIAVGMATNIPPHQLGEI 154
Cdd:PLN03237  780 QGGKDHASARYIFTRLSPITRFLFPKDDDILLDYLNE-DGQSIEPTwYMPI-IPTVLVNGAEGIGTGWSTFIPNYNPRDI 857

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027338  155 IDGVLAVSENpditipELMEvipgPDFPTagqilgrsgirkaYESGRGSI--TIRAKAEIEQTSSGK------ERIIVTE 226
Cdd:PLN03237  858 VANIRRLLNG------ESME----PMHPW-------------YRGFKGTIekTASKEGGCTYTITGLyeevdeTTLRITE 914

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 410027338  227 LP---YQVNKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRIVI 268
Cdd:PLN03237  915 LPirrWTDDYKEFLESLKTDNNKNKDPFIKDVKAYNDDTTVHFEV 959
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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