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Conserved domains on  [gi|410027362|gb|AFV52763|]
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DNA gyrase subunit A, partial [Bacillus subtilis]

Protein Classification

DNA gyrase subunit A family protein( domain architecture ID 1000081)

DNA gyrase subunit A (GyrA) forms a 2:2 heterotetrameric complex with GyrB to form gyrase, a type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state; may be partial

CATH:  1.10.268.10|3.90.199.10
PubMed:  11395412|9519293|17397985

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05560 super family cl35335
DNA gyrase subunit A; Validated
 1-300 0e+00

DNA gyrase subunit A; Validated


The actual alignment was detected with superfamily member PRK05560:

Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 704.87  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362   1 ALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV 80
Cdd:PRK05560  30 ALPDVRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSI 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  81 DGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIID 160
Cdd:PRK05560 110 DGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVID 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362 161 GVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTsSGKERIIVTELPYQVNKAKL 240
Cdd:PRK05560 190 ACLALIDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKAEIEEI-KGREAIIVTEIPYQVNKARL 268

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362 241 IEKIADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGIN 300
Cdd:PRK05560 269 IEKIAELVKEKKIEGISDLRDESDRDGMRIVIELKRDAVPEVVLNNLYKHTQLQTSFGIN 328
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 1-300 0e+00

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 704.87  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362   1 ALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV 80
Cdd:PRK05560  30 ALPDVRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSI 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  81 DGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIID 160
Cdd:PRK05560 110 DGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVID 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362 161 GVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTsSGKERIIVTELPYQVNKAKL 240
Cdd:PRK05560 190 ACLALIDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKAEIEEI-KGREAIIVTEIPYQVNKARL 268

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362 241 IEKIADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGIN 300
Cdd:PRK05560 269 IEKIAELVKEKKIEGISDLRDESDRDGMRIVIELKRDAVPEVVLNNLYKHTQLQTSFGIN 328
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-300 0e+00

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 691.40  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362   1 ALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV 80
Cdd:COG0188   35 ALPDVRDGLKPVHRRILYAMHELGLTPDKPYKKSARVVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSI 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  81 DGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIID 160
Cdd:COG0188  115 DGDPAAAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVID 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362 161 GVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKL 240
Cdd:COG0188  195 ACIALIDNPDATIEELMEYIPGPDFPTGGIIVGREGIREAYETGRGSIRVRAKAEIEELKRGREQIVVTEIPYQVNKARL 274

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362 241 IEKIADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGIN 300
Cdd:COG0188  275 IEKIAELVKEKKIEGISDVRDESDRDGMRIVIELKRDANPEVVLNQLYKHTQLQTSFGIN 334
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 1-300 0e+00

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 617.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362    1 ALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV 80
Cdd:TIGR01063  26 ALPDVRDGLKPVHRRILYAMYELGLTPDKPYKKSARIVGDVMGKYHPHGDSAIYDTLVRMAQDFSLRYPLVDGQGNFGSI 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362   81 DGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIID 160
Cdd:TIGR01063 106 DGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLLVNGSSGIAVGMATNIPPHNLGEIID 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  161 GVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKL 240
Cdd:TIGR01063 186 ALLAYIDNPDISIQELLEVIKGPDFPTGGIILGRSGIRSAYETGRGSIVIRARAEIEEDSKGREAIIVTEIPYQVNKARL 265

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  241 IEKIADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGIN 300
Cdd:TIGR01063 266 IEKIAELVREKKIEGISDIRDESDREGIRIVIELKRDAVAEVVLNNLYKQTQLQVSFGIN 325
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 1-300 0e+00

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 545.62  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362   1 ALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV 80
Cdd:cd00187    4 ALPDVRDGLKPVQRRILYAMFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNFGSR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  81 DGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIID 160
Cdd:cd00187   84 DGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLREVID 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362 161 GVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEqTSSGKERIIVTELPYQVNKAKL 240
Cdd:cd00187  164 ALRALIDNPEASIDELMEIIKGPDFPTGGIIEGRAGIREAYETGRGRYIIRGKYEIE-DDEGRNTIEITELPYQVNKAKL 242

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362 241 IEKIADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGIN 300
Cdd:cd00187  243 KEKIAELVKDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGIN 302
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
1-300 2.04e-174

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 488.98  E-value: 2.04e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362    1 ALPDVRDGLKPVHRRILYAMNDLgMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV 80
Cdd:pfam00521   2 AIPDVRDGLKPVQRRILYAMFEL-LNLDKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362   81 -DGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEII 159
Cdd:pfam00521  81 iDGDKDAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREII 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  160 DGVLAVSENPDITIpeLMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQtssgKERIIVTELPYQVNKAK 239
Cdd:pfam00521 161 DALIALLDGPEATL--LMKYIMGPDFPTGGGIIGKGGIKEAYKTGRGKITVRAKVEIED----RKTIVITELPYGVWTSD 234

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 410027362  240 LIEKIADLVRDKKIEGITDLRDESDRtGMRIVIEIRRDANANVILNNLYKQTALQTSFGIN 300
Cdd:pfam00521 235 LIEKIEELVKNGKIKGISDIRDESDR-GVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTN 294
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 1-300 5.20e-173

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 485.92  E-value: 5.20e-173
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362     1 ALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV 80
Cdd:smart00434  23 AIPDVRDGLKPVQRRILYAMFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIVRMAQDFSNNYPLLDGQGNFGSR 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362    81 -DGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEII 159
Cdd:smart00434 103 lDGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVNGSSGIAVGMATNIPPHNLREVI 182

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362   160 DGVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSgirkayesgrgSITIRAKAEIEqtssGKERIIVTELPYQVNKAK 239
Cdd:smart00434 183 DAVRRLIDNPDASIDELMMIPWGPDFPTGGEIVGPG-----------KYVVRGKIEIE----DDNTIVITELPYQVNTAD 247

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 410027362   240 LIEKIADLVRDKKIEGITDLRDES-DRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGIN 300
Cdd:smart00434 248 LIEKIAELVKDKKIEGIIDVRDEShDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTTFSIN 309
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 1-300 0e+00

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 704.87  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362   1 ALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV 80
Cdd:PRK05560  30 ALPDVRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSI 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  81 DGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIID 160
Cdd:PRK05560 110 DGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVID 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362 161 GVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTsSGKERIIVTELPYQVNKAKL 240
Cdd:PRK05560 190 ACLALIDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKAEIEEI-KGREAIIVTEIPYQVNKARL 268

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362 241 IEKIADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGIN 300
Cdd:PRK05560 269 IEKIAELVKEKKIEGISDLRDESDRDGMRIVIELKRDAVPEVVLNNLYKHTQLQTSFGIN 328
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-300 0e+00

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 691.40  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362   1 ALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV 80
Cdd:COG0188   35 ALPDVRDGLKPVHRRILYAMHELGLTPDKPYKKSARVVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSI 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  81 DGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIID 160
Cdd:COG0188  115 DGDPAAAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVID 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362 161 GVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKL 240
Cdd:COG0188  195 ACIALIDNPDATIEELMEYIPGPDFPTGGIIVGREGIREAYETGRGSIRVRAKAEIEELKRGREQIVVTEIPYQVNKARL 274

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362 241 IEKIADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGIN 300
Cdd:COG0188  275 IEKIAELVKEKKIEGISDVRDESDRDGMRIVIELKRDANPEVVLNQLYKHTQLQTSFGIN 334
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 1-300 0e+00

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 617.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362    1 ALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV 80
Cdd:TIGR01063  26 ALPDVRDGLKPVHRRILYAMYELGLTPDKPYKKSARIVGDVMGKYHPHGDSAIYDTLVRMAQDFSLRYPLVDGQGNFGSI 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362   81 DGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIID 160
Cdd:TIGR01063 106 DGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLLVNGSSGIAVGMATNIPPHNLGEIID 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  161 GVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKL 240
Cdd:TIGR01063 186 ALLAYIDNPDISIQELLEVIKGPDFPTGGIILGRSGIRSAYETGRGSIVIRARAEIEEDSKGREAIIVTEIPYQVNKARL 265

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  241 IEKIADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGIN 300
Cdd:TIGR01063 266 IEKIAELVREKKIEGISDIRDESDREGIRIVIELKRDAVAEVVLNNLYKQTQLQVSFGIN 325
PRK05561 PRK05561
DNA topoisomerase 4 subunit A;
1-300 0e+00

DNA topoisomerase 4 subunit A;


Pssm-ID: 235503 [Multi-domain]  Cd Length: 742  Bit Score: 576.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362   1 ALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV 80
Cdd:PRK05561  35 ALPDVRDGLKPVQRRILYAMSELGLTPDAKFKKSARVVGDVLGKYHPHGDSSIYDAMVRMAQDFSYRYPLVDGQGNFGSI 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  81 DGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIID 160
Cdd:PRK05561 115 DGDPAAAMRYTEARLSPIAELLLEEIDEGTVDFVPNFDGTLKEPTVLPARFPNLLLNGATGIAVGMATDIPPHNLREVID 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362 161 GVLAVSENPDITIPELMEVIPGPDFPTAGQIL-GRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAK 239
Cdd:PRK05561 195 AAIHLIDNPDATLEELMEFVPGPDFPTGGEIItGRDGIRKAYETGRGSIRVRARWEIEDLAGGRWQIVITELPYQVSKAK 274

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 410027362 240 LIEKIADLVRDKKIEGITDLRDESDRTG-MRIVIEIR-RDANANVILNNLYKQTALQTSFGIN 300
Cdd:PRK05561 275 LIEQIAELMNAKKLPGIADVRDESDRENpVRIVIEPKsNRVDPEALMNHLFATTDLESSYRVN 337
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 1-300 0e+00

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 545.62  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362   1 ALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV 80
Cdd:cd00187    4 ALPDVRDGLKPVQRRILYAMFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNFGSR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  81 DGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIID 160
Cdd:cd00187   84 DGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLREVID 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362 161 GVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEqTSSGKERIIVTELPYQVNKAKL 240
Cdd:cd00187  164 ALRALIDNPEASIDELMEIIKGPDFPTGGIIEGRAGIREAYETGRGRYIIRGKYEIE-DDEGRNTIEITELPYQVNKAKL 242

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362 241 IEKIADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGIN 300
Cdd:cd00187  243 KEKIAELVKDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGIN 302
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
1-300 2.04e-174

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 488.98  E-value: 2.04e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362    1 ALPDVRDGLKPVHRRILYAMNDLgMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV 80
Cdd:pfam00521   2 AIPDVRDGLKPVQRRILYAMFEL-LNLDKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362   81 -DGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEII 159
Cdd:pfam00521  81 iDGDKDAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREII 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  160 DGVLAVSENPDITIpeLMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQtssgKERIIVTELPYQVNKAK 239
Cdd:pfam00521 161 DALIALLDGPEATL--LMKYIMGPDFPTGGGIIGKGGIKEAYKTGRGKITVRAKVEIED----RKTIVITELPYGVWTSD 234

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 410027362  240 LIEKIADLVRDKKIEGITDLRDESDRtGMRIVIEIRRDANANVILNNLYKQTALQTSFGIN 300
Cdd:pfam00521 235 LIEKIEELVKNGKIKGISDIRDESDR-GVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTN 294
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 1-300 5.20e-173

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 485.92  E-value: 5.20e-173
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362     1 ALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV 80
Cdd:smart00434  23 AIPDVRDGLKPVQRRILYAMFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIVRMAQDFSNNYPLLDGQGNFGSR 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362    81 -DGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEII 159
Cdd:smart00434 103 lDGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVNGSSGIAVGMATNIPPHNLREVI 182

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362   160 DGVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSgirkayesgrgSITIRAKAEIEqtssGKERIIVTELPYQVNKAK 239
Cdd:smart00434 183 DAVRRLIDNPDASIDELMMIPWGPDFPTGGEIVGPG-----------KYVVRGKIEIE----DDNTIVITELPYQVNTAD 247

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 410027362   240 LIEKIADLVRDKKIEGITDLRDES-DRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGIN 300
Cdd:smart00434 248 LIEKIAELVKDKKIEGIIDVRDEShDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTTFSIN 309
PRK13979 PRK13979
DNA topoisomerase IV subunit A; Provisional
 1-300 4.37e-150

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 237576 [Multi-domain]  Cd Length: 957  Bit Score: 444.55  E-value: 4.37e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362   1 ALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV 80
Cdd:PRK13979  38 ALPDVRDGLKPVHRRILYGAYMLKAFPDKPYYKSARIVGDILGKYHPHGDSSVYDAMVILAQDFTTRMPLIDGHGNWGSI 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  81 DGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIID 160
Cdd:PRK13979 118 DGDSAAAMRYTEARLTPIAMEMLRDIDKDVVNMVDNYSDSEKEPEVLPARYPNLLVNGAFGIAVGLATNIPPHNLKEVID 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362 161 GVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKL 240
Cdd:PRK13979 198 GTLAYIDNNEITTKELMNYIKGPDLPTGGILIGKKSLLSAYETGEGKVTLRAKTKIEKLENGRLGIVITEFPYRRNKAKL 277

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 410027362 241 IEKIADLVRDKK----IEGITDLRDESDRTGMRIVIEIRRDAN---ANVILNNLYKQTALQTSFGIN 300
Cdd:PRK13979 278 LQTISEMTADKKhskaLENISDIRDESDRNGIRAVIEFKKSADedvAEKVLKYLYKKTDLQCNISFN 344
parC_Gpos TIGR01061
DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II ...
 1-300 3.18e-145

DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273422 [Multi-domain]  Cd Length: 738  Bit Score: 425.76  E-value: 3.18e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362    1 ALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV 80
Cdd:TIGR01061  26 ALPDIRDGLKPVQRRILYAMFQDGNTFDKPYKKSARTVGEIMGKYHPHGDSSIYDAMVRMSQDWKNNWTLVEMHGNNGSI 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362   81 DGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIID 160
Cdd:TIGR01061 106 DGDNAAAMRYTEARLSLIASELLKDIDKKTVSFIPNFDDSEKEPTVLPALFPNLLINGATGIAAGYATNIPPHNLNEVID 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  161 GVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKL 240
Cdd:TIGR01061 186 ALIYRIDHPNCSVDKLMEIVKGPDFPTGGIIQGEDGISKAYETGKGKFIIRAKIEIEVNKNGLNQIVITEIPYETNKANI 265

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  241 IEKIADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGIN 300
Cdd:TIGR01061 266 VKKIEEIIFDNKVAGIEEVRDESDRNGIRIIIELKKDANAEKILNFLFKHTDLQINYNFN 325
parC_Gneg TIGR01062
DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II ...
 1-300 3.94e-130

DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 130134 [Multi-domain]  Cd Length: 735  Bit Score: 386.96  E-value: 3.94e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362    1 ALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV 80
Cdd:TIGR01062  26 ALPFIGDGLKPVQRRIVYAMSELGLNANAKYKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAP 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362   81 DG-DSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEII 159
Cdd:TIGR01062 106 DDpKSFAAMRYTESRLSKISELLLEELGQGTVDFRPNFDGTLLEPVILPARLPNILLNGTTGIAVGMATDIPPHNLHELA 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  160 DGVLAVSENPDITIPELMEVIPGPDFPTAGQILG-RSGIRKAYESGRGSITIRAKAEIEQTSsgkerIIVTELPYQVNKA 238
Cdd:TIGR01062 186 DAALYLIDNPKAGLDDILNIVQGPDFPTEAEIIDkAEEIRKIYETGRGSFRMRARWKKEDGQ-----IVISALPHQISKS 260

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 410027362  239 KLIEKIADLVRDKKIEGITDLRDESDRTG-MRIVIEIR-RDANANVILNNLYKQTALQTSFGIN 300
Cdd:TIGR01062 261 KVIEQIAIQMKDKKLPMISDIRDESDHENpIRVVIVPRsNRVDPDIVMEHLFATTDLEKSYRLN 324
PRK09631 PRK09631
DNA topoisomerase IV subunit A; Provisional
 1-300 2.83e-59

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 236598 [Multi-domain]  Cd Length: 635  Bit Score: 199.93  E-value: 2.83e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362   1 ALPDVRDGLKPVHRRILYAMNDLgmtSDKPYKKSARIVGEVIgKYHPHGDSAVYESMVRMA-QDFnyrymLVDGHGNFGS 79
Cdd:PRK09631  24 AIPDVIDGLKPVQRRILHSLFEM---HDGKFHKVANVVGNTM-KYHPHGDASIYEALVNLAnKDL-----FIDKQGNFGN 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  80 V-DGDSAAAMRYTEARMSKISMEIL--RDITkdtiDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLG 156
Cdd:PRK09631  95 LfTGDPASAARYIECRLTPLAKEVLynKEIT----EYEPSYDGRNNEPLCLPAKIPVILIQGAEGIAVGMATKILPHNFN 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362 157 EIIDGVLAVSENPDITIPelmevipgPDFPTAGqILGRSGirkaYESGRGSITIRAKAEIeqtsSGKERIIVTELPYQVN 236
Cdd:PRK09631 171 EILQAVKSELLGESFALY--------PDFPTGG-IVDVSE----YADGNGKVLVRAKIET----KDEKTIVIREIPFGTT 233

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 410027362 237 KAKLIEKIADLVRDKKIEgITDLrdeSDRTGMRIVIEIR--RDANANVILNNLYKQTALQTSFGIN 300
Cdd:PRK09631 234 TESLIASIEKAARKGKIK-ISSI---NDYTAENVEIEIKlpRGVYASEVIEALYAYTDCEVSISVN 295
PRK12758 PRK12758
DNA gyrase/topoisomerase IV subunit A;
1-244 1.45e-53

DNA gyrase/topoisomerase IV subunit A;


Pssm-ID: 237192 [Multi-domain]  Cd Length: 869  Bit Score: 187.13  E-value: 1.45e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362   1 ALPDVRDGLKPVHRRILYAMNDLgmtSDKPYKKSARIVGEVIgKYHPHGDSAVYESMVRMAQdfnyRYMLVDGHGNFGSV 80
Cdd:PRK12758  43 AVPHIEDGLKPVQRRILHSMKEM---DDGRYNKVANVVGHTM-QYHPHGDASIGDALVQLGQ----KDLLIDTQGNWGNI 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  81 -DGDSAAAMRYTEARMSKISMEILrdITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEII 159
Cdd:PRK12758 115 lTGDGAAAPRYIEARLSKFALEVV--FNPKTTEWQLSYDGRKKEPVTLPVKFPLLLAQGAEGIAVGLSTKILPHNFNELI 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362 160 DGVLAVSENPDITIPelmevipgPDFPTAGqILGRSgirkAYESGR--GSITIRAKaeIEQTSsgKERIIVTELPYQVNK 237
Cdd:PRK12758 193 DASIAYLKGKEFKLY--------PDFPTGG-IIDVS----NYNDGErgGRVRVRAK--IEKLD--KKTLVITEIPYGTTT 255


                 ....*..
gi 410027362 238 AKLIEKI 244
Cdd:PRK12758 256 SSLIDSI 262
PRK09630 PRK09630
DNA topoisomerase IV subunit A; Provisional
 1-294 5.58e-45

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 170022  Cd Length: 479  Bit Score: 158.90  E-value: 5.58e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362   1 ALPDVRDGLKPVHRRILYAmndLGMTSDKPYKKSARIVGEVIGkYHPHGDSAVYESMVRMAqdfNYRYmLVDGHGNFGS- 79
Cdd:PRK09630  24 AIPHILDGLKPVQRRLLWT---LFRMDDGKMHKVANIAGRTMA-LHPHGDAPIVEALVVLA---NKGY-LIDTQGNFGNp 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  80 VDGDSAAAMRYTEARMSKISMEILrdITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEII 159
Cdd:PRK09630  96 LTGDPHAAARYIEARLSPLAKEVL--FNTDLMTFHDSYDGREKEPDILPAKLPLLLLHGVDGIAVGMTTKIFPHNFCELL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362 160 DGVLAVSENPDITIPelmevipgPDFPTAGQILGRSgirkaYESGRGSITIRAKAEIEQTSSgkerIIVTELPYQVNKAK 239
Cdd:PRK09630 174 EAQIAILNDQPFTLL--------PDFPSGGTMDASE-----YQDGLGSITLRASIDIINDKT----LLIKEICPSTTTET 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 410027362 240 LIEKIADLVRDK--KIEGITDLRDESDrtgmRIVIEIRRDANANVILNNLYKQTALQ 294
Cdd:PRK09630 237 LIRSIENAAKRGiiKIDSIQDFSTDLP----HIEIKLPKGIYAKDLLRPLFTHTECQ 289
52 PHA02592
DNA topisomerase II medium subunit; Provisional
 1-282 2.40e-37

DNA topisomerase II medium subunit; Provisional


Pssm-ID: 222896 [Multi-domain]  Cd Length: 439  Bit Score: 137.50  E-value: 2.40e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362   1 ALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEV--IGkYHpHGDSAVYESMVRMAQDFNYRYMLVDGHGNFG 78
Cdd:PHA02592  28 AIPNLIDGLKPVQRFVIHRALEYAKGNKEKFDKVAAIAGGVadLG-YH-HGETSAQDAGALMANTWNNNIPLLDGQGNFG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  79 SVDGDSAAAMRYTEARMSkismEILRDITKDtIDYQDNYDGSERepvvMPSRF-----PNLLVNGAAGIAVGMATNIPPH 153
Cdd:PHA02592 106 SRLVQKAAAARYIFARVH----DNFRKIYKD-EDLAPVHEDPEH----IPPAFylpiiPMVLLNGVSGIATGYATNILPH 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362 154 QLGEIIDGVLAVSENPDITIPElmevipgPDFPtagqilGRSGirKAYESGRGSITIRAKAEIeqtsSGKERIIVTELPY 233
Cdd:PHA02592 177 SPKSVIKAVLAALNGKDITEPK-------VQFP------EFKG--EVVEIEPGSYEIRGTYEL----NGKTKLHITEIPV 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 410027362 234 QVNKAKLIEKIADLVRDKKIEGITDLRDEsdrtGMRIVIEIRRDANANV 282
Cdd:PHA02592 238 KYDRETYVAVLDPLEEKGKIVSYDDCTED----GFRFKVTLKREENEEA 282
PLN03128 PLN03128
DNA topoisomerase 2; Provisional
 2-296 4.45e-22

DNA topoisomerase 2; Provisional


Pssm-ID: 215593 [Multi-domain]  Cd Length: 1135  Bit Score: 96.32  E-value: 4.45e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362    2 LPDVRDGLKPVHRRILYAMNDLGMTSDKpykKSARIVGEVI--GKYHpHGDSAVYESMVRMAQDF---NYRYMLVDgHGN 76
Cdd:PLN03128  675 IPSMVDGLKPSQRKVLFACFKRNLKSEI---KVAQLSGYVAehSAYH-HGEASLASTIIGMAQDFvgsNNINLLTP-SGQ 749

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362   77 FGS--VDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNyDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQ 154
Cdd:PLN03128  750 FGTrlQGGKDAASARYIFTRLSPITRALFPKDDDVLLNYLNE-DGQSIEPEWYCPIIPMVLVNGSEGIGTGWSTFIPNYN 828

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  155 LGEIIDGVLAVSENPDitiPELMEvipgpdfPTAGQILGRsgIRKAYESGRGSITIRAKAEIEQTSSgkerIIVTELPYQ 234
Cdd:PLN03128  829 PRDIIANIRRLLRGEE---LEPMH-------PWYRGFKGT--ITEVSTSRSGSYTVTGIIEQIGDTT----IRITELPVR 892

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 410027362  235 V---NKAKLIEKIADLVRDKKIEgITDLRDESDRTGMRIVIEIRRDANANVILNNLYK----QTALQTS 296
Cdd:PLN03128  893 KwtqDYKEFLEALLTGTKKKEPE-IKDFKENHTDTTVHFTVTLSEEKMARALAEGLEKkfklSTTISTS 960
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 1-300 8.18e-20

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 89.72  E-value: 8.18e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362    1 ALPDVRDGLKPVHRRILYAM------NDLgmtsdkpykKSARIVGEVIGK--YHpHGDSAVYESMVRMAQDF----NYRY 68
Cdd:PTZ00108  681 SIPSLVDGLKPGQRKILFACfkrnlkNEI---------KVAQLSGYVSEHsaYH-HGEQSLQQTIVGMAQNFvgsnNINL 750

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362   69 MLVDGHgnFGS--VDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNyDGSEREPVVMPSRFPNLLVNGAAGIAVGM 146
Cdd:PTZ00108  751 LYPCGQ--FGSrlQGGKDHAAARYIFTKLSKITRYIFPEEDDPILDYLED-DGQSVEPFYYVPIIPMVLVNGAEGIGTGF 827

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  147 ATNIPPHQLGEIIDGVLAVSENpditiPELMEVIPgpdfptagqilgrsgirkAYESGRGSITIRAKAEIEqtSSGK--- 223
Cdd:PTZ00108  828 STSIPNYNPLDIIDNLRRRLNG-----EEVRPLVP------------------WYRGFKGTIERNPKGKFI--SKGIyek 882

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  224 ---ERIIVTELPYQV---NKAKLIEKIAdlvrDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSF 297
Cdd:PTZ00108  883 vpdGTVEITELPIGKwteDYKEFLESET----LKEKDVIVDYRDYSTANTVHFTVKLNDGVLEQWEEEGIEKVFKLKSTI 958


                  ...
gi 410027362  298 GIN 300
Cdd:PTZ00108  959 STT 961
PLN03237 PLN03237
DNA topoisomerase 2; Provisional
 1-272 2.47e-14

DNA topoisomerase 2; Provisional


Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 73.36  E-value: 2.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362    1 ALPDVRDGLKPVHRRILYAMNDLGMTSDKpykKSARIVGEV--IGKYHpHGDSAVYESMVRMAQDF---NYRYMLVDGhG 75
Cdd:PLN03237  699 SIPSMVDGLKPGQRKILFCSFKRNFVKEA---KVAQLSGYVseHSAYH-HGEQSLASTIIGMAQDFvgsNNINLLLPN-G 773

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362   76 NFG--SVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNyDGSEREPV-VMPSrFPNLLVNGAAGIAVGMATNIPP 152
Cdd:PLN03237  774 QFGtrLQGGKDHASARYIFTRLSPITRFLFPKDDDILLDYLNE-DGQSIEPTwYMPI-IPTVLVNGAEGIGTGWSTFIPN 851

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410027362  153 HQLGEIIDGVLAVSENpditipELMEvipgPDFPTagqilgrsgirkaYESGRGSI--TIRAKAEIEQTSSGK------E 224
Cdd:PLN03237  852 YNPRDIVANIRRLLNG------ESME----PMHPW-------------YRGFKGTIekTASKEGGCTYTITGLyeevdeT 908

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 410027362  225 RIIVTELP---YQVNKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRIVI 272
Cdd:PLN03237  909 TLRITELPirrWTDDYKEFLESLKTDNNKNKDPFIKDVKAYNDDTTVHFEV 959
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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