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Conserved domains on  [gi|452076209|gb|AGF92670|]
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gamma-tocopherol methyltransferase [Zea mays subsp. mays]

Protein Classification

SAM-dependent methyltransferase( domain architecture ID 11476565)

SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02244 PLN02244
tocopherol O-methyltransferase
 11-350 0e+00

tocopherol O-methyltransferase


:

Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 618.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209  11 QSSRSLAACRRGSHYP--APSHVPRHSRRRRRAVVSLRPMASST--AQAPATAPPGLKEGIAGLYDESSGLWENIWGDHM 86
Cdd:PLN02244   1 SPAAALASRSSSSATTsrSGSRSTRLSRPSSSASGVRRTLARLEdaASPAPAATADLKEGIAEFYDESSGVWEDVWGEHM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209  87 HHGFYDssEAASMADHRRAQIRMIEEALAFAGVPasDDPENTPKTIVDVGCGIGGSSRYLAKKYGAQCTGITLSPVQAER 166
Cdd:PLN02244  81 HHGYYD--PGASRGDHRQAQIRMIEESLAWAGVP--DDDEKRPKRIVDVGCGIGGSSRYLARKYGANVKGITLSPVQAAR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 167 GNALAGAQGLSDQVTLQVADALEQPFPDGQFDLVWSMESGEHMPDKRKFVSELARVAAPGGTIIIVTWCHRNLDPSETSL 246
Cdd:PLN02244 157 ANALAAAQGLSDKVSFQVADALNQPFEDGQFDLVWSMESGEHMPDKRKFVQELARVAAPGGRIIIVTWCHRDLEPGETSL 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 247 KPDELSLLKRICDAYYLPDWCSPSDYVNIAKSLSLEDIKTADWSENVAPFWPAVIKSALTWKGFTSLLTTGWKTIRGAMV 326
Cdd:PLN02244 237 KPDEQKLLDKICAAYYLPAWCSTSDYVKLAESLGLQDIKTEDWSEHVAPFWPAVIKSALTLKGLFGLLTSGWATIRGALV 316

                        330       340
                 ....*....|....*....|....
gi 452076209 327 MPLMIQGYKKGLIKFTIITCRKPG 350
Cdd:PLN02244 317 MPLMIKGFKKGLIKFAVITCRKPL 340
 
Name Accession Description Interval E-value
PLN02244 PLN02244
tocopherol O-methyltransferase
 11-350 0e+00

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 618.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209  11 QSSRSLAACRRGSHYP--APSHVPRHSRRRRRAVVSLRPMASST--AQAPATAPPGLKEGIAGLYDESSGLWENIWGDHM 86
Cdd:PLN02244   1 SPAAALASRSSSSATTsrSGSRSTRLSRPSSSASGVRRTLARLEdaASPAPAATADLKEGIAEFYDESSGVWEDVWGEHM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209  87 HHGFYDssEAASMADHRRAQIRMIEEALAFAGVPasDDPENTPKTIVDVGCGIGGSSRYLAKKYGAQCTGITLSPVQAER 166
Cdd:PLN02244  81 HHGYYD--PGASRGDHRQAQIRMIEESLAWAGVP--DDDEKRPKRIVDVGCGIGGSSRYLARKYGANVKGITLSPVQAAR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 167 GNALAGAQGLSDQVTLQVADALEQPFPDGQFDLVWSMESGEHMPDKRKFVSELARVAAPGGTIIIVTWCHRNLDPSETSL 246
Cdd:PLN02244 157 ANALAAAQGLSDKVSFQVADALNQPFEDGQFDLVWSMESGEHMPDKRKFVQELARVAAPGGRIIIVTWCHRDLEPGETSL 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 247 KPDELSLLKRICDAYYLPDWCSPSDYVNIAKSLSLEDIKTADWSENVAPFWPAVIKSALTWKGFTSLLTTGWKTIRGAMV 326
Cdd:PLN02244 237 KPDEQKLLDKICAAYYLPAWCSTSDYVKLAESLGLQDIKTEDWSEHVAPFWPAVIKSALTLKGLFGLLTSGWATIRGALV 316

                        330       340
                 ....*....|....*....|....
gi 452076209 327 MPLMIQGYKKGLIKFTIITCRKPG 350
Cdd:PLN02244 317 MPLMIKGFKKGLIKFAVITCRKPL 340
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 71-233 1.46e-41

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 142.76  E-value: 1.46e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209  71 YDESSGLWENIWGDHMH-HGFYDSSEAASMADhrrAQIRMIEEALAFAGVPASDdpentpkTIVDVGCGIGGSSRYLAKK 149
Cdd:COG2230    3 YDLGNDFYRLFLDPTMTySCAYFEDPDDTLEE---AQEAKLDLILRKLGLKPGM-------RVLDIGCGWGGLALYLARR 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 150 YGAQCTGITLSPVQAERGNALAGAQGLSDQVTLQVADALEQPfPDGQFDLVWSMESGEHMPDK--RKFVSELARVAAPGG 227
Cdd:COG2230   73 YGVRVTGVTLSPEQLEYARERAAEAGLADRVEVRLADYRDLP-ADGQFDAIVSIGMFEHVGPEnyPAYFAKVARLLKPGG 151


                 ....*.
gi 452076209 228 TIIIVT 233
Cdd:COG2230  152 RLLLHT 157
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 132-227 8.49e-29

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 106.88  E-value: 8.49e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209  132 IVDVGCGIGGSSRYLAKKYGAQCTGITLSPVQAERGNALAGAQGLsdQVTLQVADALEQPFPDGQFDLVWSMESGEHM-- 209
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLpd 78

                          90
                  ....*....|....*...
gi 452076209  210 PDKRKFVSELARVAAPGG 227
Cdd:pfam13649  79 PDLEAALREIARVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 131-234 3.58e-16

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 73.23  E-value: 3.58e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 131 TIVDVGCGIGGSSRYLAKKYGAQCTGITLSPVQAERGNALAgAQGLSDQVTLQVADALE-QPFPDGQFDLVWSMESGEH- 208
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAA-AALLADNVEVLKGDAEElPPEADESFDVIISDPPLHHl 79

                         90       100
                 ....*....|....*....|....*.
gi 452076209 209 MPDKRKFVSELARVAAPGGTIIIVTW 234
Cdd:cd02440   80 VEDLARFLEEARRLLKPGGVLVLTLV 105
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 129-261 2.90e-11

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 62.28  E-value: 2.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209  129 PKTIVDVGCGIGGSSRYLAKKYG--AQCTGITLSPvqaergNALAGAQ---GLSDQVTLQVADALEQPFPDGQFDLVwSM 203
Cdd:TIGR01934  40 GQKVLDVACGTGDLAIELAKSAPdrGKVTGVDFSS------EMLEVAKkksELPLNIEFIQADAEALPFEDNSFDAV-TI 112

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 452076209  204 ESG-EHMPDKRKFVSELARVAAPGGTIIIvtwchrnLDPSetslKPDElSLLKRICDAY 261
Cdd:TIGR01934 113 AFGlRNVTDIQKALREMYRVLKPGGRLVI-------LEFS----KPAN-ALLKKFYKFY 159
PKS_MT smart00828
Methyltransferase in polyketide synthase (PKS) enzymes;
130-231 3.72e-10

Methyltransferase in polyketide synthase (PKS) enzymes;


Pssm-ID: 214839 [Multi-domain]  Cd Length: 224  Bit Score: 59.35  E-value: 3.72e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209   130 KTIVDVGCGIGGSSRYLAKKYGA-QCTGITLSPVQAERGNALAGAQGLSDQVTLQVADALEQPFPDgQFDLVWSMESGEH 208
Cdd:smart00828   1 KRVLDFGCGYGSDLIDLAERHPHlQLHGYTISPEQAEVGRERIRALGLQGRIRIFYRDSAKDPFPD-TYDLVFGFEVIHH 79

                           90       100
                   ....*....|....*....|...
gi 452076209   209 MPDKRKFVSELARVAAPGGTIII 231
Cdd:smart00828  80 IKDKMDLFSNISRHLKDGGHLVL 102
 
Name Accession Description Interval E-value
PLN02244 PLN02244
tocopherol O-methyltransferase
 11-350 0e+00

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 618.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209  11 QSSRSLAACRRGSHYP--APSHVPRHSRRRRRAVVSLRPMASST--AQAPATAPPGLKEGIAGLYDESSGLWENIWGDHM 86
Cdd:PLN02244   1 SPAAALASRSSSSATTsrSGSRSTRLSRPSSSASGVRRTLARLEdaASPAPAATADLKEGIAEFYDESSGVWEDVWGEHM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209  87 HHGFYDssEAASMADHRRAQIRMIEEALAFAGVPasDDPENTPKTIVDVGCGIGGSSRYLAKKYGAQCTGITLSPVQAER 166
Cdd:PLN02244  81 HHGYYD--PGASRGDHRQAQIRMIEESLAWAGVP--DDDEKRPKRIVDVGCGIGGSSRYLARKYGANVKGITLSPVQAAR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 167 GNALAGAQGLSDQVTLQVADALEQPFPDGQFDLVWSMESGEHMPDKRKFVSELARVAAPGGTIIIVTWCHRNLDPSETSL 246
Cdd:PLN02244 157 ANALAAAQGLSDKVSFQVADALNQPFEDGQFDLVWSMESGEHMPDKRKFVQELARVAAPGGRIIIVTWCHRDLEPGETSL 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 247 KPDELSLLKRICDAYYLPDWCSPSDYVNIAKSLSLEDIKTADWSENVAPFWPAVIKSALTWKGFTSLLTTGWKTIRGAMV 326
Cdd:PLN02244 237 KPDEQKLLDKICAAYYLPAWCSTSDYVKLAESLGLQDIKTEDWSEHVAPFWPAVIKSALTLKGLFGLLTSGWATIRGALV 316

                        330       340
                 ....*....|....*....|....
gi 452076209 327 MPLMIQGYKKGLIKFTIITCRKPG 350
Cdd:PLN02244 317 MPLMIKGFKKGLIKFAVITCRKPL 340
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 71-233 1.46e-41

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 142.76  E-value: 1.46e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209  71 YDESSGLWENIWGDHMH-HGFYDSSEAASMADhrrAQIRMIEEALAFAGVPASDdpentpkTIVDVGCGIGGSSRYLAKK 149
Cdd:COG2230    3 YDLGNDFYRLFLDPTMTySCAYFEDPDDTLEE---AQEAKLDLILRKLGLKPGM-------RVLDIGCGWGGLALYLARR 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 150 YGAQCTGITLSPVQAERGNALAGAQGLSDQVTLQVADALEQPfPDGQFDLVWSMESGEHMPDK--RKFVSELARVAAPGG 227
Cdd:COG2230   73 YGVRVTGVTLSPEQLEYARERAAEAGLADRVEVRLADYRDLP-ADGQFDAIVSIGMFEHVGPEnyPAYFAKVARLLKPGG 151


                 ....*.
gi 452076209 228 TIIIVT 233
Cdd:COG2230  152 RLLLHT 157
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 94-234 1.46e-29

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 110.47  E-value: 1.46e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209  94 SEAASMADHRRAQIRMIeealafagvpasddPENTPKTIVDVGCGIGGSSRYLAKKyGAQCTGITLSPVQAERGNALAGA 173
Cdd:COG2226    2 DRVAARYDGREALLAAL--------------GLRPGARVLDLGCGTGRLALALAER-GARVTGVDISPEMLELARERAAE 66

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 452076209 174 QGLsdQVTLQVADALEQPFPDGQFDLVWSMESGEHMPDKRKFVSELARVAAPGGTIIIVTW 234
Cdd:COG2226   67 AGL--NVEFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDF 125
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 132-227 8.49e-29

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 106.88  E-value: 8.49e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209  132 IVDVGCGIGGSSRYLAKKYGAQCTGITLSPVQAERGNALAGAQGLsdQVTLQVADALEQPFPDGQFDLVWSMESGEHM-- 209
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLpd 78

                          90
                  ....*....|....*...
gi 452076209  210 PDKRKFVSELARVAAPGG 227
Cdd:pfam13649  79 PDLEAALREIARVLKPGG 96
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 129-233 1.16e-27

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 105.10  E-value: 1.16e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 129 PKTIVDVGCGIGGSSRYLAKKyGAQCTGITLSPVQAERGNALAGAQGlsdqVTLQVADALEQPFPDGQFDLVWSMESGEH 208
Cdd:COG2227   25 GGRVLDVGCGTGRLALALARR-GADVTGVDISPEALEIARERAAELN----VDFVQGDLEDLPLEDGSFDLVICSEVLEH 99

                         90       100
                 ....*....|....*....|....*
gi 452076209 209 MPDKRKFVSELARVAAPGGTIIIVT 233
Cdd:COG2227  100 LPDPAALLRELARLLKPGGLLLLST 124
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 133-231 1.94e-26

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 100.82  E-value: 1.94e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209  133 VDVGCGIGGSSRYLAKkYGAQCTGITLSPVQAERGNALAGAQGLsdqvTLQVADALEQPFPDGQFDLVWSMESGEHMPDK 212
Cdd:pfam08241   1 LDVGCGTGLLTELLAR-LGARVTGVDISPEMLELAREKAPREGL----TFVVGDAEDLPFPDNSFDLVLSSEVLHHVEDP 75

                          90
                  ....*....|....*....
gi 452076209  213 RKFVSELARVAAPGGTIII 231
Cdd:pfam08241  76 ERALREIARVLKPGGILII 94
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 127-232 1.84e-21

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 90.75  E-value: 1.84e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 127 NTPKTIVDVGCGIGGSSRYLAKKYGAQCTGITLSPVQAERGNALAGAQGLSdQVTLQVADALE-QPFPDGQFDLVWSMES 205
Cdd:COG0500   25 PKGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGLG-NVEFLVADLAElDPLPAESFDLVVAFGV 103

                         90       100
                 ....*....|....*....|....*....
gi 452076209 206 GEHMP--DKRKFVSELARVAAPGGTIIIV 232
Cdd:COG0500  104 LHHLPpeEREALLRELARALKPGGVLLLS 132
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
129-233 1.83e-20

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 84.88  E-value: 1.83e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 129 PKTIVDVGCGIGGSSRYLAKKY-GAQCTGITLSPvqaergNALAGAQGLSDQVTLQVADALEQPfPDGQFDLVWSMESGE 207
Cdd:COG4106    2 PRRVLDLGCGTGRLTALLAERFpGARVTGVDLSP------EMLARARARLPNVRFVVADLRDLD-PPEPFDLVVSNAALH 74

                         90       100
                 ....*....|....*....|....*.
gi 452076209 208 HMPDKRKFVSELARVAAPGGTIIIVT 233
Cdd:COG4106   75 WLPDHAALLARLAAALAPGGVLAVQV 100
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
63-234 1.46e-18

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 81.97  E-value: 1.46e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209  63 LKEGIAGLYDESSGLWENIWGDHMHhgfYDSSEaasmadhrraqiRMIEEALAFAgvpasddPENTPKTIVDVGCGIGGS 142
Cdd:COG4976    3 LDAYVEALFDQYADSYDAALVEDLG---YEAPA------------LLAEELLARL-------PPGPFGRVLDLGCGTGLL 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 143 SRYLAKkYGAQCTGITLSPvqaergNALAGAQGLSDQVTLQVADALEQPFPDGQFDLVWSMESGEHMPDKRKFVSELARV 222
Cdd:COG4976   61 GEALRP-RGYRLTGVDLSE------EMLAKAREKGVYDRLLVADLADLAEPDGRFDLIVAADVLTYLGDLAAVFAGVARA 133

                        170
                 ....*....|..
gi 452076209 223 AAPGGTIIIVTW 234
Cdd:COG4976  134 LKPGGLFIFSVE 145
PRK08317 PRK08317
hypothetical protein; Provisional
 131-232 1.11e-17

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 81.14  E-value: 1.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 131 TIVDVGCGIGGSSRYLAKKYGA--QCTGITLSPvqaergNALAGAQ----GLSDQVTLQVADALEQPFPDGQFDLVWSME 204
Cdd:PRK08317  22 RVLDVGCGPGNDARELARRVGPegRVVGIDRSE------AMLALAKeraaGLGPNVEFVRGDADGLPFPDGSFDAVRSDR 95

                         90       100
                 ....*....|....*....|....*...
gi 452076209 205 SGEHMPDKRKFVSELARVAAPGGTIIIV 232
Cdd:PRK08317  96 VLQHLEDPARALAEIARVLRPGGRVVVL 123
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 131-234 3.58e-16

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 73.23  E-value: 3.58e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 131 TIVDVGCGIGGSSRYLAKKYGAQCTGITLSPVQAERGNALAgAQGLSDQVTLQVADALE-QPFPDGQFDLVWSMESGEH- 208
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAA-AALLADNVEVLKGDAEElPPEADESFDVIISDPPLHHl 79

                         90       100
                 ....*....|....*....|....*.
gi 452076209 209 MPDKRKFVSELARVAAPGGTIIIVTW 234
Cdd:cd02440   80 VEDLARFLEEARRLLKPGGVLVLTLV 105
PLN02336 PLN02336
phosphoethanolamine N-methyltransferase
 130-243 9.77e-15

phosphoethanolamine N-methyltransferase


Pssm-ID: 177970 [Multi-domain]  Cd Length: 475  Bit Score: 74.79  E-value: 9.77e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 130 KTIVDVGCGIGGSSRYLAKKYGAQCTGITLSPVQAERgnALAGAQGLSDQVTLQVADALEQPFPDGQFDLVWSMESGEHM 209
Cdd:PLN02336 268 QKVLDVGCGIGGGDFYMAENFDVHVVGIDLSVNMISF--ALERAIGRKCSVEFEVADCTKKTYPDNSFDVIYSRDTILHI 345

                         90       100       110
                 ....*....|....*....|....*....|....
gi 452076209 210 PDKRKFVSELARVAAPGGTIIIVTWCHRNLDPSE 243
Cdd:PLN02336 346 QDKPALFRSFFKWLKPGGKVLISDYCRSPGTPSP 379
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 131-261 2.78e-13

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 68.64  E-value: 2.78e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 131 TIVDVGCGIGGSSRYLAKKYG--AQCTGITLSP----VQAERgnalAGAQGLSDQVTLQVADALEQPFPDGQFDLVwSME 204
Cdd:PRK00216  54 KVLDLACGTGDLAIALAKAVGktGEVVGLDFSEgmlaVGREK----LRDLGLSGNVEFVQGDAEALPFPDNSFDAV-TIA 128

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 452076209 205 SG-EHMPDKRKFVSELARVAAPGGTIIIVtwchrnldpsETSlKPdELSLLKRICDAY 261
Cdd:PRK00216 129 FGlRNVPDIDKALREMYRVLKPGGRLVIL----------EFS-KP-TNPPLKKAYDFY 174
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 133-229 1.60e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 62.77  E-value: 1.60e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209  133 VDVGCGIGGSSRYLAKKY-GAQCTGITLSPVQAERGNALAGAQGLSD--QVTLQVADALEQPFPdgQFDLVWSMESGEHM 209
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALpGLEYTGLDISPAALEAARERLAALGLLNavRVELFQLDLGELDPG--SFDVVVASNVLHHL 78

                          90       100
                  ....*....|....*....|
gi 452076209  210 PDKRKFVSELARVAAPGGTI 229
Cdd:pfam08242  79 ADPRAVLRNIRRLLKPGGVL 98
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 102-235 2.15e-12

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 64.37  E-value: 2.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209  102 HRRAQIRMIEEALAFAGvpasdDPENTPKTIVDVGCGIGGSSRYLaKKYGAQCTGITLSPVQAERGNalagaqglsDQVT 181
Cdd:pfam13489   1 YAHQRERLLADLLLRLL-----PKLPSPGRVLDFGCGTGIFLRLL-RAQGFSVTGVDPSPIAIERAL---------LNVR 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 452076209  182 LQVADALEQPFPDGQFDLVWSMESGEHMPDKRKFVSELARVAAPGGTIIIVTWC 235
Cdd:pfam13489  66 FDQFDEQEAAVPAGKFDVIVAREVLEHVPDPPALLRQIAALLKPGGLLLLSTPL 119
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 105-270 2.23e-12

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 66.58  E-value: 2.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209  105 AQIRMIEEALAFAGVPASDdpentpkTIVDVGCGIGGSSRYLAKKYGAQCTGITLSPVQAERGNALAGAQGLSDQVTLQV 184
Cdd:pfam02353  45 AQQAKLDLILDKLGLKPGM-------TLLDIGCGWGGLMRRAAERYDVNVVGLTLSKNQYKLARKRVAAEGLARKVEVLL 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209  185 ADALEQpfpDGQFDLVWSMESGEHMPDKR--KFVSELARVAAPGGTIIIvtwcHrnldpSETSLKPDELS---LLKRICD 259
Cdd:pfam02353 118 QDYRDF---DEPFDRIVSVGMFEHVGHENydTFFKKLYNLLPPGGLMLL----H-----TITGLHPDETSergLPLKFID 185

                         170
                  ....*....|.
gi 452076209  260 AYYLPDWCSPS 270
Cdd:pfam02353 186 KYIFPGGELPS 196
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 131-240 4.25e-12

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 65.16  E-value: 4.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 131 TIVDVGCGIGGSSRYLaKKYGAQCTGITLSP---VQAERGNAlagAQglsdqvTLQVADALEQPFPDGQFDLVWSMESGE 207
Cdd:PRK10258  45 HVLDAGCGPGWMSRYW-RERGSQVTALDLSPpmlAQARQKDA---AD------HYLAGDIESLPLATATFDLAWSNLAVQ 114

                         90       100       110
                 ....*....|....*....|....*....|...
gi 452076209 208 HMPDKRKFVSELARVAAPGGTIIIVTWCHRNLD 240
Cdd:PRK10258 115 WCGNLSTALRELYRVVRPGGVVAFTTLVQGSLP 147
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 129-261 2.90e-11

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 62.28  E-value: 2.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209  129 PKTIVDVGCGIGGSSRYLAKKYG--AQCTGITLSPvqaergNALAGAQ---GLSDQVTLQVADALEQPFPDGQFDLVwSM 203
Cdd:TIGR01934  40 GQKVLDVACGTGDLAIELAKSAPdrGKVTGVDFSS------EMLEVAKkksELPLNIEFIQADAEALPFEDNSFDAV-TI 112

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 452076209  204 ESG-EHMPDKRKFVSELARVAAPGGTIIIvtwchrnLDPSetslKPDElSLLKRICDAY 261
Cdd:TIGR01934 113 AFGlRNVTDIQKALREMYRVLKPGGRLVI-------LEFS----KPAN-ALLKKFYKFY 159
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 126-233 4.39e-11

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 60.51  E-value: 4.39e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209  126 ENTPKTIVDVGCGIGGSSRYLAKKYGAQC--TGITLSPVQAERGNALAGAQGLSDqVTLQVADA--LEQPFPDGQFDLVW 201
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEELGPNAevVGIDISEEAIEKARENAQKLGFDN-VEFEQGDIeeLPELLEDDKFDVVI 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 452076209  202 SMESGEHMPDKRKFVSELARVAAPGGTIIIVT 233
Cdd:pfam13847  80 SNCVLNHIPDPDKVLQEILRVLKPGGRLIISD 111
PTZ00098 PTZ00098
phosphoethanolamine N-methyltransferase; Provisional
 122-235 2.24e-10

phosphoethanolamine N-methyltransferase; Provisional


Pssm-ID: 173391 [Multi-domain]  Cd Length: 263  Bit Score: 60.37  E-value: 2.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 122 SDDPENTPKTIVDVGCGIGGSSRYLAKKYGAQCTGITLspvqAERGNALAGAQGL-SDQVTLQVADALEQPFPDGQFDLV 200
Cdd:PTZ00098  46 SDIELNENSKVLDIGSGLGGGCKYINEKYGAHVHGVDI----CEKMVNIAKLRNSdKNKIEFEANDILKKDFPENTFDMI 121

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 452076209 201 WSMESGEHMP--DKRKFVSELARVAAPGGTIIIVTWC 235
Cdd:PTZ00098 122 YSRDAILHLSyaDKKKLFEKCYKWLKPNGILLITDYC 158
PKS_MT smart00828
Methyltransferase in polyketide synthase (PKS) enzymes;
130-231 3.72e-10

Methyltransferase in polyketide synthase (PKS) enzymes;


Pssm-ID: 214839 [Multi-domain]  Cd Length: 224  Bit Score: 59.35  E-value: 3.72e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209   130 KTIVDVGCGIGGSSRYLAKKYGA-QCTGITLSPVQAERGNALAGAQGLSDQVTLQVADALEQPFPDgQFDLVWSMESGEH 208
Cdd:smart00828   1 KRVLDFGCGYGSDLIDLAERHPHlQLHGYTISPEQAEVGRERIRALGLQGRIRIFYRDSAKDPFPD-TYDLVFGFEVIHH 79

                           90       100
                   ....*....|....*....|...
gi 452076209   209 MPDKRKFVSELARVAAPGGTIII 231
Cdd:smart00828  80 IKDKMDLFSNISRHLKDGGHLVL 102
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 128-239 2.37e-09

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 56.91  E-value: 2.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209  128 TPKTIVDVGCGIGGSSRYLAKKY-GAQCTGITLSPVQaergnaLAGAQG-LSDQVTLQVADALEQPFPDGQFDLVWSMES 205
Cdd:TIGR02072  34 IPASVLDIGCGTGYLTRALLKRFpQAEFIALDISAGM------LAQAKTkLSENVQFICGDAEKLPLEDSSFDLIVSNLA 107

                          90       100       110
                  ....*....|....*....|....*....|....
gi 452076209  206 GEHMPDKRKFVSELARVAAPGGTIIIVTWCHRNL 239
Cdd:TIGR02072 108 LQWCDDLSQALSELARVLKPGGLLAFSTFGPGTL 141
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 129-242 7.28e-09

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 54.42  E-value: 7.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 129 PKTIVDVGCGIGGSSRYLAK--KYGAQCTGITLSPVQAERGNALAGAQGLSDQVTLQVADALE--QPFPDGQFDLVwsme 204
Cdd:COG4122   17 AKRILEIGTGTGYSTLWLARalPDDGRLTTIEIDPERAAIARENFARAGLADRIRLILGDALEvlPRLADGPFDLV---- 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 452076209 205 sgeHM----PDKRKFVSELARVAAPGGTIII--VTWCHRNLDPS 242
Cdd:COG4122   93 ---FIdadkSNYPDYLELALPLLRPGGLIVAdnVLWHGRVADPA 133
PRK11705 PRK11705
cyclopropane fatty acyl phospholipid synthase;
131-257 2.34e-08

cyclopropane fatty acyl phospholipid synthase;


Pssm-ID: 183282  Cd Length: 383  Bit Score: 55.24  E-value: 2.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 131 TIVDVGCGIGGSSRYLAKKYGAQCTGITLSPVQAERGNALagAQGLSdqVTLQVADALEQpfpDGQFDLVWSMESGEHMP 210
Cdd:PRK11705 170 RVLDIGCGWGGLARYAAEHYGVSVVGVTISAEQQKLAQER--CAGLP--VEIRLQDYRDL---NGQFDRIVSVGMFEHVG 242

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 452076209 211 DK--RKFVselaRVAapggtiiivtwcHRNldpsetsLKPDELSLLKRI 257
Cdd:PRK11705 243 PKnyRTYF----EVV------------RRC-------LKPDGLFLLHTI 268
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 104-233 2.41e-07

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 50.99  E-value: 2.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 104 RAQIR-----MIEEALAFagVPASDDPenTPKTIVDVGCGIGGSSRYLAKKyGAQCTGITLSPVQAERGNALAGAQGLSD 178
Cdd:PRK07580  38 RATVRaghqrMRDTVLSW--LPADGDL--TGLRILDAGCGVGSLSIPLARR-GAKVVASDISPQMVEEARERAPEAGLAG 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 452076209 179 QVTLQVADaLEQpfPDGQFDLVWSMESGEHMPDKrKFVSELARVAAPGGTIIIVT 233
Cdd:PRK07580 113 NITFEVGD-LES--LLGRFDTVVCLDVLIHYPQE-DAARMLAHLASLTRGSLIFT 163
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 115-237 2.52e-07

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 50.91  E-value: 2.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 115 AFAGVPAsddpentPKTIVDVGCGIGGSSRYLAKKY-GAQCTGITLSPV---QAERgNALagAQGLSDQVTLQVADALEQ 190
Cdd:COG4123   31 AFAPVKK-------GGRVLDLGTGTGVIALMLAQRSpGARITGVEIQPEaaeLARR-NVA--LNGLEDRITVIHGDLKEF 100

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 452076209 191 P--FPDGQFDLV------WSMESGEHMPDKRK-------------FVSELARVAAPGGTIIIVTWCHR 237
Cdd:COG4123  101 AaeLPPGSFDLVvsnppyFKAGSGRKSPDEARaiarhedaltledLIRAAARLLKPGGRFALIHPAER 168
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 125-240 4.19e-07

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 49.80  E-value: 4.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 125 PENTPKTIVDVGCGIGGSSRYLAKKY-GAQCTGITLSP--VQAERGNALagAQGLSDqVTLQVADALEQpFPDGQFDLVW 201
Cdd:COG2813   46 PEPLGGRVLDLGCGYGVIGLALAKRNpEARVTLVDVNAraVELARANAA--ANGLEN-VEVLWSDGLSG-VPDGSFDLIL 121

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 452076209 202 S---MESGEHMPDK--RKFVSELARVAAPGGTIIIVTwcHRNLD 240
Cdd:COG2813  122 SnppFHAGRAVDKEvaHALIADAARHLRPGGELWLVA--NRHLP 163
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
128-236 4.95e-06

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 47.05  E-value: 4.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209  128 TPKTIVDVGCGIGGSSRYLAKKYGAQCT--GITLSPVQAERGNALAGAQGLSdQVTLQVADALEQPFPDGQFDLVWSMES 205
Cdd:pfam01209  42 RGNKFLDVAGGTGDWTFGLSDSAGSSGKvvGLDINENMLKEGEKKAKEEGKY-NIEFLQGNAEELPFEDDSFDIVTISFG 120

                          90       100       110
                  ....*....|....*....|....*....|.
gi 452076209  206 GEHMPDKRKFVSELARVAAPGGTIIIVTWCH 236
Cdd:pfam01209 121 LRNFPDYLKVLKEAFRVLKPGGRVVCLEFSK 151
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 109-200 1.46e-05

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 45.91  E-value: 1.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 109 MIEEALAFAgvpasddPENTPKTIVDVGCG---IGGSsryLAKKY-GAQCTGITLSPvqaergNALAGAQ------GLSD 178
Cdd:COG2890  100 LVELALALL-------PAGAPPRVLDLGTGsgaIALA---LAKERpDARVTAVDISP------DALAVARrnaerlGLED 163

                         90       100
                 ....*....|....*....|..
gi 452076209 179 QVTLQVADALEQPFPDGQFDLV 200
Cdd:COG2890  164 RVRFLQGDLFEPLPGDGRFDLI 185
rrmA PRK11088
23S rRNA methyltransferase A; Provisional
 128-233 2.03e-05

23S rRNA methyltransferase A; Provisional


Pssm-ID: 236841 [Multi-domain]  Cd Length: 272  Bit Score: 45.67  E-value: 2.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 128 TPKTIVDVGCGIGG-SSRY---LAKKYGAQCTGITLSPVqaergnALAGAQGLSDQVTLQVADALEQPFPDGQFDLVWSM 203
Cdd:PRK11088  85 KATALLDIGCGEGYyTHALadaLPEITTMQLFGLDISKV------AIKYAAKRYPQVTFCVASSHRLPFADQSLDAIIRI 158

                         90       100       110
                 ....*....|....*....|....*....|
gi 452076209 204 esgeHMPDKrkfVSELARVAAPGGTIIIVT 233
Cdd:PRK11088 159 ----YAPCK---AEELARVVKPGGIVITVT 181
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 102-200 2.08e-05

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 45.94  E-value: 2.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 102 HRRAQIRMIEEALAFAGvpasddpENTPKTIVDVGCGIGGSSRYLAKKyGAQCTGITLSPVQAERGNALAGAQGLsDQVT 181
Cdd:COG2265  214 NPEQAEALYAAALEWLD-------LTGGERVLDLYCGVGTFALPLARR-AKKVIGVEIVPEAVEDARENARLNGL-KNVE 284

                         90       100
                 ....*....|....*....|..
gi 452076209 182 LQVADA---LEQPFPDGQFDLV 200
Cdd:COG2265  285 FVAGDLeevLPELLWGGRPDVV 306
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 109-231 2.39e-05

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 45.15  E-value: 2.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 109 MIEEALAFAgvpasddPENTPKTIVDVGCG---IGGSsryLAKKY-GAQCTGITLSPV---QAERgNAlagAQGLSDQVT 181
Cdd:PRK09328  96 LVEWALEAL-------LLKEPLRVLDLGTGsgaIALA---LAKERpDAEVTAVDISPEalaVARR-NA---KHGLGARVE 161

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 452076209 182 LQVADALEqPFPDGQFDLV-----------WSMESGE---HMPDK------------RKFVSELARVAAPGGTIII 231
Cdd:PRK09328 162 FLQGDWFE-PLPGGRFDLIvsnppyipeadIHLLQPEvrdHEPHLalfggedgldfyRRIIEQAPRYLKPGGWLLL 236
PLN02396 PLN02396
hexaprenyldihydroxybenzoate methyltransferase
 116-233 1.05e-04

hexaprenyldihydroxybenzoate methyltransferase


Pssm-ID: 178018 [Multi-domain]  Cd Length: 322  Bit Score: 43.57  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 116 FAGVPASDDPENTPKtIVDVGCGIGGSSRYLAKkYGAQCTGITlspvQAERGNALAGAQGLSDQVTLQV---ADALEQPF 192
Cdd:PLN02396 120 FSKDPSSAKPFEGLK-FIDIGCGGGLLSEPLAR-MGATVTGVD----AVDKNVKIARLHADMDPVTSTIeylCTTAEKLA 193

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 452076209 193 PDG-QFDLVWSMESGEHMPDKRKFVSELARVAAPGGTIIIVT 233
Cdd:PLN02396 194 DEGrKFDAVLSLEVIEHVANPAEFCKSLSALTIPNGATVLST 235
Methyltransf_20 pfam12147
Putative methyltransferase; This domain is found in bacteria and eukaryotes and is ...
 107-230 2.96e-04

Putative methyltransferase; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The family shows homology to methyltransferases.


Pssm-ID: 432362  Cd Length: 309  Bit Score: 41.99  E-value: 2.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209  107 IRM----IEEAL--AFAGVPASDDPENtpktIVDVGCGIGgssRYL---AKKYGAQCTGITL---SPVQAERGNALAGAQ 174
Cdd:pfam12147 110 IRQrkvhLEELLqqAIARLRAKGQPVR----ILDIAAGHG---RYVleaLAKLPQRPESILLrdySPLNVEQGNALIAAK 182

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 452076209  175 GLSDQVTLQVADALE-------QPFPDgqfdlvWSMESG--EHMPDK---RKFVSELARVAAPGGTII 230
Cdd:pfam12147 183 GLEDIARFEQGDAFDpdslaalTPQPT------LAIVSGlyELFPDNdlvRRSLAGLAAAVEPGGYLI 244
PLN02490 PLN02490
MPBQ/MSBQ methyltransferase
 109-227 7.81e-04

MPBQ/MSBQ methyltransferase


Pssm-ID: 215270 [Multi-domain]  Cd Length: 340  Bit Score: 41.03  E-value: 7.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 109 MIEEALAfagvPASDDPENTpkTIVDVGCGIGGSSRYLAKKYGAQ-CTGITLSPVQAERGNALAGAQGlsdqVTLQVADA 187
Cdd:PLN02490 100 MRDDALE----PADLSDRNL--KVVDVGGGTGFTTLGIVKHVDAKnVTILDQSPHQLAKAKQKEPLKE----CKIIEGDA 169

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 452076209 188 LEQPFPDGQFDLVWSMESGEHMPDKRKFVSELARVAAPGG 227
Cdd:PLN02490 170 EDLPFPTDYADRYVSAGSIEYWPDPQRGIKEAYRVLKIGG 209
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
85-200 3.11e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 38.48  E-value: 3.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209  85 HMHHgfydsseaaSM-ADHRRaqIRMIEEALAFAGVPAsddpentpKTIVDVGCGIGGSSrYLAKKYGA-QCTGITLSPV 162
Cdd:COG4076   10 RWHH---------PMlNDVER--NDAFKAAIERVVKPG--------DVVLDIGTGSGLLS-MLAARAGAkKVYAVEVNPD 69

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 452076209 163 QAERGNALAGAQGLSDQVTLQVADALEQPFPDgQFDLV 200
Cdd:COG4076   70 IAAVARRIIAANGLSDRITVINADATDLDLPE-KADVI 106
Methyltransf_32 pfam13679
Methyltransferase domain; This family appears to be a methyltransferase domain.
 110-197 5.22e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 379330 [Multi-domain]  Cd Length: 138  Bit Score: 36.78  E-value: 5.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209  110 IEEALAF-AGVPASDDPENTPKTIVDVGCGIGgssrYLA-----KKYGAQCTGITLSPVQAERGNALAGAQGLSDQ---V 180
Cdd:pfam13679   6 VEHLAEFiAPLLKELLDENGPITIVDHGAGKG----YLGfilyyLKYGVRVYGIDTRAELVEKANALAQKLGFNKRmsfL 81

                          90
                  ....*....|....*..
gi 452076209  181 TLQVADALEQPFPDGQF 197
Cdd:pfam13679  82 EGTIAGSTPVELPDRVD 98
PRK14103 PRK14103
trans-aconitate 2-methyltransferase; Provisional
 100-229 7.31e-03

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 184509  Cd Length: 255  Bit Score: 37.75  E-value: 7.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452076209 100 ADHRRaqiRMIEEALAFAGVPasddpenTPKTIVDVGCGIGGSSRYLAKKY-GAQCTGITLSPVQAERgnalAGAQGLsD 178
Cdd:PRK14103  11 ADHRG---RPFYDLLARVGAE-------RARRVVDLGCGPGNLTRYLARRWpGAVIEALDSSPEMVAA----ARERGV-D 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 452076209 179 QVTLQVADAleQPFPDgqFDLV-------WSMESGEHMPdkrKFVSELarvaAPGGTI 229
Cdd:PRK14103  76 ARTGDVRDW--KPKPD--TDVVvsnaalqWVPEHADLLV---RWVDEL----APGSWI 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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