NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|461180628|gb|AGH15851|]
View 

xylose reductase, partial [Scheffersomyces lignosus]

Protein Classification

aldo-keto reductase family protein( domain architecture ID 305)

aldo-keto reductase family protein may be an NAD(P)(H) oxidoreductase that reduces aldehydes and ketones to primary and secondary alcohols

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AKR_SF super family cl00470
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 1-191 1.10e-140

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


The actual alignment was detected with superfamily member cd19113:

Pssm-ID: 444925 [Multi-domain]  Cd Length: 310  Bit Score: 394.12  E-value: 1.10e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAADQVYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAIDEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVD 80
Cdd:cd19113   22 DNATAADQIYQAIKAGYRLFDGAEDYGNEKEVGEGVNRAIDEGLVKREELFLTSKLWNNFHDPKNVETALNKTLSDLKLD 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  81 YIDLFYIHFPIAFKFVPIEEKYPPAFYCGDGDNFHYEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIK 160
Cdd:cd19113  102 YVDLFLIHFPIAFKFVPIEEKYPPGFYCGDGDNFVYEDVPILDTWKALEKLVDAGKIKSIGVSNFPGALILDLLRGATIK 181

                        170       180       190
                 ....*....|....*....|....*....|.
gi 461180628 161 PAVLQVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19113  182 PAVLQIEHHPYLQQPKLIEYAQKAGITITAY 212
 
Name Accession Description Interval E-value
AKR_AKR2B1-10 cd19113
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ...
 1-191 1.10e-140

AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.


Pssm-ID: 381339 [Multi-domain]  Cd Length: 310  Bit Score: 394.12  E-value: 1.10e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAADQVYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAIDEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVD 80
Cdd:cd19113   22 DNATAADQIYQAIKAGYRLFDGAEDYGNEKEVGEGVNRAIDEGLVKREELFLTSKLWNNFHDPKNVETALNKTLSDLKLD 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  81 YIDLFYIHFPIAFKFVPIEEKYPPAFYCGDGDNFHYEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIK 160
Cdd:cd19113  102 YVDLFLIHFPIAFKFVPIEEKYPPGFYCGDGDNFVYEDVPILDTWKALEKLVDAGKIKSIGVSNFPGALILDLLRGATIK 181

                        170       180       190
                 ....*....|....*....|....*....|.
gi 461180628 161 PAVLQVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19113  182 PAVLQIEHHPYLQQPKLIEYAQKAGITITAY 212
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 1-191 5.50e-70

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 212.99  E-value: 5.50e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAAdqVYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAideGlVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVD 80
Cdd:COG0656   18 EEAAAA--VRTALEAGYRHIDTAAMYGNEEGVGEAIAAS---G-VPREELFVTTKVWNDNHGYDDTLAAFEESLERLGLD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  81 YIDLFYIHFPIafkfvpieekyppafycgdgdnfhyeDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIK 160
Cdd:COG0656   92 YLDLYLIHWPG--------------------------PGPYVETWRALEELYEEGLIRAIGVSNFDPEHLEELLAETGVK 145

                        170       180       190
                 ....*....|....*....|....*....|.
gi 461180628 161 PAVLQVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:COG0656  146 PAVNQVELHPYLQQRELLAFCREHGIVVEAY 176
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 13-191 3.59e-38

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 132.82  E-value: 3.59e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   13 IKAGYRLFDGAEDYG---NEKEIGdgvkRAIDEGLVTREEIFLTSKLWNN------YHDPKNVEKALDKTLADLKVDYID 83
Cdd:pfam00248  28 LEAGINFIDTAEVYGdgkSEELLG----EALKDYPVKRDKVVIATKVPDGdgpwpsGGSKENIRKSLEESLKRLGTDYID 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   84 LFYIHFPiafkfvpieekyppafycgdgdnfhYEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPAV 163
Cdd:pfam00248 104 LYYLHWP-------------------------DPDTPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKALTKGKIPIVA 158

                         170       180       190
                  ....*....|....*....|....*....|
gi 461180628  164 LQVEHHPY--LQQPKLIEFAQKAGLIVTGY 191
Cdd:pfam00248 159 VQVEYNLLrrRQEEELLEYCKKNGIPLIAY 188
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
5-177 3.49e-33

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 119.41  E-value: 3.49e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   5 AADQVYQGIKAGYRLFDGAEDYGNEKeigdGVKRAIDEGLVTREEIFLTSKLWNNyhDPKNVEKALDKTLADLKVDYIDL 84
Cdd:PRK11565  30 VITAIHKALEVGYRSIDTAAIYKNEE----GVGKALKEASVAREELFITTKLWND--DHKRPREALEESLKKLQLDYVDL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  85 FYIHFPiafkfVPIEEKYppafycgdgdnfhyedvpiLETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPAVL 164
Cdd:PRK11565 104 YLMHWP-----VPAIDHY-------------------VEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVIN 159

                        170
                 ....*....|...
gi 461180628 165 QVEHHPYLQQPKL 177
Cdd:PRK11565 160 QIELHPLMQQRQL 172
 
Name Accession Description Interval E-value
AKR_AKR2B1-10 cd19113
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ...
 1-191 1.10e-140

AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.


Pssm-ID: 381339 [Multi-domain]  Cd Length: 310  Bit Score: 394.12  E-value: 1.10e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAADQVYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAIDEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVD 80
Cdd:cd19113   22 DNATAADQIYQAIKAGYRLFDGAEDYGNEKEVGEGVNRAIDEGLVKREELFLTSKLWNNFHDPKNVETALNKTLSDLKLD 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  81 YIDLFYIHFPIAFKFVPIEEKYPPAFYCGDGDNFHYEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIK 160
Cdd:cd19113  102 YVDLFLIHFPIAFKFVPIEEKYPPGFYCGDGDNFVYEDVPILDTWKALEKLVDAGKIKSIGVSNFPGALILDLLRGATIK 181

                        170       180       190
                 ....*....|....*....|....*....|.
gi 461180628 161 PAVLQVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19113  182 PAVLQIEHHPYLQQPKLIEYAQKAGITITAY 212
AKR_AKR2D1 cd19115
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ...
 6-191 1.97e-98

AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.


Pssm-ID: 381341 [Multi-domain]  Cd Length: 311  Bit Score: 287.39  E-value: 1.97e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   6 ADQVYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAIDEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYIDLF 85
Cdd:cd19115   29 ADQVYNAIKAGYRLFDGACDYGNEVEAGQGVARAIKEGIVKREDLFIVSKLWNTFHDGERVEPICRKQLADWGIDYFDLF 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  86 YIHFPIAFKFVPIEEKYPPAFYcGDGDNFHYEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPAVLQ 165
Cdd:cd19115  109 LIHFPIALKYVDPAVRYPPGWF-YDGKKVEFSNAPIQETWTAMEKLVDKGLARSIGVSNFSAQLLMDLLRYARIRPATLQ 187

                        170       180
                 ....*....|....*....|....*.
gi 461180628 166 VEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19115  188 IEHHPYLTQPRLVKYAQKEGIAVTAY 213
AKR_AKR2C1 cd19114
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ...
 9-191 6.27e-79

AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.


Pssm-ID: 381340 [Multi-domain]  Cd Length: 302  Bit Score: 237.46  E-value: 6.27e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   9 VYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAIDEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYIDLFYIH 88
Cdd:cd19114   23 IYNAIKVGYRLIDGALLYGNEAEVGRGIRKAIQEGLVKREDLFIVTKLWNNFHGKDHVREAFDRQLKDYGLDYIDLYLIH 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  89 FPIAFKFVPIEEKYPPAFYCGDGDNFHYEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPAVLQVEH 168
Cdd:cd19114  103 FPIPAAYVDPAENYPFLWKDKELKKFPLEQSPMQECWREMEKLVDAGLVRNIGIANFNVQLILDLLTYAKIKPAVLQIEH 182

                        170       180
                 ....*....|....*....|...
gi 461180628 169 HPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19114  183 HPYLQQKRLIDWAKKQGIQITAY 205
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
 5-191 1.79e-78

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 234.30  E-value: 1.79e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   5 AADQVYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAIdeglVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYIDL 84
Cdd:cd19071   16 TAEAVLAALEAGYRHIDTAAAYGNEAEVGEAIRESG----VPREELFITTKLWPTDHGYERVREALEESLKDLGLDYLDL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  85 FYIHFPIAFKFVPIeekyppafycgdgdnfhyeDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPAVL 164
Cdd:cd19071   92 YLIHWPVPGKEGGS-------------------KEARLETWRALEELVDEGLVRSIGVSNFNVEHLEELLAAARIKPAVN 152

                        170       180
                 ....*....|....*....|....*..
gi 461180628 165 QVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19071  153 QIELHPYLQQKELVEFCKEHGIVVQAY 179
AKR_AKR4C1-15 cd19125
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ...
 1-191 3.44e-73

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.


Pssm-ID: 381351 [Multi-domain]  Cd Length: 287  Bit Score: 222.22  E-value: 3.44e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAADQVYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAIDEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVD 80
Cdd:cd19125   22 DPGVVGNAVKTAIKEGYRHIDCAAIYGNEKEIGKALKKLFEDGVVKREDLFITSKLWCTDHAPEDVPPALEKTLKDLQLD 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  81 YIDLFYIHFPIAFK---FVPIEEKYPPafycgdgdnfhyedVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGA 157
Cdd:cd19125  102 YLDLYLIHWPVRLKkgaHMPEPEEVLP--------------PDIPSTWKAMEKLVDSGKVRAIGVSNFSVKKLEDLLAVA 167

                        170       180       190
                 ....*....|....*....|....*....|....
gi 461180628 158 TIKPAVLQVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19125  168 RVPPAVNQVECHPGWQQDKLHEFCKSKGIHLSAY 201
AKR_AKR2E1-5 cd19116
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ...
 9-191 1.30e-71

AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.


Pssm-ID: 381342 [Multi-domain]  Cd Length: 292  Bit Score: 218.31  E-value: 1.30e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   9 VYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAIDEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYIDLFYIH 88
Cdd:cd19116   31 VKHAIEAGYRHIDTAYLYGNEAEVGEAIREKIAEGVVKREDLFITTKLWNSYHEREQVEPALRESLKRLGLDYVDLYLIH 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  89 FPIAFKFVPIEEkyppafycgDGDNFHYEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPAVLQVEH 168
Cdd:cd19116  111 WPVAFKENNDSE---------SNGDGSLSDIDYLETWRGMEDLVKLGLTRSIGVSNFNSEQINRLLSNCNIKPAVNQIEV 181

                        170       180
                 ....*....|....*....|...
gi 461180628 169 HPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19116  182 HPTLTQEKLVAYCQSNGIVVMAY 204
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 1-191 5.50e-70

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 212.99  E-value: 5.50e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAAdqVYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAideGlVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVD 80
Cdd:COG0656   18 EEAAAA--VRTALEAGYRHIDTAAMYGNEEGVGEAIAAS---G-VPREELFVTTKVWNDNHGYDDTLAAFEESLERLGLD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  81 YIDLFYIHFPIafkfvpieekyppafycgdgdnfhyeDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIK 160
Cdd:COG0656   92 YLDLYLIHWPG--------------------------PGPYVETWRALEELYEEGLIRAIGVSNFDPEHLEELLAETGVK 145

                        170       180       190
                 ....*....|....*....|....*....|.
gi 461180628 161 PAVLQVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:COG0656  146 PAVNQVELHPYLQQRELLAFCREHGIVVEAY 176
AKR_AKR3G1 cd19123
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ...
 9-191 5.79e-70

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.


Pssm-ID: 381349 [Multi-domain]  Cd Length: 297  Bit Score: 214.58  E-value: 5.79e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   9 VYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAIDEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYIDLFYIH 88
Cdd:cd19123   31 VKQALEAGYRHIDCAAIYGNEAEIGAALAEVFKEGKVKREDLWITSKLWNNSHAPEDVLPALEKTLADLQLDYLDLYLMH 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  89 FPIAFKfvpieekyPPAFYCGDGDNF-HYEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPAVLQVE 167
Cdd:cd19123  111 WPVALK--------KGVGFPESGEDLlSLSPIPLEDTWRAMEELVDKGLCRHIGVSNFSVKKLEDLLATARIKPAVNQVE 182

                        170       180
                 ....*....|....*....|....
gi 461180628 168 HHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19123  183 LHPYLQQPELLAFCRDNGIHLTAY 206
AKR_AKR1A1-4 cd19106
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ...
 13-191 4.91e-69

AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.


Pssm-ID: 381332 [Multi-domain]  Cd Length: 305  Bit Score: 212.25  E-value: 4.91e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  13 IKAGYRLFDGAEDYGNEKEIGDGVKRAIDEGL-VTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYIDLFYIHFPI 91
Cdd:cd19106   30 LDAGYRHIDCAAVYGNEQEVGEALKEKVGPGKaVPREDLFVTSKLWNTKHHPEDVEPALRKTLKDLQLDYLDLYLIHWPY 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  92 AFKfvPIEEKYPPafycGDGDNFHYEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPAVLQVEHHPY 171
Cdd:cd19106  110 AFE--RGDNPFPK----NPDGTIRYDSTHYKETWKAMEKLVDKGLVKAIGLSNFNSRQIDDILSVARIKPAVLQVECHPY 183

                        170       180
                 ....*....|....*....|
gi 461180628 172 LQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19106  184 LAQNELIAHCKARGLVVTAY 203
AKR_AKR3B1-3 cd19118
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ...
 6-191 7.92e-65

AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.


Pssm-ID: 381344 [Multi-domain]  Cd Length: 283  Bit Score: 200.71  E-value: 7.92e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   6 ADQVYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAIDE-GLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYIDL 84
Cdd:cd19118   23 GAAVKIALKAGYRHLDLAKVYQNQHEVGQALKELLKEePGVKREDLFITSKLWNNSHRPEYVEPALDDTLKELGLDYLDL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  85 FYIHFPIAFKFVPIEEKYPPAfyCGDGDNFHYED-VPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPAV 163
Cdd:cd19118  103 YLIHWPVAFKPTGDLNPLTAV--PTNGGEVDLDLsVSLVDTWKAMVELKKTGKVKSIGVSNFSIDHLQAIIEETGVVPAV 180

                        170       180
                 ....*....|....*....|....*...
gi 461180628 164 LQVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19118  181 NQIEAHPLLLQDELVDYCKSKNIHITAY 208
AKR_AKR1G1_CeAKR cd19154
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ...
 13-191 1.34e-57

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381380 [Multi-domain]  Cd Length: 303  Bit Score: 183.00  E-value: 1.34e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  13 IKAGYRLFDGAEDYGNEKEIGDGVKRAIDEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYIDLFYIHFPIA 92
Cdd:cd19154   35 LKAGYRLIDTAFLYQNEEAIGEALAELLEEGVVKREDLFITTKLWTHEHAPEDVEEALRESLKKLQLEYVDLYLIHAPAA 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  93 FKfvPIEEKYPPAfycgDGDNFHYEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPAVLQVEHHPYL 172
Cdd:cd19154  115 FK--DDEGESGTM----ENGMSIHDAVDVEDVWRGMEKVYDEGLTKAIGVSNFNNDQIQRILDNARVKPHNNQVECHLYF 188

                        170
                 ....*....|....*....
gi 461180628 173 QQPKLIEFAQKAGLIVTGY 191
Cdd:cd19154  189 PQKELVEFCKKHNISVTSY 207
AKR_GlAR-like cd19128
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ...
 9-191 4.52e-57

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.


Pssm-ID: 381354 [Multi-domain]  Cd Length: 277  Bit Score: 180.80  E-value: 4.52e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   9 VYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAIDEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYIDLFYIH 88
Cdd:cd19128   20 VKNAIKAGYRHIDCAYYYGNEAFIGIAFSEIFKDGGVKREDLFITSKLWPTMHQPENVKEQLLITLQDLQLEYLDLFLIH 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  89 FPIAfkFVPIEEKYPPAFYCGDGDnfhyEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPAVLQVEH 168
Cdd:cd19128  100 WPLA--FDMDTDGDPRDDNQIQSL----SKKPLEDTWRAMEQCVDEKLTKNIGVSNYSTKLLTDLLNYCKIKPFMNQIEC 173

                        170       180
                 ....*....|....*....|...
gi 461180628 169 HPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19128  174 HPYFQNDKLIKFCIENNIHVTAY 196
AKR_AKR2A1-2 cd19112
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ...
 7-191 1.09e-55

AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.


Pssm-ID: 381338 [Multi-domain]  Cd Length: 308  Bit Score: 178.45  E-value: 1.09e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   7 DQVYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAIDEGLVTREEIFLTSKLWNNYHDpkNVEKALDKTLADLKVDYIDLFY 86
Cdd:cd19112   28 ELILNAIKIGYRHFDCAADYKNEKEVGEALAEAFKTGLVKREDLFITTKLWNSDHG--HVIEACKDSLKKLQLDYLDLYL 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  87 IHFPIAFKFVPIEEkyPPAFYCGDGDNFHYEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPAVLQV 166
Cdd:cd19112  106 VHFPVATKHTGVGT--TGSALGEDGVLDIDVTISLETTWHAMEKLVSAGLVRSIGISNYDIFLTRDCLAYSKIKPAVNQI 183

                        170       180
                 ....*....|....*....|....*
gi 461180628 167 EHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19112  184 ETHPYFQRDSLVKFCQKHGISVTAH 208
AKR_AKR3D1 cd19121
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ...
 9-191 4.46e-55

AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.


Pssm-ID: 381347 [Multi-domain]  Cd Length: 279  Bit Score: 175.80  E-value: 4.46e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   9 VYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAIDEGlVTREEIFLTSKLWNNYHDpkNVEKALDKTLADLKVDYIDLFYIH 88
Cdd:cd19121   31 VAHALKIGYRHIDGALCYQNEDEVGEGIKEAIAGG-VKREDLFVTTKLWSTYHR--RVELCLDRSLKSLGLDYVDLYLVH 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  89 FPIAFKFVPIEEKYPPAfycGDGDNFHYEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPAVLQVEH 168
Cdd:cd19121  108 WPVLLNPNGNHDLFPTL---PDGSRDLDWDWNHVDTWKQMEKVLKTGKTKAIGVSNYSIPYLEELLKHATVVPAVNQVEN 184

                        170       180
                 ....*....|....*....|...
gi 461180628 169 HPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19121  185 HPYLPQQELVDFCKEKGILIEAY 207
AKR_BaDH-like cd19129
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ...
 1-191 3.75e-54

Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.


Pssm-ID: 381355 [Multi-domain]  Cd Length: 295  Bit Score: 173.80  E-value: 3.75e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAADQVYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAIDEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVD 80
Cdd:cd19129   17 DPSATRNAVKAALEAGFRHFDCAERYRNEAEVGEAMQEVFKAGKIRREDLFVTTKLWNTNHRPERVKPAFEASLKRLQLD 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  81 YIDLFYIHFPIAFKfvPIEEKYPPAfycGDGDNFHYEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIK 160
Cdd:cd19129   97 YLDLYLIHTPFAFQ--PGDEQDPRD---ANGNVIYDDGVTLLDTWRAMERLVDEGRCKAIGLSDVSLEKLREIFEAARIK 171

                        170       180       190
                 ....*....|....*....|....*....|.
gi 461180628 161 PAVLQVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19129  172 PAVVQVESHPYLPEWELLDFCKNHGIVLQAF 202
AKR_AKR3C2-3 cd19120
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ...
 5-191 4.30e-54

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.


Pssm-ID: 381346 [Multi-domain]  Cd Length: 269  Bit Score: 172.80  E-value: 4.30e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   5 AADQVYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAidegLVTREEIFLTSKLWNNyhdPKNVEKALDKTLADLKVDYIDL 84
Cdd:cd19120   27 LVDSVKLALKAGFRHIDTAEMYGNEKEVGEALKES----GVPREDLFITTKVSPG---IKDPREALRKSLAKLGVDYVDL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  85 FYIHFPiafkfvpieekyppaFYCGDGDNfhyedvPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPAVL 164
Cdd:cd19120  100 YLIHSP---------------FFAKEGGP------TLAEAWAELEALKDAGLVRSIGVSNFRIEDLEELLDTAKIKPAVN 158

                        170       180
                 ....*....|....*....|....*....
gi 461180628 165 QVEHHPYL--QQPKLIEFAQKAGLIVTGY 191
Cdd:cd19120  159 QIEFHPYLypQQPALLEYCREHGIVVSAY 187
AKR_DrGR-like cd19136
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ...
 1-191 9.27e-54

Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).


Pssm-ID: 381362 [Multi-domain]  Cd Length: 262  Bit Score: 172.05  E-value: 9.27e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAADQVYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAIDEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVD 80
Cdd:cd19136   13 GEEEVRQAVDAALKAGYRLIDTASVYRNEADIGKALRDLLPKYGLSREDIFITSKLAPKDQGYEKARAACLGSLERLGTD 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  81 YIDLFYIHFPIAFKFVPieekyppafycGDGDNFHYEdvpiLETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIK 160
Cdd:cd19136   93 YLDLYLIHWPGVQGLKP-----------SDPRNAELR----RESWRALEDLYKEGKLRAIGVSNYTVRHLEELLKYCEVP 157

                        170       180       190
                 ....*....|....*....|....*....|.
gi 461180628 161 PAVLQVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19136  158 PAVNQVEFHPHLVQKELLKFCKDHGIHLQAY 188
AKR_AKR4A_4B cd19124
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ...
 9-191 2.16e-53

AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.


Pssm-ID: 381350 [Multi-domain]  Cd Length: 281  Bit Score: 171.68  E-value: 2.16e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   9 VYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAIDEGLV-TREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYIDLFYI 87
Cdd:cd19124   26 VLEAIEVGYRHFDTAAAYGTEEALGEALAEALRLGLVkSRDELFVTSKLWCSDAHPDLVLPALKKSLRNLQLEYVDLYLI 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  88 HFPIAFK----FVPIEEKYPPAFycgdgdnfhyeDVPilETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPAV 163
Cdd:cd19124  106 HWPVSLKpgkfSFPIEEEDFLPF-----------DIK--GVWEAMEECQRLGLTKAIGVSNFSCKKLQELLSFATIPPAV 172

                        170       180
                 ....*....|....*....|....*...
gi 461180628 164 LQVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19124  173 NQVEMNPAWQQKKLREFCKANGIHVTAY 200
AKR_AKR1B1-19 cd19107
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ...
 9-191 8.29e-53

AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.


Pssm-ID: 381333 [Multi-domain]  Cd Length: 307  Bit Score: 171.06  E-value: 8.29e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   9 VYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAIDEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYIDLFYIH 88
Cdd:cd19107   23 VKVAIDAGYRHIDCAYVYQNENEVGEAIQEKIKEQVVKREDLFIVSKLWCTFHEKGLVKGACQKTLSDLKLDYLDLYLIH 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  89 FPIAFK----FVPIEEKyppafycgdgDNFHYEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLR--GATIKPA 162
Cdd:cd19107  103 WPTGFKpgkeLFPLDES----------GNVIPSDTTFLDTWEAMEELVDEGLVKAIGVSNFNHLQIERILNkpGLKYKPA 172

                        170       180
                 ....*....|....*....|....*....
gi 461180628 163 VLQVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19107  173 VNQIECHPYLTQEKLIQYCQSKGIVVTAY 201
AKR_AKR3C1 cd19119
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ...
 1-191 9.18e-51

Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).


Pssm-ID: 381345 [Multi-domain]  Cd Length: 294  Bit Score: 165.36  E-value: 9.18e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAADQVYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAIDEGLVTREEIFLTSKLWNNYHDpkNVEKALDKTLADLKVD 80
Cdd:cd19119   25 DRAEVKEAVEAAIKEGYRHIDTAYAYETEDFVGEAIKRAIDDGSIKREELFITTKVWPTFYD--EVERSLDESLKALGLD 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  81 YIDLFYIHFPIAFKfvPIEEKYPPAFYC--GDGDNFHYEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGAT 158
Cdd:cd19119  103 YVDLLLVHWPVCFE--KDSDDSGKPFTPvnDDGKTRYAASGDHITTYKQLEKIYLDGRAKAIGVSNYSIVYLERLIKECK 180

                        170       180       190
                 ....*....|....*....|....*....|...
gi 461180628 159 IKPAVLQVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19119  181 VVPAVNQVELHPHLPQMDLRDFCFKHGILVTAY 213
AKR_AKR1D1-3 cd19109
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ...
 5-191 1.18e-50

AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.


Pssm-ID: 381335 [Multi-domain]  Cd Length: 308  Bit Score: 165.36  E-value: 1.18e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   5 AADQVYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAIDEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYIDL 84
Cdd:cd19109   23 CAEAVKVAIDTGYRHIDGAYIYQNEHEVGQAIREKIAEGKVKREDIFYCGKLWNTCHPPELVRPTLERTLKVLQLDYVDL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  85 FYIHFPIAFKfvPIEEKYPPafycGDGDNFHYEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLR--GATIKPA 162
Cdd:cd19109  103 YIIEMPMAFK--PGDEIYPR----DENGKWLYHKTNLCATWEALEACKDAGLVKSIGVSNFNRRQLELILNkpGLKHKPV 176

                        170       180
                 ....*....|....*....|....*....
gi 461180628 163 VLQVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19109  177 SNQVECHPYFTQPKLLEFCQQHDIVIVAY 205
AKR_AKR3F2_3 cd19073
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ...
 2-191 1.72e-49

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381299 [Multi-domain]  Cd Length: 243  Bit Score: 160.51  E-value: 1.72e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   2 TAIAADQVYQGIKAGYRLFDGAEDYGNEKEIGDGVKraidEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDY 81
Cdd:cd19073   13 GDDCANAVKEALELGYRHIDTAEIYNNEAEVGEAIA----ESGVPREDLFITTKVWRDHLRPEDLKKSVDRSLEKLGTDY 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  82 IDLFYIHFPIafkfvpieekyppafycgdgdnfhyEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKP 161
Cdd:cd19073   89 VDLLLIHWPN-------------------------PTVPLEETLGALKELKEAGKVKSIGVSNFTIELLEEALDISPLPI 143

                        170       180       190
                 ....*....|....*....|....*....|
gi 461180628 162 AVLQVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19073  144 AVNQVEFHPFLYQAELLEYCRENDIVITAY 173
AKR_AKR1G1_1I cd19111
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ...
 13-191 3.01e-49

Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381337 [Multi-domain]  Cd Length: 286  Bit Score: 161.13  E-value: 3.01e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  13 IKAGYRLFDGAEDYGNEKEIGDGVKRAIDEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYIDLFYIHFPIA 92
Cdd:cd19111   27 LFVGYRHIDTALSYQNEKAIGEALKWWLKNGKLKREEVFITTKLPPVYLEFKDTEKSLEKSLENLKLPYVDLYLIHHPCG 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  93 FKfvpieekyppafYCGDGDNFHYEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPAVLQVEHHPYL 172
Cdd:cd19111  107 FV------------NKKDKGERELASSDVTSVWRAMEALVSEGKVKSIGLSNFNPRQINKILAYAKVKPSNLQLECHAYL 174

                        170
                 ....*....|....*....
gi 461180628 173 QQPKLIEFAQKAGLIVTGY 191
Cdd:cd19111  175 QQRELRKFCNKKNIVVTAY 193
AKR_AKR3A1-2 cd19117
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ...
 5-191 4.26e-49

AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.


Pssm-ID: 381343 [Multi-domain]  Cd Length: 284  Bit Score: 160.74  E-value: 4.26e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   5 AADQVYQGIKAGYRLFDGAEDYGNEKEIGDGVKraiDEGlVTREEIFLTSKLWNNYHdpKNVEKALDKTLADLKVDYIDL 84
Cdd:cd19117   29 VAKAVEAALKAGYRHIDTAAIYGNEEEVGQGIK---DSG-VPREEIFITTKLWCTWH--RRVEEALDQSLKKLGLDYVDL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  85 FYIHFPiafkfVPIEEKY-PPAFYCGDGDNFHYEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLR--GATIKP 161
Cdd:cd19117  103 YLMHWP-----VPLDPDGnDFLFKKDDGTKDHEPDWDFIKTWELMQKLPATGKVKAIGVSNFSIKNLEKLLAspSAKIVP 177

                        170       180       190
                 ....*....|....*....|....*....|
gi 461180628 162 AVLQVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19117  178 AVNQIELHPLLPQPKLVDFCKSKGIHATAY 207
AKR_AKR1C1-35 cd19108
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ...
 13-191 9.70e-49

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.


Pssm-ID: 381334 [Multi-domain]  Cd Length: 303  Bit Score: 160.09  E-value: 9.70e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  13 IKAGYRLFDGAEDYGNEKEIGDGVKRAIDEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYIDLFYIHFPIA 92
Cdd:cd19108   37 IDAGFRHIDSAYLYQNEEEVGQAIRSKIADGTVKREDIFYTSKLWCTFHRPELVRPALEKSLKKLQLDYVDLYLIHFPVA 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  93 FKfvPIEEKYPPafycgDGD-NFHYEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLR--GATIKPAVLQVEHH 169
Cdd:cd19108  117 LK--PGEELFPK-----DENgKLIFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNkpGLKYKPVCNQVECH 189

                        170       180
                 ....*....|....*....|..
gi 461180628 170 PYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19108  190 PYLNQSKLLDFCKSKDIVLVAY 211
AKR_AKR5C2 cd19131
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ...
 1-191 1.62e-48

Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.


Pssm-ID: 381357 [Multi-domain]  Cd Length: 256  Bit Score: 158.30  E-value: 1.62e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAADQVYQGIKAGYRLFDGAEDYGNEkeigDGVKRAIDEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVD 80
Cdd:cd19131   21 SNDEAASAVREALEVGYRSIDTAAIYGNE----EGVGKAIRASGVPREELFITTKLWNSDQGYDSTLRAFDESLRKLGLD 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  81 YIDLFYIHFPiafkfVPIEEKYppafycgdgdnfhyedvpiLETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIK 160
Cdd:cd19131   97 YVDLYLIHWP-----VPAQDKY-------------------VETWKALIELKKEGRVKSIGVSNFTIEHLQRLIDETGVV 152

                        170       180       190
                 ....*....|....*....|....*....|.
gi 461180628 161 PAVLQVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19131  153 PVVNQIELHPRFQQRELRAFHAKHGIQTESW 183
AKR_AKR5F1 cd19133
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ...
 1-191 2.32e-48

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381359 [Multi-domain]  Cd Length: 255  Bit Score: 157.74  E-value: 2.32e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAADQVYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAIdeglVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVD 80
Cdd:cd19133   21 DPEECERAVLEAIKAGYRLIDTAAAYGNEEAVGRAIKKSG----IPREELFITTKLWIQDAGYEKAKKAFERSLKRLGLD 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  81 YIDLFYIHFPiafkfvpieekyppafycgdgdnfhYEDVPilETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIK 160
Cdd:cd19133   97 YLDLYLIHQP-------------------------FGDVY--GAWRAMEELYKEGKIRAIGVSNFYPDRLVDLILHNEVK 149

                        170       180       190
                 ....*....|....*....|....*....|.
gi 461180628 161 PAVLQVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19133  150 PAVNQIETHPFNQQIEAVEFLKKYGVQIEAW 180
AKR_AKR5G1-3 cd19157
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ...
 1-186 1.88e-47

AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381383 [Multi-domain]  Cd Length: 265  Bit Score: 156.01  E-value: 1.88e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAADQVYQGIKAGYRLFDGAEDYGNEkeigDGVKRAIDEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVD 80
Cdd:cd19157   22 EGSEVVNAVKTALKNGYRSIDTAAIYGNE----EGVGKGIKESGIPREELFITSKVWNADQGYDSTLKAFEASLERLGLD 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  81 YIDLFYIHFPIAFKFVpieekyppafycgdgdnfhyedvpilETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIK 160
Cdd:cd19157   98 YLDLYLIHWPVKGKYK--------------------------ETWKALEKLYKDGRVRAIGVSNFQVHHLEDLLADAEIV 151

                        170       180
                 ....*....|....*....|....*.
gi 461180628 161 PAVLQVEHHPYLQQPKLIEFAQKAGL 186
Cdd:cd19157  152 PMVNQVEFHPRLTQKELRDYCKKQGI 177
AKR_AKR1E1-2 cd19110
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ...
 7-191 1.16e-46

AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.


Pssm-ID: 381336 [Multi-domain]  Cd Length: 301  Bit Score: 155.12  E-value: 1.16e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   7 DQVYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAIDEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYIDLFY 86
Cdd:cd19110   21 EAVKVAIDAGYRHFDCAYLYHNESEVGAGIREKIKEGVVRREDLFIVSKLWCTCHKKSLVKTACTRSLKALKLNYLDLYL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  87 IHFPIAFKfvPIEEKYPpafyCGDGDNFHYEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLR--GATIKPAVL 164
Cdd:cd19110  101 IHWPMGFK--PGEPDLP----LDRSGMVIPSDTDFLDTWEAMEDLVIEGLVKNIGVSNFNHEQLERLLNkpGLRVKPVTN 174

                        170       180
                 ....*....|....*....|....*..
gi 461180628 165 QVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19110  175 QIECHPYLTQKKLISFCQSRNVSVTAY 201
AKR_AKR1I_CgAKR1 cd19155
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ...
 13-191 2.09e-45

Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381381 [Multi-domain]  Cd Length: 307  Bit Score: 151.91  E-value: 2.09e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  13 IKAGYRLFDGAEDYGNEKEIGDGVKRAIDEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYIDLFYIHFPIA 92
Cdd:cd19155   35 LEAGYRHIDTAYVYRNEAAIGNVLKKWIDSGKVKREELFIVTKLPPGGNRREKVEKFLLKSLEKLQLDYVDLYLIHFPVG 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  93 FKfvpieekyppafYCGDGDNFHYED--------VPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPAVL 164
Cdd:cd19155  115 SL------------SKEDDSGKLDPTgehkqdytTDLLDIWKAMEAQVDQGLTRSIGLSNFNREQMARILKNARIKPANL 182

                        170       180
                 ....*....|....*....|....*..
gi 461180628 165 QVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19155  183 QVELHVYLQQKDLVDFCSTHSITVTAY 209
AKR_AKR5A_5G cd19126
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ...
 1-191 1.02e-44

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381352 [Multi-domain]  Cd Length: 254  Bit Score: 148.35  E-value: 1.02e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAAdqVYQGIKAGYRLFDGAEDYGNEKeigdGVKRAIDEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVD 80
Cdd:cd19126   23 DETERA--VQTALENGYRSIDTAAIYKNEE----GVGEAIRESGVPREELFVTTKLWNDDQRARRTEDAFQESLDRLGLD 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  81 YIDLFYIHFPIAFKFVpieekyppafycgdgdnfhyedvpilETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIK 160
Cdd:cd19126   97 YVDLYLIHWPGKDKFI--------------------------DTWKALEKLYASGKVKAIGVSNFQEHHLEELLAHADVV 150

                        170       180       190
                 ....*....|....*....|....*....|.
gi 461180628 161 PAVLQVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19126  151 PAVNQVEFHPYLTQKELRGYCKSKGIVVEAW 181
AKR_AKR5B1 cd19127
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ...
 5-189 3.07e-44

AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.


Pssm-ID: 381353 [Multi-domain]  Cd Length: 268  Bit Score: 147.55  E-value: 3.07e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   5 AADQVYQGIKAGYRLFDGAEDYGNEKEIGDGVKR-AIDeglvtREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYID 83
Cdd:cd19127   24 TADAVATALADGYRLIDTAAAYGNEREVGEGIRRsGVD-----RSDIFVTTKLWISDYGYDKALRGFDASLRRLGLDYVD 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  84 LFYIHFPIAFKFvpieekyppafycgdgDNfhyedvpILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPAV 163
Cdd:cd19127   99 LYLLHWPVPNDF----------------DR-------TIQAYKALEKLLAEGRVRAIGVSNFTPEHLERLIDATTVVPAV 155

                        170       180
                 ....*....|....*....|....*.
gi 461180628 164 LQVEHHPYLQQPKLIEFAQKAGlIVT 189
Cdd:cd19127  156 NQVELHPYFSQKDLRAFHRRLG-IVT 180
AKR_AKR3F3 cd19140
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ...
 5-191 3.80e-44

Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381366 [Multi-domain]  Cd Length: 253  Bit Score: 147.02  E-value: 3.80e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   5 AADQVYQGIKAGYRLFDGAEDYGNEKEIGdgvkRAIDEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYIDL 84
Cdd:cd19140   23 CTRAVEHALELGYRHIDTAQMYGNEAQVG----EAIAASGVPRDELFLTTKVWPDNYSPDDFLASVEESLRKLRTDYVDL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  85 FYIHFPIAfkfvpieekyppafycgdgdnfhyeDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPAVL 164
Cdd:cd19140   99 LLLHWPNK-------------------------DVPLAETLGALNEAQEAGLARHIGVSNFTVALLREAVELSEAPLFTN 153

                        170       180
                 ....*....|....*....|....*..
gi 461180628 165 QVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19140  154 QVEYHPYLDQRKLLDAAREHGIALTAY 180
AKR_CeZK1290-like cd19135
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ...
 9-191 6.26e-44

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381361 [Multi-domain]  Cd Length: 265  Bit Score: 146.70  E-value: 6.26e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   9 VYQGIKAGYRLFDGAEDYGNEKEIGdgvkRAIDEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYIDLFYIH 88
Cdd:cd19135   32 VYALKECGYRHIDTAKRYGCEELLG----KAIKESGVPREDLFLTTKLWPSDYGYESTKQAFEASLKRLGVDYLDLYLLH 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  89 FPiafkfvpieekyppafYCGDGDNFHYEdvPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPAVLQVEH 168
Cdd:cd19135  108 WP----------------DCPSSGKNVKE--TRAETWRALEELYDEGLCRAIGVSNFLIEHLEQLLEDCSVVPHVNQVEF 169

                        170       180
                 ....*....|....*....|...
gi 461180628 169 HPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19135  170 HPFQNPVELIEYCRDNNIVFEGY 192
AKR_AKR5A1_2 cd19156
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ...
 1-191 6.28e-40

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.


Pssm-ID: 381382 [Multi-domain]  Cd Length: 266  Bit Score: 136.49  E-value: 6.28e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAADQVYQGIKAGYRLFDGAEDYGNEKEIGDGVKraidEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVD 80
Cdd:cd19156   21 DGAEAENAVKWAIEAGYRHIDTAAIYKNEEGVGQGIR----ESGVPREEVFVTTKLWNSDQGYESTLAAFEESLEKLGLD 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  81 YIDLFYIHFPIAFKFVpieekyppafycgdgdnfhyedvpilETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIK 160
Cdd:cd19156   97 YVDLYLIHWPVKGKFK--------------------------DTWKAFEKLYKEKKVRAIGVSNFHEHHLEELLKSCKVA 150

                        170       180       190
                 ....*....|....*....|....*....|.
gi 461180628 161 PAVLQVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19156  151 PMVNQIELHPLLTQEPLRKFCKEKNIAVEAW 181
AKR_AKR5D1_E1 cd19132
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ...
 5-189 3.36e-38

AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381358 [Multi-domain]  Cd Length: 255  Bit Score: 131.62  E-value: 3.36e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   5 AADQVYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAidegLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYIDL 84
Cdd:cd19132   22 GVEAVVAALQAGYRLLDTAFNYENEGAVGEAVRRS----GVPREELFVTTKLPGRHHGYEEALRTIEESLYRLGLDYVDL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  85 FYIHFPiafkfVPIEEKYppafycgdgdnfhyedvpiLETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPAVL 164
Cdd:cd19132   98 YLIHWP-----NPSRDLY-------------------VEAWQALIEAREEGLVRSIGVSNFLPEHLDRLIDETGVTPAVN 153

                        170       180
                 ....*....|....*....|....*
gi 461180628 165 QVEHHPYLQQPKLIEFAQKAGlIVT 189
Cdd:cd19132  154 QIELHPYFPQAEQRAYHREHG-IVT 177
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 13-191 3.59e-38

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 132.82  E-value: 3.59e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   13 IKAGYRLFDGAEDYG---NEKEIGdgvkRAIDEGLVTREEIFLTSKLWNN------YHDPKNVEKALDKTLADLKVDYID 83
Cdd:pfam00248  28 LEAGINFIDTAEVYGdgkSEELLG----EALKDYPVKRDKVVIATKVPDGdgpwpsGGSKENIRKSLEESLKRLGTDYID 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   84 LFYIHFPiafkfvpieekyppafycgdgdnfhYEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPAV 163
Cdd:pfam00248 104 LYYLHWP-------------------------DPDTPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKALTKGKIPIVA 158

                         170       180       190
                  ....*....|....*....|....*....|
gi 461180628  164 LQVEHHPY--LQQPKLIEFAQKAGLIVTGY 191
Cdd:pfam00248 159 VQVEYNLLrrRQEEELLEYCKKNGIPLIAY 188
AKR_AKR3E1 cd19122
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ...
 9-191 7.20e-38

AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.


Pssm-ID: 381348 [Multi-domain]  Cd Length: 291  Bit Score: 131.98  E-value: 7.20e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   9 VYQGIKAGYRLFDGAEDYGNEKEIGDGVKRAIDEG-LVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYIDLFYI 87
Cdd:cd19122   30 VTKALDVGYRHLDCAWFYLNEDEVGDAVRDFLKENpSVKREDLFICTKVWNHLHEPEDVKWSIDNSLKNLKLDYIDLFLV 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  88 HFPIAF-KFVPIEEKYPPafycgDGDNFHYEDV-----PileTWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKP 161
Cdd:cd19122  110 HWPIAAeKNDQRSPKLGP-----DGKYVILKDLtenpeP---TWRAMEEIYESGKAKAIGVSNWTIPGLKKLLSFAKVKP 181

                        170       180       190
                 ....*....|....*....|....*....|
gi 461180628 162 AVLQVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19122  182 HVNQIEIHPFLPNEELVDYCFSNDILPEAY 211
AKR_AKR5C1 cd19130
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ...
 3-191 2.98e-36

Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.


Pssm-ID: 381356 [Multi-domain]  Cd Length: 256  Bit Score: 126.95  E-value: 2.98e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   3 AIAADQVYQGIKAGYRLFDGAEDYGNEKeigdGVKRAIDEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYI 82
Cdd:cd19130   23 ADTQRAVATALEVGYRHIDTAAIYGNEE----GVGAAIAASGIPRDELFVTTKLWNDRHDGDEPAAAFAESLAKLGLDQV 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  83 DLFYIHFPIafkfvpieekypPAfycgdGDNFhyedvpiLETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPA 162
Cdd:cd19130   99 DLYLVHWPT------------PA-----AGNY-------VHTWEAMIELRAAGRTRSIGVSNFLPPHLERIVAATGVVPA 154

                        170       180
                 ....*....|....*....|....*....
gi 461180628 163 VLQVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19130  155 VNQIELHPAYQQRTIRDWAQAHDVKIEAW 183
AKR_AKR3F2 cd19139
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ...
 7-191 2.75e-34

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381365 [Multi-domain]  Cd Length: 248  Bit Score: 121.31  E-value: 2.75e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   7 DQVYQGIKAGYRLFDGAEDYGNEKEIGdgvkRAIDEGLVTREEIFLTSKLW-NNYHDPKNVEkALDKTLADLKVDYIDLF 85
Cdd:cd19139   18 DSVRTALELGYRHIDTAQIYDNEAAVG----QAIAESGVPRDELFITTKIWiDNLSKDKLLP-SLEESLEKLRTDYVDLT 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  86 YIHFPiafkfvpieekyPPafycgdgdnfhYEDVPILETWKALEKLVASGKIRSIGVSNFPGALL---LDLLRGATIkpA 162
Cdd:cd19139   93 LIHWP------------SP-----------NDEVPVEEYIGALAEAKEQGLTRHIGVSNFTIALLdeaIAVVGAGAI--A 147

                        170       180
                 ....*....|....*....|....*....
gi 461180628 163 VLQVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19139  148 TNQIELSPYLQNRKLVAHCKQHGIHVTSY 176
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
5-177 3.49e-33

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 119.41  E-value: 3.49e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   5 AADQVYQGIKAGYRLFDGAEDYGNEKeigdGVKRAIDEGLVTREEIFLTSKLWNNyhDPKNVEKALDKTLADLKVDYIDL 84
Cdd:PRK11565  30 VITAIHKALEVGYRSIDTAAIYKNEE----GVGKALKEASVAREELFITTKLWND--DHKRPREALEESLKKLQLDYVDL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  85 FYIHFPiafkfVPIEEKYppafycgdgdnfhyedvpiLETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPAVL 164
Cdd:PRK11565 104 YLMHWP-----VPAIDHY-------------------VEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVIN 159

                        170
                 ....*....|...
gi 461180628 165 QVEHHPYLQQPKL 177
Cdd:PRK11565 160 QIELHPLMQQRQL 172
dkgB PRK11172
2,5-didehydrogluconate reductase DkgB;
7-191 6.79e-33

2,5-didehydrogluconate reductase DkgB;


Pssm-ID: 183012 [Multi-domain]  Cd Length: 267  Bit Score: 118.20  E-value: 6.79e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   7 DQVYQGIKAGYRLFDGAEDYGNEKEIGdgvkRAIDEGLVTREEIFLTSKLW-NNYHDPKNVEkALDKTLADLKVDYIDLF 85
Cdd:PRK11172  20 DSVKTALELGYRAIDTAQIYDNEAAVG----QAIAESGVPRDELFITTKIWiDNLAKDKLIP-SLKESLQKLRTDYVDLT 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  86 YIHFPiafkfvpieekyPPafycGDGdnfhyedVPILETWKALEKLVASGKIRSIGVSNFPGALL---LDLLRGATIkpA 162
Cdd:PRK11172  95 LIHWP------------SP----NDE-------VSVEEFMQALLEAKKQGLTREIGISNFTIALMkqaIAAVGAENI--A 149

                        170       180
                 ....*....|....*....|....*....
gi 461180628 163 VLQVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:PRK11172 150 TNQIELSPYLQNRKVVAFAKEHGIHVTSY 178
AKR_AKR5H1 cd19134
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ...
 3-191 2.58e-32

AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.


Pssm-ID: 381360 [Multi-domain]  Cd Length: 263  Bit Score: 116.88  E-value: 2.58e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   3 AIAADQVYQGIKAGYRLFDGAEDYGNEKEIGdgvkRAIDEGLVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYI 82
Cdd:cd19134   24 DEAERSVSAALEAGYRLIDTAAAYGNEAAVG----RAIAASGIPRGELFVTTKLATPDQGFTASQAACRASLERLGLDYV 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  83 DLFYIHFPiafkfVPIEEKYppafycgdgdnfhyedvpiLETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPA 162
Cdd:cd19134  100 DLYLIHWP-----AGREGKY-------------------VDSWGGLMKLREEGLARSIGVSNFTAEHLENLIDLTFFTPA 155

                        170       180
                 ....*....|....*....|....*....
gi 461180628 163 VLQVEHHPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19134  156 VNQIELHPLLNQAELRKVNAQHGIVTQAY 184
AKR_AKR3F1-like cd19072
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ...
 12-191 2.60e-31

Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381298 [Multi-domain]  Cd Length: 263  Bit Score: 114.25  E-value: 2.60e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  12 GIKAGYRLFDGAEDYGN---EKEIGdgvkRAIDEglVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYIDLFYIH 88
Cdd:cd19072   35 AIELGINLIDTAEMYGGghaEELVG----KAIKG--FDREDLFITTKVSPDHLKYDDVIKAAKESLKRLGTDYIDLYLIH 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  89 FPiafkfvpieekyppafycgdgdNFHyedVPILETWKALEKLVASGKIRSIGVSNFPGALL---LDLLRGATIkpAVLQ 165
Cdd:cd19072  109 WP----------------------NPS---IPIEETLRAMEELVEEGKIRYIGVSNFSLEELeeaQSYLKKGPI--VANQ 161

                        170       180
                 ....*....|....*....|....*...
gi 461180628 166 VEHHPYLQQP--KLIEFAQKAGLIVTGY 191
Cdd:cd19072  162 VEYNLFDREEesGLLPYCQKNGIAIIAY 189
AKR_AKR11B3 cd19085
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ...
 13-171 2.17e-28

Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.


Pssm-ID: 381311 [Multi-domain]  Cd Length: 292  Bit Score: 107.29  E-value: 2.17e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  13 IKAGYRLFDGAEDYGN---EKEIGDGVKRaideglvTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYIDLFYIHF 89
Cdd:cd19085   33 LDAGINFFDTAEAYGDghsEEVLGKALKG-------RRDDVVIATKVSPDNLTPEDVRKSCERSLKRLGTDYIDLYQIHW 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  90 PIafkfvpieekyppafycgdgdnfhyEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIkpAVLQVehh 169
Cdd:cd19085  106 PS-------------------------SDVPLEETMEALEKLKEEGKIRAIGVSNFGPAQLEEALDAGRI--DSNQL--- 155


                 ..
gi 461180628 170 PY 171
Cdd:cd19085  156 PY 157
PdxI COG0667
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ...
 15-191 4.37e-27

Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440431 [Multi-domain]  Cd Length: 316  Bit Score: 104.10  E-value: 4.37e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  15 AGYRLFDGAEDYG---NEKEIGDGVKRaideglVTREEIFLTSKLWNNYHD--------PKNVEKALDKTLADLKVDYID 83
Cdd:COG0667   45 AGINFFDTADVYGpgrSEELLGEALKG------RPRDDVVIATKVGRRMGPgpngrglsREHIRRAVEASLRRLGTDYID 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  84 LFYIHFPiafkfvpieekyppafycgdgDnfhyEDVPILETWKALEKLVASGKIRSIGVSNFPGALL---LDLLRGATiK 160
Cdd:COG0667  119 LYQLHRP---------------------D----PDTPIEETLGALDELVREGKIRYIGVSNYSAEQLrraLAIAEGLP-P 172

                        170       180       190
                 ....*....|....*....|....*....|...
gi 461180628 161 PAVLQVEHHPYLQQP--KLIEFAQKAGLIVTGY 191
Cdd:COG0667  173 IVAVQNEYSLLDRSAeeELLPAARELGVGVLAY 205
AKR_SF cd06660
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 15-191 2.76e-26

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


Pssm-ID: 381296 [Multi-domain]  Cd Length: 232  Bit Score: 100.29  E-value: 2.76e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  15 AGYRLFDGAEDYGN---EKEIGdgvkRAIdEGLVTREEIFLTSKL--------WNNYHDPKNVEKALDKTLADLKVDYID 83
Cdd:cd06660   29 AGGNFFDTADVYGDgrsERLLG----RWL-KGRGNRDDVVIATKGghppggdpSRSRLSPEHIRRDLEESLRRLGTDYID 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  84 LFYIHFPIafkfvpieekyppafycgdgdnfhyEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGAT----I 159
Cdd:cd06660  104 LYYLHRDD-------------------------PSTPVEETLEALNELVREGKIRYIGVSNWSAERLAEALAYAKahglP 158

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 461180628 160 KPAVLQVEH---HPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd06660  159 GFAAVQPQYsllDRSPMEEELLDWAEENGLPLLAY 193
AKR_AKR11B1-like cd19084
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ...
 1-191 2.38e-24

AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381310 [Multi-domain]  Cd Length: 296  Bit Score: 96.44  E-value: 2.38e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAAdqVYQGIKAGYRLFDGAEDYGN---EKEIGDGVKRaideglvTREEIFLTSK---LWNN----YHD--PKNVEK 68
Cdd:cd19084   25 QESIEA--IKAAIDLGINFFDTAPVYGFghsEEILGKALKG-------RRDDVVIATKcglRWDGgkgvTKDlsPESIRK 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  69 ALDKTLADLKVDYIDLFYIHFPiafkfvpieekyppafycgdgDnfhyEDVPILETWKALEKLVASGKIRSIGVSNFPGA 148
Cdd:cd19084   96 EVEQSLRRLQTDYIDLYQIHWP---------------------D----PNTPIEETAEALEKLKKEGKIRYIGVSNFSVE 150

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 461180628 149 LLLDLLRgaTIKPAVLQVEHHPYLQQP--KLIEFAQKAGLIVTGY 191
Cdd:cd19084  151 QLEEARK--YGPIVSLQPPYSMLEREIeeELLPYCRENGIGVLPY 193
AKR_YeaE cd19138
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ...
 12-169 2.03e-23

Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381364 [Multi-domain]  Cd Length: 266  Bit Score: 93.47  E-value: 2.03e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  12 GIKAGYRLFDGAEDYGN---EKEIGDgvkrAIDEglvTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYIDLFYIH 88
Cdd:cd19138   38 GIDLGMTLIDTAEMYGDggsEELVGE----AIRG---RRDKVFLVSKVLPSNASRQGTVRACERSLRRLGTDYLDLYLLH 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  89 FPiafkfvpieekyppafycgdgdnfhyEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKP-AVLQVE 167
Cdd:cd19138  111 WR--------------------------GGVPLAETVAAMEELKKEGKIRAWGVSNFDTDDMEELWAVPGGGNcAANQVL 164


                 ..
gi 461180628 168 HH 169
Cdd:cd19138  165 YN 166
AKR_AtPLR-like cd19093
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ...
 13-191 2.65e-20

Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.


Pssm-ID: 381319 [Multi-domain]  Cd Length: 293  Bit Score: 85.74  E-value: 2.65e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  13 IKAGYRLFDGAEDYGN---EKEIGdgvkRAIDEgLVTREEIFLTSKL----WNNYHDPknVEKALDKTLADLKVDYIDLF 85
Cdd:cd19093   36 LEAGVNLFDTAEVYGTgrsERLLG----RFLKE-LGDRDEVVIATKFaplpWRLTRRS--VVKALKASLERLGLDSIDLY 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  86 YIHFPIAFkfvpieekYPPafycgdgdnfhyedvpILETWKALEKLVASGKIRSIGVSNFPGALL---LDLLRGATIKPA 162
Cdd:cd19093  109 QLHWPGPW--------YSQ----------------IEALMDGLADAVEEGLVRAVGVSNYSADQLrraHKALKERGVPLA 164

                        170       180       190
                 ....*....|....*....|....*....|..
gi 461180628 163 VLQVEH---HPYLQQPKLIEFAQKAGLIVTGY 191
Cdd:cd19093  165 SNQVEYsllYRDPEQNGLLPACDELGITLIAY 196
AKR_AKR11C1 cd19086
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ...
 1-188 6.03e-20

AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.


Pssm-ID: 381312 [Multi-domain]  Cd Length: 238  Bit Score: 83.68  E-value: 6.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAAdqVYQGIKAGYRLFDGAEDYGN---EKEIGDGVKRaideglvTREEIFLTSKLWNNYH---------DPKNVEK 68
Cdd:cd19086   24 AEAIRA--LRAALDLGINFFDTADVYGDghsERLLGKALKG-------RRDKVVIATKFGNRFDggperpqdfSPEYIRE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  69 ALDKTLADLKVDYIDLFYIHFPiafkfvpieekyppafycgdgdnfHYEDVPILETWKALEKLVASGKIRSIGVSNFPGA 148
Cdd:cd19086   95 AVEASLKRLGTDYIDLYQLHNP------------------------PDEVLDNDELFEALEKLKQEGKIRAYGVSVGDPE 150

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 461180628 149 LLLDLLRGATIkpAVLQVEHHPYLQQP--KLIEFAQKAGLIV 188
Cdd:cd19086  151 EALAALRRGGI--DVVQVIYNLLDQRPeeELFPLAEEHGVGV 190
AKR_unchar cd19102
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 3-165 1.32e-19

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381328 [Multi-domain]  Cd Length: 302  Bit Score: 83.88  E-value: 1.32e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   3 AIAAdqVYQGIKAGYRLFDGAEDYG---NEKEIGdgvkRAIDEglvTREEIFLTSK---LWN------NYHDPKNVEKAL 70
Cdd:cd19102   28 SIAA--IRAALDLGINWIDTAAVYGlghSEEVVG----RALKG---LRDRPIVATKcglLWDeegrirRSLKPASIRAEC 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  71 DKTLADLKVDYIDLFYIHFPiafkfvpieekyppafycgdgdnfhYEDVPILETWKALEKLVASGKIRSIGVSNFPGAll 150
Cdd:cd19102   99 EASLRRLGVDVIDLYQIHWP-------------------------DPDEPIEEAWGALAELKEEGKVRAIGVSNFSVD-- 151

                        170
                 ....*....|....*.
gi 461180628 151 lDLLRGATIKP-AVLQ 165
Cdd:cd19102  152 -QMKRCQAIHPiASLQ 166
AKR_AKR3F1 cd19137
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ...
 12-191 3.60e-19

Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381363 [Multi-domain]  Cd Length: 260  Bit Score: 82.23  E-value: 3.60e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  12 GIKAGYRLFDGAEDYG---NEKEIGDGVKRaideglVTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKVDYIDLFYIH 88
Cdd:cd19137   35 AIELGYTHIDTAEMYGgghTEELVGKAIKD------FPREDLFIVTKVWPTNLRYDDLLRSLQNSLRRLDTDYIDLYLIH 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  89 FPiafkfvpieekyppafycgdgdnfhYEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGATIKPAVLQVEH 168
Cdd:cd19137  109 WP-------------------------NPNIPLEETLSAMAEGVRQGLIRYIGVSNFNRRLLEEAISKSQTPIVCNQVKY 163

                        170       180
                 ....*....|....*....|....*.
gi 461180628 169 HPYLQQPK---LIEFAQKAGLIVTGY 191
Cdd:cd19137  164 NLEDRDPErdgLLEYCQKNGITVVAY 189
AKR_AKR12A1_B1_C1 cd19087
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ...
 15-147 5.18e-19

AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.


Pssm-ID: 381313 [Multi-domain]  Cd Length: 310  Bit Score: 82.24  E-value: 5.18e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  15 AGYRLFDGAEDYGN---EKEIGdgvkRAIDEglvTREEIFLTSKLWNNYHDP--------KNVEKALDKTLADLKVDYID 83
Cdd:cd19087   42 AGINFFDTADVYGGgrsEEIIG----RWIAG---RRDDIVLATKVFGPMGDDpndrglsrRHIRRAVEASLRRLQTDYID 114

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 461180628  84 LFYIHfpiafkfvpieekyppafycgdgdnfHY-EDVPILETWKALEKLVASGKIRSIGVSNFPG 147
Cdd:cd19087  115 LYQMH--------------------------HFdRDTPLEETLRALDDLVRQGKIRYIGVSNFAA 153
AKR_AKR13A_13D cd19076
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ...
 13-167 1.80e-18

AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381302 [Multi-domain]  Cd Length: 303  Bit Score: 80.72  E-value: 1.80e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  13 IKAGYRLFDGAEDYG---NEKEIGdgvkRAIDEGlvtREEIFLTSKL--------WNNYHD--PKNVEKALDKTLADLKV 79
Cdd:cd19076   42 LELGVTFLDTADMYGpgtNEELLG----KALKDR---RDEVVIATKFgivrdpgsGFRGVDgrPEYVRAACEASLKRLGT 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  80 DYIDLFYIHFPiafkfvpieekyPPafycgdgdnfhyeDVPILETWKALEKLVASGKIRSIGVSNFPGAlllDLLRGATI 159
Cdd:cd19076  115 DVIDLYYQHRV------------DP-------------NVPIEETVGAMAELVEEGKVRYIGLSEASAD---TIRRAHAV 166


                 ....*....
gi 461180628 160 KP-AVLQVE 167
Cdd:cd19076  167 HPiTAVQSE 175
AKR_unchar cd19099
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 9-188 5.25e-18

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381325 [Multi-domain]  Cd Length: 316  Bit Score: 79.67  E-value: 5.25e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   9 VYQGIKAGYRLFDGAEDYGN---EKEIGDGVKRAIDEGLVTREEIFLTSK------------------------------ 55
Cdd:cd19099   27 LKAALDSGINVIDTAINYRGgrsERLIGKALRELIEKGGIKRDEVVIVTKagyipgdgdeplrplkyleeklgrglidva 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  56 ----LWNNYHdPKNVEKALDKTLADLKVDYIDLFYIHFPIAFKFVPIEEKYppafycgdgdnfhYEDvpILETWKALEKL 131
Cdd:cd19099  107 dsagLRHCIS-PAYLEDQIERSLKRLGLDTIDLYLLHNPEEQLLELGEEEF-------------YDR--LEEAFEALEEA 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628 132 VASGKIRSIGVS-------NFPGALLLDLLRGATIKPAVLQVEHH-PYLQQP--------------------KLIEFAQK 183
Cdd:cd19099  171 VAEGKIRYYGIStwdgfraPPALPGHLSLEKLVAAAEEVGGDNHHfKVIQLPlnllepealtekntvkgealSLLEAAKE 250


                 ....*
gi 461180628 184 AGLIV 188
Cdd:cd19099  251 LGLGV 255
AKR_PA4992-like cd19095
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ...
 13-188 2.41e-17

Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381321 [Multi-domain]  Cd Length: 253  Bit Score: 76.89  E-value: 2.41e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  13 IKAGYRLFDGAEDYGN-EKEIGDGVKRaideglVTREEIFLTSKLW------NNYHD--PKNVEKALDKTLADLKVDYID 83
Cdd:cd19095   30 LDLGINLIDTAPAYGRsEERLGRALAG------LRRDDLFIATKVGthgeggRDRKDfsPAAIRASIERSLRRLGTDYID 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  84 LFYIHFPiafkfvPIEEKYPPAFycgdgdnfhyedvpiletwKALEKLVASGKIRSIGVSNFpGALLLDLLRGATIkpAV 163
Cdd:cd19095  104 LLQLHGP------SDDELTGEVL-------------------ETLEDLKAAGKVRYIGVSGD-GEELEAAIASGVF--DV 155

                        170       180
                 ....*....|....*....|....*.
gi 461180628 164 LQVEHHPYLQ-QPKLIEFAQKAGLIV 188
Cdd:cd19095  156 VQLPYNVLDReEEELLPLAAEAGLGV 181
AKR_unchar cd19105
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 13-143 2.27e-16

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381331 [Multi-domain]  Cd Length: 250  Bit Score: 74.54  E-value: 2.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  13 IKAGYRLFDGAEDYGN---EKEIGDGVKRaideglVTREEIFLTSK--LWNNYHDPKNVEKALDKTLADLKVDYIDLFYI 87
Cdd:cd19105   35 LDLGINYFDTAEGYGNgnsEEIIGEALKG------LRRDKVFLATKasPRLDKKDKAELLKSVEESLKRLQTDYIDIYQL 108

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 461180628  88 HFPiafkfvpieekyppafycgDGDNFHYEDVPILEtwkALEKLVASGKIRSIGVS 143
Cdd:cd19105  109 HGV-------------------DTPEERLLNEELLE---ALEKLKKEGKVRFIGFS 142
COG1453 COG1453
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
1-143 2.76e-16

Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];


Pssm-ID: 441062 [Multi-domain]  Cd Length: 365  Bit Score: 75.24  E-value: 2.76e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAADQVYQGIKAGYRLFDGAEDYGN-EKEIGDGVKRaideglvTREEIFLTSKLWNNYHDPKNVEKALDKTLADLKV 79
Cdd:COG1453   27 DEEEAEALIRRAIDNGINYIDTARGYGDsEEFLGKALKG-------PRDKVILATKLPPWVRDPEDMRKDLEESLKRLQT 99

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 461180628  80 DYIDLFYIHfpiafkfvpieekyppafYCGDGDNFHYEDVPiLETWKALEKLVASGKIRSIGVS 143
Cdd:COG1453  100 DYIDLYLIH------------------GLNTEEDLEKVLKP-GGALEALEKAKAEGKIRHIGFS 144
AKR_unchar cd19100
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 13-190 6.95e-16

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381326 [Multi-domain]  Cd Length: 238  Bit Score: 72.90  E-value: 6.95e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  13 IKAGYRLFDGAEDYGN-EKEIGDGVKRAideglvtREEIFLTSKLWNnyHDPKNVEKALDKTLADLKVDYIDLFYIHfpi 91
Cdd:cd19100   37 LDLGINYFDTAPSYGDsEEKIGKALKGR-------RDKVFLATKTGA--RDYEGAKRDLERSLKRLGTDYIDLYQLH--- 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  92 afkFVPIEEKYPPAFYCGdgdnfhyedvpilETWKALEKLVASGKIRSIGVSN-FPGALLLDLLRGA--TIKPAVLQVEH 168
Cdd:cd19100  105 ---AVDTEEDLDQVFGPG-------------GALEALLEAKEEGKIRFIGISGhSPEVLLRALETGEfdVVLFPINPAGD 168

                        170       180
                 ....*....|....*....|..
gi 461180628 169 HPYLQQPKLIEFAQKAGLIVTG 190
Cdd:cd19100  169 HIDSFREELLPLAREKGVGVIA 190
AKR_EcYajO-like cd19079
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ...
 11-191 9.06e-16

Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381305 [Multi-domain]  Cd Length: 312  Bit Score: 73.39  E-value: 9.06e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  11 QGIKAGYRLFDGAEDYGN---EKEIGDGVKRAIDeglvtREEIFLTSKLWNNYHDP--------KNVEKALDKTLADLKV 79
Cdd:cd19079   43 RALDLGINFFDTANVYSGgasEEILGRALKEFAP-----RDEVVIATKVYFPMGDGpngrglsrKHIMAEVDASLKRLGT 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  80 DYIDLFYIHfpiafkfvpieekyppafycgdgdNFHYEdVPILETWKALEKLVASGKIRSIGVSNFPG-----ALLLDLL 154
Cdd:cd19079  118 DYIDLYQIH------------------------RWDYE-TPIEETLEALHDVVKSGKVRYIGASSMYAwqfakALHLAEK 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 461180628 155 RGATiKPAVLQvEHHPYLQQP---KLIEFAQKAGLIVTGY 191
Cdd:cd19079  173 NGWT-KFVSMQ-NHYNLLYREeerEMIPLCEEEGIGVIPW 210
AKR_Tas-like cd19094
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ...
 61-144 2.10e-15

Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.


Pssm-ID: 381320 [Multi-domain]  Cd Length: 328  Bit Score: 72.60  E-value: 2.10e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  61 HDPKNVEKALDKTLADLKVDYIDLFYIHFPiafkfvpieEKYPPAFYCGDGDNFHYED--VPILETWKALEKLVASGKIR 138
Cdd:cd19094   93 LDRENIREAVEGSLKRLGTDYIDLYQLHWP---------DRYTPLFGGGYYTEPSEEEdsVSFEEQLEALGELVKAGKIR 163


                 ....*.
gi 461180628 139 SIGVSN 144
Cdd:cd19094  164 HIGLSN 169
AKR_AKR11A1_11D1 cd19083
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ...
 1-145 3.37e-15

AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).


Pssm-ID: 381309 [Multi-domain]  Cd Length: 307  Bit Score: 72.07  E-value: 3.37e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAADQVYQGIKAGYRLFDGAEDYG---NEKEIGDGVKRAideglvTREEIFLTSK----------LWNNyhDPKNVE 67
Cdd:cd19083   31 DEEEGKDLVREALDNGVNLLDTAFIYGlgrSEELVGEVLKEY------NRNEVVIATKgahkfggdgsVLNN--SPEFLR 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 461180628  68 KALDKTLADLKVDYIDLFYIHFPiafkfvpieekyppafycgDGdnfhyeDVPILETWKALEKLVASGKIRSIGVSNF 145
Cdd:cd19083  103 SAVEKSLKRLNTDYIDLYYIHFP-------------------DG------ETPKAEAVGALQELKDEGKIRAIGVSNF 155
Aldo_ket_red_shaker-like cd19074
Shaker potassium channel beta subunit family and similar proteins; This family includes ...
 4-191 3.89e-15

Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381300 [Multi-domain]  Cd Length: 297  Bit Score: 71.47  E-value: 3.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   4 IAADQVYQGIKAGYRLFDGAEDYGN---EKEIGDGVKRaideglVTREEIFLTSKL-WNNYHDP-------KNVEKALDK 72
Cdd:cd19074   23 DAKACVRKAYDLGINFFDTADVYAAgqaEEVLGKALKG------WPRESYVISTKVfWPTGPGPndrglsrKHIFESIHA 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  73 TLADLKVDYIDLFYIHFPiafkfvpieekyppafycgdgdnfhYEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLD 152
Cdd:cd19074   97 SLKRLQLDYVDIYYCHRY-------------------------DPETPLEETVRAMDDLIRQGKILYWGTSEWSAEQIAE 151

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 461180628 153 LLRGAT----IKPAVLQVEHHpYLQQPK---LIEFAQKAGLIVTGY 191
Cdd:cd19074  152 AHDLARqfglIPPVVEQPQYN-MLWREIeeeVIPLCEKNGIGLVVW 196
AKR_AKR13A1 cd19144
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ...
 13-171 1.13e-14

AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.


Pssm-ID: 381370 [Multi-domain]  Cd Length: 323  Bit Score: 70.55  E-value: 1.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  13 IKAGYRLFDGAEDYG-NEKEIGDGVKRAIDeglvTREEIFLTSK-----------LWNNyHDPKNVEKALDKTLADLKVD 80
Cdd:cd19144   44 FELGCTFWDTADIYGdSEELIGRWFKQNPG----KREKIFLATKfgieknvetgeYSVD-GSPEYVKKACETSLKRLGVD 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  81 YIDLFYIHfpiafKFVPieekyppafycgdgdnfhyeDVPILETWKALEKLVASGKIRSIGVSNFPGAlllDLLRGATIK 160
Cdd:cd19144  119 YIDLYYQH-----RVDG--------------------KTPIEKTVAAMAELVQEGKIKHIGLSECSAE---TLRRAHAVH 170

                        170
                 ....*....|..
gi 461180628 161 P-AVLQVEHHPY 171
Cdd:cd19144  171 PiAAVQIEYSPF 182
AKR_AKR11B1 cd19148
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ...
 1-145 1.14e-13

Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381374 [Multi-domain]  Cd Length: 302  Bit Score: 67.72  E-value: 1.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAADQVYQGIKAGYRLFDGAEDYG--NEKEIgdgVKRAIdEGLVTREEIFLTSKL---WNNYH------DPKNVEKA 69
Cdd:cd19148   23 DEKEAIETIHKALDLGINLIDTAPVYGfgLSEEI---VGKAL-KEYGKRDRVVIATKVgleWDEGGevvrnsSPARIRKE 98

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 461180628  70 LDKTLADLKVDYIDLFYIHFPiafkfvpieekyppafycgDgdnfhyEDVPILETWKALEKLVASGKIRSIGVSNF 145
Cdd:cd19148   99 VEDSLRRLQTDYIDLYQVHWP-------------------D------PLVPIEETAEALKELLDEGKIRAIGVSNF 149
AKR_AKR10A1_2 cd19082
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ...
 15-144 1.21e-13

AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.


Pssm-ID: 381308 [Multi-domain]  Cd Length: 291  Bit Score: 67.58  E-value: 1.21e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  15 AGYRLFDGAEDYGN-------EKEIGDGVK-RAIdeglvtREEIFLTSK--------LWNNYHDPKNVEKALDKTLADLK 78
Cdd:cd19082   29 LGGNFIDTARVYGDwvergasERVIGEWLKsRGN------RDKVVIATKgghpdledMSRSRLSPEDIRADLEESLERLG 102

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 461180628  79 VDYIDLFYIHFpiafkfvpieekyppafycgdgDNfhyEDVP---ILETwkaLEKLVASGKIRSIGVSN 144
Cdd:cd19082  103 TDYIDLYFLHR----------------------DD---PSVPvgeIVDT---LNELVRAGKIRAFGASN 143
AKR_AKR9A_9B cd19080
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ...
 15-169 6.19e-13

AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.


Pssm-ID: 381306 [Multi-domain]  Cd Length: 307  Bit Score: 65.70  E-value: 6.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  15 AGYRLFDGAEDYGN---EKEIGDGVKRaideglvTREEIFLTSKLWNNYH--DP-------KNVEKALDKTLADLKVDYI 82
Cdd:cd19080   43 AGGNFIDTANNYTNgtsERLLGEFIAG-------NRDRIVLATKYTMNRRpgDPnaggnhrKNLRRSVEASLRRLQTDYI 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  83 DLFYIHFPiafkfvpieekyppafycgDGDnfhyedVPILETWKALEKLVASGKIRSIGVSNFP-----GALLLDLLRGA 157
Cdd:cd19080  116 DLLYVHAW-------------------DFT------TPVEEVMRALDDLVRAGKVLYVGISDTPawvvaRANTLAELRGW 170

                        170
                 ....*....|..
gi 461180628 158 TiKPAVLQVEHH 169
Cdd:cd19080  171 S-PFVALQIEYS 181
AKR_AKR9C1 cd19081
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ...
 63-191 6.96e-13

AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).


Pssm-ID: 381307 [Multi-domain]  Cd Length: 308  Bit Score: 65.31  E-value: 6.96e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  63 PKNVEKALDKTLADLKVDYIDLFYIHFPiafkfvpieekyppafycgdgDnfhyEDVPILETWKALEKLVASGKIRSIGV 142
Cdd:cd19081   97 RKHIRRAVEASLRRLQTDYIDLYQAHWD---------------------D----PATPLEETLGALNDLIRQGKVRYIGA 151

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 461180628 143 SNFPGALL---LDLLRGA-TIKPAVLQVEHHPYLQQP---KLIEFAQKAGLIVTGY 191
Cdd:cd19081  152 SNYSAWRLqeaLELSRQHgLPRYVSLQPEYNLVDRESfegELLPLCREEGIGVIPY 207
AKR_AKR15A-like cd19090
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ...
 1-155 1.35e-12

AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381316 [Multi-domain]  Cd Length: 278  Bit Score: 64.50  E-value: 1.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAAdqVYQGIKAGYRLFDGAEDYGN-EKEIGDGVKRaideglVTREEIFLTSKL-----WNNYHDPKNVEKALDKTL 74
Cdd:cd19090   20 DEAVAT--IRAALDLGINYIDTAPAYGDsEERLGLALAE------LPREPLVLSTKVgrlpeDTADYSADRVRRSVEESL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  75 ADLKVDYIDLFYIHFPiafkfvpieEKYPPAFYCGDGdnfhyedvPILEtwkALEKLVASGKIRSIGVSNFPGALLLDLL 154
Cdd:cd19090   92 ERLGRDRIDLLMIHDP---------ERVPWVDILAPG--------GALE---ALLELKEEGLIKHIGLGGGPPDLLRRAI 151


                 .
gi 461180628 155 R 155
Cdd:cd19090  152 E 152
tas PRK10625
putative aldo-keto reductase; Provisional
 3-144 2.11e-12

putative aldo-keto reductase; Provisional


Pssm-ID: 236727 [Multi-domain]  Cd Length: 346  Bit Score: 64.49  E-value: 2.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   3 AIAADQVYQGIKAGYRLFDGAEDYG----------NEKEIGDGVKRAideglVTREEIFLTSKL----WNNYH------- 61
Cdd:PRK10625  30 ADAHAQLDYAVAQGINLIDVAEMYPvpprpetqglTETYIGNWLAKR-----GSREKLIIASKVsgpsRNNDKgirpnqa 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  62 -DPKNVEKALDKTLADLKVDYIDLFYIHFPiafkfvpieeKYPPAFYcgdGD-NFHYED----VPILETWKALEKLVASG 135
Cdd:PRK10625 105 lDRKNIREALHDSLKRLQTDYLDLYQVHWP----------QRPTNCF---GKlGYSWTDsapaVSLLETLDALAEQQRAG 171


                 ....*....
gi 461180628 136 KIRSIGVSN 144
Cdd:PRK10625 172 KIRYIGVSN 180
AKR_AKR11B2 cd19149
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ...
 1-145 3.43e-12

Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381375 [Multi-domain]  Cd Length: 315  Bit Score: 63.45  E-value: 3.43e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAADQVYQGIKAGYRLFDGAEDYGN---EKEIGDGVKRAIDE-------GLVTREEifLTSKLW-------NNYHDP 63
Cdd:cd19149   31 DDNESIRTIHAALDLGINLIDTAPAYGFghsEEIVGKAIKGRRDKvvlatkcGLRWDRE--GGSFFFvrdgvtvYKNLSP 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  64 KNVEKALDKTLADLKVDYIDLFYIHFPiafkfvpieekyppafycgdgdnfhyeDV--PILETWKALEKLVASGKIRSIG 141
Cdd:cd19149  109 ESIREEVEQSLKRLGTDYIDLYQTHWQ---------------------------DVetPIEETMEALEELKRQGKIRAIG 161


                 ....
gi 461180628 142 VSNF 145
Cdd:cd19149  162 ASNV 165
AKR_AKR13C1_2 cd19078
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ...
 9-143 5.07e-12

AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.


Pssm-ID: 381304 [Multi-domain]  Cd Length: 301  Bit Score: 63.02  E-value: 5.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   9 VYQGIKAGYRLFDGAEDYG---NEKEIGDGVKRaideglvTREEIFLTSKL-WNNYHD----------PKNVEKALDKTL 74
Cdd:cd19078   31 IRKAVELGITFFDTAEVYGpytNEELVGEALKP-------FRDQVVIATKFgFKIDGGkpgplgldsrPEHIRKAVEGSL 103

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 461180628  75 ADLKVDYIDLFYIHfpiafkfvpieeKYPPafycgdgdnfhyeDVPILETWKALEKLVASGKIRSIGVS 143
Cdd:cd19078  104 KRLQTDYIDLYYQH------------RVDP-------------NVPIEEVAGTMKELIKEGKIRHWGLS 147
AKR_AKR14A1_2 cd19089
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ...
 20-185 6.13e-12

AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.


Pssm-ID: 381315 [Multi-domain]  Cd Length: 308  Bit Score: 62.66  E-value: 6.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  20 FDGAEDYGN-----EKEIGdgvkRAIDEGLVT-REEIFLTSK----LW----NNYHDPKNVEKALDKTLADLKVDYIDLF 85
Cdd:cd19089   46 FDLANNYGPppgsaEENFG----RILKRDLRPyRDELVISTKagygMWpgpyGDGGSRKYLLASLDQSLKRMGLDYVDIF 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  86 YIHfpiafkfvpieeKYPPafycgdgdnfhyeDVPILETWKALEKLVASGKIRSIGVSNFPGALL---LDLLRGATIKPA 162
Cdd:cd19089  122 YHH------------RYDP-------------DTPLEETMTALADAVRSGKALYVGISNYPGAKArraIALLRELGVPLI 176

                        170       180
                 ....*....|....*....|....*
gi 461180628 163 VLQVEHHPYLQQPK--LIEFAQKAG 185
Cdd:cd19089  177 IHQPRYSLLDRWAEdgLLEVLEEAG 201
AKR_AKR7A1-5 cd19075
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ...
 14-165 1.06e-11

AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.


Pssm-ID: 381301 [Multi-domain]  Cd Length: 304  Bit Score: 62.19  E-value: 1.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  14 KAGYRLFDGAEDYGN---EKEIGdgvkraidEGLVTREEIFLTSK---LWNNYHDPKNVEKALDKTLADLKVDYIDLFYI 87
Cdd:cd19075   31 ERGHTEIDTARVYPDgtsEELLG--------ELGLGERGFKIDTKanpGVGGGLSPENVRKQLETSLKRLKVDKVDVFYL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  88 HFPiafkfvpieekyppafycgDgdnfhyEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGAT----IKPAV 163
Cdd:cd19075  103 HAP-------------------D------RSTPLEETLAAIDELYKEGKFKEFGLSNYSAWEVAEIVEICKengwVLPTV 157


                 ..
gi 461180628 164 LQ 165
Cdd:cd19075  158 YQ 159
AKR_unchar cd19103
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 15-145 1.11e-11

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381329 [Multi-domain]  Cd Length: 299  Bit Score: 61.97  E-value: 1.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  15 AGYRLFDGAEDYG---NEKEIGDGVKRaideglVTREEIFLTSK----LWNNYHDPknVEKALDKTLADLKVDYIDLFYI 87
Cdd:cd19103   44 AGLNLWDTAAVYGmgaSEKILGEFLKR------YPREDYIISTKftpqIAGQSADP--VADMLEGSLARLGTDYIDIYWI 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 461180628  88 HFPIafkfvpieekyppafycgdgdnfhyeDVpilETW-KALEKLVASGKIRSIGVSNF 145
Cdd:cd19103  116 HNPA--------------------------DV---ERWtPELIPLLKSGKVKHVGVSNH 145
AKR_BsYcsN_EcYdhF-like cd19092
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ...
 13-171 1.28e-11

Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.


Pssm-ID: 381318 [Multi-domain]  Cd Length: 287  Bit Score: 61.80  E-value: 1.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  13 IKAGYRLFDGAEDYGN---EKEIGDGVKRaiDEGLvtREEIFLTSK-----------LWNNYHD--PKNVEKALDKTLAD 76
Cdd:cd19092   34 LELGITTFDHADIYGGgkcEELFGEALAL--NPGL--REKIEIQTKcgirlgddprpGRIKHYDtsKEHILASVEGSLKR 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  77 LKVDYIDLFYIHFPIAFkfvpieekyppafycgdgdnFHYEdvpilETWKALEKLVASGKIRSIGVSNFPGAlLLDLLRG 156
Cdd:cd19092  110 LGTDYLDLLLLHRPDPL--------------------MDPE-----EVAEAFDELVKSGKVRYFGVSNFTPS-QIELLQS 163

                        170
                 ....*....|....*.
gi 461180628 157 ATIKPAVL-QVEHHPY 171
Cdd:cd19092  164 YLDQPLVTnQIELSLL 179
AKR_unchar cd19752
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 7-146 1.30e-11

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381391 [Multi-domain]  Cd Length: 291  Bit Score: 61.58  E-value: 1.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   7 DQVYQgikAGYRLFDGAEDYG--NEKEIGDGVKRAIDEGLV---TREEIFLTSKLWNNYHDP------------KNVEKA 69
Cdd:cd19752   24 DRYVA---AGGNFLDTANNYAfwTEGGVGGESERLIGRWLKdrgNRDDVVIATKVGAGPRDPdggpespeglsaETIEQE 100

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 461180628  70 LDKTLADLKVDYIDLFYIHfpiafkfvpIEEKyppafycgdgdnfhyeDVPILETWKALEKLVASGKIRSIGVSNFP 146
Cdd:cd19752  101 IDKSLRRLGTDYIDLYYAH---------VDDR----------------DTPLEETLEAFNELVKAGKVRAIGASNFA 152
AKR_unchar cd19104
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 1-143 2.06e-11

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381330 [Multi-domain]  Cd Length: 321  Bit Score: 61.51  E-value: 2.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAAdqVYQGIKAGYRLFDGAEDYGN---EKEIGdgvkRAIDEglvTREEIFLTSKLWNNYHDPKN----VEKALDKT 73
Cdd:cd19104   32 EEQIAA--VRRALDLGINFFDTAPSYGDgksEENLG----RALKG---LPAGPYITTKVRLDPDDLGDiggqIERSVEKS 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  74 LADLKVDYIDLFYIHFPIafkfvpIEEKYPPAFYCGDGDNFHYEDvpilETWKALEKLVASGKIRSIGVS 143
Cdd:cd19104  103 LKRLKRDSVDLLQLHNRI------GDERDKPVGGTLSTTDVLGLG----GVADAFERLRSEGKIRFIGIT 162
AKR_ARA2 cd19164
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ...
 6-183 5.73e-11

D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381390 [Multi-domain]  Cd Length: 298  Bit Score: 59.98  E-value: 5.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   6 ADQVYQGIKAGYRLFDGAEDYGNEKEI-GDGVKRAIDEglVTREEIFLTSK---LWNNYHD--PKNVEKALDKTLADLKV 79
Cdd:cd19164   37 VDIVRRALELGIRAFDTSPYYGPSEIIlGRALKALRDE--FPRDTYFIITKvgrYGPDDFDysPEWIRASVERSLRRLHT 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  80 DYIDLFYIHfpiAFKFVPIEEkyppafycgdgdnfhyedvpILETWKALEKLVASGKIRSIGVSNFPGALLLDLLRGA-- 157
Cdd:cd19164  115 DYLDLVYLH---DVEFVADEE--------------------VLEALKELFKLKDEGKIRNVGISGYPLPVLLRLAELArt 171

                        170       180
                 ....*....|....*....|....*....
gi 461180628 158 -TIKP--AVLQVEHHPyLQQPKLIEFAQK 183
Cdd:cd19164  172 tAGRPldAVLSYCHYT-LQNTTLLAYIPK 199
AKR_galDH cd19163
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ...
 3-155 7.25e-11

L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).


Pssm-ID: 381389 [Multi-domain]  Cd Length: 293  Bit Score: 59.49  E-value: 7.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   3 AIAAdqVYQGIKAGYRLFDGAEDYGN---EKEIGDGVKraidegLVTREEIFLTSK------LWNNYHD--PKNVEKALD 71
Cdd:cd19163   35 AIRT--VHEALDSGINYIDTAPWYGQgrsETVLGKALK------GIPRDSYYLATKvgryglDPDKMFDfsAERITKSVE 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  72 KTLADLKVDYIDLFYIHFPiafKFVPieekyppafycgdgdnfhYEDVPILETWKALEKLVASGKIRSIGVSNFPgallL 151
Cdd:cd19163  107 ESLKRLGLDYIDIIQVHDI---EFAP------------------SLDQILNETLPALQKLKEEGKVRFIGITGYP----L 161


                 ....
gi 461180628 152 DLLR 155
Cdd:cd19163  162 DVLK 165
AKR_PsAKR cd19091
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ...
 1-147 1.20e-10

Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.


Pssm-ID: 381317 [Multi-domain]  Cd Length: 319  Bit Score: 59.16  E-value: 1.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAADQVYQGIKAGYRLFDGAEDYGN-EKEI--GDGVKRAideglvtREEIFLTSKLWNNYHDPKN--------VEKA 69
Cdd:cd19091   37 DQEEADRLVDIALDAGINFFDTADVYSEgESEEilGKALKGR-------RDDVLIATKVRGRMGEGPNdvglsrhhIIRA 109

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 461180628  70 LDKTLADLKVDYIDLFYIHfpiAFkfvpieekyppafycgdgDNFhyedVPILETWKALEKLVASGKIRSIGVSNFPG 147
Cdd:cd19091  110 VEASLKRLGTDYIDLYQLH---GF------------------DAL----TPLEETLRALDDLVRQGKVRYIGVSNFSA 162
AKR_unchar cd19097
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 13-188 2.10e-10

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381323 [Multi-domain]  Cd Length: 267  Bit Score: 57.92  E-value: 2.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  13 IKAGYRLFDGAEDYGN-EKEIGdgvkraidEGLVTREEIFLTSKL----WNNYHDPKNVEKALDKTLADLKVDYIDLFYI 87
Cdd:cd19097   36 LKAGINTLDTAPAYGDsEKVLG--------KFLKRLDKFKIITKLpplkEDKKEDEAAIEASVEASLKRLKVDSLDGLLL 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  88 HFPIAFKfvpieekyppafycgdgdnFHYEDVpiletWKALEKLVASGKIRSIGVSNFPGALLLDLLrgATIKPAVLQVe 167
Cdd:cd19097  108 HNPDDLL-------------------KHGGKL-----VEALLELKKEGLIRKIGVSVYSPEELEKAL--ESFKIDIIQL- 160

                        170       180
                 ....*....|....*....|....*..
gi 461180628 168 hhPY------LQQPKLIEFAQKAGLIV 188
Cdd:cd19097  161 --PFnildqrFLKSGLLAKLKKKGIEI 185
AKR_Fe-S_oxidoreductase cd19096
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ...
 5-143 3.73e-10

Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381322 [Multi-domain]  Cd Length: 255  Bit Score: 57.19  E-value: 3.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   5 AADQVYQGIKAGYRLFDGAEDYGN---EKEIGDGVKRaideglVTREEIFLTSKL-WNNYHDPKNVEKALDKTLADLKVD 80
Cdd:cd19096   23 AIEMIRYAIDAGINYFDTAYGYGGgksEEILGEALKE------GPREKFYLATKLpPWSVKSAEDFRRILEESLKRLGVD 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 461180628  81 YIDLFYIHfpiafkfvpieekyppafycGDGDNFHYEDVPILETWKALEKLVASGKIRSIGVS 143
Cdd:cd19096   97 YIDFYLLH--------------------GLNSPEWLEKARKGGLLEFLEKAKKEGLIRHIGFS 139
AKR_AKR13D1 cd19145
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ...
 5-143 4.13e-10

AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381371 [Multi-domain]  Cd Length: 304  Bit Score: 57.44  E-value: 4.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   5 AADQVYQGIKAGYRLFDGAEDYG---NEKEIGDGVKRAIdeglvtREEIFLTSKLWNNY---------HDPKNVEKALDK 72
Cdd:cd19145   35 GIALIHHAFNSGVTFLDTSDIYGpntNEVLLGKALKDGP------REKVQLATKFGIHEiggsgvevrGDPAYVRAACEA 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 461180628  73 TLADLKVDYIDLFYIHfpiafkfvPIEEKyppafycgdgdnfhyedVPILETWKALEKLVASGKIRSIGVS 143
Cdd:cd19145  109 SLKRLDVDYIDLYYQH--------RIDTT-----------------VPIEITMGELKKLVEEGKIKYIGLS 154
PLN02587 PLN02587
L-galactose dehydrogenase
 1-146 4.73e-10

L-galactose dehydrogenase


Pssm-ID: 178198 [Multi-domain]  Cd Length: 314  Bit Score: 57.48  E-value: 4.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAAdqVYQGIKAGYRLFDGAEDYGN---EKEIGDGVKRAidegLVTREEIFLTSKLwNNYHD-----PKNVEKALDK 72
Cdd:PLN02587  31 EDAIAS--VREAFRLGINFFDTSPYYGGtlsEKVLGKALKAL----GIPREKYVVSTKC-GRYGEgfdfsAERVTKSVDE 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 461180628  73 TLADLKVDYIDLFYIHfpiafkfvPIEekyppafycgdgdnFHYEDVPILETWKALEKLVASGKIRSIGVSNFP 146
Cdd:PLN02587 104 SLARLQLDYVDILHCH--------DIE--------------FGSLDQIVNETIPALQKLKESGKVRFIGITGLP 155
AKR_galDH-like cd19153
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ...
 4-177 3.23e-09

L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381379 [Multi-domain]  Cd Length: 294  Bit Score: 54.85  E-value: 3.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   4 IAADQVYQGIKAGYRLFDGAEDYGN---EKEIGDGVKRAidegLVTREEIFLTSKLwNNYHDP------KNVEKALDKTL 74
Cdd:cd19153   34 EAVAIVAEAFAAGINHFDTSPYYGAessEAVLGKALAAL----QVPRSSYTVATKV-GRYRDSefdysaERVRASVATSL 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  75 ADLKVDYIDLFYIHfpiafkfvPIEekyppafycgdgdnFHYEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLL 154
Cdd:cd19153  109 ERLHTTYLDVVYLH--------DIE--------------FVDYDTLVDEALPALRTLKDEGVIKRIGIAGYPLDTLTRAT 166

                        170       180
                 ....*....|....*....|....
gi 461180628 155 RGATIKPA-VLQVEHHPYLQQPKL 177
Cdd:cd19153  167 RRCSPGSLdAVLSYCHLTLQDARL 190
AKR_unchar cd19101
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 15-145 2.92e-08

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381327 [Multi-domain]  Cd Length: 304  Bit Score: 52.21  E-value: 2.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  15 AGYRLFDGAEDYGNEKEI-GDGVKRAIDEGLVTREEIFLTsKL----WNNYHDPKNVEKALDKTLADLKVDYIDLFYihf 89
Cdd:cd19101   35 AGLTTFDCADIYGPAEELiGEFRKRLRRERDAADDVQIHT-KWvpdpGELTMTRAYVEAAIDRSLKRLGVDRLDLVQ--- 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 461180628  90 piafkfvpieekyppafycgdgdnFH---YEDVPILETWKALEKLVASGKIRSIGVSNF 145
Cdd:cd19101  111 ------------------------FHwwdYSDPGYLDAAKHLAELQEEGKIRHLGLTNF 145
AKR_AKR14A2 cd19151
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ...
 47-146 5.01e-07

Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).


Pssm-ID: 381377 [Multi-domain]  Cd Length: 309  Bit Score: 48.55  E-value: 5.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  47 REEIFLTSK----LWNN-YHD---PKNVEKALDKTLADLKVDYIDLFYIHFPIAfkfvpieekyppafycgdgdnfhyeD 118
Cdd:cd19151   76 RDELIISTKagytMWPGpYGDwgsKKYLIASLDQSLKRMGLDYVDIFYHHRPDP-------------------------E 130

                         90       100
                 ....*....|....*....|....*...
gi 461180628 119 VPILETWKALEKLVASGKIRSIGVSNFP 146
Cdd:cd19151  131 TPLEETMGALDQIVRQGKALYVGISNYP 158
AKR_AKR8A1-2 cd19077
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ...
 13-143 1.77e-06

AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).


Pssm-ID: 381303 [Multi-domain]  Cd Length: 302  Bit Score: 46.85  E-value: 1.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  13 IKAGYRLFDGAEDYG------NEKEIgdgvKRAIDEGLVTREEIFLTSKLWNNYH------DPKNVEKALDKTLADLK-V 79
Cdd:cd19077   35 LDAGSNLWNGGEFYGppdphaNLKLL----ARFFRKYPEYADKVVLSVKGGLDPDtlrpdgSPEAVRKSIENILRALGgT 110

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 461180628  80 DYIDLFYihfpiafkfvpieekyppafyCGDGDnfhyEDVPILETWKALEKLVASGKIRSIGVS 143
Cdd:cd19077  111 KKIDIFE---------------------PARVD----PNVPIEETIKALKELVKEGKIRGIGLS 149
AKR_AKR6C1_2 cd19143
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ...
 1-100 2.66e-06

AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381369 [Multi-domain]  Cd Length: 319  Bit Score: 46.44  E-value: 2.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAADQVYQGIKAGYRLFDGAEDYGN---EKEIGdgvkRAIDEGLVTREEIFLTSKL-WNNYHDPKN---------VE 67
Cdd:cd19143   29 DVDEAKECMKAAYDAGVNFFDNAEVYANgqsEEIMG----QAIKELGWPRSDYVVSTKIfWGGGGPPPNdrglsrkhiVE 104

                         90       100       110
                 ....*....|....*....|....*....|...
gi 461180628  68 kALDKTLADLKVDYIDLFYIHFPIAfkFVPIEE 100
Cdd:cd19143  105 -GTKASLKRLQLDYVDLVFCHRPDP--ATPIEE 134
AKR_FDH cd19162
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ...
 15-188 5.54e-06

D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.


Pssm-ID: 381388 [Multi-domain]  Cd Length: 290  Bit Score: 45.43  E-value: 5.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  15 AGYRLFDGAEDYG---NEKEIGDGVKRAideglvTREEIFLTSKLwNNYHDPKN-----------------VEKALDKTL 74
Cdd:cd19162   31 AGIRYFDTAPLYGlglSERRLGAALARH------PRAEYVVSTKV-GRLLEPGAagrpagadrrfdfsadgIRRSIEASL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  75 ADLKVDYIDLFYIHFPiafkfvpieekyppafycgDGDnfhyEDVPILETWKALEKLVASGKIRSIGVSNFPGALLLDLL 154
Cdd:cd19162  104 ERLGLDRLDLVFLHDP-------------------DRH----LLQALTDAFPALEELRAEGVVGAIGVGVTDWAALLRAA 160

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 461180628 155 RGATIKpAVLQVEHHPYLQQP---KLIEFAQKAGLIV 188
Cdd:cd19162  161 RRADVD-VVMVAGRYTLLDRRaatELLPLCAAKGVAV 196
AKR_AKR15A cd19152
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ...
 5-150 3.00e-05

AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.


Pssm-ID: 381378 [Multi-domain]  Cd Length: 308  Bit Score: 43.37  E-value: 3.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   5 AADQVYQGIKAGYRLFDGAEDYGN---EKEIGDGVKRAideglvTREEIFLTSKL------------------WNNY-HD 62
Cdd:cd19152   22 AKATLVAAWDLGIRYFDTAPWYGAglsEERLGAALREL------GREDYVISTKVgrllvplqeveptfepgfWNPLpFD 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  63 PKN------VEKALDKTLADLKVDYIDLFYIHFPiafkfvpieEKYppafYCGDGDNFHYEDVpILETWKALEKLVASGK 136
Cdd:cd19152   96 AVFdysydgILRSIEDSLQRLGLSRIDLLSIHDP---------DED----LAGAESDEHFAQA-IKGAFRALEELREEGV 161

                        170
                 ....*....|....*
gi 461180628 137 IRSIGV-SNFPGALL 150
Cdd:cd19152  162 IKAIGLgVNDWEVIL 176
AKR_AKR9A1-2 cd19146
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ...
 47-146 4.99e-05

Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.


Pssm-ID: 381372 [Multi-domain]  Cd Length: 326  Bit Score: 42.80  E-value: 4.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  47 REEIFLTSKLWNNY--HDP------------KNVEKALDKTLADLKVDYIDLFYIHFpiafkfvpieekyppafycgdgd 112
Cdd:cd19146   77 RDEMVLATKYTTGYrrGGPikiksnyqgnhaKSLRLSVEASLKKLQTSYIDILYVHW----------------------- 133

                         90       100       110
                 ....*....|....*....|....*....|....
gi 461180628 113 nFHYEdVPILETWKALEKLVASGKIRSIGVSNFP 146
Cdd:cd19146  134 -WDYT-TSIPELMQSLNHLVAAGKVLYLGVSDTP 165
AKR_AKR14A1 cd19150
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ...
 20-145 2.83e-04

Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.


Pssm-ID: 381376 [Multi-domain]  Cd Length: 309  Bit Score: 40.52  E-value: 2.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  20 FDGAEDYG-----NEKEIGdgvkRAIDEGLVT-REEIFLTSKL-WNNYHDP-------KNVEKALDKTLADLKVDYIDLF 85
Cdd:cd19150   47 FDLANNYGpppgsAEENFG----RILREDFAGyRDELIISTKAgYDMWPGPygewgsrKYLLASLDQSLKRMGLDYVDIF 122

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  86 YIHfpiafKFVPieekyppafycgdgdnfhyeDVPILETWKALEKLVASGKIRSIGVSNF 145
Cdd:cd19150  123 YSH-----RFDP--------------------DTPLEETMGALDHAVRSGKALYVGISSY 157
AKR_AKR15A1 cd19161
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ...
 1-141 2.18e-03

Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.


Pssm-ID: 381387 [Multi-domain]  Cd Length: 310  Bit Score: 37.69  E-value: 2.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628   1 DTAIAADQVyqGIKAGYRLFDGAEDYGN---EKEIGDGVKRaideglVTREEIFLTSK--------------LWNNYHDP 63
Cdd:cd19161   20 ADADATLDA--AWDSGIRYFDTAPMYGHglaEHRLGDFLRE------KPRDEFVLSTKvgrllkparegsvpDPNGFVDP 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 461180628  64 KNVEKALDKT-----------LADLKVDYIDLFYIHfpiafkfvPIEEkyppaFYCGDGDNFHYEDVPILETWKALEKLV 132
Cdd:cd19161   92 LPFEIVYDYSydgimrsfedsLQRLGLNRIDILYVH--------DIGV-----YTHGDRKERHHFAQLMSGGFKALEELK 158


                 ....*....
gi 461180628 133 ASGKIRSIG 141
Cdd:cd19161  159 KAGVIKAFG 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH