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Conserved domains on  [gi|507658585|gb|AGM61126|]
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GyrA, partial [Bacillus subtilis]

Protein Classification

DNA gyrase subunit A family protein( domain architecture ID 1000081)

DNA gyrase subunit A (GyrA) forms a 2:2 heterotetrameric complex with GyrB to form gyrase, a type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state; may be partial

CATH:  1.10.268.10|3.90.199.10
PubMed:  11395412|9519293|17397985

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05560 super family cl35335
DNA gyrase subunit A; Validated
 1-187 1.06e-154

DNA gyrase subunit A; Validated


The actual alignment was detected with superfamily member PRK05560:

Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 446.78  E-value: 1.06e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585   1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIS 80
Cdd:PRK05560  49 MNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIA 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585  81 MEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDVTIPKLMEV 160
Cdd:PRK05560 129 HELLADIDKETVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACLALIDNPDITIEELMEI 208

                        170       180
                 ....*....|....*....|....*..
gi 507658585 161 IPGPDFPTAGQILGRSGIRKAYESGRG 187
Cdd:PRK05560 209 IPGPDFPTGGIILGRSGIREAYRTGRG 235
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 1-187 1.06e-154

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 446.78  E-value: 1.06e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585   1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIS 80
Cdd:PRK05560  49 MNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIA 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585  81 MEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDVTIPKLMEV 160
Cdd:PRK05560 129 HELLADIDKETVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACLALIDNPDITIEELMEI 208

                        170       180
                 ....*....|....*....|....*..
gi 507658585 161 IPGPDFPTAGQILGRSGIRKAYESGRG 187
Cdd:PRK05560 209 IPGPDFPTGGIILGRSGIREAYRTGRG 235
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-187 9.14e-151

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 436.78  E-value: 9.14e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585   1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIS 80
Cdd:COG0188   54 MHELGLTPDKPYKKSARVVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARLAKIA 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585  81 MEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDVTIPKLMEV 160
Cdd:COG0188  134 EELLADIDKDTVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACIALIDNPDATIEELMEY 213

                        170       180
                 ....*....|....*....|....*..
gi 507658585 161 IPGPDFPTAGQILGRSGIRKAYESGRG 187
Cdd:COG0188  214 IPGPDFPTGGIIVGREGIREAYETGRG 240
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 1-187 2.26e-135

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 397.07  E-value: 2.26e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585    1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIS 80
Cdd:TIGR01063  45 MYELGLTPDKPYKKSARIVGDVMGKYHPHGDSAIYDTLVRMAQDFSLRYPLVDGQGNFGSIDGDPPAAMRYTEARLTKIA 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585   81 MEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDVTIPKLMEV 160
Cdd:TIGR01063 125 EELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLLVNGSSGIAVGMATNIPPHNLGEIIDALLAYIDNPDISIQELLEV 204

                         170       180
                  ....*....|....*....|....*..
gi 507658585  161 IPGPDFPTAGQILGRSGIRKAYESGRG 187
Cdd:TIGR01063 205 IKGPDFPTGGIILGRSGIRSAYETGRG 231
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 1-187 3.05e-123

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 354.95  E-value: 3.05e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585   1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIS 80
Cdd:cd00187   23 MFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNFGSRDGDDAAAMRYTETRLSPIA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585  81 MEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDVTIPKLMEV 160
Cdd:cd00187  103 RLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLREVIDALRALIDNPEASIDELMEI 182

                        170       180
                 ....*....|....*....|....*..
gi 507658585 161 IPGPDFPTAGQILGRSGIRKAYESGRG 187
Cdd:cd00187  183 IKGPDFPTGGIIEGRAGIREAYETGRG 209
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 1-179 4.76e-111

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 323.75  E-value: 4.76e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585     1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV-DGDSAAAMRYTEARMSKI 79
Cdd:smart00434  42 MFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIVRMAQDFSNNYPLLDGQGNFGSRlDGDDAAAMRYTETRLSPL 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585    80 SMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDVTIPKLME 159
Cdd:smart00434 122 ARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVNGSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASIDELMM 201

                          170       180
                   ....*....|....*....|
gi 507658585   160 VIPGPDFPTAGQILGRSGIR 179
Cdd:smart00434 202 IPWGPDFPTGGEIVGPGKYV 221
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
1-187 1.53e-110

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 322.19  E-value: 1.53e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585    1 MNDLgMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV-DGDSAAAMRYTEARMSKI 79
Cdd:pfam00521  21 MFEL-LNLDKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGSRiDGDKDAAMRYTETRLSKI 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585   80 SMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDVTIpkLME 159
Cdd:pfam00521 100 ARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREIIDALIALLDGPEATL--LMK 177

                         170       180
                  ....*....|....*....|....*...
gi 507658585  160 VIPGPDFPTAGQILGRSGIRKAYESGRG 187
Cdd:pfam00521 178 YIMGPDFPTGGGIIGKGGIKEAYKTGRG 205
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 1-187 1.06e-154

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 446.78  E-value: 1.06e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585   1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIS 80
Cdd:PRK05560  49 MNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIA 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585  81 MEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDVTIPKLMEV 160
Cdd:PRK05560 129 HELLADIDKETVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACLALIDNPDITIEELMEI 208

                        170       180
                 ....*....|....*....|....*..
gi 507658585 161 IPGPDFPTAGQILGRSGIRKAYESGRG 187
Cdd:PRK05560 209 IPGPDFPTGGIILGRSGIREAYRTGRG 235
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-187 9.14e-151

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 436.78  E-value: 9.14e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585   1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIS 80
Cdd:COG0188   54 MHELGLTPDKPYKKSARVVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARLAKIA 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585  81 MEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDVTIPKLMEV 160
Cdd:COG0188  134 EELLADIDKDTVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACIALIDNPDATIEELMEY 213

                        170       180
                 ....*....|....*....|....*..
gi 507658585 161 IPGPDFPTAGQILGRSGIRKAYESGRG 187
Cdd:COG0188  214 IPGPDFPTGGIIVGREGIREAYETGRG 240
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 1-187 2.26e-135

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 397.07  E-value: 2.26e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585    1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIS 80
Cdd:TIGR01063  45 MYELGLTPDKPYKKSARIVGDVMGKYHPHGDSAIYDTLVRMAQDFSLRYPLVDGQGNFGSIDGDPPAAMRYTEARLTKIA 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585   81 MEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDVTIPKLMEV 160
Cdd:TIGR01063 125 EELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLLVNGSSGIAVGMATNIPPHNLGEIIDALLAYIDNPDISIQELLEV 204

                         170       180
                  ....*....|....*....|....*..
gi 507658585  161 IPGPDFPTAGQILGRSGIRKAYESGRG 187
Cdd:TIGR01063 205 IKGPDFPTGGIILGRSGIRSAYETGRG 231
PRK05561 PRK05561
DNA topoisomerase 4 subunit A;
1-187 1.70e-131

DNA topoisomerase 4 subunit A;


Pssm-ID: 235503 [Multi-domain]  Cd Length: 742  Bit Score: 385.61  E-value: 1.70e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585   1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIS 80
Cdd:PRK05561  54 MSELGLTPDAKFKKSARVVGDVLGKYHPHGDSSIYDAMVRMAQDFSYRYPLVDGQGNFGSIDGDPAAAMRYTEARLSPIA 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585  81 MEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDVTIPKLMEV 160
Cdd:PRK05561 134 ELLLEEIDEGTVDFVPNFDGTLKEPTVLPARFPNLLLNGATGIAVGMATDIPPHNLREVIDAAIHLIDNPDATLEELMEF 213

                        170       180
                 ....*....|....*....|....*...
gi 507658585 161 IPGPDFPTAGQIL-GRSGIRKAYESGRG 187
Cdd:PRK05561 214 VPGPDFPTGGEIItGRDGIRKAYETGRG 241
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 1-187 3.05e-123

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 354.95  E-value: 3.05e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585   1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIS 80
Cdd:cd00187   23 MFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNFGSRDGDDAAAMRYTETRLSPIA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585  81 MEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDVTIPKLMEV 160
Cdd:cd00187  103 RLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLREVIDALRALIDNPEASIDELMEI 182

                        170       180
                 ....*....|....*....|....*..
gi 507658585 161 IPGPDFPTAGQILGRSGIRKAYESGRG 187
Cdd:cd00187  183 IKGPDFPTGGIIEGRAGIREAYETGRG 209
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 1-179 4.76e-111

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 323.75  E-value: 4.76e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585     1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV-DGDSAAAMRYTEARMSKI 79
Cdd:smart00434  42 MFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIVRMAQDFSNNYPLLDGQGNFGSRlDGDDAAAMRYTETRLSPL 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585    80 SMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDVTIPKLME 159
Cdd:smart00434 122 ARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVNGSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASIDELMM 201

                          170       180
                   ....*....|....*....|
gi 507658585   160 VIPGPDFPTAGQILGRSGIR 179
Cdd:smart00434 202 IPWGPDFPTGGEIVGPGKYV 221
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
1-187 1.53e-110

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 322.19  E-value: 1.53e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585    1 MNDLgMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV-DGDSAAAMRYTEARMSKI 79
Cdd:pfam00521  21 MFEL-LNLDKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGSRiDGDKDAAMRYTETRLSKI 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585   80 SMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDVTIpkLME 159
Cdd:pfam00521 100 ARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREIIDALIALLDGPEATL--LMK 177

                         170       180
                  ....*....|....*....|....*...
gi 507658585  160 VIPGPDFPTAGQILGRSGIRKAYESGRG 187
Cdd:pfam00521 178 YIMGPDFPTGGGIIGKGGIKEAYKTGRG 205
PRK13979 PRK13979
DNA topoisomerase IV subunit A; Provisional
 9-187 1.09e-101

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 237576 [Multi-domain]  Cd Length: 957  Bit Score: 313.58  E-value: 1.09e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585   9 DKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDIT 88
Cdd:PRK13979  65 DKPYYKSARIVGDILGKYHPHGDSSVYDAMVILAQDFTTRMPLIDGHGNWGSIDGDSAAAMRYTEARLTPIAMEMLRDID 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585  89 KDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDVTIPKLMEVIPGPDFPT 168
Cdd:PRK13979 145 KDVVNMVDNYSDSEKEPEVLPARYPNLLVNGAFGIAVGLATNIPPHNLKEVIDGTLAYIDNNEITTKELMNYIKGPDLPT 224

                        170
                 ....*....|....*....
gi 507658585 169 AGQILGRSGIRKAYESGRG 187
Cdd:PRK13979 225 GGILIGKKSLLSAYETGEG 243
parC_Gpos TIGR01061
DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II ...
 1-187 2.57e-93

DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273422 [Multi-domain]  Cd Length: 738  Bit Score: 286.70  E-value: 2.57e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585    1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIS 80
Cdd:TIGR01061  45 MFQDGNTFDKPYKKSARTVGEIMGKYHPHGDSSIYDAMVRMSQDWKNNWTLVEMHGNNGSIDGDNAAAMRYTEARLSLIA 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585   81 MEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDVTIPKLMEV 160
Cdd:TIGR01061 125 SELLKDIDKKTVSFIPNFDDSEKEPTVLPALFPNLLINGATGIAAGYATNIPPHNLNEVIDALIYRIDHPNCSVDKLMEI 204

                         170       180
                  ....*....|....*....|....*..
gi 507658585  161 IPGPDFPTAGQILGRSGIRKAYESGRG 187
Cdd:TIGR01061 205 VKGPDFPTGGIIQGEDGISKAYETGKG 231
parC_Gneg TIGR01062
DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II ...
 1-187 4.04e-90

DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 130134 [Multi-domain]  Cd Length: 735  Bit Score: 278.33  E-value: 4.04e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585    1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDG-DSAAAMRYTEARMSKI 79
Cdd:TIGR01062  45 MSELGLNANAKYKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDpKSFAAMRYTESRLSKI 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585   80 SMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDVTIPKLME 159
Cdd:TIGR01062 125 SELLLEELGQGTVDFRPNFDGTLLEPVILPARLPNILLNGTTGIAVGMATDIPPHNLHELADAALYLIDNPKAGLDDILN 204

                         170       180
                  ....*....|....*....|....*....
gi 507658585  160 VIPGPDFPTAGQILG-RSGIRKAYESGRG 187
Cdd:TIGR01062 205 IVQGPDFPTEAEIIDkAEEIRKIYETGRG 233
PRK09631 PRK09631
DNA topoisomerase IV subunit A; Provisional
 9-187 8.85e-42

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 236598 [Multi-domain]  Cd Length: 635  Bit Score: 147.93  E-value: 8.85e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585   9 DKPYKKSARIVGEVIgKYHPHGDSAVYESMVRMA-QDFnyrymLVDGHGNFGSV-DGDSAAAMRYTEARMSKISMEIL-- 84
Cdd:PRK09631  48 DGKFHKVANVVGNTM-KYHPHGDASIYEALVNLAnKDL-----FIDKQGNFGNLfTGDPASAARYIECRLTPLAKEVLyn 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585  85 RDITkdtiDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDVTIPklmevipgP 164
Cdd:PRK09631 122 KEIT----EYEPSYDGRNNEPLCLPAKIPVILIQGAEGIAVGMATKILPHNFNEILQAVKSELLGESFALY--------P 189

                        170       180
                 ....*....|....*....|...
gi 507658585 165 DFPTAGqILGRSGirkaYESGRG 187
Cdd:PRK09631 190 DFPTGG-IVDVSE----YADGNG 207
PRK12758 PRK12758
DNA gyrase/topoisomerase IV subunit A;
9-172 2.13e-40

DNA gyrase/topoisomerase IV subunit A;


Pssm-ID: 237192 [Multi-domain]  Cd Length: 869  Bit Score: 145.15  E-value: 2.13e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585   9 DKPYKKSARIVGEVIgKYHPHGDSAVYESMVRMAQdfnyRYMLVDGHGNFGSV-DGDSAAAMRYTEARMSKISMEILrdI 87
Cdd:PRK12758  67 DGRYNKVANVVGHTM-QYHPHGDASIGDALVQLGQ----KDLLIDTQGNWGNIlTGDGAAAPRYIEARLSKFALEVV--F 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585  88 TKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDVTIPklmevipgPDFP 167
Cdd:PRK12758 140 NPKTTEWQLSYDGRKKEPVTLPVKFPLLLAQGAEGIAVGLSTKILPHNFNELIDASIAYLKGKEFKLY--------PDFP 211


                 ....*
gi 507658585 168 TAGQI 172
Cdd:PRK12758 212 TGGII 216
PRK09630 PRK09630
DNA topoisomerase IV subunit A; Provisional
 9-170 1.21e-32

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 170022  Cd Length: 479  Bit Score: 121.54  E-value: 1.21e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585   9 DKPYKKSARIVGEVIGkYHPHGDSAVYESMVRMAqdfNYRYmLVDGHGNFGS-VDGDSAAAMRYTEARMSKISMEILrdI 87
Cdd:PRK09630  48 DGKMHKVANIAGRTMA-LHPHGDAPIVEALVVLA---NKGY-LIDTQGNFGNpLTGDPHAAARYIEARLSPLAKEVL--F 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585  88 TKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDVTIPklmevipgPDFP 167
Cdd:PRK09630 121 NTDLMTFHDSYDGREKEPDILPAKLPLLLLHGVDGIAVGMTTKIFPHNFCELLEAQIAILNDQPFTLL--------PDFP 192


                 ...
gi 507658585 168 TAG 170
Cdd:PRK09630 193 SGG 195
52 PHA02592
DNA topisomerase II medium subunit; Provisional
 12-183 3.02e-23

DNA topisomerase II medium subunit; Provisional


Pssm-ID: 222896 [Multi-domain]  Cd Length: 439  Bit Score: 95.12  E-value: 3.02e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585  12 YKKSARIVGEV--IGkYHpHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSkismEILRDITK 89
Cdd:PHA02592  58 FDKVAAIAGGVadLG-YH-HGETSAQDAGALMANTWNNNIPLLDGQGNFGSRLVQKAAAARYIFARVH----DNFRKIYK 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585  90 DtIDYQDNYDGSERepvvMPSRF-----PNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDVTIPKlmevipgP 164
Cdd:PHA02592 132 D-EDLAPVHEDPEH----IPPAFylpiiPMVLLNGVSGIATGYATNILPHSPKSVIKAVLAALNGKDITEPK-------V 199

                        170       180
                 ....*....|....*....|....
gi 507658585 165 DFPT-AGQIL----GRSGIRKAYE 183
Cdd:PHA02592 200 QFPEfKGEVVeiepGSYEIRGTYE 223
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 26-143 4.30e-15

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 72.39  E-value: 4.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585   26 YHpHGDSAVYESMVRMAQDF----NYRYMLVDGHgnFGS--VDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNyD 99
Cdd:PTZ00108  724 YH-HGEQSLQQTIVGMAQNFvgsnNINLLYPCGQ--FGSrlQGGKDHAAARYIFTKLSKITRYIFPEEDDPILDYLED-D 799

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 507658585  100 GSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGV 143
Cdd:PTZ00108  800 GQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNL 843
PLN03128 PLN03128
DNA topoisomerase 2; Provisional
 26-140 1.74e-11

DNA topoisomerase 2; Provisional


Pssm-ID: 215593 [Multi-domain]  Cd Length: 1135  Bit Score: 62.03  E-value: 1.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585   26 YHpHGDSAVYESMVRMAQDF---NYRYMLVDgHGNFGS--VDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNyDG 100
Cdd:PLN03128  717 YH-HGEASLASTIIGMAQDFvgsNNINLLTP-SGQFGTrlQGGKDAASARYIFTRLSPITRALFPKDDDVLLNYLNE-DG 793

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 507658585  101 SEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEII 140
Cdd:PLN03128  794 QSIEPEWYCPIIPMVLVNGSEGIGTGWSTFIPNYNPRDII 833
PLN03237 PLN03237
DNA topoisomerase 2; Provisional
 14-143 7.70e-11

DNA topoisomerase 2; Provisional


Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 60.26  E-value: 7.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658585   14 KSARIVGEV--IGKYHpHGDSAVYESMVRMAQDF---NYRYMLVDGhGNFG--SVDGDSAAAMRYTEARMSKISMEILRD 86
Cdd:PLN03237  728 KVAQLSGYVseHSAYH-HGEQSLASTIIGMAQDFvgsNNINLLLPN-GQFGtrLQGGKDHASARYIFTRLSPITRFLFPK 805

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 507658585   87 ITKDTIDYQDNyDGSEREPV-VMPSrFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGV 143
Cdd:PLN03237  806 DDDILLDYLNE-DGQSIEPTwYMPI-IPTVLVNGAEGIGTGWSTFIPNYNPRDIVANI 861
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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