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Conserved domains on  [gi|507658591|gb|AGM61129|]
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GyrA, partial [Bacillus subtilis]

Protein Classification

DNA gyrase subunit A family protein( domain architecture ID 1000081)

DNA gyrase subunit A (GyrA) forms a 2:2 heterotetrameric complex with GyrB to form gyrase, a type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state; may be partial

CATH:  1.10.268.10|3.90.199.10
PubMed:  11395412|9519293|17397985

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05560 super family cl35335
DNA gyrase subunit A; Validated
 1-214 5.61e-174

DNA gyrase subunit A; Validated


The actual alignment was detected with superfamily member PRK05560:

Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 497.24  E-value: 5.61e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591   1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIS 80
Cdd:PRK05560  49 MNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIA 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591  81 MEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEV 160
Cdd:PRK05560 129 HELLADIDKETVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACLALIDNPDITIEELMEI 208

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 507658591 161 IPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTsSGKERIIVTELPY 214
Cdd:PRK05560 209 IPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKAEIEEI-KGREAIIVTEIPY 261
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 1-214 5.61e-174

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 497.24  E-value: 5.61e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591   1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIS 80
Cdd:PRK05560  49 MNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIA 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591  81 MEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEV 160
Cdd:PRK05560 129 HELLADIDKETVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACLALIDNPDITIEELMEI 208

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 507658591 161 IPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTsSGKERIIVTELPY 214
Cdd:PRK05560 209 IPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKAEIEEI-KGREAIIVTEIPY 261
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-214 8.37e-171

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 489.17  E-value: 8.37e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591   1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIS 80
Cdd:COG0188   54 MHELGLTPDKPYKKSARVVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARLAKIA 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591  81 MEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEV 160
Cdd:COG0188  134 EELLADIDKDTVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACIALIDNPDATIEELMEY 213

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 507658591 161 IPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPY 214
Cdd:COG0188  214 IPGPDFPTGGIIVGREGIREAYETGRGSIRVRAKAEIEELKRGREQIVVTEIPY 267
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 1-214 2.40e-153

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 444.44  E-value: 2.40e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591    1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIS 80
Cdd:TIGR01063  45 MYELGLTPDKPYKKSARIVGDVMGKYHPHGDSAIYDTLVRMAQDFSLRYPLVDGQGNFGSIDGDPPAAMRYTEARLTKIA 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591   81 MEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEV 160
Cdd:TIGR01063 125 EELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLLVNGSSGIAVGMATNIPPHNLGEIIDALLAYIDNPDISIQELLEV 204

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 507658591  161 IPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPY 214
Cdd:TIGR01063 205 IKGPDFPTGGIILGRSGIRSAYETGRGSIVIRARAEIEEDSKGREAIIVTEIPY 258
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 1-214 1.12e-136

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 390.00  E-value: 1.12e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591   1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIS 80
Cdd:cd00187   23 MFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNFGSRDGDDAAAMRYTETRLSPIA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591  81 MEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEV 160
Cdd:cd00187  103 RLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLREVIDALRALIDNPEASIDELMEI 182

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 507658591 161 IPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEqTSSGKERIIVTELPY 214
Cdd:cd00187  183 IKGPDFPTGGIIEGRAGIREAYETGRGRYIIRGKYEIE-DDEGRNTIEITELPY 235
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
1-214 1.82e-121

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 351.08  E-value: 1.82e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591    1 MNDLgMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV-DGDSAAAMRYTEARMSKI 79
Cdd:pfam00521  21 MFEL-LNLDKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGSRiDGDKDAAMRYTETRLSKI 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591   80 SMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIpeLME 159
Cdd:pfam00521 100 ARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREIIDALIALLDGPEATL--LMK 177

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 507658591  160 VIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQtssgKERIIVTELPY 214
Cdd:pfam00521 178 YIMGPDFPTGGGIIGKGGIKEAYKTGRGKITVRAKVEIED----RKTIVITELPY 228
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 1-214 1.76e-117

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 341.47  E-value: 1.76e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591     1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV-DGDSAAAMRYTEARMSKI 79
Cdd:smart00434  42 MFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIVRMAQDFSNNYPLLDGQGNFGSRlDGDDAAAMRYTETRLSPL 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591    80 SMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELME 159
Cdd:smart00434 122 ARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVNGSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASIDELMM 201

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 507658591   160 VIPGPDFPTAGQILGRSgirkayesgrgSITIRAKAEIEqtssGKERIIVTELPY 214
Cdd:smart00434 202 IPWGPDFPTGGEIVGPG-----------KYVVRGKIEIE----DDNTIVITELPY 241
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 1-214 5.61e-174

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 497.24  E-value: 5.61e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591   1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIS 80
Cdd:PRK05560  49 MNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIA 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591  81 MEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEV 160
Cdd:PRK05560 129 HELLADIDKETVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACLALIDNPDITIEELMEI 208

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 507658591 161 IPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTsSGKERIIVTELPY 214
Cdd:PRK05560 209 IPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKAEIEEI-KGREAIIVTEIPY 261
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-214 8.37e-171

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 489.17  E-value: 8.37e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591   1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIS 80
Cdd:COG0188   54 MHELGLTPDKPYKKSARVVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARLAKIA 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591  81 MEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEV 160
Cdd:COG0188  134 EELLADIDKDTVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACIALIDNPDATIEELMEY 213

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 507658591 161 IPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPY 214
Cdd:COG0188  214 IPGPDFPTGGIIVGREGIREAYETGRGSIRVRAKAEIEELKRGREQIVVTEIPY 267
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 1-214 2.40e-153

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 444.44  E-value: 2.40e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591    1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIS 80
Cdd:TIGR01063  45 MYELGLTPDKPYKKSARIVGDVMGKYHPHGDSAIYDTLVRMAQDFSLRYPLVDGQGNFGSIDGDPPAAMRYTEARLTKIA 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591   81 MEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEV 160
Cdd:TIGR01063 125 EELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLLVNGSSGIAVGMATNIPPHNLGEIIDALLAYIDNPDISIQELLEV 204

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 507658591  161 IPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPY 214
Cdd:TIGR01063 205 IKGPDFPTGGIILGRSGIRSAYETGRGSIVIRARAEIEEDSKGREAIIVTEIPY 258
PRK05561 PRK05561
DNA topoisomerase 4 subunit A;
1-214 1.44e-147

DNA topoisomerase 4 subunit A;


Pssm-ID: 235503 [Multi-domain]  Cd Length: 742  Bit Score: 427.99  E-value: 1.44e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591   1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIS 80
Cdd:PRK05561  54 MSELGLTPDAKFKKSARVVGDVLGKYHPHGDSSIYDAMVRMAQDFSYRYPLVDGQGNFGSIDGDPAAAMRYTEARLSPIA 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591  81 MEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEV 160
Cdd:PRK05561 134 ELLLEEIDEGTVDFVPNFDGTLKEPTVLPARFPNLLLNGATGIAVGMATDIPPHNLREVIDAAIHLIDNPDATLEELMEF 213

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 507658591 161 IPGPDFPTAGQIL-GRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPY 214
Cdd:PRK05561 214 VPGPDFPTGGEIItGRDGIRKAYETGRGSIRVRARWEIEDLAGGRWQIVITELPY 268
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 1-214 1.12e-136

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 390.00  E-value: 1.12e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591   1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIS 80
Cdd:cd00187   23 MFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNFGSRDGDDAAAMRYTETRLSPIA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591  81 MEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEV 160
Cdd:cd00187  103 RLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLREVIDALRALIDNPEASIDELMEI 182

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 507658591 161 IPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEqTSSGKERIIVTELPY 214
Cdd:cd00187  183 IKGPDFPTGGIIEGRAGIREAYETGRGRYIIRGKYEIE-DDEGRNTIEITELPY 235
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
1-214 1.82e-121

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 351.08  E-value: 1.82e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591    1 MNDLgMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV-DGDSAAAMRYTEARMSKI 79
Cdd:pfam00521  21 MFEL-LNLDKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGSRiDGDKDAAMRYTETRLSKI 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591   80 SMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIpeLME 159
Cdd:pfam00521 100 ARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREIIDALIALLDGPEATL--LMK 177

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 507658591  160 VIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQtssgKERIIVTELPY 214
Cdd:pfam00521 178 YIMGPDFPTGGGIIGKGGIKEAYKTGRGKITVRAKVEIED----RKTIVITELPY 228
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 1-214 1.76e-117

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 341.47  E-value: 1.76e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591     1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV-DGDSAAAMRYTEARMSKI 79
Cdd:smart00434  42 MFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIVRMAQDFSNNYPLLDGQGNFGSRlDGDDAAAMRYTETRLSPL 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591    80 SMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELME 159
Cdd:smart00434 122 ARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVNGSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASIDELMM 201

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 507658591   160 VIPGPDFPTAGQILGRSgirkayesgrgSITIRAKAEIEqtssGKERIIVTELPY 214
Cdd:smart00434 202 IPWGPDFPTGGEIVGPG-----------KYVVRGKIEIE----DDNTIVITELPY 241
PRK13979 PRK13979
DNA topoisomerase IV subunit A; Provisional
 9-214 5.05e-112

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 237576 [Multi-domain]  Cd Length: 957  Bit Score: 341.70  E-value: 5.05e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591   9 DKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDIT 88
Cdd:PRK13979  65 DKPYYKSARIVGDILGKYHPHGDSSVYDAMVILAQDFTTRMPLIDGHGNWGSIDGDSAAAMRYTEARLTPIAMEMLRDID 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591  89 KDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDFPT 168
Cdd:PRK13979 145 KDVVNMVDNYSDSEKEPEVLPARYPNLLVNGAFGIAVGLATNIPPHNLKEVIDGTLAYIDNNEITTKELMNYIKGPDLPT 224

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 507658591 169 AGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPY 214
Cdd:PRK13979 225 GGILIGKKSLLSAYETGEGKVTLRAKTKIEKLENGRLGIVITEFPY 270
parC_Gpos TIGR01061
DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II ...
 1-214 3.30e-103

DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273422 [Multi-domain]  Cd Length: 738  Bit Score: 313.66  E-value: 3.30e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591    1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKIS 80
Cdd:TIGR01061  45 MFQDGNTFDKPYKKSARTVGEIMGKYHPHGDSSIYDAMVRMSQDWKNNWTLVEMHGNNGSIDGDNAAAMRYTEARLSLIA 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591   81 MEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEV 160
Cdd:TIGR01061 125 SELLKDIDKKTVSFIPNFDDSEKEPTVLPALFPNLLINGATGIAAGYATNIPPHNLNEVIDALIYRIDHPNCSVDKLMEI 204

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 507658591  161 IPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPY 214
Cdd:TIGR01061 205 VKGPDFPTGGIIQGEDGISKAYETGKGKFIIRAKIEIEVNKNGLNQIVITEIPY 258
parC_Gneg TIGR01062
DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II ...
 1-214 5.00e-95

DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 130134 [Multi-domain]  Cd Length: 735  Bit Score: 292.58  E-value: 5.00e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591    1 MNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDG-DSAAAMRYTEARMSKI 79
Cdd:TIGR01062  45 MSELGLNANAKYKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDpKSFAAMRYTESRLSKI 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591   80 SMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELME 159
Cdd:TIGR01062 125 SELLLEELGQGTVDFRPNFDGTLLEPVILPARLPNILLNGTTGIAVGMATDIPPHNLHELADAALYLIDNPKAGLDDILN 204

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 507658591  160 VIPGPDFPTAGQILG-RSGIRKAYESGRGSITIRAKAEIEQTSsgkerIIVTELPY 214
Cdd:TIGR01062 205 IVQGPDFPTEAEIIDkAEEIRKIYETGRGSFRMRARWKKEDGQ-----IVISALPH 255
PRK09631 PRK09631
DNA topoisomerase IV subunit A; Provisional
 9-214 7.81e-47

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 236598 [Multi-domain]  Cd Length: 635  Bit Score: 162.95  E-value: 7.81e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591   9 DKPYKKSARIVGEVIgKYHPHGDSAVYESMVRMA-QDFnyrymLVDGHGNFGSV-DGDSAAAMRYTEARMSKISMEIL-- 84
Cdd:PRK09631  48 DGKFHKVANVVGNTM-KYHPHGDASIYEALVNLAnKDL-----FIDKQGNFGNLfTGDPASAARYIECRLTPLAKEVLyn 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591  85 RDITkdtiDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPelmevipgP 164
Cdd:PRK09631 122 KEIT----EYEPSYDGRNNEPLCLPAKIPVILIQGAEGIAVGMATKILPHNFNEILQAVKSELLGESFALY--------P 189

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 507658591 165 DFPTAGqILGRSGirkaYESGRGSITIRAKAEIeqtsSGKERIIVTELPY 214
Cdd:PRK09631 190 DFPTGG-IVDVSE----YADGNGKVLVRAKIET----KDEKTIVIREIPF 230
PRK12758 PRK12758
DNA gyrase/topoisomerase IV subunit A;
9-214 2.92e-42

DNA gyrase/topoisomerase IV subunit A;


Pssm-ID: 237192 [Multi-domain]  Cd Length: 869  Bit Score: 151.70  E-value: 2.92e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591   9 DKPYKKSARIVGEVIgKYHPHGDSAVYESMVRMAQdfnyRYMLVDGHGNFGSV-DGDSAAAMRYTEARMSKISMEILrdI 87
Cdd:PRK12758  67 DGRYNKVANVVGHTM-QYHPHGDASIGDALVQLGQ----KDLLIDTQGNWGNIlTGDGAAAPRYIEARLSKFALEVV--F 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591  88 TKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPelmevipgPDFP 167
Cdd:PRK12758 140 NPKTTEWQLSYDGRKKEPVTLPVKFPLLLAQGAEGIAVGLSTKILPHNFNELIDASIAYLKGKEFKLY--------PDFP 211

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 507658591 168 TAGqILGRSgirkAYESGR--GSITIRAKaeIEQTSsgKERIIVTELPY 214
Cdd:PRK12758 212 TGG-IIDVS----NYNDGErgGRVRVRAK--IEKLD--KKTLVITEIPY 251
PRK09630 PRK09630
DNA topoisomerase IV subunit A; Provisional
 9-197 2.06e-36

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 170022  Cd Length: 479  Bit Score: 132.71  E-value: 2.06e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591   9 DKPYKKSARIVGEVIGkYHPHGDSAVYESMVRMAqdfNYRYmLVDGHGNFGS-VDGDSAAAMRYTEARMSKISMEILrdI 87
Cdd:PRK09630  48 DGKMHKVANIAGRTMA-LHPHGDAPIVEALVVLA---NKGY-LIDTQGNFGNpLTGDPHAAARYIEARLSPLAKEVL--F 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591  88 TKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPelmevipgPDFP 167
Cdd:PRK09630 121 NTDLMTFHDSYDGREKEPDILPAKLPLLLLHGVDGIAVGMTTKIFPHNFCELLEAQIAILNDQPFTLL--------PDFP 192

                        170       180       190
                 ....*....|....*....|....*....|
gi 507658591 168 TAGQILGRSgirkaYESGRGSITIRAKAEI 197
Cdd:PRK09630 193 SGGTMDASE-----YQDGLGSITLRASIDI 217
52 PHA02592
DNA topisomerase II medium subunit; Provisional
 12-214 4.52e-26

DNA topisomerase II medium subunit; Provisional


Pssm-ID: 222896 [Multi-domain]  Cd Length: 439  Bit Score: 103.98  E-value: 4.52e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591  12 YKKSARIVGEV--IGkYHpHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSkismEILRDITK 89
Cdd:PHA02592  58 FDKVAAIAGGVadLG-YH-HGETSAQDAGALMANTWNNNIPLLDGQGNFGSRLVQKAAAARYIFARVH----DNFRKIYK 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591  90 DtIDYQDNYDGSERepvvMPSRF-----PNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPElmevipgP 164
Cdd:PHA02592 132 D-EDLAPVHEDPEH----IPPAFylpiiPMVLLNGVSGIATGYATNILPHSPKSVIKAVLAALNGKDITEPK-------V 199

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 507658591 165 DFPT-AGQILgrsgirkayESGRGSITIRAKAEIeqtsSGKERIIVTELPY 214
Cdd:PHA02592 200 QFPEfKGEVV---------EIEPGSYEIRGTYEL----NGKTKLHITEIPV 237
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 26-213 1.28e-14

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 72.00  E-value: 1.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591   26 YHpHGDSAVYESMVRMAQDF----NYRYMLVDGHgnFGS--VDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNyD 99
Cdd:PTZ00108  724 YH-HGEQSLQQTIVGMAQNFvgsnNINLLYPCGQ--FGSrlQGGKDHAAARYIFTKLSKITRYIFPEEDDPILDYLED-D 799

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591  100 GSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENpditiPELMEVIPgpdfptagqilgrsgir 179
Cdd:PTZ00108  800 GQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNLRRRLNG-----EEVRPLVP----------------- 857

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 507658591  180 kAYESGRGSITIRAKAEIEqtSSGK------ERIIVTELP 213
Cdd:PTZ00108  858 -WYRGFKGTIERNPKGKFI--SKGIyekvpdGTVEITELP 894
PLN03128 PLN03128
DNA topoisomerase 2; Provisional
 26-213 2.78e-13

DNA topoisomerase 2; Provisional


Pssm-ID: 215593 [Multi-domain]  Cd Length: 1135  Bit Score: 68.20  E-value: 2.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591   26 YHpHGDSAVYESMVRMAQDF---NYRYMLVDgHGNFGS--VDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNyDG 100
Cdd:PLN03128  717 YH-HGEASLASTIIGMAQDFvgsNNINLLTP-SGQFGTrlQGGKDAASARYIFTRLSPITRALFPKDDDVLLNYLNE-DG 793

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591  101 SEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDitiPELMEvipgpdfPTAGQILGRsgIRK 180
Cdd:PLN03128  794 QSIEPEWYCPIIPMVLVNGSEGIGTGWSTFIPNYNPRDIIANIRRLLRGEE---LEPMH-------PWYRGFKGT--ITE 861

                         170       180       190
                  ....*....|....*....|....*....|...
gi 507658591  181 AYESGRGSITIRAKAEIEQTSSgkerIIVTELP 213
Cdd:PLN03128  862 VSTSRSGSYTVTGIIEQIGDTT----IRITELP 890
PLN03237 PLN03237
DNA topoisomerase 2; Provisional
 14-143 1.93e-10

DNA topoisomerase 2; Provisional


Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 59.88  E-value: 1.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507658591   14 KSARIVGEV--IGKYHpHGDSAVYESMVRMAQDF---NYRYMLVDGhGNFG--SVDGDSAAAMRYTEARMSKISMEILRD 86
Cdd:PLN03237  728 KVAQLSGYVseHSAYH-HGEQSLASTIIGMAQDFvgsNNINLLLPN-GQFGtrLQGGKDHASARYIFTRLSPITRFLFPK 805

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 507658591   87 ITKDTIDYQDNyDGSEREPV-VMPSrFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGV 143
Cdd:PLN03237  806 DDDILLDYLNE-DGQSIEPTwYMPI-IPTVLVNGAEGIGTGWSTFIPNYNPRDIVANI 861
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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