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Conserved domains on  [gi|585286548|gb|AHJ39442|]
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E1, partial [Hepacivirus hominis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HCV_env super family cl03255
Hepatitis C virus envelope glycoprotein E1;
60-190 4.08e-70

Hepatitis C virus envelope glycoprotein E1;


The actual alignment was detected with superfamily member pfam01539:

Pssm-ID: 110536  Cd Length: 190  Bit Score: 211.28  E-value: 4.08e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585286548   60 EWRNTSGLYVLTNDCSNSSIVYEADDVILHTPGCIPCVQDGNTSTCWTPVTPTVAVRYVGATTASIRSHVDLLVGAATMC 139
Cdd:pfam01539   1 EVRNISGSYHVTNDCSNSSITWQLADAVLHTPGCVPCEREGNTSRCWIAVTPNVAVRHRGALTTSLRTHVDMLVMAATLC 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 585286548  140 SALYVGDMCGAVFLVGQAFTFRPRRHQTVQTCNCSLYPGHLSGHRMAWDMM 190
Cdd:pfam01539  81 SALYVGDLCGSVMLVSQLFTVSPQRHWFTQDCNCSIYPGHITGHRMAWDMM 131
HCV_core super family cl46603
Hepatitis C virus core protein; The viral core protein forms the internal viral coat that ...
 1-57 2.63e-20

Hepatitis C virus core protein; The viral core protein forms the internal viral coat that encapsidates the genomic RNA and is enveloped in a host cell-derived lipid membrane. The core protein has been shown, by yeast two-hybrid assay to interact with cellular DEAD box helicases. The N terminus of the core protein is involved in transcriptional repression.


The actual alignment was detected with superfamily member pfam01542:

Pssm-ID: 480943  Cd Length: 75  Bit Score: 80.49  E-value: 2.63e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 585286548    1 MGYIPLVGAPVGGVARALAHGVRALEDGINFATGNLPGCSFSIFLLALFSCLIHPAA 57
Cdd:pfam01542  19 MGDIKFPGAGLGGAARALAHGRGPLEDGRATAKGNEPGCPFGIFLLALKACLPEGAS 75
 
Name Accession Description Interval E-value
HCV_env pfam01539
Hepatitis C virus envelope glycoprotein E1;
60-190 4.08e-70

Hepatitis C virus envelope glycoprotein E1;


Pssm-ID: 110536  Cd Length: 190  Bit Score: 211.28  E-value: 4.08e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585286548   60 EWRNTSGLYVLTNDCSNSSIVYEADDVILHTPGCIPCVQDGNTSTCWTPVTPTVAVRYVGATTASIRSHVDLLVGAATMC 139
Cdd:pfam01539   1 EVRNISGSYHVTNDCSNSSITWQLADAVLHTPGCVPCEREGNTSRCWIAVTPNVAVRHRGALTTSLRTHVDMLVMAATLC 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 585286548  140 SALYVGDMCGAVFLVGQAFTFRPRRHQTVQTCNCSLYPGHLSGHRMAWDMM 190
Cdd:pfam01539  81 SALYVGDLCGSVMLVSQLFTVSPQRHWFTQDCNCSIYPGHITGHRMAWDMM 131
HCV_core pfam01542
Hepatitis C virus core protein; The viral core protein forms the internal viral coat that ...
 1-57 2.63e-20

Hepatitis C virus core protein; The viral core protein forms the internal viral coat that encapsidates the genomic RNA and is enveloped in a host cell-derived lipid membrane. The core protein has been shown, by yeast two-hybrid assay to interact with cellular DEAD box helicases. The N terminus of the core protein is involved in transcriptional repression.


Pssm-ID: 460245  Cd Length: 75  Bit Score: 80.49  E-value: 2.63e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 585286548    1 MGYIPLVGAPVGGVARALAHGVRALEDGINFATGNLPGCSFSIFLLALFSCLIHPAA 57
Cdd:pfam01542  19 MGDIKFPGAGLGGAARALAHGRGPLEDGRATAKGNEPGCPFGIFLLALKACLPEGAS 75
 
Name Accession Description Interval E-value
HCV_env pfam01539
Hepatitis C virus envelope glycoprotein E1;
60-190 4.08e-70

Hepatitis C virus envelope glycoprotein E1;


Pssm-ID: 110536  Cd Length: 190  Bit Score: 211.28  E-value: 4.08e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585286548   60 EWRNTSGLYVLTNDCSNSSIVYEADDVILHTPGCIPCVQDGNTSTCWTPVTPTVAVRYVGATTASIRSHVDLLVGAATMC 139
Cdd:pfam01539   1 EVRNISGSYHVTNDCSNSSITWQLADAVLHTPGCVPCEREGNTSRCWIAVTPNVAVRHRGALTTSLRTHVDMLVMAATLC 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 585286548  140 SALYVGDMCGAVFLVGQAFTFRPRRHQTVQTCNCSLYPGHLSGHRMAWDMM 190
Cdd:pfam01539  81 SALYVGDLCGSVMLVSQLFTVSPQRHWFTQDCNCSIYPGHITGHRMAWDMM 131
HCV_core pfam01542
Hepatitis C virus core protein; The viral core protein forms the internal viral coat that ...
 1-57 2.63e-20

Hepatitis C virus core protein; The viral core protein forms the internal viral coat that encapsidates the genomic RNA and is enveloped in a host cell-derived lipid membrane. The core protein has been shown, by yeast two-hybrid assay to interact with cellular DEAD box helicases. The N terminus of the core protein is involved in transcriptional repression.


Pssm-ID: 460245  Cd Length: 75  Bit Score: 80.49  E-value: 2.63e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 585286548    1 MGYIPLVGAPVGGVARALAHGVRALEDGINFATGNLPGCSFSIFLLALFSCLIHPAA 57
Cdd:pfam01542  19 MGDIKFPGAGLGGAARALAHGRGPLEDGRATAKGNEPGCPFGIFLLALKACLPEGAS 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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