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Conserved domains on  [gi|599412867|gb|AHN62589|]
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olfactory receptor family 51, partial [Vampyrum spectrum]

Protein Classification

olfactory receptor family 51 protein( domain architecture ID 11607012)

olfactory receptor family 51 protein is an odorant receptor belonging to the G-protein coupled receptor 1 family

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
 1-238 7.90e-136

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320350  Cd Length: 275  Bit Score: 382.62  E-value: 7.90e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILLS---LNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15222   32 HEPMYYFLSmlaVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFMESSVLLAMAFDRFVAICNPLRYASI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15222  112 LTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKLACSDTRVNSIYGLFVVLSTMGLDSLLIL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQYVHTLMSLIYLFVPPMLNPIIYRIK 237
Cdd:cd15222  192 LSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRFGKHASPLVHVLMANVYLLVPPVLNPIIYSVK 271


                 .
gi 599412867 238 T 238
Cdd:cd15222  272 T 272
 
Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
 1-238 7.90e-136

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 382.62  E-value: 7.90e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILLS---LNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15222   32 HEPMYYFLSmlaVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFMESSVLLAMAFDRFVAICNPLRYASI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15222  112 LTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKLACSDTRVNSIYGLFVVLSTMGLDSLLIL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQYVHTLMSLIYLFVPPMLNPIIYRIK 237
Cdd:cd15222  192 LSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRFGKHASPLVHVLMANVYLLVPPVLNPIIYSVK 271


                 .
gi 599412867 238 T 238
Cdd:cd15222  272 T 272
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 1-238 8.92e-93

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 273.61  E-value: 8.92e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867    1 HQPMYILLS---LNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:pfam13853  26 HQPMYLFLAmlaLIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAVLLAMAVDRFVAICSPLRYTTI 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:pfam13853 106 LTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKVNNIYGLFVVTSTFGIDSLLIV 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQYVHTLMSLIYLFVPPMLNPIIYRIK 237
Cdd:pfam13853 186 LSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPPLLQIMMANAYLFFPPVLNPIVYSVK 265


                  .
gi 599412867  238 T 238
Cdd:pfam13853 266 T 266
 
Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
 1-238 7.90e-136

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 382.62  E-value: 7.90e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILLS---LNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15222   32 HEPMYYFLSmlaVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFMESSVLLAMAFDRFVAICNPLRYASI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15222  112 LTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKLACSDTRVNSIYGLFVVLSTMGLDSLLIL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQYVHTLMSLIYLFVPPMLNPIIYRIK 237
Cdd:cd15222  192 LSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRFGKHASPLVHVLMANVYLLVPPVLNPIIYSVK 271


                 .
gi 599412867 238 T 238
Cdd:cd15222  272 T 272
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
 1-238 2.08e-98

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 288.03  E-value: 2.08e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYI---LLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15917   32 HEPMYLflaMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAMESGVLLAMAFDRYVAICYPLRYTTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15917  112 LTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACGDTRVNSIYGLFVALLIVGFDLLFIA 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQYVHTLMSLIYLFVPPMLNPIIYRIK 237
Cdd:cd15917  192 LSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFGHHVPPHVHILLANLYLLLPPMLNPIVYGVR 271


                 .
gi 599412867 238 T 238
Cdd:cd15917  272 T 272
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
 1-238 3.04e-93

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 274.94  E-value: 3.04e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILLSL---NDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15221   32 HEPMYLFLSMlavTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVTESAILLAMAFDRYVAICYPLRYTTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15221  112 LTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACADITVNIWYGLTVALLTVGLDVVLIA 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQYVHTLMSLIYLFVPPMLNPIIYRIK 237
Cdd:cd15221  192 VSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRFGRHIPRHVHILLANLYVLVPPMLNPIVYGVK 271


                 .
gi 599412867 238 T 238
Cdd:cd15221  272 T 272
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 1-238 8.92e-93

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 273.61  E-value: 8.92e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867    1 HQPMYILLS---LNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:pfam13853  26 HQPMYLFLAmlaLIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAVLLAMAVDRFVAICSPLRYTTI 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:pfam13853 106 LTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKVNNIYGLFVVTSTFGIDSLLIV 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQYVHTLMSLIYLFVPPMLNPIIYRIK 237
Cdd:pfam13853 186 LSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPPLLQIMMANAYLFFPPVLNPIVYSVK 265


                  .
gi 599412867  238 T 238
Cdd:pfam13853 266 T 266
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
 1-238 7.19e-91

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 268.75  E-value: 7.19e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILLS---LNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15953   32 HKPMYLLLCmlaLTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIMESAVLVAMAFDRYVAICNPLRYATI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15953  112 LTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACGDTTINRIYGLVVALLVVGLDLLLIA 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQYVHTLMSLIYLFVPPMLNPIIYRIK 237
Cdd:cd15953  192 LSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLTHRFGQGIAPHIHIILANLYLLVPPMLNPIIYGVK 271


                 .
gi 599412867 238 T 238
Cdd:cd15953  272 T 272
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
 1-238 3.15e-88

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 261.93  E-value: 3.15e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYIL---LSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15952   32 HQPMFYFlamLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGMESAVLVAMAFDRYVAICNPLRYTTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLsIVISTFGVDSALIL 157
Cdd:cd15952  112 LTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACASIRINIIYGL-FAISVLVLDVILIA 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQYVHTLMSLIYLFVPPMLNPIIYRIK 237
Cdd:cd15952  191 LSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFGHNIPRYIHILLANLYVVLPPMLNPVIYGVR 270


                 .
gi 599412867 238 T 238
Cdd:cd15952  271 T 271
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
 1-238 2.74e-87

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 259.59  E-value: 2.74e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYI---LLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15951   32 HEPMYLflcMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTMESGIFVAMALDRYVAICNPLRHSTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15951  112 LTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACADTRVSRAYGLSVAFLVGGLDVIFIA 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQYVHTLMSLIYLFVPPMLNPIIYRIK 237
Cdd:cd15951  192 VSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRFGHNVPPHVHILIANVYLLVPPMLNPIIYGVR 271


                 .
gi 599412867 238 T 238
Cdd:cd15951  272 T 272
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
 1-238 9.91e-81

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 242.97  E-value: 9.91e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILLSL---NDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15223   32 HQPMYILLGIlaaVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAMESSILLVMALDRYVAICKPLRYPSI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15223  112 ITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSLACGDTTINSIYGLAVAWLIVGSDIILIF 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQYVHTLMSLIYLFVPPMLNPIIYRIK 237
Cdd:cd15223  192 FSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTYRFGKTIPPDVHVLLSVLYILIPPALNPIIYGVR 271


                 .
gi 599412867 238 T 238
Cdd:cd15223  272 T 272
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
 1-238 1.64e-79

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 240.19  E-value: 1.64e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILLSL---NDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15948   33 HEPMFYFLAMlavIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIMESAVLLAMAFDRYVAICNPLRYATI 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15948  113 LTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACGDTRFNNIYGIAVALFIVGLDLMFII 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQYVHTLMSLIYLFVPPMLNPIIYRIK 237
Cdd:cd15948  193 LSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTMHRFARHVAPHVHILLANFYLLFPPMMNPIVYGVK 272


                 .
gi 599412867 238 T 238
Cdd:cd15948  273 T 273
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
 1-238 2.83e-79

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 239.24  E-value: 2.83e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILLSL---NDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15950   32 HEPMYYFLCMlavIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAVESGVLLAMAFDRYVAICHPLRYSAI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15950  112 LTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLACADPRPSSLYSITGSTLVVGTDSAFIA 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQYVHTLMSLIYLFVPPMLNPIIYRIK 237
Cdd:cd15950  192 VSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLSIYTQRFGQGVPPHTQVLLADLYLLVPPMLNPIIYGMR 271


                 .
gi 599412867 238 T 238
Cdd:cd15950  272 T 272
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
 1-238 2.35e-76

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 232.36  E-value: 2.35e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYI---LLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15949   48 HQPMYFflsMLAIIDLVLSTSTMPKLLAIFWFSSNEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTI 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15949  128 LTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWYRTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIV 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQYVHTLMSLIYLFVPPMLNPIIYRIK 237
Cdd:cd15949  208 LSYIMILRVVQRLATSEARLKTFGTCVSHVCAILAFYVPIAVSSLIHRFGQNVPPPTHILLANFYLLIPPMLNPIVYGVR 287


                 .
gi 599412867 238 T 238
Cdd:cd15949  288 T 288
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
 1-238 6.10e-69

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 213.09  E-value: 6.10e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILLSL---NDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15955   32 HQPMYIFLAMlaaTDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAFESGILLAMALDRYVAICHPLRHSSI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLK-RLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALI 156
Cdd:cd15955  112 LTPQVLLGIGVLVVVRAVVLIIPCPLLIKlRLHHFRSTVISHSYCEHMAVVKLAADDVRVNKIYGLFVAFSILGFDIIFI 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 157 LLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQYVHTLMSLIYLFVPPMLNPIIYRI 236
Cdd:cd15955  192 TTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRFGHHVAPYVHILLSNLYLLVPPVLNPIVYGV 271


                 ..
gi 599412867 237 KT 238
Cdd:cd15955  272 KT 273
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
 1-238 7.43e-68

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 210.11  E-value: 7.43e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILLSL---NDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15956   32 HQPMFLFLAMlaaTDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAMESGVLVAMALDRFVAICNPLHYATI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15956  112 LTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLACGATTVDSLYGLALALFIGGGDVLFIA 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQYVHTLMSLIYLFVPPMLNPIIYRIK 237
Cdd:cd15956  192 YSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFGHSVPSAAHVLLSNLYLLLPPALNPIVYGIR 271


                 .
gi 599412867 238 T 238
Cdd:cd15956  272 T 272
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 1-234 5.65e-62

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 195.01  E-value: 5.65e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd13954   32 HTPMYFFLsnlSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSLGGTECFLLAVMAYDRYVAICHPLHYPTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd13954  112 MNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLKLSCSDTSLNELVIFILAGFVGLGSFLLTL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMaaRYRRYVPQYVHTLMSLIYLFVPPMLNPIIY 234
Cdd:cd13954  192 VSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYV--RPSSSYSSDLDKVVSVFYTVVTPMLNPIIY 266
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
 1-238 5.88e-62

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 195.04  E-value: 5.88e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYI---LLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15954   32 HRPMYYflsMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGMESGVLMLMALDRYVAICYPLRYATI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15954  112 LTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACANIRVDAIYGLMVALLIGGFDILCIS 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARY-RRYVPQYVHTLMSLIYLFVPPMLNPIIYRI 236
Cdd:cd15954  192 VSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRFgGHHITPHIHIIMANLYLLLPPMMNPIVYGV 271


                 ..
gi 599412867 237 KT 238
Cdd:cd15954  272 KT 273
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
 1-234 8.56e-49

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 161.62  E-value: 8.56e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15235   33 HTPMYFFLshlSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDSFLLAVMAYDRYVAICHPLHYATV 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIF----GLSIVISTFgvds 153
Cdd:cd15235  113 MSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLLKLSCSDTSLNELLifteGAVVVLGPF---- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 154 ALILLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQyvHTLMSLIYLFVPPMLNPII 233
Cdd:cd15235  189 LLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSSYSADK--DRVATVMYTVVTPMLNPFI 266


                 .
gi 599412867 234 Y 234
Cdd:cd15235  267 Y 267
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
 1-234 1.15e-46

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 156.08  E-value: 1.15e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15225   32 HTPMYFFLrnlSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGTECFLLAAMAYDRYVAICNPLRYTLI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTdarvARMGMSVIIRSFCTVFPMP----VLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDS 153
Cdd:cd15225  112 MN----RRVCLQLVAGSWLSGILVSlgqtTLIFSLPFCGSNEINHFFCDIPPVLKLACADTSLNEIAIFVASVLVILVPF 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 154 ALILLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYvpmvgVSMAARYRRyvPQYVHT-----LMSLIYLFVPPM 228
Cdd:cd15225  188 LLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFY-----GCASFTYLR--PKSSYSpetdkLLSLFYTVVTPM 260


                 ....*.
gi 599412867 229 LNPIIY 234
Cdd:cd15225  261 LNPIIY 266
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
 1-234 1.66e-46

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 155.51  E-value: 1.66e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYIL---LSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15237   32 HTPMYFFlsnLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALGVTECVLLAVMAYDRYVAICNPLRYSVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINN--IFGLSIVIstFGVDSAL 155
Cdd:cd15237  112 MSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLKLACADTSLNEavIFVTSVLV--LLIPFSL 189

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 599412867 156 ILLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQyvHTLMSLIYLFVPPMLNPIIY 234
Cdd:cd15237  190 ILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHSTHSPDQ--DKMISVFYTIVTPMLNPLIY 266
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
 1-234 2.18e-46

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 154.97  E-value: 2.18e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15230   32 HTPMYFFLsnlSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTECFLLAAMAYDRYVAICNPLLYTVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINN----IFGLSIVISTFGVds 153
Cdd:cd15230  112 MSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKLSCSDTHINElvlfAFSGFIGLSTLLI-- 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 154 alILLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMvgVSMAARYRRYVPQYVHTLMSLIYLFVPPMLNPII 233
Cdd:cd15230  190 --ILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTL--IFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLI 265


                 .
gi 599412867 234 Y 234
Cdd:cd15230  266 Y 266
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
 1-234 1.17e-45

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 153.15  E-value: 1.17e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYIL---LSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15918   32 HTPMYFFlanLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDLDNFLLAVMAYDRYVAICHPLHYTTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYC-LHPdLIRLPCGDITINNIFGLSIVISTFGVDSALI 156
Cdd:cd15918  112 MSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCdLNP-LLKLSCSDTHLNELVILVLGGLVGLVPFLCI 190

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412867 157 LLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQyvHTLMSLIYLFVPPMLNPIIY 234
Cdd:cd15918  191 LVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSHSASK--DSVAAVMYTVVTPMLNPFIY 266
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
 1-234 1.86e-45

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 152.85  E-value: 1.86e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15915   32 HSPMYFFLgnlSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSEAMLLAVMAYDRYVAICNPLRYTVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITIN----NIFGLSIVISTFgvds 153
Cdd:cd15915  112 MNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKLACGDTSLNlwllNIVTGSIALGTF---- 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 154 ALILLSYVLILRSVLAIA-SWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQyvHTLMSLIYLFVPPMLNPI 232
Cdd:cd15915  188 ILTLLSYIYIISFLLLKVrSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSGDSLEQ--DRIVALLYTVVTPVLNPL 265


                 ..
gi 599412867 233 IY 234
Cdd:cd15915  266 IY 267
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
 1-237 3.07e-45

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 152.48  E-value: 3.07e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILLS---LNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYaTV 77
Cdd:cd15420   32 HTPMYFFLShlaVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHTECVLLAVMSYDRYVAICHPLRY-TV 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVaRMGMSVIIRSFCTVFPMP--VLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSAL 155
Cdd:cd15420  111 IMNWRV-CTTLAATSWACGFLLALVhvVLLLRLPFCGPNEVNHFFCEILAVLKLACADTWINEILIFAGCVFILLGPFSL 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 156 ILLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRyvPQYVHTLMSLIYLFVPPMLNPIIYR 235
Cdd:cd15420  190 ILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSN--SAEQEKILSLFYSLFNPMLNPLIYS 267


                 ..
gi 599412867 236 IK 237
Cdd:cd15420  268 LR 269
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
 1-237 1.15e-44

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 150.82  E-value: 1.15e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15229   32 HTPMYFFLshlSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEAFLLSAMAYDRYAAICHPLHYVQI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15229  112 MSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPLSCSDTFANKMVLLTSSVIFGLGSFLLTL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYvpmvgVSMAARYRRYVPQYVHTL---MSLIYLFVPPMLNPIIY 234
Cdd:cd15229  192 VSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFY-----GTGFFRYLRPNSASSSVLdrvFSIQYSILTPMLNPIIY 266


                 ...
gi 599412867 235 RIK 237
Cdd:cd15229  267 SLK 269
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
 1-237 2.33e-43

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 147.37  E-value: 2.33e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYIL---LSLNDLGVSFSTLPTVLATfCFHLRK-ISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYAT 76
Cdd:cd15431   32 HTPMYFFlsnLSFLDICYTTSSVPQMLVN-CLSDRPtISYSRCLAQMYISLFLGITECLLLAVMAYDRFVAICNPLRYTL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  77 VLTDARVARMGMSVIIRSFCTVFpMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALI 156
Cdd:cd15431  111 IMSWRVCIQLAAGSWVSAFLLTV-IPVLTMPLHFCGPNVINHFFCEVQALLKLACSDTSLNEILMFATSIFTLLLPFSFI 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 157 LLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYvpmvGVSMaARYRRyvPQYVHT-----LMSLIYLFVPPMLNP 231
Cdd:cd15431  190 LVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFY----GTAI-FMYLR--PQSKSSsdqdkIISVFYGVVTPMLNP 262


                 ....*.
gi 599412867 232 IIYRIK 237
Cdd:cd15431  263 LIYSLR 268
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
 1-234 7.38e-43

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 145.70  E-value: 7.38e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15912   32 HTPMYFFLrnfSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFLGTTEFFLLAVMSFDRYVAICNPLHYPTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDIT----INNIFGLSIVISTFgvds 153
Cdd:cd15912  112 MNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLKLSCSDTRlielLDFILASVVLLGSL---- 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 154 ALILLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYvpmvGVS--MAARYRRYVPQYVHTLMSLIYLFVPPMLNP 231
Cdd:cd15912  188 LLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFY----GSCifMYVRPSQSSSLDLNKVVALLNTVVTPLLNP 263


                 ...
gi 599412867 232 IIY 234
Cdd:cd15912  264 FIY 266
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
 1-234 1.94e-42

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 145.10  E-value: 1.94e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYIL---LSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15231   32 HTPMYFFlsnLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVGTECLLLAVMAYDRYVAICNPLHYAVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15231  112 MSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLKLSCSDTSLNEVLLLVASVFIGLTPFLFIV 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYvpmvgVSMAARYRRYVPQY---VHTLMSLIYLFVPPMLNPIIY 234
Cdd:cd15231  192 ISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFY-----GTAIFNYNRPSSGYsldKDTLISVLYSIVTPMLNPIIY 266
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
 1-237 2.23e-42

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 144.85  E-value: 2.23e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILLS---LNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15412   32 HTPMYFFLShlsFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVITEYYMLAVMAYDRYMAICNPLLYSVK 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIfgLSIVISTFGVDSAL-- 155
Cdd:cd15412  112 MSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIKLSCSDTYVKET--AMFIVAGFNLSSSLli 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 156 ILLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQyvHTLMSLIYLFVPPMLNPIIYR 235
Cdd:cd15412  190 ILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSEESVEQ--SKIVAVFYTFVSPMLNPLIYS 267


                 ..
gi 599412867 236 IK 237
Cdd:cd15412  268 LR 269
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
 1-237 2.25e-42

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 145.16  E-value: 2.25e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYIL---LSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15408   45 HTPMYFFlshLSFLDICYSSTITPKTLLNLLAERKVISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVI 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15408  125 MSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGSNVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVIL 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYvpmvgVSMAARYRRYVPQYVHTLM---SLIYLFVPPMLNPIIY 234
Cdd:cd15408  205 ISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLFY-----GSLAFMYLRPSSRYSLDLDkvaSVFYTVVIPMLNPLIY 279


                 ...
gi 599412867 235 RIK 237
Cdd:cd15408  280 SLR 282
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
 1-234 3.85e-42

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 144.13  E-value: 3.85e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYIL---LSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15227   32 HTPMYFFlknLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFFAASELALLTVMAYDRYVAICHPLHYEVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSF-------CTVFpmpvllkRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNI----FGLSIVI 146
Cdd:cd15227  112 MNRGACVQMAAASWLSGLlygalhtANTF-------SLPFCGSNVIHQFFCDIPQLLKLSCSDTYLNEIgvlvLSVCLGL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 147 STFgvdsALILLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPmvGVSMAARYRRYVPQYVHTLMSLIYLFVP 226
Cdd:cd15227  185 GCF----VFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLST--GSFAYLKPPSDSPSLLDLLLSVFYSVVP 258


                 ....*...
gi 599412867 227 PMLNPIIY 234
Cdd:cd15227  259 PTLNPIIY 266
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
 1-234 1.73e-41

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 142.78  E-value: 1.73e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILLS---LNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15417   32 HTPMYFFLSnlsFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLTECFLLAAMAYDRYVAICNPLLYSVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFgLSIVISTFGVDSAL-I 156
Cdd:cd15417  112 MSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSLSCSDTFISQVV-LFLVAVLFGVFSVLvV 190

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412867 157 LLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPmvGVSMAARYRRYVPQYVHTLMSLIYLFVPPMLNPIIY 234
Cdd:cd15417  191 LISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGT--GLFVYLRPSSSHSQDQDKVASVFYTVVIPMLNPLIY 266
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
 1-234 2.72e-41

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 141.95  E-value: 2.72e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15234   32 HTPMYFFLsnlSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGGLDNFLLAVMAYDRYVAICHPLHYTVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15234  112 MNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKLACSDTLINNILIYLATVIFGGIPLSGII 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARyrryVPQYVHTLM--SLIYLFVPPMLNPIIY 234
Cdd:cd15234  192 FSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSA----VTHSSRKTAvaSVMYTVVTPMLNPFIY 266
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
 1-237 4.42e-41

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 142.12  E-value: 4.42e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYIL---LSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15943   46 HTPMYFFlshLSFLDLCYSSAITPKMLVNFLAENKTISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVI 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNI--FGLSIVISTFgvDSAL 155
Cdd:cd15943  126 MSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGSNVINHFFCDVPPLLKLSCSDTHVNEIvlFAFAIFLGIF--TSLE 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 156 ILLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVsmaarYRRYVPQYV---HTLMSLIYLFVPPMLNPI 232
Cdd:cd15943  204 ILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTIFYGTTLFM-----YLRPSSSYSldqDKVVSVFYTVVIPMLNPL 278


                 ....*
gi 599412867 233 IYRIK 237
Cdd:cd15943  279 IYSLR 283
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
 1-234 5.79e-41

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 141.30  E-value: 5.79e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15411   32 HTPMYFFLsnlSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTECFLLGLMAYDRYVAICNPLLYTVV 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15411  112 MSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKLSCSDTHVNEMLIFILAGLTLVGSLLIIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMaaRYRRYVPQYVHTLMSLIYLFVPPMLNPIIY 234
Cdd:cd15411  192 VSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYL--RPSSSYSLGQDKVASVFYTVVIPMLNPLIY 266
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
 1-234 9.83e-41

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 140.58  E-value: 9.83e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYIL---LSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15430   32 HTPMYFFlgnLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTECVLLAVMAYDRYVAICNPLRYPII 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15430  112 MNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLKLACVDISLNEIIMLVGNIIFLVIPLLLIC 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMvgVSMAARYRRYVPQYVHTLMSLIYLFVPPMLNPIIY 234
Cdd:cd15430  192 ISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTI--LFMYMKPKSKNAQISDKLITLFYGVVTPMLNPIIY 266
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
 1-234 1.53e-40

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 140.07  E-value: 1.53e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15947   32 HTPMYFFLsnlSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWLGSTECVLLAVMAFDRYVAVCRPLHYTVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINN--IFGLSIVIStfGVDSAL 155
Cdd:cd15947  112 MHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIKLACVDTTFNEleLFVASVFFL--LVPLSL 189

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 599412867 156 ILLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRyvPQYVHTLMSLIYLFVPPMLNPIIY 234
Cdd:cd15947  190 ILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSY--SQDQGKFISLFYTVVTPTLNPLIY 266
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
 1-237 3.40e-40

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 139.04  E-value: 3.40e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYI---LLSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15914   32 HTPMYFfisILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHSLGITECYLLTAMAYDRYLAICNPLHYPSI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGD----ITINNIFGLSIVISTFgvds 153
Cdd:cd15914  112 MTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLSLACTDtslnVLVDFVIHAVIILLTF---- 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 154 ALILLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMvgVSMAARYRRYVPQYVHTLMSLIYLFVPPMLNPII 233
Cdd:cd15914  188 LLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSV--SFMYLRLSKSYSLDYDRAIAVVYAVLTPFFNPII 265


                 ....
gi 599412867 234 YRIK 237
Cdd:cd15914  266 YSLR 269
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
 1-237 4.24e-40

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 139.08  E-value: 4.24e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15409   32 HTPMYFFLgnlAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTECFLLAAMAYDRYVAICNPLLYPVV 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDarvaRMGMSVIIRSFCTVFPMP----VLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINN----IFGLSIVISTF 149
Cdd:cd15409  112 MSN----RLCVQLITASYIGGFLHSmihvGLTFRLSFCGSNEINHFFCDIPPLLKISCTDPSINElvlfIFSGSIQVFTI 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 150 GVdsalILLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMvgVSMAARYRRYVPQYVHTLMSLIYLFVPPML 229
Cdd:cd15409  188 LT----VLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSL--FFMYVRPSSLYALDQDMMDSLFYTIVIPLL 261


                 ....*...
gi 599412867 230 NPIIYRIK 237
Cdd:cd15409  262 NPFIYSLR 269
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
 1-234 5.85e-40

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 138.39  E-value: 5.85e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15911   32 HTPMYFFLgnlSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLAATECYLLAVMSYDRYLAICKPLHYASL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15911  112 MNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLSCSDTSLVELVTFILSSIVTLPPFLLTL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAAryRRYVPQYVHTLMSLIYLFVPPMLNPIIY 234
Cdd:cd15911  192 TSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVP--STNTSRDLNKVFSLFYTVLTPLVNPLIY 266
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
 1-234 6.67e-40

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 138.60  E-value: 6.67e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15419   32 HTPMYFFLmnlSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTTEGFLLAAMAYDRFIAICNPLLYPVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNI--FGLS--IVISTFGVds 153
Cdd:cd15419  112 MSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLLKLSCSDTFINELvmFVLCglIIVSTILV-- 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 154 alILLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYvpmvgvsMAARYRRYVPQYVHT-----LMSLIYLFVPPM 228
Cdd:cd15419  190 --ILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFY-------GTVFFMYAQPGAVSSpeqskVVSVFYTLVIPM 260


                 ....*.
gi 599412867 229 LNPIIY 234
Cdd:cd15419  261 LNPLIY 266
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
 1-234 1.76e-39

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 137.79  E-value: 1.76e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15410   45 HTPMYFFLshlSFVDFCYSSVIAPKMLVNFLAEDKAISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVI 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINN----IFGLSIVISTFGVds 153
Cdd:cd15410  125 MSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGSNVINHFFCDLPPLLSLSCSDTYLNElllfIFGSLNEASTLLI-- 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 154 alILLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVgvsmaarYRRYVPQYVHTL-----MSLIYLFVPPM 228
Cdd:cd15410  203 --ILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIFHGTIL-------FMYCRPSSSYSLdtdkvASVFYTVVIPM 273


                 ....*.
gi 599412867 229 LNPIIY 234
Cdd:cd15410  274 LNPLIY 279
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
 1-234 1.00e-38

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 135.63  E-value: 1.00e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILLS---LNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15407   32 HTPMYFFLSnlsLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFATVENFLLASMAYDRHAAVCKPLHYTTT 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIfgLSIVISTFGVDSAL-- 155
Cdd:cd15407  112 MTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLALSCSDIHISEI--VLFFLASFNVFFALlv 189

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 599412867 156 ILLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPqyVHTLMSLIYLFVPPMLNPIIY 234
Cdd:cd15407  190 ILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHSMD--TDKMASVFYTMVIPMLNPLVY 266
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
 1-234 1.31e-38

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 135.10  E-value: 1.31e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILLS----LNDLGVSFsTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYAT 76
Cdd:cd15224   32 HKPMYFFLSnlsfLEIWYISV-TVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACTECVLLAVMAYDRYVAICHPLRYPV 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  77 VLTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALI 156
Cdd:cd15224  111 IMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNLSCTDMSLAELVDFILALIILLVPLLVT 190

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412867 157 LLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMvgVSMAARYRRYVPQYVHTLMSLIYLFVPPMLNPIIY 234
Cdd:cd15224  191 VASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSAT--LFMYARPKAISSFDSNKLVSVLYTVVTPLLNPIIY 266
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
 1-234 2.49e-38

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 134.42  E-value: 2.49e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILLS---LNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15416   32 HTPMYFFLShlaFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFGTVECFLLAAMAYDRYVAICNPLLYSTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15416  112 MSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKLSCSDIRLAKILPSISSGIIILVTVLTII 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQyvHTLMSLIYLFVPPMLNPIIY 234
Cdd:cd15416  192 ISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSYSMDQ--NKVVSVFYMVVIPMLNPLIY 266
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
 1-237 2.69e-38

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 134.53  E-value: 2.69e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYIL---LSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15432   32 HTPMYFFlsnLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLGSTECVLLAVMAFDRFAAICQPLHYSVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15432  112 MHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLKLSCVDTTANEAELFVISVLLLLIPLGLIL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYvpMVGVSMAARYRRYVPQYVHTLMSLIYLFVPPMLNPIIYRIK 237
Cdd:cd15432  192 ISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFY--GTAISMYLQPPSNSSHDRGKMVALFYGIITPMLNPLIYTLR 269
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
 1-234 3.97e-38

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 133.54  E-value: 3.97e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYIL---LSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15232   32 HTPMYFFlvnLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGSELLLLTAMAYDRYVAICHPLHYSTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15232  112 MRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLSCSDTSLNEIMAFVADVFFGVGNFLLTL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVgvsmaarYRRYVPQYVHTL-----MSLIYLFVPPMLNPI 232
Cdd:cd15232  192 TSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVI-------YTYIRPSSSYSPekdkvVAVLYSVVTPTLNPL 264


                 ..
gi 599412867 233 IY 234
Cdd:cd15232  265 IY 266
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
 1-234 8.96e-38

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 132.83  E-value: 8.96e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILLS---LNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15413   32 QTPMYFFLRhlaFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIISELFLLSAMAYDRYVAICNPLLYTVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIfgLSIVISTFGVDSAL-- 155
Cdd:cd15413  112 MSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLALSCSDTHEKEL--IILIFAGFNLISSLli 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 156 ILLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAaryrryvPQYVHTL-----MSLIYLFVPPMLN 230
Cdd:cd15413  190 VLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQ-------PKSSHSLdtdkmASVFYTLVIPMLN 262


                 ....
gi 599412867 231 PIIY 234
Cdd:cd15413  263 PLIY 266
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
 1-234 9.97e-38

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 132.96  E-value: 9.97e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFC-FHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYAT 76
Cdd:cd15916   32 HRPMYIFLghlSFLDMWLSTVTVPKMLAGFLePGGKVISFGGCVAQLYFFHFLGSTECFLYTLMAYDRYLAICHPLHYPT 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  77 VLTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIfglsIVISTFGVDSA-- 154
Cdd:cd15916  112 IMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLKLACADTTINEL----VIFASIGVVALgc 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 155 --LILLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRryvpQYVHTLMSLIYLFVPPMLNPI 232
Cdd:cd15916  188 fiLILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSK----EALDGVIAVFYTVVTPLLNPL 263


                 ..
gi 599412867 233 IY 234
Cdd:cd15916  264 IY 265
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
 1-234 2.87e-37

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 132.11  E-value: 2.87e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15406   41 HTPMYYFLsnlSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVT 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15406  121 MSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAIL 200

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQyvHTLMSLIYLFVPPMLNPIIY 234
Cdd:cd15406  201 ISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFMYLKPSSSSSMTQ--EKVSSVFYTTVIPMLNPLIY 275
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
 1-237 5.22e-37

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 130.98  E-value: 5.22e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15429   32 HTPMYFFLshlSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALGGTEFILLAVMAYDRYVAVCHPLRYTVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15429  112 MSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRLACVDTSLNEVAILVSSVVVLLTPCFLVL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMaaRYRRYVPQYVHTLMSLIYLFVPPMLNPIIYRIK 237
Cdd:cd15429  192 LSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYM--RPRSGSSALQEKMISLFYAVVTPMLNPLIYSLR 269
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
 1-237 8.34e-37

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 130.61  E-value: 8.34e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYIL---LSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15405   32 HTPMYFFlfnLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVISECYVLTAMAYDRYVAICNPLLYTVT 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15405  112 MSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQLSCTSTYVNELVVFVVVGINIIVPSVTIF 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYvpMVGVSMAARYRRYVPQYVHTLMSLIYLFVPPMLNPIIYRIK 237
Cdd:cd15405  192 ISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFF--GSGAFMYLKPSSVGSVNQGKVSSVFYTNVVPMLNPLIYSLR 269
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
 1-237 2.16e-36

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 129.46  E-value: 2.16e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15415   32 HTPMYFFLsnlSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTTEGFLLAVMAYDRYVAICNPLLYTVA 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNI----FGLSIVISTFGVds 153
Cdd:cd15415  112 MTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLSCSDTHINELllltFSGVIAMSTLLT-- 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 154 alILLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQyvHTLMSLIYLFVPPMLNPII 233
Cdd:cd15415  190 --IIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQYSLEQ--EKVSAVFYTLVIPMLNPLI 265


                 ....
gi 599412867 234 YRIK 237
Cdd:cd15415  266 YSLR 269
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
 1-234 2.51e-36

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 129.21  E-value: 2.51e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYIL---LSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYaTV 77
Cdd:cd15421   32 HTPMYFLlsqLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLGGAECLLLALMAYDRYVAICHPLRY-PV 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARV-ARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITinnIFGLSIVISTFG---VDS 153
Cdd:cd15421  111 LMSPRVcLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLKLSCADTS---AYETVVYVSGVLfllIPF 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 154 ALILLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMaaryrryVPQYVHT-----LMSLIYLFVPPM 228
Cdd:cd15421  188 SLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYM-------RPGSYHSpeqdkVVSVFYTILTPM 260


                 ....*.
gi 599412867 229 LNPIIY 234
Cdd:cd15421  261 LNPLIY 266
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
 1-234 2.81e-36

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 128.87  E-value: 2.81e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYIL---LSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15939   32 GSPMYFFlsyLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEIFLLTVMAYDRYVAICKPLHYTTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYC-LHPdLIRLPCGDITINNIF----GLSIVISTFgvd 152
Cdd:cd15939  112 MNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCdLFP-LLKLACTDTYVIGLLvvanSGLICLLSF--- 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 153 sALILLSYVLILRSvLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMaaryRRYVPQYVHTLMSLIYLFVPPMLNPI 232
Cdd:cd15939  188 -LILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYM----RPVTTFPIDKVVAVFYTIITPMLNPL 261


                 ..
gi 599412867 233 IY 234
Cdd:cd15939  262 IY 263
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
 1-234 8.70e-35

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 125.01  E-value: 8.70e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15226   32 HSPMYFLLanlSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGSEMVLLIAMAFDRYVAICKPLHYLTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFglsiVISTFGVDS---- 153
Cdd:cd15226  112 MSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIKLACTDTYVLELM----VVANSGLISlvcf 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 154 ALILLSYVLILRSVLAIASwEERLKTLNTCVSHMCAVLIFYVPMVGVsmaarYRRYVPQY-VHTLMSLIYLFVPPMLNPI 232
Cdd:cd15226  188 LLLLISYIVILVTVRKHSS-GGSSKALSTCSAHITVVVLFFGPCIFI-----YVWPFSTFpVDKFLAVFYTVITPLLNPI 261


                 ..
gi 599412867 233 IY 234
Cdd:cd15226  262 IY 263
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
 1-234 3.32e-34

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 123.69  E-value: 3.32e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILLS-LNDLGVSF--STLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15424   32 HTPMYFFLShLAGLEICYvtSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGSTECLLLGAMAYDRYLAICHPLLYAAA 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINN--IFGLSIVISTFGVdsAL 155
Cdd:cd15424  112 MGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKLACADTHITEaiVFGAGVLILLVPL--SV 189

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 599412867 156 ILLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMvgVSMAARYRRYVPQYVHTLMSLIYLFVPPMLNPIIY 234
Cdd:cd15424  190 ILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTV--ISMYMRPRSGSTPDRDKQIAVFYIVITPLLNPIIY 266
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
 1-237 2.09e-33

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 122.16  E-value: 2.09e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15945   45 HTPMYYFLsnlSFLDLCYSTAIGPKMLVDLLAKRKSIPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTA 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIfgLSIVISTFGVDSAL-- 155
Cdd:cd15945  125 MSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGSNTINHFFCDIPPLLALSCSDTQINEL--LLFALCGFIQTSTFla 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 156 ILLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARyRRYVPQyVHTLMSLIYLFVPPMLNPIIYR 235
Cdd:cd15945  203 IIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLFYGTLLFMYLRPS-SSYSLD-TDKMTSVFYTLVIPMLNPLIYS 280


                 ..
gi 599412867 236 IK 237
Cdd:cd15945  281 LR 282
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
 1-237 3.44e-33

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 121.00  E-value: 3.44e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15228   32 HTPMYFFLcnlSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLGSTECLLYTVMAYDRYVAICHPLRYLLI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15228  112 MNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLKLACADTSIAETVSFTNVGLVPLTCFLLIL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQYVHTLMSLiylfVPPMLNPIIYRIK 237
Cdd:cd15228  192 ASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPSPVLVTPVQIFNNV----VTPMLNPLIYTLR 267
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
 1-237 4.13e-33

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 120.99  E-value: 4.13e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYIL---LSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15414   32 HTPMYFFlshLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFVAAECFLLASMAYDRYVAICNPLLYTVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFgLSIVISTFGVDSAL-I 156
Cdd:cd15414  112 MSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLSLSCADTQINKWV-LFIMAGALGVLSGLiI 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 157 LLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMaaRYRRYVPQYVHTLMSLIYLFVPPMLNPIIYRI 236
Cdd:cd15414  191 LVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYV--RPSSSSSLDLDKVVSVFYTAVIPMLNPLIYSL 268


                 .
gi 599412867 237 K 237
Cdd:cd15414  269 R 269
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
 1-234 5.81e-33

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 120.13  E-value: 5.81e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15936   32 HTPMYFLLanlAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGAEVFLLSVMAYDRYIAIHKPLHYLTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLS----IVISTFGvds 153
Cdd:cd15936  112 MNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKLACTDTFLLELLMVSnsglVTLLIFF--- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 154 aLILLSYVLILRSvLAIASWEERLKTLNTCVSHMCAVLIFYVPmvGVSMAARYRRYVPqyVHTLMSLIYLFVPPMLNPII 233
Cdd:cd15936  189 -ILLISYTVILVK-IRTHVTEGKRKALSTCASQITVVTLIFVP--CIYIYARPFQTFP--MDKAVSVLYTVITPMLNPMI 262


                 .
gi 599412867 234 Y 234
Cdd:cd15936  263 Y 263
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
 1-234 6.59e-33

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 120.26  E-value: 6.59e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILLS---LNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15236   32 HTPMYFFLShlaFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLDSFLLAVMAYDRYVAICHPLHYTAI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDAR-VARMGMSVIIRSFCTVFpMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALI 156
Cdd:cd15236  112 MRPELcVLLVAGSWVLTCFHALL-HTLLLARLSFCADNVIPHFFCDLVALLKLSCSSTSLNELVIFTEGGLLFVLPLLLI 190

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412867 157 LLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRyvPQYVHTLMSLIYLFVPPMLNPIIY 234
Cdd:cd15236  191 LGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNN--SSDKDIVASVMYTVVTPMLNPFIY 266
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
 1-237 7.49e-33

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 119.85  E-value: 7.49e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15940   32 HTPMYFFLsnlSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTEIFLLTIMAYDRYVAICNPLHYPTV 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFglsiVISTFGVDS---- 153
Cdd:cd15940  112 MNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKLACTDTYLIDIL----IVSNSGLISlvcf 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 154 ALILLSYVLILRSVLAIASwEERLKTLNTCVSHMCAVLIFYVPMVGVSMaaryRRYVPQYVHTLMSLIYLFVPPMLNPII 233
Cdd:cd15940  188 VALLGSYIVILVSLRKRST-EGRRKALSTCASHLTVVTLFFGPCIFIYT----RPSTSFSEDKVVSVFYTVVTPLLNPII 262


                 ....
gi 599412867 234 YRIK 237
Cdd:cd15940  263 YTLR 266
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
 1-237 1.06e-32

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 120.27  E-value: 1.06e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15944   45 HTPMYFFLcnlSFCDLGYSSAIAPRMLADFLTKHKVISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTL 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15944  125 MSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGSNIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIIL 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYvpmvGVSMAARYRryvPQYVHTL-----MSLIYLFVPPMLNPI 232
Cdd:cd15944  205 ISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLFY----GTVIFMYLR---PTSVYSLdqdkwASVFYTVVIPMLNPL 277


                 ....*
gi 599412867 233 IYRIK 237
Cdd:cd15944  278 IYSLR 282
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
 1-237 2.97e-32

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 118.73  E-value: 2.97e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYIL---LSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15418   33 HTPMYFFvgnLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYSECFLLAAMAYDRYVAICNPLLYSSA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15418  113 MSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVKLACDDTRVYELILYFILGFNVIAPTALIL 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYvpmvgVSMAARYRRYVPQYV---HTLMSLIYLFVPPMLNPIIY 234
Cdd:cd15418  193 ASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYY-----GSILFIYSRPSSSHTpdrDKVVALFYTVVNPLLNPLIY 267


                 ...
gi 599412867 235 RIK 237
Cdd:cd15418  268 SLR 270
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
 1-237 5.43e-32

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 117.97  E-value: 5.43e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15233   32 HTPMYFFLgnlSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGADCFLLTAMAYDRYLAICQPLTYSVR 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LT-DARVARMGMSVIIrSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALI 156
Cdd:cd15233  112 MSwRVQTALVGISCAC-AFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQLSCSSTHLNELLLFVFAFFMALAPCVLI 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 157 LLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYvpMVGVSMAARYRRYVPQYVHTLMSLIYLFVPPMLNPIIYRI 236
Cdd:cd15233  191 VVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFY--GTGVFSYMRLGSVYSSDKDKVIGILNTVLSPMLNPLIYSL 268


                 .
gi 599412867 237 K 237
Cdd:cd15233  269 R 269
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
 1-237 5.81e-32

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 117.97  E-value: 5.81e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15428   32 HTPMYFFLsnlSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFGITECALLSVMSYDRYVAICLPLRYSLI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15428  112 MTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLKLASTDTHQAEMAMFIMCVFTLVLPVLLIL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARyRRYVPQYVhTLMSLIYLFVPPMLNPIIYRIK 237
Cdd:cd15428  192 ASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPK-SSTSKEYD-KMISVFYIIVTPMLNPLIYSLR 269
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
 3-237 1.27e-31

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 116.79  E-value: 1.27e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   3 PMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATVLT 79
Cdd:cd15935   35 PMYFFLanlSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMN 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  80 DARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIfglsIVISTFGVDS----AL 155
Cdd:cd15935  115 RQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVIKLACMDTYVVEV----LMVANSGLLSlvcfLV 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 156 ILLSYVLILRSVLAIASwEERLKTLNTCVSHMCAVLIFYVPMVGVSMaaryRRYVPQYVHTLMSLIYLFVPPMLNPIIYR 235
Cdd:cd15935  191 LLVSYGIILTTLRGRFR-EGGGKALSTCSSHLTVVSLIFVPCIFVYL----RPFSSSSVDKVASVFYTLITPALNPLIYT 265


                 ..
gi 599412867 236 IK 237
Cdd:cd15935  266 LR 267
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
 3-237 5.10e-31

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 114.97  E-value: 5.10e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   3 PMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATVLT 79
Cdd:cd15938   34 PMYFLLgnlSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAAEMFLLTVMAYDRYVAICKPLHYTTIMS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  80 DARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALILLS 159
Cdd:cd15938  114 RRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKLACTDTCVTELLMVSNSGLISTVCFVVLVTS 193

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412867 160 YVLILrsvLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMaaryRRYVPQYVHTLMSLIYLFVPPMLNPIIYRIK 237
Cdd:cd15938  194 YTTIL---VTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYA----RPFSTFPVDKHVSVLYNVITPMLNPLIYTLR 264
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
 1-237 7.16e-31

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 114.88  E-value: 7.16e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYIL---LSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15946   32 HTPMYFFlsvLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGITECTLFSVMAYDRYVAICHPLRYKVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15946  112 MSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLKLACADTSLNEMVDFVLGVIVLVVPLSLIL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARyRRYVPQYvHTLMSLIYLFVPPMLNPIIYRIK 237
Cdd:cd15946  192 ASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPG-SNYSPER-DKKISLFYNVFTALLNPVIYSLR 269
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
 1-237 3.08e-30

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 113.30  E-value: 3.08e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15942   32 HKPMYWFLchlSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCAECFLYTVMAYDRFLAICKPLHYSTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALIL 157
Cdd:cd15942  112 MNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLACADTAFNELVTFIDIGLVAMTCFLLIL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 158 LSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMaaryRRYVPQYVHTLMSLIYLFVPPMLNPIIYRIK 237
Cdd:cd15942  192 MSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYL----RPGSQDPLDGVVAVFYTTVTPLLNPVIYTLR 267
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
 1-237 5.58e-30

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 112.47  E-value: 5.58e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15434   32 HTPMYFFLanlSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALGLGGTECVLLAVMAYDRYAAVCQPLHYTVV 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTdarvARMGMSVIIRSFCTVFPMPVLLKRLTF----CKNNVLSHAYCLHPDLIRLPCGDITI--NNIFGLSIVISTFGV 151
Cdd:cd15434  112 MH----PRLCWKLVAMSWLIGFGNSLVLSPLTLslprCGHHRVDHFFCEMPALIKLACVDTTAyeATIFALGVFILLFPL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 152 dsALILLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRryVPQYVHTLMSLIYLFVPPMLNP 231
Cdd:cd15434  188 --SLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNS--VSQDQGKFLTLFYTIVTPSLNP 263


                 ....*.
gi 599412867 232 IIYRIK 237
Cdd:cd15434  264 LIYTLR 269
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
 1-234 3.93e-29

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 110.10  E-value: 3.93e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15913   32 HTPMYILLgnfSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSLGTTECFFLSVMAFDRYLAICRPLHYPTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFcTVFPMPV-LLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLS----IVISTFgvd 152
Cdd:cd15913  112 MTGQLCGKLVAFCWVCGF-LWFLIPVvLISQLPFCGPNIIDHFLCDPGPLLALSCVPAPGTELICYTlsslIIFGTF--- 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 153 sALILLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFY--VPMVGVSMAARYrryvPQYVHTLMSLIYLFVPPMLN 230
Cdd:cd15913  188 -LFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYgsVMVMYVSPGSGN----STGMQKIVTLFYSVVTPLLN 262


                 ....
gi 599412867 231 PIIY 234
Cdd:cd15913  263 PLIY 266
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
 1-237 1.64e-27

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 106.03  E-value: 1.64e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYIL---LSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd15433   32 HTPMYYFlchLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALGSAECVLLAVMAFDRYAAVCRPLHYAAL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDI--TINNIFGLSIVIstFGVDSAL 155
Cdd:cd15433  112 MSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLKLACGDDetTEVQMFVARVVI--LLLPAAL 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 156 ILLSYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYvpmvgVSMAARYRRYVPQYVHT---LMSLIYLFVPPMLNPI 232
Cdd:cd15433  190 ILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFY-----GSAIYTYLQPIHRYSQAhgkFVSLFYTVMTPALNPL 264


                 ....*
gi 599412867 233 IYRIK 237
Cdd:cd15433  265 IYTLR 269
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
 3-237 1.12e-26

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 103.77  E-value: 1.12e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   3 PMYILL---SLNDLGVSFSTLPTVLATF-CFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATVL 78
Cdd:cd15941   35 PMYHFLghlSFLDACLSSVTVPKVLAGLlTLSGRTISFEGCVVQLYAFHFLASTECFLYTVMAYDRYLAICHPLHYPTAM 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  79 TDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFGLSIVISTFGVDSALILL 158
Cdd:cd15941  115 NRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPVLKLACADTTINELVILANIGIVAAGCFLLIVI 194

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 599412867 159 SYVLILRSVLAIASWEERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRryvpQYVHTLMSLIYLFVPPMLNPIIYRIK 237
Cdd:cd15941  195 SYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSSS----QAGAGAPAVFYTIVTPMLNPFIYTLR 269
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
 3-234 2.27e-23

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 94.80  E-value: 2.27e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   3 PMYILL---SLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATVLT 79
Cdd:cd15937   34 PMYFFLanlALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHFLGAAEMFLLVAMAYDRYVAICKPLHYTTVVN 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  80 DARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNI--FGLSIVISTFGVdsALIL 157
Cdd:cd15937  114 RRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIKLACTNTYTVELlmFSNSGLVILLCF--LLLL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 599412867 158 LSYVLILrSVLAIASWEERLKTLNTCVSHMCAVLIFYVPmvGVSMAARYRRYVPqyVHTLMSLIYLFVPPMLNPIIY 234
Cdd:cd15937  192 ISYAFLL-AKLRTHSSKGKSKAASTCITHIIIVFVMFGP--AIYIYARPFRSFP--MDKVVAVFHTVIFPLLNPMIY 263
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
 1-234 2.68e-16

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 75.41  E-value: 2.68e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867    1 HQPMYIL---LSLNDLGVSFSTLPTVLATFCFHLRK-ISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYAT 76
Cdd:pfam00001  16 RTPTNIFllnLAVADLLFSLLTLPFWLVYYLNHGDWpFGSALCKIVGALFVVNGYASILLLTAISIDRYLAIVHPLRYKR 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   77 VLTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLirlpcgdiTINNIFGLSIVISTFGVDSALI 156
Cdd:pfam00001  96 RRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVTVCFIDFPEDL--------SKPVSYTLLISVLGFLLPLLVI 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  157 LLSYVLILRSVLAIAS-------WEERLKTLNTCVSHMCAVLIFYVP--MVGVSMAARYRRYVPQYVHTLMSLIYLF--V 225
Cdd:pfam00001 168 LVCYTLIIRTLRKSASkqksserTQRRRKALKTLAVVVVVFILCWLPyhIVNLLDSLALDCELSRLLDKALSVTLWLayV 247


                  ....*....
gi 599412867  226 PPMLNPIIY 234
Cdd:pfam00001 248 NSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
 8-234 4.79e-10

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 58.07  E-value: 4.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   8 LSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATVLTDARVARMG 87
Cdd:cd00637   40 LAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLI 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  88 MSVIIRSFCTVFPMPVLLKRLTFCknnvlshayclHPDLIRLPCGDITINNIFGLSIVISTFGVDSALILLSYVLILRSV 167
Cdd:cd00637  120 ALIWLLSLLLALPPLLGWGVYDYG-----------GYCCCCLCWPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKL 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867 168 LAIASW--------------EERLKTLNTCVSHMCAVLIFYVPMVGVSMAARYRRYVPQYVHTLMSLIYL--FVPPMLNP 231
Cdd:cd00637  189 RRHRRRirssssnssrrrrrRRERKVTKTLLIVVVVFLLCWLPYFILLLLDVFGPDPSPLPRILYFLALLlaYLNSAINP 268


                 ...
gi 599412867 232 IIY 234
Cdd:cd00637  269 IIY 271
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
 8-165 1.09e-03

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 39.54  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   8 LSLNDLGVSFSTLPTVLA-----TFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATVLTDAR 82
Cdd:cd14978   41 LAVSDILVLLSALPLFLLpyiadYSSSFLSYFYAYFLPYIYPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRR 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  83 VARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDLIRLPCGDITINNIFglSIVISTFGVDSALILLSYVL 162
Cdd:cd14978  121 ARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTLLRQNETYLLKYYFWL--YAIFVVLLPFILLLILNILL 198


                 ...
gi 599412867 163 ILR 165
Cdd:cd14978  199 IRA 201
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
 43-196 1.62e-03

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 38.79  E-value: 1.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  43 MFFIHFFSvteSGILL-VMSFDRYVAICNPLRYATvLTDARVARMgMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYC 121
Cdd:cd14982   79 LFYINMYG---SILFLtCISVDRYLAVVHPLKSRR-LRRKRYAVG-VCAGVWILVLVASVPLLLLRSTIAKENNSTTCFE 153

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 599412867 122 LHPDLIRLPCGDITINNIFGlsivistFGVDSALILLSYVLILRSVLAIA----SWEERLKTLNTCVSHMCAVLIFYVP 196
Cdd:cd14982  154 FLSEWLASAAPIVLIALVVG-------FLIPLLIILVCYSLIIRALRRRSkqsqKSVRKRKALRMILIVLAVFLVCFLP 225
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
 51-164 1.74e-03

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 38.64  E-value: 1.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  51 VTESGILLVMSFDRYVAICNPLRYATVLTDARVARMGMSVIIRSFCTVFPMPVLLKRLTFcKNNVLSHAYCL-HPDLIRL 129
Cdd:cd15339   84 FACSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKVIKF-RDGLESCAFNLtSPDDVLW 162

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 599412867 130 pcgditinniFGLSIVISTFGVDSALILLSYVLIL 164
Cdd:cd15339  163 ----------YTLYQTITTFFFPLPLILICYILIL 187
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
 39-86 2.23e-03

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 38.30  E-value: 2.23e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 599412867  39 CMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATVLTDARVARM 86
Cdd:cd15055   73 CKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKIC 120
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
 1-100 5.20e-03

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 37.19  E-value: 5.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   1 HQPMYIL---LSLNDLGVSFSTLPTVLATFCFHLRKISFDSCMAQMFFIHFFSVTESGILLVMSFDRYVAICNPLRYATV 77
Cdd:cd14969   32 RTPLNLFllnLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVSISTLAALAFERYLVIVRPLKAFRL 111

                         90       100
                 ....*....|....*....|...
gi 599412867  78 LTDARVARMGMSVIIRSFCTVFP 100
Cdd:cd14969  112 SKRRALILIAFIWLYGLFWALPP 134
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
 57-189 6.56e-03

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 37.02  E-value: 6.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867  57 LLVMSFDRYVAICNPLRYATVLTdarvARMGMSVIIRSFCTVFPMPVLLKRLTFCKNNVLSHAYCLHPDlirlPCG-DIT 135
Cdd:cd15057   91 LCVISVDRYWAISSPFRYERRMT----RRRAFIMIAVAWTLSALISFIPVQLGWHRADDTSEALALYAD----PCQcDSS 162

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 599412867 136 INNIFGLSIVISTFGVDSALILLSYVLILRSVLAIAsweERLKTLNTCVSHMCA 189
Cdd:cd15057  163 LNRTYAISSSLISFYIPVAIMIVTYTRIYRIARRQI---RRIAALERAAQESTN 213
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
 5-82 6.61e-03

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 36.83  E-value: 6.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412867   5 YILLSLN--DLGVSFSTLP---TVLATFCfhlrkISFDSCMaqmFFIHFFSV-TESGI--LLVMSFDRYVAICNPLRYAT 76
Cdd:cd15069   37 YFLVSLAaaDVAVGLFAIPfaiTISLGFC-----TDFHSCL---FLACFVLVlTQSSIfsLLAVAVDRYLAIKVPLRYKS 108


                 ....*.
gi 599412867  77 VLTDAR 82
Cdd:cd15069  109 LVTGKR 114
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
 49-82 9.22e-03

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 36.66  E-value: 9.22e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 599412867  49 FSVTES-GILLVMSFDRYVAICNPLRYATVLTDAR 82
Cdd:cd15058   82 LCVTASiETLCVIAVDRYIAITRPLRYQVLLTKRR 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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