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Conserved domains on  [gi|663499738|gb|AIE90656|]
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hypothetical protein [uncultured marine group II/III euryarchaeote AD1000_04_H03]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zn-ribbon_8 pfam09723
Zinc ribbon domain; This entry represents a region of about 41 amino acids found in a number ...
 760-789 9.98e-05

Zinc ribbon domain; This entry represents a region of about 41 amino acids found in a number of small proteins in a wide range of bacteria. The region usually begins with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One protein in this entry has been noted as a putative regulatory protein, designated FmdB. Most proteins in this entry have a C-terminal region containing highly degenerate sequence.


:

Pssm-ID: 462856  Cd Length: 41  Bit Score: 40.28  E-value: 9.98e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 663499738  760 CSSCDKKFEVELPSGvDAARTACPHCGSIE 789
Cdd:pfam09723   8 CEECGHEFEVLQKIS-DPPLTTCPECGSGD 36
REJ super family cl28747
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 271-479 2.09e-04

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


The actual alignment was detected with superfamily member pfam02010:

Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 44.41  E-value: 2.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663499738  271 TEDIaVTVTLSLTPvLEPVISGGvSLEMINVGDIVTLDATQT-----PNNSGQIPEsgFHW-----------DTNGDGVD 334
Cdd:pfam02010  71 GTDI-ITVTVQPSP-LVAVIDGG-SSRVVGYNQDLTLDGSESydpdvDPGSSSGLT--YLWscrrsssgdnpLLNNDPVC 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663499738  335 DTAGSSVNVSWSGPTNVTI-------------RLTVVATDGRSASAYQSIEIADISAPEVSIGASSVLERSFG--DDVVL 399
Cdd:pfam02010 146 FSDQNEGTLLQSTSSSLTIpastlqanvtytfKLTVSKGSRNSASTTQTILVVDGNPPIIILSCISNCNRKNNpvDRLVL 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663499738  400 SAVVSDNWGI----ATIEW---------LVDDVLMrSNAGTDEGAT---VFSHLFNS--SYtagphTITLRVTDNSGLaS 461
Cdd:pfam02010 226 LASTCLNCSSdlsdVTYRWlslgsentsLVLDQLN-SQTSTGRSGPylvIKAGVLQSgvSY-----RFTLIVTVYPGL-V 298

                         250
                  ....*....|....*...
gi 663499738  462 EDSAAISLYDSTPPVIGT 479
Cdd:pfam02010 299 SGLASISFITNAPPTGGT 316
DUF4625 super family cl21244
Domain of unknown function (DUF4625); This family contains a likely bacterial Ig-like fold, ...
 471-540 8.98e-03

Domain of unknown function (DUF4625); This family contains a likely bacterial Ig-like fold, suggesting it may be a family of lipoproteins.


The actual alignment was detected with superfamily member pfam15418:

Pssm-ID: 405993  Cd Length: 131  Bit Score: 37.36  E-value: 8.98e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 663499738  471 DSTPPVI------GTHQEELELQVGQTFRFEANVSDaesNNLLFSwdFQGDVDSNSDGDPRNDGDGFGDsVLWSFE 540
Cdd:pfam15418  10 DTTKPVIslietgAFPSNCEVLKIGDTFHFEAVISD---NVALAS--YKIDIHNNFDHHSHDSEAAEGE-KPWSFE 79
 
Name Accession Description Interval E-value
Zn-ribbon_8 pfam09723
Zinc ribbon domain; This entry represents a region of about 41 amino acids found in a number ...
 760-789 9.98e-05

Zinc ribbon domain; This entry represents a region of about 41 amino acids found in a number of small proteins in a wide range of bacteria. The region usually begins with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One protein in this entry has been noted as a putative regulatory protein, designated FmdB. Most proteins in this entry have a C-terminal region containing highly degenerate sequence.


Pssm-ID: 462856  Cd Length: 41  Bit Score: 40.28  E-value: 9.98e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 663499738  760 CSSCDKKFEVELPSGvDAARTACPHCGSIE 789
Cdd:pfam09723   8 CEECGHEFEVLQKIS-DPPLTTCPECGSGD 36
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 271-479 2.09e-04

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 44.41  E-value: 2.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663499738  271 TEDIaVTVTLSLTPvLEPVISGGvSLEMINVGDIVTLDATQT-----PNNSGQIPEsgFHW-----------DTNGDGVD 334
Cdd:pfam02010  71 GTDI-ITVTVQPSP-LVAVIDGG-SSRVVGYNQDLTLDGSESydpdvDPGSSSGLT--YLWscrrsssgdnpLLNNDPVC 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663499738  335 DTAGSSVNVSWSGPTNVTI-------------RLTVVATDGRSASAYQSIEIADISAPEVSIGASSVLERSFG--DDVVL 399
Cdd:pfam02010 146 FSDQNEGTLLQSTSSSLTIpastlqanvtytfKLTVSKGSRNSASTTQTILVVDGNPPIIILSCISNCNRKNNpvDRLVL 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663499738  400 SAVVSDNWGI----ATIEW---------LVDDVLMrSNAGTDEGAT---VFSHLFNS--SYtagphTITLRVTDNSGLaS 461
Cdd:pfam02010 226 LASTCLNCSSdlsdVTYRWlslgsentsLVLDQLN-SQTSTGRSGPylvIKAGVLQSgvSY-----RFTLIVTVYPGL-V 298

                         250
                  ....*....|....*...
gi 663499738  462 EDSAAISLYDSTPPVIGT 479
Cdd:pfam02010 299 SGLASISFITNAPPTGGT 316
CxxC_CXXC_SSSS smart00834
Putative regulatory protein; CxxC_CXXC_SSSS represents a region of about 41 amino acids found ...
 760-787 2.36e-04

Putative regulatory protein; CxxC_CXXC_SSSS represents a region of about 41 amino acids found in a number of small proteins in a wide range of bacteria. The region usually begins with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One protein in this entry has been noted as a putative regulatory protein, designated FmdB. Most proteins in this entry have a C-terminal region containing highly degenerate sequence.


Pssm-ID: 197903  Cd Length: 41  Bit Score: 39.08  E-value: 2.36e-04
                           10        20
                   ....*....|....*....|....*...
gi 663499738   760 CSSCDKKFEVeLPSGVDAARTACPHCGS 787
Cdd:smart00834   8 CEDCGHTFEV-LQKISDDPLTTCPECGG 34
CxxC_CxxC_SSSS TIGR02605
putative regulatory protein, FmdB family; This model represents a region of about 50 amino ...
 760-787 1.61e-03

putative regulatory protein, FmdB family; This model represents a region of about 50 amino acids found in a number of small proteins in a wide range of bacteria. The region begins usually with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One member of this family is has been noted as a putative regulatory protein, designated FmdB (SP:Q50229, ). Most members of this family have a C-terminal region containing highly degenerate sequence, such as SSTSESTKSSGSSGSSGSSESKASGSTEKSTSSTTAAAAV in Mycobacterium tuberculosis and VAVGGSAPAPSPAPRAGGGGGGCCGGGCCG in Streptomyces avermitilis. These low complexity regions, which are not included in the model, resemble low-complexity C-terminal regions of some heterocycle-containing bacteriocin precursors. [Regulatory functions, DNA interactions]


Pssm-ID: 274226  Cd Length: 52  Bit Score: 37.32  E-value: 1.61e-03
                          10        20
                  ....*....|....*....|....*...
gi 663499738  760 CSSCDKKFEVeLPSGVDAARTACPHCGS 787
Cdd:TIGR02605   8 CTACGHRFEV-LQKMSDDPLATCPACGG 34
COG2331 COG2331
Predicted nucleic acid-binding protein, contains Zn-ribbon domain [General function prediction ...
 760-787 6.31e-03

Predicted nucleic acid-binding protein, contains Zn-ribbon domain [General function prediction only];


Pssm-ID: 441902  Cd Length: 77  Bit Score: 36.18  E-value: 6.31e-03
                         10        20
                 ....*....|....*....|....*...
gi 663499738 760 CSSCDKKFEVELPSGvDAARTACPHCGS 787
Cdd:COG2331    8 CESCGHEFEVLQKMS-DDPLTVCPECGG 34
DUF4625 pfam15418
Domain of unknown function (DUF4625); This family contains a likely bacterial Ig-like fold, ...
 471-540 8.98e-03

Domain of unknown function (DUF4625); This family contains a likely bacterial Ig-like fold, suggesting it may be a family of lipoproteins.


Pssm-ID: 405993  Cd Length: 131  Bit Score: 37.36  E-value: 8.98e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 663499738  471 DSTPPVI------GTHQEELELQVGQTFRFEANVSDaesNNLLFSwdFQGDVDSNSDGDPRNDGDGFGDsVLWSFE 540
Cdd:pfam15418  10 DTTKPVIslietgAFPSNCEVLKIGDTFHFEAVISD---NVALAS--YKIDIHNNFDHHSHDSEAAEGE-KPWSFE 79
 
Name Accession Description Interval E-value
Zn-ribbon_8 pfam09723
Zinc ribbon domain; This entry represents a region of about 41 amino acids found in a number ...
 760-789 9.98e-05

Zinc ribbon domain; This entry represents a region of about 41 amino acids found in a number of small proteins in a wide range of bacteria. The region usually begins with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One protein in this entry has been noted as a putative regulatory protein, designated FmdB. Most proteins in this entry have a C-terminal region containing highly degenerate sequence.


Pssm-ID: 462856  Cd Length: 41  Bit Score: 40.28  E-value: 9.98e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 663499738  760 CSSCDKKFEVELPSGvDAARTACPHCGSIE 789
Cdd:pfam09723   8 CEECGHEFEVLQKIS-DPPLTTCPECGSGD 36
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 271-479 2.09e-04

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 44.41  E-value: 2.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663499738  271 TEDIaVTVTLSLTPvLEPVISGGvSLEMINVGDIVTLDATQT-----PNNSGQIPEsgFHW-----------DTNGDGVD 334
Cdd:pfam02010  71 GTDI-ITVTVQPSP-LVAVIDGG-SSRVVGYNQDLTLDGSESydpdvDPGSSSGLT--YLWscrrsssgdnpLLNNDPVC 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663499738  335 DTAGSSVNVSWSGPTNVTI-------------RLTVVATDGRSASAYQSIEIADISAPEVSIGASSVLERSFG--DDVVL 399
Cdd:pfam02010 146 FSDQNEGTLLQSTSSSLTIpastlqanvtytfKLTVSKGSRNSASTTQTILVVDGNPPIIILSCISNCNRKNNpvDRLVL 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663499738  400 SAVVSDNWGI----ATIEW---------LVDDVLMrSNAGTDEGAT---VFSHLFNS--SYtagphTITLRVTDNSGLaS 461
Cdd:pfam02010 226 LASTCLNCSSdlsdVTYRWlslgsentsLVLDQLN-SQTSTGRSGPylvIKAGVLQSgvSY-----RFTLIVTVYPGL-V 298

                         250
                  ....*....|....*...
gi 663499738  462 EDSAAISLYDSTPPVIGT 479
Cdd:pfam02010 299 SGLASISFITNAPPTGGT 316
CxxC_CXXC_SSSS smart00834
Putative regulatory protein; CxxC_CXXC_SSSS represents a region of about 41 amino acids found ...
 760-787 2.36e-04

Putative regulatory protein; CxxC_CXXC_SSSS represents a region of about 41 amino acids found in a number of small proteins in a wide range of bacteria. The region usually begins with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One protein in this entry has been noted as a putative regulatory protein, designated FmdB. Most proteins in this entry have a C-terminal region containing highly degenerate sequence.


Pssm-ID: 197903  Cd Length: 41  Bit Score: 39.08  E-value: 2.36e-04
                           10        20
                   ....*....|....*....|....*...
gi 663499738   760 CSSCDKKFEVeLPSGVDAARTACPHCGS 787
Cdd:smart00834   8 CEDCGHTFEV-LQKISDDPLTTCPECGG 34
Big_7 pfam17957
Bacterial Ig domain; This entry represents a bacterial ig-like domain that is found in ...
 394-450 6.26e-04

Bacterial Ig domain; This entry represents a bacterial ig-like domain that is found in glycosyl hydrolase enzymes.


Pssm-ID: 436171 [Multi-domain]  Cd Length: 67  Bit Score: 38.74  E-value: 6.26e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 663499738  394 GDDVVLSAVVSDNWGIATIEWLVDDVLMrsnaGTDEGATvFSHLFN-SSYTAGPHTIT 450
Cdd:pfam17957  14 GGTVTISATASDDGGVSKVEFYVDGTLV----GTDTSAP-YSFTWTtTALANGTHTIT 66
CxxC_CxxC_SSSS TIGR02605
putative regulatory protein, FmdB family; This model represents a region of about 50 amino ...
 760-787 1.61e-03

putative regulatory protein, FmdB family; This model represents a region of about 50 amino acids found in a number of small proteins in a wide range of bacteria. The region begins usually with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One member of this family is has been noted as a putative regulatory protein, designated FmdB (SP:Q50229, ). Most members of this family have a C-terminal region containing highly degenerate sequence, such as SSTSESTKSSGSSGSSGSSESKASGSTEKSTSSTTAAAAV in Mycobacterium tuberculosis and VAVGGSAPAPSPAPRAGGGGGGCCGGGCCG in Streptomyces avermitilis. These low complexity regions, which are not included in the model, resemble low-complexity C-terminal regions of some heterocycle-containing bacteriocin precursors. [Regulatory functions, DNA interactions]


Pssm-ID: 274226  Cd Length: 52  Bit Score: 37.32  E-value: 1.61e-03
                          10        20
                  ....*....|....*....|....*...
gi 663499738  760 CSSCDKKFEVeLPSGVDAARTACPHCGS 787
Cdd:TIGR02605   8 CTACGHRFEV-LQKMSDDPLATCPACGG 34
COG2331 COG2331
Predicted nucleic acid-binding protein, contains Zn-ribbon domain [General function prediction ...
 760-787 6.31e-03

Predicted nucleic acid-binding protein, contains Zn-ribbon domain [General function prediction only];


Pssm-ID: 441902  Cd Length: 77  Bit Score: 36.18  E-value: 6.31e-03
                         10        20
                 ....*....|....*....|....*...
gi 663499738 760 CSSCDKKFEVELPSGvDAARTACPHCGS 787
Cdd:COG2331    8 CESCGHEFEVLQKMS-DDPLTVCPECGG 34
DUF4625 pfam15418
Domain of unknown function (DUF4625); This family contains a likely bacterial Ig-like fold, ...
 471-540 8.98e-03

Domain of unknown function (DUF4625); This family contains a likely bacterial Ig-like fold, suggesting it may be a family of lipoproteins.


Pssm-ID: 405993  Cd Length: 131  Bit Score: 37.36  E-value: 8.98e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 663499738  471 DSTPPVI------GTHQEELELQVGQTFRFEANVSDaesNNLLFSwdFQGDVDSNSDGDPRNDGDGFGDsVLWSFE 540
Cdd:pfam15418  10 DTTKPVIslietgAFPSNCEVLKIGDTFHFEAVISD---NVALAS--YKIDIHNNFDHHSHDSEAAEGE-KPWSFE 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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