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Conserved domains on  [gi|663516473|gb|AIF06923|]
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tRNA/rRNA methyltransferase (spoU) [uncultured marine group II/III euryarchaeote KM3_196_G04]

Protein Classification

RNA methyltransferase( domain architecture ID 1000317)

SpoU family RNA methyltransferase catalyzes the methylation of rRNA or tRNA at specific sites in a S-adenosyl-L-methionine (SAM)-dependent manner

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPOUT_MTase super family cl38912
SPOUT superfamily of SAM-dependent RNA methyltransferases; The SPOUT (SpoU-TrmD) ...
 17-118 1.07e-21

SPOUT superfamily of SAM-dependent RNA methyltransferases; The SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, also known as class IV methyltransferase family, is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot. Members of the SPOUT superfamily that have been characterized functionally are involved in post-transcriptional RNA modification by catalyzing methylation of the 2-OH group of ribose, the N-1 atom of guanosine 37 in tRNA, or the N-3 atom of uridine 1498 in 16S rRNA.


The actual alignment was detected with superfamily member cd18092:

Pssm-ID: 476814  Cd Length: 162  Bit Score: 84.06  E-value: 1.07e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663516473  17 RISMKAHRFMPVH-WVDGDDLVAQAREAGFRIVALEDSGDTAPWDE-DLTGNVLLIVGGEHDGISDSILNASDSTIRVPM 94
Cdd:cd18092   59 GVAMGADKWLDVHrHDSTEECLAALKEQGYRIVATSLSPDAVPLDElDYTRPTALVFGNEKDGVSEEALAAADERVYIPM 138

                         90       100
                 ....*....|....*....|....
gi 663516473  95 AGFVPSYNLQAPMSIVSAEALRQR 118
Cdd:cd18092  139 YGFVESLNVSVAAAIILYELQRQR 162
 
Name Accession Description Interval E-value
SpoU-like_TrmH cd18092
SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group ...
 17-118 1.07e-21

SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the universally conserved guanosine 18 (G18) position in tRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349965  Cd Length: 162  Bit Score: 84.06  E-value: 1.07e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663516473  17 RISMKAHRFMPVH-WVDGDDLVAQAREAGFRIVALEDSGDTAPWDE-DLTGNVLLIVGGEHDGISDSILNASDSTIRVPM 94
Cdd:cd18092   59 GVAMGADKWLDVHrHDSTEECLAALKEQGYRIVATSLSPDAVPLDElDYTRPTALVFGNEKDGVSEEALAAADERVYIPM 138

                         90       100
                 ....*....|....*....|....
gi 663516473  95 AGFVPSYNLQAPMSIVSAEALRQR 118
Cdd:cd18092  139 YGFVESLNVSVAAAIILYELQRQR 162
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 14-119 3.08e-20

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 82.55  E-value: 3.08e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663516473  14 AAVRISMKAHRFMPVH-WVDGDDLVAQAREAGFRIVALEDSGDTAPWDEDLTGNVLLIVGGEHDGISDSILNASDSTIRV 92
Cdd:COG0566  157 KVVRASAGALFHVPVArVTNLADALEELKEAGFWVVGTDLDGEASLYEVDLPGPVALVLGNEGKGLSRLVLEACDELVRI 236

                         90       100
                 ....*....|....*....|....*..
gi 663516473  93 PMAGFVPSYNLQAPMSIVSAEALRQRS 119
Cdd:COG0566  237 PMAGGVESLNVAVAAAILLYEAARQRR 263
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 13-103 2.77e-16

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 69.48  E-value: 2.77e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663516473   13 KAAVRISMKAHRFMPVH-WVDGDDLVAQAREAGFRIVALeDSGDTAPWDEDLTGNVLLIVGGEHDGISDSILNASDSTIR 91
Cdd:pfam00588  43 PKAIRASAGALFHLPLVvVDNLEEALKDLKEAGYAVVAT-SLGGKSLYEIDFPKKVALVFGNEGTGLSNEVLELCDRLVR 121

                          90
                  ....*....|..
gi 663516473   92 VPMAGFVPSYNL 103
Cdd:pfam00588 122 IPMSGDVESLNV 133
rRNA_methyl_3 TIGR00186
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ...
 15-118 2.18e-10

rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129290 [Multi-domain]  Cd Length: 237  Bit Score: 55.81  E-value: 2.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663516473   15 AVRISMKAHRFMPVHWVDG-DDLVAQAREAGFRIVALEDSGDTAPWDEDLTGNVLLIVGGEHDGISDSILNASDSTIRVP 93
Cdd:TIGR00186 133 VVKTSSGAVEYVPLARVTNlSRTITKLKESGFWTVGTDLDAQDTLYQVKLTKPLALVVGNEGEGVSRLIKENCDFLIKIP 212

                          90       100
                  ....*....|....*....|....*
gi 663516473   94 MAGFVPSYNLQAPMSIVSAEALRQR 118
Cdd:TIGR00186 213 MAGKVDSLNVSVAAGILLFEIKRQR 237
PRK10864 PRK10864
putative methyltransferase; Provisional
 28-119 2.48e-09

putative methyltransferase; Provisional


Pssm-ID: 236779 [Multi-domain]  Cd Length: 346  Bit Score: 53.24  E-value: 2.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663516473  28 VHWVDGDDLV---AQAREAGFRIVALEDSGDTAPWDEDLTGNVLLIVGGEHDGISDSILNASDSTIRVPMAGFVPSYNLQ 104
Cdd:PRK10864 251 VQPITGDSFVdvlDDFRQAGYTIVTTSSHKGTPLFKASLPAKMVLVLGQEYDGLSDAARQQGDLSVSIDGTGNVESLNVS 330

                         90
                 ....*....|....*
gi 663516473 105 APMSIVSAEALRQRS 119
Cdd:PRK10864 331 VATGVLLAEWWRQNK 345
 
Name Accession Description Interval E-value
SpoU-like_TrmH cd18092
SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group ...
 17-118 1.07e-21

SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the universally conserved guanosine 18 (G18) position in tRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349965  Cd Length: 162  Bit Score: 84.06  E-value: 1.07e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663516473  17 RISMKAHRFMPVH-WVDGDDLVAQAREAGFRIVALEDSGDTAPWDE-DLTGNVLLIVGGEHDGISDSILNASDSTIRVPM 94
Cdd:cd18092   59 GVAMGADKWLDVHrHDSTEECLAALKEQGYRIVATSLSPDAVPLDElDYTRPTALVFGNEKDGVSEEALAAADERVYIPM 138

                         90       100
                 ....*....|....*....|....
gi 663516473  95 AGFVPSYNLQAPMSIVSAEALRQR 118
Cdd:cd18092  139 YGFVESLNVSVAAAIILYELQRQR 162
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 14-119 3.08e-20

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 82.55  E-value: 3.08e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663516473  14 AAVRISMKAHRFMPVH-WVDGDDLVAQAREAGFRIVALEDSGDTAPWDEDLTGNVLLIVGGEHDGISDSILNASDSTIRV 92
Cdd:COG0566  157 KVVRASAGALFHVPVArVTNLADALEELKEAGFWVVGTDLDGEASLYEVDLPGPVALVLGNEGKGLSRLVLEACDELVRI 236

                         90       100
                 ....*....|....*....|....*..
gi 663516473  93 PMAGFVPSYNLQAPMSIVSAEALRQRS 119
Cdd:COG0566  237 PMAGGVESLNVAVAAAILLYEAARQRR 263
SpoU-like_rRNA-MTase cd18095
SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 14-102 7.50e-19

SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349968  Cd Length: 143  Bit Score: 75.93  E-value: 7.50e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663516473  14 AAVRISMKAHRFMPVHWVDG-DDLVAQAREAGFRIVALEDSGDTAPWDEDLTGNVLLIVGGEHDGISDSILNASDSTIRV 92
Cdd:cd18095   42 KVVRASMGALFRLPIIRVDDlEELLEELKEAGYKVVAADLDGGSSLYDLDLPKPVALVLGNEGNGLSDELLELCDKRVTI 121

                         90
                 ....*....|
gi 663516473  93 PMAGFVPSYN 102
Cdd:cd18095  122 PMSGGVESLN 131
SpoU-like_RNA-MTase cd18104
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 15-118 9.10e-18

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349977  Cd Length: 146  Bit Score: 73.38  E-value: 9.10e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663516473  15 AVRISMKAHRFMPVHWVDGDDLVAQAREAGFRIVALEDSGDTAPWDEDLTGNVLLIVGGEHDGISDSILNASDSTIRVPM 94
Cdd:cd18104   43 VIRASLGAVFTLPVAEASSEETLAWLKENKIRILATTPKAEKLYYEADLRGPIAIVVGSESEGLSEFWLKAADERVRIPM 122

                         90       100
                 ....*....|....*....|....
gi 663516473  95 AGFVPSYNLQAPMSIVSAEALRQR 118
Cdd:cd18104  123 AGQADSLNVSVAAAILLYEALRQR 146
SpoU-like_RlmB cd18103
SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the ...
 41-102 6.40e-17

SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the methylation of guanosine 2251, a modification conserved in the peptidyltransferase domain of 23S rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349976  Cd Length: 143  Bit Score: 71.26  E-value: 6.40e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 663516473  41 REAGFRIVALEDSGDTAPWDEDLTGNVLLIVGGEHDGISDSILNASDSTIRVPMAGFVPSYN 102
Cdd:cd18103   70 KEAGFWIYGADGEAEKSLYDVDLTGPLALVLGSEGKGLRRLVLKNCDFLVKIPMAGKVDSLN 131
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 13-103 2.77e-16

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 69.48  E-value: 2.77e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663516473   13 KAAVRISMKAHRFMPVH-WVDGDDLVAQAREAGFRIVALeDSGDTAPWDEDLTGNVLLIVGGEHDGISDSILNASDSTIR 91
Cdd:pfam00588  43 PKAIRASAGALFHLPLVvVDNLEEALKDLKEAGYAVVAT-SLGGKSLYEIDFPKKVALVFGNEGTGLSNEVLELCDRLVR 121

                          90
                  ....*....|..
gi 663516473   92 VPMAGFVPSYNL 103
Cdd:pfam00588 122 IPMSGDVESLNV 133
SpoU-like cd18097
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 11-114 2.35e-15

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349970  Cd Length: 144  Bit Score: 67.20  E-value: 2.35e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663516473  11 DRKAAvRISMKAHRFMPV-HWVDGDDLVAQAREAGFRIVALEDSGDTAPWDE-DLTGNVLLIVGGEHDGISDSILNASDS 88
Cdd:cd18097   40 HPKVA-KTALGAEESVPWeHFEDTLEAVRALKARGYTIIALETTENSVPLHEaRLPRPLALVLGNEVRGVSPEVLALCDA 118

                         90       100
                 ....*....|....*....|....*.
gi 663516473  89 TIRVPMAGFVPSYNLQAPMSIVSAEA 114
Cdd:cd18097  119 VVEIPMFGRKNSLNVAVAAAVALYEL 144
SpoU-like_family cd18082
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 15-114 4.34e-13

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349955  Cd Length: 145  Bit Score: 61.47  E-value: 4.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663516473  15 AVRISMKAHRFMPVHWVDG-DDLVAQAREAGFRIVALE-DSGDTAPWD--EDLTGNVLLIVGGEHDGISDSILNASDSTI 90
Cdd:cd18082   42 AKRTSRGTHFSVPYERVDNfEEYLKSLKEEGYPLIGLElTDGSIPLSEfkFKKPKKIALIFGNERSGLSPELLALCDYTV 121

                         90       100
                 ....*....|....*....|....
gi 663516473  91 RVPMAGFVPSYNLQAPMSIVSAEA 114
Cdd:cd18082  122 HIPMSGKNSSLNVSVATGIALYEF 145
SpoU-like_TrmL cd18094
SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL ...
 28-117 2.73e-11

SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 34 in both tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349967  Cd Length: 145  Bit Score: 56.69  E-value: 2.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663516473  28 VHWVDGDDLVAQAREAgfRIVALEDSGDTAPWDEDLTGNVLLIVGGEHDGISDSILNA-SDSTIRVPMAGFVPSYNLQAP 106
Cdd:cd18094   56 TVHDSWEAFLEALPPG--RLFLFTTKGTKPYTDFDFKPGDYLVFGRESTGLPEEILDAfPDRRLRIPMRPKVRSLNLSNS 133

                         90
                 ....*....|.
gi 663516473 107 MSIVSAEALRQ 117
Cdd:cd18094  134 VAIVLYEALRQ 144
SpoU-like_AviRb cd18107
SAM-dependent rRNA methylase related to AviRb; AviRb from Streptomyces viridochromogenes ...
 14-114 1.96e-10

SAM-dependent rRNA methylase related to AviRb; AviRb from Streptomyces viridochromogenes methylates the 2'-O atom of U2479 of the 23S ribosomal RNA. AviRb is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349980  Cd Length: 148  Bit Score: 54.32  E-value: 1.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663516473  14 AAVRISMKAHRFMPVHWVDG----DDLVAQAREAG--FRIVALEDSGDTAPWDEDLTGNVLLIVGGEHDGISDSILNASD 87
Cdd:cd18107   42 KTIRASTGSLFSLPIVRVPSnrelEDWVEARKARGtpLQLVGTDEHGDHQIADHDFTRPTLLLIGNETAGLSAAWRELCD 121

                         90       100
                 ....*....|....*....|....*..
gi 663516473  88 STIRVPMAGFVPSYNLQAPMSIVSAEA 114
Cdd:cd18107  122 ETVSIPMAGSASSLNAACAASIFLYEA 148
rRNA_methyl_3 TIGR00186
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ...
 15-118 2.18e-10

rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129290 [Multi-domain]  Cd Length: 237  Bit Score: 55.81  E-value: 2.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663516473   15 AVRISMKAHRFMPVHWVDG-DDLVAQAREAGFRIVALEDSGDTAPWDEDLTGNVLLIVGGEHDGISDSILNASDSTIRVP 93
Cdd:TIGR00186 133 VVKTSSGAVEYVPLARVTNlSRTITKLKESGFWTVGTDLDAQDTLYQVKLTKPLALVVGNEGEGVSRLIKENCDFLIKIP 212

                          90       100
                  ....*....|....*....|....*
gi 663516473   94 MAGFVPSYNLQAPMSIVSAEALRQR 118
Cdd:TIGR00186 213 MAGKVDSLNVSVAAGILLFEIKRQR 237
PRK10864 PRK10864
putative methyltransferase; Provisional
 28-119 2.48e-09

putative methyltransferase; Provisional


Pssm-ID: 236779 [Multi-domain]  Cd Length: 346  Bit Score: 53.24  E-value: 2.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663516473  28 VHWVDGDDLV---AQAREAGFRIVALEDSGDTAPWDEDLTGNVLLIVGGEHDGISDSILNASDSTIRVPMAGFVPSYNLQ 104
Cdd:PRK10864 251 VQPITGDSFVdvlDDFRQAGYTIVTTSSHKGTPLFKASLPAKMVLVLGQEYDGLSDAARQQGDLSVSIDGTGNVESLNVS 330

                         90
                 ....*....|....*
gi 663516473 105 APMSIVSAEALRQRS 119
Cdd:PRK10864 331 VATGVLLAEWWRQNK 345
PRK11081 PRK11081
tRNA guanosine-2'-O-methyltransferase; Provisional
 29-118 1.83e-07

tRNA guanosine-2'-O-methyltransferase; Provisional


Pssm-ID: 236837 [Multi-domain]  Cd Length: 229  Bit Score: 47.68  E-value: 1.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663516473  29 HWVDG------DDLVAQAREAGFRIVALEDSGDTAPWDE-DLTGNVLLIVGGEHDGISDSILNASDSTIRVPMAGFVPSY 101
Cdd:PRK11081  69 SWVQVkthrtiGDAVAHLKGQGMQILATHLSDTAVDFREiDYTRPTCILMGQEKTGISQEALALADQDIIIPMIGMVQSL 148

                         90
                 ....*....|....*..
gi 663516473 102 NLQAPMSIVSAEALRQR 118
Cdd:PRK11081 149 NVSVASALILYEAQRQR 165
TrmL COG0219
tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ...
 28-117 2.10e-07

tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ribosomal structure and biogenesis]; tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 439989  Cd Length: 153  Bit Score: 46.57  E-value: 2.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663516473  28 VHWVDGDDLVAQAREAgfRIVALEDSGDTAPWDEDLTGNVLLIVGGEHDGISDSILNA-SDSTIRVPMAGFVPSYNLQAP 106
Cdd:COG0219   58 TVHDSWEAFLEALPGG--RLFLFTTKGTKPYTDVDYQPGDVLLFGRETAGLPEEVLAApADQRLRIPMRPGVRSLNLSNA 135

                         90
                 ....*....|.
gi 663516473 107 MSIVSAEALRQ 117
Cdd:COG0219  136 VAIVLYEALRQ 146
SpoU-like_MRM1 cd18105
SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose ...
 25-100 6.39e-07

SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose residues G1145 to GmG residue of the mitochondrial 16S rRNA. MRM1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349978  Cd Length: 158  Bit Score: 45.20  E-value: 6.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663516473  25 FMPVHWVDgdDL---VAQAREAGFRIVALEDSGDTAPW----------DEDLTGNVLLIVGGEHDGISDSILNASDSTIR 91
Cdd:cd18105   53 LMPIYSVD--NLasfLKSSKENGWKVVGTSAPPSASSDkktipanelsELLLEKPTILVLGNEGRGLRTNIKNLCDYLVS 130


                 ....*....
gi 663516473  92 VPMAGFVPS 100
Cdd:cd18105  131 IPGGRSAEN 139
PRK11181 PRK11181
23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;
42-119 6.01e-06

23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;


Pssm-ID: 183021 [Multi-domain]  Cd Length: 244  Bit Score: 43.42  E-value: 6.01e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 663516473  42 EAGFRIVALEDSGDTAPWDEDLTGNVLLIVGGEHDGISDSILNASDSTIRVPMAGFVPSYNLQAPMSIVSAEALRQRS 119
Cdd:PRK11181 166 EKNIWIVGTAGEADHTLYQSKLTGPLALVMGAEGEGMRRLTREHCDELISIPMAGSVSSLNVSVATGICLFEAVRQRS 243
PRK10358 PRK10358
tRNA (uridine(34)/cytosine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase ...
 11-117 3.32e-04

tRNA (uridine(34)/cytosine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase TrmL;


Pssm-ID: 182406  Cd Length: 157  Bit Score: 38.05  E-value: 3.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663516473  11 DRKAAVRISMKAHRFMPV-HWVDGDDLVAQarEAGFRIVALEDSGDTAPWDEDLTGNVLLIVGGEHDGISDSILNA--SD 87
Cdd:PRK10358  40 DDKRLRRAGLDYHEFTAVtRHHDYAAFLEA--ENPQRLFALTTKGTPAHSAVSYQDGDYLMFGPETRGLPASILDAlpAE 117

                         90       100       110
                 ....*....|....*....|....*....|
gi 663516473  88 STIRVPMAGFVPSYNLQAPMSIVSAEALRQ 117
Cdd:PRK10358 118 QKIRIPMMPDSRSMNLSNAVSVVVYEAWRQ 147
SpoU-like_RNMTL1 cd18106
SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) ...
 17-114 5.02e-04

SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) catalyzes the methylation of 2'-O-ribose residues G1370 to GmG residue of the mitochondrial 16S rRNA. RNMTL1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349979  Cd Length: 148  Bit Score: 37.23  E-value: 5.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663516473  17 RISMKAHRFMP----VHWvdgdDLVAQAREAGFRIVALEDSGDTAPWDEDLT--GNVLLIVGGEHDGISDSILNASDST- 89
Cdd:cd18106   45 RAGAGAHFRLPiygnLSW----DDIPNYLPDDSKVFLADNNLPVQPYDSIDYcsGPIVLVIGGETHGVSPEAYKLAHSTg 120

                         90       100
                 ....*....|....*....|....*...
gi 663516473  90 ---IRVPMAGFVPSYNLQAPMSIVSAEA 114
Cdd:cd18106  121 gsrVHIPLANGVDSLNSAVAASILLFEM 148
SpoU-like cd18098
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 21-110 6.55e-04

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349971  Cd Length: 138  Bit Score: 36.86  E-value: 6.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663516473  21 KAHRFMPVHWVDGDDLVAQAREAGFRIVALEdSGDTApwdEDLTG-----NVLLIVGGEHDGISDSILNASDSTIRVPMA 95
Cdd:cd18098   47 KAWRHIPLFHYDDLEDLAEPLPFGAVLVAVE-LTEGA---TPLPDfkhpdRAVYLLGPEDGGLPQEVLARCHHVVYLPTR 122

                         90
                 ....*....|....*
gi 663516473  96 GfvpSYNLQAPMSIV 110
Cdd:cd18098  123 G---SLNVAVAGSIV 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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