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Conserved domains on  [gi|663526258|gb|AIF16437|]
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adenine-specific DNA methylase [uncultured marine group II/III euryarchaeote KM3_74_C08]

Protein Classification

TRM11 family methyltransferase( domain architecture ID 11437146)

TRM11 family SAM-dependent methyltransferase containing a THUMP domain, similar to fungal tRNA (guanine(10)-N2)-methyltransferase, the catalytic subunit of a tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 27-114 2.30e-16

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 76.53  E-value: 2.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663526258  27 YPAMMIPQVARGLVDLYG-NEGGILFDPYCGTGTSLVEARLAGMDGIGTDINPtaRMIAFAKTtdyNLKRLTGATEKV-- 103
Cdd:COG1041    6 YPGSLDPRLARALVNLAGaKEGDTVLDPFCGTGTILIEAGLLGRRVIGSDIDP--KMVEGARE---NLEHYGYEDADVir 80

                         90
                 ....*....|....*.
gi 663526258 104 -----LSYLEENLDSI 114
Cdd:COG1041   81 gdardLPLADESVDAI 96
 
Name Accession Description Interval E-value
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 27-114 2.30e-16

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 76.53  E-value: 2.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663526258  27 YPAMMIPQVARGLVDLYG-NEGGILFDPYCGTGTSLVEARLAGMDGIGTDINPtaRMIAFAKTtdyNLKRLTGATEKV-- 103
Cdd:COG1041    6 YPGSLDPRLARALVNLAGaKEGDTVLDPFCGTGTILIEAGLLGRRVIGSDIDP--KMVEGARE---NLEHYGYEDADVir 80

                         90
                 ....*....|....*.
gi 663526258 104 -----LSYLEENLDSI 114
Cdd:COG1041   81 gdardLPLADESVDAI 96
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 20-95 7.00e-06

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 46.19  E-value: 7.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663526258   20 YTHCFHiyPAMMIPQVARGLVDLYG-NEGGILFDPYCGTGTSLVEARLAGMDGI-------------GTDINPtaRMIAF 85
Cdd:pfam01170   3 YRPFNG--PAPLKETLAAAMVNLAGwKPGDPLLDPMCGSGTILIEAALMGANIApgkfdarvraplyGSDIDR--RMVQG 78

                          90
                  ....*....|
gi 663526258   86 AKTtdyNLKR 95
Cdd:pfam01170  79 ARL---NAEN 85
 
Name Accession Description Interval E-value
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 27-114 2.30e-16

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 76.53  E-value: 2.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663526258  27 YPAMMIPQVARGLVDLYG-NEGGILFDPYCGTGTSLVEARLAGMDGIGTDINPtaRMIAFAKTtdyNLKRLTGATEKV-- 103
Cdd:COG1041    6 YPGSLDPRLARALVNLAGaKEGDTVLDPFCGTGTILIEAGLLGRRVIGSDIDP--KMVEGARE---NLEHYGYEDADVir 80

                         90
                 ....*....|....*.
gi 663526258 104 -----LSYLEENLDSI 114
Cdd:COG1041   81 gdardLPLADESVDAI 96
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
9-102 2.87e-08

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 54.16  E-value: 2.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663526258   9 DWDFRSADTKEYThcfhIYPAMMIPQVARGLVDLYGNEGGILFDPYCGTGTSLVEARLAGMDGIGTDINPTARMIAfakt 88
Cdd:COG0863  149 VWDIPGVTPKERK----GHPTQKPVELLERLILASSNPGDIVLDPFAGSGTTLVAAERLGRRFIGIEIDPEYVEVA---- 220

                         90
                 ....*....|....
gi 663526258  89 tdynLKRLTGATEK 102
Cdd:COG0863  221 ----RRRLEEATGL 230
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 20-95 7.00e-06

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 46.19  E-value: 7.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663526258   20 YTHCFHiyPAMMIPQVARGLVDLYG-NEGGILFDPYCGTGTSLVEARLAGMDGI-------------GTDINPtaRMIAF 85
Cdd:pfam01170   3 YRPFNG--PAPLKETLAAAMVNLAGwKPGDPLLDPMCGSGTILIEAALMGANIApgkfdarvraplyGSDIDR--RMVQG 78

                          90
                  ....*....|
gi 663526258   86 AKTtdyNLKR 95
Cdd:pfam01170  79 ARL---NAEN 85
N6_N4_Mtase pfam01555
DNA methylase; Members of this family are DNA methylases. The family contains both N-4 ...
 26-78 8.94e-06

DNA methylase; Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.


Pssm-ID: 396230 [Multi-domain]  Cd Length: 221  Bit Score: 46.62  E-value: 8.94e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 663526258   26 IYPAMMIPQVARGLVDLYGNEGGILFDPYCGTGTSLVEARLAGMDGIGTDINP 78
Cdd:pfam01555 161 KHPTQKPEALLERLILASTNPGDIVLDPFAGSGTTGAAAKELGRNFIGIEIEE 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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