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Conserved domains on  [gi|663528509|gb|AIF18546|]
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transcriptional regulator (asnC) [uncultured marine thaumarchaeote KM3_83_D12]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
2-137 9.57e-37

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 122.96  E-value: 9.57e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663528509   2 AKVDKIDQKILSELTNDSSISIPKLSEKINVNSSVVYSRIKRLVKKKLIERFTIEINDKELGFGVKSITGINMDSKQRDN 81
Cdd:COG1522    1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 663528509  82 VIQELFKIPGVREVSEVTGRFDILVTMHAENLGEMYRIVSDNIGKIQGVVGSESFI 137
Cdd:COG1522   81 FAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSF 136
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
2-137 9.57e-37

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 122.96  E-value: 9.57e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663528509   2 AKVDKIDQKILSELTNDSSISIPKLSEKINVNSSVVYSRIKRLVKKKLIERFTIEINDKELGFGVKSITGINMDSKQRDN 81
Cdd:COG1522    1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 663528509  82 VIQELFKIPGVREVSEVTGRFDILVTMHAENLGEMYRIVSDNIGKIQGVVGSESFI 137
Cdd:COG1522   81 FAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSF 136
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 5-106 7.54e-24

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 89.11  E-value: 7.54e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663528509     5 DKIDQKILSELTNDSSISIPKLSEKINVNSSVVYSRIKRLVKKKLIERFTIEINDKELGFGVKSITGINMDSKQR-DNVI 83
Cdd:smart00344   2 DEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDKlEEFL 81

                           90       100
                   ....*....|....*....|...
gi 663528509    84 QELFKIPGVREVSEVTGRFDILV 106
Cdd:smart00344  82 EKLEKLPEVEEVYLVTGDYDYLL 104
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-140 7.90e-14

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 64.35  E-value: 7.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663528509   1 MAKVDKIDQKILSELTNDSSISIPKLSEKINVNSSVVYSRIKRLVKKKLIERFTIEINDKELGFGVKSITGINMDS-KQR 79
Cdd:PRK11179   4 NYQIDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSaKDY 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 663528509  80 DNVIQELFKIPGVREVSEVTGRFDILVTMHAENLGEMYRIVSDNIGKIQGVVGSESFIEMK 140
Cdd:PRK11179  84 PSALAKLESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLISLQ 144
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 71-141 4.82e-11

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 55.22  E-value: 4.82e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 663528509   71 GINMDSKQR-DNVIQELFKIPGVREVSEVTGRFDILVTMHAENLGEMYRIVSDNIGKIQGVVGSESFIEMKT 141
Cdd:pfam01037   2 EVKLEPGHAlEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 5-52 7.16e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 33.81  E-value: 7.16e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 663528509   5 DKIDQKILSELtNDSSISIPKLSEKINVNSSVVYSRIKRLVKKKLIER 52
Cdd:cd00090    6 DPTRLRILRLL-LEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVES 52
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
2-137 9.57e-37

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 122.96  E-value: 9.57e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663528509   2 AKVDKIDQKILSELTNDSSISIPKLSEKINVNSSVVYSRIKRLVKKKLIERFTIEINDKELGFGVKSITGINMDSKQRDN 81
Cdd:COG1522    1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 663528509  82 VIQELFKIPGVREVSEVTGRFDILVTMHAENLGEMYRIVSDNIGKIQGVVGSESFI 137
Cdd:COG1522   81 FAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSF 136
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 5-106 7.54e-24

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 89.11  E-value: 7.54e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663528509     5 DKIDQKILSELTNDSSISIPKLSEKINVNSSVVYSRIKRLVKKKLIERFTIEINDKELGFGVKSITGINMDSKQR-DNVI 83
Cdd:smart00344   2 DEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDKlEEFL 81

                           90       100
                   ....*....|....*....|...
gi 663528509    84 QELFKIPGVREVSEVTGRFDILV 106
Cdd:smart00344  82 EKLEKLPEVEEVYLVTGDYDYLL 104
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-140 7.90e-14

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 64.35  E-value: 7.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663528509   1 MAKVDKIDQKILSELTNDSSISIPKLSEKINVNSSVVYSRIKRLVKKKLIERFTIEINDKELGFGVKSITGINMDS-KQR 79
Cdd:PRK11179   4 NYQIDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSaKDY 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 663528509  80 DNVIQELFKIPGVREVSEVTGRFDILVTMHAENLGEMYRIVSDNIGKIQGVVGSESFIEMK 140
Cdd:PRK11179  84 PSALAKLESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLISLQ 144
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 71-141 4.82e-11

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 55.22  E-value: 4.82e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 663528509   71 GINMDSKQR-DNVIQELFKIPGVREVSEVTGRFDILVTMHAENLGEMYRIVSDNIGKIQGVVGSESFIEMKT 141
Cdd:pfam01037   2 EVKLEPGHAlEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
5-44 5.30e-09

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 48.90  E-value: 5.30e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 663528509    5 DKIDQKILSELTNDSSISIPKLSEKINVNSSVVYSRIKRL 44
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRL 40
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
6-50 8.36e-08

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 45.89  E-value: 8.36e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 663528509    6 KIDQKILSELTNDSSISIPKLSEKINVNSSVVYSRIKRLVKKKLI 50
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
4-150 1.08e-07

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 48.60  E-value: 1.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663528509   4 VDKIDQKILSELTNDSSISIPKLSEKINVNSSVVYSRIKRLVKKKLIERFTIEINDKELGFGVKSITGINMDSKQRD--- 80
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDvfe 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 663528509  81 ---NVIQELFKIpgvREVSEVTGRFDILVTMHAENLGEMYRIVSDNIGKIQGVVGSESFIEMKtRTKQMSYML 150
Cdd:PRK11169  92 qfnAAVQKLEEI---QECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVME-EVKQTNRLV 160
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
10-52 2.35e-03

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 36.39  E-value: 2.35e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 663528509  10 KILSELTNDSSISIPKLSEKINVNSSVVYSRIKRLVKKKLIER 52
Cdd:COG3398  101 RILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVER 143
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 5-52 7.16e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 33.81  E-value: 7.16e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 663528509   5 DKIDQKILSELtNDSSISIPKLSEKINVNSSVVYSRIKRLVKKKLIER 52
Cdd:cd00090    6 DPTRLRILRLL-LEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVES 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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