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Conserved domains on  [gi|671355845|gb|AII77365|]
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DNA gyrase subunit A, partial [Bacillus subtilis subsp. subtilis]

Protein Classification

DNA gyrase subunit A family protein( domain architecture ID 1000081)

DNA gyrase subunit A (GyrA) forms a 2:2 heterotetrameric complex with GyrB to form gyrase, a type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state; may be partial

CATH:  1.10.268.10|3.90.199.10
PubMed:  11395412|9519293|17397985

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05560 super family cl35335
DNA gyrase subunit A; Validated
 1-291 0e+00

DNA gyrase subunit A; Validated


The actual alignment was detected with superfamily member PRK05560:

Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 678.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845   1 RDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSA 80
Cdd:PRK05560  35 RDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPA 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845  81 AAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAV 160
Cdd:PRK05560 115 AAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACLAL 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845 161 SENPDVTIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTsSGKERIIVTELPYQVNKAKLIEKIA 240
Cdd:PRK05560 195 IDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKAEIEEI-KGREAIIVTEIPYQVNKARLIEKIA 273

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 671355845 241 DLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTS 291
Cdd:PRK05560 274 ELVKEKKIEGISDLRDESDRDGMRIVIELKRDAVPEVVLNNLYKHTQLQTS 324
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 1-291 0e+00

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 678.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845   1 RDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSA 80
Cdd:PRK05560  35 RDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPA 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845  81 AAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAV 160
Cdd:PRK05560 115 AAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACLAL 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845 161 SENPDVTIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTsSGKERIIVTELPYQVNKAKLIEKIA 240
Cdd:PRK05560 195 IDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKAEIEEI-KGREAIIVTEIPYQVNKARLIEKIA 273

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 671355845 241 DLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTS 291
Cdd:PRK05560 274 ELVKEKKIEGISDLRDESDRDGMRIVIELKRDAVPEVVLNNLYKHTQLQTS 324
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-291 0e+00

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 665.20  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845   1 RDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSA 80
Cdd:COG0188   40 RDGLKPVHRRILYAMHELGLTPDKPYKKSARVVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPA 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845  81 AAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAV 160
Cdd:COG0188  120 AAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACIAL 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845 161 SENPDVTIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEKIA 240
Cdd:COG0188  200 IDNPDATIEELMEYIPGPDFPTGGIIVGREGIREAYETGRGSIRVRAKAEIEELKRGREQIVVTEIPYQVNKARLIEKIA 279

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 671355845 241 DLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTS 291
Cdd:COG0188  280 ELVKEKKIEGISDVRDESDRDGMRIVIELKRDANPEVVLNQLYKHTQLQTS 330
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 1-291 0e+00

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 593.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845    1 RDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSA 80
Cdd:TIGR01063  31 RDGLKPVHRRILYAMYELGLTPDKPYKKSARIVGDVMGKYHPHGDSAIYDTLVRMAQDFSLRYPLVDGQGNFGSIDGDPP 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845   81 AAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAV 160
Cdd:TIGR01063 111 AAMRYTEARLTKIAEELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLLVNGSSGIAVGMATNIPPHNLGEIIDALLAY 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845  161 SENPDVTIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEKIA 240
Cdd:TIGR01063 191 IDNPDISIQELLEVIKGPDFPTGGIILGRSGIRSAYETGRGSIVIRARAEIEEDSKGREAIIVTEIPYQVNKARLIEKIA 270

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 671355845  241 DLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTS 291
Cdd:TIGR01063 271 ELVREKKIEGISDIRDESDREGIRIVIELKRDAVAEVVLNNLYKQTQLQVS 321
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 1-291 0e+00

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 524.44  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845   1 RDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSA 80
Cdd:cd00187    9 RDGLKPVQRRILYAMFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNFGSRDGDDA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845  81 AAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAV 160
Cdd:cd00187   89 AAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLREVIDALRAL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845 161 SENPDVTIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEqTSSGKERIIVTELPYQVNKAKLIEKIA 240
Cdd:cd00187  169 IDNPEASIDELMEIIKGPDFPTGGIIEGRAGIREAYETGRGRYIIRGKYEIE-DDEGRNTIEITELPYQVNKAKLKEKIA 247

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 671355845 241 DLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTS 291
Cdd:cd00187  248 ELVKDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTT 298
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
1-291 5.14e-167

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 470.11  E-value: 5.14e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845    1 RDGLKPVHRRILYAMNDLgMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV-DGDS 79
Cdd:pfam00521   7 RDGLKPVQRRILYAMFEL-LNLDKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGSRiDGDK 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845   80 AAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLA 159
Cdd:pfam00521  86 DAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREIIDALIA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845  160 VSENPDVTIpeLMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQtssgKERIIVTELPYQVNKAKLIEKI 239
Cdd:pfam00521 166 LLDGPEATL--LMKYIMGPDFPTGGGIIGKGGIKEAYKTGRGKITVRAKVEIED----RKTIVITELPYGVWTSDLIEKI 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 671355845  240 ADLVRDKKIEGITDLRDESDRtGMRIVIEIRRDANANVILNNLYKQTALQTS 291
Cdd:pfam00521 240 EELVKNGKIKGISDIRDESDR-GVRIVIELKRGADPEVVLNDLYKKTKLQTS 290
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 1-291 1.40e-165

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 466.66  E-value: 1.40e-165
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845     1 RDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV-DGDS 79
Cdd:smart00434  28 RDGLKPVQRRILYAMFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIVRMAQDFSNNYPLLDGQGNFGSRlDGDD 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845    80 AAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLA 159
Cdd:smart00434 108 AAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVNGSSGIAVGMATNIPPHNLREVIDAVRR 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845   160 VSENPDVTIPELMEVIPGPDFPTAGQILGRSgirkayesgrgSITIRAKAEIEqtssGKERIIVTELPYQVNKAKLIEKI 239
Cdd:smart00434 188 LIDNPDASIDELMMIPWGPDFPTGGEIVGPG-----------KYVVRGKIEIE----DDNTIVITELPYQVNTADLIEKI 252

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 671355845   240 ADLVRDKKIEGITDLRDES-DRTGMRIVIEIRRDANANVILNNLYKQTALQTS 291
Cdd:smart00434 253 AELVKDKKIEGIIDVRDEShDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTT 305
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 1-291 0e+00

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 678.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845   1 RDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSA 80
Cdd:PRK05560  35 RDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPA 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845  81 AAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAV 160
Cdd:PRK05560 115 AAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACLAL 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845 161 SENPDVTIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTsSGKERIIVTELPYQVNKAKLIEKIA 240
Cdd:PRK05560 195 IDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKAEIEEI-KGREAIIVTEIPYQVNKARLIEKIA 273

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 671355845 241 DLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTS 291
Cdd:PRK05560 274 ELVKEKKIEGISDLRDESDRDGMRIVIELKRDAVPEVVLNNLYKHTQLQTS 324
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-291 0e+00

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 665.20  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845   1 RDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSA 80
Cdd:COG0188   40 RDGLKPVHRRILYAMHELGLTPDKPYKKSARVVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPA 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845  81 AAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAV 160
Cdd:COG0188  120 AAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACIAL 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845 161 SENPDVTIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEKIA 240
Cdd:COG0188  200 IDNPDATIEELMEYIPGPDFPTGGIIVGREGIREAYETGRGSIRVRAKAEIEELKRGREQIVVTEIPYQVNKARLIEKIA 279

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 671355845 241 DLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTS 291
Cdd:COG0188  280 ELVKEKKIEGISDVRDESDRDGMRIVIELKRDANPEVVLNQLYKHTQLQTS 330
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 1-291 0e+00

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 593.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845    1 RDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSA 80
Cdd:TIGR01063  31 RDGLKPVHRRILYAMYELGLTPDKPYKKSARIVGDVMGKYHPHGDSAIYDTLVRMAQDFSLRYPLVDGQGNFGSIDGDPP 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845   81 AAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAV 160
Cdd:TIGR01063 111 AAMRYTEARLTKIAEELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLLVNGSSGIAVGMATNIPPHNLGEIIDALLAY 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845  161 SENPDVTIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEKIA 240
Cdd:TIGR01063 191 IDNPDISIQELLEVIKGPDFPTGGIILGRSGIRSAYETGRGSIVIRARAEIEEDSKGREAIIVTEIPYQVNKARLIEKIA 270

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 671355845  241 DLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTS 291
Cdd:TIGR01063 271 ELVREKKIEGISDIRDESDREGIRIVIELKRDAVAEVVLNNLYKQTQLQVS 321
PRK05561 PRK05561
DNA topoisomerase 4 subunit A;
1-291 0e+00

DNA topoisomerase 4 subunit A;


Pssm-ID: 235503 [Multi-domain]  Cd Length: 742  Bit Score: 554.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845   1 RDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSA 80
Cdd:PRK05561  40 RDGLKPVQRRILYAMSELGLTPDAKFKKSARVVGDVLGKYHPHGDSSIYDAMVRMAQDFSYRYPLVDGQGNFGSIDGDPA 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845  81 AAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAV 160
Cdd:PRK05561 120 AAMRYTEARLSPIAELLLEEIDEGTVDFVPNFDGTLKEPTVLPARFPNLLLNGATGIAVGMATDIPPHNLREVIDAAIHL 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845 161 SENPDVTIPELMEVIPGPDFPTAGQIL-GRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEKI 239
Cdd:PRK05561 200 IDNPDATLEELMEFVPGPDFPTGGEIItGRDGIRKAYETGRGSIRVRARWEIEDLAGGRWQIVITELPYQVSKAKLIEQI 279

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 671355845 240 ADLVRDKKIEGITDLRDESDRTG-MRIVIEIR-RDANANVILNNLYKQTALQTS 291
Cdd:PRK05561 280 AELMNAKKLPGIADVRDESDRENpVRIVIEPKsNRVDPEALMNHLFATTDLESS 333
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 1-291 0e+00

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 524.44  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845   1 RDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSA 80
Cdd:cd00187    9 RDGLKPVQRRILYAMFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNFGSRDGDDA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845  81 AAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAV 160
Cdd:cd00187   89 AAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLREVIDALRAL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845 161 SENPDVTIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEqTSSGKERIIVTELPYQVNKAKLIEKIA 240
Cdd:cd00187  169 IDNPEASIDELMEIIKGPDFPTGGIIEGRAGIREAYETGRGRYIIRGKYEIE-DDEGRNTIEITELPYQVNKAKLKEKIA 247

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 671355845 241 DLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTS 291
Cdd:cd00187  248 ELVKDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTT 298
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
1-291 5.14e-167

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 470.11  E-value: 5.14e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845    1 RDGLKPVHRRILYAMNDLgMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV-DGDS 79
Cdd:pfam00521   7 RDGLKPVQRRILYAMFEL-LNLDKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGSRiDGDK 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845   80 AAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLA 159
Cdd:pfam00521  86 DAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREIIDALIA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845  160 VSENPDVTIpeLMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQtssgKERIIVTELPYQVNKAKLIEKI 239
Cdd:pfam00521 166 LLDGPEATL--LMKYIMGPDFPTGGGIIGKGGIKEAYKTGRGKITVRAKVEIED----RKTIVITELPYGVWTSDLIEKI 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 671355845  240 ADLVRDKKIEGITDLRDESDRtGMRIVIEIRRDANANVILNNLYKQTALQTS 291
Cdd:pfam00521 240 EELVKNGKIKGISDIRDESDR-GVRIVIELKRGADPEVVLNDLYKKTKLQTS 290
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 1-291 1.40e-165

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 466.66  E-value: 1.40e-165
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845     1 RDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSV-DGDS 79
Cdd:smart00434  28 RDGLKPVQRRILYAMFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIVRMAQDFSNNYPLLDGQGNFGSRlDGDD 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845    80 AAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLA 159
Cdd:smart00434 108 AAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVNGSSGIAVGMATNIPPHNLREVIDAVRR 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845   160 VSENPDVTIPELMEVIPGPDFPTAGQILGRSgirkayesgrgSITIRAKAEIEqtssGKERIIVTELPYQVNKAKLIEKI 239
Cdd:smart00434 188 LIDNPDASIDELMMIPWGPDFPTGGEIVGPG-----------KYVVRGKIEIE----DDNTIVITELPYQVNTADLIEKI 252

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 671355845   240 ADLVRDKKIEGITDLRDES-DRTGMRIVIEIRRDANANVILNNLYKQTALQTS 291
Cdd:smart00434 253 AELVKDKKIEGIIDVRDEShDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTT 305
PRK13979 PRK13979
DNA topoisomerase IV subunit A; Provisional
 1-289 1.26e-144

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 237576 [Multi-domain]  Cd Length: 957  Bit Score: 429.91  E-value: 1.26e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845   1 RDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSA 80
Cdd:PRK13979  43 RDGLKPVHRRILYGAYMLKAFPDKPYYKSARIVGDILGKYHPHGDSSVYDAMVILAQDFTTRMPLIDGHGNWGSIDGDSA 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845  81 AAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAV 160
Cdd:PRK13979 123 AAMRYTEARLTPIAMEMLRDIDKDVVNMVDNYSDSEKEPEVLPARYPNLLVNGAFGIAVGLATNIPPHNLKEVIDGTLAY 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845 161 SENPDVTIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEKIA 240
Cdd:PRK13979 203 IDNNEITTKELMNYIKGPDLPTGGILIGKKSLLSAYETGEGKVTLRAKTKIEKLENGRLGIVITEFPYRRNKAKLLQTIS 282

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 671355845 241 DLVRDKK----IEGITDLRDESDRTGMRIVIEIRRDAN---ANVILNNLYKQTALQ 289
Cdd:PRK13979 283 EMTADKKhskaLENISDIRDESDRNGIRAVIEFKKSADedvAEKVLKYLYKKTDLQ 338
parC_Gpos TIGR01061
DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II ...
 1-291 2.61e-140

DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273422 [Multi-domain]  Cd Length: 738  Bit Score: 412.66  E-value: 2.61e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845    1 RDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSA 80
Cdd:TIGR01061  31 RDGLKPVQRRILYAMFQDGNTFDKPYKKSARTVGEIMGKYHPHGDSSIYDAMVRMSQDWKNNWTLVEMHGNNGSIDGDNA 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845   81 AAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAV 160
Cdd:TIGR01061 111 AAMRYTEARLSLIASELLKDIDKKTVSFIPNFDDSEKEPTVLPALFPNLLINGATGIAAGYATNIPPHNLNEVIDALIYR 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845  161 SENPDVTIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEKIA 240
Cdd:TIGR01061 191 IDHPNCSVDKLMEIVKGPDFPTGGIIQGEDGISKAYETGKGKFIIRAKIEIEVNKNGLNQIVITEIPYETNKANIVKKIE 270

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 671355845  241 DLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTS 291
Cdd:TIGR01061 271 EIIFDNKVAGIEEVRDESDRNGIRIIIELKKDANAEKILNFLFKHTDLQIN 321
parC_Gneg TIGR01062
DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II ...
 1-291 2.50e-125

DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 130134 [Multi-domain]  Cd Length: 735  Bit Score: 374.25  E-value: 2.50e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845    1 RDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDG-DS 79
Cdd:TIGR01062  31 GDGLKPVQRRIVYAMSELGLNANAKYKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDpKS 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845   80 AAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLA 159
Cdd:TIGR01062 111 FAAMRYTESRLSKISELLLEELGQGTVDFRPNFDGTLLEPVILPARLPNILLNGTTGIAVGMATDIPPHNLHELADAALY 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845  160 VSENPDVTIPELMEVIPGPDFPTAGQILG-RSGIRKAYESGRGSITIRAKAEIEQTSsgkerIIVTELPYQVNKAKLIEK 238
Cdd:TIGR01062 191 LIDNPKAGLDDILNIVQGPDFPTEAEIIDkAEEIRKIYETGRGSFRMRARWKKEDGQ-----IVISALPHQISKSKVIEQ 265

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 671355845  239 IADLVRDKKIEGITDLRDESDRTG-MRIVIEIR-RDANANVILNNLYKQTALQTS 291
Cdd:TIGR01062 266 IAIQMKDKKLPMISDIRDESDHENpIRVVIVPRsNRVDPDIVMEHLFATTDLEKS 320
PRK09631 PRK09631
DNA topoisomerase IV subunit A; Provisional
 2-291 6.75e-56

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 236598 [Multi-domain]  Cd Length: 635  Bit Score: 190.30  E-value: 6.75e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845   2 DGLKPVHRRILYAMNDLgmtSDKPYKKSARIVGEVIgKYHPHGDSAVYESMVRMA-QDFnyrymLVDGHGNFGSV-DGDS 79
Cdd:PRK09631  30 DGLKPVQRRILHSLFEM---HDGKFHKVANVVGNTM-KYHPHGDASIYEALVNLAnKDL-----FIDKQGNFGNLfTGDP 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845  80 AAAMRYTEARMSKISMEIL--RDITkdtiDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGV 157
Cdd:PRK09631 101 ASAARYIECRLTPLAKEVLynKEIT----EYEPSYDGRNNEPLCLPAKIPVILIQGAEGIAVGMATKILPHNFNEILQAV 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845 158 LAVSENPDVTIPelmevipgPDFPTAGqILGRSGirkaYESGRGSITIRAKAEIeqtsSGKERIIVTELPYQVNKAKLIE 237
Cdd:PRK09631 177 KSELLGESFALY--------PDFPTGG-IVDVSE----YADGNGKVLVRAKIET----KDEKTIVIREIPFGTTTESLIA 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 671355845 238 KIADLVRDKKIEgITDLrdeSDRTGMRIVIEIR--RDANANVILNNLYKQTALQTS 291
Cdd:PRK09631 240 SIEKAARKGKIK-ISSI---NDYTAENVEIEIKlpRGVYASEVIEALYAYTDCEVS 291
PRK12758 PRK12758
DNA gyrase/topoisomerase IV subunit A;
2-239 2.28e-52

DNA gyrase/topoisomerase IV subunit A;


Pssm-ID: 237192 [Multi-domain]  Cd Length: 869  Bit Score: 183.28  E-value: 2.28e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845   2 DGLKPVHRRILYAMNDLgmtSDKPYKKSARIVGEVIgKYHPHGDSAVYESMVRMAQdfnyRYMLVDGHGNFGSV-DGDSA 80
Cdd:PRK12758  49 DGLKPVQRRILHSMKEM---DDGRYNKVANVVGHTM-QYHPHGDASIGDALVQLGQ----KDLLIDTQGNWGNIlTGDGA 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845  81 AAMRYTEARMSKISMEILrdITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAV 160
Cdd:PRK12758 121 AAPRYIEARLSKFALEVV--FNPKTTEWQLSYDGRKKEPVTLPVKFPLLLAQGAEGIAVGLSTKILPHNFNELIDASIAY 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845 161 SENPDVTIPelmevipgPDFPTAGqILGRSgirkAYESGR--GSITIRAKaeIEQTSsgKERIIVTELPYQVNKAKLIEK 238
Cdd:PRK12758 199 LKGKEFKLY--------PDFPTGG-IIDVS----NYNDGErgGRVRVRAK--IEKLD--KKTLVITEIPYGTTTSSLIDS 261


                 .
gi 671355845 239 I 239
Cdd:PRK12758 262 I 262
PRK09630 PRK09630
DNA topoisomerase IV subunit A; Provisional
 2-289 5.36e-43

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 170022  Cd Length: 479  Bit Score: 153.13  E-value: 5.36e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845   2 DGLKPVHRRILYAmndLGMTSDKPYKKSARIVGEVIGkYHPHGDSAVYESMVRMAqdfNYRYmLVDGHGNFGS-VDGDSA 80
Cdd:PRK09630  30 DGLKPVQRRLLWT---LFRMDDGKMHKVANIAGRTMA-LHPHGDAPIVEALVVLA---NKGY-LIDTQGNFGNpLTGDPH 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845  81 AAMRYTEARMSKISMEILrdITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAV 160
Cdd:PRK09630 102 AAARYIEARLSPLAKEVL--FNTDLMTFHDSYDGREKEPDILPAKLPLLLLHGVDGIAVGMTTKIFPHNFCELLEAQIAI 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845 161 SENPDVTIPelmevipgPDFPTAGQILGRSgirkaYESGRGSITIRAKAEIEQTSSgkerIIVTELPYQVNKAKLIEKIA 240
Cdd:PRK09630 180 LNDQPFTLL--------PDFPSGGTMDASE-----YQDGLGSITLRASIDIINDKT----LLIKEICPSTTTETLIRSIE 242

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 671355845 241 DLVRDK--KIEGITDLRDESDrtgmRIVIEIRRDANANVILNNLYKQTALQ 289
Cdd:PRK09630 243 NAAKRGiiKIDSIQDFSTDLP----HIEIKLPKGIYAKDLLRPLFTHTECQ 289
52 PHA02592
DNA topisomerase II medium subunit; Provisional
 2-277 1.14e-35

DNA topisomerase II medium subunit; Provisional


Pssm-ID: 222896 [Multi-domain]  Cd Length: 439  Bit Score: 132.87  E-value: 1.14e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845   2 DGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEV--IGkYHpHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDS 79
Cdd:PHA02592  34 DGLKPVQRFVIHRALEYAKGNKEKFDKVAAIAGGVadLG-YH-HGETSAQDAGALMANTWNNNIPLLDGQGNFGSRLVQK 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845  80 AAAMRYTEARMSkismEILRDITKDtIDYQDNYDGSERepvvMPSRF-----PNLLVNGAAGIAVGMATNIPPHQLGEII 154
Cdd:PHA02592 112 AAAARYIFARVH----DNFRKIYKD-EDLAPVHEDPEH----IPPAFylpiiPMVLLNGVSGIATGYATNILPHSPKSVI 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845 155 DGVLAVSENPDVTIPElmevipgPDFPtagqilGRSGirKAYESGRGSITIRAKAEIeqtsSGKERIIVTELPYQVNKAK 234
Cdd:PHA02592 183 KAVLAALNGKDITEPK-------VQFP------EFKG--EVVEIEPGSYEIRGTYEL----NGKTKLHITEIPVKYDRET 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 671355845 235 LIEKIADLVRDKKIEGITDLRDEsdrtGMRIVIEIRRDANANV 277
Cdd:PHA02592 244 YVAVLDPLEEKGKIVSYDDCTED----GFRFKVTLKREENEEA 282
PLN03128 PLN03128
DNA topoisomerase 2; Provisional
 2-291 3.34e-21

DNA topoisomerase 2; Provisional


Pssm-ID: 215593 [Multi-domain]  Cd Length: 1135  Bit Score: 93.62  E-value: 3.34e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845    2 DGLKPVHRRILYAMNDLGMTSDKpykKSARIVGEVI--GKYHpHGDSAVYESMVRMAQDF---NYRYMLVDgHGNFGS-- 74
Cdd:PLN03128  680 DGLKPSQRKVLFACFKRNLKSEI---KVAQLSGYVAehSAYH-HGEASLASTIIGMAQDFvgsNNINLLTP-SGQFGTrl 754

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845   75 VDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNyDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHqlgeii 154
Cdd:PLN03128  755 QGGKDAASARYIFTRLSPITRALFPKDDDVLLNYLNE-DGQSIEPEWYCPIIPMVLVNGSEGIGTGWSTFIPNY------ 827

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845  155 dgvlavseNPDVTIPELMEVIPGPDF-PTAGQILGRSG-IRKAYESGRGSITIRAKAEIEQTSSgkerIIVTELPYQV-- 230
Cdd:PLN03128  828 --------NPRDIIANIRRLLRGEELePMHPWYRGFKGtITEVSTSRSGSYTVTGIIEQIGDTT----IRITELPVRKwt 895

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 671355845  231 -NKAKLIEKIADLVRDKKIEgITDLRDESDRTGMRIVIEIRRDANANVILNNLYK----QTALQTS 291
Cdd:PLN03128  896 qDYKEFLEALLTGTKKKEPE-IKDFKENHTDTTVHFTVTLSEEKMARALAEGLEKkfklSTTISTS 960
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 2-291 9.16e-18

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 83.56  E-value: 9.16e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845    2 DGLKPVHRRILYAM------NDLgmtsdkpykKSARIVGEVIGK--YHpHGDSAVYESMVRMAQDF----NYRYMLVDGH 69
Cdd:PTZ00108  687 DGLKPGQRKILFACfkrnlkNEI---------KVAQLSGYVSEHsaYH-HGEQSLQQTIVGMAQNFvgsnNINLLYPCGQ 756

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845   70 gnFGS--VDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNyDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPP 147
Cdd:PTZ00108  757 --FGSrlQGGKDHAAARYIFTKLSKITRYIFPEEDDPILDYLED-DGQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPN 833

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845  148 HQLGEIIDGVLAVSENpdvtiPELMEVIPgpdfptagqilgrsgirkAYESGRGSITIRAKAEIEqtSSGK------ERI 221
Cdd:PTZ00108  834 YNPLDIIDNLRRRLNG-----EEVRPLVP------------------WYRGFKGTIERNPKGKFI--SKGIyekvpdGTV 888

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 671355845  222 IVTELPYQV---NKAKLIEKIAdlvrDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTS 291
Cdd:PTZ00108  889 EITELPIGKwteDYKEFLESET----LKEKDVIVDYRDYSTANTVHFTVKLNDGVLEQWEEEGIEKVFKLKST 957
PLN03237 PLN03237
DNA topoisomerase 2; Provisional
 2-267 3.00e-13

DNA topoisomerase 2; Provisional


Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 69.89  E-value: 3.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845    2 DGLKPVHRRILYAMNDLGMTSDKpykKSARIVGEV--IGKYHpHGDSAVYESMVRMAQDF---NYRYMLVDGhGNFG--S 74
Cdd:PLN03237  705 DGLKPGQRKILFCSFKRNFVKEA---KVAQLSGYVseHSAYH-HGEQSLASTIIGMAQDFvgsNNINLLLPN-GQFGtrL 779

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845   75 VDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNyDGSEREPV-VMPSrFPNLLVNGAAGIAVGMATNIPPHQLGEI 153
Cdd:PLN03237  780 QGGKDHASARYIFTRLSPITRFLFPKDDDILLDYLNE-DGQSIEPTwYMPI-IPTVLVNGAEGIGTGWSTFIPNYNPRDI 857

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671355845  154 IDGVLAVSENpdvtipELMEvipgPDFPTagqilgrsgirkaYESGRGSI--TIRAKAEIEQTSSGK------ERIIVTE 225
Cdd:PLN03237  858 VANIRRLLNG------ESME----PMHPW-------------YRGFKGTIekTASKEGGCTYTITGLyeevdeTTLRITE 914

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 671355845  226 LP---YQVNKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRIVI 267
Cdd:PLN03237  915 LPirrWTDDYKEFLESLKTDNNKNKDPFIKDVKAYNDDTTVHFEV 959
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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