NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|688446279|gb|AIQ84249|]
View 

cystic fibrosis transmembrane conductance regulator, partial [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CFTR_protein super family cl36858
cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis ...
 1-26 8.69e-14

cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis fibrosis transmembrane conductor regulator (CFTR) in eukaryotes. The principal role of this protein is chloride ion conductance. The protein is predicted to consist of 12 transmembrane domains. Mutations or lesions in the genetic loci have been linked to the aetiology of asthma, bronchiectasis, chronic obstructive pulmonary disease etc. Disease-causing mutations have been studied by 36Cl efflux assays in vitro cell cultures and electrophysiology, all of which point to the impairment of chloride channel stability and not the biosynthetic processing per se. [Transport and binding proteins, Anions]


The actual alignment was detected with superfamily member TIGR01271:

Pssm-ID: 273530 [Multi-domain]  Cd Length: 1490  Bit Score: 61.46  E-value: 8.69e-14
                           10        20
                   ....*....|....*....|....*.
gi 688446279     1 YKDADLYLLDSPFGYLDVLTEKEIFE 26
Cdd:TIGR01271  564 YKDADLYLLDSPFTHLDVVTEKEIFE 589
 
Name Accession Description Interval E-value
CFTR_protein TIGR01271
cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis ...
 1-26 8.69e-14

cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis fibrosis transmembrane conductor regulator (CFTR) in eukaryotes. The principal role of this protein is chloride ion conductance. The protein is predicted to consist of 12 transmembrane domains. Mutations or lesions in the genetic loci have been linked to the aetiology of asthma, bronchiectasis, chronic obstructive pulmonary disease etc. Disease-causing mutations have been studied by 36Cl efflux assays in vitro cell cultures and electrophysiology, all of which point to the impairment of chloride channel stability and not the biosynthetic processing per se. [Transport and binding proteins, Anions]


Pssm-ID: 273530 [Multi-domain]  Cd Length: 1490  Bit Score: 61.46  E-value: 8.69e-14
                           10        20
                   ....*....|....*....|....*.
gi 688446279     1 YKDADLYLLDSPFGYLDVLTEKEIFE 26
Cdd:TIGR01271  564 YKDADLYLLDSPFTHLDVVTEKEIFE 589
ABCC_CFTR1 cd03291
ATP-binding cassette domain of the cystic fibrosis transmembrane regulator, subfamily C; The ...
 1-26 5.67e-13

ATP-binding cassette domain of the cystic fibrosis transmembrane regulator, subfamily C; The CFTR subfamily domain 1. The cystic fibrosis transmembrane regulator (CFTR), the product of the gene mutated in patients with cystic fibrosis, has adapted the ABC transporter structural motif to form a tightly regulated anion channel at the apical surface of many epithelia. Use of the term assembly of a functional ion channel implies the coming together of subunits, or at least smaller not-yet functional components of the active whole. In fact, on the basis of current knowledge only the CFTR polypeptide itself is required to form an ATP- and protein kinase A-dependent low-conductance chloride channel of the type present in the apical membrane of many epithelial cells. CFTR displays the typical organization (IM-ABC)2 and carries a characteristic hydrophilic R-domain that separates IM1-ABC1 from IM2-ABC2.


Pssm-ID: 213258 [Multi-domain]  Cd Length: 282  Bit Score: 58.71  E-value: 5.67e-13
                         10        20
                 ....*....|....*....|....*.
gi 688446279   1 YKDADLYLLDSPFGYLDVLTEKEIFE 26
Cdd:cd03291  175 YKDADLYLLDSPFGYLDVFTEKEIFE 200
PRK13409 PRK13409
ribosome biogenesis/translation initiation ATPase RLI;
2-18 2.49e-04

ribosome biogenesis/translation initiation ATPase RLI;


Pssm-ID: 184037 [Multi-domain]  Cd Length: 590  Bit Score: 34.40  E-value: 2.49e-04
                         10
                 ....*....|....*..
gi 688446279   2 KDADLYLLDSPFGYLDV 18
Cdd:PRK13409 470 RDADLYLLDEPSAHLDV 486
Rli1 COG1245
Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ...
 2-18 4.30e-04

Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440858 [Multi-domain]  Cd Length: 592  Bit Score: 33.99  E-value: 4.30e-04
                         10
                 ....*....|....*..
gi 688446279   2 KDADLYLLDSPFGYLDV 18
Cdd:COG1245  472 RDADLYLLDEPSAHLDV 488
 
Name Accession Description Interval E-value
CFTR_protein TIGR01271
cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis ...
 1-26 8.69e-14

cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis fibrosis transmembrane conductor regulator (CFTR) in eukaryotes. The principal role of this protein is chloride ion conductance. The protein is predicted to consist of 12 transmembrane domains. Mutations or lesions in the genetic loci have been linked to the aetiology of asthma, bronchiectasis, chronic obstructive pulmonary disease etc. Disease-causing mutations have been studied by 36Cl efflux assays in vitro cell cultures and electrophysiology, all of which point to the impairment of chloride channel stability and not the biosynthetic processing per se. [Transport and binding proteins, Anions]


Pssm-ID: 273530 [Multi-domain]  Cd Length: 1490  Bit Score: 61.46  E-value: 8.69e-14
                           10        20
                   ....*....|....*....|....*.
gi 688446279     1 YKDADLYLLDSPFGYLDVLTEKEIFE 26
Cdd:TIGR01271  564 YKDADLYLLDSPFTHLDVVTEKEIFE 589
ABCC_CFTR1 cd03291
ATP-binding cassette domain of the cystic fibrosis transmembrane regulator, subfamily C; The ...
 1-26 5.67e-13

ATP-binding cassette domain of the cystic fibrosis transmembrane regulator, subfamily C; The CFTR subfamily domain 1. The cystic fibrosis transmembrane regulator (CFTR), the product of the gene mutated in patients with cystic fibrosis, has adapted the ABC transporter structural motif to form a tightly regulated anion channel at the apical surface of many epithelia. Use of the term assembly of a functional ion channel implies the coming together of subunits, or at least smaller not-yet functional components of the active whole. In fact, on the basis of current knowledge only the CFTR polypeptide itself is required to form an ATP- and protein kinase A-dependent low-conductance chloride channel of the type present in the apical membrane of many epithelial cells. CFTR displays the typical organization (IM-ABC)2 and carries a characteristic hydrophilic R-domain that separates IM1-ABC1 from IM2-ABC2.


Pssm-ID: 213258 [Multi-domain]  Cd Length: 282  Bit Score: 58.71  E-value: 5.67e-13
                         10        20
                 ....*....|....*....|....*.
gi 688446279   1 YKDADLYLLDSPFGYLDVLTEKEIFE 26
Cdd:cd03291  175 YKDADLYLLDSPFGYLDVFTEKEIFE 200
ABCC_MRP_domain1 cd03250
ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This ...
 1-26 1.03e-06

ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This subfamily is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resisting lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate.


Pssm-ID: 213217 [Multi-domain]  Cd Length: 204  Bit Score: 41.30  E-value: 1.03e-06
                         10        20
                 ....*....|....*....|....*.
gi 688446279   1 YKDADLYLLDSPFGYLDVLTEKEIFE 26
Cdd:cd03250  143 YSDADIYLLDDPLSAVDAHVGRHIFE 168
PRK13409 PRK13409
ribosome biogenesis/translation initiation ATPase RLI;
2-18 2.49e-04

ribosome biogenesis/translation initiation ATPase RLI;


Pssm-ID: 184037 [Multi-domain]  Cd Length: 590  Bit Score: 34.40  E-value: 2.49e-04
                         10
                 ....*....|....*..
gi 688446279   2 KDADLYLLDSPFGYLDV 18
Cdd:PRK13409 470 RDADLYLLDEPSAHLDV 486
Rli1 COG1245
Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ...
 2-18 4.30e-04

Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440858 [Multi-domain]  Cd Length: 592  Bit Score: 33.99  E-value: 4.30e-04
                         10
                 ....*....|....*..
gi 688446279   2 KDADLYLLDSPFGYLDV 18
Cdd:COG1245  472 RDADLYLLDEPSAHLDV 488
ABC_RNaseL_inhibitor_domain2 cd03237
The ATP-binding cassette domain 2 of RNase L inhibitor; The ABC ATPase, RNase L inhibitor (RLI) ...
 2-18 6.69e-04

The ATP-binding cassette domain 2 of RNase L inhibitor; The ABC ATPase, RNase L inhibitor (RLI), is a key enzyme in ribosomal biogenesis, formation of translation preinitiation complexes, and assembly of HIV capsids. RLI's are not transport proteins and thus cluster with a group of soluble proteins that lack the transmembrane components commonly found in other members of the family. Structurally, RLI's have an N-terminal Fe-S domain and two nucleotide-binding domains which are arranged to form two composite active sites in their interface cleft. RLI is one of the most conserved enzymes between archaea and eukaryotes with a sequence identity of more than 48%. The high degree of evolutionary conservation suggests that RLI performs a central role in archaeal and eukaryotic physiology.


Pssm-ID: 213204 [Multi-domain]  Cd Length: 246  Bit Score: 33.54  E-value: 6.69e-04
                         10
                 ....*....|....*..
gi 688446279   2 KDADLYLLDSPFGYLDV 18
Cdd:cd03237  132 KDADIYLLDEPSAYLDV 148
ABC_Metallic_Cations cd03235
ATP-binding cassette domain of the metal-type transporters; This family includes transporters ...
 3-26 9.16e-04

ATP-binding cassette domain of the metal-type transporters; This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-siderophore uptake family suggesting that they share a common ancestor. The best characterized metal-type ABC transporters are the YfeABCD system of Y. pestis, the SitABCD system of Salmonella enterica serovar Typhimurium, and the SitABCD transporter of Shigella flexneri. Moreover other uncharacterized homologs of these metal-type transporters are mainly found in pathogens like Haemophilus or enteroinvasive E. coli isolates.


Pssm-ID: 213202 [Multi-domain]  Cd Length: 213  Bit Score: 32.89  E-value: 9.16e-04
                         10        20
                 ....*....|....*....|....
gi 688446279   3 DADLYLLDSPFGYLDVLTEKEIFE 26
Cdd:cd03235  150 DPDLLLLDEPFAGVDPKTQEDIYE 173
MRP_assoc_pro TIGR00957
multi drug resistance-associated protein (MRP); This model describes multi drug ...
 1-26 1.29e-03

multi drug resistance-associated protein (MRP); This model describes multi drug resistance-associated protein (MRP) in eukaryotes. The multidrug resistance-associated protein is an integral membrane protein that causes multidrug resistance when overexpressed in mammalian cells. It belongs to ABC transporter superfamily. The protein topology and function was experimentally demonstrated by epitope tagging and immunofluorescence. Insertion of tags in the critical regions associated with drug efflux, abrogated its function. The C-terminal domain seem to highly conserved. [Transport and binding proteins, Other]


Pssm-ID: 188098 [Multi-domain]  Cd Length: 1522  Bit Score: 32.61  E-value: 1.29e-03
                           10        20
                   ....*....|....*....|....*.
gi 688446279     1 YKDADLYLLDSPFGYLDVLTEKEIFE 26
Cdd:TIGR00957  776 YSNADIYLFDDPLSAVDAHVGKHIFE 801
Rli1 COG1245
Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ...
 2-18 6.76e-03

Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440858 [Multi-domain]  Cd Length: 592  Bit Score: 30.52  E-value: 6.76e-03
                         10
                 ....*....|....*..
gi 688446279   2 KDADLYLLDSPFGYLDV 18
Cdd:COG1245  229 RDADFYFFDEPSSYLDI 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH